|
Name |
Accession |
Description |
Interval |
E-value |
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
13-370 |
5.06e-138 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 401.37 E-value: 5.06e-138
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 13 TIIYFAHIYFRRLPITLLPLIREEIVLTSDDIGILVSSHALLYTIGRLLFGMASDRYSKVALLLLGLVTCAACSVGLAFS 92
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 93 NHLWQMLIAMMLLGIVQGAGWVPATLLVQSWYSKSTYGTMFSILACGSTFAGILQP----FSKKFYWRNVELYTGAG--M 166
Cdd:TIGR00881 81 TSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPplvlFGIAELYSWHWVFIVPGiiA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 167 LVFSIVCFIVLREDNVSPKQTEDDEEPNPE------------KKKKGGLRTIVGSIVIWHISFVYLFTMEMRTICETWVQ 234
Cdd:TIGR00881 161 IIVSLICFLLLRDSPQSCGLPPAEEMPNEEpdgdaekkeeelTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGILDWSP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 235 LFLTD----SKISPDAFQITYEIGGLVGTMASGIVIDLatrkfDVDATRRVIAVSYTCLMMFSAAGIFEFAELS----SI 306
Cdd:TIGR00881 241 LYLTQekgfSKEKASWAFTLYELGGLVGTLLAGWLSDK-----LFNGRRGPLAVFFMALIIVSLLVYWLNPAANplmdLI 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1831518188 307 FGFLAGMFVNGSINVWCMIASQAGFSKIQGTVSAFISFIASSGSMLAGTPLAYLISVFGWKVFL 370
Cdd:TIGR00881 316 CLFALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFGWAGAF 379
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
5-387 |
8.34e-112 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 333.86 E-value: 8.34e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 5 THIKFVVVTIIYFAHIYFRRLPITLLPLIREEIVLTSDDIGILVSSHALLYTIGRLLFGMASDRYSKVALLLLGLVTCAA 84
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 85 CSVGLAFSNHLWQMLIAMMLLGIVQGAGWVPATLLVQSWYSKSTYGTMFSILACGSTFAGILQPFSKKFY-----WRNVE 159
Cdd:cd17312 81 ANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLasyygWRAAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 160 LYTGAGMLVFSIVCFIVLREDNvspkqteddeepnpekkkkgglrtivgsIVIWHISFVYLFTMEMRTICETWVQLFLTD 239
Cdd:cd17312 161 LVPGIVGLVVAIILFFFLRDSP----------------------------PYVWVLSLAYAFVYIVRYACLDWGPLYLYE 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 240 ----SKISPDAFQITYEIGGLVGTMASGIVIDLAtrkfdVDATRRVIAVSYTCLMMFSAAGIFEF---AELSSIFGFLAG 312
Cdd:cd17312 213 vkgySLIDAGWFSSLYEVGGIAGTILAGLLSDKL-----FGGRRAPIAVIYMLLMTLSLALFWFFphnKLLSIVLLFLIG 287
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1831518188 313 MFVNGSINVWCMIASQAGFSK-IQGTVSAFISFIASSGSMLAGTPLAYLISVFGW-KVFLYIFSVQLVIVLFVSSFR 387
Cdd:cd17312 288 FFVGGPINLIGGAAAQDIGRKeAAGTATGFVGLFGYLGASLAGLPLGYIIDHYGWsTVFYFLISAALLSVLLLLSLW 364
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
9-387 |
6.62e-45 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 161.35 E-value: 6.62e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 9 FVVVTIIYFAHIYFRRLPITLLPLIREEIVLTSDDIGILVSSHALLYTIGRLLFGMASDRYSKVALLLLGLVTCAACSVG 88
Cdd:cd17343 5 FASMFVGYTLYYFNRKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGLTTVA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 89 LAFSNHLWQMLIAMMLLGIVQGAGWVPATLLVQSWYSKSTYGTMFSILACGSTFAGILQPF-----SKKFYWRNVELYTG 163
Cdd:cd17343 85 FSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPIlatllALSYGWRSTLSISG 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 164 AGMLVFSIVCFIVLREDNVSPKQTEDDEEPNPEKKKK-----GGLRTIVGSIVIWHISFVYLFTMEMRTICETWVQLFLT 238
Cdd:cd17343 165 TVAVVMSVVCLLFIKNEPSDVGLNNIEEEESKGKKKKsprgeSTLKELLLSPFLWLLSLGYLVVFGVKTAVTDWGQLFLI 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 239 DSK----ISPDAFQITYEIGGLVGTMASGIVIDLATRKFDVDAT---RRVIAVSYtclMMFSAAGIFEF-----AELSSI 306
Cdd:cd17343 245 QDKgqsaLTGSSFMSSLEVGGFVGSIAAGYLSDWAVAKHGSSSRgnpRMPLALVF---MAGLTVSLHLFrvhitSDSSEL 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 307 F----GFLAGMFVNGSINVWCMIASQAGFSKIQGTVSAFISFIASSGSMLAGTPLAYLISVFGWK-VFLYIFSVQLVIVL 381
Cdd:cd17343 322 FilllGFLIGFSLYGPIAIFGVIANESAPSHLCGTSHAIVALAANVGGVLAGLPFSYIAKHYDWRtAFLLLEILCAITVV 401
|
....*.
gi 1831518188 382 FVSSFR 387
Cdd:cd17343 402 ILFLLR 407
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
9-389 |
3.08e-29 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 117.66 E-value: 3.08e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 9 FVVVTIIYFAHIYFRRLPITLLPLIREEIVLTSDDIGILVSSHALLYTIGRLLFGMASDRYSKVALLLLGLVTCAACSVG 88
Cdd:COG2271 12 LALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 89 LAFSNHLWQMLIAMMLLGIVQGAGWVPATLLVQSWYSKSTYGTMFSILACGSTFAGILQPF-----SKKFYWRNVelytg 163
Cdd:COG2271 92 FGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPllgwlLAAFGWRAA----- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 164 agMLVFSIVCFivlrednvspkqteddeepnpekkkkgglrtIVGSIVIWHISFVYLFTMEMRTICETWVQLFLTDSK-I 242
Cdd:COG2271 167 --FLILGLPGL-------------------------------LLALLRFWLLALAYFLVYFALYGFLTWLPTYLVEVRgL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 243 SPDA---FQITYEIGGLVGTMASGIVIDLATRKfdvdaTRRVIAVSYTCLM-MFSAAGIFEFAELSSIFGFLAGMFVNG- 317
Cdd:COG2271 214 SLAQaglLLSLPFLAGIVGSLLGGWLSDRLGRR-----RKLVLAIGLLLAAlALLLLALLPSPALAIALLFLAGFGLGGa 288
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1831518188 318 SINVWCMIASQAGfSKIQGTVSAFISFIASSGSMLAGTPLAYLISVFGWKVFLYIFSVQLVIVLFVSSFRVR 389
Cdd:COG2271 289 FGLLWALAAELFP-KKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLR 359
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
9-398 |
1.31e-23 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 101.88 E-value: 1.31e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 9 FVVVTIIYFAHIYFRRLPITLLPLIREEIVLTSDDIGILVSSHALLYTIGRLLFGMASDRYSKVALLLLGLVTCAACSVG 88
Cdd:COG2223 7 LLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 89 LAFSNHLWQMLIAMMLLGIVQGAGWVPATLLVQSWYSKSTYGTMFSILACGSTF-AGILQPFS----KKFYWRNVELYTG 163
Cdd:COG2223 87 LALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLgAAVAAFLAplliAAFGWRNAFLILG 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 164 AGMLVFSIVCFIVLREDnvspkqteDDEEPNPEKKKKGGLRTIVGSIVIWHISFVYLFTMEMRTICETWVQLFLTDS-KI 242
Cdd:COG2223 167 ILLLVVAVLAWLFLRDP--------PAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQfGL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 243 SP-DAFQIT--YEIGGLVGTMASGIVIDLATRkfdvdatRRVIAVSYT-----CLMMFSAAGIFEFAELSSIFGFLAGMF 314
Cdd:COG2223 239 SAaTAGLLAalFALLGALGRPLGGWLSDRIGG-------RRVLLIVFAlmalgLLLLALALGSLWLFLVLFLLLGLALGG 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 315 VNGSinVWCMIASQAGfSKIQGTVSAFISFIASSGSMLAGTPLAYLISVFG-WKVFLYIFSVqLVIVLFVSSFRVRLRMD 393
Cdd:COG2223 312 GNGA--VFALVPDIFP-TKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAV-LALVALVLTLLLYRRPR 387
|
....*
gi 1831518188 394 TTENE 398
Cdd:COG2223 388 RAAAA 392
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
7-381 |
5.14e-23 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 99.79 E-value: 5.14e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 7 IKFVVVTIIYFAHIYFRRLPITL-LPLIREEIVLTSDDIGILVSSHALLYTIGRLLFGMASDRYSKVALLLLGLVTCAAC 85
Cdd:cd17488 2 IHILASMFIGYAVFYLTRKSFNAaMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGII 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 86 SVGLAFSNHLWQMLIAMMLLGIVQGAGWVPATLLVQSWYSKSTYGTMFSILACGSTFAGILQP----FSKKFY-WRNVEL 160
Cdd:cd17488 82 NILFGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPiltgFAALTYgWRAGMY 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 161 YTGAGMLVFSIVCFIVLREdnvSPKqteddeepnpekkkkgglrtivgsiVIWHISFVYLFTMEMRTICETWVQLFLTDS 240
Cdd:cd17488 162 VPGIIAILMGIVLCWRLRD---RPP-------------------------YIWLLAFCYVLVYVVRTAINDWGNLYLSET 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 241 K----ISPDAFQITYEIGGLVGTMASGIVIDLATRkfdvdATRRVIAVSYTCLMMFSAAGIF-----EFAELSSIFgFLA 311
Cdd:cd17488 214 HgyslVKANSAVSLFEVGGLIGALVAGWGSDKLFK-----GNRGPMNLIFALGLLVSVGALWlvpvhSYWLLATCF-FTI 287
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 312 GMFVNGSINVWCMIASQAGFSKIQGTVSAFISFIASSGSMLAGTPLAYLISVFGWKVFLYIFSVQLVIVL 381
Cdd:cd17488 288 GFFVFGPQMLIGMAAAECSHKDAAGSATGFVGLFAYLGAALAGYPLAKVIESWGWSGFFIVISIAAAISG 357
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
9-384 |
8.06e-23 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 100.01 E-value: 8.06e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 9 FVVVTIIYFAHiYFRRLPITLL-PLIREEIVLTSDDIGILVSSHALLYTIGRLLFGMASDRYSKVALLLLGLVTCAACSV 87
Cdd:cd17345 5 FLGIFIGYAGY-YLVRNNFSLAqPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 88 GLAFSNH----LWQMLIAMMLLGIVQGAGWVPATLLVQSWYSKSTYGTMFSILAC----GSTFAGILQPFSKKFY----W 155
Cdd:cd17345 84 LIGFVPSatssVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNIshnvGGGLVGPLAGLGLAIFgdgwW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 156 RNVELYTGAGMLVFSIVCFIVLREDNVS-------------PKQTEDDEEPNPEKKKKGGLRTIVGSIVIWHISFVYLFT 222
Cdd:cd17345 164 RGAFIFPAIIAIIVAVIVLFLGKDTPESeglppieeykgdyPEEADGEEEEQELSAWEIFVKYVLKNKLLWYIAIANVFV 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 223 MEMRTICETWVQLFLTDSK-ISPDAFQIT---YEIGGLVGTMASGIVIDLATRkfdvdaTRRVIAVSYTCLMMFSAAGIF 298
Cdd:cd17345 244 YLVRYGILDWAPTYLSEVKgFSKAQAMWAfslFEWAAIPGTLLAGWLSDKLFK------GRRAPTGIIFMILVIVALIVY 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 299 EFAE---LSSIFGFLAGMFVNGS---INVWCM-------IASQAGFSkiqGTVSAFIsfiassGSMLAGTPLAYLISVFG 365
Cdd:cd17345 318 WLAPnvlVDLIALIALGFLIYGPvmlIGLQALelvpkkaAGTAAGLT---GLFGYLG------GSVLATALIGIIVDHFG 388
|
410 420
....*....|....*....|..
