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Conserved domains on  [gi|1858589209|ref|NP_001371284|]
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double-strand-break repair protein rad21-like protein 1 isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Rad21_Rec8_N pfam04825
N terminus of Rad21 / Rec8 like protein; This family represents a conserved N-terminal region ...
 1-100 4.01e-57

N terminus of Rad21 / Rec8 like protein; This family represents a conserved N-terminal region found in eukaryotic cohesins of the Rad21, Rec8 and Scc1 families. Members of this family mediate sister chromatid cohesion during mitosis and meiosis, as part of the cohesin complex. Cohesion is necessary for homologous recombination (including double-strand break repair) and correct chromatid segregation. These proteins may also be involved in chromosome condensation. Dissociation at the metaphase to anaphase transition causes loss of cohesion and chromatid segregation.


:

Pssm-ID: 461446  Cd Length: 104  Bit Score: 186.22  E-value: 4.01e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858589209   1 MFYTHVLMSKRGPLAKIWLAAHWEKKLTKAHVFECNLEITIEKILSPKVKIALRTSGHLLLGVVRIYNRKAKYLLADCSE 80
Cdd:pfam04825   1 MFYSHEILSKKGPLATVWLAATLGKKLSKKQILEVDIPKACETIINPEAPLALRLSGQLLLGVVRIYSRKAKYLLDDCNE 80

                          90       100
                  ....*....|....*....|
gi 1858589209  81 AFLKMKMTFCPGLVDLPKEN 100
Cdd:pfam04825  81 ALVKIKKAFRPGQVDLPAEG 100
Rad21_Rec8_M_NXP1-like cd21792
Middle HEAT-repeat binding domain found in Homo sapiens nuclear matrix protein 1 (NXP-1) and ...
 290-370 3.27e-29

Middle HEAT-repeat binding domain found in Homo sapiens nuclear matrix protein 1 (NXP-1) and similar proteins; NXP-1, also called double-strand-break repair protein Rad21 homolog (HR21), or Scc1 homolog, is related to Rad21/Scc1/Mcd1. As a component of the cohesin complex, it is involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post-replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions. The cohesin complex may also play a role in spindle pole assembly during mitosis. The family also includes double-strand-break repair protein rad21-like protein 1 (RAD21L), which is a meiosis-specific component of some cohesin complex required during the initial steps of prophase I in male meiosis. This model corresponds to the HEAT-repeat binding domain of NXP-1 located in the middle/central region, which consists of four short helices and two long extended segments. It is responsible for the binding of cohesin HEAT-repeat subunit SA2. The SA2:NXP-1 heterodimer mediates the binding between cohesin and its regulators, including Scc2-Scc4, Pds5, Wapl, and Sgo1.


:

Pssm-ID: 439294 [Multi-domain]  Cd Length: 81  Bit Score: 110.41  E-value: 3.27e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858589209 290 KRKGKKRRLLIDPIKELSSKVIHKQLTSFADTLMVLELAPPTQRLMMWKKRGGVHTLLSTAAQDLIHAELKMLFTKCFLS 369
Cdd:cd21792     1 KRRKRKRKLIVDTVKEISGEEMKAQLSDTSDIVTTLDLAPPTKKLMRWKETGGVDKLFSLPGRPILSSPLLKLFTRNLTS 80


                  .
gi 1858589209 370 S 370
Cdd:cd21792    81 G 81
Rad21_Rec8 pfam04824
Conserved region of Rad21 / Rec8 like protein; This family represents a conserved region found ...
 501-552 1.99e-15

Conserved region of Rad21 / Rec8 like protein; This family represents a conserved region found in eukaryotic cohesins of the Rad21, Rec8 and Scc1 families. Members of this family mediate sister chromatid cohesion during mitosis and meiosis, as part of the cohesin complex. Cohesion is necessary for homologous recombination (including double-strand break repair) and correct chromatid segregation. These proteins may also be involved in chromosome condensation. Dissociation at the metaphase to anaphase transition causes loss of cohesion and chromatid segregation.


