|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
9-437 |
0e+00 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 563.09 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 9 KVMVFVVTFVSYGLYHASRKALSGVKSSIKADWLSNSSG-----------HAPLFTNEADAKHFLGSLDAIFMAAYAAAL 77
Cdd:cd17342 1 HVVVFILTFFSYALLHATRKTFSNVKPSISAEWTPSNSNtsielheetwnANPLFPSQDDAALFLGVLDTIFLFSYAIGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 78 FFWGWLGDRLNPKLVVAAGMVGSAVTLTLFGAIPKWFNFYHAPYYIMTYVAFGLVQACGWPSEIAIMANWFGKGNRGFVM 157
Cdd:cd17342 81 FISGWLGDRLNLRLVLAFGMCSSAITVFLFGVLTEWLHFYNKYLYCILWVLNGLLQSTGWPCVVAIMGNWFGKSSRGFVL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 158 GVWAACQPVGNIFGSIFTAMVLPLGYQYTFVFNSVLIALGAIVVVMAIDSSPneehedgveanrirllrrssssephhnf 237
Cdd:cd17342 161 GLWSACASVGNIIGALLASSVLDYGYEYAFLVTSSLLFAGAIVVFFGLLSSP---------------------------- 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 238 hgepislfkavllPGVLAYCICNACLKLVNYAFFFWLPLYLTDAYHWEESQADQLSIWYDFGGIIGSVLGGYITDKMGKR 317
Cdd:cd17342 213 -------------PGVIPYSLAYACLKLVNYSFFFWLPFYLSNNFHWKESEADQLSIWYDVGGIIGGIVAGYISDRMGSR 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 318 SPLIVAMLVCSIGSLYFYAHVGPHMFWNAVVMTTVGVTVSGPYNLIVGSISIDLGSQPALAGNTQAMSTVSGLLDGTGSA 397
Cdd:cd17342 280 SPVVVVMLLLAIPSLFVYSHSPSDKVLNAFVMTITGFFIGGPANLISSAISADLGRQPQLRGSSEALATVTGIIDGTGSI 359
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 1831518361 398 GSAVGQLLIPIIQDDLGWKAVFYVFMLLNGFAILAILKRC 437
Cdd:cd17342 360 GAAIGQVLVPLIQNRLGWMWVFYFFIIMTILTIVCILPLL 399
|
|
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
9-439 |
3.23e-84 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 264.56 E-value: 3.23e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 9 KVMVFVVTFVSYGLYHASRKALSGVKSSIKADWLSNSS------------GHAPLftNEADAKHFLGSLDAIFMAAYAAA 76
Cdd:cd17344 1 RGFILVLTFLAYACYHLSRKPISIVKSVLHPNCSALIPppnivlnnttwcGWAPF--DGKNGTELLGALDSAFLFAYAIG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 77 LFFWGWLGDRLNPKLVVAAGMVGSAVTLTLFGaIPKWFNFYHAPYYIMTYVAFGLVQACGWPSEIAIMANWFGKGNRGFV 156
Cdd:cd17344 79 MFFSGHIGERLPLRYFLSFGMLLSGLFTALFG-LGYYWNIHSLWYFVVVQILAGLFQSTGWPSVVACVGNWFGKGKRGLI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 157 MGVWAACQPVGNIFGSIFTAMVLPLGYQYTFVFNSVLIALGAIVVVMAIDSSPneehedgveanrirllrrssssephhn 236
Cdd:cd17344 158 MGIWNSHTSVGNILGSLIAGIFVSSAWGLSFIVPGIIIAAMGVLVFLFLVEHP--------------------------- 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 237 fhgepislfkavllPGVLAYCICNACLKLVNYAFFFWLPLYLTDAYHWEESQADQLSIWYDFGGIIGSVLGGYITDKMGK 316
Cdd:cd17344 211 --------------PGVIEFSLCLFFAKLVSYTFLYWLPLYISNTAILSAKKAGDLSTLFDVGGIVGGILAGYISDYTGG 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 317 RSPLIVAMLVCSIGSLYFYAHVGP-HMFWNAVVMTTVGVTVSGPYNLIVGSISIDLGSQPALAGNTQAMSTVSGLLDGTG 395
Cdd:cd17344 277 RATTCAAMLILAAPMLFIYNYFGQvSMTTNIVLLIVCGLLVNGPYALITTAVSADLGTHKSLKGNARALATVTAIIDGTG 356
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 1831518361 396 SAGSAVGQLLIPIIQDDlGWKAVFYVFMLLNGFAILaILKRCII 439
Cdd:cd17344 357 SIGAALGPLLAGLISSR-GWNNVFYMLIAADVCAGL-LLTRLVY 398
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
9-434 |
6.86e-56 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 189.79 E-value: 6.86e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 9 KVMVFVVTFVSYGLYHASRKALSGVKSSIKADwlsnssghAPLftneadAKHFLGSLDAIFMAAYAAALFFWGWLGDRLN 88
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEE--------IGL------SKDDLGIIGSAFLIAYAVGKFISGFLSDRSN 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 89 PKLVVAAGMVGSAVTLTLFGAipkwfnFYHAPYYIMTYVAFGLVQACGWPSEIAIMANWFGKGNRGFVMGVWAACQPVGN 168
Cdd:cd17312 67 IRRFMSAGLLLSALANIFMGF------STSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGG 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 169 IFGSIFTAMVL-PLGYQYTFVFNSVLIALGAIVVVMAIDSSPneehedgveanrirllrrssssephhnfhgepislfka 247
Cdd:cd17312 141 ILAPILAASLAsYYGWRAAFLVPGIVGLVVAIILFFFLRDSP-------------------------------------- 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 248 vllPGVLAYCICNACLKLVNYAFFFWLPLYLTDAYHWEESQADQLSIWYDFGGIIGSVLGGYITDKM--GKRSPLIVAML 325
Cdd:cd17312 183 ---PYVWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLfgGRRAPIAVIYM 259
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 326 VCSIGSLYFYAHVGPHMFWNAVVMTTVGVTVSGPYNLIVGSISIDLGSQPALagntqamSTVSGLLDGTGSAGSAVGQLL 405
Cdd:cd17312 260 LLMTLSLALFWFFPHNKLLSIVLLFLIGFFVGGPINLIGGAAAQDIGRKEAA-------GTATGFVGLFGYLGASLAGLP 332
|
410 420
....*....|....*....|....*....
gi 1831518361 406 IPIIQDDLGWKAVFYVFMLLNGFAILAIL 434
Cdd:cd17312 333 LGYIIDHYGWSTVFYFLISAALLSVLLLL 361
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
3-434 |
7.74e-37 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 138.85 E-value: 7.74e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 3 QTMSSRKVMVFVVTFVSYGLYHASRKALSGVKSSIKADW-LSNSSghaplftneadakhfLGSLDAIFMAAYAAALFFWG 81
Cdd:COG2271 2 RAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLgLSAAQ---------------LGLLASAFFLGYALGQIPAG 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 82 WLGDRLNPKLVVAAGMVGSAVTLTLFGAIPKWFNFYhapyyiMTYVAFGLVQACGWPSEIAIMANWFGKGNRGFVMGVWA 161
Cdd:COG2271 67 LLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLL------LLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFN 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 162 ACQPVGNIFGSIFTAMVLP-LGYQYTFVFNSVLIALGAIVVVMAIdsspneehedgveanrirllrrssssephhnfhge 240
Cdd:COG2271 141 AGGPLGGALAPPLLGWLLAaFGWRAAFLILGLPGLLLALLRFWLL----------------------------------- 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 241 pislfkavllpgvlayCICNACLKLVNYAFFFWLPLYLTDAYHWEESQADQLSIWYDFGGIIGSVLGGYITDKMGKR-SP 319
Cdd:COG2271 186 ----------------ALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrKL 249
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 320 LIVAMLVCSIGSLYFYAHVGPHMFwnavvmttvGVTVSGPYNLIVGSISIDLGSQPALAGNTQAMSTVSGLLDGTGSAGS 399
Cdd:COG2271 250 VLAIGLLLAALALLLLALLPSPAL---------AIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGG 320
|
410 420 430
....*....|....*....|....*....|....*
gi 1831518361 400 AVGQLLIPIIQDDLGWKAVFYVFMLLNGFAILAIL 434
Cdd:COG2271 321 ALGPLLVGYLLDATGYQAAFLLLAALALLAALLAL 355
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
78-434 |
3.80e-28 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 115.42 E-value: 3.80e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 78 FFWGWLGDRLNPKLVVAAGMVGSAVTLTLFGAIPkwfnFYHAPYYIMT--YVAFGLVQACGWPSEIAIMANWFGKGNRGF 155
Cdd:cd17345 56 FVMGNLSDRSNPKRFLAIGLILSAIINILIGFVP----SATSSVGLMFilLFLNGWFQGMGWPPSGRTMVHWFSKKERGT 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 156 VMGVWAACQPVGN-IFGSIFTAMVLPLG---YQYTFVFNSVLIALGAIVVVMAIDSSPNEEHEDGVEANRIRLLRRSSSS 231
Cdd:cd17345 132 WTSIWNISHNVGGgLVGPLAGLGLAIFGdgwWRGAFIFPAIIAIIVAVIVLFLGKDTPESEGLPPIEEYKGDYPEEADGE 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 232 EPHHNFHGEPIsLFKAVLL-PGVLAYCICNACLKLVNYAFFFWLPLYLTDAYHWEESQADQLSIWYDFGGIIGSVLGGYI 310
