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Conserved domains on  [gi|1862755541|ref|NP_001371779|]
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microtubule-associated protein 4 isoform 61 [Homo sapiens]

Protein Classification

PHA03247 and Tubulin-binding domain-containing protein( domain architecture ID 10450448)

PHA03247 and Tubulin-binding domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
926-955 1.84e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 65.12  E-value: 1.84e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 1862755541  926 VQIVSKKVSYSHIQSKCGSKDNIKHVPGGG 955
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
957-986 2.91e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 64.35  E-value: 2.91e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 1862755541  957 VQIQNKKVDISKVSSKCGSKANIKHKPGGG 986
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
988-1018 5.60e-09

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 52.41  E-value: 5.60e-09
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1862755541  988 VKIESQKLNFKeKAQAKVGSLDNVGHLPAGG 1018
Cdd:pfam00418    1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
865-886 2.93e-08

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 50.10  E-value: 2.93e-08
                           10        20
                   ....*....|....*....|..
gi 1862755541  865 DLKNVRSKVGSTENIKHQPGGG 886
Cdd:pfam00418    9 DFSKVQSKCGSKDNIKHKPGGG 30
PHA03247 super family cl33720
large tegument protein UL36; Provisional
534-852 6.56e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.71  E-value: 6.56e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755541  534 DVPPLSETEATPVPIKDMEIAQTQKGISE-DSHLESLQDVGQSAAPTFMISPETVTGTGKKCSLPAEEDSVLeKLGERKP 612
Cdd:PHA03247  2590 DAPPQSARPRAPVDDRGDPRGPAPPSPLPpDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRV-SRPRRAR 2668
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755541  613 CNSQPSELSSETSGIARPEEGRPVVSGTGNDITTPPNKELPPSPEKKTKPAPTTIGGLNKKPMSLASglvPAAPPKRPAV 692
Cdd:PHA03247  2669 RLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPAL---PAAPAPPAVP 2745
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755541  693 ASArpsILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSgskSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIK 772
Cdd:PHA03247  2746 AGP---ATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRL---TRPAVASLSESRESLPSPWDPADPPAAVLAPAAALP 2819
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755541  773 TEGKPAEVKKMTAKSVPADLSRPKSTSTSSmkktTTLSGTAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTP 852
Cdd:PHA03247  2820 PAASPAGPLPPPTSAQPTAPPPPPGPPPPS----LPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRST 2895
 
Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
926-955 1.84e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 65.12  E-value: 1.84e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 1862755541  926 VQIVSKKVSYSHIQSKCGSKDNIKHVPGGG 955
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
957-986 2.91e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 64.35  E-value: 2.91e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 1862755541  957 VQIQNKKVDISKVSSKCGSKANIKHKPGGG 986
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
988-1018 5.60e-09

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 52.41  E-value: 5.60e-09
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1862755541  988 VKIESQKLNFKeKAQAKVGSLDNVGHLPAGG 1018
Cdd:pfam00418    1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
865-886 2.93e-08

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 50.10  E-value: 2.93e-08
                           10        20
                   ....*....|....*....|..
gi 1862755541  865 DLKNVRSKVGSTENIKHQPGGG 886
Cdd:pfam00418    9 DFSKVQSKCGSKDNIKHKPGGG 30
PHA03247 PHA03247
large tegument protein UL36; Provisional
534-852 6.56e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.71  E-value: 6.56e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755541  534 DVPPLSETEATPVPIKDMEIAQTQKGISE-DSHLESLQDVGQSAAPTFMISPETVTGTGKKCSLPAEEDSVLeKLGERKP 612
Cdd:PHA03247  2590 DAPPQSARPRAPVDDRGDPRGPAPPSPLPpDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRV-SRPRRAR 2668
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755541  613 CNSQPSELSSETSGIARPEEGRPVVSGTGNDITTPPNKELPPSPEKKTKPAPTTIGGLNKKPMSLASglvPAAPPKRPAV 692
Cdd:PHA03247  2669 RLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPAL---PAAPAPPAVP 2745
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755541  693 ASArpsILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSgskSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIK 772
Cdd:PHA03247  2746 AGP---ATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRL---TRPAVASLSESRESLPSPWDPADPPAAVLAPAAALP 2819
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755541  773 TEGKPAEVKKMTAKSVPADLSRPKSTSTSSmkktTTLSGTAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTP 852
Cdd:PHA03247  2820 PAASPAGPLPPPTSAQPTAPPPPPGPPPPS----LPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRST 2895
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
727-915 5.07e-03