gi 1831518188 366 WK---VFLYIFSVQLVIVLFVS 384
Cdd:cd17345 389 WNggfIVLLASCILAIIFLALV 410
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
9-353 |
1.31e-21 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 95.43 E-value: 1.31e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 9 FVVVTIIYFAHIYFRRLPITLLPLIREEIVLTSDDIGILVSSHALLYTIGRLLFGMASDRYSKVALLLLGLVTCAACSVG 88
Cdd:COG2814 12 LLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 89 LAFSNHLWQMLIAMMLLGIVQGAGWVPATLLVQSWYSKSTYGTMFSILACGSTFAGILQPF-----SKKFYWRNVELYTG 163
Cdd:COG2814 92 CALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLlggllADLFGWRWVFLVNA 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 164 AGMLVFSIVCFIVLREDnvspkqteddeEPNPEKKKKGGLRTIVGSIVIWHISFVYLFTMEMRTICETWVQLFLTD-SKI 242
Cdd:COG2814 172 VLALLALLLLLRLLPES-----------RPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEvLGL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 243 SPDAFQITYEIGGLVGTMASGIVIDLATRKfdvdATRRVIAVSytclMMFSAAGIFEFAELSSIFGFLAGMFVNGSINVW 322
Cdd:COG2814 241 SASAAGLLLALFGLGGVLGALLAGRLADRF----GRRRLLLIG----LLLLALGLLLLALAGSLWLLLLALFLLGFGFGL 312
|
330 340 350
....*....|....*....|....*....|....*.
gi 1831518188 323 CMIASQAGFSKI-----QGTVSAFISFIASSGSMLA 353
Cdd:COG2814 313 LFPLLQALVAELappeaRGRASGLYNSAFFLGGPLA 348
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
12-353 |
1.87e-21 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 95.18 E-value: 1.87e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 12 VTIIYFAHIYFRRLPITLLPL-IREEIVLTSDDIGILVSSHALLYTIGRLLFGMASDRYSKVALLLLGLVTCAACSVGLA 90
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 91 FSNHLWQMLIAMMLLGIVQGAGWVPATLLVQSWYSKSTYGTMFSILACGSTFAGILQP-----FSKKFYWRNVELYTGAG 165
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPllgglLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 166 MLVFSIVCFIVLREdnvsPKQTEDDEEPNPEKKKKGGLRTIVGSIVIWhISFVYLFTMEMRTICETWVQLFLTDSKISPD 245
Cdd:pfam07690 161 SLLAAVLLLLPRPP----PESKRPKPAEEARLSLIVAWKALLRDPVLW-LLLALLLFGFAFFGLLTYLPLYQEVLGLSAL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 246 AFQITYEIGGLVGTMASGIVIDLATRKFDVDATRRVIAVSYTCLMMFSAAGIFEFAELSSIFGFLAGMFVNGSINVWCMI 325
Cdd:pfam07690 236 LAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNAL 315
|
330 340
....*....|....*....|....*...
gi 1831518188 326 ASQAGFSKIQGTVSAFISFIASSGSMLA 353
Cdd:pfam07690 316 VSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
12-384 |
4.25e-20 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 91.72 E-value: 4.25e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 12 VTIIYFAHIYFRRLPITLLPLIREEIVLTSDDIGILVSSHALLYTIGRLLFGMASDRYSKVALLLLGLVTCAACSVGLAF 91
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 92 SNHLWQMLIAMMLLGIVQGAGWVPATLLVQSWYSKSTYGTMFSILACGSTFAGILQPF-------SKKFYWRNVELYTGA 164
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLlggilasSLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 165 GMLVFSIVCFIVLREDnvsPKQTEDDEEPNPEKKKKGGLRTIVGSIVIWHISFVYLFTMEMRTICETWVQLFLTDSKISP 244
Cdd:cd06174 161 LALLAAILLLLVVPDP---PESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLS 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 245 DAF----QITYEIGGLVGTMASGIVIDLATRkfdvdaTRRVIAVSYTCLMMFSAAGIFEFAELSSIFGFLAGMFVNGSIN 320
Cdd:cd06174 238 VAVagllLSLFGLAGALGSLLLGLLSDRLIG------RKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLL 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1831518188 321 VWCM-IASQAGFSKIQGTVSAFISFIASSGSMLAGTPLAYLIS-VFGWKVFLYIFSVQLVIVLFVS 384
Cdd:cd06174 312 PLSFaLIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAaTFGLTGAFLVLAVLLLLAAILL 377
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
15-375 |
9.79e-19 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 88.23 E-value: 9.79e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 15 IYFAHIYFRRLPITL-LPLIREEIVLTSDDIGILVSSHALLYTIGRLLFGMASDRYSKVALLLLGLVTCAACSVGLAFSN 93
Cdd:PRK11663 30 LGYALFYFTRKSFNAaMPEMLADLGLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFSS 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 94 HLWQMLIAMMLLGIVQGAGWVPATLLVQSWYSKSTYGTMFSILACGSTFAGILQPF-----SKKFYWRnvelytgAGMLV 168
Cdd:PRK11663 110 SLWAFALLWVLNAFFQGWGWPVCAKLLTAWYSRTERGGWWAIWNTAHNVGGALIPLvvgaiALHYGWR-------YGMMI 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 169 FSIVCFIV-------LREDNV-----SPKQTEDDEEPNPEKKKKGGL--RTIVGSIV-----IWHISFVYLFTMEMRTIC 229
Cdd:PRK11663 183 AGIIAIVVglflcwrLRDKPQamglpSVGEWRHDALELAQQQEGAGLsrKEILTKYVllnpyIWLLSFSYVLVYVVRAAI 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 230 ETWVQLFLTDSK----ISPDAFQITYEIGGLVGTMASGIVIDlatRKFdvDATRRVIAVSYTCLMMFSAAG-----IFEF 300
Cdd:PRK11663 263 NDWGNLYMSETLgvdlVTANSAVSMFELGGFIGALVAGWGSD---KLF--NGNRGPMNLIFAAGILLSVGSlwlmpFASY 337
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1831518188 301 AELSSIFgFLAGMFVNGSINVWCMIASQAGFSKIQGTVSAFISFIASSGSMLAGTPLAYLISVFGWKVFLYIFSV 375
Cdd:PRK11663 338 VMQAACF-FTIGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYLGAALSGYPLAKVLEIWHWTGFFVVISI 411
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
25-388 |
2.32e-18 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 86.48 E-value: 2.32e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 25 LPITLLPLIREEIVLTSDDIGILVSSHALLYTIGRLLFGMASDRYSKVALLLLGLVTCAACSVGLAFSNHLWQMLIAMML 104
Cdd:cd17325 14 IIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 105 LGIVQGAGWVPATLLVQSWYSKSTYGTMFSILACGSTFAGILQP-----FSKKFYWRNVELYTGAGMLVFSIVCFIVLRE 179
Cdd:cd17325 94 QGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPllgglLADALGYRAPFLVCAALALLALVLALLLLPE 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 180 DNVSPKQTEDDEEPNPEKK----KKGGLRTIVGSIVIWHISFVYLFTMemrticetwVQLFLTDS-KISPDAFQITYEIG 254
Cdd:cd17325 174 PRPPPNKRAVSAARLRSGLrlllRDRRLLALFLAIFVLAFAFGALEPF---------LPLYAAELgGLSPAQIGLLFGAQ 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 255 GLVGTMASGIVIDLATRKfdvdATRRVIAVSYTclmmFSAAGIFEFAELSSIFGFLAGMFVNGSINVWCMIASQAGFSKI 334
Cdd:cd17325 245 GLASALSQPPAGKLSDRI----GRKPLILIGLL----LSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADI 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1831518188 335 -----QGTVSAFISFIASSGSMLAGTPLAYLISVFGWKVFLYIFSVQLVIVLFVSSFRV 388
Cdd:cd17325 317 vppegRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
29-379 |
1.28e-14 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 74.91 E-value: 1.28e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 29 LLPLIREEIVLTSDDIGILVSSHALLYTIGRLLFGMASDRYSKVALLLLGLVTCAACSVGLAFSNHLWQMLIAMMLLGIV 108
Cdd:cd17319 25 AAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 109 QGAGWVPATLLVQSWYSKSTYGTMFSILACGSTFAGILQP-----FSKKFYWRNVELYTGAGMLVFSIVCFIVLRednvs 183