Cdd:cd17345 212 EEEQELSAWEI-FVKYVLKnKLLWYIAIANVFVYLVRYGILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWL 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 311 TDKM--GKRSPLIVAMLVCSIGSLYFYAHVgPHMFWNAVVMTTVGVTVSGPyNLIVGSISIDLgSQPALAGNTQAMSTVS 388
Cdd:cd17345 291 SDKLfkGRRAPTGIIFMILVIVALIVYWLA-PNVLVDLIALIALGFLIYGP-VMLIGLQALEL-VPKKAAGTAAGLTGLF 367
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1831518361 389 GLLdgtgsAGSAVGQLLIPIIQDDLGWKAVFYVFMLLNGFAILAIL 434
Cdd:cd17345 368 GYL-----GGSVLATALIGIIVDHFGWNGGFIVLLASCILAIIFLA 408
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
59-402 |
2.02e-24 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 103.65 E-value: 2.02e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 59 KHFLGSLDAIFMAAYAAALFFWGWLGDRLNPKLVVAAGMVGSAVTLTLFGAIPKWFNFyhapyyIMTYVAFGLVQACGWP 138
Cdd:pfam07690 31 PTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLL------LVLRVLQGLGAGALFP 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 139 SEIAIMANWFGKGNRGFVMGVWAACQPVGNIFGSIFTAMVLP-LGYQYTFVFNSVLIALGAIVVVMAIDSSPNEEHEDGV 217
Cdd:pfam07690 105 AALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASlFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAE 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 218 EANRIRllrrssssephhnfhgepISLFKAVLLPGVLAYCICNACLKLVNYAFFFWLPLYLTDaYHWEESQADQLSIWYD 297
Cdd:pfam07690 185 EARLSL------------------IVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEV-LGLSALLAGLLLGLGG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 298 FGGIIGSVLGGYITDKMGKRSPLIVAMLVCSIGSLYFyahvgphMFWNAVVMTTVGVTVSGPYNLIVGSISIDLGSQPAL 377
Cdd:pfam07690 246 LLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGL-------LLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSD 318
|
330 340
....*....|....*....|....*
gi 1831518361 378 AGNTQAMSTVSGLLDGTGSAGSAVG 402
Cdd:pfam07690 319 LAPKEERGTASGLYNTAGSLGGALG 343
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
67-344 |
5.83e-22 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 96.58 E-value: 5.83e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 67 AIFMAAYAAALFFWGWLGDRLNPKLVVAAGMVGSAVTLTLFGAIPkwfnfyHAPYYIMTYVAFGLVQACGWPSEIAIMAN 146
Cdd:COG2814 52 TAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAP------SLWLLLAARFLQGLGAGALFPAALALIAD 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 147 WFGKGNRGFVMGVWAACQPVGNIFGSIFTAMVLP-LGYQYTFVFNSVLIALGAIVVVMAIDSSPNEEHEDGVEanrirll 225
Cdd:COG2814 126 LVPPERRGRALGLLGAGLGLGPALGPLLGGLLADlFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRG------- 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 226 rrssssephhnfhgepiSLFKAVLLPGVLAYCICNACLKLVNYAFFFWLPLYLTDAYHWEESQADQLSIWYDFGGIIGSV 305
Cdd:COG2814 199 -----------------SLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGAL 261
|
250 260 270
....*....|....*....|....*....|....*....
gi 1831518361 306 LGGYITDKMGKRSPLIVAMLVCSIGSLYFYAHVGPHMFW 344
Cdd:COG2814 262 LAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLL 300
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
80-434 |
2.78e-21 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 94.94 E-value: 2.78e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 80 WGWLGDRLNPKLVVAAGMVGSAVTLTLFGAIPKWFNFYHApyyimtYVAFGLVQACGWPSEIAIMANWFGKGNRGFVMGV 159
Cdd:cd17319 58 GGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVL------RFLLGVAEAGFFPGAIKALAEWFPARERGRATGL 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 160 WAACQPVGNIFGS-IFTAMVLPLGYQYTFVFnsvliaLGAIVVVMAIdsspneehedgveanrirllrrssssephhnfh 238
Cdd:cd17319 132 FNSGAPLGAAIGPpLSGWLLLLFGWRWAFII------EGLLGLLLAV--------------------------------- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 239 gepislFKAVLLPGVLAYCICNACLKLVNYAFFFWLPLYLTDAYHWEESQADQLSIWYDFGGIIGSVLGGYITDKM--GK 316
Cdd:cd17319 173 ------LWWFYLRQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLlrGA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 317 RSPLIVAMLVCSIGSLYFYAHVGPHmfWNAVVMTTVGVTVSGPYNLIVGSISIDLGSQPALAgntqamsTVSGLLDGTGS 396
Cdd:cd17319 247 RRLVIIIGLLLAAVGLLLAYLTTSP--VVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAA-------TAGGLINSGGN 317
|
330 340 350
....*....|....*....|....*....|....*....
gi 1831518361 397 AGSAVGQLLIPIIQDDLG-WKAVFYVFMLLNGFAILAIL 434
Cdd:cd17319 318 LGGFVAPLLIGYLVDATGsYTAAFLFLAAVALLAALLVL 356
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
50-434 |
4.81e-20 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 91.48 E-value: 4.81e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 50 PLFTNEADAKHFL-GSLDAIFMAAYAAALFFWGWLGDRLNPKLVVAAGMVGSAVTLTLFGAIPKWfnfyhaPYYIMTYVA 128
Cdd:cd17325 20 PLYAESLGASVAQiGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSY------WQLLLARFL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 129 FGLVQACGWPSEIAIMANWFGKGNRGFVMGVWAACQPVGNIFGSIF-TAMVLPLGYQYTFVFNSVLIALGAIVVVMAIDS 207
Cdd:cd17325 94 QGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLgGLLADALGYRAPFLVCAALALLALVLALLLLPE 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 208 SPNEEHEDGVEANRIRLLRRSSSSEphhnfhgepislfkavllPGVLAYCICNACLKLVNYAFFFWLPLYLTDAYHWEES 287
Cdd:cd17325 174 PRPPPNKRAVSAARLRSGLRLLLRD------------------RRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 288 QADQLSIWYDFGGIIGSVLGGYITDKMGKRSPLIVAMLVCSIG-SLYFYAHVGPHMFWNAVVMTtvgvtvsgpynLIVGS 366
Cdd:cd17325 236 QIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVAlLLLPLATSFWLLLLLLALLG-----------LGLGL 304
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1831518361 367 ISIDLGSQPALAGNTQAMSTVSGLLDGTGSAGSAVGQLLIPIIQDDLGWKAVFYVFMLLNGFAILAIL 434
Cdd:cd17325 305 VFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFL 372
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
62-434 |
8.63e-20 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 90.71 E-value: 8.63e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 62 LGSLDAIFMAAYAAALFFWGWLGDRLNPKLVVAAGMVGSAVTLTLFGaipkwfnfyHAPYYIMTYVA---FGLVQACGWP 138
Cdd:COG2223 42 LGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLA---------LAVSYWLLLLLgllLGIGGGGSFA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 139 SEIAIMANWFGKGNRGFVMGVWAACQPVGNIFGSIFTAMVL-PLGYQYTFVFNSVLIALGAIVVVMAIDSSPneEHEDGV 217
Cdd:COG2223 113 VGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIaAFGWRNAFLILGILLLVVAVLAWLFLRDPP--AGAAAA 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 218 EANRIRLLRrssssephhnfhgEPISLFKAVLLpgVLAYCICNACLklvnYAFFFWLPLYLTDAYHWEESQADQLSIWYD 297
Cdd:COG2223 191 AKASLRDQL-------------EALRDPRFWLL--SLLYFGTFGSF----IGFSSWLPPYLVDQFGLSAATAGLLAALFA 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 298 FGGIIGSVLGGYITDKMGKRSPLIVAMLVCSIGSLYFYAHVGPhmFWNAVVMTTVGVTVSGPYNlivgsisidlGSQPAL 377
