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Conserved domains on  [gi|1829519291|ref|NP_001366473|]
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transmembrane protein 144 isoform b [Mus musculus]

Protein Classification

L-rhamnose-proton symporter family protein( domain architecture ID 139974)

L-rhamnose-proton symporter family protein such as Escherichia coli RhaT, which is involved in uptake of L-rhamnose across the cytoplasmic membrane with the concomitant transport of protons into the cell

Gene Ontology:  GO:0015293|GO:0015144
PubMed:  1551902
TCDB:  2.A.7.6

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RhaT super family cl19288
L-rhamnose-proton symport protein (RhaT); This family consists of several bacterial ...
 1-125 4.07e-59

L-rhamnose-proton symport protein (RhaT); This family consists of several bacterial L-rhamnose-proton symport protein (RhaT) sequences.


The actual alignment was detected with superfamily member pfam07857:

Pssm-ID: 302813  Cd Length: 333  Bit Score: 184.94  E-value: 4.07e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519291   1 MYAGASQYDLDYVFAHSSGIFLTSTVYFVAYCVAMKNRPKLYPEAVLPGLLSGVLWAIATCCWFIANHSLSAVISFPIIT 80
Cdd:pfam07857 209 IYPGAPQDGLDYVFSHYTGIFLTSTVYFFAYSIVKKNNPYVPSELVLPSIGSGILWAIAMTSWFVANQKLSQVVSYPIIS 288

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1829519291  81 AGPGLIAALWGILIFKEIQGLRNYLLMMLAFCIILAGALCTAFSK 125
Cdd:pfam07857 289 RAPGLIAAAWSVFYFKEIQGKRNYILLGIASAITLIGAIMVALSK 333
 
Name Accession Description Interval E-value
TMEM144 pfam07857
Transmembrane family, TMEM144 of transporters; Members of this family fall in to the drug ...
 1-125 4.07e-59

Transmembrane family, TMEM144 of transporters; Members of this family fall in to the drug/metabolite transporter (dmt) superfamily. They carry 10xTM domains arranged as 5+5. Although these two sets may originally have arisen by gene-duplication the divergence now is such that the two halves are no longer homologous.


Pssm-ID: 285141  Cd Length: 333  Bit Score: 184.94  E-value: 4.07e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519291   1 MYAGASQYDLDYVFAHSSGIFLTSTVYFVAYCVAMKNRPKLYPEAVLPGLLSGVLWAIATCCWFIANHSLSAVISFPIIT 80
Cdd:pfam07857 209 IYPGAPQDGLDYVFSHYTGIFLTSTVYFFAYSIVKKNNPYVPSELVLPSIGSGILWAIAMTSWFVANQKLSQVVSYPIIS 288

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1829519291  81 AGPGLIAALWGILIFKEIQGLRNYLLMMLAFCIILAGALCTAFSK 125
Cdd:pfam07857 289 RAPGLIAAAWSVFYFKEIQGKRNYILLGIASAITLIGAIMVALSK 333
GRP cd23110
glucose/ribose porter family; The glucose/ribose porter (GRP) family (TC 2.A.7.5) includes two ...
 19-125 8.81e-10

glucose/ribose porter family; The glucose/ribose porter (GRP) family (TC 2.A.7.5) includes two functionally characterized members, a glucose uptake permease from Staphylococcus xylosus, and a probable ribose uptake permease from Lactobacillus sakei. Both proteins probably function by H(+) symport. This family also includes several putative and hypothetical membrane proteins that are probably involved in sugar transport across bacterial membranes. GRP family proteins have a distinctive topology: 10 putative transmembrane (TM) alpha-helical spanning domains per polypeptide chain, which apparently arose by intragenic duplication of an element encoding a primordial five-TM polypeptide. In Lactococcus lactis, GlcU was identified as the sole non-PTS (phosphoenolpyruvate:phosphotransferase systems) permease involved in the transport of glucose, which is driven by the proton-motive force. A gene from Bacillus subtilis, ycxE, that is homologous to glcU, could substitute for glcU in Escherichia coli glucose growth experiments and restored glucose repression in Staphylococcus xylosus glcU mutants. RbsU is encoded on the rbsUDK gene cluster, which encodes proteins involved in ribose uptake and phosphorylation. RbsR has been annotated as the repressor of the rbsUDK operon, based on its homology with RbsR repressors. The GRP family belongs to the Drug/Metabolite Transporter (DMT) superfamily (TC 2.A.7).


