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Conserved domains on  [gi|1831512200|ref|NP_001368249|]
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C2H2-type domain-containing protein [Caenorhabditis elegans]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
40-107 1.90e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 1.90e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831512200  40 QKPFQCRICMRRFSRSDHLTTHVRTHTGEKPYSC--DICGKKFARCDERTRHTKIHKKSGPGKHKMKCGP 107
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPL 100
COG5048 super family cl34881
FOG: Zn-finger [General function prediction only];
1-61 5.66e-04

FOG: Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5048:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.14  E-value: 5.66e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1831512200   1 MKSSKMHLQDRPYKCPRDECDKKFSRSDELTRHIRIHTGQKPFQCRICmRRFSRSDHLTTH 61
Cdd:COG5048   405 SLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSIL-KSFRRDLDLSNH 464
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
40-107 1.90e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 1.90e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831512200  40 QKPFQCRICMRRFSRSDHLTTHVRTHTGEKPYSC--DICGKKFARCDERTRHTKIHKKSGPGKHKMKCGP 107
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPL 100
zf-H2C2_2 pfam13465
Zinc-finger double domain;
57-82 3.49e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 3.49e-04
                          10        20
                  ....*....|....*....|....*.
gi 1831512200  57 HLTTHVRTHTGEKPYSCDICGKKFAR 82
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
1-61 5.66e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.14  E-value: 5.66e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1831512200   1 MKSSKMHLQDRPYKCPRDECDKKFSRSDELTRHIRIHTGQKPFQCRICmRRFSRSDHLTTH 61
Cdd:COG5048   405 SLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSIL-KSFRRDLDLSNH 464
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
40-107 1.90e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 1.90e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831512200  40 QKPFQCRICMRRFSRSDHLTTHVRTHTGEKPYSC--DICGKKFARCDERTRHTKIHKKSGPGKHKMKCGP 107
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPL 100
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
9-79 8.79e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.23  E-value: 8.79e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1831512200   9 QDRPYKCPrdECDKKFSRSDELTRHIRIHTGQKPFQCRICMR--RFSRSDHLTTHVRTHTGEKPYSCDICGKK 79
Cdd:COG5048    30 APRPDSCP--NCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSDLNSKSLPL 100
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 11-80 3.48e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 3.48e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1831512200  11 RPYKCPRDECDKKFSRSDELTRHiRIHTGQKPFQCR----ICMRRFSRSDhltthvrthtgeKPYSCDICGKKF 80
Cdd:COG5189   348 KPYKCPVEGCNKKYKNQNGLKYH-MLHGHQNQKLHEnpspEKMNIFSAKD------------KPYRCEVCDKRY 408
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
13-98 1.83e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 1.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831512200  13 YKCPRDECDKKFSRSDELTRHIR--IHTGQ--KPFQCRI--CMRRFSRSDHLTTHVRTHTGEKPYSC--DICGKKFARCD 84
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                          90
                  ....*....|....
gi 1831512200  85 ERTRHTKIHKKSGP 98
Cdd:COG5048   368 NNEPPQSLQQYKDL 381
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
40-116 5.33e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 5.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831512200  40 QKPFQCRICMRRFSRSDHLTTHVRT--HTGE--KPYSCDI--CGKKFARCDERTRHTKIHKKSGPGKHKMKCGPPWRIQC 113
Cdd:COG5048   287 SLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPL 366


                  ...
gi 1831512200 114 LNN 116
Cdd:COG5048   367 LNN 369
zf-H2C2_2 pfam13465
Zinc-finger double domain;
57-82 3.49e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 3.49e-04
                          10        20
                  ....*....|....*....|....*.
gi 1831512200  57 HLTTHVRTHTGEKPYSCDICGKKFAR 82
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
1-61 5.66e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.14  E-value: 5.66e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1831512200   1 MKSSKMHLQDRPYKCPRDECDKKFSRSDELTRHIRIHTGQKPFQCRICmRRFSRSDHLTTH 61
Cdd:COG5048   405 SLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSIL-KSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
11-55 1.25e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 37.37  E-value: 1.25e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1831512200  11 RPYKCPRDECDKKFSRSDELTRHIRIHTGQKPFQCRICMRRFSRS 55
Cdd:COG5048   320 KPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFS 364
zf-H2C2_2 pfam13465
Zinc-finger double domain;
29-54 1.40e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 1.40e-03
                          10        20
                  ....*....|....*....|....*.
gi 1831512200  29 ELTRHIRIHTGQKPFQCRICMRRFSR 54
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
7-48 2.97e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 36.21  E-value: 2.97e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1831512200   7 HLQDRPYKCPRDECDKKFSRSDELTRHIRIHTGQKPFQCRIC 48
Cdd:COG5048    56 HTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKS 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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