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Conserved domains on  [gi|1868669336|ref|NP_001372140|]
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anaphase-promoting complex subunit 7 isoform e [Homo sapiens]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11459274)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 208-430 4.34e-16

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 78.23  E-value: 4.34e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 208 AYAFVHTGDNSRAISTICSLEKKSllRDNVDLLGSLADLYFRAGDNKNSVLKFEQAQMLDPYLIKGMDVYGYLLAREGRL 287
Cdd:COG2956    49 GNLYRRRGEYDRAIRIHQKLLERD--PDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDW 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 288 EDVENLGCRLFNISDQHAEPWVVSGCHSFYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIR 367
Cdd:COG2956   127 EKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALE 206

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 368 LAPCRL-------DCYEGREQkYEDGIALLRNALANQSDCVLHRILGDFLVAVNEYQEAMDQYSIALSLD 430
Cdd:COG2956   207 QDPDYLpalprlaELYEKLGD-PEEALELLRKALELDPSDDLLLALADLLERKEGLEAALALLERQLRRH 275
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 99-293 2.60e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 39.71  E-value: 2.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336  99 PSEIEVKYKMAECYTMLKQDKDAIAILD-GIPSRQRTPKINMMLANLYKKAGQERPSVTSYKEVLRQCPLALDAILGLls 177
Cdd:COG2956   107 PDDAEALRLLAEIYEQEGDWEKAIEVLErLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLL-- 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 178 lsvkgaevasmtmnviqtvpnldwlsvwikAYAFVHTGDNSRAISTICSLEKKSllRDNVDLLGSLADLYFRAGDNKNSV 257
Cdd:COG2956   185 ------------------------------AELYLEQGDYEEAIAALERALEQD--PDYLPALPRLAELYEKLGDPEEAL 232

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1868669336 258 LKFEQAQMLDPYLIKgMDVYGYLLAREGRLEDVENL 293
Cdd:COG2956   233 ELLRKALELDPSDDL-LLALADLLERKEGLEAALAL 267
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 208-430 4.34e-16

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 78.23  E-value: 4.34e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 208 AYAFVHTGDNSRAISTICSLEKKSllRDNVDLLGSLADLYFRAGDNKNSVLKFEQAQMLDPYLIKGMDVYGYLLAREGRL 287
Cdd:COG2956    49 GNLYRRRGEYDRAIRIHQKLLERD--PDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDW 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 288 EDVENLGCRLFNISDQHAEPWVVSGCHSFYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIR 367
Cdd:COG2956   127 EKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALE 206

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 368 LAPCRL-------DCYEGREQkYEDGIALLRNALANQSDCVLHRILGDFLVAVNEYQEAMDQYSIALSLD 430
Cdd:COG2956   207 QDPDYLpalprlaELYEKLGD-PEEALELLRKALELDPSDDLLLALADLLERKEGLEAALALLERQLRRH 275
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 145-433 4.20e-07

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 52.78  E-value: 4.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 145 YKKAGQERPSVTSYKEVLRQCPLALDA--ILGLLSL---SVKGAE-----VASMTMNVIQTVPNLdwlsvwikAYAFVHT 214
Cdd:TIGR02917  32 YLQKNKYKAAIIQLKNALQKDPNDAEArfLLGKIYLalgDYAAAEkelrkALSLGYPKNQVLPLL--------ARAYLLQ 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 215 GDNSRAISTicsLEKKSLLRDN--VDLLGSLADLYFRAGDNKNSVLKFEQAQMLDPYLIKGMDVYGYLLAREGRLEDVEN 292
Cdd:TIGR02917 104 GKFQQVLDE---LPGKTLLDDEgaAELLALRGLAYLGLGQLELAQKSYEQALAIDPRSLYAKLGLAQLALAENRFDEARA 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 293 LGCRLFNISDQHAEPWVVSGCHSFYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCR 372
Cdd:TIGR02917 181 LIDEVLTADPGNVDALLLKGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALATILIEAGEFEEAEKHADALLKKAPNS 260

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1868669336 373 LDCY------EGREQKYEDGIALLRNAL-ANQSDCVLHRILGDFLVAVNEYQEAMDQYSIALSLDPND 433
Cdd:TIGR02917 261 PLAHylkalvDFQKKNYEDARETLQDALkSAPEYLPALLLAGASEYQLGNLEQAYQYLNQILKYAPNS 328
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 339-370 8.79e-04

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 36.66  E-value: 8.79e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1868669336  339 VQALLLKGAALRNMGRVQEAIIHFREAIRLAP 370
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALELDP 32
TPR_2 pfam07719
Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats ...
 339-370 1.09e-03

Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by pfam00515.


