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Conserved domains on  [gi|1829778907|ref|NP_001366559|]
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leucine-rich repeat-containing protein 39 isoform 4 [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
85-269 9.85e-45

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 157.79  E-value: 9.85e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778907  85 LKIPEFIGRFQHLIVLDLSRNTISEIPRGIGLLTRLQELILSYNKIKTVPKELSNCTSLEKLELAVNRdISDLPPELSKL 164
Cdd:COG4886   103 LSGNEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQ-LTDLPEELGNL 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778907 165 LKLTHLDLSMNQFTTIPHAVLDMPALEWLDMGSNSLQQLPDSLDRMRSLHTLWLQRNEITCLPEtIKNMKNLGTLVLSNN 244
Cdd:COG4886   182 TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNN 260

                         170       180
                  ....*....|....*....|....*
gi 1829778907 245 KLQDIPGCMeEMTNLRFVNFRDNPL 269
Cdd:COG4886   261 QLTDLPPLA-NLTNLKTLDLSNNQL 284
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
85-269 9.85e-45

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 157.79  E-value: 9.85e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778907  85 LKIPEFIGRFQHLIVLDLSRNTISEIPRGIGLLTRLQELILSYNKIKTVPKELSNCTSLEKLELAVNRdISDLPPELSKL 164
Cdd:COG4886   103 LSGNEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQ-LTDLPEELGNL 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778907 165 LKLTHLDLSMNQFTTIPHAVLDMPALEWLDMGSNSLQQLPDSLDRMRSLHTLWLQRNEITCLPEtIKNMKNLGTLVLSNN 244
Cdd:COG4886   182 TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNN 260

                         170       180
                  ....*....|....*....|....*
gi 1829778907 245 KLQDIPGCMeEMTNLRFVNFRDNPL 269
Cdd:COG4886   261 QLTDLPPLA-NLTNLKTLDLSNNQL 284
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 74-279 1.15e-21

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 95.69  E-value: 1.15e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778907  74 LQEWQLHRTGllKIPEFIGRFQHLIVLDLSRNTIS-EIPRGIGLLTRLQELILSYNKIKT-VPKELSNCTSLEKLELAVN 151
Cdd:PLN00113  337 LQLWSNKFSG--EIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLEGeIPKSLGACRSLRRVRLQDN 414

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778907 152 RDISDLPPELSKLLKLTHLDLSMNQFT-TIPHAVLDMPALEWLDMGSNS-LQQLPDSLdRMRSLHTLWLQRNEIT-CLPE 228
Cdd:PLN00113  415 SFSGELPSEFTKLPLVYFLDISNNNLQgRINSRKWDMPSLQMLSLARNKfFGGLPDSF-GSKRLENLDLSRNQFSgAVPR 493

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1829778907 229 TIKNMKNLGTLVLSNNKLQ-DIPGCMEEMTNLRFVNFRDNPLRLEVTLPPSD 279
Cdd:PLN00113  494 KLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSGQIPASFSE 545
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 79-269 1.31e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 60.18  E-value: 1.31e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778907  79 LHRTGLLKIPEFIgRFQHLIVLDLSRNTISEIPrGIGLLTRLQELILSYNKIKTVPkELSNCTSLEKLELAVNRdISDLp 158
Cdd:cd21340     9 LNDKNITKIDNLS-LCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNR-ISVV- 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778907 159 pE-LSKLLKLTHLDLSmNQfttiphavlDMPALEWLDMGSNSLQQLpdsldrMRSLHTLWLQRNEITCLpETIKNMKNLG 237
Cdd:cd21340    84 -EgLENLTNLEELHIE-NQ---------RLPPGEKLTFDPRSLAAL------SNSLRVLNISGNNIDSL-EPLAPLRNLE 145

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1829778907 238 TLVLSNNKLQDIP---GCMEEMTNLRFVNFRDNPL 269
Cdd:cd21340   146 QLDASNNQISDLEellDLLSSWPSLRELDLTGNPV 180
LRR_8 pfam13855
Leucine rich repeat;
141-200 9.88e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 9.88e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1829778907 141 TSLEKLELAVNRdISDLPPE-LSKLLKLTHLDLSMNQFTTI-PHAVLDMPALEWLDMGSNSL 200
Cdd:pfam13855   1 PNLRSLDLSNNR-LTSLDDGaFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
85-269 9.85e-45

