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Conserved domains on  [gi|1831508387|ref|NP_001367331|]
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Putative transporter B0252.3 [Caenorhabditis elegans]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 1-267 1.85e-64

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17317:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 331  Bit Score: 205.51  E-value: 1.85e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387   1 MWVVGACFLGLLAYILPDWRYLMFCISVPNIFVALLIYMTvpeslhflvssqqnekieawlekirgpkgdisasdivedr 80
Cdd:cd17317   122 FWALGYMLLALLAYLIRDWRWLQLAISLPGLLFLLLLWWL---------------------------------------- 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387  81 dengssfktlcremwkhkmfIVYVLVMTYIWIVDTFIYFGLAFYSTNLAGNLYLNFVLMSLVEAPAYIFSPIFMNKYGRK 160
Cdd:cd17317   162 --------------------PRRTIIVGLIWFVTSLVYYGLSLNSSNLGGNLYLNFFLSGLVEIPAYFLALLLLDRLGRR 221

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387 161 VLISGTHIIAGLSFLGIVLSSEAWH---IHFWLLGKFAISCSFMSIYMFASEIFPTDGRNKCIGFCETLSRFGGMLSPYL 237
Cdd:cd17317   222 WTLSGSLLLAGLACLVTALLPDDENtlaLTLALVGKFAISAAFSVIYLYTAELYPTVVRNTGVGLCSTVARVGAILAPFI 301

                         250       260       270
                  ....*....|....*....|....*....|
gi 1831508387 238 SHLTAVHALAPAITLSLIAVSGGLLTLILP 267
Cdd:cd17317   302 VLLGKIGPLLPLIIFGVLALLGGLLTLLLP 331
 
Name Accession Description Interval E-value
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 1-267 1.85e-64

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 205.51  E-value: 1.85e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387   1 MWVVGACFLGLLAYILPDWRYLMFCISVPNIFVALLIYMTvpeslhflvssqqnekieawlekirgpkgdisasdivedr 80
Cdd:cd17317   122 FWALGYMLLALLAYLIRDWRWLQLAISLPGLLFLLLLWWL---------------------------------------- 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387  81 dengssfktlcremwkhkmfIVYVLVMTYIWIVDTFIYFGLAFYSTNLAGNLYLNFVLMSLVEAPAYIFSPIFMNKYGRK 160
Cdd:cd17317   162 --------------------PRRTIIVGLIWFVTSLVYYGLSLNSSNLGGNLYLNFFLSGLVEIPAYFLALLLLDRLGRR 221

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387 161 VLISGTHIIAGLSFLGIVLSSEAWH---IHFWLLGKFAISCSFMSIYMFASEIFPTDGRNKCIGFCETLSRFGGMLSPYL 237
Cdd:cd17317   222 WTLSGSLLLAGLACLVTALLPDDENtlaLTLALVGKFAISAAFSVIYLYTAELYPTVVRNTGVGLCSTVARVGAILAPFI 301

                         250       260       270
                  ....*....|....*....|....*....|
gi 1831508387 238 SHLTAVHALAPAITLSLIAVSGGLLTLILP 267
Cdd:cd17317   302 VLLGKIGPLLPLIIFGVLALLGGLLTLLLP 331
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 2-277 1.16e-49

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 171.74  E-value: 1.16e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387   2 WVVGACFLGLLAYILPDWRYLMFCISVPNiFVALLIYMTVPESLHFLVSSQQNEKIEAWLEKIR---GPKGDISASDIVE 78
Cdd:TIGR00898 225 FSLGLVLLPLVAYFIPDWRWLQLAVSLPT-FLFFLLSWFVPESPRWLISQGRIEEALKILQRIAkinGKKLPAEVLSLSL 303

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387  79 DRDENGS----SFKTLCREMWKHKMFIvyvLVMtYIWIVDTFIYFGLAFYSTNLAGNLYLNFVLMSLVEAPAYIFSPIFM 154
Cdd:TIGR00898 304 EKDLSSSkkqySFLDLFRTPNLRKTTL---CLM-MLWFTTAFSYYGLVLDLGNLGGNIYLDLFISGLVELPAKLITLLLI 379

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387 155 NKYGRKVLISGTHIIAGLSFLGIVLSSEawHIHFW-----LLGKFAISCSFMSIYMFASEIFPTDGRNKCIGFCETLSRF 229
Cdd:TIGR00898 380 DRLGRRYTMAASLLLAGVALLLLLFVPV--DLYFLrtalaVLGKFGITSAFQMVYLYTAELYPTVVRNLGVGVCSTMARV 457

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1831508387 230 GGMLSPYLSHLTAVHALAPAITLSLIAVSGGLLTLILPETLNTKLPST 277
Cdd:TIGR00898 458 GSIISPFLVYLGEKWLFLPLVLFGGLALLAGILTLFLPETKGVPLPET 505
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
99-267 7.27e-06

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 46.79  E-value: 7.27e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387  99 MFIVYVLVMTYIWIVDTFI--YFGLAF-YSTNLAGNLYLnfvLMSLVEAPAYIFSPIFMNKYGR--KVLISGTHIIAGLS 173
Cdd:COG2271   185 LALAYFLVYFALYGFLTWLptYLVEVRgLSLAQAGLLLS---LPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALA 261

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387 174 FLGIVLSSEAWHIHFWL-LGKFAISCSFMSIYMFASEIFPTDGRNKCIGFCETLSRFGGMLSPYLS-HLTAVHALAPA-I 250
Cdd:COG2271   262 LLLLALLPSPALAIALLfLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVgYLLDATGYQAAfL 341

                         170
                  ....*....|....*..
gi 1831508387 251 TLSLIAVSGGLLTLILP 267
Cdd:COG2271   342 LLAALALLAALLALLLL 358
Sugar_tr pfam00083
Sugar (and other) transporter;
3-223 1.27e-05

