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Conserved domains on  [gi|1831519550|ref|NP_001368489|]
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DUF4440 domain-containing protein [Caenorhabditis elegans]

Protein Classification

YybH family protein( domain architecture ID 10008488)

YybH family protein similar to ketosteroid isomerase homolog YybH

CATH:  3.10.450.50
SCOP:  3000472

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YybH COG4319
Ketosteroid isomerase homolog YybH [General function prediction only];
6-118 1.83e-19

Ketosteroid isomerase homolog YybH [General function prediction only];


:

Pssm-ID: 443460 [Multi-domain]  Cd Length: 131  Bit Score: 77.49  E-value: 1.83e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831519550   6 QEVKGRQQDFMKAFNAGDAAGAASVYDPDGYFMPNGRNPVKGRSGIEAYFKEDMADGVQTAQIITE-EVNGGGDWAFERG 84
Cdd:COG4319     9 AAIRALLAAFAEAFNAGDADALAALYAEDAVFFDPGGPPVRGREAIRAAWAAAFAAGPRVTFEVEDvRVLVSGDVAVVTG 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1831519550  85 SYHL-----DGTKGRESGAYLQIWKKVE-GVWLIHNDCFN 118
Cdd:COG4319    89 RWRLtgtdpDGEPVELAGRYTLVFRKQAdGRWKIVHDHAS 128
 
Name Accession Description Interval E-value
YybH COG4319
Ketosteroid isomerase homolog YybH [General function prediction only];
6-118 1.83e-19

Ketosteroid isomerase homolog YybH [General function prediction only];


Pssm-ID: 443460 [Multi-domain]  Cd Length: 131  Bit Score: 77.49  E-value: 1.83e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831519550   6 QEVKGRQQDFMKAFNAGDAAGAASVYDPDGYFMPNGRNPVKGRSGIEAYFKEDMADGVQTAQIITE-EVNGGGDWAFERG 84
Cdd:COG4319     9 AAIRALLAAFAEAFNAGDADALAALYAEDAVFFDPGGPPVRGREAIRAAWAAAFAAGPRVTFEVEDvRVLVSGDVAVVTG 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1831519550  85 SYHL-----DGTKGRESGAYLQIWKKVE-GVWLIHNDCFN 118
Cdd:COG4319    89 RWRLtgtdpDGEPVELAGRYTLVFRKQAdGRWKIVHDHAS 128
DUF4440 pfam14534
Domain of unknown function (DUF4440);
13-112 3.06e-13

Domain of unknown function (DUF4440);


Pssm-ID: 434023 [Multi-domain]  Cd Length: 107  Bit Score: 60.87  E-value: 3.06e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831519550  13 QDFMKAFNAGDAAGAASVYDPDGYFMPNGRNPVKGRSGIEAYFKEDMADgvQTAQIITEEVNGGGDWAFERGSYHLDGTK 92
Cdd:pfam14534   6 EALLEALVAGDPAALAALLAPDFVLVGPSGPVLDKDEILEALASGGLDY--SSIELEDEKVRVLGDTAVVRGRVTVTGRG 83

                          90       100
                  ....*....|....*....|....
gi 1831519550  93 GRES----GAYLQIWKKVEGVWLI 112
Cdd:pfam14534  84 DGEPvtvrGRFTSVWKKEGGGWKI 107
TIGR02246 TIGR02246
conserved hypothetical protein; This family consists of uncharacterized proteins found in a ...
 13-115 7.27e-08

conserved hypothetical protein; This family consists of uncharacterized proteins found in a number of genera and species, including Streptomyces, Xanthomonas, Oceanobacillus iheyensis, Caulobacter crescentus CB15, and Xylella fastidiosa. The function is unknown.


Pssm-ID: 274053  Cd Length: 128  Bit Score: 47.37  E-value: 7.27e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831519550  13 QDFMKAFNAGDAAGAASVYDPDGYFMPNGRNPVKGRSGIEAY----FKEDMADGVQTAQIITEEVNGGG---DWAfeRGS 85
Cdd:TIGR02246  11 ARWEAAWAAGDAEAFADLFAPDGVFVTVPGQVRKGREAIRAAheafFAGPYKGTRVTGDVIEVRFLGPDlaiVHT--IQT 88

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1831519550  86 YHLDGtKGRESG----AYLQIWKKVEGVWLIHND 115
Cdd:TIGR02246  89 ITAPG-KGRARPdaavRLTFVAVKRDGRWRLAAD 121
ketosteroid_isomerase cd00781
ketosteroid isomerase: Many biological reactions proceed by enzymatic cleavage of a C-H bond ...
 6-71 2.12e-07

ketosteroid isomerase: Many biological reactions proceed by enzymatic cleavage of a C-H bond adjacent to carbonyl or a carboxyl group, leading to an enol or a enolate intermediate that is subsequently re-protonated at the same or an adjacent carbon. Ketosteroid isomerases are important members of this class of enzymes which are the most proficient of all enzymes known and have served as a paradigm for enzymatic enolizations since its discovery in 1954. This CD includes members of this class that calalyze the isomerization of various beta,gamma-unsaturated isomers at nearly a diffusion-controlled rate. These enzymes are widely distributed in bacteria.