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 157.79  E-value: 9.85e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778907  85 LKIPEFIGRFQHLIVLDLSRNTISEIPRGIGLLTRLQELILSYNKIKTVPKELSNCTSLEKLELAVNRdISDLPPELSKL 164
Cdd:COG4886   103 LSGNEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQ-LTDLPEELGNL 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778907 165 LKLTHLDLSMNQFTTIPHAVLDMPALEWLDMGSNSLQQLPDSLDRMRSLHTLWLQRNEITCLPEtIKNMKNLGTLVLSNN 244
Cdd:COG4886   182 TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNN 260

                         170       180
                  ....*....|....*....|....*
gi 1829778907 245 KLQDIPGCMeEMTNLRFVNFRDNPL 269
Cdd:COG4886   261 QLTDLPPLA-NLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
39-270 1.49e-32

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 125.05  E-value: 1.49e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778907  39 LVRIWEDRVSLTKLKEKVTREDGRVILRIEKEEWKLQEWQLHRTGLLKIPEFIGRFQHLIVLDLSRNTISEIPRGIGLLT 118
Cdd:COG4886    17 LLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLT 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778907 119 RLQELILSYNKiktvpkELSNCTSLEKLELAVNRdISDLPPELSKLLKLTHLDLSMNQFTTIPHAVLDMPALEWLDMGSN 198
Cdd:COG4886    97 NLTELDLSGNE------ELSNLTNLESLDLSGNQ-LTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNN 169

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1829778907 199 SLQQLPDSLDRMRSLHTLWLQRNEITCLPETIKNMKNLGTLVLSNNKLQDIPGCMEEMTNLRFVNFRDNPLR 270
Cdd:COG4886   170 QLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLT 241
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 74-279 1.15e-21

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 95.69  E-value: 1.15e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778907  74 LQEWQLHRTGllKIPEFIGRFQHLIVLDLSRNTIS-EIPRGIGLLTRLQELILSYNKIKT-VPKELSNCTSLEKLELAVN 151
Cdd:PLN00113  337 LQLWSNKFSG--EIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLEGeIPKSLGACRSLRRVRLQDN 414

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778907 152 RDISDLPPELSKLLKLTHLDLSMNQFT-TIPHAVLDMPALEWLDMGSNS-LQQLPDSLdRMRSLHTLWLQRNEIT-CLPE 228
Cdd:PLN00113  415 SFSGELPSEFTKLPLVYFLDISNNNLQgRINSRKWDMPSLQMLSLARNKfFGGLPDSF-GSKRLENLDLSRNQFSgAVPR 493

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1829778907 229 TIKNMKNLGTLVLSNNKLQ-DIPGCMEEMTNLRFVNFRDNPLRLEVTLPPSD 279
Cdd:PLN00113  494 KLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSGQIPASFSE 545
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
73-282 1.03e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.14  E-value: 1.03e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778907  73 KLQEWQLHRTGLLKIPEFIGRFQHLIVLDLSRNTISEIPRGIGLLTRLQELILSYNKIKTVPKELSNCTSLEKLELAVNR 152
Cdd:COG4886   160 NLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQ 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778907 153 dISDLP---------------------PELSKLLKLTHLDLSMNQFTTIPHAVLDMPALEWLDMGSNSLQQLPDSLDRMR 211
Cdd:COG4886   240 -LTDLPelgnltnleeldlsnnqltdlPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLL 318

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1829778907 212 SLHTLWLQRNEITCLPETIKNMKNLGTLVLSNNKLQDIPGCMEEMTNLRFVNFRDNPLRLEVTLPPSDNTD 282
Cdd:COG4886   319 LLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTL 389
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 86-273 1.41e-17