Pssm-ID: 429619 [Multi-domain]  Cd Length: 33  Bit Score: 36.35  E-value: 1.09e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1868669336 339 VQALLLKGAALRNMGRVQEAIIHFREAIRLAP 370
Cdd:pfam07719   1 AEALYNLGLAYYKLGDYEEALEAYEKALELDP 32
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 320-399 2.22e-03

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 39.92  E-value: 2.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 320 RYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPcrLDCYE----------GRE--QKYEDGI 387
Cdd:cd24142    15 NFELALKFLQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELDP--DGGYEkylylgqlsgGEEalQYYEKGI 92

                          90
                  ....*....|..
gi 1868669336 388 ALLRNALANQSD 399
Cdd:cd24142    93 EILEEELQALQA 104
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 99-293 2.60e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 39.71  E-value: 2.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336  99 PSEIEVKYKMAECYTMLKQDKDAIAILD-GIPSRQRTPKINMMLANLYKKAGQERPSVTSYKEVLRQCPLALDAILGLls 177
Cdd:COG2956   107 PDDAEALRLLAEIYEQEGDWEKAIEVLErLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLL-- 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 178 lsvkgaevasmtmnviqtvpnldwlsvwikAYAFVHTGDNSRAISTICSLEKKSllRDNVDLLGSLADLYFRAGDNKNSV 257
Cdd:COG2956   185 ------------------------------AELYLEQGDYEEAIAALERALEQD--PDYLPALPRLAELYEKLGDPEEAL 232

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1868669336 258 LKFEQAQMLDPYLIKgMDVYGYLLAREGRLEDVENL 293
Cdd:COG2956   233 ELLRKALELDPSDDL-LLALADLLERKEGLEAALAL 267
PRK11788 PRK11788
tetratricopeptide repeat protein; Provisional
 318-456 3.17e-03

tetratricopeptide repeat protein; Provisional


Pssm-ID: 236983 [Multi-domain]  Cd Length: 389  Bit Score: 39.79  E-value: 3.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 318 SKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRL--------DCYEgREQKYEDGIAL 389
Cdd:PRK11788  193 RGDLDAARALLKKALAADPQCVRASILLGDLALAQGDYAAAIEALERVEEQDPEYLsevlpklmECYQ-ALGDEAEGLEF 271

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 390 LRNALANQSDCVLHRILGDFLVAVNEYQEAMDQYSIALSLDPndqkSLEGMQK---MEKEESPTDATQEE 456
Cdd:PRK11788  272 LRRALEEYPGADLLLALAQLLEEQEGPEAAQALLREQLRRHP----SLRGFHRlldYHLAEAEEGRAKES 337
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 208-430 4.34e-16

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 78.23  E-value: 4.34e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 208 AYAFVHTGDNSRAISTICSLEKKSllRDNVDLLGSLADLYFRAGDNKNSVLKFEQAQMLDPYLIKGMDVYGYLLAREGRL 287
Cdd:COG2956    49 GNLYRRRGEYDRAIRIHQKLLERD--PDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDW 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 288 EDVENLGCRLFNISDQHAEPWVVSGCHSFYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIR 367
Cdd:COG2956   127 EKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALE 206

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 368 LAPCRL-------DCYEGREQkYEDGIALLRNALANQSDCVLHRILGDFLVAVNEYQEAMDQYSIALSLD 430
Cdd:COG2956   207 QDPDYLpalprlaELYEKLGD-PEEALELLRKALELDPSDDLLLALADLLERKEGLEAALALLERQLRRH 275
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
319-440 3.42e-15

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 75.04  E-value: 3.42e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 319 KRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGR------EQKYEDGIALLRN 392
Cdd:COG0457    22 GRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLglalqaLGRYEEALEDYDK 101

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1868669336 393 ALA-NQSDCVLHRILGDFLVAVNEYQEAMDQYSIALSLDPNDQKSLEGM 440
Cdd:COG0457   102 ALElDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNL 150
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 278-435 1.81e-12

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 69.64  E-value: 1.81e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 278 GYLLAREGRLEDVENLGCRLFNISDQHAEPWVVSGCHSFYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQE 357
Cdd:COG3914    85 ALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEE 164

