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Conserved domains on  [gi|1831517056|ref|NP_001367940|]
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Serpentine Receptor, class H [Caenorhabditis elegans]

Protein Classification

serpentine receptor domain-containing protein( domain architecture ID 27798)

serpentine receptor domain-containing protein which belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Srh super family cl11665
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 26-326 5.45e-25

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


The actual alignment was detected with superfamily member pfam10318:

Pssm-ID: 416353  Cd Length: 302  Bit Score: 102.62  E-value: 5.45e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831517056  26 YLISTLILPILTIPIYIEGIYCLYFSTDQLQQHYTSVLKNHVFLNFIGEIFGFYLMRPVVILPVVGLNSEGLLGYFNFHT 105
Cdd:pfam10318   6 LSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSYLGVPT 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831517056 106 FFQLILVFLLYQVNACTMIHLLIIRLKSVLPITFQYYKLSIRFGHLFVYgtYISSVCSLSNFALLYENQDNAKFFWYKLL 185
Cdd:pfam10318  86 PIQFYIGVTSLALVGVSIILLFENRYSILFTNKKRITWKKTRVLYLIFN--YIIALLFLIPIYLNIPDQEAAKLKVLKKL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831517056 186 aGNMPARFW-SESYVVASGSYFRFSLFLKLCSISLFLYIIacIFIPVVAFQILNRMKHRLSRHVVQAQKMSIKALLFQIS 264
Cdd:pfam10318 164 -PCLPPEFFdNPPVFVLAIDSTYFLICIVLLILILIIQIL--FFVFLTIYYLFKSVKSSLSKKTRKLQKKFFIALIIQVS 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1831517056 265 IIVSFLLFPFSTFIVGLEMRVNNPLVVAISLTFAMVHGAAATLAMIIANKPHRTIFLSHLKY 326
Cdd:pfam10318 241 IPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFKK 302
 
Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 26-326 5.45e-25

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 102.62  E-value: 5.45e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831517056  26 YLISTLILPILTIPIYIEGIYCLYFSTDQLQQHYTSVLKNHVFLNFIGEIFGFYLMRPVVILPVVGLNSEGLLGYFNFHT 105
Cdd:pfam10318   6 LSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSYLGVPT 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831517056 106 FFQLILVFLLYQVNACTMIHLLIIRLKSVLPITFQYYKLSIRFGHLFVYgtYISSVCSLSNFALLYENQDNAKFFWYKLL 185
Cdd:pfam10318  86 PIQFYIGVTSLALVGVSIILLFENRYSILFTNKKRITWKKTRVLYLIFN--YIIALLFLIPIYLNIPDQEAAKLKVLKKL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831517056 186 aGNMPARFW-SESYVVASGSYFRFSLFLKLCSISLFLYIIacIFIPVVAFQILNRMKHRLSRHVVQAQKMSIKALLFQIS 264
Cdd:pfam10318 164 -PCLPPEFFdNPPVFVLAIDSTYFLICIVLLILILIIQIL--FFVFLTIYYLFKSVKSSLSKKTRKLQKKFFIALIIQVS 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1831517056 265 IIVSFLLFPFSTFIVGLEMRVNNPLVVAISLTFAMVHGAAATLAMIIANKPHRTIFLSHLKY 326
Cdd:pfam10318 241 IPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFKK 302
 
Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 26-326 5.45e-25

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 102.62  E-value: 5.45e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831517056  26 YLISTLILPILTIPIYIEGIYCLYFSTDQLQQHYTSVLKNHVFLNFIGEIFGFYLMRPVVILPVVGLNSEGLLGYFNFHT 105
Cdd:pfam10318   6 LSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSYLGVPT 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831517056 106 FFQLILVFLLYQVNACTMIHLLIIRLKSVLPITFQYYKLSIRFGHLFVYgtYISSVCSLSNFALLYENQDNAKFFWYKLL 185
Cdd:pfam10318  86 PIQFYIGVTSLALVGVSIILLFENRYSILFTNKKRITWKKTRVLYLIFN--YIIALLFLIPIYLNIPDQEAAKLKVLKKL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831517056 186 aGNMPARFW-SESYVVASGSYFRFSLFLKLCSISLFLYIIacIFIPVVAFQILNRMKHRLSRHVVQAQKMSIKALLFQIS 264
Cdd:pfam10318 164 -PCLPPEFFdNPPVFVLAIDSTYFLICIVLLILILIIQIL--FFVFLTIYYLFKSVKSSLSKKTRKLQKKFFIALIIQVS 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1831517056 265 IIVSFLLFPFSTFIVGLEMRVNNPLVVAISLTFAMVHGAAATLAMIIANKPHRTIFLSHLKY 326
Cdd:pfam10318 241 IPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFKK 302
7TM_GPCR_Sri pfam10327
Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis ...
 68-320 4.98e-03

Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Sri is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 313539  Cd Length: 303  Bit Score: 38.30  E-value: 4.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831517056  68 FLNFIGEIFGFYLMRPVVILPVVGLNSEGLLG-YFNFHTFFQL-ILVFLLYQVNACTMI-----HLLIIRLKSVLPITFQ 140
Cdd:pfam10327  52 ISCTLTDIHLTFLMQPIPLFPIIAGYCNGFLAtVFGISSHYLMtIFVFLLSFQLESLLLcfvrkHQAIAKILSKHVIPKW 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831517056 141 YYKLSIRFGHLFVYGTYISsvcsLSNFALLYENQdnakffwYKLLAGNMP---ARFWSESYVVASGSYFRFSLFLKLCSI 217
Cdd:pfam10327 132 LYIFLYILCHIFPFLTAFL----FYQSGLSREEQ-------LEYVKENYPeylSQFSSLPNFAIYDYNPWLIVFGILAIF 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831517056 218 SLFLYIIACIFIPVVAFQILNRMKHRLSRHVVQAQKMSIKALLFQISIIVSFLLFPFSTFIVGLEMRVNNPLVVAISLTF 297
Cdd:pfam10327 201 GGSLSFLILVYLTVDMFRMLKRLRKKISAQTYQKHRAALRSLIAQFATSPVCILPPFAFVVVVLFPIEYSQEISEILLAI 280

                         250       260
                  ....*....|....*....|...
gi 1831517056 298 AMVHGAAATLAMIIANKPHRTIF 320
Cdd:pfam10327 281 FSTHSSVNSIVLILTTPPYRKFL 303
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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