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Conserved domains on  [gi|1867162189|ref|NP_001371951|]
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atos homolog protein A isoform 6 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Chromosome_seg pfam13889
Chromosome segregation during meiosis; The proteins come from eukaryotes, plants and animals, ...
 930-987 3.31e-21

Chromosome segregation during meiosis; The proteins come from eukaryotes, plants and animals, and are necessary for chromosome segregation during meiosis.


:

Pssm-ID: 464021  Cd Length: 55  Bit Score: 87.64  E-value: 3.31e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1867162189 930 LLRYLIHLRFQSSKSGKIYLHRDVRLLFSRKSMEVDSGaayELKSYTESPTNPQFSPR 987
Cdd:pfam13889   1 VLRYAIHLRFCCPKSGRFYLYKDIRVVFANRVPDGDEG---KLRVETETPSNPKYSPY 55
DUF4210 super family cl16474
Domain of unknown function (DUF4210); This short domain is found in fungi, plants and animals, ...
 790-847 2.07e-12

Domain of unknown function (DUF4210); This short domain is found in fungi, plants and animals, and the proteins appear to be necessary for chromosome segregation during meiosis.


The actual alignment was detected with superfamily member pfam13915:

Pssm-ID: 404751  Cd Length: 66  Bit Score: 63.07  E-value: 2.07e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1867162189 790 LLGNFEESVLNYRFD--PLGIVDgFTAEVGASGAF-------CPTHLTLPVEVSFYSVSDDNAPSPY 847
Cdd:pfam13915   1 LVGSYEESLLNGRMSttPSKPLD-FVAEIGVLGKGkcksslrCPPHLTLPFPAVFYSYGDIDKGSPY 66
SCP-1 super family cl30946
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 504-700 2.82e-05

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


The actual alignment was detected with superfamily member pfam05483:

Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 48.18  E-value: 2.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1867162189 504 EIIQSTYQETQNKSSSLSTSSILSQHKENNLDLTSRFKeqemsNGIDKQYSNCTTI----DKQICTNKYKEKIINE--NY 577
Cdd:pfam05483 363 ELLRTEQQRLEKNEDQLKIITMELQKKSSELEEMTKFK-----NNKEVELEELKKIlaedEKLLDEKKQFEKIAEElkGK 437

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1867162189 578 NPKFFGNLQSDDSKKNDSKIKVTVLEMSE--YLNKYESMSSNKDSKRPKtceqNTQLNSIENYLNKDNEGFKCKKSDQLK 655
Cdd:pfam05483 438 EQELIFLLQAREKEIHDLEIQLTAIKTSEehYLKEVEDLKTELEKEKLK----NIELTAHCDKLLLENKELTQEASDMTL 513

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1867162189 656 NEQDKQEDPTNEKSQNYSQRRSIKDCLSTCEQPKNT-EVLRTTLKH 700
Cdd:pfam05483 514 ELKKHQEDIINCKKQEERMLKQIENLEEKEMNLRDElESVREEFIQ 559
TroA-like super family cl00262
Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function ...
 382-432 4.83e-03

Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between two globular domains linked by a single helix. Many of these proteins also possess a low complexity region containing a metal-binding histidine-rich motif (repetitive HDH sequence). The TroA-like proteins differ in their fold and ligand-binding mechanism from the PBPI and PBPII proteins, but are structurally similar, however, to the beta-subunit of the nitrogenase molybdenum-iron protein MoFe. Most TroA-like proteins are encoded by ABC-type operons and appear to function as periplasmic components of ABC transporters in metal ion uptake.


The actual alignment was detected with superfamily member PRK11411:

Pssm-ID: 469696 [Multi-domain]  Cd Length: 303  Bit Score: 40.04  E-value: 4.83e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1867162189 382 ETNPLIGSLLQERQDVIARIAQHLEHIDPTASHIPR-----------QSFNMHDSSSVASKV 432
Cdd:PRK11411  140 QSAAIIGEVLGKKREMQARIEQHKERMAQFASQLPKgtrvafgtsreQQFNLHSPESYTGSV 201
 
Name Accession Description Interval E-value
Chromosome_seg pfam13889
Chromosome segregation during meiosis; The proteins come from eukaryotes, plants and animals, ...
 930-987 3.31e-21

Chromosome segregation during meiosis; The proteins come from eukaryotes, plants and animals, and are necessary for chromosome segregation during meiosis.


