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Conserved domains on  [gi|1846471274|ref|NP_001371040|]
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DENN domain-containing protein 1C isoform 6 [Mus musculus]

Protein Classification

DENN domain-containing protein( domain architecture ID 10655338)

DENN domain-containing protein may be involved in Rab-mediated processes or regulation of mitogen-activated protein kinase (MAPK) signalling pathways

CATH:  3.40.50.11500|3.30.450.200
Gene Ontology:  GO:0005085|GO:0032483
PubMed:  11563850|21330364
SCOP:  4007417|4006687

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 91-293 7.05e-62

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 214823  Cd Length: 183  Bit Score: 205.12  E-value: 7.05e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846471274   91 ARSCLCILSHFPWFEVFYKILNNVGDLLAQNQVAEaEELLQNLQQHPLLGPRFSGRSemdssitvrsecGILPPalgnsK 170
Cdd:smart00799   1 APKCICILSRLPFFELFRKILNELYRLLPSSSNLP-LELLISLLLYPVPPPGGSLVL------------VSLGP-----G 62

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846471274  171 LLSCFVAPDAASLPSIPenRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTACVHASCALLYPMRWEHVLIPT 250
Cdd:smart00799  63 DLIELQRPLDSSLPLID--FSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPI 140

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1846471274  251 LPPHLLDYCCAPMPYLIGVHGSLAERVREKALEDVVVLNADSN 293
Cdd:smart00799 141 LPASLLDVLSAPTPFIIGVHSSYFEEVKELPDEDVVVVDLDTG 183
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 13-87 3.20e-19

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 214824  Cd Length: 89  Bit Score: 82.77  E-value: 3.20e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846471274   13 FDWFFEAGC-----PNSLEEDPPILRQFPP-DFQEQEAMQMVPRFCFPFDIEREPP--SPAVQHFTFALTDLVGNRRFGF 84
Cdd:smart00800   5 FDYFVVVGLdsdtgPLGRSYKPEILQRYPEkDFEDFPLPDSIPLFCFPEGLDFVTQtsSKDPQFFSFVLTDIDGSRRYGF 84


                   ...
gi 1846471274   85 CRL 87
Cdd:smart00800  85 CLR 87
 
Name Accession Description Interval E-value
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 91-293 7.05e-62

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 205.12  E-value: 7.05e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846471274   91 ARSCLCILSHFPWFEVFYKILNNVGDLLAQNQVAEaEELLQNLQQHPLLGPRFSGRSemdssitvrsecGILPPalgnsK 170
Cdd:smart00799   1 APKCICILSRLPFFELFRKILNELYRLLPSSSNLP-LELLISLLLYPVPPPGGSLVL------------VSLGP-----G 62

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846471274  171 LLSCFVAPDAASLPSIPenRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTACVHASCALLYPMRWEHVLIPT 250
Cdd:smart00799  63 DLIELQRPLDSSLPLID--FSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPI 140

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1846471274  251 LPPHLLDYCCAPMPYLIGVHGSLAERVREKALEDVVVLNADSN 293
Cdd:smart00799 141 LPASLLDVLSAPTPFIIGVHSSYFEEVKELPDEDVVVVDLDTG 183
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 94-293 1.11e-36

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 136.16  E-value: 1.11e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846471274  94 CLCILSHFPWFEVFYKILNNVGDLLaqnQVAEAEELLQNLQQHPLLGPRFSgrsemDSSITVRsecgiLPPALGNSKLLS 173
Cdd:pfam02141   5 AYCIISRLPFFNLFKKFLDELYRRR---TISPLPNPIERFIANLLYEVPFP-----PPGRTQK-----LKPLGGTEPILL 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846471274 174 CFvaPDAASLPSipENRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTACVHASCALLYPMRWEHVLIPTLPP 253
Cdd:pfam02141  72 QR--PEDSELPL--EGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPA 147

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1846471274 254 HLLDYCCAPMPYLIGVHGSLAErVREKALEDVVVLNADSN 293
Cdd:pfam02141 148 SLLDVLSAPTPFIIGVHSRYFD-LLEDPLDDVVLVDLDTG 186
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 13-87 3.20e-19

