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Conserved domains on  [gi|1829661190|ref|NP_001366543|]
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proton-associated sugar transporter A isoform 1 [Homo sapiens]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 87-730 2.13e-76

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17313:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 421  Bit Score: 252.93  E-value: 2.13e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829661190  87 LLFNGCILFGIEFSYAMETAYVTPVLLQMGLPDQLYSLVWFISPILGFLLQPLLGAWSDRCTSRFGRRRPFILVlaigal 166
Cdd:cd17313     1 LFLLGFGFFGIEFGWALENSYVPPILQTLGLSHALIGFVWTLGPILGLFVQPLVGSLSDRCNSRIGRRRPFILV------ 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829661190 167 lglslllngrdigialadvtgnhkwGLLLTVCGVVLMDFSADsadnpshaymmdvcspadqdrglnihallaglgggfgy 246
Cdd:cd17313    75 -------------------------GAPLAALGLILIPNAAD-------------------------------------- 91

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829661190 247 vvggihwdktgFGRALGGQLRVIYLFTAVtlsVTTVLTLVS--IPERPLR-------PPSEKRAAMkspslplppsppvl 317
Cdd:cd17313    92 -----------IGLALGDGPRTWALVLFV---LGIVLLDFAmnVCQGPVRallpdlvPPEQRSKAN-------------- 143

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829661190 318 peegpgdslpshtatnfsspisppspltpkygSFISRDSSLTGIseFASSFGTANIDSVLIDCFTGGHDSYLAIPGSVpr 397
Cdd:cd17313   144 --------------------------------GIINFMGGLGGV--LGYLLGAILWDHNWFGFALGGNLKVPFYIGAI-- 187

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829661190 398 ppisvsfprapdgfyrqdrgllegregaltsgcdgdILRVGSLDTskprssgilkrpqTLAIPDaaggggpetsrrrnvt 477
Cdd:cd17313   188 ------------------------------------ILLVCVLVT-------------LFFVKE---------------- 202

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829661190 478 fsqqvanillngVKYESELTGSSERAEQPLSVGRLCSTICNMPKALRTLCVNHFLGelpakpprWLSFEGMLLFYTDFMG 557
Cdd:cd17313   203 ------------PPLSPEAGEHSENPSLGEVLKSLLKLLKIMPRSLLRLLLVIFFW--------WIAFFPFELFFTDYMG 262

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829661190 558 EVVFQGdpkaphTSEAYQKYNSGVTMGCWGMCIYAFSAAFYSAILEKLEEFLSVRTLYFIAYLAFGLGTGLATLSRNLYV 637
Cdd:cd17313   263 EEVYHG------TSAASSHYGAGVRMGAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTV 336

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829661190 638 VLSLCITYGILFSTLCTLPYSLLCDYYQSKkfagssadgtRRGMGVDISLLSCQYFLAQILVSLVLGPL--TSAVGSANG 715
Cdd:cd17313   337 ALVLFALGGIGWATININPYPLVSDYHSES----------GRGQGTDTGLLNLAISLAQILVSLLAGPIidVKGYGTVFP 406

                         650
                  ....*....|....*
gi 1829661190 716 VMYFSSLVSFLGCLY 730
Cdd:cd17313   407 VAAVASFLSLVGALF 421
 
Name Accession Description Interval E-value
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 87-730 2.13e-76

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 252.93  E-value: 2.13e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829661190  87 LLFNGCILFGIEFSYAMETAYVTPVLLQMGLPDQLYSLVWFISPILGFLLQPLLGAWSDRCTSRFGRRRPFILVlaigal 166
Cdd:cd17313     1 LFLLGFGFFGIEFGWALENSYVPPILQTLGLSHALIGFVWTLGPILGLFVQPLVGSLSDRCNSRIGRRRPFILV------ 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829661190 167 lglslllngrdigialadvtgnhkwGLLLTVCGVVLMDFSADsadnpshaymmdvcspadqdrglnihallaglgggfgy 246
Cdd:cd17313    75 -------------------------GAPLAALGLILIPNAAD-------------------------------------- 91