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1868669336 358 AIIHFREAIRLAPCRLDcyegreqkyedgiallrnalanqsdcvLHRILGDFLVAVNEYQEAMDQYSIALSLDPNDQK 435
Cdd:COG3914   165 AIAALRRALELDPDNAE---------------------------ALNNLGNALQDLGRLEEAIAAYRRALELDPDNAD 215
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 302-433 2.15e-12

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 64.44  E-value: 2.15e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 302 DQHAEPWVVSGCHSFYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEG--- 378
Cdd:COG4783     1 AACAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNlgl 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1868669336 379 ---REQKYEDGIALLRNALANQSDCV-LHRILGDFLVAVNEYQEAMDQYSIALSLDPND 433
Cdd:COG4783    81 allKAGDYDEALALLEKALKLDPEHPeAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
266-433 3.31e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 66.18  E-value: 3.31e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 266 LDPYLIKGMDVYGYLLAREGRLEDVENLGCRLFNISDQHAEPWVVSGCHSFYSKRYSRALYLGAKAIQLNSNSVQALLLK 345
Cdd:COG0457     3 LDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 346 GAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGR------EQKYEDGIALLRNALANQSDCV-LHRILGDFLVAVNEYQE 418
Cdd:COG0457    83 GLALQALGRYEEALEDYDKALELDPDDAEALYNLglalleLGRYDEAIEAYERALELDPDDAdALYNLGIALEKLGRYEE 162

                         170
                  ....*....|....*
gi 1868669336 419 AMDQYSIALSLDPND 433
Cdd:COG0457   163 ALELLEKLEAAALAA 177
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 201-454 4.76e-12

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 66.29  E-value: 4.76e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 201 WLSVWIKAYAFVHTGDNSRAISTICSLEKKSllRDNVDLLGSLADLYFRAGDNKNSVLKFEQAQMLDPYLIKGMDVYGYL 280
Cdd:COG2956     8 ALGWYFKGLNYLLNGQPDKAIDLLEEALELD--PETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQD 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 281 LAREGRLEDVENLGCRLFNISDQHAEPWVVSGCHSFYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAII 360
Cdd:COG2956    86 YLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIE 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 361 HFREAIRLAPCRL-------DCYEgREQKYEDGIALLRNALA-NQSDCVLHRILGDFLVAVNEYQEAMDQYSIALSLDPN 432
Cdd:COG2956   166 ALEKALKLDPDCArallllaELYL-EQGDYEEAIAALERALEqDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPS 244

                         250       260
                  ....*....|....*....|..
gi 1868669336 433 DQKSLEGMQKMEKEESPTDATQ 454
Cdd:COG2956   245 DDLLLALADLLERKEGLEAALA 266
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 233-376 2.41e-11

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 66.17  E-value: 2.41e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 233 LRDNVDLLGSLADLYFRAGDNKNSVLKFEQAQMLDPYLIKGMDVYGYLLAREGRLEDVENLGCRLFNISDQHAEPWVVSG 312
Cdd:COG3914    74 LLLLAALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLG 153

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1868669336 313 CHSFYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCY 376
Cdd:COG3914   154 EALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAH 217
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 320-433 2.52e-11

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 66.17  E-value: 2.52e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 320 RYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYE------GREQKYEDGIALLRNA 393
Cdd:COG3914    59 LLALAAGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRALALNPDNAEALFnlgnllLALGRLEEALAALRRA 138

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1868669336 394 LANQSDCV-LHRILGDFLVAVNEYQEAMDQYSIALSLDPND 433
Cdd:COG3914   139 LALNPDFAeAYLNLGEALRRLGRLEEAIAALRRALELDPDN 179
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
332-440 2.77e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 63.49  E-value: 2.77e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 332 IQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGR------EQKYEDGIALLRNALANQSDCVLHRI 405
Cdd:COG0457     1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLglaylrLGRYEEALADYEQALELDPDDAEALN 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1868669336 406 -LGDFLVAVNEYQEAMDQYSIALSLDPNDQKSLEGM 440
Cdd:COG0457    81 nLGLALQALGRYEEALEDYDKALELDPDDAEALYNL 116
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
207-395 7.83e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 59.25  E-value: 7.83e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 207 KAYAFVHTGDNSRAISticSLEK-KSLLRDNVDLLGSLADLYFRAGDNKNSVLKFEQAQMLDPYLIKGMDVYGYLLAREG 285
Cdd:COG0457    14 LGLAYRRLGRYEEAIE---DYEKaLELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALG 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 286 RLEDVENLGCRLFNISDQHAEPWVVSGCHSFYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREA 365
Cdd:COG0457    91 RYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKL 170