Cdd:cd17319 105 EAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPplsgwLLLLFGWRWAFIIEGLLGLLLAVLWWFYLR----- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 184 pkqteddeepnpekkkkgglrtivgsiVIWHISFVYLFTMEMRTICETWVQLFLTDSKISPDA----FQITYEIGGLVGT 259
Cdd:cd17319 180 ---------------------------QVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKqvglLAAIPFLAGAIGM 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 260 MASGIVIDlatrKFDVDATRRVIAVSYTCLM-MFSAAGIFEFAELSSIFGFLAGMFVNGSINVWCMIASQAGFSKIQGTV 338
Cdd:cd17319 233 ILGGRLSD----RLLRGARRLVIIIGLLLAAvGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATA 308
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1831518188 339 SAFISFIASSGSMLAGTPLAYLISVFG-WKVFLYIFSVQLVI 379
Cdd:cd17319 309 GGLINSGGNLGGFVAPLLIGYLVDATGsYTAAFLFLAAVALL 350
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
9-384 |
1.20e-13 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 72.20 E-value: 1.20e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 9 FVVVTIIYfahiyfrrLPITLLPLIREEIVLTSDDIGILVSSHALLYTIGRLLFGMASDRYSKVALLLLGLVTCAACSVG 88
Cdd:cd17324 9 FAIGTTEY--------VIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 89 LAFSNHLWQMLIAMMLLGIVQGAGWVPATLLVQSWYSKSTYGTMFSILACGSTFAGIL-QPFS----KKFYWRNVELYTG 163
Cdd:cd17324 81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLgRPLGgllgQLLGWRAAFLAIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 164 AGMLVFSIVCFIVLREDNVSPKQTEDDEEPNPEKKKKGGLRTIVGSIVIWHISFVYLFtmemrticeTWVQLFLTDSKIS 243
Cdd:cd17324 161 VLALLAALLLWRLLPSLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALY---------TYLAPFLTDVPGF 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 244 PDAFQI----TYEIGGLVGTMASGIVIDlatrkfdvdatRRVIAVSYTCLMMFSAAGIFEFAELSSIFGFLAGMFVNGSI 319
Cdd:cd17324 232 SSSAIIglllLFGVAGVVGSPLAGRLAD-----------RGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLG 300
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1831518188 320 NVWCMIASQAGFSKI----QGTVSAFISFIASSGSMLAGTPLAYLISVFGWKVFLYIFSVQLVIVLFVS 384
Cdd:cd17324 301 FFAAHSALQTRVLRLapeaRGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLA 369
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
28-391 |
4.55e-12 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 67.19 E-value: 4.55e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 28 TLLPLIREEIVLTSDDIGILVSSHALLYTIGRLLFGMASDRYSKVALLLLGLVTCAACSVGLAFSNHLWQMLIAMMLLGI 107
Cdd:COG0738 29 PLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 108 VQGAGWVPATLLVQSWYSK------STYGTMFSI-LACGSTFAGILQPFSKKFYWRNVELYTGAGMLVFSIVCFIVLRed 180
Cdd:COG0738 109 GLGLLDVAANPYVAALGPEtaasrlNLLHAFFSLgALLGPLLGGLLILLGLSLSWHLPYLILAVLLLLLALLFLRSKL-- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 181 nvsPKQTEDDEEPNPEKKKKGGLRTIVGSIVIWHISFVYLFTMemrTICETWVQLFLTDSKISPDAFQITYEIGGLVGTM 260
Cdd:COG0738 187 ---PEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAE---GAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMT 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 261 ASGIVIDLATRKFDVdatRRVIAVSYTCLMMFSAAGIFEFAELSSIFGF-LAGMFVNgsiNVWCMIASQA--GFSKIQGT 337
Cdd:COG0738 261 IGRFLGGFLLKRFGP---VRLLRLSALLAAVGLLLALLAPGPWLALIGLaLVGLGLS---LMFPTIFSLAldGLGKRTAA 334
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1831518188 338 VSAFISFIASSGSMLAGTPLAYLISVFGWKVFLYIFSVQLVIVLFVSSFRVRLR 391
Cdd:COG0738 335 AVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKR 388
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
24-388 |
2.15e-11 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 65.28 E-value: 2.15e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 24 RLPIT----LLPLIREEIVLTSDDIGILVSSHALLYTIGRLLFGMASDRYSKVALLLLGLVTCAACSVGLAFSNHLWQML 99
Cdd:COG2807 31 RPAITsvgpLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLL 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 100 IAMMLLGIVQGAGWVPATLLVQSWYSKSTyGTMFSI----LACGSTF-AGILQPFSKKFYWRNVELYTGAGMLVFSIVCF 174
Cdd:COG2807 111 AGTALIGAGIAVGNVLLPGLIKRWFPDRV-GLMTGLytaaMGLGAALaAGLTVPLAAALGWRGALAVWALLALLALLLWL 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 175 IVLREDNVSPkqteddeepnPEKKKKGGLRTIVGSIVIWHISFVYLFTMEMRTICETWVQLFLTDSKISPDAfqityeIG 254
Cdd:COG2807 190 PLLRRRPAAA----------AAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAAT------AG 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 255 GLVGTMA-----SGIVIDLATRKFdvdATRRVIAVSYTCLMMFSAAG-IFEFAELSSIFGFLAGmFVNGSINVWCMI--- 325
Cdd:COG2807 254 LLLSLFQlagipGSLLVPLLADRL---GDRRPLLLLLGLLGLAGLLGlLLAPGSLPWLWAVLLG-LGQGGLFPLALTlig 329
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1831518188 326 ---ASQAGFSKIQGTVSAFISFIASSGSMLAGtplaYLISVFG-WKVFLYIFSVqLVIVLFVSSFRV 388
Cdd:COG2807 330 lraRTPAEAAALSGMAQSVGYLLAALGPLLVG----ALHDATGsWTAALLLLAA-LAVLMLVAGLLA 391
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
30-361 |
3.36e-11 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 64.69 E-value: 3.36e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 30 LPLIREEIVLTSDDIGILVSSHALLYTIGRLLFGMASDRYSKVALLLLGLVTCAACSVGLAFSNHLWQMLIAMMLLGIVQ 109
Cdd:TIGR00895 40 APAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGL 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 110 GAGWVPATLLVQSWYSKSTYGTMFSILACG--------STFAGILQPfskKFYWRNVELYTGAG---MLVF-------SI 171
Cdd:TIGR00895 120 GGLMPNLNALVSEYAPKRFRGTAVGLMFCGypigaavgGFLAGWLIP---VFGWRSLFYVGGIApllLLLLlmrflpeSI 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 172 VCFIVLREDNVSP--------KQTEDDEEPNPEKKKKGGLRTIV----------GSIVIWHISFVYLFTMEMRTiceTWV 233
Cdd:TIGR00895 197 DFLVSKRPETVRRivnaiapqMQAEAQSALPEQKSTQGTKRSVFkalfqgktarITVLLWLLYFMLLVGVYFLT---NWL 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 234 QLFLTDSKISPD---AFQITYEIGGLVGTMASGIVIDlatrKFDvdatRRVIAVSYTCLMMFSAAGIFEFAE--LSSIFG 308
Cdd:TIGR00895 274 PKLMVELGFSLSlaaTGGALFNFGGVIGSIIFGWLAD----RLG----PRVTALLLLLGAVFAVLVGSTLFSptLLLLLG 345
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1831518188 309 FLAGMFVNGSINVWCMIASQAGFSKIQGTVSAFISFIASSGSMLAGTPLAYLI 361
Cdd:TIGR00895 346 AIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGYLL 398
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
28-385 |
1.58e-10 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 62.64 E-value: 1.58e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 28 TLLPLIREEIVLTSDDIGILVSSHALLYTIGRLLFGMASDRYSKVALLLLGLVTCAACSVGLAFSNHLWQMLIAMMLLGI 107
Cdd:cd17475 17 ALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGA 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 108 VQGAGWVPATLLVQSWYSKSTYGTMFSILACGSTFAG-----ILQPFSKKFYWRNVELYTGAGMLVFSIVCFIVLREDNV 182
Cdd:cd17475 97 GYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGalaaaLLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPPA 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 183 SPKQTEDdeepnpEKKKKGGLRTIVGSIVIWHISFVYLFTMEMRTICETWVQLFLTDS-KISPDAFQITY---EIGGLVG 258