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829661190 247 vvggihwdktgFGRALGGQLRVIYLFTAVtlsVTTVLTLVS--IPERPLR-------PPSEKRAAMkspslplppsppvl 317
Cdd:cd17313    92 -----------IGLALGDGPRTWALVLFV---LGIVLLDFAmnVCQGPVRallpdlvPPEQRSKAN-------------- 143

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829661190 318 peegpgdslpshtatnfsspisppspltpkygSFISRDSSLTGIseFASSFGTANIDSVLIDCFTGGHDSYLAIPGSVpr 397
Cdd:cd17313   144 --------------------------------GIINFMGGLGGV--LGYLLGAILWDHNWFGFALGGNLKVPFYIGAI-- 187

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829661190 398 ppisvsfprapdgfyrqdrgllegregaltsgcdgdILRVGSLDTskprssgilkrpqTLAIPDaaggggpetsrrrnvt 477
Cdd:cd17313   188 ------------------------------------ILLVCVLVT-------------LFFVKE---------------- 202

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829661190 478 fsqqvanillngVKYESELTGSSERAEQPLSVGRLCSTICNMPKALRTLCVNHFLGelpakpprWLSFEGMLLFYTDFMG 557
Cdd:cd17313   203 ------------PPLSPEAGEHSENPSLGEVLKSLLKLLKIMPRSLLRLLLVIFFW--------WIAFFPFELFFTDYMG 262

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829661190 558 EVVFQGdpkaphTSEAYQKYNSGVTMGCWGMCIYAFSAAFYSAILEKLEEFLSVRTLYFIAYLAFGLGTGLATLSRNLYV 637
Cdd:cd17313   263 EEVYHG------TSAASSHYGAGVRMGAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTV 336

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829661190 638 VLSLCITYGILFSTLCTLPYSLLCDYYQSKkfagssadgtRRGMGVDISLLSCQYFLAQILVSLVLGPL--TSAVGSANG 715
Cdd:cd17313   337 ALVLFALGGIGWATININPYPLVSDYHSES----------GRGQGTDTGLLNLAISLAQILVSLLAGPIidVKGYGTVFP 406

                         650
                  ....*....|....*
gi 1829661190 716 VMYFSSLVSFLGCLY 730
Cdd:cd17313   407 VAAVASFLSLVGALF 421
GPH_sucrose TIGR01301
GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in ...
 83-222 1.36e-18

GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in plants, from the Glycoside-Pentoside-Hexuronide (GPH)/cation symporter family. These proteins are predicted to have 12 transmembrane domains. Members may export sucrose (e.g. SUT1, SUT4) from green parts to the phloem for long-distance transport or import sucrose (e.g SUT2) to sucrose sinks such as the tap root of the carrot.


Pssm-ID: 273545 [Multi-domain]  Cd Length: 477  Bit Score: 89.48  E-value: 1.36e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829661190  83 SFRELLFNGCILFGIEFSYAMETAYVTPVLLQMGLPDQLYSLVWFISPILGFLLQPLLGAWSDRCTSRFGRRRPFILVLA 162
Cdd:TIGR01301   2 PLRKLLRVASVAAGVQFGWALQLSLLTPYVQELGIPHAWASIIWLCGPLSGLLVQPLVGYLSDRCTSRFGRRRPFIAAGA 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1829661190 163 IGALLGLSLLLNGRDIGIALAD-VTGNHKWGLLLT-VCGVVLMDFSADSADNPSHAYMMDVC 222
Cdd:TIGR01301  82 ALVAFAVILIGFAADIGHLFGDnLDKKTKPRAIIVfVVGFWILDVANNMLQGPCRAFLADLT 143
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
83-165 4.58e-13

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 71.86  E-value: 4.58e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829661190  83 SFRELLFNGCILFGIEFSYAMETAYVTPVLLQ-MGLPDQLYSLVWFISPILGFLLQPLLGAWSDRCTSRFGRRRPFILVL 161
Cdd:COG2211     8 SLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDvLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWGRRRPWILIG 87


                  ....
gi 1829661190 162 AIGA 165
Cdd:COG2211    88 AIPL 91
MFS_2 pfam13347
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ...
 89-165 4.22e-04

MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.


