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Conserved domains on  [gi|1833303473|ref|NP_001368870|]
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thrombospondin-2 isoform 4 precursor [Homo sapiens]

Protein Classification

LamG domain-containing protein( domain architecture ID 10641961)

LamG (Laminin G) domain-containing protein may serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules

PubMed:  31092689

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TSPN smart00210
Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of ...
 20-215 2.30e-50

Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of thrombospondin


:

Pssm-ID: 214560  Cd Length: 184  Bit Score: 165.61  E-value: 2.30e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303473   20 HQDKDTTFDLFSISNINRKTIGAKqfrgpdPGVPAYRFVRfdyiPPVNADDLSKITKiMRQKEGFFLTAQLKQDGKSRGT 99
Cdd:smart00210   1 GQDLLQVFDLPSLSFAIRQVVGPE------PGSPAYRLGD----PALVPQPTRDLFP-SGLPEDFSLLTTFRQTPKSRGV 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303473  100 LLALEGPgLSQRQFEIVSNGPADTLDLTY-WIDGTRHVVSLEDVGLADSQWKNVTVQVAGETYSLHVGCDLIDSFALDEP 178
Cdd:smart00210  70 LFAIYDA-QNVRQFGLEVDGRANTLLLRYqGVDGKQHTVSFRNLPLADGQWHKLALSVSGSSATLYVDCNEIDSRPLDRP 148

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 1833303473  179 FYEHLQAEKSRMYVAKGSAREsHFRGLLQNVHLVFEN 215
Cdd:smart00210 149 GQPPIDTDGIEVRGAQAADRK-PFQGDLQQLKIVCDP 184
 
Name Accession Description Interval E-value
TSPN smart00210
Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of ...
 20-215 2.30e-50

Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of thrombospondin


Pssm-ID: 214560  Cd Length: 184  Bit Score: 165.61  E-value: 2.30e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303473   20 HQDKDTTFDLFSISNINRKTIGAKqfrgpdPGVPAYRFVRfdyiPPVNADDLSKITKiMRQKEGFFLTAQLKQDGKSRGT 99
Cdd:smart00210   1 GQDLLQVFDLPSLSFAIRQVVGPE------PGSPAYRLGD----PALVPQPTRDLFP-SGLPEDFSLLTTFRQTPKSRGV 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303473  100 LLALEGPgLSQRQFEIVSNGPADTLDLTY-WIDGTRHVVSLEDVGLADSQWKNVTVQVAGETYSLHVGCDLIDSFALDEP 178
Cdd:smart00210  70 LFAIYDA-QNVRQFGLEVDGRANTLLLRYqGVDGKQHTVSFRNLPLADGQWHKLALSVSGSSATLYVDCNEIDSRPLDRP 148

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 1833303473  179 FYEHLQAEKSRMYVAKGSAREsHFRGLLQNVHLVFEN 215
Cdd:smart00210 149 GQPPIDTDGIEVRGAQAADRK-PFQGDLQQLKIVCDP 184
 
Name Accession Description Interval E-value
TSPN smart00210
Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of ...
 20-215 2.30e-50

Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of thrombospondin


Pssm-ID: 214560  Cd Length: 184  Bit Score: 165.61  E-value: 2.30e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303473   20 HQDKDTTFDLFSISNINRKTIGAKqfrgpdPGVPAYRFVRfdyiPPVNADDLSKITKiMRQKEGFFLTAQLKQDGKSRGT 99
Cdd:smart00210   1 GQDLLQVFDLPSLSFAIRQVVGPE------PGSPAYRLGD----PALVPQPTRDLFP-SGLPEDFSLLTTFRQTPKSRGV 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303473  100 LLALEGPgLSQRQFEIVSNGPADTLDLTY-WIDGTRHVVSLEDVGLADSQWKNVTVQVAGETYSLHVGCDLIDSFALDEP 178
Cdd:smart00210  70 LFAIYDA-QNVRQFGLEVDGRANTLLLRYqGVDGKQHTVSFRNLPLADGQWHKLALSVSGSSATLYVDCNEIDSRPLDRP 148

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 1833303473  179 FYEHLQAEKSRMYVAKGSAREsHFRGLLQNVHLVFEN 215
Cdd:smart00210 149 GQPPIDTDGIEVRGAQAADRK-PFQGDLQQLKIVCDP 184
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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