Cdd:COG2223 252 LLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGS--LWLFLVLFLLLGLALGGGN----------GAVFAL 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1831518361 378 AG---NTQAMSTVSGLLDGTGSAGSAVGQLLIPIIQDDLG-WKAVFYVFMLLNGFAILAIL 434
Cdd:COG2223 320 VPdifPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTL 380
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
78-419 |
1.92e-19 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 89.74 E-value: 1.92e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 78 FFWGWLGDRLNPKLVVAAGMVGSAVTLTLFGAIPkwfnfyHAPYYIMTYVAFGLVQACGWPSEIAIMANWFGKGNRGFVM 157
Cdd:TIGR00881 48 FVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFST------SLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWV 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 158 GVWAacqpVGNIFGSIFTAMVLPLGYQYTFVFNSVLIALGAIVVVMA------------------IDSSPNEEHEDGVEA 219
Cdd:TIGR00881 122 SFWN----CSHNVGGGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVSlicflllrdspqscglppAEEMPNEEPDGDAEK 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 220 NRIRLLRRSSssephhnfhgepisLFKAVLLPGVLAY-CICNACLKLVNYAFFFWLPLYLTDAYHWEESQADQLSIWYDF 298
Cdd:TIGR00881 198 KEEELTKKQI--------------FLQYVLLNKVLWYiSLGYVFVYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYEL 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 299 GGIIGSVLGGYITDKM--GKRSPLIVAMLVCSIGSLYFYAH-VGPHMFWNAVVMTTVGVTVSGPYNLIvgsisidlGSQP 375
Cdd:TIGR00881 264 GGLVGTLLAGWLSDKLfnGRRGPLAVFFMALIIVSLLVYWLnPAANPLMDLICLFALGFLVYGPQMLI--------GVIA 335
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1831518361 376 ALAGNTQAMSTVSGLLDGTGSAGSAVGQLLIPIIQDDLGWKAVF 419
Cdd:TIGR00881 336 SELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFGWAGAF 379
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
62-434 |
2.26e-19 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 89.41 E-value: 2.26e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 62 LGSLDAIFMAAYAAALFFWGWLGDRLNPKLVVAAGMVGSAVTLTLFGAIPKWfnfyhaPYYIMTYVAFGLVQACGWPSEI 141
Cdd:cd06174 33 LGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSF------WLLLLGRFLLGLGSGLIDPAVL 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 142 AIMANWFGKGNRGFVMGVWAACQPVGNIFGSIFtamVLPLGYQYTFVFNSVLIALGAIVVVMAIdsspneehedgVEANR 221
Cdd:cd06174 107 ALIADLFPERERGRALGLLQAFGSVGGILGPLL---GGILASSLGFGWRAVFLIAAALALLAAI-----------LLLLV 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 222 IRLLRRSSSSEPHHNFHGEPISLFKAVLL-PGVLAYCICNACLKLVNYAFFFWLPLYLTDAYHWEESQADQLSIWYDFGG 300
Cdd:cd06174 173 VPDPPESARAKNEEASSKSVLKLLKRVLKnPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAG 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 301 IIGSVLGGYITDKMGKRSPLIVAMLVCSIGSLYFYAHVGPHMFWNAVVMTtvgvtvsgpYNLIVGSISIDLGSQPALAGN 380
Cdd:cd06174 253 ALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLL---------LGFGLGGLLPLSFALIAELFP 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1831518361 381 TQAMSTVSGLLDGTGSAGSAVGQLLIPIIQDD-LGWKAVFYVFMLLNGFAILAIL 434
Cdd:cd06174 324 PEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAAtFGLTGAFLVLAVLLLLAAILLL 378
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
78-434 |
1.57e-16 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 81.07 E-value: 1.57e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 78 FFWGWLGDRLNPKLVVAAGMVGSAVTLTLFGAIPkwfnfyHAPYYIMTYVAFGLVQACGWPSEIAIMANWFGKgNRGFVM 157
Cdd:COG2807 71 PLAPRLARRFGLERTLLLALLLLAAGLLLRSLAP------SVALLLAGTALIGAGIAVGNVLLPGLIKRWFPD-RVGLMT 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 158 GVWAACQPVGNIFGSIFTAMVLP-LGYQYTFVFNSVLIALGAIVVVMAIDSSPNEEHEDGVEANRIRLLRRSsssephhn 236
Cdd:COG2807 144 GLYTAAMGLGAALAAGLTVPLAAaLGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAASLRSLWRSP-------- 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 237 fhgepislfKAVLLpgVLAYCICNaclkLVNYAFFFWLPLYLTDAyHWEESQADQLSIWYDFGGIIGSVLGGYITDKMGK 316
Cdd:COG2807 216 ---------LAWLL--TLFFGLQS----LLYYAVVAWLPPILRDA-GLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGD 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 317 RSPLIVAMLVCSIGSLYFYAHVGPHMFWnavvmttvgvtvsgpynLIVGSISIDLGSQPALA--------GNTQAMSTVS 388
Cdd:COG2807 280 RRPLLLLLGLLGLAGLLGLLLAPGSLPW-----------------LWAVLLGLGQGGLFPLAltliglraRTPAEAAALS 342
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1831518361 389 GLLDGTGSAGSAVGQLLIPIIQDDLG-WKAVFYVFMLLNGFAILAIL 434
Cdd:COG2807 343 GMAQSVGYLLAALGPLLVGALHDATGsWTAALLLLAALAVLMLVAGL 389
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
9-337 |
9.90e-15 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 75.83 E-value: 9.90e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 9 KVMVFVVTFVSYGLYHASRKALSGVKSSIKADWLSNSSgHAPLFTNEADAKHFLGSldaifmaayaaalFFWGWLGDRLN 88
Cdd:cd17343 1 QLTIFASMFVGYTLYYFNRKSFSFVLPSLMNELGLDKS-DLGLITSSQSLAYAISK-------------FIGGVLSDQIS 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 89 PKLVVAAGMVGSAVTLTLFGaipkWFNFYhAPYYIMTYVAfGLVQACGWPSEIAIMANWFGKGNRGFVMGVWAACQPVGN 168
Cdd:cd17343 67 ARWLFSSGLVLSGLTTVAFS----GSSSV-WVFSILWFLN-GLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAG 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 169 IFGSIFTA-MVLPLGYQYTFVFNSVLIALGAIVVVMAIDSSPNEEhedGVEAnrirllRRSSSSEPHHNFHGEPISLFKA 247
Cdd:cd17343 141 SLGPILATlLALSYGWRSTLSISGTVAVVMSVVCLLFIKNEPSDV---GLNN------IEEEESKGKKKKSPRGESTLKE 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 248 VLL-PGVLAYCICNACLKLVNYAFFFWLPLYLTDAYHWEESQADQLSIWYDFGGIIGSVLGGYITDKMGK---------- 316
Cdd:cd17343 212 LLLsPFLWLLSLGYLVVFGVKTAVTDWGQLFLIQDKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWAVAkhgsssrgnp 291
|
330 340
....*....|....*....|.
gi 1831518361 317 RSPLIVAMLVCSIGSLYFYAH 337
Cdd:cd17343 292 RMPLALVFMAGLTVSLHLFRV 312
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
77-434 |
7.53e-14 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 72.66 E-value: 7.53e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 77 LFFWGWLGDRLNPKLVVAAGMVGSAVTLTL---FGAIPKWFNFyhapyYIMTYVAFGLVQAcgwPSEIAIMAnWFGKGNR 153
Cdd:cd17475 48 MLPAGWLLDRFGERRVLAVGLLLMGAAALLmalVGSYPVLLVL-----LFLVGAGYGSVQP---GGGRAIMR-WFPPRER 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 154 GFVMGVWAACQPVGNIFGS-IFTAMVLPLGYQYTFVFNSVLIALGAIVVVMAIDSSPNEEHEDGVEANRIRLLRRSSSSe 232
Cdd:cd17475 119 GLAMGIRQTGVPLGGALAAaLLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPPAASAATESASTLLRSLKEVLRN- 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 233 phhnfhgepislfkavllPGVLAYCICNACLKLVNYAFFFWLPLYLTDAYHWEESQADQLSIWYDFGGIIGSVLGGYITD 312
Cdd:cd17475 198 ------------------RDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSD 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 313 KMGK---RSPLIVAMLVCSIGSLYFYAHVGPHMFW-NAVVMTTVGVTVSGPYNLIVGSISidlgsqpALAGNTQAmSTVS 388
Cdd:cd17475 260 RVFGgrrRPVLVITAAIAAAALLVLSLLSPGTPLWlLVLLLILLGLFAIGWNGLYLTLVA-------ESAGPEQA-GTAL 331
