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Conserved domains on  [gi|1831513693|ref|NP_001368461|]
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UAA transporter [Caenorhabditis elegans]

Protein Classification

nucleotide-sugar transporter family protein( domain architecture ID 706892)

nucleotide-sugar transporter family protein may mediate the transport of nucleotides or sugars or their derivatives; belongs to the drug/metabolite transporter (DMT) superfamily

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UAA super family cl26745
UAA transporter family; This family includes transporters with a specificity for ...
 1-211 6.63e-44

UAA transporter family; This family includes transporters with a specificity for UDP-N-acetylglucosamine.


The actual alignment was detected with superfamily member pfam08449:

Pssm-ID: 462479 [Multi-domain]  Cd Length: 307  Bit Score: 148.98  E-value: 6.63e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831513693   1 MTMGWIIRNYQYSLKQISAVVVVTAGIVIFTLASyepGAQNIRSGIDSNSWlipippFVVGLALLSFALILSAYLGLYQE 80
Cdd:pfam08449 109 MIMGILILGKRYSKLQYLSAFLVTLGIIIFTLFS---AKDKVADSVVSPNF------FLIGIAMLSGALLLDAFLGNYQE 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831513693  81 TFYQKHGKHNEEMMFYVHFLSIPLFAFVGDDMVPAFHAAYSTPSFviagLDTVVPSAWVYIFAICLFQFACTKGVYMLSA 160
Cdd:pfam08449 180 KTYKKYGKHSKEMLFYSHLLSLPFFLLLQGDLFSAVQFCSQSPDK----AVLSLPSMLFYLLLNVLTQYVCIRGVFILIS 255

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1831513693 161 VTTSLNVTMVLTLRKFFSLLISFIVFENVFNMFHIIGAAFVFIGTILFSVS 211
Cdd:pfam08449 256 EFGALTVTLVTTLRKFVSLLLSILLFGNPFTLQHWVGTLLVFLGTFLYSYS 306
 
Name Accession Description Interval E-value
UAA pfam08449
UAA transporter family; This family includes transporters with a specificity for ...
 1-211 6.63e-44

UAA transporter family; This family includes transporters with a specificity for UDP-N-acetylglucosamine.


Pssm-ID: 462479 [Multi-domain]  Cd Length: 307  Bit Score: 148.98  E-value: 6.63e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831513693   1 MTMGWIIRNYQYSLKQISAVVVVTAGIVIFTLASyepGAQNIRSGIDSNSWlipippFVVGLALLSFALILSAYLGLYQE 80
Cdd:pfam08449 109 MIMGILILGKRYSKLQYLSAFLVTLGIIIFTLFS---AKDKVADSVVSPNF------FLIGIAMLSGALLLDAFLGNYQE 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831513693  81 TFYQKHGKHNEEMMFYVHFLSIPLFAFVGDDMVPAFHAAYSTPSFviagLDTVVPSAWVYIFAICLFQFACTKGVYMLSA 160
Cdd:pfam08449 180 KTYKKYGKHSKEMLFYSHLLSLPFFLLLQGDLFSAVQFCSQSPDK----AVLSLPSMLFYLLLNVLTQYVCIRGVFILIS 255

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1831513693 161 VTTSLNVTMVLTLRKFFSLLISFIVFENVFNMFHIIGAAFVFIGTILFSVS 211
Cdd:pfam08449 256 EFGALTVTLVTTLRKFVSLLLSILLFGNPFTLQHWVGTLLVFLGTFLYSYS 306
nst TIGR00803
UDP-galactose transporter; The 10-12 TMS Nucleotide Sugar Transporters (TC 2.A.7.10) ...
 57-208 1.51e-07

UDP-galactose transporter; The 10-12 TMS Nucleotide Sugar Transporters (TC 2.A.7.10)Nucleotide-sugar transporters (NSTs) are found in the Golgi apparatus and the endoplasmic reticulum of eukaryotic cells. Members of the family have been sequenced from yeast, protozoans and animals. Animals such as C. elegans possess many of these transporters. Humans have at least two closely related isoforms of the UDP-galactose:UMP exchange transporter.NSTs generally appear to function by antiport mechanisms, exchanging a nucleotide-sugar for a nucleotide. Thus, CMP-sialic acid is exchanged for CMP; GDP-mannose is preferentially exchanged for GMP, and UDP-galactose and UDP-N-acetylglucosamine are exchanged for UMP (or possibly UDP). Other nucleotide sugars (e.g., GDP-fucose, UDP-xylose, UDP-glucose, UDP-N-acetylgalactosamine, etc.) may also be transported in exchange for various nucleotides, but their transporters have not been molecularly characterized. Each compound appears to be translocated by its own transport protein. Transport allows the compound, synthesized in the cytoplasm, to be exported to the lumen of the Golgi apparatus or the endoplasmic reticulum where it is used for the synthesis of glycoproteins and glycolipids.