                         170       180       190
                  ....*....|....*....|....*....|
gi 1868669336 366 IRLAPCRLDCYEGREQKYEDGIALLRNALA 395
Cdd:COG0457   171 EAAALAALLAAALGEAALALAAAEVLLALL 200
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 330-433 1.07e-09

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 56.55  E-value: 1.07e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 330 KAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEG------REQKYEDGIALLRNALANQSDCV-L 402
Cdd:COG4235     8 QALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDlaeallAAGDTEEAEELLERALALDPDNPeA 87

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1868669336 403 HRILGDFLVAVNEYQEAMDQYSIALSLDPND 433
Cdd:COG4235    88 LYLLGLAAFQQGDYAEAIAAWQKLLALLPAD 118
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 243-370 3.19e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 52.50  E-value: 3.19e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 243 LADLYFRAGDNKNSVLKFEQAQMLDPYLIKGMDVYGYLLAREGRLEDVENLGCRLFNISDQHAEPWVVSGCHSFYSKRYS 322
Cdd:COG4783    10 LAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYD 89

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1868669336 323 RALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAP 370
Cdd:COG4783    90 EALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDP 137
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
319-433 4.13e-07

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 50.68  E-value: 4.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 319 KRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPcrldcyegreqkyEDGIALLRNALAnqs 398
Cdd:COG4785    87 GDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDP-------------DYAYAYLNRGIA--- 150

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1868669336 399 dcvlHRILGDflvavneYQEAMDQYSIALSLDPND 433
Cdd:COG4785   151 ----LYYLGR-------YELAIADLEKALELDPND 174
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 145-433 4.20e-07

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 52.78  E-value: 4.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 145 YKKAGQERPSVTSYKEVLRQCPLALDA--ILGLLSL---SVKGAE-----VASMTMNVIQTVPNLdwlsvwikAYAFVHT 214
Cdd:TIGR02917  32 YLQKNKYKAAIIQLKNALQKDPNDAEArfLLGKIYLalgDYAAAEkelrkALSLGYPKNQVLPLL--------ARAYLLQ 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 215 GDNSRAISTicsLEKKSLLRDN--VDLLGSLADLYFRAGDNKNSVLKFEQAQMLDPYLIKGMDVYGYLLAREGRLEDVEN 292
Cdd:TIGR02917 104 GKFQQVLDE---LPGKTLLDDEgaAELLALRGLAYLGLGQLELAQKSYEQALAIDPRSLYAKLGLAQLALAENRFDEARA 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 293 LGCRLFNISDQHAEPWVVSGCHSFYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCR 372
Cdd:TIGR02917 181 LIDEVLTADPGNVDALLLKGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALATILIEAGEFEEAEKHADALLKKAPNS 260

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1868669336 373 LDCY------EGREQKYEDGIALLRNAL-ANQSDCVLHRILGDFLVAVNEYQEAMDQYSIALSLDPND 433
Cdd:TIGR02917 261 PLAHylkalvDFQKKNYEDARETLQDALkSAPEYLPALLLAGASEYQLGNLEQAYQYLNQILKYAPNS 328
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 257-370 1.26e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 47.69  E-value: 1.26e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 257 VLKFEQAQMLDPYLIKGMDVYGYLLAREGRLEDVENLGCRLFNISDQHAEPWVVSGCHSFYSKRYSRALYLGAKAIQLNS 336
Cdd:COG4235     3 IARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDP 82

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1868669336 337 NSVQALLLKGAALRNMGRVQEAIIHFREAIRLAP 370
Cdd:COG4235    83 DNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLP 116
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
312-421 1.99e-06

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 48.76  E-value: 1.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 312 GCHSFYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCrlDCYEG-------REQKYE 384
Cdd:COG4785   114 GLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLGRYELAIADLEKALELDPN--DPERAlwlylaeRKLDPE 191

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1868669336 385 DGIALLRNALANQsdcvlHRILGDFLVAVNEYQEAMD 421
Cdd:COG4785   192 KALALLLEDWATA-----YLLQGDTEEARELFKLALA 223
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 236-434 6.41e-06