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 40.71  E-value: 5.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755541  727 SAPASRSGSKSTQTVAKTttaaavasTGPSSRSPSTLLPKKPTAIKteGKPAEVKKMTAKSVPadlsrpkSTSTSSMKKT 806
Cdd:pfam17823   98 SEPATREGAADGAASRAL--------AAAASSSPSSAAQSLPAAIA--ALPSEAFSAPRAAAC-------RANASAAPRA 160
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755541  807 TTLSGTAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSA--KPSSTTPR--LSRLATNTSAPDLKNVRSKVGsteNIKHQ 882
Cdd:pfam17823  161 AIAAASAPHAASPAPRTAASSTTAASSTTAASSAPTTAAssAPATLTPArgISTAATATGHPAAGTALAAVG---NSSPA 237
                          170       180       190
                   ....*....|....*....|....*....|...
gi 1862755541  883 PGGGRAKVEKKTEAAATTRKPESNAVTKTAGPI 915
Cdd:pfam17823  238 AGTVTAAVGTVTPAALATLAAAAGTVASAAGTI 270
 
Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
926-955 1.84e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 65.12  E-value: 1.84e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 1862755541  926 VQIVSKKVSYSHIQSKCGSKDNIKHVPGGG 955
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
957-986 2.91e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 64.35  E-value: 2.91e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 1862755541  957 VQIQNKKVDISKVSSKCGSKANIKHKPGGG 986
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
988-1018 5.60e-09

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 52.41  E-value: 5.60e-09
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1862755541  988 VKIESQKLNFKeKAQAKVGSLDNVGHLPAGG 1018
Cdd:pfam00418    1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
865-886 2.93e-08