Pssm-ID: 464021  Cd Length: 55  Bit Score: 87.64  E-value: 3.31e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1867162189 930 LLRYLIHLRFQSSKSGKIYLHRDVRLLFSRKSMEVDSGaayELKSYTESPTNPQFSPR 987
Cdd:pfam13889   1 VLRYAIHLRFCCPKSGRFYLYKDIRVVFANRVPDGDEG---KLRVETETPSNPKYSPY 55
DUF4210 pfam13915
Domain of unknown function (DUF4210); This short domain is found in fungi, plants and animals, ...
 790-847 2.07e-12

Domain of unknown function (DUF4210); This short domain is found in fungi, plants and animals, and the proteins appear to be necessary for chromosome segregation during meiosis.


Pssm-ID: 404751  Cd Length: 66  Bit Score: 63.07  E-value: 2.07e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1867162189 790 LLGNFEESVLNYRFD--PLGIVDgFTAEVGASGAF-------CPTHLTLPVEVSFYSVSDDNAPSPY 847
Cdd:pfam13915   1 LVGSYEESLLNGRMSttPSKPLD-FVAEIGVLGKGkcksslrCPPHLTLPFPAVFYSYGDIDKGSPY 66
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 504-700 2.82e-05

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 48.18  E-value: 2.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1867162189 504 EIIQSTYQETQNKSSSLSTSSILSQHKENNLDLTSRFKeqemsNGIDKQYSNCTTI----DKQICTNKYKEKIINE--NY 577
Cdd:pfam05483 363 ELLRTEQQRLEKNEDQLKIITMELQKKSSELEEMTKFK-----NNKEVELEELKKIlaedEKLLDEKKQFEKIAEElkGK 437

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1867162189 578 NPKFFGNLQSDDSKKNDSKIKVTVLEMSE--YLNKYESMSSNKDSKRPKtceqNTQLNSIENYLNKDNEGFKCKKSDQLK 655
Cdd:pfam05483 438 EQELIFLLQAREKEIHDLEIQLTAIKTSEehYLKEVEDLKTELEKEKLK----NIELTAHCDKLLLENKELTQEASDMTL 513

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1867162189 656 NEQDKQEDPTNEKSQNYSQRRSIKDCLSTCEQPKNT-EVLRTTLKH 700
Cdd:pfam05483 514 ELKKHQEDIINCKKQEERMLKQIENLEEKEMNLRDElESVREEFIQ 559
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 434-670 1.21e-04

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 46.20  E-value: 1.21e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1867162189  434 RSSYEDKNLLKKNKDES-------------SVSISHTKCS-LLGDISDGKNLVPNKC--FTSFKNNSKEKCSLKHQTrnq 497
Cdd:TIGR01612  792 KNHYNDQINIDNIKDEDakqnydkskeyikTISIKEDEIFkIINEMKFMKDDFLNKVdkFINFENNCKEKIDSEHEQ--- 868

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1867162189  498 cqnnpseiiqstYQETQNKSSSLSTSSILSQHKENNLDLTSRFkeQEMSNGIDKQYSNCTTIDK-----QICTNKyKEKI 572
Cdd:TIGR01612  869 ------------FAELTNKIKAEISDDKLNDYEKKFNDSKSLI--NEINKSIEEEYQNINTLKKvdeyiKICENT-KESI 933

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1867162189  573 inENYNPKffGNLQSDDSKKNDSKIKVTVLEMSEYLNKYESMSSNKDSKRPKTCeQNTQLNSIE-------NYLNKDNEG 645
Cdd:TIGR01612  934 --EKFHNK--QNILKEILNKNIDTIKESNLIEKSYKDKFDNTLIDKINELDKAF-KDASLNDYEaknneliKYFNDLKAN 1008

                          250       260
                   ....*....|....*....|....*
gi 1867162189  646 FKCKKSDQLKNEQDKQEDPTNEKSQ 670
Cdd:TIGR01612 1009 LGKNKENMLYHQFDEKEKATNDIEQ 1033
fecB PRK11411
iron-dicitrate transporter substrate-binding subunit; Provisional
 382-432 4.83e-03

iron-dicitrate transporter substrate-binding subunit; Provisional


Pssm-ID: 183123 [Multi-domain]  Cd Length: 303  Bit Score: 40.04  E-value: 4.83e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1867162189 382 ETNPLIGSLLQERQDVIARIAQHLEHIDPTASHIPR-----------QSFNMHDSSSVASKV 432
Cdd:PRK11411  140 QSAAIIGEVLGKKREMQARIEQHKERMAQFASQLPKgtrvafgtsreQQFNLHSPESYTGSV 201
 
Name Accession Description Interval E-value
Chromosome_seg pfam13889
Chromosome segregation during meiosis; The proteins come from eukaryotes, plants and animals, ...
 930-987 3.31e-21

Chromosome segregation during meiosis; The proteins come from eukaryotes, plants and animals, and are necessary for chromosome segregation during meiosis.