Pssm-ID: 433134 [Multi-domain]  Cd Length: 427  Bit Score: 43.45  E-value: 4.22e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1829661190  89 FNGCILFGIEFSYAMETAYVTPVLLQ-MGLPDQLYSLVWFISPILGFLLQPLLGAWSDRCTSRFGRRRPFILVLAIGA 165
Cdd:pfam13347   1 GYGSGALAAGIKYAGLATYLLYFYTDvLGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTRTRWGRRRPWLLLSAIIL 78
 
Name Accession Description Interval E-value
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 87-730 2.13e-76

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 252.93  E-value: 2.13e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829661190  87 LLFNGCILFGIEFSYAMETAYVTPVLLQMGLPDQLYSLVWFISPILGFLLQPLLGAWSDRCTSRFGRRRPFILVlaigal 166
Cdd:cd17313     1 LFLLGFGFFGIEFGWALENSYVPPILQTLGLSHALIGFVWTLGPILGLFVQPLVGSLSDRCNSRIGRRRPFILV------ 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829661190 167 lglslllngrdigialadvtgnhkwGLLLTVCGVVLMDFSADsadnpshaymmdvcspadqdrglnihallaglgggfgy 246
Cdd:cd17313    75 -------------------------GAPLAALGLILIPNAAD-------------------------------------- 91

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829661190 247 vvggihwdktgFGRALGGQLRVIYLFTAVtlsVTTVLTLVS--IPERPLR-------PPSEKRAAMkspslplppsppvl 317
Cdd:cd17313    92 -----------IGLALGDGPRTWALVLFV---LGIVLLDFAmnVCQGPVRallpdlvPPEQRSKAN-------------- 143

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829661190 318 peegpgdslpshtatnfsspisppspltpkygSFISRDSSLTGIseFASSFGTANIDSVLIDCFTGGHDSYLAIPGSVpr 397
Cdd:cd17313   144 --------------------------------GIINFMGGLGGV--LGYLLGAILWDHNWFGFALGGNLKVPFYIGAI-- 187

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829661190 398 ppisvsfprapdgfyrqdrgllegregaltsgcdgdILRVGSLDTskprssgilkrpqTLAIPDaaggggpetsrrrnvt 477
Cdd:cd17313   188 ------------------------------------ILLVCVLVT-------------LFFVKE---------------- 202

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829661190 478 fsqqvanillngVKYESELTGSSERAEQPLSVGRLCSTICNMPKALRTLCVNHFLGelpakpprWLSFEGMLLFYTDFMG 557
Cdd:cd17313   203 ------------PPLSPEAGEHSENPSLGEVLKSLLKLLKIMPRSLLRLLLVIFFW--------WIAFFPFELFFTDYMG 262

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829661190 558 EVVFQGdpkaphTSEAYQKYNSGVTMGCWGMCIYAFSAAFYSAILEKLEEFLSVRTLYFIAYLAFGLGTGLATLSRNLYV 637
Cdd:cd17313   263 EEVYHG------TSAASSHYGAGVRMGAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTV 336

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829661190 638 VLSLCITYGILFSTLCTLPYSLLCDYYQSKkfagssadgtRRGMGVDISLLSCQYFLAQILVSLVLGPL--TSAVGSANG 715
Cdd:cd17313   337 ALVLFALGGIGWATININPYPLVSDYHSES----------GRGQGTDTGLLNLAISLAQILVSLLAGPIidVKGYGTVFP 406

                         650
                  ....*....|....*
gi 1829661190 716 VMYFSSLVSFLGCLY 730
Cdd:cd17313   407 VAAVASFLSLVGALF 421
GPH_sucrose TIGR01301
GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in ...
 83-222 1.36e-18

GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in plants, from the Glycoside-Pentoside-Hexuronide (GPH)/cation symporter family. These proteins are predicted to have 12 transmembrane domains. Members may export sucrose (e.g. SUT1, SUT4) from green parts to the phloem for long-distance transport or import sucrose (e.g SUT2) to sucrose sinks such as the tap root of the carrot.


