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Conserved domains on  [gi|1845980918|ref|NP_001370550|]
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Next to BRCA1 central domain-containing protein [Caenorhabditis elegans]

Protein Classification

UBA_CF106 and NBR1_like domain-containing protein( domain architecture ID 10198741)

UBA_CF106 and NBR1_like domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NBR1_like cd14947
Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins; NBR1 has ...
 99-187 2.53e-20

Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins; NBR1 has been characterized as a specific late endosomal protein, which might play a role in receptor (RTK) trafficking. Specifically, NBR1 was shown to inhibit ligand-mediated receptor internalization from the cell surface. The region covered by this domain model may be involved in that function, as the C-terminus (which contains a UBA domain) was shown to be essential but not sufficient by itself. In an earlier yeast two-hybrid study, the region in mouse NBR1 covered by this domain has been shown to interact with CIB (calcium and integrin-binding protein) and FEZ1 (fasciculation and elongation protein zeta-1). Thus, NBR1 may play a role in cellular signalling pathways and possibly in neural development.


:

Pssm-ID: 271343 [Multi-domain]  Cd Length: 112  Bit Score: 82.72  E-value: 2.53e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980918  99 PNSTFFCGWRVVNDGRFRWPDGTRLAFVDGDPIDYEVWKD---TVLDPDQSENIEIRISCPAEMGDFKARFQFVTPQNFF 175
Cdd:cd14947    21 PGTEFTKTWRLRNTGTVPWPAGTLLRFVGGDPGLLSAPERvpvPSTVPGEEVDVSVELRAPSEPGRYISYWRLVTPDGLP 100

                          90
                  ....*....|..
gi 1845980918 176 FGESIWVIIRVR 187
Cdd:cd14947   101 FGDRLWVDITVE 112
UBA_CF106 cd14349
UBA-like domain found in uncharacterized protein C6orf106 and similar proteins; The family ...
 19-61 2.84e-12

UBA-like domain found in uncharacterized protein C6orf106 and similar proteins; The family corresponds to a group of uncharacterized protein C6orf106 and its homologs mainly found in Metazoa. All family members contain a ubiquitin-associated (UBA)-like domain.


:

Pssm-ID: 270534  Cd Length: 41  Bit Score: 59.54  E-value: 2.84e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1845980918  19 DRENLIHKFEEIISPQmiPHDLAAFYLDLANWNLSTAISVFYD 61
Cdd:cd14349     1 DHEELISQFQSILGAQ--NESEAAFFLEMNNWNLQAAVGAYFD 41
 
Name Accession Description Interval E-value
NBR1_like cd14947
Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins; NBR1 has ...
 99-187 2.53e-20

Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins; NBR1 has been characterized as a specific late endosomal protein, which might play a role in receptor (RTK) trafficking. Specifically, NBR1 was shown to inhibit ligand-mediated receptor internalization from the cell surface. The region covered by this domain model may be involved in that function, as the C-terminus (which contains a UBA domain) was shown to be essential but not sufficient by itself. In an earlier yeast two-hybrid study, the region in mouse NBR1 covered by this domain has been shown to interact with CIB (calcium and integrin-binding protein) and FEZ1 (fasciculation and elongation protein zeta-1). Thus, NBR1 may play a role in cellular signalling pathways and possibly in neural development.


Pssm-ID: 271343 [Multi-domain]  Cd Length: 112  Bit Score: 82.72  E-value: 2.53e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980918  99 PNSTFFCGWRVVNDGRFRWPDGTRLAFVDGDPIDYEVWKD---TVLDPDQSENIEIRISCPAEMGDFKARFQFVTPQNFF 175
Cdd:cd14947    21 PGTEFTKTWRLRNTGTVPWPAGTLLRFVGGDPGLLSAPERvpvPSTVPGEEVDVSVELRAPSEPGRYISYWRLVTPDGLP 100

                          90
                  ....*....|..
gi 1845980918 176 FGESIWVIIRVR 187
Cdd:cd14947   101 FGDRLWVDITVE 112
N_BRCA1_IG pfam16158
Ig-like domain from next to BRCA1 gene; Domain present between positions 365-485 in the human ...
 99-186 3.95e-16