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1831518361 389 GLLDGTGSAGSAVGQLLIPIIQDDL-GWKAVFYVFMLLNGFAILAIL 434
Cdd:cd17475 332 GLANTINFIGIAIGPPLFGLLVDAThSYAPAWLALALLLVLAALLLL 378
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
79-434 |
8.01e-14 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 73.01 E-value: 8.01e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 79 FWGWLGDRLNPKL-----VVAAGMVGSAVTLTLFGAIPKWFNFYHAPYYIMTYVAFGLVQACGWPSEIAIMANWFGKGN- 152
Cdd:COG2211 65 LIGALSDRTRTRWgrrrpWILIGAIPLALSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEe 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 153 RGFVMGVWAACQPVGNIFGSIFTAMVL-------PLGYQYTFVFNSVLIALGAIVVVMAIDSSPNEEHEDGVEANRIRLL 225
Cdd:COG2211 145 RTRLSSWRFAFAGLGGLLASVLPPPLVaafggdaALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKESLKAL 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 226 RRSsssephhnfhgepislfkavllPGVLAYCICNACLKLVNYAFFFWLPLYLTDAYHWEESQADQLSIWYDFGGIIGSV 305
Cdd:COG2211 225 LKN----------------------RPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAP 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 306 LGGYITDKMGKRSPLIVAMLVCSIGSLYFYAhVGPHMFWNAVVMTTVGVTVSGPYNLIVGSISIDLGSQPALAGNTQAMS 385
Cdd:COG2211 283 LWPRLAKRFGKKKAFIIGLLLAALGLLLLFF-LGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTGRRREG 361
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1831518361 386 TVSGLLDGTGSAGSAVGQLLIPIIQDDLGWKA-----VFYVFMLLNGFAILAIL 434
Cdd:COG2211 362 LYFGIFTFAIKLGQALAGALAGLLLALFGYVAgaaqsPSALTGIRLLFFLLPAV 415
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
78-434 |
8.36e-13 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 70.12 E-value: 8.36e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 78 FFWGWLGDRLNPKLVVAAGMVGSAVTLTLFGAIPkWFNFYHAPYYIMTYVAfGLVQACGWPSEIAIMANWFGKGNRGFVM 157
Cdd:PRK11273 81 FIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFVP-WATSSIAVMFVLLFLC-GWFQGMGWPPCGRTMVHWWSQKERGGIV 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 158 GVWAACQPV-GNIFGSIFtamVLPLGY-------QYTFVFNSVLIALGAIVVVMAIDSS----PNEEHEDGVEANrirll 225
Cdd:PRK11273 159 SVWNCAHNVgGGLPPLLF---LLGMAWfndwhaaLYMPAFAAILVALFAFAMMRDTPQScglpPIEEYKNDYPDD----- 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 226 rrssSSEPHHN-FHGEPIsLFKAVLLPGVLAY-CICNACLKLVNYAFFFWLPLYLTDAYHWEESQADQLSIWYDFGGIIG 303
Cdd:PRK11273 231 ----YNEKHEQeLTAKQI-FMQYVLPNKLLWYiAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPG 305
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 304 SVLGGYITDKM--GKRSPL-IVAMLVCSIGSLYFYAHVGPHMFWNAVVMTTVGVTVSGPYNLIvGSISIDLGSQPAlAGN 380
Cdd:PRK11273 306 TLLCGWMSDKVfrGNRGATgVFFMTLVTIATIVYWLNPAGNPTVDMACMIVIGFLIYGPVMLI-GLHALELAPKKA-AGT 383
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1831518361 381 TQAMSTVSGLLDGTGSAGSAVGQLLipiiqDDLGWKAvfyVFMLLNGFAILAIL 434
Cdd:PRK11273 384 AAGFTGLFGYLGGSVAASAIVGYTV-----DFFGWDG---GFMVMIGGSILAVI 429
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
13-332 |
1.07e-12 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 69.57 E-value: 1.07e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 13 FVVTFVSYGLYHASRKALSGVKSSIKADWLSNSSGhaplftneadakhfLGSLDAIFMAAYAAALFFWGWLGDRLNPKLV 92
Cdd:cd17328 1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSL--------------AGLLQTVFIISYMVLSPIFGYLGDRYNRKWI 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 93 VAAGMVG-SAVTLTLfGAIPKWFNFyhapyyIMTYVAFGLVQACGWPSEIAIMANWFGKGNRGFVMGVWAACQPVGNIFG 171
Cdd:cd17328 67 LAVGILIwSAATLLS-SFAPNFWQL------LLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLG 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 172 SIFTAMV--LPLGYQYTFVFNSVL-IALGAIVVVMAIDsspneehedgveanrirllRRSSSSEPHHNFHGEPISLFK-A 247
Cdd:cd17328 140 YVVGGLVaqATGGWRWAFRVTGVLgVLLAILLLLFVRE-------------------PPRGAAEGGVMAKSTATSFLAdL 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 248 VLLPGVLAYCICNA---CLKLVNYAFFFWLPLYLTDAYHWEESQADQLSIWYD----FGGIIGSVLGGYITDKMGKRSPL 320
Cdd:cd17328 201 KALAKNPSFILSTLgftAVSFVTGALAFWAPTFFLRAFGVGDLSSADVGLIFGaitcIAGVLGVLLGGILADRLRRKTPR 280
|
330
....*....|..
gi 1831518361 321 IVAmLVCSIGSL 332
Cdd:cd17328 281 ADP-LVCAVGLL 291
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
12-334 |
1.94e-12 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 68.20 E-value: 1.94e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 12 VFVVTFVSYGLYHASRKALSGVKSSIKADwlsnssghapLFTNEADakhfLGSLDAIFMAAYAAALFFWGWLGDRLNPKL 91
Cdd:cd17488 4 ILASMFIGYAVFYLTRKSFNAAMPAMLAD----------LGLDKSD----IGILGSLFYITYGVSKFVSGLMSDRSNPRY 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 92 VVAAGMVGSAVTLTLFGAIPKWFNFYhapyyiMTYVAFGLVQACGWPSEIAIMANWFGKGNRGFVMGVWAACQPVGNIFG 171
Cdd:cd17488 70 FMGIGLIATGIINILFGFSSSLWAFA------VLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALI 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 172 SIFTAMV-LPLGYQYTFVFNsvlialGAIVVVMAIdsspneehedgVEANRIRllrrssssephhnfhGEPislfkavll 250
Cdd:cd17488 144 PILTGFAaLTYGWRAGMYVP------GIIAILMGI-----------VLCWRLR---------------DRP--------- 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 251 PGVLAYCICNACLKLVNYAFFFWLPLYLTDAYHWEESQADQLSIWYDFGGIIGSVLGGYITDKM--GKRSP--LIVAMLV 326
Cdd:cd17488 183 PYIWLLAFCYVLVYVVRTAINDWGNLYLSETHGYSLVKANSAVSLFEVGGLIGALVAGWGSDKLfkGNRGPmnLIFALGL 262
|
....*....
gi 1831518361 327 C-SIGSLYF 334
Cdd:cd17488 263 LvSVGALWL 271
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
77-434 |
1.95e-11 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 65.26 E-value: 1.95e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 77 LFFWGWLGDRLNPKLVVAAGMVGSAVTLTLFGAIPkwfnfyhaPYYIMTYVAFGLVQACG--WPSEIAIMANWFGKGNRG 154
Cdd:cd17324 51 ALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAP--------SFALLLLARALAGLAHGgfWAIAAAYAADLVPPEKRG 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 155 FVMGVWAACQPVGNIFGSIFTAMVLP-LGYQYTFVFNSVLIALGAIVVVMAIDSSPNEEHEDGVEANRIRLLRRSsssep 233
Cdd:cd17324 123 RAIGLVFSGLTLGLVLGRPLGGLLGQlLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGSLGLLSSLLLLLRN----- 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 234 hhnfhgepislfkavllPGVLAYCICNACLKLVNYAFFFWLPLYLTDAYHWEESQADQLSIWYDFGGIIGSVLGGYITDK 313
Cdd:cd17324 198 -----------------PRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADR 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 314 MGKRsPLIVAMLVCSIGSLYFYAhvgphmfwnavvmttvgvTVSGPYNLIVGSISIDLG------------SQPALAGNT 381
Cdd:cd17324 261 GGRR-ALLIALLLLAAALLLLTL------------------LGPSPLLLLVGLVLWGLGffaahsalqtrvLRLAPEARG 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1831518361 382 QAMSTVSGLLDGTGSAGSAVGQLLIpiiqDDLGWKAVFYVFMLLNGFAILAIL 434
Cdd:cd17324 322 LASSLYLAAYNLGGALGAALGGLVL----DHGGWAGVGWVGAALLLLALLLAL 370
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
62-434 |