Cdd:cd17475 177 ASAATES------ASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHlGLSVVAAGALLavaQLGGALG 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 259 TMASGIVIDlatrkfDVDATRRViaVSYTCLMMFSAAGIFEFAELSS--------IFGFLAGMFVNGSINVW-CMIASQA 329
Cdd:cd17475 251 RIGLGRVSD------RVFGGRRR--PVLVITAAIAAAALLVLSLLSPgtplwllvLLLILLGLFAIGWNGLYlTLVAESA 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1831518188 330 GFSKIqGTVSAFISFIASSGsMLAGTPL-AYLI-SVFGWKVFLYIFSVQLVIVLFVSS 385
Cdd:cd17475 323 GPEQA-GTALGLANTINFIG-IAIGPPLfGLLVdATHSYAPAWLALALLLVLAALLLL 378
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
28-389 |
5.32e-10 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 60.68 E-value: 5.32e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 28 TLLPLIREEIVLTSDDIGILVSSHALLYTIGRLLFGMASDRYSKVALLLLGLVTCAACSVGLAFSNHLWQMLIAMMLLGI 107
Cdd:cd17365 20 FVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 108 VQGAGWVPATLLVQSWYSKSTYGTMFSILACGSTFAGILQPFS-----KKFYWRNVeLYTGAGMLVFSIVCFivlrednv 182
Cdd:cd17365 100 GLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLaaaliPAFGWRSV-FLLGGVPPLILLPLL-------- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 183 spkqteddeepnpekkkkgglrtiVGSIVIWHISFVYLFTMEMRTiceTWVQLFLTDSKISPDA---FQITYEIGGLVGT 259
Cdd:cd17365 171 ------------------------RGTLLLWVTFFMGLLLVYLLN---SWLPKLMVEAGYSLSQaltITLLLNIGGVIGS 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 260 MASGIVIDlatrKFDVdatRRVIAVSYTCLMMFSAAGIFEFAELS--SIFGFLAGMFVNGSINVwcMIASQAGF--SKIQ 335
Cdd:cd17365 224 LLLGWLAD----RFGP---KRVLALFFALGAVSLALLGVSPASLVllYVLVFLAGACVNGAQVG--LYALAARFypTEVR 294
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1831518188 336 GTVSAFISFI----ASSGSMLAGTPLAYLISVFGwkVFLYIFSVQLVIVLFVSSFRVR 389
Cdd:cd17365 295 ATGVGWALGVgrlgAILGPLLGGLLLAAGLGPES--VFLALAIPAALGALAVLLLRLR 350
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
29-365 |
5.39e-10 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 60.65 E-value: 5.39e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 29 LLPLIREEIVLTSDDIGILVSSHALLYTIGRLLFGMASDRYSKVALLLLGLVTCAACSVGLAFSNHLWQMLIAMMLLGIV 108
Cdd:cd17478 18 LLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 109 QGAGWVPATLLVQSwYSKSTYGTMFSILACGSTFAGILQPFSKKFYwrnVELYTGAGMLVFSI---VCFIVLREDNVSPK 185
Cdd:cd17478 98 SAAFHPEGARLASQ-AAGGRRGLAMSIFSVGGNLGFALGPLIAAAL---VALFGGLGLLILLIipgLAVALLLLRLRPLK 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 186 QTEDDEEPNPEKKKKGGLRTIVGSIVIWHISFV-YLFTMEMRticeTWVQLFLTDSKISPDAFQIT---YEIGGLVGTMA 261
Cdd:cd17478 174 KPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLrSWVLSSLT----TFLPFYLVQRGYSLVFAGLLlslFLFAGAIGTLI 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 262 SGIVIDlatrKFDvdaTRRVIAVSYTCLMMFSAAGIFEFAELSSIFGFLAGMFVNGSINVwCMIASQAGFSKIQGTVSAF 341
Cdd:cd17478 250 GGPLSD----RFG---RRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPV-TVVLAQELLPGNVGLASGL 321
|
330 340
....*....|....*....|....
gi 1831518188 342 ISFIASSGSMLAGTPLAYLISVFG 365
Cdd:cd17478 322 MMGLSFGLGGIGAPVLGALADAFG 345
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
28-149 |
1.87e-09 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 58.67 E-value: 1.87e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 28 TLLPLIREEIVLTSDDIGILVSSHALLYTIGRLLFGMASDRYSKVALLLLGLVTCAACSVGLAFSNHLWQMLIAMMLLGI 107
Cdd:COG0477 35 VALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGI 114
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1831518188 108 VQGAGWVPATLLVQSWYSKSTYGTMFSILACGSTFAGILQPF 149
Cdd:COG0477 115 GAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPL 156
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
27-386 |
3.99e-09 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 57.97 E-value: 3.99e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 27 ITLLPLIREEIVLTSDD---IGILVSSHALLYTIGRLLFGMASDRYSKVALLLLGLVTCAACSVGLAFSNHLWQMLIAMM 103
Cdd:cd17330 16 FPVLPFYVREFNKLGASgyyVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARF 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 104 LLGIVQGAGWVPATLL---VQSWYSKSTYGTMFSILACGSTFAGILQPFSKKFYWRNVELYTGAGMLVFSIVCFIVLred 180
Cdd:cd17330 96 LDGLTGGNVSVAQAYIadiTDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFF--- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 181 nvspkqteddeepnpekkkkggLRTIVGSIViwhISFVYLFTMEMrtICETWVQLFLTDSKISPDAFQITYEIGGLVGTM 260
Cdd:cd17330 173 ----------------------LPPLRRLLL---VYFLIALAFAG--LESVFSLFLKDRFGFSPSQIGLLLALVGIAGIL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 261 ASGIVIDLATRKFDvdaTRRVIAVSytCLMMFSAAGIFEFAELSSIFGFLAGMFVNGSINVW---CMIASQAGFSKIQGT 337
Cdd:cd17330 226 AQLLLIPRLAKRLG---ERKLLRLG--LLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFpalSALLSKSVPSKEQGK 300
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1831518188 338 VSAFISFIASSGSMLAGTPLAYLISVFGWKVFLYIFSVQLVIVLFVSSF 386
Cdd:cd17330 301 AQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
7-178 |
1.00e-08 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 56.80 E-value: 1.00e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 7 IKFVVVTIIYFAHIYFRRLPITLLPLI-REEIVLTSDDIGILVSSHALLYTIGRLLFGMASDRYSK--VALLLLGLVTCA 83
Cdd:COG2271 180 LRFWLLALAYFLVYFALYGFLTWLPTYlVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAA 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 84 ACSVGLAFSNHLWQMLIAMMLLGIVQGAGWVPATLLVQSWYSKSTYGTMFSILACGSTFAGILQPF-----SKKFYWRNV 158
Cdd:COG2271 260 LALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLlvgylLDATGYQAA 339
|
170 180
....*....|....*....|
gi 1831518188 159 eLYTGAGMLVFSIVCFIVLR 178
Cdd:COG2271 340 -FLLLAALALLAALLALLLL 358
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
14-353 |
1.17e-08 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 56.56 E-value: 1.17e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 14 IIYFAHIYFRRLPITLLPLIREEIVLTSDDIGILVSSHALLYTIGRLLFGMASDRYSKVALLLLGLVTCAACSVGLAFSN 93
Cdd:cd17333 3 ISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 94 HLWQMLIAMMLLGIVQGAGWVPATLLVQSWYSKSTYGTMFSILACGSTFAGILQPFSKKFYWRNVELYTG-AGMLVFSIV 172
Cdd:cd17333 83 SIYLFVVLMFLAGLGAGILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAyLIIGLIYLL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 173 CFIVLREDNVSPKQTEDDEEPNPEKKKKGGLRTIvGSIVIWHISFVYLFTMEMRTICETWVQLFLTDSKISPDAFQITYE 252
Cdd:cd17333 163 LAILILLTLFPELPSARNPQQSVGAFSASASRLL-RNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 253 IGGLVGTMASGIVIDLATRKFDVdATRRVIAVSYTCLMMFSAAGIFEFAELS----SIFGFLAGMFVNGSInvwcmIASQ 328
Cdd:cd17333 242 SGFWVGITIGRLLGGPISRRIKP-HTLLVLSGSGALLGLLILLLAPTLVVGLvataLLGLFMAALFPTILS-----LGIS 315
|
330 340
....*....|....*....|....*
gi 1831518188 329 AgFSKIQGTVSAFISFIASSGSMLA 353
Cdd:cd17333 316 N-LPYAKGKGTSVLLAAGSIGGAII 339
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
41-388 |