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 83.74  E-value: 1.41e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778907  86 KIPEFIGRFQHLIVLDLSRNTIS-EIPRGIGLLTRLQELILSYNK-IKTVPKELSNCTSLEKLELAVNRDISDLPPELSK 163
Cdd:PLN00113  155 EIPNDIGSFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQlVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGG 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778907 164 LLKLTHLDLSMNQFT-TIPHAVLDMPALEWLDMGSNSLQ-QLPDSLDRMRSLHTLWLQRNEITC-LPETIKNMKNLGTLV 240
Cdd:PLN00113  235 LTSLNHLDLVYNNLTgPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSGeIPELVIQLQNLEILH 314

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1829778907 241 L-SNNKLQDIPGCMEEMTNLRFVNFRDNPLRLEV 273
Cdd:PLN00113  315 LfSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEI 348
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 86-269 1.72e-16

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 80.28  E-value: 1.72e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778907  86 KIPEFIGRFQHLIVLDLSRNT-ISEIPRGIGLLTRLQELILSYNKIK-TVPKELSNCTSLEKLELAVNRDISDLPPELSK 163
Cdd:PLN00113  179 KIPNSLTNLTSLEFLTLASNQlVGQIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGN 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778907 164 LLKLTHLDLSMNQFT-TIPHAVLDMPALEWLDMGSNSLQ-QLPDSLDRMRSLHTLWLQRNEITC-LPETIKNMKNLGTLV 240
Cdd:PLN00113  259 LKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTGkIPVALTSLPRLQVLQ 338

                         170       180       190
                  ....*....|....*....|....*....|
gi 1829778907 241 LSNNKLQ-DIPGCMEEMTNLRFVNFRDNPL 269
Cdd:PLN00113  339 LWSNKFSgEIPKNLGKHNNLTVLDLSTNNL 368
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 97-273 3.21e-16

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 79.51  E-value: 3.21e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778907  97 LIVLDLSRNTIS-EIPRGigLLTRLQELILSYNKIK-TVPKELSNCTSLEKLELAVNRDISDLPPELSKLLKLTHLDLSM 174
Cdd:PLN00113  120 LRYLNLSNNNFTgSIPRG--SIPNLETLDLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLAS 197

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778907 175 NQFT-TIPHAVLDMPALEWLDMGSNSLQ-QLPDSLDRMRSLHTLWLQRNEITC-LPETIKNMKNLGTLVLSNNKLQD-IP 250
Cdd:PLN00113  198 NQLVgQIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDLVYNNLTGpIPSSLGNLKNLQYLFLYQNKLSGpIP 277

                         170       180
                  ....*....|....*....|...
gi 1829778907 251 GCMEEMTNLRFVNFRDNPLRLEV 273
Cdd:PLN00113  278 PSIFSLQKLISLDLSDNSLSGEI 300
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 66-213 3.94e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 67.18  E-value: 3.94e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778907  66 RIEKEEW---KLQEWQLHRTGLL-KIPEFIGRfQHLIVLDLSRNTISE-IPRGIGLLTRLQELILSYNKIK-TVPKELSN 139
Cdd:PLN00113  443 RINSRKWdmpSLQMLSLARNKFFgGLPDSFGS-KRLENLDLSRNQFSGaVPRKLGSLSELMQLKLSENKLSgEIPDELSS 521

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1829778907 140 CTsleklelavnrdisdlppelskllKLTHLDLSMNQFT-TIPHAVLDMPALEWLDMGSNSLQ-QLPDSLDRMRSL 213
Cdd:PLN00113  522 CK------------------------KLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESL 573
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 79-269 1.31e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 60.18  E-value: 1.31e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778907  79 LHRTGLLKIPEFIgRFQHLIVLDLSRNTISEIPrGIGLLTRLQELILSYNKIKTVPkELSNCTSLEKLELAVNRdISDLp 158
Cdd:cd21340     9 LNDKNITKIDNLS-LCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNR-ISVV- 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778907 159 pE-LSKLLKLTHLDLSmNQfttiphavlDMPALEWLDMGSNSLQQLpdsldrMRSLHTLWLQRNEITCLpETIKNMKNLG 237
Cdd:cd21340    84 -EgLENLTNLEELHIE-NQ---------RLPPGEKLTFDPRSLAAL------SNSLRVLNISGNNIDSL-EPLAPLRNLE 145