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 50.10  E-value: 2.93e-08
                           10        20
                   ....*....|....*....|..
gi 1862755541  865 DLKNVRSKVGSTENIKHQPGGG 886
Cdd:pfam00418    9 DFSKVQSKCGSKDNIKHKPGGG 30
PHA03247 PHA03247
large tegument protein UL36; Provisional
534-852 6.56e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.71  E-value: 6.56e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755541  534 DVPPLSETEATPVPIKDMEIAQTQKGISE-DSHLESLQDVGQSAAPTFMISPETVTGTGKKCSLPAEEDSVLeKLGERKP 612
Cdd:PHA03247  2590 DAPPQSARPRAPVDDRGDPRGPAPPSPLPpDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRV-SRPRRAR 2668
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755541  613 CNSQPSELSSETSGIARPEEGRPVVSGTGNDITTPPNKELPPSPEKKTKPAPTTIGGLNKKPMSLASglvPAAPPKRPAV 692
Cdd:PHA03247  2669 RLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPAL---PAAPAPPAVP 2745
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755541  693 ASArpsILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSgskSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIK 772
Cdd:PHA03247  2746 AGP---ATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRL---TRPAVASLSESRESLPSPWDPADPPAAVLAPAAALP 2819
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755541  773 TEGKPAEVKKMTAKSVPADLSRPKSTSTSSmkktTTLSGTAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTP 852
Cdd:PHA03247  2820 PAASPAGPLPPPTSAQPTAPPPPPGPPPPS----LPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRST 2895
PHA03247 PHA03247
large tegument protein UL36; Provisional
612-922 1.21e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.94  E-value: 1.21e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755541  612 PCNSQPSELSSETSGIARPEEGRPVVSG--TGNDITTPPNKELPPSPEKKTKPAPTTIGGLNKKPmslASGLVPAAPPKR 689
Cdd:PHA03247  2575 PRPSEPAVTSRARRPDAPPQSARPRAPVddRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPD---PHPPPTVPPPER 2651
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755541  690 PAVASARPSILPSKDVKPKpiadAKAPEKRASPSKPaSAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPT 769
Cdd:PHA03247  2652 PRDDPAPGRVSRPRRARRL----GRAAQASSPPQRP-RRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPA 2726
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755541  770 AIKTEGKPAevkkmtaksvPADLSRPKSTstssmkktttlsgTAPAAGVVPSRVKATPMPSRPSTTpfidkKPTSAKPSS 849
Cdd:PHA03247  2727 AARQASPAL----------PAAPAPPAVP-------------AGPATPGGPARPARPPTTAGPPAP-----APPAAPAAG 2778
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1862755541  850 TTPRLSRLATNTSAPDLKNVRSKVGSTENIkhQPGGGRAKVEKKTEAAATTRKPESnAVTKTAGPIASAQKQP 922
Cdd:PHA03247  2779 PPRRLTRPAVASLSESRESLPSPWDPADPP--AAVLAPAAALPPAASPAGPLPPPT-SAQPTAPPPPPGPPPP 2848
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
612-904 1.51e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 42.75  E-value: 1.51e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755541  612 PCNSQPSELSSETS-GIARPEEGRPVVSGTGNDITTPPNkelpPSPEKKtkpaPTTIGGLNKKPmslaSGLVPAAPPKRp 690
Cdd:PTZ00449   524 PGDKEGEEGEHEDSkESDEPKEGGKPGETKEGEVGKKPG----PAKEHK----PSKIPTLSKKP----EFPKDPKHPKD- 590
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755541  691 avasarpsilPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPsSRSPSTLLPKKPTA 770
Cdd:PTZ00449   591 ----------PEEPKKPKRPRSAQRPTRPKSPKLPELLDIPKSPKRPESPKSPKRPPPPQRPSSP-ERPEGPKIIKSPKP 659
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755541  771 IKTEGKP--AEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPM---PSRPSTTPFIDKKPtsA 845
Cdd:PTZ00449   660 PKSPKPPfdPKFKEKFYDDYLDAAAKSKETKTTVVLDESFESILKETLPETPGTPFTTPRplpPKLPRDEEFPFEPI--G 737
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755541  846 KPSSTTPRLSRLATntsAPDLKNVRSKvgstENIKHQPGGGRAKVEKKTE-AAATTRKPE 904
Cdd:PTZ00449   738 DPDAEQPDDIEFFT---PPEEERTFFH----ETPADTPLPDILAEEFKEEdIHAETGEPD 790
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
686-847 1.52e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 42.75  E-value: 1.52e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755541  686 PPKRPAvASARPsilpskdvkPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPS-----SRSP 760
Cdd:PTZ00449   510 PPEGPE-ASGLP---------PKAPGDKEGEEGEHEDSKESDEPKEGGKPGETKEGEVGKKPGPAKEHKPSkiptlSKKP 579
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755541  761 StlLPKKPTAIKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTL--SGTAPAAGVVPSRVKAtpmPSRPSTT--P 836
Cdd:PTZ00449   580 E--FPKDPKHPKDPEEPKKPKRPRSAQRPTRPKSPKLPELLDIPKSPKRpeSPKSPKRPPPPQRPSS---PERPEGPkiI 654
                          170
                   ....*....|.
gi 1862755541  837 FIDKKPTSAKP 847
Cdd:PTZ00449   655 KSPKPPKSPKP 665
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
611-733 2.88e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 41.62  E-value: 2.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755541  611 KPCNSQPSELSSETSGIARPEEGRPVVSgtgndittppnkelpPSPEKKTKPAPTTIGGLNKKPMslASGLVPAAPPKRP 690
Cdd:PRK14951   365 KPAAAAEAAAPAEKKTPARPEAAAPAAA---------------PVAQAAAAPAPAAAPAAAASAP--AAPPAAAPPAPVA 427
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1862755541  691 AVASARPSILPSKDVKPKPIADA----KAPEKRASPSKPASAPASRS 733
Cdd:PRK14951   428 APAAAAPAAAPAAAPAAVALAPAppaqAAPETVAIPVRVAPEPAVAS 474
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
612-856 3.27e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 41.70  E-value: 3.27e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755541  612 PCNSQPSELSSETSGIARPEEGRP--VVSGTGNDITTPPNKELPPSPEKKTKPAPTTIGGLNKKPMSLASGLVPAAPPKR 689
Cdd:PHA03307   148 PAASPPAAGASPAAVASDAASSRQaaLPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRS 227
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755541  690 PAV--ASARPSILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAaavaSTGPSSRSPSTLlPKK 767
Cdd:PHA03307   228 AADdaGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASS----SSSPRERSPSPS-PSS 302
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755541  768 PTAIKTEGKPAEVKKMTAKSvPADLSRPKSTSTSSMKKTTTlSGTAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKP 847
Cdd:PHA03307   303 PGSGPAPSSPRASSSSSSSR-ESSSSSTSSSSESSRGAAVS-PGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAA 380