8.76e-08 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 54.20 E-value: 8.76e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 41 SDDIGILVSSHALLYTIGRLLFGMAS-------DRYSKVALLLLGLVTCAACSVGLAFSNHLWQMLIAMMLLGIVQ-GAG 112
Cdd:cd17355 30 IAEFGWSRAVISLAFTVGLLAFGLAQpfvgrllDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGaGTL 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 113 WVPATLLVQSWYSKSTYGTMFSILACGSTFAGIL-----QPFSKKFYWRNVELYTGAGMLVFSIVCFIVLREDNVSPKQT 187
Cdd:cd17355 110 AAVAFATVAAWWFERRRGLALGILTAGGGLGSLVflplgAALIEAFGWRTALLVLALLALLVLVPVLLLLRRRPADLALR 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 188 EDDEEPNPEkkKKGGLRTIVGSIVIWHIS---FVYLFTMEMRTicetwVQL--FLTDSKISPDAFQITYEIGGL---VGT 259
Cdd:cd17355 190 AYDDASPAS--PGSTLKEALRSASFWLLAlafFLCGFAVVGLI-----VHLvpYLADRGISPAAAAVALALIGLfniVGR 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 260 MASGIVIDLATRkfdvdatRRVIAVSY------TCLMMFSAAGIFEFAELSSIFGFLAGMFVNGSInvwcMIASQAGFSK 333
Cdd:cd17355 263 LLSGWLGDRYSP-------RRLLAASYalralgLALLLLLPFPPLALLLFAALFGLGWGATVPLTA----ALAARYFGAR 331
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1831518188 334 IQGTVSAFISFIASSGSMLAGTPLAYLISVFGWKVFLYIFSVQLVIVLFVSSFRV 388
Cdd:cd17355 332 SYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVLPI 386
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
27-381 |
9.20e-08 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 53.85 E-value: 9.20e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 27 ITLLPLIREEIVLTSDDIGILVSSHALLYTIGRLLFGMASDRYSKVALLLLGLVTCAACSVGLAFSNHLWQMLIAMMLLG 106
Cdd:cd17371 19 GLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 107 IVQGAGWVPATLLV-QSW---YSKSTYGTMFSILACGSTFAGILQP-----FSKKFYWRnvelytgaGMLVFSIV-CFIV 176
Cdd:cd17371 99 LGFGGEWAAGAALMaEYVparHRGKALGYVQSGWAVGWLLATLLAAllfplLPPEIAWR--------VLFLLGALpALLV 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 177 L--REDNVSPKQTEDDEEPNPEKKKKGGLR----------TIVGSIVIWHISFVYLFTMemrticeTWVQLFLTD----S 240
Cdd:cd17371 171 LfiRRFVKEPPQWQAARAARRHFADRPSLRelfsppllrtTLLASLLATGALGGYYGIT-------TWLPSYLTGerglS 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 241 KISPDAFQITYEIGGLVGTMASGIVIDLATRkfdvdatRRVIAVsYTCLMMFSAAGIFEFA---ELSSIFGFLAGMFVNG 317
Cdd:cd17371 244 FEGSAGYLVVTILGGFLGYLAGGFLADRIGR-------RNNFAL-FALGSAISILLYFFLPlspTLILILGFPLGFFASG 315
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1831518188 318 SINVWCMIASQAGFSKIQGTVSAFI----SFIASSGSMLAG-----TPLAYLISVFGWkvFLYIFSVQLVIVL 381
Cdd:cd17371 316 PFSGMGAYLTELFPTAVRATAQGFCynvgRIIGALFPFLVGflatsGSLGTAIAVFAA--VYYIAGLVLALLL 386
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
29-179 |
1.11e-07 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 53.46 E-value: 1.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 29 LLPLIREEIVLTSDDIGILVSSHALLYTIGRLLFGMASDRYSKVALLLLGLVTCAACSVGLAFSNHLWQMLIAMMLLGIV 108
Cdd:cd06180 21 LLPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAA 100
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1831518188 109 QGAGWVPATLLVQSWYSKSTYGTMFSILACG----STFAGILQPF--SKKFYWRNVELYTGAGMLVFSIVCFIVLRE 179
Cdd:cd06180 101 SAFVFVFGSNLVLHHATAAGRGHLIGLLFAGvglgIALSGLLVPAglGGGLSWRAGWLALALLSAVLLLLSFLLLRR 177
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
30-383 |
1.21e-07 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 53.73 E-value: 1.21e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 30 LPLIREEIVLTSDDIGILVSSHALLYTIGRLLFGMASDRYSKVALLLLGLVTCAACSVGLAFSNHLWQMLIAMMLLGIVQ 109
Cdd:cd17320 22 LPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 110 GAGWVPATLLVQSWYSKSTYGTMFSIL--------ACGSTFAGILQPFskkFYWRNVELYTGAGMLVFSIVCFIVLREdn 181
Cdd:cd17320 102 AAGSVVARAIVRDLYSGAELAKIFSLLmmilaiapALAPLLGGLLLLF---FGWRAIFVFLALLGLLLLLLVLLFLPE-- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 182 vspKQTEDDEEPNPeKKKKGGLRTIVGSIVIWHISFVYLFTMEMRTICET-WVQLFLTDSKISPDAFQITYeIGGLVGTM 260
Cdd:cd17320 177 ---TLPEEKRKPLL-SSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAaAPFIYIEQLGLSPAQFGLLF-ALNAIALI 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 261 ASGIVIDLATRKFDVDAT-RRVIAVSYTCLMMFSAAGIFEFAELSSIFGFLAG-MFVNGSINVWCMIASQAGFSKIQGTV 338
Cdd:cd17320 252 LGSLLNGRLVRRFGPRRLlRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLiFFGFGLIFPNATSLALEPFPHVAGTA 331
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1831518188 339 SAFISFIASSGSMLAGTPLAYLISVFGWKVFLYIFSVQLVIVLFV 383
Cdd:cd17320 332 SALLGFLQFLIGALAGALVGLLPNGTALPMGLLILVLGLLALLLL 376
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
10-188 |
3.67e-07 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 51.83 E-value: 3.67e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 10 VVVTIIYFAHIYfrrLPITLLPLIREEIVLTSDDIGILVSSHALLYTIGRLLFGMASDRYSKVALLLLGLVTCAACSVGL 89
Cdd:cd17489 2 LLANFFFFLSFY---LLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 90 AFSNHLWQMLIAMMLLGIVQGAGWVPATLLVQSWYSKSTYGTMFSILACGSTFAGILQPFSKKFYWRNVELY----TGAG 165
Cdd:cd17489 79 LLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAvlfiVAAV 158
|
170 180
....*....|....*....|...
gi 1831518188 166 MLVFSIVCFIVLREDNVSPKQTE 188
Cdd:cd17489 159 LALLALLLVFLVKDPPPVAAEEA 181
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
30-149 |
3.86e-07 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 51.79 E-value: 3.86e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 30 LPLIREEIVLTSDDIGILVSSHALLYTIGRLLFGMASDRYSKVALLLLGLVTCAACSVGLAFSNHLWQMLIAMMLLGIvQ 109
Cdd:cd17321 19 LPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGI-G 97
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 1831518188 110 GAGWVPATL-LVQSWYSKSTYGTMFSILACGSTFAGILQPF 149
Cdd:cd17321 98 AAAIMPASLaLIAATFPGERRGRALGLWGAVVGIGAALGPL 138
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
29-351 |
4.54e-07 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 51.87 E-value: 4.54e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 29 LLPLIREEIVLTSDDIGILVSSHALLYTIGRLLFGMASDRYSKVALLLLGLVTCAACSVGLAFSNH-LWQMLIAMMLLGI 107
Cdd:cd17341 21 LGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAVSsYWGLLVLGFLLGF 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 108 VqGAGWVPATLLVQSWYSKSTYGTMFSILA----CGSTFAGILQP--------FSKKFYWRNVELYTGAGMLVFSIVCFI 175
Cdd:cd17341 101 A-GANFASGQPWASFWFPKEKIGGAAGGIAgagnMGVAVSQLLAPliagaivfDGGFVGWRNAFFVPGILLAIAAVLVLL 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 176 VLREDNVSpkqteddeePNPEKKKKGGLRTIVGSIVIWHISFVYLFTMEMRTICETWVQLFLTDSkispdaFQITYEIGG 255
Cdd:cd17341 180 FGDDLPTG---------KASALEFLKVQLAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTR------FGLPLVTAG 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 256 LVgtMASGIVIDLATRKF-----DVDATRRVIAVSYTCLMMFSAA-GIFEFAELSSIFGFLAGMFVngsinvwCMIASQA 329
Cdd:cd17341 245 IL--AALFPLAGALARPAggwlsDRFGGRRRLWWLFIVMTIGAALlSLSLPTSGTNLVLFLALFVA-------LGLGAGA 315
|
330 340
....*....|....*....|....