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 46.11  E-value: 1.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387   3 VVGACFLGLLAYILPD--WRYLMFCISVPNIFVALLIyMTVPESLHFLVSSQQNEKIEAWLEKIRGPKG-DISASDIVED 79
Cdd:pfam00083 152 LLAYIFGLGLNKTSNSdgWRIPLGLQLVPALLLIIGL-LFLPESPRWLVEKGRLEEAREVLAKLRGVPDvDRELDEIKDS 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387  80 RDENGSSFKTLCREMW--KHKMFIVYVLVMTYIWI----VDTFIYFGLAFYSTNLAGNLYLNFVLMSLVEAPAYIFSPIF 153
Cdd:pfam00083 231 LEAGQEAEKASWKELFstKTRRQRLLIGVMLQIFQqltgINAIFYYSTTIFENLGLSDSFLVTIIVGVVNFVFTFIAIFL 310

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387 154 MNKYGRK--VLISGTHIIAGLSFLGIV----LSSEAWH----IHFWLLGKFAISCSFMSI-YMFASEIFPTDGRNKCIGF 222
Cdd:pfam00083 311 VDRFGRRplLLLGAAGMAICFVILGIVallgVSKSDWAgivaIVFIALFIAFFAMGWGPVpWVIVSELFPLSVRSKAMAL 390


                  .
gi 1831508387 223 C 223
Cdd:pfam00083 391 A 391
 
Name Accession Description Interval E-value
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 1-267 1.85e-64

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 205.51  E-value: 1.85e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387   1 MWVVGACFLGLLAYILPDWRYLMFCISVPNIFVALLIYMTvpeslhflvssqqnekieawlekirgpkgdisasdivedr 80
Cdd:cd17317   122 FWALGYMLLALLAYLIRDWRWLQLAISLPGLLFLLLLWWL---------------------------------------- 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387  81 dengssfktlcremwkhkmfIVYVLVMTYIWIVDTFIYFGLAFYSTNLAGNLYLNFVLMSLVEAPAYIFSPIFMNKYGRK 160
Cdd:cd17317   162 --------------------PRRTIIVGLIWFVTSLVYYGLSLNSSNLGGNLYLNFFLSGLVEIPAYFLALLLLDRLGRR 221

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387 161 VLISGTHIIAGLSFLGIVLSSEAWH---IHFWLLGKFAISCSFMSIYMFASEIFPTDGRNKCIGFCETLSRFGGMLSPYL 237
Cdd:cd17317   222 WTLSGSLLLAGLACLVTALLPDDENtlaLTLALVGKFAISAAFSVIYLYTAELYPTVVRNTGVGLCSTVARVGAILAPFI 301

                         250       260       270
                  ....*....|....*....|....*....|
gi 1831508387 238 SHLTAVHALAPAITLSLIAVSGGLLTLILP 267
Cdd:cd17317   302 VLLGKIGPLLPLIIFGVLALLGGLLTLLLP 331
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 2-277 1.16e-49

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 171.74  E-value: 1.16e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387   2 WVVGACFLGLLAYILPDWRYLMFCISVPNiFVALLIYMTVPESLHFLVSSQQNEKIEAWLEKIR---GPKGDISASDIVE 78
Cdd:TIGR00898 225 FSLGLVLLPLVAYFIPDWRWLQLAVSLPT-FLFFLLSWFVPESPRWLISQGRIEEALKILQRIAkinGKKLPAEVLSLSL 303

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387  79 DRDENGS----SFKTLCREMWKHKMFIvyvLVMtYIWIVDTFIYFGLAFYSTNLAGNLYLNFVLMSLVEAPAYIFSPIFM 154
Cdd:TIGR00898 304 EKDLSSSkkqySFLDLFRTPNLRKTTL---CLM-MLWFTTAFSYYGLVLDLGNLGGNIYLDLFISGLVELPAKLITLLLI 379

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387 155 NKYGRKVLISGTHIIAGLSFLGIVLSSEawHIHFW-----LLGKFAISCSFMSIYMFASEIFPTDGRNKCIGFCETLSRF 229
Cdd:TIGR00898 380 DRLGRRYTMAASLLLAGVALLLLLFVPV--DLYFLrtalaVLGKFGITSAFQMVYLYTAELYPTVVRNLGVGVCSTMARV 457

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1831508387 230 GGMLSPYLSHLTAVHALAPAITLSLIAVSGGLLTLILPETLNTKLPST 277
Cdd:TIGR00898 458 GSIISPFLVYLGEKWLFLPLVLFGGLALLAGILTLFLPETKGVPLPET 505
MFS_SLC22A15 cd17377
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ...
 105-267 7.30e-28

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340935 [Multi-domain]  Cd Length: 353  Bit Score: 110.25  E-value: 7.30e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387 105 LVMTYIWIVDTFIYFGLAFYSTNLAGNLYLNFVLMSLVEAPAYIFSPIFMNK--YGRKVLISGTHIIAGLSFLGIVLSSE 182
Cdd:cd17377   180 LILMYVWFVCSLVYYGLTLNAGDLGGNIYLNLALSGLVELPAYPLCIYLINQkwSGRRRTLAGFLFLGGIACLLVMFVPE 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387 183 AWHIHFW---------LLGKFAISCSFMSIYMFASEIFPTDGRNKCIGFCETLSRFGGMLSPYLSHLTAVHALAPAITLS 253
Cdd:cd17377   260 KKDSGVFavvnstslsLLGKLTISAAFNIVYIYTSELYPTVVRNAGLGVCSMFSRVGGIIAPFIPSLKSVQWSLPFIVFG 339

                         170
                  ....*....|....
gi 1831508387 254 LIAVSGGLLTLILP 267
Cdd:cd17377   340 ASGLSAGLLSLLLP 353
MFS_SLC22A4_5_OCTN1_2 cd17376
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 ...
 90-267 5.41e-24

Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 and 2) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 22 members 4 (SLC22A4) and 5 (SLC22A5), and similar proteins. SLC22A4 is also called ergothioneine transporter (ETT) or organic cation/carnitine transporter 1 (OCTN1). It is a sodium-ion dependent, low affinity carnitine transporter, and a highly specific transporter for the uptake of ergothioneine (ET), a thiolated derivative of histidine with antioxidant properties. ET is a natural compound produced only by certain fungi and bacteria and must be absorbed from the diet by humans and other vetebrates. SLC22A5, also called organic cation/carnitine transporter 2 (OCTN2), is a sodium-ion dependent, high affinity carnitine transporter involved in the active cellular uptake of carnitine. SLC22A4/5 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340934 [Multi-domain]  Cd Length: 342  Bit Score: 99.46  E-value: 5.41e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387  90 LCREMWkhkMFIVYVLVMT-YIWIVDTFIYFGLAFYSTNLAGNLYLNFVLMSLVEAPAYIFSPIFMNKYGRKVLISGTHI 168
Cdd:cd17376   164 LCVPLW---WFIPITTIMSlLLWMAISVGYFGLSLNTPNLHGDPYLNCFLSAVIEVPAYIIAWLLLRSLPRRYSIAATLV 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387 169 IAGLSFLGIVLSSEAWH---IHFWLLGKFAISCSFMSIYMFASEIFPTDGRNKCIGFCETLSRFGGMLSPYLSHLTAVHA 245
Cdd:cd17376   241 LGGGVLLFIQLVPTDLQvlaTALVMLGKFGITAAFSMVYVYTAELYPTVVRNMGVGVCSTASRIGSIISPYFVYLGAYDR 320

                         170       180
                  ....*....|....*....|..
gi 1831508387 246 LAPAITLSLIAVSGGLLTLILP 267
Cdd:cd17376   321 YLPYILMGSLTVLIGILTLFLP 342
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 2-267 7.88e-22

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 93.51  E-value: 7.88e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387   2 WVVGACFLGLLAYILPDWRYLMFCISVPNIFVALLIYmtvpeslhflvssqqnekieaWLEKIrgpkgdisasdivedrd 81
Cdd:cd17374   133 FSIGQMLLAGLAYAIRDWRLLQLVVSVPFFLFFLYSW---------------------WLPKR----------------- 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387  82 engssfktlcremwkhkmfivyVLVMTYIWIVDTFIYFGLAFYSTNLAGNLYLNFVLMSLVEAPAYIFSPIFMNKYGRKV 161
Cdd:cd17374   175 ----------------------TLILSFVWFANSFSYYGLSLDLQHLGLNVFLLQFLFGAVEVPARCLALFLLNHMGRRI 232

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387 162 LISGTHIIAGLSFLGIVLSSE---AWHIHFWLLGKFAISCSFMSIYMFASEIFPTDGRNKCIGFCETLSRFGGMLSPYLS 238
Cdd:cd17374   233 SQAVLLLLAGLCILANIFVPQemqTLRTVLAVLGKGSSAAAFTISYVYTAELFPTVLRQTGMGLNSMFARIGGILAPLIM 312

                         250       260
                  ....*....|....*....|....*....
gi 1831508387 239 HLTAVHALAPAITLSLIAVSGGLLTLILP 267
Cdd:cd17374   313 LLGVYSPLLPMIIYGVLPILAGLLALLLP 341
MFS_SLC22A16_CT2 cd17375
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major ...
 110-267 2.88e-20

Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 16 (SLC22A16) is also called carnitine transporter 2 (CT2), fly-like putative transporter 2 (FLIPT2), organic cation transporter OKB1, or organic cation/carnitine transporter 6 (OCT6). It is a partially sodium-ion dependent high affinity carnitine transporter. It also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. It is one of several organic cation transporters (OCTs) that falls into the SLC22 (solute carrier 22) family. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. SLC22A16 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340933 [Multi-domain]  Cd Length: 341  Bit Score: 89.04  E-value: 2.88e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387 110 IWIVDTFIYFGLAFYSTNLAGNLYLNFVLMSLVEAPAYIFSPIFMNKYGRKVLISGTHIIAGLS-FLGIVLSS--EAWHI 186
Cdd:cd17375   181 IWFTGSLGYYVFSLGSVNLGGNEYLNLFLVGAVEIPSYIIACIGMDKLGRRNTLAPFLLLSALAcMLIMVIPQdyEVLTI 260

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387 187 HFWLLGKFAISCSFMSIYMFASEIFPTDGRNKCIGFCETLSRFGGMLSPYLSHLTAVHALAPAITLSLIAVSGGLLTLIL 266
Cdd:cd17375   261 VLSMTGKFAIAIAFGLIYLYTAELYPTIVRSLAVGSGSMMCRVGSVVAPFCVYLSDVWIFLPQLLVGIMAFLSGILTLML 340


                  .
gi 1831508387 267 P 267
Cdd:cd17375   341 P 341
MFS_OCT_plant cd17378
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ...
 100-267 3.48e-20

Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340936 [Multi-domain]  Cd Length: 342  Bit Score: 88.96  E-value: 3.48e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387 100 FIVYVLVMTYIWIVDTFIYFGLAFYSTNLAGNLYLNFVLMSLVEAPAYIFSPIFMNKYGRKVLISGTHIIAGLS-FLGIV 178
Cdd:cd17378   171 FARRLLAVMVIGFGIGMVYYGIPLAVGNLKFNIYLSVALNALSELPAFVITAFLLDRFGRRPSLLGFTLLSGAScLLCFV 250

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387 179 LS---SEAWHIHFWLLGKFAISCSFMSIYMFASEIFPTDGRNKCIGFCETLSRFGGMLSPYLSHLTAVHALAPAITLSLI 255
Cdd:cd17378   251 LSiggTTSLQIALELVGFFGAAGAFNLLYIYTVELFPTCVRNAALGMLRQALVVGGIFAPFIVSLGRKNAALSFGVFGVA 330