:

Pssm-ID: 335912  Cd Length: 55  Bit Score: 70.44  E-value: 1.99e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1858589209 501 QSFSLMKLCRNSDRKQAAAKFYSFLVLKKQLAIELSQSAPYADIIATMGPMF 552
Cdd:pfam04824   4 EKDSLSLLPAGKTRKEAARLFYELLVLATKGAIKVKQEEPYGDILITPGPKF 55
 
Name Accession Description Interval E-value
Rad21_Rec8_N pfam04825
N terminus of Rad21 / Rec8 like protein; This family represents a conserved N-terminal region ...
 1-100 4.01e-57

N terminus of Rad21 / Rec8 like protein; This family represents a conserved N-terminal region found in eukaryotic cohesins of the Rad21, Rec8 and Scc1 families. Members of this family mediate sister chromatid cohesion during mitosis and meiosis, as part of the cohesin complex. Cohesion is necessary for homologous recombination (including double-strand break repair) and correct chromatid segregation. These proteins may also be involved in chromosome condensation. Dissociation at the metaphase to anaphase transition causes loss of cohesion and chromatid segregation.


Pssm-ID: 461446  Cd Length: 104  Bit Score: 186.22  E-value: 4.01e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858589209   1 MFYTHVLMSKRGPLAKIWLAAHWEKKLTKAHVFECNLEITIEKILSPKVKIALRTSGHLLLGVVRIYNRKAKYLLADCSE 80
Cdd:pfam04825   1 MFYSHEILSKKGPLATVWLAATLGKKLSKKQILEVDIPKACETIINPEAPLALRLSGQLLLGVVRIYSRKAKYLLDDCNE 80

                          90       100
                  ....*....|....*....|
gi 1858589209  81 AFLKMKMTFCPGLVDLPKEN 100
Cdd:pfam04825  81 ALVKIKKAFRPGQVDLPAEG 100
Rad21_Rec8_M_NXP1-like cd21792
Middle HEAT-repeat binding domain found in Homo sapiens nuclear matrix protein 1 (NXP-1) and ...
 290-370 3.27e-29

Middle HEAT-repeat binding domain found in Homo sapiens nuclear matrix protein 1 (NXP-1) and similar proteins; NXP-1, also called double-strand-break repair protein Rad21 homolog (HR21), or Scc1 homolog, is related to Rad21/Scc1/Mcd1. As a component of the cohesin complex, it is involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post-replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions. The cohesin complex may also play a role in spindle pole assembly during mitosis. The family also includes double-strand-break repair protein rad21-like protein 1 (RAD21L), which is a meiosis-specific component of some cohesin complex required during the initial steps of prophase I in male meiosis. This model corresponds to the HEAT-repeat binding domain of NXP-1 located in the middle/central region, which consists of four short helices and two long extended segments. It is responsible for the binding of cohesin HEAT-repeat subunit SA2. The SA2:NXP-1 heterodimer mediates the binding between cohesin and its regulators, including Scc2-Scc4, Pds5, Wapl, and Sgo1.


Pssm-ID: 439294 [Multi-domain]  Cd Length: 81  Bit Score: 110.41  E-value: 3.27e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858589209 290 KRKGKKRRLLIDPIKELSSKVIHKQLTSFADTLMVLELAPPTQRLMMWKKRGGVHTLLSTAAQDLIHAELKMLFTKCFLS 369
Cdd:cd21792     1 KRRKRKRKLIVDTVKEISGEEMKAQLSDTSDIVTTLDLAPPTKKLMRWKETGGVDKLFSLPGRPILSSPLLKLFTRNLTS 80


                  .
gi 1858589209 370 S 370
Cdd:cd21792    81 G 81
Rad21_Rec8 pfam04824
Conserved region of Rad21 / Rec8 like protein; This family represents a conserved region found ...
 501-552 1.99e-15

Conserved region of Rad21 / Rec8 like protein; This family represents a conserved region found in eukaryotic cohesins of the Rad21, Rec8 and Scc1 families. Members of this family mediate sister chromatid cohesion during mitosis and meiosis, as part of the cohesin complex. Cohesion is necessary for homologous recombination (including double-strand break repair) and correct chromatid segregation. These proteins may also be involved in chromosome condensation. Dissociation at the metaphase to anaphase transition causes loss of cohesion and chromatid segregation.