Pssm-ID: 438513 [Multi-domain]  Cd Length: 279  Bit Score: 54.39  E-value: 8.81e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519291  19 GIFLTSTVYFVAYcvamknRPKLYPEAVLPGLLSGVLWAIATCCWFIANHSLSAVISFPIITAGPGLIAALWGILIFKEI 98
Cdd:cd23110    34 GALIVALVVFLFL------GPTISPTLFLLAFLSGAFWSIGQIGQFKAFKRIGVSRTMPISTGLQLVGTSLIGVLLFGEW 107

                          90       100
                  ....*....|....*....|....*..
gi 1829519291  99 QGLRNYLLMMLAFCIILAGALCTAFSK 125
Cdd:cd23110   108 SGTGAKLLGLLALALIIIGVLLTSYTD 134
GlcU COG4975
Glucose uptake protein GlcU [Carbohydrate transport and metabolism];
28-125 9.65e-09

Glucose uptake protein GlcU [Carbohydrate transport and metabolism];


Pssm-ID: 444000 [Multi-domain]  Cd Length: 288  Bit Score: 51.78  E-value: 9.65e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519291  28 FVAYCVAMKNRPKLYPEAVLPGLLSGVLWAIATCCWFIANHSLSAVISFPIITAGPGLIAALWGILIFKEIQGLRNYLLM 107
Cdd:COG4975    41 IFAIIVFLFVQPELTGTIFIIGFLSGLFWAVGQINQFKSFKLLGVSKAMPISTGMQLVGTSLFGVILFGEWTTTTAKVLG 120

                          90
                  ....*....|....*...
gi 1829519291 108 MLAFCIILAGALCTAFSK 125
Cdd:COG4975   121 FLALILIIIGAVLTSYQD 138
 
Name Accession Description Interval E-value
TMEM144 pfam07857
Transmembrane family, TMEM144 of transporters; Members of this family fall in to the drug ...
 1-125 4.07e-59

Transmembrane family, TMEM144 of transporters; Members of this family fall in to the drug/metabolite transporter (dmt) superfamily. They carry 10xTM domains arranged as 5+5. Although these two sets may originally have arisen by gene-duplication the divergence now is such that the two halves are no longer homologous.


Pssm-ID: 285141  Cd Length: 333  Bit Score: 184.94  E-value: 4.07e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519291   1 MYAGASQYDLDYVFAHSSGIFLTSTVYFVAYCVAMKNRPKLYPEAVLPGLLSGVLWAIATCCWFIANHSLSAVISFPIIT 80
Cdd:pfam07857 209 IYPGAPQDGLDYVFSHYTGIFLTSTVYFFAYSIVKKNNPYVPSELVLPSIGSGILWAIAMTSWFVANQKLSQVVSYPIIS 288

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1829519291  81 AGPGLIAALWGILIFKEIQGLRNYLLMMLAFCIILAGALCTAFSK 125
Cdd:pfam07857 289 RAPGLIAAAWSVFYFKEIQGKRNYILLGIASAITLIGAIMVALSK 333
GRP cd23110
glucose/ribose porter family; The glucose/ribose porter (GRP) family (TC 2.A.7.5) includes two ...
 19-125 8.81e-10

glucose/ribose porter family; The glucose/ribose porter (GRP) family (TC 2.A.7.5) includes two functionally characterized members, a glucose uptake permease from Staphylococcus xylosus, and a probable ribose uptake permease from Lactobacillus sakei. Both proteins probably function by H(+) symport. This family also includes several putative and hypothetical membrane proteins that are probably involved in sugar transport across bacterial membranes. GRP family proteins have a distinctive topology: 10 putative transmembrane (TM) alpha-helical spanning domains per polypeptide chain, which apparently arose by intragenic duplication of an element encoding a primordial five-TM polypeptide. In Lactococcus lactis, GlcU was identified as the sole non-PTS (phosphoenolpyruvate:phosphotransferase systems) permease involved in the transport of glucose, which is driven by the proton-motive force. A gene from Bacillus subtilis, ycxE, that is homologous to glcU, could substitute for glcU in Escherichia coli glucose growth experiments and restored glucose repression in Staphylococcus xylosus glcU mutants. RbsU is encoded on the rbsUDK gene cluster, which encodes proteins involved in ribose uptake and phosphorylation. RbsR has been annotated as the repressor of the rbsUDK operon, based on its homology with RbsR repressors. The GRP family belongs to the Drug/Metabolite Transporter (DMT) superfamily (TC 2.A.7).