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 48.93  E-value: 6.41e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 236 NVDLLGSLADLYFRAGDNKNSVLKFEQAQMLDPYLIKGMDVYGYLLAREGRLEDVENLGCRLFNISDQHAEPWVVSGCHS 315
Cdd:TIGR02917 532 NLRAILALAGLYLRTGNEEEAVAWLEKAAELNPQEIEPALALAQYYLGKGQLKKALAILNEAADAAPDSPEAWLMLGRAQ 611

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 316 FYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAP------CRLDCYEGREQKYEDGIAL 389
Cdd:TIGR02917 612 LAAGDLNKAVSSFKKLLALQPDSALALLLLADAYAVMKNYAKAITSLKRALELKPdnteaqIGLAQLLLAAKRTESAKKI 691

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1868669336 390 LRN-ALANQSDCVLHRILGDFLVAVNEYQEAMDQYSIALSLDPNDQ 434
Cdd:TIGR02917 692 AKSlQKQHPKAALGFELEGDLYLRQKDYPAAIQAYRKALKRAPSSQ 737
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 262-431 1.19e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 45.34  E-value: 1.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 262 QAQMLDPYLIKGMDVYGYLLAREGRLEDVENLGCRLFNISDQHAEPWVVSGCHSFYSKRYSRALYLGAKAIQLNSNSVQA 341
Cdd:COG5010    11 PLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPEL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 342 LLLKGAALRNMGRVQEAIIHFREAIRLAPcrldcyegreqkyedgiallrnalanqSDCVLHRILGDFLVAVNEYQEAMD 421
Cdd:COG5010    91 YYNLALLYSRSGDKDEAKEYYEKALALSP---------------------------DNPNAYSNLAALLLSLGQDDEAKA 143

                         170
                  ....*....|
gi 1868669336 422 QYSIALSLDP 431
Cdd:COG5010   144 ALQRALGTSP 153
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
348-432 2.07e-05

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 43.24  E-value: 2.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 348 ALRNMGRVQEAIIHFREAIRLAPCRLDCYEG------REQKYEDGIALLRNALANQSDCVLHRILGDFLVAVNEYQEAMD 421
Cdd:COG3063     1 LYLKLGDLEEAEEYYEKALELDPDNADALNNlgllllEQGRYDEAIALEKALKLDPNNAEALLNLAELLLELGDYDEALA 80

                          90
                  ....*....|.
gi 1868669336 422 QYSIALSLDPN 432
Cdd:COG3063    81 YLERALELDPS 91
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
246-370 6.01e-05

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 41.69  E-value: 6.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 246 LYFRAGDNKNSVLKFEQAQMLDPYLIKGMDVYGYLLAREGRLEDVENLgcrlfnisdqhaepwvvsgchsfyskrysral 325
Cdd:COG3063     1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIAL-------------------------------- 48

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1868669336 326 ylgAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAP 370
Cdd:COG3063    49 ---EKALKLDPNNAEALLNLAELLLELGDYDEALAYLERALELDP 90
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 321-455 6.28e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 45.84  E-value: 6.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 321 YSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAP----CRLDCYEG--REQKYEDGIALLRNAL 394
Cdd:TIGR02917 379 FEKAAEYLAKATELDPENAAARTQLGISKLSQGDPSEAIADLETAAQLDPelgrADLLLILSylRSGQFDKALAAAKKLE 458

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1868669336 395 ANQSD-CVLHRILGDFLVAVNEYQEAMDQYSIALSLDPNDQKSLEGMQKM-EKEESPTDATQE 455
Cdd:TIGR02917 459 KKQPDnASLHNLLGAIYLGKGDLAKAREAFEKALSIEPDFFPAAANLARIdIQEGNPDDAIQR 521
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 207-470 1.35e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 44.69  E-value: 1.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 207 KAYAFVHTGDNSRAISticSLEKK-SLLRDNVDLLGSLADLYFRAGDNKNSVLKFEQAQMLDPYLIKGMDVYGYLLAREG 285
Cdd:TIGR02917 471 LGAIYLGKGDLAKARE---AFEKAlSIEPDFFPAAANLARIDIQEGNPDDAIQRFEKVLTIDPKNLRAILALAGLYLRTG 547

