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Conserved domains on  [gi|1831510044|ref|NP_001367648|]
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TOG domain-containing protein [Caenorhabditis elegans]

Protein Classification

HEAT repeat domain-containing protein( domain architecture ID 10607647)

HEAT repeat domain-containing protein similar to Saccharomyces cerevisiae importin subunit beta-2, also called karyopherin-104, that functions as a nuclear transport receptor for arginine/glycine-rich nuclear localization signals (rg-NLS) and PY-NLS in cargo substrates

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 1480-1534 2.77e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


:

Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 38.12  E-value: 2.77e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1831510044 1480 WRTKCAATELLGSMAFCAPRQLSACLPNIVPKLIEILADSSSKVQKSGEKALQQI 1534
Cdd:pfam13513    1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
HSH155 super family cl26678
U2 snRNP spliceosome subunit [RNA processing and modification];
1934-2054 4.93e-03

U2 snRNP spliceosome subunit [RNA processing and modification];


The actual alignment was detected with superfamily member COG5181:

Pssm-ID: 227508 [Multi-domain]  Cd Length: 975  Bit Score: 42.24  E-value: 4.93e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510044 1934 INDILPVLDA---NQKSEEvAKRVGVAIAlhEIIGNMSKEVTNHYLGAIVAPVRRAICDESELVREAAADTFTVLYHVV- 2009
Cdd:COG5181    314 VEELLPFLEAlcgSRKSWE-ARHTGIRIA--QQICELLGRSRLSHLGPLLKCISKLLKDRSRFVRIDTANALSYLAELVg 390

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1831510044 2010 --GNEALDEIICPLLEQLTPEQDHILAGLCDVMrqnsRSMLPYLLPK 2054
Cdd:COG5181    391 pyGIEQFDEVLCPLWEGASQHRGKELVSFLKAM----GFIIPLMSPE 433
 
Name Accession Description Interval E-value
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 1480-1534 2.77e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 38.12  E-value: 2.77e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1831510044 1480 WRTKCAATELLGSMAFCAPRQLSACLPNIVPKLIEILADSSSKVQKSGEKALQQI 1534
Cdd:pfam13513    1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
HSH155 COG5181
U2 snRNP spliceosome subunit [RNA processing and modification];
1934-2054 4.93e-03

U2 snRNP spliceosome subunit [RNA processing and modification];


Pssm-ID: 227508 [Multi-domain]  Cd Length: 975  Bit Score: 42.24  E-value: 4.93e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510044 1934 INDILPVLDA---NQKSEEvAKRVGVAIAlhEIIGNMSKEVTNHYLGAIVAPVRRAICDESELVREAAADTFTVLYHVV- 2009
Cdd:COG5181    314 VEELLPFLEAlcgSRKSWE-ARHTGIRIA--QQICELLGRSRLSHLGPLLKCISKLLKDRSRFVRIDTANALSYLAELVg 390

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1831510044 2010 --GNEALDEIICPLLEQLTPEQDHILAGLCDVMrqnsRSMLPYLLPK 2054
Cdd:COG5181    391 pyGIEQFDEVLCPLWEGASQHRGKELVSFLKAM----GFIIPLMSPE 433
HEAT COG1413
HEAT repeat [General function prediction only];
1428-1535 7.49e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 39.23  E-value: 7.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510044 1428 KALPSLLITFGDTDSNVRQSAedtARAMMAsmtvYGTKLVLPVLIVAIDDDSWRTKCAATELLGSMAfcaprqlsacLPN 1507
Cdd:COG1413     47 RAVPALLEALKDPDPEVRAAA---AEALGR----IGDPEAVPALIAALKDEDPEVRRAAAEALGRLG----------DPA 109

                           90       100
                   ....*....|....*....|....*...
gi 1831510044 1508 IVPKLIEILADSSSKVQKSGEKALQQIA 1535
Cdd:COG1413    110 AVPALLEALKDPDWEVRRAAARALGRLG 137
 
Name Accession Description Interval E-value
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 1480-1534 2.77e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 38.12  E-value: 2.77e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1831510044 1480 WRTKCAATELLGSMAFCAPRQLSACLPNIVPKLIEILADSSSKVQKSGEKALQQI 1534
Cdd:pfam13513    1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
HSH155 COG5181
U2 snRNP spliceosome subunit [RNA processing and modification];
1934-2054 4.93e-03

U2 snRNP spliceosome subunit [RNA processing and modification];


Pssm-ID: 227508 [Multi-domain]  Cd Length: 975  Bit Score: 42.24  E-value: 4.93e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510044 1934 INDILPVLDA---NQKSEEvAKRVGVAIAlhEIIGNMSKEVTNHYLGAIVAPVRRAICDESELVREAAADTFTVLYHVV- 2009
Cdd:COG5181    314 VEELLPFLEAlcgSRKSWE-ARHTGIRIA--QQICELLGRSRLSHLGPLLKCISKLLKDRSRFVRIDTANALSYLAELVg 390

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1831510044 2010 --GNEALDEIICPLLEQLTPEQDHILAGLCDVMrqnsRSMLPYLLPK 2054
Cdd:COG5181    391 pyGIEQFDEVLCPLWEGASQHRGKELVSFLKAM----GFIIPLMSPE 433
HEAT COG1413
HEAT repeat [General function prediction only];
1428-1535 7.49e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 39.23  E-value: 7.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510044 1428 KALPSLLITFGDTDSNVRQSAedtARAMMAsmtvYGTKLVLPVLIVAIDDDSWRTKCAATELLGSMAfcaprqlsacLPN 1507
Cdd:COG1413     47 RAVPALLEALKDPDPEVRAAA---AEALGR----IGDPEAVPALIAALKDEDPEVRRAAAEALGRLG----------DPA 109

                           90       100
                   ....*....|....*....|....*...
gi 1831510044 1508 IVPKLIEILADSSSKVQKSGEKALQQIA 1535
Cdd:COG1413    110 AVPALLEALKDPDWEVRRAAARALGRLG 137
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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