Pssm-ID: 273545 [Multi-domain]  Cd Length: 477  Bit Score: 89.48  E-value: 1.36e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829661190  83 SFRELLFNGCILFGIEFSYAMETAYVTPVLLQMGLPDQLYSLVWFISPILGFLLQPLLGAWSDRCTSRFGRRRPFILVLA 162
Cdd:TIGR01301   2 PLRKLLRVASVAAGVQFGWALQLSLLTPYVQELGIPHAWASIIWLCGPLSGLLVQPLVGYLSDRCTSRFGRRRPFIAAGA 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1829661190 163 IGALLGLSLLLNGRDIGIALAD-VTGNHKWGLLLT-VCGVVLMDFSADSADNPSHAYMMDVC 222
Cdd:TIGR01301  82 ALVAFAVILIGFAADIGHLFGDnLDKKTKPRAIIVfVVGFWILDVANNMLQGPCRAFLADLT 143
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
83-165 4.58e-13

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 71.86  E-value: 4.58e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829661190  83 SFRELLFNGCILFGIEFSYAMETAYVTPVLLQ-MGLPDQLYSLVWFISPILGFLLQPLLGAWSDRCTSRFGRRRPFILVL 161
Cdd:COG2211     8 SLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDvLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWGRRRPWILIG 87


                  ....
gi 1829661190 162 AIGA 165
Cdd:COG2211    88 AIPL 91
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 543-729 1.35e-05

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 47.95  E-value: 1.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829661190 543 LSFEGMLLFYT------DFMGEVvFQGDPKaphtseayqkyNSGVTMGCwgMCIYAFSAAFYSAILEKLeefLSVRTLYF 616
Cdd:cd17473   205 LAFLAMLLFYVipiqlpFLLQER-GGGSAA-----------LIGLALAI--ASLAGAIGALLFGRLKRR---LGKRRLLA 267

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829661190 617 IAYLAFGLGTGLATLSRNLYVVLSLCITYGILFSTLctLPYSLLcdyyqskkFAGSSADGTRRGMGvdISLLSCQYFLAQ 696
Cdd:cd17473   268 IGFALMALGFLLLALASGLWVVLLGAILAGLGFGLL--LPTLNS--------WAMSLVPPELRGRA--MGIVTSAFFLGQ 335

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1829661190 697 ILVSLVLGPLTSAVGSANGVMYFSSLVSFLGCL 729
Cdd:cd17473   336 FLSPLVLGPLVNLTGGLSGAFLILGVLALVLAI 368
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 91-299 2.39e-05

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 47.42  E-value: 2.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829661190  91 GCILFGIEFSYAMETAYVTPVLLQMGLPDQLYSLVWFISPILGFLLQPLLGAWSDrctsRFGRRRPFILVLAIGAllgls 170
Cdd:cd06174     2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLAD----RFGRRPVLLLGLLLFA----- 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829661190 171 lllngrdIGIALAdvTGNHKWGLLLtvCGVVLMDFSADSADNPSHAYMMDVCSPADQDRGLNIHALLAGLGGGFGYVVGG 250
Cdd:cd06174    73 -------LGALLF--AFAPSFWLLL--LGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGG 141

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1829661190 251 IHWDKTGFGralggqLRVIYLFTAVTLSVTTVLTLVSIPERPLRPPSEK 299
Cdd:cd06174   142 ILASSLGFG------WRAVFLIAAALALLAAILLLLVVPDPPESARAKN 184
BtlA COG2270
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...
 118-229 3.36e-05

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];


Pssm-ID: 441871 [Multi-domain]  Cd Length: 424  Bit Score: 47.07  E-value: 3.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829661190 118 PDQLYSLVWFISPILGFLLQPLLGAWSDRCtsrfGRRRPFILVLAIGALLGLslllngrdigIALADVTGNhkwGLLLTV 197
Cdd:COG2270    50 ATALWGYALAIAGLLVALLAPVLGAIADRS----GRKKPFLAFFTLLGVLAT----------AALFFVAPG---GLWLGL 112

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1829661190 198 CGVVLMDFSADSADNPSHAYMMDVCSPADQDR 229
Cdd:COG2270   113 LLFVLANIGFEGSLVFYNAFLPDIATPEEIGR 144
MFS_2 pfam13347
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ...
 89-165 4.22e-04

MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.