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 286 RLEDVENLGCRLFNISDQHAEPWVVSGCHSFYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREA 365
Cdd:TIGR02917 548 NEEEAVAWLEKAAELNPQEIEPALALAQYYLGKGQLKKALAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSFKKL 627

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 366 IRLAPcrldcyegreqkyEDGIALLRnalanqsdcvlhriLGDFLVAVNEYQEAMDQYSIALSLDPNDQKSLEGMQKMEK 445
Cdd:TIGR02917 628 LALQP-------------DSALALLL--------------LADAYAVMKNYAKAITSLKRALELKPDNTEAQIGLAQLLL 680

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1868669336 446 EESPTDAT-------QEEDVDDMEGSGEEGDL 470
Cdd:TIGR02917 681 AAKRTESAkkiakslQKQHPKAALGFELEGDL 712
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 99-370 2.09e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 43.92  E-value: 2.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336  99 PSEIEVKYKMAECYTMLKQDKDAIAILDGIPSRQR-TPKINMMLANLYKKAGQERPSVTSYKEVLRQCP---LALdAILG 174
Cdd:TIGR02917 564 PQEIEPALALAQYYLGKGQLKKALAILNEAADAAPdSPEAWLMLGRAQLAAGDLNKAVSSFKKLLALQPdsaLAL-LLLA 642

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 175 LLSLSVKG-AEVASMTMNVIQTVPNLdWLSVWIKAYAFVHTGDNSRAISTICSLEKKSLLRDNVDLLgsLADLYFRAGDN 253
Cdd:TIGR02917 643 DAYAVMKNyAKAITSLKRALELKPDN-TEAQIGLAQLLLAAKRTESAKKIAKSLQKQHPKAALGFEL--EGDLYLRQKDY 719

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 254 KNSVLKFEQAQMLDPYLIKGMDVYGYLLAR------EGRLEDV-----------------------ENLGCRLFNISDQH 304
Cdd:TIGR02917 720 PAAIQAYRKALKRAPSSQNAIKLHRALLASgntaeaVKTLEAWlkthpndavlrtalaelylaqkdYDKAIKHYQTVVKK 799

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1868669336 305 AE--PWVVSGCHSFYSKRY-SRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAP 370
Cdd:TIGR02917 800 APdnAVVLNNLAWLYLELKdPRALEYAERALKLAPNIPAILDTLGWLLVEKGEADRALPLLRKAVNIAP 868
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 141-433 5.68e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 42.76  E-value: 5.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 141 LANLYKKAGQERPSVTSYKEVLRQCPLALDAILGLLS--LSVKGAEVASMTMNVIQ-TVPnlDWLSVW-IKAYAFVHTGD 216
Cdd:TIGR02917 539 LAGLYLRTGNEEEAVAWLEKAAELNPQEIEPALALAQyyLGKGQLKKALAILNEAAdAAP--DSPEAWlMLGRAQLAAGD 616

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 217 NSRAISTICSLEKksLLRDNVDLLGSLADLYFRAGDNKNSVLKFEQAQMLDPYLIKGMDVYGYLLAREGRLEDVENLGCR 296
Cdd:TIGR02917 617 LNKAVSSFKKLLA--LQPDSALALLLLADAYAVMKNYAKAITSLKRALELKPDNTEAQIGLAQLLLAAKRTESAKKIAKS 694

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 297 LFNISDQHAEPWVVSGCHSFYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNmGRVQEAiihfreairlapcrldcy 376
Cdd:TIGR02917 695 LQKQHPKAALGFELEGDLYLRQKDYPAAIQAYRKALKRAPSSQNAIKLHRALLAS-GNTAEA------------------ 755

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1868669336 377 egrEQKYEdgiALLRNalaNQSDCVLHRILGDFLVAVNEYQEAMDQYSIALSLDPND 433
Cdd:TIGR02917 756 ---VKTLE---AWLKT---HPNDAVLRTALAELYLAQKDYDKAIKHYQTVVKKAPDN 803
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 339-370 8.79e-04

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 36.66  E-value: 8.79e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1868669336  339 VQALLLKGAALRNMGRVQEAIIHFREAIRLAP 370
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALELDP 32
TPR_2 pfam07719
Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats ...
 339-370 1.09e-03

Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by pfam00515.