Pssm-ID: 438513 [Multi-domain]  Cd Length: 279  Bit Score: 54.39  E-value: 8.81e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519291  19 GIFLTSTVYFVAYcvamknRPKLYPEAVLPGLLSGVLWAIATCCWFIANHSLSAVISFPIITAGPGLIAALWGILIFKEI 98
Cdd:cd23110    34 GALIVALVVFLFL------GPTISPTLFLLAFLSGAFWSIGQIGQFKAFKRIGVSRTMPISTGLQLVGTSLIGVLLFGEW 107

                          90       100
                  ....*....|....*....|....*..
gi 1829519291  99 QGLRNYLLMMLAFCIILAGALCTAFSK 125
Cdd:cd23110   108 SGTGAKLLGLLALALIIIGVLLTSYTD 134
GlcU COG4975
Glucose uptake protein GlcU [Carbohydrate transport and metabolism];
28-125 9.65e-09

Glucose uptake protein GlcU [Carbohydrate transport and metabolism];


Pssm-ID: 444000 [Multi-domain]  Cd Length: 288  Bit Score: 51.78  E-value: 9.65e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519291  28 FVAYCVAMKNRPKLYPEAVLPGLLSGVLWAIATCCWFIANHSLSAVISFPIITAGPGLIAALWGILIFKEIQGLRNYLLM 107
Cdd:COG4975    41 IFAIIVFLFVQPELTGTIFIIGFLSGLFWAVGQINQFKSFKLLGVSKAMPISTGMQLVGTSLFGVILFGEWTTTTAKVLG 120

                          90
                  ....*....|....*...
gi 1829519291 108 MLAFCIILAGALCTAFSK 125
Cdd:COG4975   121 FLALILIIIGAVLTSYQD 138
GRP cd23110
glucose/ribose porter family; The glucose/ribose porter (GRP) family (TC 2.A.7.5) includes two ...
 19-121 3.69e-07

glucose/ribose porter family; The glucose/ribose porter (GRP) family (TC 2.A.7.5) includes two functionally characterized members, a glucose uptake permease from Staphylococcus xylosus, and a probable ribose uptake permease from Lactobacillus sakei. Both proteins probably function by H(+) symport. This family also includes several putative and hypothetical membrane proteins that are probably involved in sugar transport across bacterial membranes. GRP family proteins have a distinctive topology: 10 putative transmembrane (TM) alpha-helical spanning domains per polypeptide chain, which apparently arose by intragenic duplication of an element encoding a primordial five-TM polypeptide. In Lactococcus lactis, GlcU was identified as the sole non-PTS (phosphoenolpyruvate:phosphotransferase systems) permease involved in the transport of glucose, which is driven by the proton-motive force. A gene from Bacillus subtilis, ycxE, that is homologous to glcU, could substitute for glcU in Escherichia coli glucose growth experiments and restored glucose repression in Staphylococcus xylosus glcU mutants. RbsU is encoded on the rbsUDK gene cluster, which encodes proteins involved in ribose uptake and phosphorylation. RbsR has been annotated as the repressor of the rbsUDK operon, based on its homology with RbsR repressors. The GRP family belongs to the Drug/Metabolite Transporter (DMT) superfamily (TC 2.A.7).


Pssm-ID: 438513 [Multi-domain]  Cd Length: 279  Bit Score: 47.07  E-value: 3.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519291  19 GIFLTSTVYFVAycvaMKNRPKLYPEAVLPGLLSGVLWAIATCCWFIANHSLSAVISFPIITAGPgLIAALWGILIFKEI 98
Cdd:cd23110   182 GMLLGALIYALF----TRKPKALKEKASWRNILTGLLWGIANLAYLLSAQANGVATAFTLSQLNV-VISTLGGILILHEK 256

                          90       100
                  ....*....|....*....|...
gi 1829519291  99 QGLRNYLLMMLAFCIILAGALCT 121
Cdd:cd23110   257 KTKRELRFTLIGLVLIVAGAVLT 279
GlcU COG4975
Glucose uptake protein GlcU [Carbohydrate transport and metabolism];
10-125 2.80e-05

Glucose uptake protein GlcU [Carbohydrate transport and metabolism];