4.37e-11 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 64.49 E-value: 4.37e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 62 LGSLDAIFMAAYAAALFFWGWLGDRLNPKLVVAAGMVGSAVTLTLFGAIPKWfnfyhaPYYIMTYVAFGLVQACGwpsEI 141
Cdd:COG0738 45 AGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSY------PLLLLALFLLGLGLGLL---DV 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 142 AI--MANWFGKGNRGFVMGVWAACQPVGNIFGSIFTAMVL----PLGYQYTFVFNSVLIALGAIVVVMAI--DSSPNEEH 213
Cdd:COG0738 116 AAnpYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLIllglSLSWHLPYLILAVLLLLLALLFLRSKlpEIEEEEEE 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 214 EDGVEANRIRLLRrssssephhnfhgepislFKAVLLPGVLAYCICnaclkLVNYAFFFWLPLYLTDAYHWEESQADQLS 293
Cdd:COG0738 196 AAGSAASLKSLLK------------------NPRLLLGGLAIFLYV-----GAEGAIGDWLPLYLKDVLGLSEATAALGL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 294 IWYDFGGIIGSVLGGYITDKMGKRSPLIVAMLVCSIGSLYFYahVGPHMFWNAVVMTTVGVTVSGPYNLIVGSISIDLGS 373
Cdd:COG0738 253 SLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLAL--LAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGK 330
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1831518361 374 QPALAGNTQAMstvsglldgTGSAGSAVGQLLIPIIQDDLGWKAVFYVFMLLngFAILAIL 434
Cdd:COG0738 331 RTAAAVSAVLI---------MGIVGGAIGPPLIGFLADAFGLRAAFLVPLVC--YLLILLL 380
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
77-402 |
5.55e-11 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 63.73 E-value: 5.55e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 77 LFFWGWLGDRLNPKLVVAAGMVGSAVTlTLFGAIpkwfnfyhAPYYIMtYVAFGLVQ----ACGWPSEIAIMANWFGKGN 152
Cdd:cd17321 48 LLLAGRLGDRFGRKRVFLIGLALFGLA-SLLCAL--------APSLAF-LIAARALQgigaAAIMPASLALIAATFPGER 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 153 RGFVMGVWAACQPVGNIFGSIFTAMVLP-LGYQYTFVFNsvlIALGAIVVVMAidsspneehedgveanrirllrrssss 231
Cdd:cd17321 118 RGRALGLWGAVVGIGAALGPLLGGLLLElFGWRWIFLIN---VPIGLVALLLA--------------------------- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 232 ephhnfhgepislfkavllPGVLAYCICNACLKLVNYAFFFWLPLYLTDAYHWEESQADQLSIWYDFGGIIGSVLGGYIT 311
Cdd:cd17321 168 -------------------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLA 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 312 DKMGKRSPLIVAMLVCSIGsLYFYAHVGPHmfwnavvmttvgvtvSGPYNLIVGSISIDLGSQPALAGNT-QAMSTV--- 387
Cdd:cd17321 229 DRFGPRLVLVAGLLLTAVG-LLLLALLGAD---------------SSVWLLLPGLVLLGLGLGLFATPLTnAALSSVpke 292
|
330 340
....*....|....*....|
gi 1831518361 388 -----SGLLDGTGSAGSAVG 402
Cdd:cd17321 293 kagaaSGILNTARQLGGALG 312
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
81-434 |
7.65e-10 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 60.26 E-value: 7.65e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 81 GWLGDRLNPKLVVAAGMVGSAVTLTLFGAIPKwfnfyhapYYIMTYVAF--GLVQACGWPsEIAIMANWFGKGNRGFVMG 158
Cdd:cd17478 52 GYLADRKPRRYLLPLGPLLTGLGLSLLGFAPN--------YWLLLLLVAlaGIGSAAFHP-EGARLASQAAGGRRGLAMS 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 159 VWAACQPVGNIFGSIFTAMVL-PLGYQYTFVFnsvlIALGAIVVVMAIDSSPNEEHEDGVEANRIRLLRRSSssephhnf 237
Cdd:cd17478 123 IFSVGGNLGFALGPLIAAALVaLFGGLGLLIL----LIIPGLAVALLLLRLRPLKKPEAKKAAAKSSARSTL-------- 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 238 hgepISLFKAVLLPGVLAYCICnaclkLVNYAFFFWLPLYLTDaYHWEESQADQLSIWYDFGGIIGSVLGGYITDKMGKR 317
Cdd:cd17478 191 ----KGVWRALLLLLIIVFLRS-----WVLSSLTTFLPFYLVQ-RGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRR 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 318 SPLIVAMLvCSIGSLYFYAHVGPHMFWNAVVMTTVGVTVSGPYNLIVGsisidlgsQPALAGNtqaMSTVSGLLDGTGSA 397
Cdd:cd17478 261 RVIIASLL-LAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLA--------QELLPGN---VGLASGLMMGLSFG 328
|
330 340 350
....*....|....*....|....*....|....*..
gi 1831518361 398 GSAVGQLLIPIIQDDLGWKAVFYVFMLLNGFAILAIL 434
Cdd:cd17478 329 LGGIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
17-333 |
2.21e-08 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 56.26 E-value: 2.21e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 17 FVSYGLYHASRKALSGVKSSIKADWLSNSSGhaplftneadakhfLGSLDAIFMAAYAAALFFWGWLGDRLNPKLVVAAG 96
Cdd:PRK11663 29 YLGYALFYFTRKSFNAAMPEMLADLGLSRSD--------------IGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIG 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 97 MVGSAVTLTLFGAIPKWFNFyhapyyIMTYVAFGLVQACGWPSEIAIMANWFGKGNRGFVMGVWAACQPVGNIFGSIFTA 176
Cdd:PRK11663 95 LIATGIINILFGFSSSLWAF------ALLWVLNAFFQGWGWPVCAKLLTAWYSRTERGGWWAIWNTAHNVGGALIPLVVG 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 177 MV-LPLGYQYTFVFNSVLIALGAIVVVMAIDSSPNEEHEDGVEAnrirllRRSSSSEPHHNFHGEPIS----LFKAVLL- 250
Cdd:PRK11663 169 AIaLHYGWRYGMMIAGIIAIVVGLFLCWRLRDKPQAMGLPSVGE------WRHDALELAQQQEGAGLSrkeiLTKYVLLn 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 251 PGVLAYCICNACLKLVNYAFFFWLPLYLTDAYHWEESQADQLSIWYDFGGIIGSVLGGYITDKM--GKRSP--LIVAM-L 325
Cdd:PRK11663 243 PYIWLLSFSYVLVYVVRAAINDWGNLYMSETLGVDLVTANSAVSMFELGGFIGALVAGWGSDKLfnGNRGPmnLIFAAgI 322
|
....*...
gi 1831518361 326 VCSIGSLY 333
Cdd:PRK11663 323 LLSVGSLW 330
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
130-329 |
2.24e-08 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 56.10 E-value: 2.24e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 130 GLVQACGWPSEIAIMANWFGKGNRGFVMGVWAACQPVGNIFGSIFTAMVLPL-------GYQYTFVFNSVLIALGAIVVV 202
Cdd:cd17327 105 GLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKIlgvgglaGWRWLFIIEGLITIIIGLVIF 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 203 MAIDSSP------NEEHEDGVeanRIRLLRRSSSSEphhNFHGEPISLFKAVLLPGVLAYCICNACLKLVNYAFFFWLPL 276
Cdd:cd17327 185 FWLPDNPskawflTEEEKELA---VERLRANQTGKG---DQKFKWKQIKEAFKDPRTWLLFLFFFCSQITNNGISNFLPL 258
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1831518361 277 YLTDAYhWEESQADQLSIWYDFGGIIGSVLGGYITDKMGKRSPLIVAMLVCSI 329
Cdd:cd17327 259 ILKSLG-FYSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGLFAIFACVLAL 310
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
81-338 |
3.11e-08 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 55.82 E-value: 3.11e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 81 GWLGDRLNPKLVVAAGMVGSAVTLTLFGAIPKWFnfyHAPYYIMT--YVAFGLVQACGWPSEIAIMANWFGKGNRGFVMG 158
Cdd:PRK09556 85 GYYADGKNTKQFLPFLLILSAICMLGFGASLGSG---SVSLGLMIalWALSGFFQSTGGPCSYSTITRWTPRRKRGRFLG 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 159 VWAACQpvgNIFGSIfTAMVLPLGYQY--------TFVFNSVlIALgaIVVVMAIDSSPNEEHEDGVeaNRIRLLRRSSS 230
Cdd:PRK09556 162 FWNISH---NLGGAG-AGGVALWGANYffdghvigMFIFPSI-IAL--IIGFIGLRYGSDSPEELGW--GKAEEIFGEPI 232
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 231 SEPHHNFHGEPIS---LFKAVLL--PGVLAYCICNACLKLVNYAFFFWLPLYLTDAYHWEESQADQLSIWYDFGGIIGSV 305
Cdd:PRK09556 233 SEEDKETESTDMTkwqIFVEYVLknPVIWLLCFANIFLYIVRIGIDNWSPVYAFQELGFSKEDAINTFTLFEIGALVGSL 312
|
250 260 270
....*....|....*....|....*....|....