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1829778907 238 TLVLSNNKLQDIP---GCMEEMTNLRFVNFRDNPL 269
Cdd:cd21340   146 QLDASNNQISDLEellDLLSSWPSLRELDLTGNPV 180
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 89-239 2.34e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 56.72  E-value: 2.34e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778907  89 EFIGRFQHLIVLDLSRNTISEIPrGIGLLTRLQELILSYNKIKTVpKELSNCTSLEKLELAVNRdisdLPPE-------- 160
Cdd:cd21340    40 ENLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNRISVV-EGLENLTNLEELHIENQR----LPPGekltfdpr 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778907 161 -LSKLLK-LTHLDLSMNQFTTI-PHAVLDmpALEWLDMGSN---SLQQLPDSLDRMRSLHTLWLQRNEITCLP----ETI 230
Cdd:cd21340   114 sLAALSNsLRVLNISGNNIDSLePLAPLR--NLEQLDASNNqisDLEELLDLLSSWPSLRELDLTGNPVCKKPkyrdKII 191


                  ....*....
gi 1829778907 231 KNMKNLGTL 239
Cdd:cd21340   192 LASKSLEVL 200
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
3-236 3.87e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 54.70  E-value: 3.87e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778907   3 ESAVCTGAVSAVKE--VWEERIKKH--HEDVKREKEFQ-------HKLVRIWEDRVSLTKLKEKVTREDGRVILriEKEE 71
Cdd:PRK15370  133 QASSASGSKDAVNYelIWSEWVKEApaKEAANREEAVQrmrdclkNNKTELRLKILGLTTIPACIPEQITTLIL--DNNE 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778907  72 WK---------LQEWQLHRTGLLKIPEFIGrfQHLIVLDLSRNTISEIPRGigLLTRLQELILSYNKIKTVPKEL----- 137
Cdd:PRK15370  211 LKslpenlqgnIKTLYANSNQLTSIPATLP--DTIQEMELSINRITELPER--LPSALQSLDLFHNKISCLPENLpeelr 286

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778907 138 ------SNCTSLEK------LELAV-NRDISDLPPELSKLLK-------------------LTHLDLSMNQFTTIP---- 181
Cdd:PRK15370  287 ylsvydNSIRTLPAhlpsgiTHLNVqSNSLTALPETLPPGLKtleagenaltslpaslppeLQVLDVSKNQITVLPetlp 366

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1829778907 182 ----------HAVLDMP-----ALEWLDMGSNSLQQLPDSLDRMRS----LHTLWLQRNEITclPETIKNMKNL 236
Cdd:PRK15370  367 ptittldvsrNALTNLPenlpaALQIMQASRNNLVRLPESLPHFRGegpqPTRIIVEYNPFS--ERTIQNMQRL 438
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
42-278 9.76e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 53.55  E-value: 9.76e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778907  42 IWEDRVSLTKLKEKVTREDGRVILR--IEKEEWKLQewqLHRTGLLKIPEFIgrfqhlivldlsrntiseiPRGIglltr 119
Cdd:PRK15370  149 IWSEWVKEAPAKEAANREEAVQRMRdcLKNNKTELR---LKILGLTTIPACI-------------------PEQI----- 201

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778907 120 lQELILSYNKIKTVPKELSNCTSleklELAVNRdisdlppelskllklthldlsmNQFTTIPHAVLDmpALEWLDMGSNS 199
Cdd:PRK15370  202 -TTLILDNNELKSLPENLQGNIK----TLYANS----------------------NQLTSIPATLPD--TIQEMELSINR 252