Pssm-ID: 444000 [Multi-domain]  Cd Length: 288  Bit Score: 41.77  E-value: 2.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519291  10 LDYVFAHSSGIFLTSTVYfvaycVAMKNRPKLYPEAVLPGLLSGVLWAIATCCWFIANHSLSAVISFPIITAGPgLIAAL 89
Cdd:COG4975   178 WSAFLPQAIGMLIGALIL-----SLKSKGSKFFEKKTYKNIITGLIWAIGNLFMLISAQANGVATGFSLSQMGV-VISTL 251

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1829519291  90 WGILIFKEIQGLRNYLLMMLAFCIILAGALCTAFSK 125
Cdd:COG4975   252 GGILILGEKKTKKEMIYTIIGLVLIVAGGILIGILK 287
Sugar_transport pfam06800
Sugar transport protein; This is a family of bacterial sugar transporters approximately 300 ...
 49-125 1.30e-04

Sugar transport protein; This is a family of bacterial sugar transporters approximately 300 residues long. Members include glucose uptake proteins, ribose transport proteins, and several putative and hypothetical membrane proteins probably involved in sugar transport across bacterial membranes. These members are transmembrane proteins which are usually 5+5 duplications. This model recognizes a set of five TMs,


Pssm-ID: 429127 [Multi-domain]  Cd Length: 280  Bit Score: 39.94  E-value: 1.30e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1829519291  49 GLLSGVLWAIATCCWFIANHSLSAVISFPIITAGPGLIAALWGILIFKEIQGLRNYLLMMLAFCIILAGALCTAFSK 125
Cdd:pfam06800  58 GFISGAFWAFGQIGQFKSFKLVGVSKAMPISTGMQLVGTSLFGVFAFGEWSTIIQKILGFLALILIVIGIYLTSWTE 134
ribose_uptake_RbsU cd23111
ribose uptake protein RbsU and similar proteins; This group includes ribose uptake protein ...
 29-124 1.46e-03

ribose uptake protein RbsU and similar proteins; This group includes ribose uptake protein RbsU and similar proteins. RbsU is encoded on the rbsUDK gene cluster, which encodes proteins involved in ribose uptake and phosphorylation. RbsR has been annotated as the repressor of the rbsUDK operon, based on its homology with RbsR repressors. RbsU belongs to the glucose/ribose porter (GRP) family (TC 2.A.7.5) and probably functions by H(+) symport. GRP family proteins have a distinctive topology: 10 putative transmembrane (TM) alpha-helical spanning domains per polypeptide chain, which apparently arose by intragenic duplication of an element encoding a primordial five-TM polypeptide. The GRP family belongs to the Drug/Metabolite Transporter (DMT) superfamily (TC 2.A.7).


Pssm-ID: 438514 [Multi-domain]  Cd Length: 285  Bit Score: 36.69  E-value: 1.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519291  29 VAYCVAMKNRPKLY-PEAVLPGLLSGVLWAIATCCWFIANHSLSAVISFPIITAGPGLIAALWGILIFKEIQGLRNYLLM 107
Cdd:cd23111    38 VAIVVALITGPPLPtGSDFLLSFLSGAGWAFGQILQFKAFTLIGVSRAMPISTGFQLIGTSLWGVIFLGEWPSLTAKIIG 117

                          90
                  ....*....|....*..
gi 1829519291 108 MLAFCIILAGALCTAFS 124
Cdd:cd23111   118 FLALILIIIGAYLTTWS 134
Sugar_transport pfam06800
Sugar transport protein; This is a family of bacterial sugar transporters approximately 300 ...
 28-123 3.39e-03

Sugar transport protein; This is a family of bacterial sugar transporters approximately 300 residues long. Members include glucose uptake proteins, ribose transport proteins, and several putative and hypothetical membrane proteins probably involved in sugar transport across bacterial membranes. These members are transmembrane proteins which are usually 5+5 duplications. This model recognizes a set of five TMs,


Pssm-ID: 429127 [Multi-domain]  Cd Length: 280  Bit Score: 35.71  E-value: 3.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829519291  28 FVAYCVAMKNRPKLYPEAVLPGLLSGVLWAIATCCWFIANHSLSAVISFPIITAGPgLIAALWGILIFKEIQGLRNYLLM 107
Cdd:pfam06800 185 IGALIFALFHKTAFFEKVTYLNIIPGLFWAIGNLFMLISAQMVGVATGFSLSQLGV-VISTIGGIFFLGEKKTKKEMVFV 263

                          90
                  ....*....|....*.
gi 1829519291 108 MLAFCIILAGALCTAF 123
Cdd:pfam06800 264 IIGILLIVVGAVLLGL 279
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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