Pssm-ID: 464021  Cd Length: 55  Bit Score: 87.64  E-value: 3.31e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1867162189 930 LLRYLIHLRFQSSKSGKIYLHRDVRLLFSRKSMEVDSGaayELKSYTESPTNPQFSPR 987
Cdd:pfam13889   1 VLRYAIHLRFCCPKSGRFYLYKDIRVVFANRVPDGDEG---KLRVETETPSNPKYSPY 55
DUF4210 pfam13915
Domain of unknown function (DUF4210); This short domain is found in fungi, plants and animals, ...
 790-847 2.07e-12

Domain of unknown function (DUF4210); This short domain is found in fungi, plants and animals, and the proteins appear to be necessary for chromosome segregation during meiosis.


Pssm-ID: 404751  Cd Length: 66  Bit Score: 63.07  E-value: 2.07e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1867162189 790 LLGNFEESVLNYRFD--PLGIVDgFTAEVGASGAF-------CPTHLTLPVEVSFYSVSDDNAPSPY 847
Cdd:pfam13915   1 LVGSYEESLLNGRMSttPSKPLD-FVAEIGVLGKGkcksslrCPPHLTLPFPAVFYSYGDIDKGSPY 66
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 504-700 2.82e-05

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 48.18  E-value: 2.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1867162189 504 EIIQSTYQETQNKSSSLSTSSILSQHKENNLDLTSRFKeqemsNGIDKQYSNCTTI----DKQICTNKYKEKIINE--NY 577
Cdd:pfam05483 363 ELLRTEQQRLEKNEDQLKIITMELQKKSSELEEMTKFK-----NNKEVELEELKKIlaedEKLLDEKKQFEKIAEElkGK 437

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1867162189 578 NPKFFGNLQSDDSKKNDSKIKVTVLEMSE--YLNKYESMSSNKDSKRPKtceqNTQLNSIENYLNKDNEGFKCKKSDQLK 655
Cdd:pfam05483 438 EQELIFLLQAREKEIHDLEIQLTAIKTSEehYLKEVEDLKTELEKEKLK----NIELTAHCDKLLLENKELTQEASDMTL 513

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1867162189 656 NEQDKQEDPTNEKSQNYSQRRSIKDCLSTCEQPKNT-EVLRTTLKH 700
Cdd:pfam05483 514 ELKKHQEDIINCKKQEERMLKQIENLEEKEMNLRDElESVREEFIQ 559
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 434-670 1.21e-04

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 46.20  E-value: 1.21e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1867162189  434 RSSYEDKNLLKKNKDES-------------SVSISHTKCS-LLGDISDGKNLVPNKC--FTSFKNNSKEKCSLKHQTrnq 497
Cdd:TIGR01612  792 KNHYNDQINIDNIKDEDakqnydkskeyikTISIKEDEIFkIINEMKFMKDDFLNKVdkFINFENNCKEKIDSEHEQ--- 868

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1867162189  498 cqnnpseiiqstYQETQNKSSSLSTSSILSQHKENNLDLTSRFkeQEMSNGIDKQYSNCTTIDK-----QICTNKyKEKI 572
Cdd:TIGR01612  869 ------------FAELTNKIKAEISDDKLNDYEKKFNDSKSLI--NEINKSIEEEYQNINTLKKvdeyiKICENT-KESI 933

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1867162189  573 inENYNPKffGNLQSDDSKKNDSKIKVTVLEMSEYLNKYESMSSNKDSKRPKTCeQNTQLNSIE-------NYLNKDNEG 645
Cdd:TIGR01612  934 --EKFHNK--QNILKEILNKNIDTIKESNLIEKSYKDKFDNTLIDKINELDKAF-KDASLNDYEaknneliKYFNDLKAN 1008

                          250       260
                   ....*....|....*....|....*
gi 1867162189  646 FKCKKSDQLKNEQDKQEDPTNEKSQ 670
Cdd:TIGR01612 1009 LGKNKENMLYHQFDEKEKATNDIEQ 1033
fecB PRK11411
iron-dicitrate transporter substrate-binding subunit; Provisional
 382-432 4.83e-03

iron-dicitrate transporter substrate-binding subunit; Provisional


Pssm-ID: 183123 [Multi-domain]  Cd Length: 303  Bit Score: 40.04  E-value: 4.83e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1867162189 382 ETNPLIGSLLQERQDVIARIAQHLEHIDPTASHIPR-----------QSFNMHDSSSVASKV 432
Cdd:PRK11411  140 QSAAIIGEVLGKKREMQARIEQHKERMAQFASQLPKgtrvafgtsreQQFNLHSPESYTGSV 201
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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