Pssm-ID: 335912  Cd Length: 55  Bit Score: 70.44  E-value: 1.99e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1858589209 501 QSFSLMKLCRNSDRKQAAAKFYSFLVLKKQLAIELSQSAPYADIIATMGPMF 552
Cdd:pfam04824   4 EKDSLSLLPAGKTRKEAARLFYELLVLATKGAIKVKQEEPYGDILITPGPKF 55
 
Name Accession Description Interval E-value
Rad21_Rec8_N pfam04825
N terminus of Rad21 / Rec8 like protein; This family represents a conserved N-terminal region ...
 1-100 4.01e-57

N terminus of Rad21 / Rec8 like protein; This family represents a conserved N-terminal region found in eukaryotic cohesins of the Rad21, Rec8 and Scc1 families. Members of this family mediate sister chromatid cohesion during mitosis and meiosis, as part of the cohesin complex. Cohesion is necessary for homologous recombination (including double-strand break repair) and correct chromatid segregation. These proteins may also be involved in chromosome condensation. Dissociation at the metaphase to anaphase transition causes loss of cohesion and chromatid segregation.


Pssm-ID: 461446  Cd Length: 104  Bit Score: 186.22  E-value: 4.01e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858589209   1 MFYTHVLMSKRGPLAKIWLAAHWEKKLTKAHVFECNLEITIEKILSPKVKIALRTSGHLLLGVVRIYNRKAKYLLADCSE 80
Cdd:pfam04825   1 MFYSHEILSKKGPLATVWLAATLGKKLSKKQILEVDIPKACETIINPEAPLALRLSGQLLLGVVRIYSRKAKYLLDDCNE 80

                          90       100
                  ....*....|....*....|
gi 1858589209  81 AFLKMKMTFCPGLVDLPKEN 100
Cdd:pfam04825  81 ALVKIKKAFRPGQVDLPAEG 100
Rad21_Rec8_M_NXP1-like cd21792
Middle HEAT-repeat binding domain found in Homo sapiens nuclear matrix protein 1 (NXP-1) and ...
 290-370 3.27e-29

Middle HEAT-repeat binding domain found in Homo sapiens nuclear matrix protein 1 (NXP-1) and similar proteins; NXP-1, also called double-strand-break repair protein Rad21 homolog (HR21), or Scc1 homolog, is related to Rad21/Scc1/Mcd1. As a component of the cohesin complex, it is involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post-replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions. The cohesin complex may also play a role in spindle pole assembly during mitosis. The family also includes double-strand-break repair protein rad21-like protein 1 (RAD21L), which is a meiosis-specific component of some cohesin complex required during the initial steps of prophase I in male meiosis. This model corresponds to the HEAT-repeat binding domain of NXP-1 located in the middle/central region, which consists of four short helices and two long extended segments. It is responsible for the binding of cohesin HEAT-repeat subunit SA2. The SA2:NXP-1 heterodimer mediates the binding between cohesin and its regulators, including Scc2-Scc4, Pds5, Wapl, and Sgo1.


Pssm-ID: 439294 [Multi-domain]  Cd Length: 81  Bit Score: 110.41  E-value: 3.27e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858589209 290 KRKGKKRRLLIDPIKELSSKVIHKQLTSFADTLMVLELAPPTQRLMMWKKRGGVHTLLSTAAQDLIHAELKMLFTKCFLS 369
Cdd:cd21792     1 KRRKRKRKLIVDTVKEISGEEMKAQLSDTSDIVTTLDLAPPTKKLMRWKETGGVDKLFSLPGRPILSSPLLKLFTRNLTS 80


                  .
gi 1858589209 370 S 370
Cdd:cd21792    81 G 81
Rad21_Rec8 pfam04824
Conserved region of Rad21 / Rec8 like protein; This family represents a conserved region found ...
 501-552 1.99e-15

Conserved region of Rad21 / Rec8 like protein; This family represents a conserved region found in eukaryotic cohesins of the Rad21, Rec8 and Scc1 families. Members of this family mediate sister chromatid cohesion during mitosis and meiosis, as part of the cohesin complex. Cohesion is necessary for homologous recombination (including double-strand break repair) and correct chromatid segregation. These proteins may also be involved in chromosome condensation. Dissociation at the metaphase to anaphase transition causes loss of cohesion and chromatid segregation.