gi 1831518188 330 GFskiqGTVSAFISFI--ASSGSM 351
Cdd:cd17341 316 GN----GSVFRMVPFIfrRELGAV 335
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
22-111 |
4.80e-07 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 51.78 E-value: 4.80e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 22 FRRLPITLLPLIREEIVLTSDDIGILVSSHALLYTIGRLLFGMASDRYSKVALLLLGLVTCAACSVGLAFSNHLWQMLIA 101
Cdd:cd17370 214 LGNFSFAFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLG 293
|
90
....*....|
gi 1831518188 102 MMLLGIVQGA 111
Cdd:cd17370 294 FILWGLYMGA 303
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
29-179 |
7.98e-07 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 51.08 E-value: 7.98e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 29 LLPLIREEIVLTSDDIGILVSSHALLYTIGRLLFGMASDRYSKVALLLLGLVTCAACSVGLAFSNHLWQMLIAMMLLGIV 108
Cdd:cd17328 21 VLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIG 100
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1831518188 109 QGAGWVPATLLVQSWYSKSTYGTMFSILA----CGSTFAGILQP-FSKKFY-WRNVELYTGAGMLVFSIVCFIVLRE 179
Cdd:cd17328 101 EASYSPIAPTIIADLFPKEKRTRALGVFYfaipLGSGLGYVVGGlVAQATGgWRWAFRVTGVLGVLLAILLLLFVRE 177
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
3-148 |
2.36e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 49.34 E-value: 2.36e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 3 FKTHIKFVVVTIIYFAHIYFrrLPITLLPLIREEIVLTSDDIGILVSSHALLYTIGRLLFGMASDRYSKVALLLLGLVTC 82
Cdd:pfam07690 198 LRDPVLWLLLALLLFGFAFF--GLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLL 275
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1831518188 83 AACSVGLAFSNHLWQ---MLIAMMLLGIVQGAGWVPATLLVQSWYSKSTYGTMFSILACGSTFAGILQP 148
Cdd:pfam07690 276 ILAALGLLLLSLTLSslwLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
27-175 |
5.50e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 48.38 E-value: 5.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 27 ITLLPLI-REEIVLTSDDIGILVSSHALLYTIGRLLFGMASDRYSKVALLLLGLVTCAACSVGLAFSNHLWQMLIAMMLL 105
Cdd:cd06173 228 TVLLPLLaKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLL 307
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1831518188 106 GIVQGAGWVPATLLVQSWYSKSTYGTMFSIL--------ACGSTFAGILQPFskkFYWRNVELYTGAGMLVFSIVCFI 175
Cdd:cd06173 308 GLAGGLFNVPLNTLLQLRVPDELRGRVFSVYnalnsgamPLGALLAGLLADA---LGLSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
27-383 |
9.43e-06 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 47.55 E-value: 9.43e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 27 ITLLPLIREEIVLTSDDIGILVSSHALLYTIGRLLFGMASDRYSKVALLLLGLVTCAACSVGLAFSNHLWQMLIAMMLLG 106
Cdd:cd17477 16 LPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 107 IVQGAGWVpatlLVQSWYSK-----------STYGTMFSI-LACGSTFAGILQPFSKKFYWrnvelyTGAGMLVFSIVCF 174
Cdd:cd17477 96 IGLAGLFV----VSESWLNAlatnenrgrvlGLYSTVLGLgFALGPLLLALVGTAGALPFL------IAAVLLLLALVPL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 175 IVLRednvspkqtedDEEPNPEKKKKGGLRTIV-GSIVIWHISFVYLFTMemrTICETWVQLFLTDSKISPDA---FQIT 250
Cdd:cd17477 166 LLTR-----------RAAPEIEEAESISLRRLLrIAPLALLGAFVAGFLE---GAFYSLLPLYGLRLGLSVAQaalLLAA 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 251 YEIGGLVGTMASGIVIDLATRkfdvdatRRVIAVSYTCLMMFSAAGIFEFAELSSIFG--FLAGMFVnGSINVWCMIASQ 328
Cdd:cd17477 232 FVLGGLLLQWPLGWLADRFDR-------RRVLLGCALLGALAALLLPLVPGLPLALLVllFLWGGAA-GPLYTLALALAG 303
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1831518188 329 AGFSKIQ-GTVSAFISFIASSGSMLAGTPLAYLISVFGWKVFLYIFSVQLVIVLFV 383
Cdd:cd17477 304 DRLPGDElVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLF 359
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
39-384 |
1.53e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 46.83 E-value: 1.53e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 39 LTSDDIGILVSSHALLYTIGRLLFGMASDRYSKVALLLLGLVTCAACSVGLAFSNHLWQMLIAMMLLGIVQGAGWVPATL 118
Cdd:cd17316 33 LSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGAST 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 119 LVQSWYSKSTYGTMFSILACGSTFAGIL---------QPFSKKFYWRNVeLYTGAGMLVFSivcfIVLRednvspkqted 189
Cdd:cd17316 113 YVAEFAPSKRRGFALGLLQSGWALGALLaalvaslliPLLSGDWGWRIL-FLIGALPALLA----LLLR----------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 190 deepnpekkkkggLRTIVGSIVIWHISFV-YLFTMEMRTICETwvQLFLTDSKISPDAFQITyeIGGLVGTMASGIVIDL 268
Cdd:cd17316 177 -------------RRTLLLILLWFFISFGyYGLTTFLPTYLQT--VLGLSPATSSLYLLLIS--LGALVGALIAGLLSDR 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 269 ATRKfdvdatrRVIAVSytCLMMFSAAGIFEFAELSSIFGFLAGMFVNGSINVWCMIASQAGFS-----KIQGTVSAFIS 343
Cdd:cd17316 240 IGRK-------KTLVIG--LILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAelfptEVRATGVGLSY 310
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1831518188 344 FIASSGSMLAGTPLAYLISVFG-WKVFLYIFSVQLVIVLFVS 384
Cdd:cd17316 311 NLGRLGGGGAPPLIALLLASTGgTGVPALILALLAIVALIVA 352
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
11-150 |
3.27e-05 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 45.91 E-value: 3.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 11 VVTIIYFAHIYfrrlpitllplIREEIVLTSDDIGILVSSHALLYTIGRLLFGMASDRYSKVALLLLGLVTCAACSVGLA 90
Cdd:COG2270 254 VQTVIAFAGIY-----------AAGVLGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAY 322
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1831518188 91 FSNHLWQMLIAMMLLGIVQGAgwvpatllVQSwYSKSTY---------GTMFSILACGSTFAGILQPFS 150
Cdd:COG2270 323 FLTTALAFWILGLLIGLVMGG--------IQA-LSRSLLarlippgreAEFFGLYALSGKAASFLGPLL 382
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
30-317 |
7.20e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 44.87 E-value: 7.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 30 LPLIREEIVLTSD-DIGILVSSHALLYTIGRLLFGMASDRYSKVALLLLGLVTCAACSVGLAFSNHLWQMLIAMMLLGIV 108
Cdd:cd17473 22 LPAIAQHFVPNSElLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIG 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 109 QGAGWVPATLLVQSWYSKSTYGTMFSILACGSTFAGILQPFS----KKFYWRNVELYTGAGMLVFsIVCFIVLREDNVSP 184
Cdd:cd17473 102 VAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLggalAEIGWRAPFLVYLLALPVL-ILVLLFLPEPARKS 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 185 KQTEDDEEPNPEKKKKGGLRTIVGSIVIwHISFVYLFTMEMRTIcetWVQLFLTDSKISPDAFQITyEIGGLVGTMASGI 264
Cdd:cd17473 181 KSAASPGAATAAALPWKRVLPIYFLAFL-AMLLFYVIPIQLPFL---LQERGGGSAALIGLALAIA-SLAGAIGALLFGR 255
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 1831518188 265 VIDLATRkfdvdatRRVIAVSYTCLmmfsAAGIFEFAELSSIFGFLAGMFVNG 317
Cdd:cd17473 256 LKRRLGK-------RRLLAIGFALM----ALGFLLLALASGLWVVLLGAILAG 297
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
9-175 |
7.55e-05 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 44.85 E-value: 7.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 9 FVVVTIIYFA-HIYfrrlpITLLPL-IREEIVLTSDDIGILVSSHALLYTIGRLLFGMASDRYSKVALLLLGLVTCAACS 86
Cdd:cd17471 205 FAAFTLLFAAnSMY-----IIAMPLyVTNELGGSESWVGLLFGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAGVLFY 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 87 VGLAFSNHLWQMLIAMML----LGIVQGAG--WVPATLLVQSWYSKSTYGTMFSI--LACGSTFAGILQPFSkkfyWRNV 158
Cdd:cd17471 280 LGLALATSLWQLIALQLLnaifIGITAGLGisYFQDLMPGQPGLATTLYSNASRIgsLLGGLLAGVIAQYFG----YRAV 355
|
170
....*....|....*..
gi 1831518188 159 eLYTGAGMLVFSIVCFI 175
Cdd:cd17471 356 -FLVCAVLALLALVLLL 371
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
43-387 |
2.06e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 43.37 E-value: 2.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 43 DIGILVSSHALLYTIGRLLFGMASDRYSKVALLLLGLVTCAACSVGLAFSNH-----LWQMLIAMMLLGIVQGAGW---- 113
Cdd:cd06173 35 LVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALlgslsLWLLLVLAFLLGIASAFFGparq 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 114 ------VPATLLVQ--SWYSKSTYGTMFSILACGSTFAGILQPFSkkFYWRNVELYTGAGMLVFSIVcfivlrednVSPK 185
Cdd:cd06173 115 allpelVPKEQLVRanALNSLATQLARIIGPALGGLLVALLGPGG--AFAINALSFLLSALLLLFIR---------RPPP 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 186 QTEDDEEPNPEKKKKGGLRTIVGSIVIWHI----SFVYLFTMEMRTICETWVQLFLTDSKISPDAFQITYEIGGLVGTMa 261
Cdd:cd06173 184 AAPGESSSLLLRDLREGLRYLRRSPLLRLLllalALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGAL- 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 262 sgividLATRKFDVDATRRVIAVSYTCLMMFSAAgifeFAELSSIFGFLAGMFVNGSINVWCMIASQAGF-----SKIQG 336
Cdd:cd06173 263 ------LLGRLSKRRRRGRLLLIGALLLGLALLV----LGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLqlrvpDELRG 332
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1831518188 337 TVSAFISFIaSSGSMLAGTPLA-YLISVFGWKVFLYIFSVQLVIVLFVSSFR 387
Cdd:cd06173 333 RVFSVYNAL-NSGAMPLGALLAgLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
57-101 |
2.75e-04 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 42.96 E-value: 2.75e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 1831518188 57 IGRLLFGMASDRYSKVALLLLGLVTCAACSVGLAFSNHLWQMLIA 101
Cdd:PRK11043 56 LGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVL 100
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
9-121 |
4.37e-04 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 42.18 E-value: 4.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 9 FVVVTIIYFAHIYFRRLPITLLPLIREEIVLTSDDIGILVSSHALLYTIGRLLFGMASDRYSKVALLLLGLVTCAACSVG 88
Cdd:cd17473 200 LPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLL 279
|
90 100 110
....*....|....*....|....*....|...