Ig-like domain from next to BRCA1 gene; Domain present between positions 365-485 in the human next to BRCA1 gene 1 protein Q14596 (NBR1_HUMAN) Distant homology and fold prediction analysis suggests this domain has an immunoglobulin like fold and is distantly homologous to domains involved in cell adhesion such as CARDB (PF07705). JCSG construct was crystalized confirming the domain boundaries


Pssm-ID: 465035  Cd Length: 98  Bit Score: 71.45  E-value: 3.95e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980918  99 PNSTFFCGWRVVNDGRFRWPDGTRLAFVDGDP-IDYEVWKDTVLDPDQSENIEIRISCPAEMGDFKARFQFVTPQNFFFG 177
Cdd:pfam16158  10 PGTEFTKTWRLRNSGNVAWPAGTSLRFVGGDNmGNVSTVLVPPVAPGEEVDVSVELKAPSRPGRYISYWRLKTPDGTPFG 89


                  ....*....
gi 1845980918 178 ESIWVIIRV 186
Cdd:pfam16158  90 DRLWVDITV 98
UBA_CF106 cd14349
UBA-like domain found in uncharacterized protein C6orf106 and similar proteins; The family ...
 19-61 2.84e-12

UBA-like domain found in uncharacterized protein C6orf106 and similar proteins; The family corresponds to a group of uncharacterized protein C6orf106 and its homologs mainly found in Metazoa. All family members contain a ubiquitin-associated (UBA)-like domain.


Pssm-ID: 270534  Cd Length: 41  Bit Score: 59.54  E-value: 2.84e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1845980918  19 DRENLIHKFEEIISPQmiPHDLAAFYLDLANWNLSTAISVFYD 61
Cdd:cd14349     1 DHEELISQFQSILGAQ--NESEAAFFLEMNNWNLQAAVGAYFD 41
UBA_4 pfam14555
UBA-like domain;
39-65 1.83e-04

UBA-like domain;


Pssm-ID: 464207  Cd Length: 43  Bit Score: 37.82  E-value: 1.83e-04
                          10        20
                  ....*....|....*....|....*..
gi 1845980918  39 DLAAFYLDLANWNLSTAISVFYDQNGD 65
Cdd:pfam14555  16 EVARQYLEAHNWDLEAAVNAFFDDGEA 42
gltB PRK11750
glutamate synthase subunit alpha; Provisional
 35-59 1.14e-03

glutamate synthase subunit alpha; Provisional


Pssm-ID: 236968 [Multi-domain]  Cd Length: 1485  Bit Score: 39.86  E-value: 1.14e-03
                           10        20
                   ....*....|....*....|....*
gi 1845980918   35 MIPHDLAAFYLDLANWNLSTAISVF 59
Cdd:PRK11750   193 MMPADLPRFYLDLADLRLESAICVF 217
 
Name Accession Description Interval E-value
NBR1_like cd14947
Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins; NBR1 has ...
 99-187 2.53e-20

Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins; NBR1 has been characterized as a specific late endosomal protein, which might play a role in receptor (RTK) trafficking. Specifically, NBR1 was shown to inhibit ligand-mediated receptor internalization from the cell surface. The region covered by this domain model may be involved in that function, as the C-terminus (which contains a UBA domain) was shown to be essential but not sufficient by itself. In an earlier yeast two-hybrid study, the region in mouse NBR1 covered by this domain has been shown to interact with CIB (calcium and integrin-binding protein) and FEZ1 (fasciculation and elongation protein zeta-1). Thus, NBR1 may play a role in cellular signalling pathways and possibly in neural development.


Pssm-ID: 271343 [Multi-domain]  Cd Length: 112  Bit Score: 82.72  E-value: 2.53e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980918  99 PNSTFFCGWRVVNDGRFRWPDGTRLAFVDGDPIDYEVWKD---TVLDPDQSENIEIRISCPAEMGDFKARFQFVTPQNFF 175
Cdd:cd14947    21 PGTEFTKTWRLRNTGTVPWPAGTLLRFVGGDPGLLSAPERvpvPSTVPGEEVDVSVELRAPSEPGRYISYWRLVTPDGLP 100

                          90
                  ....*....|..
gi 1845980918 176 FGESIWVIIRVR 187
Cdd:cd14947   101 FGDRLWVDITVE 112
N_BRCA1_IG pfam16158
Ig-like domain from next to BRCA1 gene; Domain present between positions 365-485 in the human ...
 99-186 3.95e-16

