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Conserved domains on  [gi|1845977562|ref|NP_001370669|]
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Serine incorporator 1 [Caenorhabditis elegans]

Protein Classification

serine incorporator domain-containing protein( domain architecture ID 10505724)

serine incorporator domain-containing protein similar to Homo sapiens serine incorporators that may incorporate serine into membranes and facilitate the synthesis of serine-derived lipids such as phosphatidylserine, and to Saccharomyces cerevisiae membrane protein TMS1

Gene Ontology:  GO:0016020
PubMed:  16120614|31907454

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Serinc pfam03348
Serine incorporator (Serinc); This is a family of eukaryotic membrane proteins which ...
 18-451 0e+00

Serine incorporator (Serinc); This is a family of eukaryotic membrane proteins which incorporate serine into membranes and facilitate the synthesis of the serine-derived lipids phosphatidylserine and sphingolipid. Members of this family contain 11 transmembrane domains and form intracellular complexes with key enzymes involved in serine and sphingolipid biosynthesis.


:

Pssm-ID: 460891  Cd Length: 434  Bit Score: 527.52  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845977562  18 FGSAACSLCCSICPTTKSSTTTRIMYAFLLFTSTFLSCIMLLPGIQNKLAENKW---FCEGLNeyAGISCAhatGFQAVY 94
Cdd:pfam03348   4 CGSAACSLCCSCCPSCKSSTSTRLAYALLLLLNSLVSWIMLSPWVQKKLKKLSLkwpGCPGGK--GGGECY---GYSAVY 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845977562  95 RVCAATASFYLLFMLIMIGVKDSKDGRSSIQNGFWFFKYLILGALIVGFFFIrSESLATPLMYIGLIGGFMFILIQLILI 174
Cdd:pfam03348  79 RVCFALALFFLLLALLLIGVKSSKDPRAAIQNGFWFFKFLALLGLVVGAFFI-PNGFFTFWGYIGLIGGFLFILIQLILL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845977562 175 VDFAHGLAEAWVTSYEESESNYCYAGLLVTVFGGFALALTAVIIMYIYYAsGEGCGLPRFFVIFNTLLCVGLTALSLAPA 254
Cdd:pfam03348 158 VDFAHSWNESWVEKYEETNSKLWYAALLGSTLLMYALAIALTVLMYIFFT-GSGCGLNKFFISINLILCVIVSVVSILPK 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845977562 255 VQEVSPRSGLVQAVMITGYVMYLTWAALINNP-DKACNPSLISIFTGNstdpshktdeghygiplPAQSIVSLFLWFACL 333
Cdd:pfam03348 237 VQEANPRSGLLQSSVVSLYCTYLTWSALSSEPdDKNCNPLLRSSEGTR-----------------TASVVLGAIFTFLCV 299

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845977562 334 LYASIRNSSNTSLGKITGGGNTSD---------------EAIQLTDDAESQNSKRVYDNEEEGVAYSYSFFHFMFALASL 398
Cdd:pfam03348 300 AYSTTRAASNSAVLGLQGSGTTQEgsrdslrfealraavEEGSLPASALDDDGGKVLDDEKEGVAYSYSFFHFIFFLASL 379

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1845977562 399 YVMMTLTSWYKP--SNDLSHLNSNMASVWVKIVSSWVCVALYCWTLVAPIIYPDR 451
Cdd:pfam03348 380 YVAMLLTNWYSPddAGDFTPVGRSWAAVWVKIVSSWVCYLLYIWTLVAPLVLPDR 434
 
Name Accession Description Interval E-value
Serinc pfam03348
Serine incorporator (Serinc); This is a family of eukaryotic membrane proteins which ...
 18-451 0e+00

Serine incorporator (Serinc); This is a family of eukaryotic membrane proteins which incorporate serine into membranes and facilitate the synthesis of the serine-derived lipids phosphatidylserine and sphingolipid. Members of this family contain 11 transmembrane domains and form intracellular complexes with key enzymes involved in serine and sphingolipid biosynthesis.