gi 1831518361 306 LGGYITDKMGKRSPLIVAM-LVCSIGSLYFYAHV 338
Cdd:PRK09556 313 LWGWLSDLANGRRALVACIaLALIIFTLGVYQHA 346
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
78-434 |
8.68e-08 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 53.76 E-value: 8.68e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 78 FFWGWLGDRLNPKLVVAAGMVGSAVTlTLFGAIpkwfnfyhAPYYIMtYVAFGLVQACG----WPSEIAIMANWFGKGNR 153
Cdd:cd17316 54 LLFGYLGDRIGRKKALILTLLLFGLA-TLLIGL--------LPTPIL-LLVLRFLQGIGiggeYPGASTYVAEFAPSKRR 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 154 GFVMGVWAACQPVGNIFGSIFTAMVLPLgyqYTFVFN-SVLIALGAIVVVMAIdsspneehedgveanrirLLRRSssse 232
Cdd:cd17316 124 GFALGLLQSGWALGALLAALVASLLIPL---LSGDWGwRILFLIGALPALLAL------------------LLRRR---- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 233 phhnfhgepislfkaVLLPGVLaycicNACLKLVNYAFFFWLPLYLTDAYHWEESQADQLSIWYDFGGIIGSVLGGYITD 312
Cdd:cd17316 179 ---------------TLLLILL-----WFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSD 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 313 KMGKRsPLIVAMLVCSIGSLYFYAHVGPHMFWNAVVMTTVGVTVSGPYNLIVGSISIDLGSqpalagnTQAMSTVSGLLD 392
Cdd:cd17316 239 RIGRK-KTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFP-------TEVRATGVGLSY 310
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1831518361 393 GTGSAGSAVGQLLIP-IIQDDLGWKAVFYVFMLLNGFAILAIL 434
Cdd:cd17316 311 NLGRLGGGGAPPLIAlLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
67-207 |
1.25e-06 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 50.19 E-value: 1.25e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 67 AIFMAAYAAALFFWGWLGDRLNPKLVVAAGMVGSAVTLTLFGAIPkwfnfyhapyYIMTYVAFGLVQACG----WPSEIA 142
Cdd:COG0477 56 SAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAP----------SPELLIAARALQGIGagglMPGALA 125
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1831518361 143 IMANWFGKGNRGFVMGVWAACQPVGNIFGSIFTAMVLP-LGYQYTFVFNSVLIALGAIVVVMAIDS 207
Cdd:COG0477 126 LIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAaLGWRWIFLINAPLGLLALVLRLRLPES 191
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
256-434 |
1.76e-06 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 50.12 E-value: 1.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 256 YCICNACLKLVNYAFFFWLPLYLTDaYHWEESQADQLSIWYDFGGIIGSVLGGYITDKMGKRSPLIVAMLVCSIGSLYFY 335
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQS-FGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 336 ahvGPHMFWNAVVMTTVGVTVSGPYNLIVGSISIDLGSQpalagntQAMSTVSGLLDGTGSAGSAVGQLLIPII--QDDL 413
Cdd:cd06174 80 ---FAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPE-------RERGRALGLLQAFGSVGGILGPLLGGILasSLGF 149
|
170 180
....*....|....*....|.
gi 1831518361 414 GWKAVFYVFMLLNGFAILAIL 434
Cdd:cd06174 150 GWRAVFLIAAALALLAAILLL 170
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
257-434 |
2.00e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 49.72 E-value: 2.00e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 257 CICNACLKLVNYAFFFWLPLYLTDAYHWEESQADQLSIWYDFGGIIGSVLGGYITDKMGKRSPLIVAMLVCSIGSLYFYA 336
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 337 HVGPHMFWnavVMTTVGVTVSGPYNLIVGSISIDLGSQPALAgntqamsTVSGLLDGTGSAGSAVGQLLIPIIQDDLGWK 416
Cdd:pfam07690 82 ASSLWLLL---VLRVLQGLGAGALFPAALALIADWFPPEERG-------RALGLVSAGFGLGAALGPLLGGLLASLFGWR 151
|
170
....*....|....*...
gi 1831518361 417 AVFYVFMLLNGFAILAIL 434
Cdd:pfam07690 152 AAFLILAILSLLAAVLLL 169
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
78-205 |
3.10e-06 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 49.10 E-value: 3.10e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 78 FFWGWLGDRLN--PKLVVAAGMVGSAVTLTLFGAIPkwfnfyHAPYYIMTYVAFGLVQACGWPSEIAIMANWFGKGNRGF 155
Cdd:COG2271 234 LLGGWLSDRLGrrRKLVLAIGLLLAALALLLLALLP------SPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGT 307
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1831518361 156 VMGVWAACQPVGNIFGSIFTAMVLPL-GYQYTFVFNSVLIALGAIVVVMAI 205
Cdd:COG2271 308 ASGLVNTFGFLGGALGPLLVGYLLDAtGYQAAFLLLAALALLAALLALLLL 358
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
137-344 |
8.79e-06 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 47.68 E-value: 8.79e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 137 WPSEIAIMANWFGKGNRGFVMGVWAACQPVGNIFGSIFTAMVLPL-----GYQYTFVFnSVLIALGAIVVVMAIDSSPne 211
Cdd:cd17371 105 WAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLlppeiAWRVLFLL-GALPALLVLFIRRFVKEPP-- 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 212 ehedgvEANRIRLLRRSSSSEPHhnfhgePISLFKAVLLPGVLAYCICNACLKLVNYAFFFWLPLYLTDAYHWEESQADQ 291
Cdd:cd17371 182 ------QWQAARAARRHFADRPS------LRELFSPPLLRTTLLASLLATGALGGYYGITTWLPSYLTGERGLSFEGSAG 249
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 1831518361 292 LSIWYDFGGIIGSVLGGYITDKMGKRSPLIVAMLVCSIG-SLYFYAHVGPHMFW 344
Cdd:cd17371 250 YLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISiLLYFFLPLSPTLIL 303
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
81-436 |
1.08e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 47.61 E-value: 1.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 81 GWLGDRLNPKLVVAAGMVGSAVTLTLFGAIPKWFNFYHAPYYIMTyVAFGLVQACGWPSEIAIMANWFGKGNRGFVMGVW 160
Cdd:cd06173 55 GVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLA-FLLGIASAFFGPARQALLPELVPKEQLVRANALN 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 161 AACQPVGNIFGSIF-TAMVLPLGYQYTFVFNSVLIALGAIVVVmaidsspneehedgveanRIRLLRRSSSSEPHHNFHG 239
Cdd:cd06173 134 SLATQLARIIGPALgGLLVALLGPGGAFAINALSFLLSALLLL------------------FIRRPPPAAPGESSSLLLR 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 240 EPISLFKAVLLPGVLAYCICNACL-KLVNYAFFFWLPLYLTDAYHWEESQADQLSIWYDFGGIIGSVLGGYITDKMGKRS 318
Cdd:cd06173 196 DLREGLRYLRRSPLLRLLLLALALfALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGR 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 319 PLIVAMLVCSIGSLYFYAhvgPHMFWNAVVMTTVGVTVSGPYNLIVGSIsIDLGSQPALAGNtqamstVSGLLDGTGSAG 398
Cdd:cd06173 276 LLLIGALLLGLALLVLGL---SPSLWLLLAALFLLGLAGGLFNVPLNTL-LQLRVPDELRGR------VFSVYNALNSGA 345
|
330 340 350
....*....|....*....|....*....|....*...
gi 1831518361 399 SAVGQLLIPIIQDDLGWKAVFYVFMLLNGFAILAILKR 436
Cdd:cd06173 346 MPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
81-342 |
1.15e-05 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 47.57 E-value: 1.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 81 GWLGDRLNPKLVVAAGMVGSAVTLTLFGAIPKWFNFyhapyyimtyVAFGLVQACG----WPSEIAIMANWFGKGNRGFV 156
Cdd:cd17503 52 GWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASL----------IIFRILQGFGggvlIPLAQTILLRIYPPEKRGAA 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 157 MGVWAACQPVGNIFGSIFT-AMVLPLGYQYTFVFNsVLIALGAIVVVMAIDsspneehedgveanrIRLLRrssssepHH 235
Cdd:cd17503 122 MGLVGLVILLAPAIGPTLGgWLTDNLSWRWIFYIN-LPIGILALLLAPLLD---------------LRLFK-------DR 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 236 NFhgepislfkavllpgvLAYCICNACLKLVNYAFFFWLPLYLTDAYHWEESQADQLSIWYDFGGIIGSVLGGYITDKMG 315
Cdd:cd17503 179 NF----------------TLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFG 242
|
250 260
....*....|....*....|....*..
