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Conserved domains on  [gi|1859877237|ref|NP_001371462|]
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transcriptional repressor p66-alpha isoform 2 [Homo sapiens]

Protein Classification

P66_CC and GATA domain-containing protein( domain architecture ID 10964881)

protein containing domains Med21, P66_CC, and GATA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
P66_CC pfam16563
Coiled-coil and interaction region of P66A and P66B with MBD2; This family is a short ...
 137-176 2.82e-16

Coiled-coil and interaction region of P66A and P66B with MBD2; This family is a short coiled-coil interaction region on the transcriptional repressors P66A and P66B. The P66A and B, or alpha and beta, complex with MBDs or methyl-binding domain-containing proteins via a coiled-coil region on each. This P66-MBD2 complex forms part of an assembly with NuRD, nucleosome remodelling and deacetylation protein. MBD2-NuRD binds methylated DNA and regulates transcription of eg, the foetal beta-globin gene during development.


:

Pssm-ID: 465178  Cd Length: 40  Bit Score: 72.84  E-value: 2.82e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1859877237 137 SPEERERMIKQLKEELRLEEAKLVLLKKLRQSQIQKEATA 176
Cdd:pfam16563   1 EIEERERMIKKLREELRLEEAKLVLLKKLRQSQQQKENIV 40
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 417-451 4.94e-08

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


:

Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 49.24  E-value: 4.94e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1859877237 417 CAQCKTDFTCRWREEKSGAI-MCENCMTTNQKKALK 451
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
Med21 super family cl12769
Subunit 21 of Mediator complex; Med21 has been known as Srb7 in yeasts, hSrb7 in humans and ...
 98-167 2.95e-03

Subunit 21 of Mediator complex; Med21 has been known as Srb7 in yeasts, hSrb7 in humans and Trap 19 in Drosophila. The heterodimer of the two subunits Med7 and Med21 appears to act as a hinge between the middle and the tail regions of Mediator.


The actual alignment was detected with superfamily member pfam11221:

Pssm-ID: 463241  Cd Length: 134  Bit Score: 38.34  E-value: 2.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859877237  98 PPSPDVIVLSDNEQPSSPRV--------NGL----TTVALKETSTEAL------MKSSPEERERMIKQLKEELRLEEAKL 159
Cdd:pfam11221  32 PLPPNDPISPDKAPPQPEPEpdppeefeATQrelaRDLILKAQQIEYLidslpgIGVSEEEQLQRIKELEEELREAEEER 111

                          90
                  ....*....|....*.
gi 1859877237 160 V--------LLKKLRQ 167
Cdd:pfam11221 112 QeavkekeeLLKKLDE 127
ser_rich_anae_1 super family cl41472
serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 ...
 513-620 4.16e-03

serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 amino acids), which a highly serine-rich central region that averages over 300 aa in length. Species encoding members of this family of proteins tend to be anaerobic bacteria, including Gram-positive bacteria of the human gut microbiome and Chloroflexi from marine sediments.


The actual alignment was detected with superfamily member NF033849:

Pssm-ID: 468206 [Multi-domain]  Cd Length: 1122  Bit Score: 40.37  E-value: 4.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859877237  513 GEARDWSNGAVLQASSQLSRGSA-TTPRGVLHTFSpspklqNSASATALVSR-TGRHSERTVSAGKGSATSNwkKTPLST 590
Cdd:NF033849   459 SQGTSWSEGTGTSQGQSVGTSESwSTSQSETDSVG------DSTGTSESVSQgDGRSTGRSESQGTSLGTSG--GRTSGA 530

                           90       100       110
                   ....*....|....*....|....*....|
gi 1859877237  591 GGTLAFVsPSLAVHKSSSAVDRQREYLLDM 620
Cdd:NF033849   531 GGSMGLG-PSISLGKSYQWEDDPAILLTEI 559
 
Name Accession Description Interval E-value
P66_CC pfam16563
Coiled-coil and interaction region of P66A and P66B with MBD2; This family is a short ...
 137-176 2.82e-16

Coiled-coil and interaction region of P66A and P66B with MBD2; This family is a short coiled-coil interaction region on the transcriptional repressors P66A and P66B. The P66A and B, or alpha and beta, complex with MBDs or methyl-binding domain-containing proteins via a coiled-coil region on each. This P66-MBD2 complex forms part of an assembly with NuRD, nucleosome remodelling and deacetylation protein. MBD2-NuRD binds methylated DNA and regulates transcription of eg, the foetal beta-globin gene during development.


Pssm-ID: 465178  Cd Length: 40  Bit Score: 72.84  E-value: 2.82e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1859877237 137 SPEERERMIKQLKEELRLEEAKLVLLKKLRQSQIQKEATA 176
Cdd:pfam16563   1 EIEERERMIKKLREELRLEEAKLVLLKKLRQSQQQKENIV 40
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 417-451 4.94e-08

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 49.24  E-value: 4.94e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1859877237 417 CAQCKTDFTCRWREEKSGAI-MCENCMTTNQKKALK 451
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
Med21 pfam11221
Subunit 21 of Mediator complex; Med21 has been known as Srb7 in yeasts, hSrb7 in humans and ...
 98-167 2.95e-03

Subunit 21 of Mediator complex; Med21 has been known as Srb7 in yeasts, hSrb7 in humans and Trap 19 in Drosophila. The heterodimer of the two subunits Med7 and Med21 appears to act as a hinge between the middle and the tail regions of Mediator.