                         170
                  ....*....|..
gi 1831508387 256 AVSGGLLTLILP 267
Cdd:cd17378   331 ILLLGLFALGLP 342
MFS_SLC22A6_OAT1_like cd17446
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ...
 2-267 1.63e-17

Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341004 [Multi-domain]  Cd Length: 339  Bit Score: 81.31  E-value: 1.63e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387   2 WVVGACFLGLLAYILPDWRYLMFCISVPniFVALLIYmtvpeslhflvssqqnekiEAWLEKIrgpkgdisasdivedrd 81
Cdd:cd17446   131 YTLGQLILAGVAYAIRDWRWLQLAVSLP--FFIFFLY-------------------SWWFPRI----------------- 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387  82 engssfkTLCremwkhkmfivyvlvMTYIWIVDTFIYFGLAFYSTNLAGNLYLNFVLMSLVEAPAYIFSPIFMNKYGRKV 161
Cdd:cd17446   173 -------TFC---------------LSLVWFSTSFAYYGLAMDLQKFGVSIYLIQIIFGAVDIPAKFISTLTMSYLGRRP 230

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387 162 LISGTHIIAGLSFLGIVLSSEAWHI---HFWLLGKFAISCSFMSIYMFASEIFPTDGRNKCIGFCETLSRFGGMLSPYLS 238
Cdd:cd17446   231 TQAAALILAGIMILANIFVPQDLQTvrtALAVFGKGCLAASFNCVYLYTGELYPTVIRQTGMGLGSTMARLGGIVAPLVK 310

                         250       260
                  ....*....|....*....|....*....
gi 1831508387 239 HLTAVHALAPAITLSLIAVSGGLLTLILP 267
Cdd:cd17446   311 MLGEYYPFLPLIIYGAAPILSGIAACFLP 339
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
 4-267 2.51e-17

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 80.86  E-value: 2.51e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387   4 VGACFLGLLAYILPDWRYLMFCISVPNiFVALLIYMTVPEslhflvssqqnekieawlekirgpkgdisasdivedrden 83
Cdd:cd17379   133 LGLLILPGIAYFIPHWRWLQLAVTLPN-FLFLLYYWFIPK---------------------------------------- 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387  84 gssfktlcremwkhkmfivYVLVMTYIWIVDTFIYFGLAFYSTNLAGNLYLNFVLMSLVEAPAYIFSPIFMNKYGRKVLI 163
Cdd:cd17379   172 -------------------HTFILMYAWFTSAVVYQGLIMRLGITGGNLYLDFFISALVELPAAFIILLTIDRIGRRLPF 232

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387 164 SGTHIIAGLSFLGIVLSSEAWHihfWL------LGKFAISCSFMSIYMFASEIFPTDGRNKCIGFCETLSRFGGMLSPYL 237
Cdd:cd17379   233 AASNIVAGAACLITAFIPPDLH---WLkttiacVGRLGITMAFEIVCLVNTELYPTFLRNLGVSVCSSLCDIGGIIAPFL 309

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1831508387 238 SH-LTAVHALAPAITLSLIAVSGGLLTLILP 267
Cdd:cd17379   310 LYrLAEIWLELPLIVFGVLALVAGGLVLLLP 340
MFS_SLC22A7_OAT2 cd17447
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ...
 2-267 3.29e-17

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341005 [Multi-domain]  Cd Length: 341  Bit Score: 80.54  E-value: 3.29e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387   2 WVVGACFLGLLAYILPDWRYLMFCISVPNIFVALLIYmtvpeslhflvssqqnekieaWLEKIrgpkgdisasdivedrd 81
Cdd:cd17447   133 WTVGNMLLALVAYLIRDWRWLILAVTLPCAPGIITWW---------------------WVPKI----------------- 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387  82 engssfktlcremwkhkmfivyVLVMTYIWIVDTFIYFGLAFYSTNLAGNLYLNFVLMSLVEAPAYIFSPIFMNKYGRKV 161
Cdd:cd17447   175 ----------------------SLCTGIVWFGVAFTYYGISFNISGFGLNVYLTQFIYGAIELPAKLLAYLLLDRIGRRL 232

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387 162 LISGTHIIAGLSF-LGIVLSSEAWHIH--FWLLGKFAISCSFMSIYMFASEIFPTDGRNKCIGFCETLSRFGGMLSPYLS 238
Cdd:cd17447   233 TQAGSLILTGLSIgINILIPSEFTVVRtvIAVLGKGFSEAAFTTVFLYTSELYPTVLRQNGMGYTSFIARLGGSLAPLVI 312

                         250       260
                  ....*....|....*....|....*....
gi 1831508387 239 HLTAVHALAPAITLSLIAVSGGLLTLILP 267
Cdd:cd17447   313 LLDDVWLSLPQVIFCGVALLAGGVAFLLP 341
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
 133-269 7.48e-09

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 56.52  E-value: 7.48e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387 133 YLNFvLMSLVEAPAYIFSPIFMNKYGRKVLISGTHIIAGLS--FLGIVLSSEAWHIHFWLLGKFAIScSFMSIYMFASEI 210
Cdd:TIGR01299 599 FVNF-LGTLAVLPGNIVSALLMDKIGRLRMLAGSMVLSCIScfFLSFGNSESAMIALLCLFGGLSIA-AWNALDVLTVEL 676

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387 211 FPTDGRNKCIGFCETLSRFGGMLSPYL-SHLTAVHALAPAITLSLIAVSGGLLTLILPET 269
Cdd:TIGR01299 677 YPSDKRATAFGFLNALCKAAAVLGILIfGSFVGITKAAPILFASAALACGGLLALKLPDT 736
MFS_SV2 cd17363
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ...
 132-269 8.71e-09