Pssm-ID: 433134 [Multi-domain]  Cd Length: 427  Bit Score: 43.45  E-value: 4.22e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1829661190  89 FNGCILFGIEFSYAMETAYVTPVLLQ-MGLPDQLYSLVWFISPILGFLLQPLLGAWSDRCTSRFGRRRPFILVLAIGA 165
Cdd:pfam13347   1 GYGSGALAAGIKYAGLATYLLYFYTDvLGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTRTRWGRRRPWLLLSAIIL 78
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 89-163 1.18e-03

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 42.21  E-value: 1.18e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1829661190  89 FNGCILFGIEFSYAMEtaYVTPVllqMGLPDQLYSLVWFISPILGFLLQPLLGAWSDRCTSRFGRRRPFILVLAI 163
Cdd:cd17332     9 FGNNLIFQIVSTYLLF--FYTDV---LGLSAAAAGTIFLVARIIDAINDPLMGYLIDRTRSRWGRFRPWLLWGAI 78
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
574-711 2.52e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 41.04  E-value: 2.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829661190 574 YQKYNSGVTMGCWGMC--IYAFSAAFYSAILEKLEEFLSVRTLYFIAYLAFGLGTGLATLSR--NLYVVLSLCITYGILF 649
Cdd:COG2211   254 YFKYVLGLSAALVGLLlaLYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGpgNLWLLLVLAALAGIGL 333

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1829661190 650 STLCTLPYSLL---CDYYQSKKfagssadGTRRgMGVDISLLSCQYFLAQILVSLVLGPLTSAVG 711
Cdd:COG2211   334 GAILVLPWAMLadvVDYDEWKT-------GRRR-EGLYFGIFTFAIKLGQALAGALAGLLLALFG 390
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 77-227 2.72e-03

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 40.64  E-value: 2.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829661190  77 DLHPQRSFRELLFNGCIL--FGIEFSYAMETAYVTPVL-----LQMGLPDQLYSLVWFISPILGFLLQPLLGAWSDrcts 149
Cdd:cd17325   185 AARLRSGLRLLLRDRRLLalFLAIFVLAFAFGALEPFLplyaaELGGLSPAQIGLLFGAQGLASALSQPPAGKLSD---- 260

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1829661190 150 RFGRRRPFILVLAIGAllglslllngrdIGIALADVTGNHkWGLLLtvcGVVLMDFSADSADNPSHAYMMDVCSPADQ 227
Cdd:cd17325   261 RIGRKPLILIGLLLSA------------VALLLLPLATSF-WLLLL---LLALLGLGLGLVFPATLALLADIVPPEGR 322
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
85-231 2.96e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 40.73  E-value: 2.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829661190  85 RELLFNGCILFGIEFSYAMETAYVTPVLLQ-MGLPDQLYSLVWFISPILGFLLQPLLGAWSDrctsRFGRRRPFILVLAI 163
Cdd:COG2814   207 PRLLLLLLLAFLLGFGFFALFTYLPLYLQEvLGLSASAAGLLLALFGLGGVLGALLAGRLAD----RFGRRRLLLIGLLL 282

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1829661190 164 GAllglslllngrdIGIALADVTGNHkWGLLLtvcGVVLMDFSADSADNPSHAYMMDVCSPADQDRGL 231
Cdd:COG2814   283 LA------------LGLLLLALAGSL-WLLLL---ALFLLGFGFGLLFPLLQALVAELAPPEARGRAS 334
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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