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Conserved domains on  [gi|1831507189|ref|NP_001366886|]
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Acidic leucine-rich nuclear phosphoprotein 32-related protein 1 [Caenorhabditis elegans]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 43-151 1.39e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 50.17  E-value: 1.39e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831507189  43 LEMLSMVKCGLTTLAGFPTLPALTYLDISDNQLGDnasFDVLvknapdlkkitlasnklsldnLRCLKVLPNLFELDLSN 122
Cdd:cd21340   122 LRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISD---LEEL---------------------LDLLSSWPSLRELDLTG 177

                          90       100
                  ....*....|....*....|....*....
gi 1831507189 123 NPsLGLLEDYREKMFEMIPSLKILDGCDV 151
Cdd:cd21340   178 NP-VCKKPKYRDKIILASKSLEVLDGKEI 205
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 43-151 1.39e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.17  E-value: 1.39e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831507189  43 LEMLSMVKCGLTTLAGFPTLPALTYLDISDNQLGDnasFDVLvknapdlkkitlasnklsldnLRCLKVLPNLFELDLSN 122
Cdd:cd21340   122 LRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISD---LEEL---------------------LDLLSSWPSLRELDLTG 177

                          90       100
                  ....*....|....*....|....*....
gi 1831507189 123 NPsLGLLEDYREKMFEMIPSLKILDGCDV 151
Cdd:cd21340   178 NP-VCKKPKYRDKIILASKSLEVLDGKEI 205
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
39-124 4.19e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.93  E-value: 4.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831507189  39 QLINLEMLSMVKCGLTTL-AGFPTLPALTYLDISDNQLGDNASFdvlvKNAPDLKKITLASNKLSldNLRCLKVLPNLFE 117
Cdd:COG4886   203 NLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPEL----GNLTNLEELDLSNNQLT--DLPPLANLTNLKT 276


                  ....*..
gi 1831507189 118 LDLSNNP 124
Cdd:COG4886   277 LDLSNNQ 283
LRR_8 pfam13855
Leucine rich repeat;
63-124 9.00e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 9.00e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1831507189  63 PALTYLDISDNQLG--DNASFdvlvKNAPDLKKITLASNKLSLDNLRCLKVLPNLFELDLSNNP 124
Cdd:pfam13855   1 PNLRSLDLSNNRLTslDDGAF----KGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
LRRcap smart00446
occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich ...
 129-147 3.00e-04

occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich repeats in "sds22-like" and "typical" LRR-containing proteins.


Pssm-ID: 197729  Cd Length: 19  Bit Score: 36.90  E-value: 3.00e-04
                           10
                   ....*....|....*....
gi 1831507189  129 LEDYREKMFEMIPSLKILD 147
Cdd:smart00446   1 LAHYREKVIELLPQLRKLD 19
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 43-151 1.39e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.17  E-value: 1.39e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831507189  43 LEMLSMVKCGLTTLAGFPTLPALTYLDISDNQLGDnasFDVLvknapdlkkitlasnklsldnLRCLKVLPNLFELDLSN 122
Cdd:cd21340   122 LRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISD---LEEL---------------------LDLLSSWPSLRELDLTG 177

                          90       100
                  ....*....|....*....|....*....
gi 1831507189 123 NPsLGLLEDYREKMFEMIPSLKILDGCDV 151
Cdd:cd21340   178 NP-VCKKPKYRDKIILASKSLEVLDGKEI 205
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
39-124 4.19e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.93  E-value: 4.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831507189  39 QLINLEMLSMVKCGLTTL-AGFPTLPALTYLDISDNQLGDNASFdvlvKNAPDLKKITLASNKLSldNLRCLKVLPNLFE 117
Cdd:COG4886   203 NLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPEL----GNLTNLEELDLSNNQLT--DLPPLANLTNLKT 276


                  ....*..
gi 1831507189 118 LDLSNNP 124
Cdd:COG4886   277 LDLSNNQ 283
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
22-123 3.37e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 47.24  E-value: 3.37e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831507189  22 TLFLDNAEDGQIGGLTDQLINLEMLSMVKCGLTTL-AGFPTLPALTYLDISDNQLGDnasFDVLVKNAPDLKKITLASNK 100
Cdd:COG4886   117 SLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTD---LPEELGNLTNLKELDLSNNQ 193

