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Conserved domains on  [gi|1831509133|ref|NP_001366633|]
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Apple domain-containing protein [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LGT super family cl00478
Prolipoprotein diacylglyceryl transferase;
1794-1931 2.51e-04

Prolipoprotein diacylglyceryl transferase;


The actual alignment was detected with superfamily member PRK13108:

Pssm-ID: 469786 [Multi-domain]  Cd Length: 460  Bit Score: 46.51  E-value: 2.51e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831509133 1794 EETTTSAVTEASSEATTTPA--GTEASGEETTTSAVTEGSGEETTVVAVVESSGEEPASSSTSIPTELSKNDQVTEASGE 1871
Cdd:PRK13108   299 EPAELAAAAVASAASAVGPVgpGEPNQPDDVAEAVKAEVAEVTDEVAAESVVQVADRDGESTPAVEETSEADIEREQPGD 378

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1831509133 1872 ETITAAATEASEETTTSAvTEGSGEDTtvvAVVELSGEQPASSSTSIP-TELSKDDQVTEA 1931
Cdd:PRK13108   379 LAGQAPAAHQVDAEAASA-APEEPAAL---ASEAHDETEPEVPEKAAPiPDPAKPDELAVA 435
PAN_APPLE super family cl00112
PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth ...
 3181-3220 5.86e-03

PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech anti-platelet proteins. Common structural features include two disulfide bonds that link the alpha-helix to the central region of the protein. PAN domains have significant functional versatility, fulfilling diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.


The actual alignment was detected with superfamily member pfam14295:

Pssm-ID: 469620  Cd Length: 51  Bit Score: 37.38  E-value: 5.86e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1831509133 3181 DVPASSPADCARKCFEMKNCKTAGFIPsPSGTIAQGVCLL 3220
Cdd:pfam14295   12 ELLVDSPEACCAACDADPRCNAWTFVK-PGYQGSYARCWL 50
PAN_1 pfam00024
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some ...
 587-638 9.48e-03

PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.


:

Pssm-ID: 459635  Cd Length: 76  Bit Score: 37.53  E-value: 9.48e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1831509133  587 KELSAKFETEIKVDSVEMCATRCYQD-GCSGARFDPVWSTCSLSYDEKHFCAR 638
Cdd:pfam00024    9 SSLSGVDVSTVTVSSAEECAQRCTNEpRCRSFTYNPKSKKCHLKSSSSGSLPR 61
 
Name Accession Description Interval E-value
PRK13108 PRK13108
prolipoprotein diacylglyceryl transferase; Reviewed
 1794-1931 2.51e-04

prolipoprotein diacylglyceryl transferase; Reviewed


Pssm-ID: 237284 [Multi-domain]  Cd Length: 460  Bit Score: 46.51  E-value: 2.51e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831509133 1794 EETTTSAVTEASSEATTTPA--GTEASGEETTTSAVTEGSGEETTVVAVVESSGEEPASSSTSIPTELSKNDQVTEASGE 1871
Cdd:PRK13108   299 EPAELAAAAVASAASAVGPVgpGEPNQPDDVAEAVKAEVAEVTDEVAAESVVQVADRDGESTPAVEETSEADIEREQPGD 378

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1831509133 1872 ETITAAATEASEETTTSAvTEGSGEDTtvvAVVELSGEQPASSSTSIP-TELSKDDQVTEA 1931
Cdd:PRK13108   379 LAGQAPAAHQVDAEAASA-APEEPAAL---ASEAHDETEPEVPEKAAPiPDPAKPDELAVA 435
PAN_4 pfam14295
PAN domain;
3181-3220 5.86e-03

PAN domain;


Pssm-ID: 433846  Cd Length: 51  Bit Score: 37.38  E-value: 5.86e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1831509133 3181 DVPASSPADCARKCFEMKNCKTAGFIPsPSGTIAQGVCLL 3220
Cdd:pfam14295   12 ELLVDSPEACCAACDADPRCNAWTFVK-PGYQGSYARCWL 50
PAN_1 pfam00024
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some ...
 587-638 9.48e-03

PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.


Pssm-ID: 459635  Cd Length: 76  Bit Score: 37.53  E-value: 9.48e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1831509133  587 KELSAKFETEIKVDSVEMCATRCYQD-GCSGARFDPVWSTCSLSYDEKHFCAR 638
Cdd:pfam00024    9 SSLSGVDVSTVTVSSAEECAQRCTNEpRCRSFTYNPKSKKCHLKSSSSGSLPR 61
 
Name Accession Description Interval E-value
PRK13108 PRK13108
prolipoprotein diacylglyceryl transferase; Reviewed
 1794-1931 2.51e-04

prolipoprotein diacylglyceryl transferase; Reviewed


Pssm-ID: 237284 [Multi-domain]  Cd Length: 460  Bit Score: 46.51  E-value: 2.51e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831509133 1794 EETTTSAVTEASSEATTTPA--GTEASGEETTTSAVTEGSGEETTVVAVVESSGEEPASSSTSIPTELSKNDQVTEASGE 1871
Cdd:PRK13108   299 EPAELAAAAVASAASAVGPVgpGEPNQPDDVAEAVKAEVAEVTDEVAAESVVQVADRDGESTPAVEETSEADIEREQPGD 378

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1831509133 1872 ETITAAATEASEETTTSAvTEGSGEDTtvvAVVELSGEQPASSSTSIP-TELSKDDQVTEA 1931
Cdd:PRK13108   379 LAGQAPAAHQVDAEAASA-APEEPAAL---ASEAHDETEPEVPEKAAPiPDPAKPDELAVA 435
rne PRK10811
ribonuclease E; Reviewed
 1794-1932 1.02e-03

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 45.03  E-value: 1.02e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831509133 1794 EETTTSAVTEASSEATTTPAGTEASGEETTTSAVTEGSGEETTVVAVVESSGEEPASSSTSIPTELSKNDQVTEASGEET 1873
Cdd:PRK10811   863 EVQVQPVVAEVPVAAAVEPVVSAPVVEAVAEVVEEPVVVAEPQPEEVVVVETTHPEVIAAPVTEQPQVITESDVAVAQEV 942

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1831509133 1874 ITAAATEASEETTTSAVTEgSGEDTTVVAVVELSGEQPASSSTSIPTELSKDDQVTEAS 1932
Cdd:PRK10811   943 AEHAEPVVEPQDETADIEE-AAETAEVVVAEPEVVAQPAAPVVAEVAAEVETVTAVEPE 1000
PAN_4 pfam14295
PAN domain;
3181-3220 5.86e-03

PAN domain;


Pssm-ID: 433846  Cd Length: 51  Bit Score: 37.38  E-value: 5.86e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1831509133 3181 DVPASSPADCARKCFEMKNCKTAGFIPsPSGTIAQGVCLL 3220
Cdd:pfam14295   12 ELLVDSPEACCAACDADPRCNAWTFVK-PGYQGSYARCWL 50
PAN_1 pfam00024
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some ...
 587-638 9.48e-03

PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.


Pssm-ID: 459635  Cd Length: 76  Bit Score: 37.53  E-value: 9.48e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1831509133  587 KELSAKFETEIKVDSVEMCATRCYQD-GCSGARFDPVWSTCSLSYDEKHFCAR 638
Cdd:pfam00024    9 SSLSGVDVSTVTVSSAEECAQRCTNEpRCRSFTYNPKSKKCHLKSSSSGSLPR 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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