Pssm-ID: 460891  Cd Length: 434  Bit Score: 527.52  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845977562  18 FGSAACSLCCSICPTTKSSTTTRIMYAFLLFTSTFLSCIMLLPGIQNKLAENKW---FCEGLNeyAGISCAhatGFQAVY 94
Cdd:pfam03348   4 CGSAACSLCCSCCPSCKSSTSTRLAYALLLLLNSLVSWIMLSPWVQKKLKKLSLkwpGCPGGK--GGGECY---GYSAVY 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845977562  95 RVCAATASFYLLFMLIMIGVKDSKDGRSSIQNGFWFFKYLILGALIVGFFFIrSESLATPLMYIGLIGGFMFILIQLILI 174
Cdd:pfam03348  79 RVCFALALFFLLLALLLIGVKSSKDPRAAIQNGFWFFKFLALLGLVVGAFFI-PNGFFTFWGYIGLIGGFLFILIQLILL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845977562 175 VDFAHGLAEAWVTSYEESESNYCYAGLLVTVFGGFALALTAVIIMYIYYAsGEGCGLPRFFVIFNTLLCVGLTALSLAPA 254
Cdd:pfam03348 158 VDFAHSWNESWVEKYEETNSKLWYAALLGSTLLMYALAIALTVLMYIFFT-GSGCGLNKFFISINLILCVIVSVVSILPK 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845977562 255 VQEVSPRSGLVQAVMITGYVMYLTWAALINNP-DKACNPSLISIFTGNstdpshktdeghygiplPAQSIVSLFLWFACL 333
Cdd:pfam03348 237 VQEANPRSGLLQSSVVSLYCTYLTWSALSSEPdDKNCNPLLRSSEGTR-----------------TASVVLGAIFTFLCV 299

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845977562 334 LYASIRNSSNTSLGKITGGGNTSD---------------EAIQLTDDAESQNSKRVYDNEEEGVAYSYSFFHFMFALASL 398
Cdd:pfam03348 300 AYSTTRAASNSAVLGLQGSGTTQEgsrdslrfealraavEEGSLPASALDDDGGKVLDDEKEGVAYSYSFFHFIFFLASL 379

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1845977562 399 YVMMTLTSWYKP--SNDLSHLNSNMASVWVKIVSSWVCVALYCWTLVAPIIYPDR 451
Cdd:pfam03348 380 YVAMLLTNWYSPddAGDFTPVGRSWAAVWVKIVSSWVCYLLYIWTLVAPLVLPDR 434
 
Name Accession Description Interval E-value
Serinc pfam03348
Serine incorporator (Serinc); This is a family of eukaryotic membrane proteins which ...
 18-451 0e+00

Serine incorporator (Serinc); This is a family of eukaryotic membrane proteins which incorporate serine into membranes and facilitate the synthesis of the serine-derived lipids phosphatidylserine and sphingolipid. Members of this family contain 11 transmembrane domains and form intracellular complexes with key enzymes involved in serine and sphingolipid biosynthesis.


Pssm-ID: 460891  Cd Length: 434  Bit Score: 527.52  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845977562  18 FGSAACSLCCSICPTTKSSTTTRIMYAFLLFTSTFLSCIMLLPGIQNKLAENKW---FCEGLNeyAGISCAhatGFQAVY 94
Cdd:pfam03348   4 CGSAACSLCCSCCPSCKSSTSTRLAYALLLLLNSLVSWIMLSPWVQKKLKKLSLkwpGCPGGK--GGGECY---GYSAVY 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845977562  95 RVCAATASFYLLFMLIMIGVKDSKDGRSSIQNGFWFFKYLILGALIVGFFFIrSESLATPLMYIGLIGGFMFILIQLILI 174
Cdd:pfam03348  79 RVCFALALFFLLLALLLIGVKSSKDPRAAIQNGFWFFKFLALLGLVVGAFFI-PNGFFTFWGYIGLIGGFLFILIQLILL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845977562 175 VDFAHGLAEAWVTSYEESESNYCYAGLLVTVFGGFALALTAVIIMYIYYAsGEGCGLPRFFVIFNTLLCVGLTALSLAPA 254
Cdd:pfam03348 158 VDFAHSWNESWVEKYEETNSKLWYAALLGSTLLMYALAIALTVLMYIFFT-GSGCGLNKFFISINLILCVIVSVVSILPK 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845977562 255 VQEVSPRSGLVQAVMITGYVMYLTWAALINNP-DKACNPSLISIFTGNstdpshktdeghygiplPAQSIVSLFLWFACL 333
Cdd:pfam03348 237 VQEANPRSGLLQSSVVSLYCTYLTWSALSSEPdDKNCNPLLRSSEGTR-----------------TASVVLGAIFTFLCV 299

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845977562 334 LYASIRNSSNTSLGKITGGGNTSD---------------EAIQLTDDAESQNSKRVYDNEEEGVAYSYSFFHFMFALASL 398
Cdd:pfam03348 300 AYSTTRAASNSAVLGLQGSGTTQEgsrdslrfealraavEEGSLPASALDDDGGKVLDDEKEGVAYSYSFFHFIFFLASL 379

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1845977562 399 YVMMTLTSWYKP--SNDLSHLNSNMASVWVKIVSSWVCVALYCWTLVAPIIYPDR 451
Cdd:pfam03348 380 YVAMLLTNWYSPddAGDFTPVGRSWAAVWVKIVSSWVCYLLYIWTLVAPLVLPDR 434
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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