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Conserved domains on  [gi|1828054637|ref|NP_001366397|]
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centrosomal protein of 19 kDa isoform 2 [Homo sapiens]

Protein Classification

CEP19 domain-containing protein( domain architecture ID 10633083)

CEP19 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CEP19 pfam14933
CEP19-like protein; This family includes the centrosomal protein of 19 kDa found in eukaryotes. ...
 9-121 1.65e-50

CEP19-like protein; This family includes the centrosomal protein of 19 kDa found in eukaryotes. In humans, it is encoded for by the gene CEP19 which is also known as C3orf34. These proteins localize in the centrosomes. Centrosomes are dynamic organelles that assemble around the centrioles. They organize the microtubule cytoskeleton and mitotic spindle apparatus and are required for cell division and cell migration. C3orf34 localizes near the centrosome in early interphase, to spindle poles during mitosis, and to distinct foci oriented towards the midbody at telophase.


:

Pssm-ID: 373400  Cd Length: 150  Bit Score: 157.49  E-value: 1.65e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828054637   9 DCTRAAEQLKNNPRHKSYLEQVSLRQLEKLFSFL-RGYLSGQSLAETMEQIQRETTIDPEEDLNKLDDKELAKRKSIMDE 87
Cdd:pfam14933  39 DVARLAERLKKNPRHKSYLERVSLLQLEKLIGLLtQDSLPGPSLDENLEEIKQEADLDPNEDLNKLDDKELQRFKELMDE 118

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1828054637  88 LFEKNQKKKDDPNFVYDIEVEFPQDDqlQSCGWD 121
Cdd:pfam14933 119 LFEKNRIKPGDPDFVYDKEVDFGKPD--QSSSWD 150
 
Name Accession Description Interval E-value
CEP19 pfam14933
CEP19-like protein; This family includes the centrosomal protein of 19 kDa found in eukaryotes. ...
 9-121 1.65e-50

CEP19-like protein; This family includes the centrosomal protein of 19 kDa found in eukaryotes. In humans, it is encoded for by the gene CEP19 which is also known as C3orf34. These proteins localize in the centrosomes. Centrosomes are dynamic organelles that assemble around the centrioles. They organize the microtubule cytoskeleton and mitotic spindle apparatus and are required for cell division and cell migration. C3orf34 localizes near the centrosome in early interphase, to spindle poles during mitosis, and to distinct foci oriented towards the midbody at telophase.


Pssm-ID: 373400  Cd Length: 150  Bit Score: 157.49  E-value: 1.65e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828054637   9 DCTRAAEQLKNNPRHKSYLEQVSLRQLEKLFSFL-RGYLSGQSLAETMEQIQRETTIDPEEDLNKLDDKELAKRKSIMDE 87
Cdd:pfam14933  39 DVARLAERLKKNPRHKSYLERVSLLQLEKLIGLLtQDSLPGPSLDENLEEIKQEADLDPNEDLNKLDDKELQRFKELMDE 118

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1828054637  88 LFEKNQKKKDDPNFVYDIEVEFPQDDqlQSCGWD 121
Cdd:pfam14933 119 LFEKNRIKPGDPDFVYDKEVDFGKPD--QSSSWD 150
 
Name Accession Description Interval E-value
CEP19 pfam14933
CEP19-like protein; This family includes the centrosomal protein of 19 kDa found in eukaryotes. ...
 9-121 1.65e-50

CEP19-like protein; This family includes the centrosomal protein of 19 kDa found in eukaryotes. In humans, it is encoded for by the gene CEP19 which is also known as C3orf34. These proteins localize in the centrosomes. Centrosomes are dynamic organelles that assemble around the centrioles. They organize the microtubule cytoskeleton and mitotic spindle apparatus and are required for cell division and cell migration. C3orf34 localizes near the centrosome in early interphase, to spindle poles during mitosis, and to distinct foci oriented towards the midbody at telophase.


Pssm-ID: 373400  Cd Length: 150  Bit Score: 157.49  E-value: 1.65e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1828054637   9 DCTRAAEQLKNNPRHKSYLEQVSLRQLEKLFSFL-RGYLSGQSLAETMEQIQRETTIDPEEDLNKLDDKELAKRKSIMDE 87
Cdd:pfam14933  39 DVARLAERLKKNPRHKSYLERVSLLQLEKLIGLLtQDSLPGPSLDENLEEIKQEADLDPNEDLNKLDDKELQRFKELMDE 118

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1828054637  88 LFEKNQKKKDDPNFVYDIEVEFPQDDqlQSCGWD 121
Cdd:pfam14933 119 LFEKNRIKPGDPDFVYDKEVDFGKPD--QSSSWD 150
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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