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778907 200 LQQLPDSLDRmrSLHTLWLQRNEITCLPETIKNmkNLGTLVLSNNKLQDIPGCMEemTNLRFVNFRDNPLR-LEVTLPPS 278
Cdd:PRK15370  253 ITELPERLPS--ALQSLDLFHNKISCLPENLPE--ELRYLSVYDNSIRTLPAHLP--SGITHLNVQSNSLTaLPETLPPG 326
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 119-246 1.09e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 52.74  E-value: 1.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778907 119 RLQELILSYNKI-----KTVPKELSNCTSLEKLELAVNrDISD-----LPPELSKLLKLTHLDLSMNQFT-----TIPHA 183
Cdd:cd00116   138 ALEKLVLGRNRLegascEALAKALRANRDLKELNLANN-GIGDagiraLAEGLKANCNLEVLDLNNNGLTdegasALAET 216

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1829778907 184 VLDMPALEWLDMGSNSLQQ------LPDSLDRMRSLHTLWLQRNEITC-----LPETIKNMKNLGTLVLSNNKL 246
Cdd:cd00116   217 LASLKSLEVLNLGDNNLTDagaaalASALLSPNISLLTLSLSCNDITDdgakdLAEVLAEKESLLELDLRGNKF 290
PLN03150 PLN03150
hypothetical protein; Provisional
 87-165 1.89e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 52.51  E-value: 1.89e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778907  87 IPEFIGRFQHLIVLDLSRNTI-SEIPRGIGLLTRLQELILSYNKIK-TVPKELSNCTSLEKLELAVNRDISDLPPELSKL 164
Cdd:PLN03150  434 IPNDISKLRHLQSINLSGNSIrGNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSGRVPAALGGR 513


                  .
gi 1829778907 165 L 165
Cdd:PLN03150  514 L 514
LRR_8 pfam13855
Leucine rich repeat;
141-200 9.88e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 9.88e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1829778907 141 TSLEKLELAVNRdISDLPPE-LSKLLKLTHLDLSMNQFTTI-PHAVLDMPALEWLDMGSNSL 200
Cdd:pfam13855   1 PNLRSLDLSNNR-LTSLDDGaFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
211-269 1.19e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 1.19e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1829778907 211 RSLHTLWLQRNEITCL-PETIKNMKNLGTLVLSNNKLQDI-PGCMEEMTNLRFVNFRDNPL 269
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 65-272 3.34e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.04  E-value: 3.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778907  65 LRIEKEEWKLQEWQlhrtgllkipEFIGRFQHLIVLDLSRNTISEIpRGIGLLTRLQ------ELILSYNK-------IK 131
Cdd:cd00116     3 LSLKGELLKTERAT----------ELLPKLLCLQVLRLEGNTLGEE-AAKALASALRpqpslkELCLSLNEtgriprgLQ 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778907 132 TVPKELSNCTSLEKLELAVNRDISDLPPELSKLLK---LTHLDLSMNQF-----TTIPHAVLD-MPALEWLDMGSNSL-- 200
Cdd:cd00116    72 SLLQGLTKGCGLQELDLSDNALGPDGCGVLESLLRsssLQELKLNNNGLgdrglRLLAKGLKDlPPALEKLVLGRNRLeg 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778907 201 ---QQLPDSLDRMRSLHTLWLQRNE-----ITCLPETIKNMKNLGTLVLSNNKL-----QDIPGCMEEMTNLRFVNFRDN 267
Cdd:cd00116   152 ascEALAKALRANRDLKELNLANNGigdagIRALAEGLKANCNLEVLDLNNNGLtdegaSALAETLASLKSLEVLNLGDN 231