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340921 [Multi-domain]  Cd Length: 474  Bit Score: 55.96  E-value: 8.71e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387 132 LYLNFVLMSLVEAPAYIFSPIFMNKYGRKVLISGTHIIAGLSFLGIVLSSEAWHIHFWLLGKFAIS-CSFMSIYMFASEI 210
Cdd:cd17363   334 IYLVSFLGSLSVLPGNIVSALLMDKIGRLKMIGGSMLLSAVCCFFLFFGNSESAMIGLQCLFCGVSiAAWNALDVVTVEL 413

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387 211 FPTDGRNKCIGFCETLSRFGGMLSPYL-SHLTAVHALAPAITLSLIAVSGGLLTLILPET 269
Cdd:cd17363   414 YPTDKRATAFGFLNGLCKLAAILGNSIfGSFVGITKVIPILLASAALVCGGLLALKLPET 473
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 104-264 1.23e-07

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 52.22  E-value: 1.23e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387 104 VLVMTYIWIVDTFIYFGLAFYSTNL--------AGNLYLNFVLMSLVEAPAYIFSPIFMNKYGRKVLISGTHIIAGLS-- 173
Cdd:cd17316   179 TLLLILLWFFISFGYYGLTTFLPTYlqtvlglsPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILal 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387 174 FLGIVLSSEAWHIHFWLLGKFAISCSFMSIYM-FASEIFPTDGRNKCIGFCETLSRFGGMLSPYLSHLTAVHA---LAPA 249
Cdd:cd17316   259 PLFYLLSGSPTLLLLLLFILSFFVGGVWGALYaYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTggtGVPA 338

                         170
                  ....*....|....*
gi 1831508387 250 ITLSLIAVSGGLLTL 264
Cdd:cd17316   339 LILALLAIVALIVAL 353
MFS_SV2C cd17440
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ...
 133-269 4.04e-07

Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340998 [Multi-domain]  Cd Length: 479  Bit Score: 51.07  E-value: 4.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387 133 YLNFvLMSLVEAPAYIFSPIFMNKYGRKVLISGTHIIAGLS-FLGIVLSSEAWHIHFWLLGKFAISCSFMSIYMFASEIF 211
Cdd:cd17440   341 FVNF-LGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGIScFFLWFGTSESMMIGMLCLYNGLTISAWNSLDVVTVELY 419

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1831508387 212 PTDGRNKCIGFCETLSRFGGMLSPYL-SHLTAVHALAPAITLSLIAVSGGLLTLILPET 269
Cdd:cd17440   420 PTDRRATGFGFLNALCKAAAVLGNLIfGSLVGITKAIPILLASTVLVCGGLVGLRLPDT 478
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 19-269 6.53e-07

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 50.34  E-value: 6.53e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387  19 WRYLMFCISVPNIFVALLIYmTVPESLHFLVSSQQN-EKIEAWLEKIRGPKGDISAS---DIVEDRDENGSSFKTLC--- 91
Cdd:cd17357   172 WPYLLFFPGIPALLQLAALP-FFPESPKFLLISKGDeEEAEKSLKFLRGIEDDVDQEleeIKKESEQMGDQKQVSLMqll 250

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387  92 --REMWKHKMFIVYVLVM------TYIWIVDTFIyFGLAFYSTNLAgnLYLNFvLMSLVEAPAYIFSPIFMNKYGRK--V 161
Cdd:cd17357   251 rdPSLRLPLLLVLVVSASqqfsgiNAIFFYSTFI-FENAGFSPQLA--EWANL-GIGIVNVLSTIVGPFLIEKVGRRplL 326

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387 162 LISGTHIIAGLSFLGIVL-SSEAWHIhfwlLGKFAISCSFMSIYMFA-----------SEIFPTDGRNKCI---GFCETL 226
Cdd:cd17357   327 LISLSVCAVALLLMSVFLfLSEQNSW----MSYGCIVAIFLFIFFFAiglgpipwfigAELFPQAPRSAAQslgSSVNWT 402

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1831508387 227 SRF-GGMLSPYLSHLTAVHALAP-AITLSLIAVsggLLTLILPET 269
Cdd:cd17357   403 SNFiVGMAFPPLQSIGGGFVFIIfAIPCALFLL---YLYRYLPET 444
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
 132-269 1.00e-06

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 49.92  E-value: 1.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387 132 LYLNFVLMSLVEAPAYIFSPIFMNKYGRKVLISGTHIIAGL-SFLGIVLSSEAWHIHFWLLGKFAISCSFMSIYMFASEI 210
Cdd:cd17438   337 IYLVSFLGSLSVLPGNIISALLMDKIGRIKMIGGSMLISAVcCFFLFFGNSESAMIGWQCLFCGTSIAAWNALDVITVEL 416

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387 211 FPTDGRNKCIGFCETLSRFGGML-SPYLSHLTAVHALAPAITLSLIAVSGGLLTLILPET 269
Cdd:cd17438   417 YPTNKRATAFGILNGLCKFAAILgNSIFASFVGITKVIPILLASTALVGGGLISLRLPET 476
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
 105-238 1.38e-06

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 49.07  E-value: 1.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387 105 LVMTYIWIVDTFIYFGLAFYSTNL--AGNL-------------------------YLNFVLMSLVEAPAYIFSPIFMNKY 157
Cdd:cd17372   177 LLLWVIWFGNAFAYYGVVLLTTELnnSHNVcgsksdsdsgesptekqcrnsndvdYRDVFIATFAEFPGLLISAAMIDRL 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387 158 GRKVLISGTHIIAGLSFLGIVL-SSEAWHIHFWLLGKFAISCSFMSIYMFASEIFPTDGRNKCIGFCETLSRFGGMLSPY 236
Cdd:cd17372   257 GRKASMASMLFTCCIFLLLLLIcQSPFILTVLLFGGRACISAAFTVVYIYTPEVYPTAVRALGVGTGSSVGRIGAILCPF 336


                  ..
gi 1831508387 237 LS 238
Cdd:cd17372   337 IA 338
MFS_SVOPL cd17442
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ...
 149-240 4.34e-06

Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341000 [Multi-domain]  Cd Length: 375  Bit Score: 47.49  E-value: 4.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387 149 FSPIFMNKYGRKVLISGTHIIAGLSFLGI-VLSSEAWHIHFWLLGKFAISCSFMSIYMFASEIFPTDGRNKCIGFCETLS 227
Cdd:cd17442   255 LNILGINFLGRRLSLVITMGLTAIFFLLLnICTSSAGLTIFLFMLRALVSANFNTVYIYTAEVYPTTMRALGMGTSGSLC 334

                          90
                  ....*....|...
gi 1831508387 228 RFGGMLSPYLSHL 240
Cdd:cd17442   335 RIGAMVAPFISQV 347
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
99-267 7.27e-06

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 46.79  E-value: 7.27e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387  99 MFIVYVLVMTYIWIVDTFI--YFGLAF-YSTNLAGNLYLnfvLMSLVEAPAYIFSPIFMNKYGR--KVLISGTHIIAGLS 173
Cdd:COG2271   185 LALAYFLVYFALYGFLTWLptYLVEVRgLSLAQAGLLLS---LPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALA 261

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387 174 FLGIVLSSEAWHIHFWL-LGKFAISCSFMSIYMFASEIFPTDGRNKCIGFCETLSRFGGMLSPYLS-HLTAVHALAPA-I 250
Cdd:COG2271   262 LLLLALLPSPALAIALLfLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVgYLLDATGYQAAfL 341

                         170
                  ....*....|....*..
gi 1831508387 251 TLSLIAVSGGLLTLILP 267
Cdd:COG2271   342 LLAALALLAALLALLLL 358
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
2-234 8.07e-06

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 46.51  E-value: 8.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387   2 WVVGACFLGLLAYILpDWRYLMFCISVPNIFVALLIYMTVPESLHflvssqqnekieawlekirgpkgdisasdivedrd 81
Cdd:COG2814   147 PALGPLLGGLLADLF-GWRWVFLVNAVLALLALLLLLRLLPESRP----------------------------------- 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387  82 ENGSSFKTLCREMWKHKMFIVYVLVMTYIWIVDTFIYFGLAFYSTNLAG----NLYLNFVLMSLVEAPAYIFSPIFMNKY 157
Cdd:COG2814   191 AARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGlsasAAGLLLALFGLGGVLGALLAGRLADRF 270

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1831508387 158 GRKVLISGTHIIAGLSFLGIVLSSEAWHIHFWL-LGKFAISCSFMSIYMFASEIFPTDGRNKCIGFCETLSRFGGMLS 234
Cdd:COG2814   271 GRRRLLLIGLLLLALGLLLLALAGSLWLLLLALfLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
MFS_SV2A cd17439
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ...
 121-269 9.15e-06

Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340997 [Multi-domain]  Cd Length: 478  Bit Score: 46.95  E-value: 9.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387 121 LAFYSTNLAGNLYLNFVLMSLVEAPAYIFSPIFMNKYGRKVLISGTHIIAGLS--FLGIVLSSEAWHIHFWLLGKFAISc 198
Cdd:cd17439   327 LDFSDENNAYMIYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVScfFLSFGNSESAMIALLCLFGGVSIA- 405

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1831508387 199 SFMSIYMFASEIFPTDGRNKCIGFCETLSRFGGMLS-PYLSHLTAVHALAPAITLSLIAVSGGLLTLILPET 269
Cdd:cd17439   406 SWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGiSIFTSFVGITKAVPILLASAALAAGSSLALKLPET 477
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 2-237 1.09e-05

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 46.58  E-value: 1.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387   2 WVVGACFLGLLAYIL-PD--WRYLMFCISVPNIFVALLIYMTVPESLHFLVsSQQNEKIEAWLEKIRGPKGDISASDIVE 78
Cdd:TIGR00895 150 YPIGAAVGGFLAGWLiPVfgWRSLFYVGGIAPLLLLLLLMRFLPESIDFLV-SKRPETVRRIVNAIAPQMQAEAQSALPE 228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387  79 DRDENG---SSFKTLCREMWKHKMFIVYVLvmtyiWIVDTFIYFGLA----FYSTNLAGNLYLNFVLMSLVEAPAYIFSP 151
Cdd:TIGR00895 229 QKSTQGtkrSVFKALFQGKTARITVLLWLL-----YFMLLVGVYFLTnwlpKLMVELGFSLSLAATGGALFNFGGVIGSI 303

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387 152 IF---MNKYGRKVLISGTHIIAGLSFL-GIVLSSEAWHIHFWLLGKFAISCSFMSIYMFASEIFPTDGRNKCIGFCETLS 227
Cdd:TIGR00895 304 IFgwlADRLGPRVTALLLLLGAVFAVLvGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIG 383

                         250
                  ....*....|
gi 1831508387 228 RFGGMLSPYL 237
Cdd:TIGR00895 384 RLGAIIGPIL 393
Sugar_tr pfam00083
Sugar (and other) transporter;
3-223 1.27e-05

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 46.11  E-value: 1.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387   3 VVGACFLGLLAYILPD--WRYLMFCISVPNIFVALLIyMTVPESLHFLVSSQQNEKIEAWLEKIRGPKG-DISASDIVED 79
Cdd:pfam00083 152 LLAYIFGLGLNKTSNSdgWRIPLGLQLVPALLLIIGL-LFLPESPRWLVEKGRLEEAREVLAKLRGVPDvDRELDEIKDS 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387  80 RDENGSSFKTLCREMW--KHKMFIVYVLVMTYIWI----VDTFIYFGLAFYSTNLAGNLYLNFVLMSLVEAPAYIFSPIF 153
Cdd:pfam00083 231 LEAGQEAEKASWKELFstKTRRQRLLIGVMLQIFQqltgINAIFYYSTTIFENLGLSDSFLVTIIVGVVNFVFTFIAIFL 310