gi 1831518188 89 LAFSNHLWQMLIAMMLLGIvqGAGWVPATLLVQ 121
Cdd:cd17473 280 LALASGLWVVLLGAILAGL--GFGLLLPTLNSW 310
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
43-179 |
4.72e-04 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 42.39 E-value: 4.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 43 DIGILVSSHALLYTIGRLLFGMASDRYSKVALLLLGLVTCAACSVGLAF----SNHLWQMLIAMMLLGIVQGAGWVPATL 118
Cdd:PRK11273 64 DLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFvpwaTSSIAVMFVLLFLCGWFQGMGWPPCGR 143
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1831518188 119 LVQSWYSKSTYGTMFSILACGSTFAGILQP--FSKKFYWRN---VELYTGA-GMLVFSIVCFIVLRE 179
Cdd:PRK11273 144 TMVHWWSQKERGGIVSVWNCAHNVGGGLPPllFLLGMAWFNdwhAALYMPAfAAILVALFAFAMMRD 210
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
57-176 |
5.16e-04 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 42.31 E-value: 5.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 57 IGRLLFGMASDRYSKVALLLLGLVTCAACSVGLAFSNHLWQMLIAMMLLGIVQGAGWVPATLLVQSWYSKSTYGTmFSIL 136
Cdd:TIGR00898 142 LGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAI-VGTL 220
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1831518188 137 AC-GSTFAGILQPFSKKF--YWRNVELYTGAGMLVFSIVCFIV 176
Cdd:TIGR00898 221 IQvFFSLGLVLLPLVAYFipDWRWLQLAVSLPTFLFFLLSWFV 263
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
29-122 |
5.26e-04 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 42.43 E-value: 5.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 29 LLPLI-REEIVLTSDDIGILVSSHALLYTIGRLLFGMASDRYSKVALLLLGLVTCAACSVGLAFSNHLWQMLIAMMLLgi 107
Cdd:pfam05977 240 LLPLVaRDLLDGDAIFYGILLGAVGVGAILGALSLPRLRERLGSDRLVLLASVVTALVLLSLALAPNLWLAIPVLLLG-- 317
|
90
....*....|....*
gi 1831518188 108 vqGAGWVPATLLVQS 122
Cdd:pfam05977 318 --GAAWITALTTLNV 330
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
3-177 |
6.94e-04 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 41.79 E-value: 6.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 3 FKTHIKFVVVTIIYFAHIYFRRLPITLLPLI-REEIVLTSDDIGILVSSHALLYTIGRLLFGMASDRYSKVALLLLGLVT 81
Cdd:cd17319 175 WFYLRQVWGLALGYFGINYALYGLLTWLPTYlKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVIIIG 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 82 CAACSVGLAFSNHLWQMLIAMMLLGIVQ---GAGWVPATLLVQSWYSKSTYGTMFSILACGSTFAGILQPFSKKFywrnV 158
Cdd:cd17319 255 LLLAAVGLLLAYLTTSPVVAVILLSLAGfgiGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGY----L 330
|
170
....*....|....*....
gi 1831518188 159 ELYTGAGMLVFSIVCFIVL 177
Cdd:cd17319 331 VDATGSYTAAFLFLAAVAL 349
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
31-358 |
7.96e-04 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 41.49 E-value: 7.96e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 31 PLIREEIVLTSDDIGILVSSHALLYTIGRLLFGMASDRYSKVALLLLGLVTCAACSVGLAFSNHLWQMLIAMMLLGIVQG 110
Cdd:PRK11551 39 PRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLG 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 111 AGWVPATLLVQSWYSKSTYGTMFSILACGSTFAGILQPFSKKF-----YWRNVELYTGAGMLVFSIVCFIVLREDNVSPK 185
Cdd:PRK11551 119 GALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLaagdaAWRHIFYVGGVGPLLLVPLLMRWLPESRAFAQ 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 186 QTEddeepnPEKKKKGGLRTIVG------SIVIWhISfvYLFTMEMRTICETWVQLFLTDSKIS-PDA--FQITYEIGGL 256
Cdd:PRK11551 199 AAG------AGKQRAPVLRALFGegrataTLLLW-IS--YFFTLIVLYFLLNWLPSLLVGQGLSrSQAglVQIAFNIGGA 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 257 VGTMASGIVIDLATRKFDVDATRRVIAVSYTCLMMFSAAGIFEFAelssifGFLAGMFVNGSINVWCMIASQAGFSKIQG 336
Cdd:PRK11551 270 LGSLLIGALMDRLRPRRVVLLIYAGILASLAALAAAPSFAGMLLA------GFAAGLFVVGGQSVLYALAPLFYPTQVRG 343
|
330 340
....*....|....*....|....*.
gi 1831518188 337 T-VSAFISF--IAS-SGSMLAGTPLA 358
Cdd:PRK11551 344 TgVGAAVAVgrLGSmAGPLLAGQLLA 369
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
39-149 |
8.74e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 41.43 E-value: 8.74e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 39 LTSDDIGILVSSHALLYTIGRLLFGMASDRYSKVALLLLGLVTCAACSVGLAFS--NHLWQMLIAMMLLGIVQGAGWVPA 116
Cdd:COG2211 261 LSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLgpGNLWLLLVLAALAGIGLGAILVLP 340
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 1831518188 117 TLLV-------QSWYSKSTYGTMFSILACGSTFAGILQPF 149
Cdd:COG2211 341 WAMLadvvdydEWKTGRRREGLYFGIFTFAIKLGQALAGA 380
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
1-317 |
1.04e-03 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 41.19 E-value: 1.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 1 MSFKTHIK-FVVVTIIYFAHIYFRRLPITLLPLIREEIVLTSDDIGILVSSHALLYTIGRLLFGMASD-RYSKVALLLLg 78
Cdd:PRK09556 22 MWFKPFMQsYLVVFIGYLTMYLIRKNFKAAQNDMISTYGLSTTELGMIGLGFSITYGVGKTLVGYYADgKNTKQFLPFL- 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 79 LVTCAACSVGL-----AFSNHLWQMLIAMMLLGIVQGAGWVPATLLVQSWYSKSTYGTMFSILAC----GSTFAGILQPF 149
Cdd:PRK09556 101 LILSAICMLGFgaslgSGSVSLGLMIALWALSGFFQSTGGPCSYSTITRWTPRRKRGRFLGFWNIshnlGGAGAGGVALW 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 150 -SKKFYWRNVelytgAGMLVF-SIVCFIV----LREDNVSPK--------------QTEDDEEPNPEKKKKGGL--RTIV 207
Cdd:PRK09556 181 gANYFFDGHV-----IGMFIFpSIIALIIgfigLRYGSDSPEelgwgkaeeifgepISEEDKETESTDMTKWQIfvEYVL 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 208 GSIVIWHISFVYLFTMEMRTICETWVQL-------FLTDSKISPDAFqitYEIGGLVGTMASGIVIDLATrkfdvdaTRR 280
Cdd:PRK09556 256 KNPVIWLLCFANIFLYIVRIGIDNWSPVyafqelgFSKEDAINTFTL---FEIGALVGSLLWGWLSDLAN-------GRR 325
|
330 340 350
....*....|....*....|....*....|....*..
gi 1831518188 281 VIaVSYTCLMMFSAAgIFEFAELSSIFGFLAGMFVNG 317
Cdd:PRK09556 326 AL-VACIALALIIFT-LGVYQHATSEYMYLASLFALG 360
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
60-390 |
1.17e-03 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 41.45 E-value: 1.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 60 LLFGMA---SDRYSK------VALLLLGLvTCAACsVGLAFSNHlWQMLIAMMLLGiVQGAGWVPATL-LVQSWYSKSTY 129
Cdd:PRK08633 62 LLSSPAgflADKFSKnrviriVKLFEVGL-TLLIV-LAYYLGWF-WLAFAVTFLLG-AQSAIYSPAKYgIIPELVGKENL 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 130 GT------MFSILAC------GSTFAGILQPFSKKFYWRNVeLYTGAGMLVFSIVCFIV-LREDNVSPkqtEDDEEPNPE 196
Cdd:PRK08633 138 SRanglleAFTIVAIlagtalFSFLFESVNGNTPSEILGRI-APAGLVLLAVAVLGLIFaYRLPKVPA---AAPEVFDKK 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 197 KKKKGGL---------------RTIVGSIVIWHISFVYL-----FTMEmrticetwvQLFLTDskispdafqiTYEIGGL 256
Cdd:PRK08633 214 KYLFPKLlwrnlkllrsdrvlwLAIIGLSYFWFISQLAQanfpaYAKE---------VLGLDN----------TFQVQYL 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 257 VGTMASGIVID--LATR--KFDVDATrrVIAVS----YTCLMMFSAAGIFEFAELSS-IFGFLAGMFVngsINVWCMIAS 327
Cdd:PRK08633 275 LAASAIGIGIGslLAGRlsGRHIELG--LVPLGalglALSLFLLPTAPSLASVLVLFfLFGFSAGLFI---VPLNALIQF 349
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1831518188 328 QAGfSKIQGTVSAFISFIASSGsMLAGTPLAYLISVFGWKVfLYIFSVQLVIVLFVSSFRVRL 390
Cdd:PRK08633 350 RAP-EKELGKVLAANNFLQNVG-MLLFLALTTLFSGLGLSP-AGLFYLIALVTLIGTLYTLLL 409
|
|
| PRK03699 |
PRK03699 |
putative transporter; Provisional |
74-238 |
1.55e-03 |
|
putative transporter; Provisional
Pssm-ID: 235151 [Multi-domain] Cd Length: 394 Bit Score: 40.68 E-value: 1.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 74 LLLLGLVTCAACSVGLAFSNHLWQMLIAMMLLGIVQGAGWVPATLLVQSWYSKSTYGTMFSILACGSTFAGILQP----- 148
Cdd:PRK03699 74 QLIFGFALMILAVAGLMFSHSLALFSIAMFVLGVVSGITMSIGTFLITHVYEGKQRGSRLLFTDSFFSMAGMIFPiiaay 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 149 -FSKKFYWRNVELYTG---AGMLVFSIVC-FIVLREDNvspkqtedDEEPNPEKKKKGGLRTIVGSIVIwhisFVYLFTM 223
Cdd:PRK03699 154 lLARSIEWYWVYACIGlvyVAIFILTLFSeFPALGKHA--------PKADKPVAKEKWGIGVLFLAIAA----LLYILAQ 221
|
170
....*....|....*
gi 1831518188 224 EMRTiceTWVQLFLT 238
Cdd:PRK03699 222 LTFI---SWVPEYAQ 233
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
3-110 |
1.59e-03 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 40.63 E-value: 1.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 3 FKTHIKFVVVTIIYFAHIYFRRLPITLLP-LIREEIVLTSDDIGILVSSHALLYTIGRLLFGMASD-RYSKVALLLLGLV 80
Cdd:cd17474 194 ALRGRGLLTFLVSAFLYFFLYFAFLTYLPfLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKkRFGARRILVIGLL 273
|
90 100 110
....*....|....*....|....*....|
gi 1831518188 81 TCAACSVGLAFSNHLWQMLIAMMLLGIVQG 110
Cdd:cd17474 274 LYALSLLLLGFVPSLALLLIAIVLFGLGLG 303
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
57-178 |
2.03e-03 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 40.26 E-value: 2.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 57 IGRLLFGMASDRYSKVALLLLGLVTCAACSVGLAFSNHLWQMLIAMMLLGIVQGAGWVPATLLVQSW---YSKSTYGTMF 133
Cdd:cd17317 40 IGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIvgpKYRSFVGILF 119
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1831518188 134 SI-LACGSTFAGILQPFSKkfYWRNVELYTGAGMLVFSIVCFIVLR 178
Cdd:cd17317 120 GLfWALGYMLLALLAYLIR--DWRWLQLAISLPGLLFLLLLWWLPR 163
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
10-177 |
2.59e-03 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 40.30 E-value: 2.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 10 VVVTIIYFAHIYFRRLPITLLPLIREEIvLTSDDIGILVSSHALLYTIGRLLFGMASD----RYSKVALLLLGLVTCAAC 85
Cdd:cd06179 1 AALCLAYFAQLFGVTLPAAVLPFIVADL-GPSSNSTWISTAWSLAQAVLGPIVGRLSDlfgrRWFFIGGNLLGVVGSIVA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 86 SVGLAFSnhlwQMLIAMMLLGIVQGA----GWVPATLLVQSWYSKsTYGTMFSILACGSTFAGIL-QPFSKKFY--WRNV 158
Cdd:cd06179 80 GTAKSVN----MLIGGQALIGIGAGTqglgAAVASELVPNKYRGL-VQGVVNLVASPGSALGPLIaGALVEANAagWRWI 154
|
170
....*....|....*....