                  ....*
gi 1829778907 268 PLRLE 272
Cdd:cd00116   232 NLTDA 236
LRR_8 pfam13855
Leucine rich repeat;
166-223 3.95e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.97  E-value: 3.95e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778907 166 KLTHLDLSMNQFTTI-PHAVLDMPALEWLDMGSNSLQQL-PDSLDRMRSLHTLWLQRNEI 223
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
73-130 4.40e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.59  E-value: 4.40e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778907  73 KLQEWQLHRTGLLKI-PEFIGRFQHLIVLDLSRNTISEI-PRGIGLLTRLQELILSYNKI 130
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
95-152 8.84e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.82  E-value: 8.84e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778907  95 QHLIVLDLSRNTISEIPRGIGL-LTRLQELILSYNKIKTV-PKELSNCTSLEKLELAVNR 152
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNR 60
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 118-159 1.87e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.38  E-value: 1.87e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1829778907 118 TRLQELILSYNKIKTVPkELSNCTSLEKLELAVNRDISDLPP 159
Cdd:pfam12799   1 PNLEVLDLSNNQITDIP-PLAKLPNLETLDLSGNNKITDLSD 41
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 164-260 3.45e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.31  E-value: 3.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778907 164 LLKLTHLDLSMNQFTTIPhaVLDM-PALEWLDMGSNSLQQLPDsLDRMRSLHTLWLQRNEITCLpETIKNMKNLGTLVLS 242
Cdd:cd21340     1 LKRITHLYLNDKNITKID--NLSLcKNLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLG 76

                          90
                  ....*....|....*...
gi 1829778907 243 NNKLQDIPGcMEEMTNLR 260
Cdd:cd21340    77 GNRISVVEG-LENLTNLE 93
PLN03150 PLN03150
hypothetical protein; Provisional
 110-184 3.88e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.11  E-value: 3.88e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1829778907 110 IPRGIGLLTRLQELILSYNKIK-TVPKELSNCTSLEKLELAVNRDISDLPPELSKLLKLTHLDLSMNQFT-TIPHAV 184
Cdd:PLN03150  434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSgRVPAAL 510
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 100-266 5.35e-04

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 41.78  E-value: 5.35e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778907  100 LDLSRNTISEIPRGIGLlTRLQELILSYNKIKTVPKELSNCT--------SLEKLELAVNRDISDLPPELSKLLKLTHLD 171
Cdd:PLN03210   730 LDLDETAIEEFPSNLRL-ENLDELILCEMKSEKLWERVQPLTplmtmlspSLTRLFLSDIPSLVELPSSIQNLHKLEHLE 808

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778907  172 LsMN--QFTTIPHAVlDMPALEWLDM-GSNSLQQLPDSldrMRSLHTLWLQRNEITCLPETIKNMKNLGTLVLSN-NKLQ 247
Cdd:PLN03210   809 I-ENciNLETLPTGI-NLESLESLDLsGCSRLRTFPDI---STNISDLNLSRTGIEEVPWWIEKFSNLSFLDMNGcNNLQ 883

                          170
                   ....*....|....*....
gi 1829778907  248 DIPGCMEEMTNLRFVNFRD 266
Cdd:PLN03210   884 RVSLNISKLKHLETVDFSD 902
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 49-248 7.52e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 40.93  E-value: 7.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778907  49 LTKLKEKVTREDGRVILRIEKEEWKLQEWQLHrtgllkIPEFIGRFQHLIVLDLSRNTISEiprgiglltrlqelilsyN 128
Cdd:COG5238   140 RINLIQVLKDPLGGNAVHLLGLAARLGLLAAI------SMAKALQNNSVETVYLGCNQIGD------------------E 195

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778907 129 KIKTVPKELSNCTSLEKLELAVNrDISDLPPE-----LSKLLKLTHLDLSMNQfttiphavldmpalewldMGSNSLQQL 203
Cdd:COG5238   196 GIEELAEALTQNTTVTTLWLKRN-PIGDEGAEilaeaLKGNKSLTTLDLSNNQ------------------IGDEGVIAL 256

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1829778907 204 PDSLDRMRSLHTLWLQRNEITC-----LPETIKNMKNLGTLVLSNNKLQD 248
Cdd:COG5238   257 AEALKNNTTVETLYLSGNQIGAegaiaLAKALQGNTTLTSLDLSVNRIGD 306
PLN03150 PLN03150
hypothetical protein; Provisional
 157-224 8.64e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.95  E-value: 8.64e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778907 157 LPPELSKLLKLTHLDLSMNQFT-TIPHAVLDMPALEWLDMGSNSLQ-QLPDSLDRMRSLHTLWLQRNEIT 224
Cdd:PLN03150  434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLS 503
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
74-248 9.12e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 40.92  E-value: 9.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778907  74 LQEWQLHRTGLLKIPEFIGRFQHLIVLDLSRNTISEIPRGiglltrLQELILSYNKIKTVPKELSNCTSLekleLAVNRD 153
Cdd:PRK15387  304 LQELSVSDNQLASLPALPSELCKLWAYNNQLTSLPTLPSG------LQELSVSDNQLASLPTLPSELYKL----WAYNNR 373