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214824  Cd Length: 89  Bit Score: 82.77  E-value: 3.20e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846471274   13 FDWFFEAGC-----PNSLEEDPPILRQFPP-DFQEQEAMQMVPRFCFPFDIEREPP--SPAVQHFTFALTDLVGNRRFGF 84
Cdd:smart00800   5 FDYFVVVGLdsdtgPLGRSYKPEILQRYPEkDFEDFPLPDSIPLFCFPEGLDFVTQtsSKDPQFFSFVLTDIDGSRRYGF 84


                   ...
gi 1846471274   85 CRL 87
Cdd:smart00800  85 CLR 87
uDENN pfam03456
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
 29-87 1.66e-12

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


Pssm-ID: 460926  Cd Length: 59  Bit Score: 62.63  E-value: 1.66e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846471274  29 PPILRQFPPDFQEQEAM-QMVPRFCFPFDIEREPPSPaVQHFTFALTDLVGNRRFGFCRL 87
Cdd:pfam03456   1 PEVLDRYPEDDWSDPPLpDGIPMFCFPEGLETLSSRE-PTFFSFVLTDEDGSRLYGACLT 59
 
Name Accession Description Interval E-value
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 91-293 7.05e-62

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 205.12  E-value: 7.05e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846471274   91 ARSCLCILSHFPWFEVFYKILNNVGDLLAQNQVAEaEELLQNLQQHPLLGPRFSGRSemdssitvrsecGILPPalgnsK 170
Cdd:smart00799   1 APKCICILSRLPFFELFRKILNELYRLLPSSSNLP-LELLISLLLYPVPPPGGSLVL------------VSLGP-----G 62

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846471274  171 LLSCFVAPDAASLPSIPenRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTACVHASCALLYPMRWEHVLIPT 250
Cdd:smart00799  63 DLIELQRPLDSSLPLID--FSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPI 140

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1846471274  251 LPPHLLDYCCAPMPYLIGVHGSLAERVREKALEDVVVLNADSN 293
Cdd:smart00799 141 LPASLLDVLSAPTPFIIGVHSSYFEEVKELPDEDVVVVDLDTG 183
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 94-293 1.11e-36

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 136.16  E-value: 1.11e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846471274  94 CLCILSHFPWFEVFYKILNNVGDLLaqnQVAEAEELLQNLQQHPLLGPRFSgrsemDSSITVRsecgiLPPALGNSKLLS 173
Cdd:pfam02141   5 AYCIISRLPFFNLFKKFLDELYRRR---TISPLPNPIERFIANLLYEVPFP-----PPGRTQK-----LKPLGGTEPILL 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846471274 174 CFvaPDAASLPSipENRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTACVHASCALLYPMRWEHVLIPTLPP 253
Cdd:pfam02141  72 QR--PEDSELPL--EGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPA 147

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1846471274 254 HLLDYCCAPMPYLIGVHGSLAErVREKALEDVVVLNADSN 293
Cdd:pfam02141 148 SLLDVLSAPTPFIIGVHSRYFD-LLEDPLDDVVLVDLDTG 186
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 13-87 3.20e-19

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214824  Cd Length: 89  Bit Score: 82.77  E-value: 3.20e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846471274   13 FDWFFEAGC-----PNSLEEDPPILRQFPP-DFQEQEAMQMVPRFCFPFDIEREPP--SPAVQHFTFALTDLVGNRRFGF 84
Cdd:smart00800   5 FDYFVVVGLdsdtgPLGRSYKPEILQRYPEkDFEDFPLPDSIPLFCFPEGLDFVTQtsSKDPQFFSFVLTDIDGSRRYGF 84


                   ...
gi 1846471274   85 CRL 87
Cdd:smart00800  85 CLR 87
uDENN pfam03456
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
 29-87 1.66e-12

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


Pssm-ID: 460926  Cd Length: 59  Bit Score: 62.63  E-value: 1.66e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846471274  29 PPILRQFPPDFQEQEAM-QMVPRFCFPFDIEREPPSPaVQHFTFALTDLVGNRRFGFCRL 87
Cdd:pfam03456   1 PEVLDRYPEDDWSDPPLpDGIPMFCFPEGLETLSSRE-PTFFSFVLTDEDGSRLYGACLT 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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