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387 154 MNKYGRK--VLISGTHIIAGLSFLGIV----LSSEAWH----IHFWLLGKFAISCSFMSI-YMFASEIFPTDGRNKCIGF 222
Cdd:pfam00083 311 VDRFGRRplLLLGAAGMAICFVILGIVallgVSKSDWAgivaIVFIALFIAFFAMGWGPVpWVIVSELFPLSVRSKAMAL 390


                  .
gi 1831508387 223 C 223
Cdd:pfam00083 391 A 391
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 11-214 1.58e-05

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 46.03  E-value: 1.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387  11 LLAYILP---DWRYL-MFCISVPNIFVALLIYMtvPESLHFLVSSQQNEKIEAWLEKIRGPKGDIS--ASDIVED----- 79
Cdd:cd17358   144 LLGYVLGsflPWRTLaLIGAIPPVVFLILLFFI--PESPRWLAKKGREEEAEKSLQFLRGKDADISkeAAEIQEElaele 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387  80 RDENGSSFKTLCREMWKHKMFIVYVLVMTYIWivdTFIyFGLAFYSTNL---AGNLY---LNFVLMSLVEAPAYIFSPIF 153
Cdd:cd17358   222 KEAKESSFSDLFQRKYLKPLVIGLGLMLFQQL---SGI-NAVIFYASSIfdeAGSGLdpnTATIIIGVVQVVGTLVATLL 297

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1831508387 154 MNKYGRKVL--ISGTHIIAGLSFLGIVLSSEAWHIHFWLLGKFAISCSFMSIYMFA-----------SEIFPTD 214
Cdd:cd17358   298 VDRLGRRPLllVSAIGMGIGLLALGLYFYLQEHGALLSSVSWLPLVGLVIYIISFSiglgplpwvimSEIFPAK 371
MFS_GLUT8_Class3 cd17433
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 1-236 5.73e-05

Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340991 [Multi-domain]  Cd Length: 416  Bit Score: 44.10  E-value: 5.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387   1 MWVVGaCFLGLLAYILPDWRYLMFCISVPNIFVaLLIYMTVPESLHFLVSSQQNEKIEAWLEKIRGPKGDIS--ASDIVE 78
Cdd:cd17433   138 MVVIG-IMGAYLAGLVLDWRWLAVLGSIPPTLM-LLLMCFMPETPRFLLTQHRRQEAMAALRFLRGPDQGWEweCIGIEQ 215

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387  79 DRDENGSSFK-TLCREMWKHKMFIVYVLVMTYIWI--VDTFIYFGLAFYSTNLAGNLYLNFVLMSLVEAPAYIFSPIFMN 155
Cdd:cd17433   216 SFHLEEQSFSlALLKQPGIYKPLIIGVSLMAFQQLtgINAVMFYAETIFEEAKFKDSSVASVIVAAIQVLFTAVAALIMD 295

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387 156 KYGRKVLISGTHIIAGLS---FLGIVLSSEAWHIHFWLLGKFAIScsfmsiYMFASEIFPTDGRNKCIGFC--------- 223
Cdd:cd17433   296 RAGRKVLLVLSGVVMVFStaaFGWLAVGSMGFFIAGFAVGWGPIP------WLVMSEIFPLHVRGVASGICvltnwlmaf 369

                         250
                  ....*....|....*.
gi 1831508387 224 ---ETLSRFGGMLSPY 236
Cdd:cd17433   370 lvtKEFSSLMEVLSSY 385
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 107-266 1.62e-04

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 42.80  E-value: 1.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387 107 MTYIWIVDTFIYFGLAFYSTNLAGNLYLNF----VLMSLVEAPAYIFSPI---FMNKYGRKVLISGTHIIAGLS-FLGIV 178
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQSFGLSAsqlgLLFALFSLGYALLQPLaglLADRFGRRPVLLLGLLLFALGaLLFAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387 179 LSSEAWHIHFWLLGKFAISCSFMSIYMFASEIFPTDGRNKCIGFCETLSRFGGMLSPYLSHLTAVHALAPAITLSLIAVS 258
Cdd:cd06174    81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAA 160


                  ....*...
gi 1831508387 259 GGLLTLIL 266
Cdd:cd06174   161 LALLAAIL 168
MFS_SVOP cd17441
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ...
 2-265 3.17e-04

Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340999 [Multi-domain]  Cd Length: 372  Bit Score: 41.72  E-value: 3.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387   2 WVVGACFLGLLAY-ILPD--WRYLMFCISVPNIFVALLIYMtVPESLHFLVSsqqnekieawlekirgpkgdisasdive 78
Cdd:cd17441   131 WALGTVFEVLLAVfVMPTlgWRWLLILSALPLLIFAVLCFW-LPESARYWTT---------------------------- 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387  79 drdengssfktlcremwkhkmfivyvLVMTYIWIVDTFIYFGLAFYSTNL--AGNL------------------------ 132
Cdd:cd17441   182 --------------------------ILLWFIWFSNAFSYYGLVLLTTELfqAGDVcsgssgkkvegkcsleceylttsd 235

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387 133 YLNFVLMSLVEAPAYIFSPIFMNKYGRKVLISGTHIIAGLSFLGIVLSSEAWHIH-FWLLGKFAISCSFMSIYMFASEIF 211
Cdd:cd17441   236 YMDLLWTTLSEFPGLLVTLWIIDRFGRKKTMALCFFVFSFCTLLLFSCVGRFSLTvLLFIARAFISGGFQAAYVYTPEVY 315

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1831508387 212 PTDGRNKCIGFCETLSRFGGMLSPYLSHLtavhALAPAITLSLIAVSG-GLLTLI 265
Cdd:cd17441   316 PTATRALGLGTCSGMARVGALITPFIAQV----MLESSVYLTLSVYSGcCLLAAI 366
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
95-288 1.15e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 39.96  E-value: 1.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387  95 WKHKMFIVYVLVMTYIWIVDTFIYFGLAFYSTNLAGNLYLNFVLMSLVEAPAYIFSPIF---MNKYGRKVLISGTHIIAG 171
Cdd:COG2814     7 RRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAgrlADRFGRRRVLLLGLLLFA 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387 172 LSFLGIVLSSEAWHIHFW-LLGKFAISCSFMSIYMFASEIFPTDGRNKCIGFCETLSRFGGMLSPYLSHLTAVHA---LA 247
Cdd:COG2814    87 LGSLLCALAPSLWLLLAArFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFgwrWV 166

