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Conserved domains on  [gi|1829519642|ref|NP_001366513|]
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phosphatidylcholine:ceramide cholinephosphotransferase 2 [Mus musculus]

Protein Classification

sphingomyelin synthase family protein( domain architecture ID 10627211)

sphingomyelin synthase family protein belonging to the type 2 phosphatidic acid phosphatase (PAP2) superfamily, similar to phosphatidylinositol:ceramide inositolphosphotransferase that is capable of converting phosphatidylinositol (PI) and ceramide to inositol-phosphorylceramide (IPC) and diacylglycerol (DAG) and vice versa

CATH:  1.20.144.10
EC:  2.7.8.-
Gene Ontology:  GO:0016780|GO:0016310
PubMed:  9122162|14685263
SCOP:  3001110

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAP2_C pfam14360
PAP2 superfamily C-terminal; This family is closely related to the C-terminal a region of PAP2.
 220-293 8.57e-31

PAP2 superfamily C-terminal; This family is closely related to the C-terminal a region of PAP2.


:

Pssm-ID: 464150  Cd Length: 74  Bit Score: 111.92  E-value: 8.57e-31
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1829519642 220 LCGDFLFSGHTVVLTLTYLFIKEYSPRHFWWYHLVCWLLSAAGIICILVAHEHYTVDVIIAYYITTRLFWWYHS 293
Cdd:pfam14360   1 GCGDLIFSGHTVFTTLFVLFIWEYSPRRLWILKVILWLLAAIGYFLIIASRKHYTVDVLLGYYITTLVFLLYHT 74
 
Name Accession Description Interval E-value
PAP2_C pfam14360
PAP2 superfamily C-terminal; This family is closely related to the C-terminal a region of PAP2.
 220-293 8.57e-31

PAP2 superfamily C-terminal; This family is closely related to the C-terminal a region of PAP2.


Pssm-ID: 464150  Cd Length: 74  Bit Score: 111.92  E-value: 8.57e-31
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1829519642 220 LCGDFLFSGHTVVLTLTYLFIKEYSPRHFWWYHLVCWLLSAAGIICILVAHEHYTVDVIIAYYITTRLFWWYHS 293
Cdd:pfam14360   1 GCGDLIFSGHTVFTTLFVLFIWEYSPRRLWILKVILWLLAAIGYFLIIASRKHYTVDVLLGYYITTLVFLLYHT 74
acidPPc smart00014
Acid phosphatase homologues;
226-283 1.14e-03

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 38.48  E-value: 1.14e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519642  226 FSGHTVVLTLTYLFIKEYSPRHFWWYHLVCWLLSAAGIICI--LVAHEHYTVDVIIAYYI 283
Cdd:smart00014  48 PSGHTAFAFAFALFLLLYLPARAGRKLLIFLLLLLALVVGFsrVYLGAHWPSDVLAGSLL 107
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 227-292 6.76e-03

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 36.28  E-value: 6.76e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1829519642 227 SGHTVVLTLTYLFIKEYSPRHFWWYHLVCWLLSAAGIICI--LVAHEHYTVDVIIAYYITTRLFWWYH 292
Cdd:cd01610    55 SGHAAFAFALALFLALLLPRRLLRLLLGLLLLLLALLVGLsrVYLGVHYPSDVLAGALLGILVALLVL 122
 
Name Accession Description Interval E-value
PAP2_C pfam14360
PAP2 superfamily C-terminal; This family is closely related to the C-terminal a region of PAP2.
 220-293 8.57e-31

PAP2 superfamily C-terminal; This family is closely related to the C-terminal a region of PAP2.


Pssm-ID: 464150  Cd Length: 74  Bit Score: 111.92  E-value: 8.57e-31
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1829519642 220 LCGDFLFSGHTVVLTLTYLFIKEYSPRHFWWYHLVCWLLSAAGIICILVAHEHYTVDVIIAYYITTRLFWWYHS 293
Cdd:pfam14360   1 GCGDLIFSGHTVFTTLFVLFIWEYSPRRLWILKVILWLLAAIGYFLIIASRKHYTVDVLLGYYITTLVFLLYHT 74
acidPPc smart00014
Acid phosphatase homologues;
226-283 1.14e-03

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 38.48  E-value: 1.14e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519642  226 FSGHTVVLTLTYLFIKEYSPRHFWWYHLVCWLLSAAGIICI--LVAHEHYTVDVIIAYYI 283
Cdd:smart00014  48 PSGHTAFAFAFALFLLLYLPARAGRKLLIFLLLLLALVVGFsrVYLGAHWPSDVLAGSLL 107
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 227-292 6.76e-03

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 36.28  E-value: 6.76e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1829519642 227 SGHTVVLTLTYLFIKEYSPRHFWWYHLVCWLLSAAGIICI--LVAHEHYTVDVIIAYYITTRLFWWYH 292
Cdd:cd01610    55 SGHAAFAFALALFLALLLPRRLLRLLLGLLLLLLALLVGLsrVYLGVHYPSDVLAGALLGILVALLVL 122
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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