                          90       100
                  ....*....|....*....|....
gi 1831507189 101 LSldNLRC-LKVLPNLFELDLSNN 123
Cdd:COG4886   194 IT--DLPEpLGNLTNLEELDLSGN 215
LRR_8 pfam13855
Leucine rich repeat;
63-124 9.00e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 9.00e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1831507189  63 PALTYLDISDNQLG--DNASFdvlvKNAPDLKKITLASNKLSLDNLRCLKVLPNLFELDLSNNP 124
Cdd:pfam13855   1 PNLRSLDLSNNRLTslDDGAF----KGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
39-130 2.15e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 44.54  E-value: 2.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831507189  39 QLINLEMLSMVKCGLTTLAGFPTLPALTYLDISDNQLGDNASFdvlvKNAPDLKKITLASNKLSLDNLRCLKVLPNLFEL 118
Cdd:COG4886   226 NLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPL----ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSL 301

                          90
                  ....*....|..
gi 1831507189 119 DLSNNPSLGLLE 130
Cdd:COG4886   302 LLLLLLLNLLEL 313
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
39-124 3.31e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 44.15  E-value: 3.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831507189  39 QLINLEMLSMVKCGLTTL-AGFPTLPALTYLDISDNQLGDnasFDVLVKNAPDLKKITLASNKLS-LDNLrcLKVLPNLF 116
Cdd:COG4886   111 NLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTD---LPEPLGNLTNLKSLDLSNNQLTdLPEE--LGNLTNLK 185


                  ....*...
gi 1831507189 117 ELDLSNNP 124
Cdd:COG4886   186 ELDLSNNQ 193
LRRcap smart00446
occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich ...
 129-147 3.00e-04

occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich repeats in "sds22-like" and "typical" LRR-containing proteins.


Pssm-ID: 197729  Cd Length: 19  Bit Score: 36.90  E-value: 3.00e-04
                           10
                   ....*....|....*....
gi 1831507189  129 LEDYREKMFEMIPSLKILD 147
Cdd:smart00446   1 LAHYREKVIELLPQLRKLD 19
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 53-147 1.60e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.23  E-value: 1.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831507189  53 LTTLAGFPTLPALTYLDISDNQLGDNASFDVLVKnapdLKKITLASNKLS-LDNLRClkvLPNLFELDLSNN---PSLGL 128
Cdd:cd21340    36 ITKIENLEFLTNLTHLYLQNNQIEKIENLENLVN----LKKLYLGGNRISvVEGLEN---LTNLEELHIENQrlpPGEKL 108

                          90
                  ....*....|....*....
gi 1831507189 129 LEDYReKMFEMIPSLKILD 147
Cdd:cd21340   109 TFDPR-SLAALSNSLRVLN 126
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
6-123 2.19e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 38.76  E-value: 2.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831507189   6 EIYVKELRERDPATVDTLFLDNAEDGQIGGLTD--QLINLEMLSmvkcgLTTLAGFPTLPALTYLDISDNQLGDnasFDV 83
Cdd:COG4886    59 DLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDlgDLTNLTELD-----LSGNEELSNLTNLESLDLSGNQLTD---LPE 130

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1831507189  84 LVKNAPDLKKITLASNKLSlDNLRCLKVLPNLFELDLSNN 123
Cdd:COG4886   131 ELANLTNLKELDLSNNQLT-DLPEPLGNLTNLKSLDLSNN 169
LRR_9 pfam14580
Leucine-rich repeat;
56-147 4.11e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 37.05  E-value: 4.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831507189  56 LAGFPTLPALTYLDISDNQL---GDNasfdvLVKNAPDLKKITLASNKL-SLDNLRCLKVLPNLFELDLSNNPsLGLLED 131
Cdd:pfam14580  57 LDGFPLLRRLKTLLLNNNRIcriGEG-----LGEALPNLTELILTNNNLqELGDLDPLASLKKLTFLSLLRNP-VTNKPH 130

                          90
                  ....*....|....*.
gi 1831507189 132 YREKMFEMIPSLKILD 147
Cdd:pfam14580 131 YRLYVIYKVPQLRLLD 146
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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