Pssm-ID: 129885  Cd Length: 222  Bit Score: 50.05  E-value: 1.51e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831513693  57 PFVVGLALLSFALILSAYLGLYQETFYQKHGKHNEEMMFYVHFLSIPLFAFVgddmVPAFHAAYSTPSFVIA-GLDTVVP 135
Cdd:TIGR00803  77 TLMFGNPVVGLSAVLSALLSSGFAGVYFEKILKDGDTMFWSRNLQLPLFGLF----STFSVLLWSDGTLISNfGFFIGYP 152

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1831513693 136 SAWVYIFAICLFQFACTKGVYMLSAVTTslnVTMVLTLRKFFSLLISFIVFENVFNMFHIIGAAFVFIGTILF 208
Cdd:TIGR00803 153 TAVWIVGLLNVGGGLCIGGVVRYADNTT---KSFVTALSIILSTLASVRLFDAKISSTFYLGAILVFLATFLY 222
 
Name Accession Description Interval E-value
UAA pfam08449
UAA transporter family; This family includes transporters with a specificity for ...
 1-211 6.63e-44

UAA transporter family; This family includes transporters with a specificity for UDP-N-acetylglucosamine.


Pssm-ID: 462479 [Multi-domain]  Cd Length: 307  Bit Score: 148.98  E-value: 6.63e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831513693   1 MTMGWIIRNYQYSLKQISAVVVVTAGIVIFTLASyepGAQNIRSGIDSNSWlipippFVVGLALLSFALILSAYLGLYQE 80
Cdd:pfam08449 109 MIMGILILGKRYSKLQYLSAFLVTLGIIIFTLFS---AKDKVADSVVSPNF------FLIGIAMLSGALLLDAFLGNYQE 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831513693  81 TFYQKHGKHNEEMMFYVHFLSIPLFAFVGDDMVPAFHAAYSTPSFviagLDTVVPSAWVYIFAICLFQFACTKGVYMLSA 160
Cdd:pfam08449 180 KTYKKYGKHSKEMLFYSHLLSLPFFLLLQGDLFSAVQFCSQSPDK----AVLSLPSMLFYLLLNVLTQYVCIRGVFILIS 255

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1831513693 161 VTTSLNVTMVLTLRKFFSLLISFIVFENVFNMFHIIGAAFVFIGTILFSVS 211
Cdd:pfam08449 256 EFGALTVTLVTTLRKFVSLLLSILLFGNPFTLQHWVGTLLVFLGTFLYSYS 306
nst TIGR00803
UDP-galactose transporter; The 10-12 TMS Nucleotide Sugar Transporters (TC 2.A.7.10) ...
 57-208 1.51e-07

UDP-galactose transporter; The 10-12 TMS Nucleotide Sugar Transporters (TC 2.A.7.10)Nucleotide-sugar transporters (NSTs) are found in the Golgi apparatus and the endoplasmic reticulum of eukaryotic cells. Members of the family have been sequenced from yeast, protozoans and animals. Animals such as C. elegans possess many of these transporters. Humans have at least two closely related isoforms of the UDP-galactose:UMP exchange transporter.NSTs generally appear to function by antiport mechanisms, exchanging a nucleotide-sugar for a nucleotide. Thus, CMP-sialic acid is exchanged for CMP; GDP-mannose is preferentially exchanged for GMP, and UDP-galactose and UDP-N-acetylglucosamine are exchanged for UMP (or possibly UDP). Other nucleotide sugars (e.g., GDP-fucose, UDP-xylose, UDP-glucose, UDP-N-acetylgalactosamine, etc.) may also be transported in exchange for various nucleotides, but their transporters have not been molecularly characterized. Each compound appears to be translocated by its own transport protein. Transport allows the compound, synthesized in the cytoplasm, to be exported to the lumen of the Golgi apparatus or the endoplasmic reticulum where it is used for the synthesis of glycoproteins and glycolipids.


Pssm-ID: 129885  Cd Length: 222  Bit Score: 50.05  E-value: 1.51e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831513693  57 PFVVGLALLSFALILSAYLGLYQETFYQKHGKHNEEMMFYVHFLSIPLFAFVgddmVPAFHAAYSTPSFVIA-GLDTVVP 135
Cdd:TIGR00803  77 TLMFGNPVVGLSAVLSALLSSGFAGVYFEKILKDGDTMFWSRNLQLPLFGLF----STFSVLLWSDGTLISNfGFFIGYP 152

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1831513693 136 SAWVYIFAICLFQFACTKGVYMLSAVTTslnVTMVLTLRKFFSLLISFIVFENVFNMFHIIGAAFVFIGTILF 208
Cdd:TIGR00803 153 TAVWIVGLLNVGGGLCIGGVVRYADNTT---KSFVTALSIILSTLASVRLFDAKISSTFYLGAILVFLATFLY 222
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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