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1831508387 248 PAITLSLIAVSGGLLTLILPETL---NTKLPSTIAETASRRQLI 288
Cdd:COG2814   167 FLVNAVLALLALLLLLRLLPESRpaaRARLRGSLRELLRRPRLL 210
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
77-262 4.01e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 38.30  E-value: 4.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387  77 VEDRDENGSSFKTLCREMWKHKMFIVYVL---------VMTYIWIVdtfIYFGLAF-YSTNLAGNLYLNFVLMSLVeapA 146
Cdd:COG0738   189 IEEEEEEAAGSAASLKSLLKNPRLLLGGLaiflyvgaeGAIGDWLP---LYLKDVLgLSEATAALGLSLFWGGMTI---G 262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387 147 YIFSPIFMNKYGRKVLISGTHIIAGLSFLGIVLSSEAWH--IHFWLLGkFAISCSFMSIYMFASEIFPTDGRNKcIGFCE 224
Cdd:COG0738   263 RFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLalIGLALVG-LGLSLMFPTIFSLALDGLGKRTAAA-VSAVL 340

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1831508387 225 TLSRFGGMLSP----YLSHLTAVHA--LAPAITLSLIAVSGGLL 262
Cdd:COG0738   341 IMGIVGGAIGPpligFLADAFGLRAafLVPLVCYLLILLLALAL 384
MFS_GLUT6_Class3 cd17434
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 1-227 4.37e-03

Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 6 (GLUT6) is also called Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6). It is classified as a Class 3 GLUT protein, and is a facilitative glucose transporter that binds cytochalasin B with low affinity. It is found in the brain, spleen, and leucocytes. GLUT6 may function in oxalate secretion. SLC2A6 has been identified as an oxalate nephrolithiasis gene in mice; its deletion causes spontaneous calcium oxalate nephrolithiasis in the setting of hyperoxalaemia, hyperoxaluria, and nephrocalcinosis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340992 [Multi-domain]  Cd Length: 417  Bit Score: 38.28  E-value: 4.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387   1 MWVVGACFLGLLAYILPdWRYLMFCISVPnIFVALLIYMTVPESLHFLVSSQQNEKIEAWLEKIRGPKGDISASDIVEDR 80
Cdd:cd17434   138 MAVFGSLALYALGLLLP-WRWLAVAGEVP-VVIMILLLCFMPNSPRFLISKGKDEKALKALAWLRGPNTDYMTEFEQIKD 215

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387  81 DENGSSFKTLCREMWKHKMF--IVYVLVMTYIW----IVDTFIYFGLAFYSTNLAGNLYLNFVLMSLVEAPAYIFSPIFM 154
Cdd:cd17434   216 NIRKQSSRLSWAELKTPSYYkpILIAVVMRFLQqltgITPILVYLEPIFHLTAVILEPKYDAALVGAVRLLSVAIAASLM 295

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1831508387 155 NKYGRKVLI---SGTHIIAGLSFLGIVLSSEAWHIHFWLLGKFAIScsfmsiYMFASEIFPTDGRNKCIGFCETLS 227
Cdd:cd17434   296 DKAGRKILLftsAFLMFAANLSMGLIPLIAAMLFIMGYAMGWGPIT------WLLMSEILPLKARGVASGLCVVVS 365
MFS_1 pfam07690
Major Facilitator Superfamily;
101-235 8.68e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 37.40  E-value: 8.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387 101 IVYVLVMTYIWIVDTFIYFGLAFYSTNLAGNLYLN------------FVLMSLVEAPAYIFSPIFMNKYGRKVLISGTHI 168
Cdd:pfam07690 194 WKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEvlglsallagllLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALL 273

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1831508387 169 IAGLSFLGIVLSSEAWHIHFWLLG----KFAISCSFMSIYMFASEIFPTDGRNKCIGFCETLSRFGGMLSP 235
Cdd:pfam07690 274 LLILAALGLLLLSLTLSSLWLLLAllllGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 2-269 9.39e-03

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 37.28  E-value: 9.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387   2 WVVGACFLGLLAYIL-PD------WRYLMFCISVPnIFVALLIYMTVPESlhflvssqqnekiEAWLEKIRGPKGDISAS 74
Cdd:cd17371   132 WAVGWLLATLLAALLfPLlppeiaWRVLFLLGALP-ALLVLFIRRFVKEP-------------PQWQAARAARRHFADRP 197

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387  75 DIVEdrdenGSSFKTLcremwkhKMFIVYVLVMTyiwiVDTFIYFG-LAFYSTNLAGNLYLNFVLMSLVEAP-------A 146
Cdd:cd17371   198 SLRE-----LFSPPLL-------RTTLLASLLAT----GALGGYYGiTTWLPSYLTGERGLSFEGSAGYLVVtilggflG 261

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508387 147 YIFSPIFMNKYGRKVLISGTHIIAGLSFLGIVLSSEAWHIHFWL---LGKFAISC-SFMSIYMfaSEIFPTDGRNKCIGF 222
Cdd:cd17371   262 YLAGGFLADRIGRRNNFALFALGSAISILLYFFLPLSPTLILILgfpLGFFASGPfSGMGAYL--TELFPTAVRATAQGF 339

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1831508387 223 CETLSRFGGMLSPYLSHLTAVH-ALAPAI-TLSLIAVS-GGLLTLILPET 269
Cdd:cd17371   340 CYNVGRIIGALFPFLVGFLATSgSLGTAIaVFAAVYYIaGLVLALLLPET 389
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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