Pssm-ID: 463241  Cd Length: 134  Bit Score: 38.34  E-value: 2.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859877237  98 PPSPDVIVLSDNEQPSSPRV--------NGL----TTVALKETSTEAL------MKSSPEERERMIKQLKEELRLEEAKL 159
Cdd:pfam11221  32 PLPPNDPISPDKAPPQPEPEpdppeefeATQrelaRDLILKAQQIEYLidslpgIGVSEEEQLQRIKELEEELREAEEER 111

                          90
                  ....*....|....*.
gi 1859877237 160 V--------LLKKLRQ 167
Cdd:pfam11221 112 QeavkekeeLLKKLDE 127
ser_rich_anae_1 NF033849
serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 ...
 513-620 4.16e-03

serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 amino acids), which a highly serine-rich central region that averages over 300 aa in length. Species encoding members of this family of proteins tend to be anaerobic bacteria, including Gram-positive bacteria of the human gut microbiome and Chloroflexi from marine sediments.


Pssm-ID: 468206 [Multi-domain]  Cd Length: 1122  Bit Score: 40.37  E-value: 4.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859877237  513 GEARDWSNGAVLQASSQLSRGSA-TTPRGVLHTFSpspklqNSASATALVSR-TGRHSERTVSAGKGSATSNwkKTPLST 590
Cdd:NF033849   459 SQGTSWSEGTGTSQGQSVGTSESwSTSQSETDSVG------DSTGTSESVSQgDGRSTGRSESQGTSLGTSG--GRTSGA 530

                           90       100       110
                   ....*....|....*....|....*....|
gi 1859877237  591 GGTLAFVsPSLAVHKSSSAVDRQREYLLDM 620
Cdd:NF033849   531 GGSMGLG-PSISLGKSYQWEDDPAILLTEI 559
 
Name Accession Description Interval E-value
P66_CC pfam16563
Coiled-coil and interaction region of P66A and P66B with MBD2; This family is a short ...
 137-176 2.82e-16

Coiled-coil and interaction region of P66A and P66B with MBD2; This family is a short coiled-coil interaction region on the transcriptional repressors P66A and P66B. The P66A and B, or alpha and beta, complex with MBDs or methyl-binding domain-containing proteins via a coiled-coil region on each. This P66-MBD2 complex forms part of an assembly with NuRD, nucleosome remodelling and deacetylation protein. MBD2-NuRD binds methylated DNA and regulates transcription of eg, the foetal beta-globin gene during development.


Pssm-ID: 465178  Cd Length: 40  Bit Score: 72.84  E-value: 2.82e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1859877237 137 SPEERERMIKQLKEELRLEEAKLVLLKKLRQSQIQKEATA 176
Cdd:pfam16563   1 EIEERERMIKKLREELRLEEAKLVLLKKLRQSQQQKENIV 40
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 417-451 4.94e-08

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 49.24  E-value: 4.94e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1859877237 417 CAQCKTDFTCRWREEKSGAI-MCENCMTTNQKKALK 451
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
Med21 pfam11221
Subunit 21 of Mediator complex; Med21 has been known as Srb7 in yeasts, hSrb7 in humans and ...
 98-167 2.95e-03

Subunit 21 of Mediator complex; Med21 has been known as Srb7 in yeasts, hSrb7 in humans and Trap 19 in Drosophila. The heterodimer of the two subunits Med7 and Med21 appears to act as a hinge between the middle and the tail regions of Mediator.


Pssm-ID: 463241  Cd Length: 134  Bit Score: 38.34  E-value: 2.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859877237  98 PPSPDVIVLSDNEQPSSPRV--------NGL----TTVALKETSTEAL------MKSSPEERERMIKQLKEELRLEEAKL 159
Cdd:pfam11221  32 PLPPNDPISPDKAPPQPEPEpdppeefeATQrelaRDLILKAQQIEYLidslpgIGVSEEEQLQRIKELEEELREAEEER 111

                          90
                  ....*....|....*.
gi 1859877237 160 V--------LLKKLRQ 167
Cdd:pfam11221 112 QeavkekeeLLKKLDE 127
ser_rich_anae_1 NF033849
serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 ...
 513-620 4.16e-03

serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 amino acids), which a highly serine-rich central region that averages over 300 aa in length. Species encoding members of this family of proteins tend to be anaerobic bacteria, including Gram-positive bacteria of the human gut microbiome and Chloroflexi from marine sediments.


Pssm-ID: 468206 [Multi-domain]  Cd Length: 1122  Bit Score: 40.37  E-value: 4.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859877237  513 GEARDWSNGAVLQASSQLSRGSA-TTPRGVLHTFSpspklqNSASATALVSR-TGRHSERTVSAGKGSATSNwkKTPLST 590
Cdd:NF033849   459 SQGTSWSEGTGTSQGQSVGTSESwSTSQSETDSVG------DSTGTSESVSQgDGRSTGRSESQGTSLGTSG--GRTSGA 530

                           90       100       110
                   ....*....|....*....|....*....|
gi 1859877237  591 GGTLAFVsPSLAVHKSSSAVDRQREYLLDM 620
Cdd:NF033849   531 GGSMGLG-PSISLGKSYQWEDDPAILLTEI 559
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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