Pssm-ID: 238404  Cd Length: 122  Bit Score: 46.26  E-value: 2.12e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1831519550   6 QEVKGRQQDFMKAFNAGDAAGAASVYDPDGYFM-PNGRNPVKGRSGIEAYFkedmADGVQTAQIITE 71
Cdd:cd00781     3 QEMKAAVQRYVEAVNAGDPEGIVALFADDATVEdPVGSPPRSGRAAIAAFY----AQSLGGAKRLEL 65
 
Name Accession Description Interval E-value
YybH COG4319
Ketosteroid isomerase homolog YybH [General function prediction only];
6-118 1.83e-19

Ketosteroid isomerase homolog YybH [General function prediction only];


Pssm-ID: 443460 [Multi-domain]  Cd Length: 131  Bit Score: 77.49  E-value: 1.83e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831519550   6 QEVKGRQQDFMKAFNAGDAAGAASVYDPDGYFMPNGRNPVKGRSGIEAYFKEDMADGVQTAQIITE-EVNGGGDWAFERG 84
Cdd:COG4319     9 AAIRALLAAFAEAFNAGDADALAALYAEDAVFFDPGGPPVRGREAIRAAWAAAFAAGPRVTFEVEDvRVLVSGDVAVVTG 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1831519550  85 SYHL-----DGTKGRESGAYLQIWKKVE-GVWLIHNDCFN 118
Cdd:COG4319    89 RWRLtgtdpDGEPVELAGRYTLVFRKQAdGRWKIVHDHAS 128
DUF4440 pfam14534
Domain of unknown function (DUF4440);
13-112 3.06e-13

Domain of unknown function (DUF4440);


Pssm-ID: 434023 [Multi-domain]  Cd Length: 107  Bit Score: 60.87  E-value: 3.06e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831519550  13 QDFMKAFNAGDAAGAASVYDPDGYFMPNGRNPVKGRSGIEAYFKEDMADgvQTAQIITEEVNGGGDWAFERGSYHLDGTK 92
Cdd:pfam14534   6 EALLEALVAGDPAALAALLAPDFVLVGPSGPVLDKDEILEALASGGLDY--SSIELEDEKVRVLGDTAVVRGRVTVTGRG 83

                          90       100
                  ....*....|....*....|....
gi 1831519550  93 GRES----GAYLQIWKKVEGVWLI 112
Cdd:pfam14534  84 DGEPvtvrGRFTSVWKKEGGGWKI 107
TIGR02246 TIGR02246
conserved hypothetical protein; This family consists of uncharacterized proteins found in a ...
 13-115 7.27e-08

conserved hypothetical protein; This family consists of uncharacterized proteins found in a number of genera and species, including Streptomyces, Xanthomonas, Oceanobacillus iheyensis, Caulobacter crescentus CB15, and Xylella fastidiosa. The function is unknown.


Pssm-ID: 274053  Cd Length: 128  Bit Score: 47.37  E-value: 7.27e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831519550  13 QDFMKAFNAGDAAGAASVYDPDGYFMPNGRNPVKGRSGIEAY----FKEDMADGVQTAQIITEEVNGGG---DWAfeRGS 85
Cdd:TIGR02246  11 ARWEAAWAAGDAEAFADLFAPDGVFVTVPGQVRKGREAIRAAheafFAGPYKGTRVTGDVIEVRFLGPDlaiVHT--IQT 88

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1831519550  86 YHLDGtKGRESG----AYLQIWKKVEGVWLIHND 115
Cdd:TIGR02246  89 ITAPG-KGRARPdaavRLTFVAVKRDGRWRLAAD 121
ketosteroid_isomerase cd00781
ketosteroid isomerase: Many biological reactions proceed by enzymatic cleavage of a C-H bond ...
 6-71 2.12e-07

ketosteroid isomerase: Many biological reactions proceed by enzymatic cleavage of a C-H bond adjacent to carbonyl or a carboxyl group, leading to an enol or a enolate intermediate that is subsequently re-protonated at the same or an adjacent carbon. Ketosteroid isomerases are important members of this class of enzymes which are the most proficient of all enzymes known and have served as a paradigm for enzymatic enolizations since its discovery in 1954. This CD includes members of this class that calalyze the isomerization of various beta,gamma-unsaturated isomers at nearly a diffusion-controlled rate. These enzymes are widely distributed in bacteria.


Pssm-ID: 238404  Cd Length: 122  Bit Score: 46.26  E-value: 2.12e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1831519550   6 QEVKGRQQDFMKAFNAGDAAGAASVYDPDGYFM-PNGRNPVKGRSGIEAYFkedmADGVQTAQIITE 71
Cdd:cd00781     3 QEMKAAVQRYVEAVNAGDPEGIVALFADDATVEdPVGSPPRSGRAAIAAFY----AQSLGGAKRLEL 65
SnoaL_2 pfam12680
SnoaL-like domain; This family contains a large number of proteins that share the SnoaL fold.
 13-108 5.29e-07

SnoaL-like domain; This family contains a large number of proteins that share the SnoaL fold.