Ig-like domain from next to BRCA1 gene; Domain present between positions 365-485 in the human next to BRCA1 gene 1 protein Q14596 (NBR1_HUMAN) Distant homology and fold prediction analysis suggests this domain has an immunoglobulin like fold and is distantly homologous to domains involved in cell adhesion such as CARDB (PF07705). JCSG construct was crystalized confirming the domain boundaries


Pssm-ID: 465035  Cd Length: 98  Bit Score: 71.45  E-value: 3.95e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980918  99 PNSTFFCGWRVVNDGRFRWPDGTRLAFVDGDP-IDYEVWKDTVLDPDQSENIEIRISCPAEMGDFKARFQFVTPQNFFFG 177
Cdd:pfam16158  10 PGTEFTKTWRLRNSGNVAWPAGTSLRFVGGDNmGNVSTVLVPPVAPGEEVDVSVELKAPSRPGRYISYWRLKTPDGTPFG 89


                  ....*....
gi 1845980918 178 ESIWVIIRV 186
Cdd:pfam16158  90 DRLWVDITV 98
UBA_CF106 cd14349
UBA-like domain found in uncharacterized protein C6orf106 and similar proteins; The family ...
 19-61 2.84e-12

UBA-like domain found in uncharacterized protein C6orf106 and similar proteins; The family corresponds to a group of uncharacterized protein C6orf106 and its homologs mainly found in Metazoa. All family members contain a ubiquitin-associated (UBA)-like domain.


Pssm-ID: 270534  Cd Length: 41  Bit Score: 59.54  E-value: 2.84e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1845980918  19 DRENLIHKFEEIISPQmiPHDLAAFYLDLANWNLSTAISVFYD 61
Cdd:cd14349     1 DHEELISQFQSILGAQ--NESEAAFFLEMNNWNLQAAVGAYFD 41
UBA_p47 cd14348
UBA-like domain found in NSFL1 cofactor p47 and similar proteins; p47, also called UBX ...
 38-62 1.10e-04

UBA-like domain found in NSFL1 cofactor p47 and similar proteins; p47, also called UBX domain-containing protein 2C, is a major cofactor of the cytosolic AAA ATPase p97. It is required for the p97-regulated membrane reassembly of the endoplasmic reticulum (ER), the nuclear envelope and the Golgi apparatus. p47, together with p97, forms the p97-p47 complex that plays an important role in regulation of membrane fusion events. p47 contains an N-terminal ubiquitin-associated (UBA)-like domain, a central SEP (named after shp1, eyc and p47) domain, and a ubiquitin-like (UBX) domain. UBA-like domain is responsible for forming a highly stable complex with ubiquitin. SEP domain and UBX domain may involve in p47 trimerization or forms a stable complex with the p97 N-terminal domain.


Pssm-ID: 270533  Cd Length: 40  Bit Score: 38.67  E-value: 1.10e-04
                          10        20
                  ....*....|....*....|....*
gi 1845980918  38 HDLAAFYLDLANWNLSTAISVFYDQ 62
Cdd:cd14348    15 EDRAKFFLESAGWDLEAALSSFFES 39
UBA_4 pfam14555
UBA-like domain;
39-65 1.83e-04

UBA-like domain;


Pssm-ID: 464207  Cd Length: 43  Bit Score: 37.82  E-value: 1.83e-04
                          10        20
                  ....*....|....*....|....*..
gi 1845980918  39 DLAAFYLDLANWNLSTAISVFYDQNGD 65
Cdd:pfam14555  16 EVARQYLEAHNWDLEAAVNAFFDDGEA 42
gltB PRK11750
glutamate synthase subunit alpha; Provisional
 35-59 1.14e-03

glutamate synthase subunit alpha; Provisional


Pssm-ID: 236968 [Multi-domain]  Cd Length: 1485  Bit Score: 39.86  E-value: 1.14e-03
                           10        20
                   ....*....|....*....|....*
gi 1845980918   35 MIPHDLAAFYLDLANWNLSTAISVF 59
Cdd:PRK11750   193 MMPADLPRFYLDLADLRLESAICVF 217
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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