                   ....*....
gi 1862755541  848 SSTTPRLSR 856
Cdd:PHA03307   381 SAGRPTRRR 389
PHA03247 PHA03247
large tegument protein UL36; Provisional
624-860 3.59e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.85  E-value: 3.59e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755541  624 TSGIARPEEGRPVVSGTGNDITTPPNKEL---------PPSPEKKTKPAPTTIGGLNKK-----PMSLASGLVPAAPPKR 689
Cdd:PHA03247  2763 TAGPPAPAPPAAPAAGPPRRLTRPAVASLsesreslpsPWDPADPPAAVLAPAAALPPAaspagPLPPPTSAQPTAPPPP 2842
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755541  690 PA-VASARP---SILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLP 765
Cdd:PHA03247  2843 PGpPPPSLPlggSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQ 2922
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755541  766 KKPTAIKTegkPAEVKKMTAKSVPADLSRPKSTSTSS-MKKTTTLSGTAPAAGVVPSRVKATPMPSRPSTTPfidkkPTS 844
Cdd:PHA03247  2923 PPPPPQPQ---PPPPPPPRPQPPLAPTTDPAGAGEPSgAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPAS-----STP 2994
                          250
                   ....*....|....*.
gi 1862755541  845 AKPSSTTPRLSRLATN 860
Cdd:PHA03247  2995 PLTGHSLSRVSSWASS 3010
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
662-923 4.25e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 41.37  E-value: 4.25e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755541  662 PAPTTIGGLNKKPMSLASGLVPAAPPKRPAVASAR-------PSILPSKDVKPKPIADA-----KAPEKRASPskPASAP 729
Cdd:PRK07003   360 PAVTGGGAPGGGVPARVAGAVPAPGARAAAAVGASavpavtaVTGAAGAALAPKAAAAAaatraEAPPAAPAP--PATAD 437
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755541  730 ASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTEGKPAEVKKmtAKSVPADLSRPKSTSTSSmkktttl 809
Cdd:PRK07003   438 RGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAF--EPAPRAAAPSAATPAAVP------- 508
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755541  810 sgtAPAAGVVPSRVKATPMPSRPSttpfidkkPTSAKPSSTTPRLSRLATNTSAP--DLKNVRSKVGSTeniKHQPGGGR 887
Cdd:PRK07003   509 ---DARAPAAASREDAPAAAAPPA--------PEARPPTPAAAAPAARAGGAAAAldVLRNAGMRVSSD---RGARAAAA 574
                          250       260       270
                   ....*....|....*....|....*....|....*.
gi 1862755541  888 AKVEKKTEAAATTRKPESNAVTKTAGPIASAQKQPA 923
Cdd:PRK07003   575 AKPAAAPAAAPKPAAPRVAVQVPTPRARAATGDAPP 610
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
727-915 5.07e-03