Pssm-ID: 432716 [Multi-domain]  Cd Length: 100  Bit Score: 44.58  E-value: 5.29e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831519550  13 QDFMKAFNAGDAAGAASVYDPDGYFMPNGrNPVKGRSGIEAYFkEDMADGVQTAQIITEEVNGGGDWAFERG--SYHLDG 90
Cdd:pfam12680   2 RRFYEALNAGDLDALAALFAPDAVFHDPG-GPLRGRDAIRAFF-AALFAAFPDLRFEIHDVIADGDRVAVRWtvTGTIPP 79

                          90
                  ....*....|....*...
gi 1831519550  91 TKGRESGAYLQIWKKVEG 108
Cdd:pfam12680  80 TGRGVRVRGVDVFRFRDG 97
YesE COG3631
Ketosteroid isomerase-related protein [General function prediction only];
13-87 6.45e-07

Ketosteroid isomerase-related protein [General function prediction only];


Pssm-ID: 442849  Cd Length: 126  Bit Score: 44.92  E-value: 6.45e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1831519550  13 QDFMKAFNAGDAAGAASVYDPDGYF---MPNGRNPVKGRSGIEAYFkEDMADGVQTAQIITEEVNGGGDWAFERGSYH 87
Cdd:COG3631     7 RRFYAAFNAGDVDALLALLAEDVVWedpGGPGAGTYRGKEAVRAFF-ARLAAAFEDLRFEVRRVVADGDRVVVEGTVR 83
NTF2_like cd00531
Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 ...
 13-117 3.43e-06

Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of divergent evolution wherein the proteins have many common structural details but diverge greatly in their function. For example, nuclear transport factor 2 (NTF2) mediates the nuclear import of RanGDP and binds to both RanGDP and FxFG repeat-containing nucleoporins while Ketosteroid isomerases catalyze the isomerization of delta-5-3-ketosteroid to delta-4-3-ketosteroid, by intramolecular transfer of the C4-beta proton to the C6-beta position. While the function of the beta sub-unit of the Ring hydroxylating dioxygenases is not known, Scytalone Dehydratases catalyzes two reactions in the biosynthetic pathway that produces fungal melanin. Members of the NTF2-like superfamily are widely distributed among bacteria, archaea and eukaryotes.


Pssm-ID: 238296 [Multi-domain]  Cd Length: 124  Bit Score: 42.89  E-value: 3.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831519550  13 QDFMKAFNAGDAAGAASVYDPDGYFMPNGRN----PVKGRSGIEAYFKEDMADGVQTAQIITE-EVNGGGDWAFERGSY- 86
Cdd:cd00531     6 YRYARLLDAGDREWLALLYADDAYFEPPGGDgliyPDDGREAIEDRVRRLPFGPSRTRHLVSNvDVQPGDDGEGVVVSVf 85

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1831519550  87 -----HLDGTKGRESGAYLQIWKKVEGVWLIHNDCF 117
Cdd:cd00531    86 gvlrtRGDGEQDVFAGGQTFVLRPQGGGGKIANRRF 121
CaMKIID COG4875
Protein kinase association domain CaMKII_AD, NTF2-like superfamily [Posttranslational ...
 18-112 4.49e-05

Protein kinase association domain CaMKII_AD, NTF2-like superfamily [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443903  Cd Length: 156  Bit Score: 40.38  E-value: 4.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831519550  18 AFNAGDAAGAASVYDPDGYFMPNGRN-PVKGRSGIEAYFkEDMADGVQTAQIITEEVNGGGDWAFERGSY--HL--DGTK 92
Cdd:COG4875    48 ALQTGDADKVLALYAPDAVLLPTVSNkVRTTRAEIRDYF-EHFLAKKPQGVIDERTIKIGCNTAVDSGTYtfTFtkDGST 126

                          90       100
                  ....*....|....*....|
gi 1831519550  93 GRESGAYLQIWKKVEGVWLI 112
Cdd:COG4875   127 LTVPARYTFTYEKQGGQWLI 146
SnoaL_4 pfam13577
SnoaL-like domain; This family contains a large number of proteins that share the SnoaL fold.
 15-113 1.03e-03

SnoaL-like domain; This family contains a large number of proteins that share the SnoaL fold.


Pssm-ID: 433323 [Multi-domain]  Cd Length: 125  Bit Score: 36.16  E-value: 1.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831519550  15 FMKAFNAGDAAGAASVYDPDGYFMPNGRNPVKGRSGIEAYFKEDMADGVQTAQIITE---EVNGG---GDWAFERGSYHL 88
Cdd:pfam13577  16 YGRALDTGDWDELAALFTEDAVFDYGGLGVLEGRDAIVAGLRAALDGFLLTQHLLGNpviTVDGDtatGRAYLLATHVGP 95

                          90       100
                  ....*....|....*....|....*..
gi 1831519550  89 DGTKGR--ESGAYLQIWKKVEGVWLIH 113
Cdd:pfam13577  96 GDGGPEvlRGGRYEDEYVRTDGGWRIS 122
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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