Pssm-ID: 429619 [Multi-domain]  Cd Length: 33  Bit Score: 36.35  E-value: 1.09e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1868669336 339 VQALLLKGAALRNMGRVQEAIIHFREAIRLAP 370
Cdd:pfam07719   1 AEALYNLGLAYYKLGDYEEALEAYEKALELDP 32
TPR_1 pfam00515
Tetratricopeptide repeat;
339-370 1.54e-03

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 36.24  E-value: 1.54e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1868669336 339 VQALLLKGAALRNMGRVQEAIIHFREAIRLAP 370
Cdd:pfam00515   1 AKALYNLGNAYFKLGKYDEALEYYEKALELNP 32
TPR_12 pfam13424
Tetratricopeptide repeat;
341-423 2.10e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 36.98  E-value: 2.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 341 ALLLKGAALRNMGRVQEAIIHFREAIRLApcrldcyegrEQKYEDGIALLRNALANQSDCvlHRILGDFLVAVNEYQEAM 420
Cdd:pfam13424   5 ALNNLAAVLRRLGRYDEALELLEKALEIA----------RRLLGPDHPLTATTLLNLGRL--YLELGRYEEALELLERAL 72


                  ...
gi 1868669336 421 DQY 423
Cdd:pfam13424  73 ALA 75
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 320-399 2.22e-03

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 39.92  E-value: 2.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 320 RYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPcrLDCYE----------GRE--QKYEDGI 387
Cdd:cd24142    15 NFELALKFLQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELDP--DGGYEkylylgqlsgGEEalQYYEKGI 92

                          90
                  ....*....|..
gi 1868669336 388 ALLRNALANQSD 399
Cdd:cd24142    93 EILEEELQALQA 104
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 99-293 2.60e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 39.71  E-value: 2.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336  99 PSEIEVKYKMAECYTMLKQDKDAIAILD-GIPSRQRTPKINMMLANLYKKAGQERPSVTSYKEVLRQCPLALDAILGLls 177
Cdd:COG2956   107 PDDAEALRLLAEIYEQEGDWEKAIEVLErLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLL-- 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 178 lsvkgaevasmtmnviqtvpnldwlsvwikAYAFVHTGDNSRAISTICSLEKKSllRDNVDLLGSLADLYFRAGDNKNSV 257
Cdd:COG2956   185 ------------------------------AELYLEQGDYEEAIAALERALEQD--PDYLPALPRLAELYEKLGDPEEAL 232

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1868669336 258 LKFEQAQMLDPYLIKgMDVYGYLLAREGRLEDVENL 293
Cdd:COG2956   233 ELLRKALELDPSDDL-LLALADLLERKEGLEAALAL 267
PRK11788 PRK11788
tetratricopeptide repeat protein; Provisional
 318-456 3.17e-03

tetratricopeptide repeat protein; Provisional


Pssm-ID: 236983 [Multi-domain]  Cd Length: 389  Bit Score: 39.79  E-value: 3.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 318 SKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRL--------DCYEgREQKYEDGIAL 389
Cdd:PRK11788  193 RGDLDAARALLKKALAADPQCVRASILLGDLALAQGDYAAAIEALERVEEQDPEYLsevlpklmECYQ-ALGDEAEGLEF 271

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336 390 LRNALANQSDCVLHRILGDFLVAVNEYQEAMDQYSIALSLDPndqkSLEGMQK---MEKEESPTDATQEE 456
Cdd:PRK11788  272 LRRALEEYPGADLLLALAQLLEEQEGPEAAQALLREQLRRHP----SLRGFHRlldYHLAEAEEGRAKES 337
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 232-289 5.80e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 36.91  E-value: 5.80e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1868669336 232 LLRDNVDLLGSLADLYFRAGDNKNSVLKFEQAQMLDPYLIKGMDVYGYLLAREGRLED 289
Cdd:COG4235    46 LDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQGDYAE 103
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 51-166 9.01e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 36.12  E-value: 9.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868669336  51 DSLFHDKEYRNAVSKYTMALQQKKalsktskvrpstgNSASTPQSQclpseievkYKMAECYTMLKQDKDAIAILDGI-- 128
Cdd:COG1729     1 KALLKAGDYDEAIAAFKAFLKRYP-------------NSPLAPDAL---------YWLGEAYYALGDYDEAAEAFEKLlk 58

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1868669336 129 --PSRQRTPKINMMLANLYKKAGQERPSVTSYKEVLRQCP 166
Cdd:COG1729    59 ryPDSPKAPDALLKLGLSYLELGDYDKARATLEELIKKYP 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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