Pssm-ID: 335912  Cd Length: 55  Bit Score: 70.44  E-value: 1.99e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1858589209 501 QSFSLMKLCRNSDRKQAAAKFYSFLVLKKQLAIELSQSAPYADIIATMGPMF 552
Cdd:pfam04824   4 EKDSLSLLPAGKTRKEAARLFYELLVLATKGAIKVKQEEPYGDILITPGPKF 55
Rad21_Rec8_M cd21747
Middle HEAT-repeat binding domain of Rad21/Rec8-like proteins; This family includes eukaryotic ...
 291-367 3.65e-08

Middle HEAT-repeat binding domain of Rad21/Rec8-like proteins; This family includes eukaryotic cohesins of the Rad21, Rec8, and Scc1 subfamilies. They mediate sister chromatid cohesion during mitosis and meiosis, as part of the cohesin complex. Cohesion is necessary for homologous recombination (including double-strand break repair) and correct chromatid segregation. These proteins may also be involved in chromosome condensation. Dissociation at the metaphase to anaphase transition causes loss of cohesion and chromatid segregation. This model corresponds to a conserved middle/central region of family members, consisting of short helices and two extended segments, which functions in binding to HEAT-repeat containing cohesin subunits. For example, human Scc1 homolog (NXP-1) binds to either SA1 or SA2, two homologous HEAT-containing proteins; the SA-Scc1 heterodimer mediates the binding between cohesin and its regulators, including Scc2-Scc4, Pds5, Wapl, and Sgo1.


Pssm-ID: 439289 [Multi-domain]  Cd Length: 79  Bit Score: 50.54  E-value: 3.65e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1858589209 291 RKGKKRRLLIDPIKELSSKVIHKQLTSFADTLMVLELAPPTQRLMMwKKRGGVHTLLSTAAQDLIHAELKMLFTKCF 367
Cdd:cd21747     1 RRRRKRKLLIDEVTELSTEQMRSQLQDTSDIVRSRDLNPPTPVRPL-RKASGTDSLFSLNPLSGWDNALLELFPSPL 76
Rad21_Rec8_M_SpRad21p-like cd21788
Middle HEAT-repeat binding domain found in Schizosaccharomyces pombe cohesin subunit rad21 ...
 291-367 6.54e-05

Middle HEAT-repeat binding domain found in Schizosaccharomyces pombe cohesin subunit rad21 (SpRad21p) and similar proteins; SpRad21p, also called double-strand-break (DSB) repair protein rad21, or SCC1 homolog, is a cleavable component of the cohesin complex, involved in chromosome cohesion during the cell cycle. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. It apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At the metaphase-anaphase transition, SpRad21p is cleaved by cut1 and dissociates from chromatin, allowing sister chromatids to segregate. It is also involved in the DNA DSB repair system. This model corresponds to a small region in the middle of SpRad21p that shows high sequence similarity with the HEAT-repeat binding domain found in both Saccharomyces cerevisiae sister chromatid cohesion protein 1 (ScScc1p) and Homo sapiens nuclear matrix protein 1 (NXP-1), which consists of short helices and two long extended segments.


Pssm-ID: 439290 [Multi-domain]  Cd Length: 85  Bit Score: 41.50  E-value: 6.54e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1858589209 291 RKGKKRRLLIDPIKELSSKVIHKQLTSFADTLMVLELAPPTQRLM--MWKKRGGVHTLLSTaAQDLIHAELKMLFTKCF 367
Cdd:cd21788     1 ARRRKRKLIVDSVTELPSAQLKAQLRDTSDILKKETFLPRDPKLLrlVELRDDGGNALTLP-APPGLAPELRGLFSRDF 78
Rad21_Rec8_M_Rec8 cd21794
Middle HEAT-repeat binding domain found in Homo sapiens meiotic recombination protein REC8 ...
 291-366 8.39e-03

Middle HEAT-repeat binding domain found in Homo sapiens meiotic recombination protein REC8 homolog and similar proteins; Rec8, also called cohesin Rec8p, is a meiotic recombination and sister chromatid cohesion phosphoprotein of the Rad21p family conserved from fission yeast to humans. It is required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of Rec8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I, and cleavage of Rec8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II. This model corresponds to a small region in the middle of Rec8 that shows high sequence similarity with the HEAT-repeat binding domain found in both the middle of Saccharomyces cerevisiae sister chromatid cohesion protein 1 (ScScc1p) and Homo sapiens nuclear matrix protein 1 (NXP-1), which consists of short helices and two long extended segments.


Pssm-ID: 439296 [Multi-domain]  Cd Length: 75  Bit Score: 35.36  E-value: 8.39e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1858589209 291 RKGKKRRLLIDPIKELSSKVIHKQLTSFADTL-MVLELAPPTQRLmmwkkrgGVHTLLST-AAQDLIHAELKMLFTKC 366
Cdd:cd21794     1 RRRRRRRLIIDENTQLSKEELRKNMQNVTSTRtMVPLVLPLLRPP-------SAAELFSRpGRKLLWSPKLLRLWRRN 71
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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