gi 1831518361 316 KRSPLIVAMLVCSIGsLYFYAHVGPHM 342
Cdd:cd17503 243 PRLLLLAGLLLLALG-TLLLAFLTPDT 268
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
67-434 |
1.18e-05 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 47.27 E-value: 1.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 67 AIFMAAYAAALFFWGWLGDRLNPKLVVAAGMVGSAVTLTLFGAIPKWFNFYhapyyimtyVAFGLVQ----ACGWPSEIA 142
Cdd:cd17355 45 TVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLY---------LLWGLLGgggaGTLAAVAFA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 143 IMANWFGKGNRGFVMGVWAAcqpvGNIFGSIftaMVLPLGYQ--YTFVFNSVLIALGAIVVVMAIDSSPneehedgvean 220
Cdd:cd17355 116 TVAAWWFERRRGLALGILTA----GGGLGSL---VFLPLGAAliEAFGWRTALLVLALLALLVLVPVLL----------- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 221 rirLLRRSSSSEPHHNFHGEPISLFKAVLLPGV---------LAYCICNACLklvnYAFFFWLPLYLTDAYHWEESQADQ 291
Cdd:cd17355 178 ---LLRRRPADLALRAYDDASPASPGSTLKEALrsasfwllaLAFFLCGFAV----VGLIVHLVPYLADRGISPAAAAVA 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 292 LS-IWydFGGIIGSVLGGYITDKMGKRSPLIVAMLVCSIG-SLYFYAHVGPHMFWNAVVMttvgvtvsgpYNLIVGSISI 369
Cdd:cd17355 251 LAlIG--LFNIVGRLLSGWLGDRYSPRRLLAASYALRALGlALLLLLPFPPLALLLFAAL----------FGLGWGATVP 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1831518361 370 DLGSQPALAGNTQAMSTVSGLLDGTGSAGSAVGQLLIPIIQDDLG-WKAVFYVFMLLNGFAILAIL 434
Cdd:cd17355 319 LTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGsYTAAWALAVALGLIAALLVL 384
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
81-434 |
1.38e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 47.18 E-value: 1.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 81 GWLGDRLNPKLVVAAGMVGSAvtltLFGAIPKWFNFYHApyYIMTYVAFGLVQACGWPSEIAIMANWFGKGNRGFVMGVW 160
Cdd:cd17473 56 GWLADRFGRKRLLIAGLLLYG----IGGVAGLFLDSLYA--LLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQ 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 161 AACQPVGNIFGSIFTAMVLPLGYQYTFvfnsvLIALGAIVVVMAIdsspneehedgveanrIRLLRRSSSSEPHHNFHGE 240
Cdd:cd17473 130 SAAMSLGGVVFLLLGGALAEIGWRAPF-----LVYLLALPVLILV----------------LLFLPEPARKSKSAASPGA 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 241 PISlfKAVLLPGVLAYCICNACLKLVNYAFFFWLPLYLTDAYHWEESQADQLSIWYDFGGIIGSVLGGYITDKMGKRSPL 320
Cdd:cd17473 189 ATA--AALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLL 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 321 IVAMLVCSIGsLYFYAHVgphmfwnavvmttvgvtvSGPYNLIVGSISIDLG---SQPALagNTQAMSTVS----GLLDG 393
Cdd:cd17473 267 AIGFALMALG-FLLLALA------------------SGLWVVLLGAILAGLGfglLLPTL--NSWAMSLVPpelrGRAMG 325
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1831518361 394 TGSAGSAVGQLLIPIIQDDLGWKAVFY--VFMLLNGFAILAIL 434
Cdd:cd17473 326 IVTSAFFLGQFLSPLVLGPLVNLTGGLsgAFLILGVLALVLAI 368
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
241-335 |
2.28e-05 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 46.40 E-value: 2.28e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 241 PISLFKAVLLPGVLAYCICNACLKLVNYAFFFWLPLYLTDAYHWEESQADQLSIWYDFGGIIGSVLGGYITDKMGKRSPL 320
Cdd:cd17502 157 PIGGLALALLRTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRYKPL 236
|
90
....*....|....*.
gi 1831518361 321 IVA-MLVCSIGSLYFY 335
Cdd:cd17502 237 IVIgTILMSVGAGLLT 252
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
78-332 |
3.25e-05 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 46.01 E-value: 3.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 78 FFWG---------WLGDRLNPKLVVAAGMVGSAVtLTLFgaIPkWFNFYHAPYYIMTYVAFGLVQACGWPSEIAIMANWF 148
Cdd:cd17380 43 FFWGyaltqvlggYLADRFGGKKVLLLAVALWSL-ATLL--TP-LLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWV 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 149 GKGNRGFVMGVWAACQPVGNIFGSIFT-AMVLPLGYQYTFVFNSVLIALGAIVVVmaidsspneehedgveanrirllrr 227
Cdd:cd17380 119 PVSERSRAVSIVTAGSYLGTLLGGLIGpLLLEYYGWPSVFYFFGLLGLLWALVWL------------------------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 228 ssssephhnfhgepislfkaVLLPGVLAYCICNACLKLVNYAFFFWLPLYLTDAYhweesQADQLSIWYD----FGGIIG 303
Cdd:cd17380 174 --------------------IYLPPVWAIIVAHFCMNWGFYILLSWLPTYFHEVL-----VPLAKGWVFNvvpwLVMFPS 228
|
250 260 270
....*....|....*....|....*....|.
gi 1831518361 304 SVLGGYITDKMGKR--SPLIVAMLVCSIGSL 332
Cdd:cd17380 229 SNVAGWLADHLISRgwTVTSVRKLMQSIGFL 259
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
81-342 |
5.08e-05 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 45.45 E-value: 5.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 81 GWLGDRLNPKLVVAAGMVGSAVTLTLFGAIPKwfnfyhapyyIMTYVAFGLVQACG----WPSEIAIMANWFGKGNRGFV 156
Cdd:TIGR00711 58 GWLAKRFGTRRLFLISTFAFTLGSLLCGVAPN----------LELMIIFRVIQGFGggplIPLSFSTLLNIYPPEKRGRA 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 157 MGVWAACQPVGNIFGSIFTAMVLPLgYQYTFVFnSVLIALGAIVVVMAIDSSPNEEHEDGVEANRIRLLRRSS------- 229
Cdd:TIGR00711 128 MAIWGLTVLVAPALGPTLGGWIIEN-YHWRWIF-LINVPIGIIVVVVAFFILPRDKPAASENFDFLGLLLLSVglgslly 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 230 --SSEPHHNFHGEPISLFKAVL-LPGVLAY-------------------------CICNACLKLVNYAFFFWLPLYLTDA 281
Cdd:TIGR00711 206 glSEGPERGWFDSNEILILSITgLVAIIAFvvweltddnplvdlrlfkyrnftigCVYMSLLGLGLYGSFYLLPLYLQQV 285
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1831518361 282 YHWEESQADQLSIWYDFGGIIGSVLGGYITDKMGKRSPLIVAMLVCSIGSLYFYAHVGPHM 342
Cdd:TIGR00711 286 LGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRKLVTIGLILYAVGFYWRAFTFTPDT 346
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
78-433 |
5.34e-05 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 45.24 E-value: 5.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 78 FFWGWLGDRLNPKLVVAAGMVGSAVTLTLFgaipkwFNFYHAPYYIMTYVAFGLVQACGWPSEIAIMANWFGKGNRGFVM 157
Cdd:cd17477 49 PLVPRLIRRVGHIRAFAAGAAITAVSVLLL------ALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVL 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 158 GVWAACQPVGNIFGSIFTAMVLPLGYQyTFVFNSVLIALGAIVVVMAIDSSPNEEHEdgveanrirllrrssssephhnf 237
Cdd:cd17477 123 GLYSTVLGLGFALGPLLLALVGTAGAL-PFLIAAVLLLLALVPLLLTRRAAPEIEEA----------------------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 238 hgEPISLFKAV-LLPGVLAYCICNAclkLVNYAFFFWLPLYLTDAyHWEESQADQLSIWYDFGGIIGSVLGGYITDKMGK 316
Cdd:cd17477 179 --ESISLRRLLrIAPLALLGAFVAG---FLEGAFYSLLPLYGLRL-GLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDR 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 317 RSPLIVAMLVCSIGSLyFYAHVGPHMFWNAVVMTTVGVTVSGPYNLIVgSISIDLGSQPALAGNTQAMSTVSGLldgtgs 396
Cdd:cd17477 253 RRVLLGCALLGALAAL-LLPLVPGLPLALLVLLFLWGGAAGPLYTLAL-ALAGDRLPGDELVAANAALLLLYGL------ 324
|
330 340 350
....*....|....*....|....*....|....*..
gi 1831518361 397 aGSAVGQLLIPIIQDDLGWKAVFYVFMLLNGFAILAI 433
Cdd:cd17477 325 -GSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
248-434 |
8.61e-05 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 44.49 E-value: 8.61e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 248 VLLPGVLAYCICNAclklVNYAFFFWLPlYLTDAYHWEESQADQLSIWYDFGGIIGSVLGGYITDKMGKRSPLIVAMLVC 327
Cdd:COG2223 6 VLLLATLAFFLAFG----VWYLWSVLAP-PLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 328 SIGSLYF-YAHVGPHMFWnavvmttvgvtvsgpYNLIVGsisIDLGSqpALAGNTQAMS---------TVSGLLDGTGSA 397
Cdd:COG2223 81 GIGLLLLaLAVSYWLLLL---------------LGLLLG---IGGGG--SFAVGIALVSkwfppdrrgLALGLAAGGGNL 140
|
170 180 190
....*....|....*....|....*....|....*..
gi 1831518361 398 GSAVGQLLIPIIQDDLGWKAVFYVFMLLngFAILAIL 434
Cdd:COG2223 141 GAAVAAFLAPLLIAAFGWRNAFLILGIL--LLVVAVL 175
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
168-343 |
9.07e-05 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 44.41 E-value: 9.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 168 NIFGSIFTAMVLP-LGYQYTFVFNSVLIALGAIVVVMAIDSSPNEEHEDGVEANRIRLLRRSsssephhnfhgepISLFK 246
Cdd:cd17337 139 PVLGSYLASFTIPvIGEIGTLWLSLVFVALGGLIALFLVRDRTGEQPLANPSEEPLKELLSG-------------ITILF 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 247 AV--LLPGVLAYCICNACLklvnYAFFFWLPLYLTDAYHWEESQAdqLSIWYDFG--GIIGSVLGGYITDKMGKRSPLI- 321
Cdd:cd17337 206 RNpkIAIGGIVRIINTLSQ----FGFPVFMPLYFTDTGGFSTSQW--LQIWGIIFlvNIFFNLIFGILGDKIGWRRTVRw 279
|
170 180
....*....|....*....|..