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 40.71  E-value: 5.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755541  727 SAPASRSGSKSTQTVAKTttaaavasTGPSSRSPSTLLPKKPTAIKteGKPAEVKKMTAKSVPadlsrpkSTSTSSMKKT 806
Cdd:pfam17823   98 SEPATREGAADGAASRAL--------AAAASSSPSSAAQSLPAAIA--ALPSEAFSAPRAAAC-------RANASAAPRA 160
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755541  807 TTLSGTAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSA--KPSSTTPR--LSRLATNTSAPDLKNVRSKVGsteNIKHQ 882
Cdd:pfam17823  161 AIAAASAPHAASPAPRTAASSTTAASSTTAASSAPTTAAssAPATLTPArgISTAATATGHPAAGTALAAVG---NSSPA 237
                          170       180       190
                   ....*....|....*....|....*....|...
gi 1862755541  883 PGGGRAKVEKKTEAAATTRKPESNAVTKTAGPI 915
Cdd:pfam17823  238 AGTVTAAVGTVTPAALATLAAAAGTVASAAGTI 270
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
527-864 5.90e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 40.67  E-value: 5.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755541  527 NNVTPAKDVPPLSETEAT-PVPikdmeiAQTQKGISEDSHLESLQDVGQSAAPTFMISPETVTGT---GKKCSLPA---- 598
Cdd:pfam05109  457 NLTAPASTGPTVSTADVTsPTP------AGTTSGASPVTPSPSPRDNGTESKAPDMTSPTSAVTTptpNATSPTPAvttp 530
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755541  599 EEDSVLEKLGERKPCNSQPSELSSETS-----GIARPEEGRPVVSGTG--NDITTP-PNKELPPSPEKKTKPAPT--TIG 668
Cdd:pfam05109  531 TPNATSPTLGKTSPTSAVTTPTPNATSptpavTTPTPNATIPTLGKTSptSAVTTPtPNATSPTVGETSPQANTTnhTLG 610
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755541  669 GLNKKPmslasglVPAAPPKRP--AVASARPSILPSK----DVKPKPIADAKAPEK--RASPSKPASAPASRSGSKSTQT 740
Cdd:pfam05109  611 GTSSTP-------VVTSPPKNAtsAVTTGQHNITSSStssmSLRPSSISETLSPSTsdNSTSHMPLLTSAHPTGGENITQ 683
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755541  741 VAKTTTAAAVASTG-PSSRSPSTLLPKKPTAIKTEGKPAEV--------KKMTAKSVPADLSRPKSTSTSSMKKTTTLSG 811
Cdd:pfam05109  684 VTPASTSTHHVSTSsPAPRPGTTSQASGPGNSSTSTKPGEVnvtkgtppKNATSPQAPSGQKTAVPTVTSTGGKANSTTG 763
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1862755541  812 TAPAAGVvPSRVKATPMPSR--PSTTPFIDKKPTSAKPSSTTPRLSRLATNTSAP 864
Cdd:pfam05109  764 GKHTTGH-GARTSTEPTTDYggDSTTPRTRYNATTYLPPSTSSKLRPRWTFTSPP 817
PRK08691 PRK08691
DNA polymerase III subunits gamma and tau; Validated
497-687 8.72e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236333 [Multi-domain]  Cd Length: 709  Bit Score: 40.08  E-value: 8.72e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755541  497 PEMEVALTEDQVP---ALKTEAPLAKDGVLTLANNVTPAKDVPPLSETEATPVPIKDmeiaqtqkgisedshlESLQDVG 573
Cdd:PRK08691   398 PEAETAQTPVQTAsaaAMPSEGKTAGPVSNQENNDVPPWEDAPDEAQTAAGTAQTSA----------------KSIQTAS 461
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862755541  574 QSAAPtfmisPETVTGTGKkcSLPAEEDSVLEKLGERKPCNSQPSELSSETSGIAR--PEEGRPVVSGTGNDITTPPNKE 651
Cdd:PRK08691   462 EAETP-----PENQVSKNK--AADNETDAPLSEVPSENPIQATPNDEAVETETFAHeaPAEPFYGYGFPDNDCPPEDGAE 534
                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 1862755541  652 LPPSPEKKTKPAPTTIGGL--NKKPMSLASGLVPAAPP 687
Cdd:PRK08691   535 IPPPDWEHAAPADTAGGGAdeEAEAGGIGGNNTPSAPP 572
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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