gi 1831518188 159 eLYTGAGMLVFSIVCFIVL 177
Cdd:cd06179 155 -FYINAIFNALALILLFFF 172
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
44-365 |
2.69e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 39.89 E-value: 2.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 44 IGILVSSHALLYTIGRLLFGMASDRY-----SKVALLLLGLVTCAACSVGLAFSNH------LWQMLIAMMLLGIVQGAG 112
Cdd:COG2211 48 VGLILLVARLWDAITDPLIGALSDRTrtrwgRRRPWILIGAIPLALSFVLLFTAPDlsptgkLIYALVTYLLLGLAYTLV 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 113 WVP----ATLLVQSWYSK---STYGTMFSILA--CGSTFAGILQPF---SKKFYWRNVELYTGAGMLVFSIVCFIVLRED 180
Cdd:COG2211 128 NIPysalGAELTPDYEERtrlSSWRFAFAGLGglLASVLPPPLVAAfggDAALGYRLTALIFAVLGLLAFLLTFFGTKER 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 181 NVSPKQteddeepnpEKKKKGGLRTIVGSIVIWHISFVYLFTMEMRTICETWVQLFLTDSKISPDAFQITYEIGGLVGTM 260
Cdd:COG2211 208 PVPEEE---------KVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAAL 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 261 ASGIVIDLATRKFDvdaTRRVIAVSYtCLMMFSAAGIFeFAELSSIFGFLAGMFVNG------SINVWCMIASQAGFSKI 334
Cdd:COG2211 279 LGAPLWPRLAKRFG---KKKAFIIGL-LLAALGLLLLF-FLGPGNLWLLLVLAALAGiglgaiLVLPWAMLADVVDYDEW 353
|
330 340 350
....*....|....*....|....*....|....*..
gi 1831518188 335 Q------GTVSAFISFIASSGSMLAGTPLAYLISVFG 365
Cdd:COG2211 354 KtgrrreGLYFGIFTFAIKLGQALAGALAGLLLALFG 390
|
|
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
44-388 |
3.66e-03 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 39.61 E-value: 3.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 44 IGILVSSHALLYTIGRLLFGMASDRYSKVALLLLGLVTCAACS--VGLAFS---NHLWQMLIAMMLLGIVQGAGWVPATL 118
Cdd:cd17344 64 LGALDSAFLFAYAIGMFFSGHIGERLPLRYFLSFGMLLSGLFTalFGLGYYwniHSLWYFVVVQILAGLFQSTGWPSVVA 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 119 LVQSWYSKSTYGTMFSILA--------CGSTFAGILQpfskKFYWRNVELYTGAGMLVFSIVCFIVLREDNvsPKQTEdd 190
Cdd:cd17344 144 CVGNWFGKGKRGLIMGIWNshtsvgniLGSLIAGIFV----SSAWGLSFIVPGIIIAAMGVLVFLFLVEHP--PGVIE-- 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 191 eepnpekkkkgglrtivgsiviwhISFVYLFTMEMRTICETWVQLFLT-----DSKISPDaFQITYEIGGLVGTMASGIV 265
Cdd:cd17344 216 ------------------------FSLCLFFAKLVSYTFLYWLPLYISntailSAKKAGD-LSTLFDVGGIVGGILAGYI 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 266 IDlatrKFDVDATR--RVIAVSYTCLMMFSAAGIFEFAeLSSIFGFLAGMFVNGSinvWCMIA-----------SQAGFS 332
Cdd:cd17344 271 SD----YTGGRATTcaAMLILAAPMLFIYNYFGQVSMT-TNIVLLIVCGLLVNGP---YALITtavsadlgthkSLKGNA 342
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 333 KIQGTVSAFI----SFIASSGSMLAGtplayLISVFGWKVFLYIFSVQLVIVLFVSSFRV 388
Cdd:cd17344 343 RALATVTAIIdgtgSIGAALGPLLAG-----LISSRGWNNVFYMLIAADVCAGLLLTRLV 397
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
29-383 |
3.76e-03 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 39.48 E-value: 3.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 29 LLPLIREEIVLTSDDIGILVSSHALLYTIGRLLFGMASDRYSKVALLLLGLVTCAACSVGLAFSNHLWQMLIAMMLLGIv 108
Cdd:cd17474 21 ILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGI- 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 109 QGAGWVP--ATLLVQSWYSKSTYGTM---FSILACGSTFAGILQPFSKKFYWRNVELYTGAGMLVFSIVCFIVLREdnvs 183
Cdd:cd17474 100 GAAGLGPlaLTLIGDLFEGGERAKAMglyEAALGLGIAVGPLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPE---- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 184 pkqtEDDEEPNPEKKKKGGLRTIVGSIVIWHISFVYLFTMEMRTICETWVQLFLTDS-KISPDAFQITYEIGGLVGTMAS 262
Cdd:cd17474 176 ----PKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLyGISPIIIGLLFAGWSVLLALGS 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 263 GIVIDLATRKFDvdaTRRVIAVSYTC-----LMMFSAAGIFEFAELSSIFGFLAGMfVNGSINVwcMIASQAGfSKIQGT 337
Cdd:cd17474 252 LFVGRLLKKRFG---ARRILVIGLLLyalslLLLGFVPSLALLLIAIVLFGLGLGL-NLPLLTT--LVTELAP-EEERGT 324
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1831518188 338 VSAFISFIASSGSMLAGTPLAYLISVFGWKVFLYIFSVQLVIVLFV 383
Cdd:cd17474 325 ASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVL 370
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
9-127 |
3.84e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 39.51 E-value: 3.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 9 FVVVTIIYFAHIYFRrlpITLLPLIREEIVLTSDDIGILVSSHALLYTIGRLLFGMASDRYSKVALLL-LGLVTCAACSV 87
Cdd:cd17490 1 FLIIVFLFWFSQYVY---VPFLSPYAESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFIiIGLLFTVLASL 77
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 1831518188 88 GLAFSNHLWQMLIAMMLLGIVqGAGWVPATLLVQSWYSKS 127
Cdd:cd17490 78 IMILFPSPWGLLIARFLSGIA-AATWVSFTVLYASYFPPD 116
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
44-315 |
6.76e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 38.75 E-value: 6.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 44 IGILVSSHALLYTIGRLLFGMASDRYSKVALLLLGLVTCAACSVGLAFSNHLWQMLIAMMLLGIVQGAGWVPATLLVQSW 123
Cdd:cd17329 37 VGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADV 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 124 YSKSTYGTMFSIL--------ACGSTFAGILQPFSKkfywrNVELYTGAGMLVFSIVCFIVLREDNVSPKQteddeePNP 195
Cdd:cd17329 117 TTPENRTRAFSLLywainlgvAIGPLLGGLLLLYSF-----RLLFLAAAVLFLLAALVLLFLLPETRPKRR------AAE 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 196 EKKKKGGLRTIVGSIVIWHISFVYLFTMEMRTICETWVQLFLTDSK-ISPDAFQITYEIGGLVGTMASGIVIDLATRKfd 274
Cdd:cd17329 186 KTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILgLGESLLGLLLALNALLIVLLQFPVARLVERF-- 263
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 1831518188 275 vdATRRVIAVSYTCLmmfsAAGIFEFAELSSIFGFLAGMFV 315
Cdd:cd17329 264 --RLRKILMIGILLF----AIGFAVLAFANTLAVLILAMIV 298
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
39-122 |
8.80e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 38.31 E-value: 8.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518188 39 LTSDDIGILVSSHALLYTIGRLLFGMASDRYSKVALLLLGLVTCAACSVGLAFSNH---LWQMLIAMMLLGIVQGAGWVP 115
Cdd:cd17321 201 YSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGAdssVWLLLPGLVLLGLGLGLFATP 280
|
....*..
gi 1831518188 116 ATLLVQS 122
Cdd:cd17321 281 LTNAALS 287
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
49-120 |
9.21e-03 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 38.10 E-value: 9.21e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1831518188 49 SSHALLYTIGRLLFGMASDRYSKVALLLLGLVTCAACSVGLAFSNHLWQMLIAMMLLGIVQGAGWVPATLLV 120
Cdd:cd17379 40 SSLNLGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFGKGGWMTGYVLV 111
|
|
| |