gi 1831518361 322 VAMLVCSIGSLYFYAhvGPHMF 343
Cdd:cd17337 280 FGGVGCAISTLLFYY--VPQLF 299
|
|
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
164-346 |
1.29e-04 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 44.14 E-value: 1.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 164 QPVGNIFGSIFTAMVLP-----LGYQYTFVFNSVLIALGAIVVVMAIDsspneehedgveanrirllRRSSSSEPHHNFH 238
Cdd:cd17485 133 QVVGYKLGSLLGGGGLLwlydlIGWQSLLLSLAALYLLLLLPVLFLRE-------------------LELPQQPPASERG 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 239 GEPISLFKAVL-LPGVLAYCICNACLKLVNYAFFFWLPLYLTDAyHWEESQADQLSIWYDFG-GIIGSVLGGYITDKMGK 316
Cdd:cd17485 194 AALKASLRAFLrRPGTRWLLLFLLLYKLGEQGALAMLPPFLVDR-GFSLSQIGLLSGVGGSLvSIAGSLLGGYLLKRRGR 272
|
170 180 190
....*....|....*....|....*....|..
gi 1831518361 317 RSPLIVA--MLVCSIGSLYFYAHVGPHMFWNA 346
Cdd:cd17485 273 RRLLLLGglLRLLLLGLYTLLALGGSGLNWVL 304
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
3-334 |
1.58e-04 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 43.88 E-value: 1.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 3 QTMSSRKVMVFVVTFVSYGLYHASRKALSGVKSSIKADW-LSNSSGHaplftneadakhFLGSLDAIFMAAYAaalFFWG 81
Cdd:TIGR00895 9 QPLSRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWgLDPVQLG------------FLFSAGLIGMAFGA---LFFG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 82 WLGDRLNPKLVVAAGMVGSAVtLTLFGAIPKWFnfyhaPYYIMTYVAFGLVQACGWPSEIAIMANWFGKGNRGFVMGVWA 161
Cdd:TIGR00895 74 PLADRIGRRRVLLWSILLFSV-FTLLCALATNV-----TQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMF 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 162 ACQPVGNIFGSIFTAMVLP-LGYQYTFVFNSVLIALGAIVVVMAIDSSPNEEHEDGVEANRIRLLRRSSSSEPHHNFHGE 240
Cdd:TIGR00895 148 CGYPIGAAVGGFLAGWLIPvFGWRSLFYVGGIAPLLLLLLLMRFLPESIDFLVSKRPETVRRIVNAIAPQMQAEAQSALP 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 241 PIS------------LFKAVLLPGVLAYCICNACLKLVNYAFFFWLPLYLTDAyHWEESQADQLSIWYDFGGIIGSVLGG 308
Cdd:TIGR00895 228 EQKstqgtkrsvfkaLFQGKTARITVLLWLLYFMLLVGVYFLTNWLPKLMVEL-GFSLSLAATGGALFNFGGVIGSIIFG 306
|
330 340 350
....*....|....*....|....*....|
gi 1831518361 309 YITDKMGKRS----PLIVAMLVCSIGSLYF 334
Cdd:TIGR00895 307 WLADRLGPRVtallLLLGAVFAVLVGSTLF 336
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
260-344 |
2.07e-04 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 43.41 E-value: 2.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 260 NACLKLVNYAFFFWLPLYLTDAYHWEESQADQLSIwYDFGGIIGSVLGGYITDKMGKRSPLIVAMLVCSIGSLYFYAHVG 339
Cdd:pfam00083 20 GAFLTLIDFFKNFGLSKSVSSLAALSVLSGLIVSI-FSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKG 98
|
....*
gi 1831518361 340 PHMFW 344
Cdd:pfam00083 99 KWSVY 103
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
48-203 |
1.76e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 40.25 E-value: 1.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 48 HAPLFTNEADAKHFLGSLDAIFMAAYAAALFFWGWLGDRLNPKLVVAAGMVGSAVTLTLFG-AIPKWFNFYHAPYYIMTY 126
Cdd:cd17330 22 YVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGlSRNLWLLFLARFLDGLTG 101
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1831518361 127 VAFGLVQACgwpseIAIMANwfgKGNRGFVMGVWAACQPVGNIFGSIFTA-MVLPLGYQYTFVFNSVLIALGAIVVVM 203
Cdd:cd17330 102 GNVSVAQAY-----IADITD---EEERAKAFGIISAAFGLGFILGPALGGfLSTPYGYALPFLVAAALALLNLVLVLF 171
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
265-436 |
1.91e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 40.34 E-value: 1.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 265 LVNYAFFFWLPL--YLTDAYHWEESQADQLSIWYDFGGIIGSVLGGYITDKMGKRSPLIVAMLVCSIGSLYFYAHVGPHM 342
Cdd:COG2814 21 LSGLGIGIVLPAlpLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 343 FWNAVvmttvgvtvsgpynLIVG-SISIDLGSQPALAGNT---QAMSTVSGLLDGTGSAGSAVGQLLIPIIQDDLGWKAV 418
Cdd:COG2814 101 LLAAR--------------FLQGlGAGALFPAALALIADLvppERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWV 166
|
170
....*....|....*...
gi 1831518361 419 FYVFMLLNGFAILAILKR 436
Cdd:COG2814 167 FLVNAVLALLALLLLLRL 184
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
48-172 |
2.21e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 40.09 E-value: 2.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 48 HAPLFTNEADAKHFLGSLD-AIFMAAYAAALFFWGWLGDRLNPKLVVAAGMVGSAVTLTLFGAIPkwfNFYHAPYYIMTY 126
Cdd:pfam07690 222 YLPLYQEVLGLSALLAGLLlGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLS---LTLSSLWLLLAL 298
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1831518361 127 VAFGLVQACGWPSEIAIMANWFGKGNRGFVMGVWAACQPVGNIFGS 172
Cdd:pfam07690 299 LLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
79-329 |
2.44e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 39.84 E-value: 2.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 79 FWGWLGDRLNPKLVVAAG--MVGSAVTLTLFGAipkwfNFYHapyYIMTY-VAFGLVQACGWPSEIAIMANWFGKgNRGF 155
Cdd:cd17352 57 LSSALVNRFGCRPVAIAGglLAALGLLLSSFAT-----SLWQ---LYLTYgVLGGLGLGLIYSPAIVIVGQYFEK-KRGL 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 156 VMGVWAACQPVGNIFGSIFTAMVLP-LGYQYTFVFNSVLIALGAIVVVMaidsspneehedgveanrIRLLRRsssseph 234
Cdd:cd17352 128 ATGIAVAGSGVGTFVFPPLLRYLLDnYGWRGALLILGGLCLNLCVCGLL------------------LRLLKD------- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 235 hnfhgepislfkavllPGVLAYCICNACLKLVNYAFFFWLPLYLTDaYHWEESQADQL-SIWyDFGGIIGSVLGGYITDK 313
Cdd:cd17352 183 ----------------PTFVLLALGVSFAMLGFFVPFVYLPSYAKS-LGIDESDAAFLlSII-GISDIVGRILLGLLADK 244
|
250
....*....|....*...
gi 1831518361 314 MGKRSPL--IVAMLVCSI 329
Cdd:cd17352 245 PRIGRLYlyIFTLLILGL 262
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
81-283 |
3.57e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 39.52 E-value: 3.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 81 GWLGDRLNPKLVVAAGMVGSAVTLTLFGaipkwfnFYHAPY-YIMTYVAFGLVQACGWPSEIAIMANWFGKGNRGFVMGV 159
Cdd:cd17329 56 GRLADRFGRKPVMLAGLLLRALGFALLG-------FAHSPWlFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSL 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 160 WAACQPVGNIFGSIFTAMVLPLGYQYTFVFNSVLIALGAIVVVMAIDSSPNEEHEDGVEANRIRLLrrssssephhnfhg 239
Cdd:cd17329 129 LYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILRGYK-------------- 194
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1831518361 240 ePISLFKAVLLpgvlaYCICNACLKLVNYAFFFWLPLYLTDAYH 283
Cdd:cd17329 195 -IVLRDRAFLL-----FLLASFLISLIYFQLESTLPVYVVEILG 232
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
67-205 |
5.69e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 38.75 E-value: 5.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518361 67 AIFMAAYAAALFFWGWLGDRLNPKLVVAAGMVgsavtLTLFGaipkWFNFYHAPYYIMTYVAFGLVQACG----WPSEIA 142
Cdd:cd17353 45 TLTIVFLAISAPFAGRLVDRGGPRKAILIGGI-----LFGLG----FILSAFAISLPLLFLGYGVLGGIGagigYITPVS 115
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1831518361 143 IMANWFgKGNRGFVMGVWAACQPVGN-IFGSIFTAMVLPLGYQYTFvfnsvlIALGAIVVVMAI 205
Cdd:cd17353 116 TAVKWF-PDKRGLATGIVIAGFGLGSlIFSPLIAYLINTVGVPTTF------LILGIIFLIIIV 172
|
|
| |