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778907 154 ISDLPPELSKLLKLThldLSMNQFTTIPHavldMPA-LEWLDMGSNSLQQLPDSLDRMRSLHtlwLQRNEITCLPETIKN 232
Cdd:PRK15387  374 LTSLPALPSGLKELI---VSGNRLTSLPV----LPSeLKELMVSGNRLTSLPMLPSGLLSLS---VYRNQLTRLPESLIH 443

                         170
                  ....*....|....*.
gi 1829778907 233 MKNLGTLVLSNNKLQD 248
Cdd:PRK15387  444 LSSETTVNLEGNPLSE 459
PLN03150 PLN03150
hypothetical protein; Provisional
 202-273 1.15e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.57  E-value: 1.15e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1829778907 202 QLPDSLDRMRSLHTLWLQRNEIT-CLPETIKNMKNLGTLVLSNNKLQ-DIPGCMEEMTNLRFVNFRDNPLRLEV 273
Cdd:PLN03150  433 FIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSGRV 506
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 190-260 4.60e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 38.62  E-value: 4.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778907 190 LEWLDMGSNSLQQ-----LPDSLDRMRSLHTLWLQRNEIT-----CLPETIKNMKNLGTLVLSNNKLQDiPGCMEEMTNL 259
Cdd:COG5238   182 VETVYLGCNQIGDegieeLAEALTQNTTVTTLWLKRNPIGdegaeILAEALKGNKSLTTLDLSNNQIGD-EGVIALAEAL 260


                  .
gi 1829778907 260 R 260
Cdd:COG5238   261 K 261
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
83-269 4.64e-03

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 38.60  E-value: 4.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778907  83 GLLKIPEFIGRFQHLIVLD-------LSRNTISEIPRgigLLTRLQELILSYNKIKTVPKELSNCTSLekleLAVNRDIS 155
Cdd:PRK15387  263 GLLELSIFSNPLTHLPALPsglcklwIFGNQLTSLPV---LPPGLQELSVSDNQLASLPALPSELCKL----WAYNNQLT 335

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778907 156 DLPPELSKLLKLTHLDLSMNQFTTIPHAVLDMPA----LEWLDMGSNSLQQLPDSLDRMRSL-------HTLWLQRNEIT 224
Cdd:PRK15387  336 SLPTLPSGLQELSVSDNQLASLPTLPSELYKLWAynnrLTSLPALPSGLKELIVSGNRLTSLpvlpselKELMVSGNRLT 415

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1829778907 225 CLPetiknMKNLGTLVLS--NNKLQDIPGCMEEMTNLRFVNFRDNPL 269
Cdd:PRK15387  416 SLP-----MLPSGLLSLSvyRNQLTRLPESLIHLSSETTVNLEGNPL 457
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 100-224 7.14e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 37.85  E-value: 7.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778907 100 LDLSRNTISE-----IPRGIGLLTRLQELILSYNKI-----KTVPKELSNCTSLEKLELAVNRdISD-----LPPELSKL 164
Cdd:COG5238   269 LYLSGNQIGAegaiaLAKALQGNTTLTSLDLSVNRIgdegaIALAEGLQGNKTLHTLNLAYNG-IGAqgaiaLAKALQEN 347

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829778907 165 LKLTHLDLSMNQFT-----TIPHAVLDMPALEWLDMGSNSL-----QQLPDSLDRMRsLHTLWLQRNEIT 224
Cdd:COG5238   348 TTLHSLDLSDNQIGdegaiALAKYLEGNTTLRELNLGKNNIgkqgaEALIDALQTNR-LHTLILDGNLIG 416
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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