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Conserved domains on  [gi|1824614762|ref|NP_001366159|]
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EARP and GARP complex-interacting protein 1 isoform b [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 35-273 1.57e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 97.02  E-value: 1.57e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824614762  35 GNVACVVWEPmgDGKKVISL-ADSHILLWDLQPSSSQAvlassaTLEGRgQLKFTAGRWSPHHNctQVATAS-DTTLRGW 112
Cdd:cd00200    10 GGVTCVAFSP--DGKLLATGsGDGTIKVWDLETGELLR------TLKGH-TGPVRDVAASADGT--YLASGSsDKTIRLW 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824614762 113 DTRSMSQIYCIEnAHGQLVRDLDFNPNKQYyLASCGDDCKVKFWDTRNvTEPVKTLEEHSHWVWSVRYNHShDQLVLTGS 192
Cdd:cd00200    79 DLETGECVRTLT-GHTSYVSSVAFSPDGRI-LSSSSRDKTIKVWDVET-GKCLTTLRGHTDWVNSVAFSPD-GTFVASSS 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824614762 193 SDSRVILSNMVSIS-----------------SEPFGHLV---DDGDIsdpeehhaeKSKEPLQDNVIATYEEHEDSVYAV 252
Cdd:cd00200   155 QDGTIKLWDLRTGKcvatltghtgevnsvafSPDGEKLLsssSDGTI---------KLWDLSTGKCLGTLRGHENGVNSV 225

                         250       260
                  ....*....|....*....|.
gi 1824614762 253 DWaSADPWLFASLSYDGRLVI 273
Cdd:cd00200   226 AF-SPDGYLLASGSEDGTIRV 245
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 35-273 1.57e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 97.02  E-value: 1.57e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824614762  35 GNVACVVWEPmgDGKKVISL-ADSHILLWDLQPSSSQAvlassaTLEGRgQLKFTAGRWSPHHNctQVATAS-DTTLRGW 112
Cdd:cd00200    10 GGVTCVAFSP--DGKLLATGsGDGTIKVWDLETGELLR------TLKGH-TGPVRDVAASADGT--YLASGSsDKTIRLW 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824614762 113 DTRSMSQIYCIEnAHGQLVRDLDFNPNKQYyLASCGDDCKVKFWDTRNvTEPVKTLEEHSHWVWSVRYNHShDQLVLTGS 192
Cdd:cd00200    79 DLETGECVRTLT-GHTSYVSSVAFSPDGRI-LSSSSRDKTIKVWDVET-GKCLTTLRGHTDWVNSVAFSPD-GTFVASSS 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824614762 193 SDSRVILSNMVSIS-----------------SEPFGHLV---DDGDIsdpeehhaeKSKEPLQDNVIATYEEHEDSVYAV 252
Cdd:cd00200   155 QDGTIKLWDLRTGKcvatltghtgevnsvafSPDGEKLLsssSDGTI---------KLWDLSTGKCLGTLRGHENGVNSV 225

                         250       260
                  ....*....|....*....|.
gi 1824614762 253 DWaSADPWLFASLSYDGRLVI 273
Cdd:cd00200   226 AF-SPDGYLLASGSEDGTIRV 245
WD40 COG2319
WD40 repeat [General function prediction only];
34-277 1.07e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 88.04  E-value: 1.07e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824614762  34 QGNVACVVWEPmgDGKKVISL-ADSHILLWDLQpsSSQAVlassATLEGRGQLkFTAGRWSPHHNctQVATAS-DTTLRG 111
Cdd:COG2319   162 SGAVTSVAFSP--DGKLLASGsDDGTVRLWDLA--TGKLL----RTLTGHTGA-VRSVAFSPDGK--LLASGSaDGTVRL 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824614762 112 WDTRSMSQIYCIEnAHGQLVRDLDFNPNKQYyLASCGDDCKVKFWDTRNvTEPVKTLEEHSHWVWSVRYnhSHD-QLVLT 190
Cdd:COG2319   231 WDLATGKLLRTLT-GHSGSVRSVAFSPDGRL-LASGSADGTVRLWDLAT-GELLRTLTGHSGGVNSVAF--SPDgKLLAS 305

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824614762 191 GSSDSRVIL---------------SNMV-SISSEPFGHLV----DDG-----DISDPEEhhaekskeplqdnvIATYEEH 245
Cdd:COG2319   306 GSDDGTVRLwdlatgkllrtltghTGAVrSVAFSPDGKTLasgsDDGtvrlwDLATGEL--------------LRTLTGH 371

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1824614762 246 EDSVYAVDWASADPWLfASLSYDGRLVINRVP 277
Cdd:COG2319   372 TGAVTSVAFSPDGRTL-ASGSADGTVRLWDLA 402
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 125-157 3.10e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 3.10e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1824614762  125 NAHGQLVRDLDFNPNKQYyLASCGDDCKVKFWD 157
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
125-157 1.06e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 1.06e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1824614762 125 NAHGQLVRDLDFNPNKQYyLASCGDDCKVKFWD 157
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 104-160 1.13e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 40.32  E-value: 1.13e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1824614762 104 ASDTTLRGWDTR----SMSQI---YCIENAHGQLVRDLDFNPNKQYYLASCGDDCKVKFWDTRN 160
Cdd:PTZ00420   94 SEDLTIRVWEIPhndeSVKEIkdpQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIEN 157
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 35-273 1.57e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 97.02  E-value: 1.57e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824614762  35 GNVACVVWEPmgDGKKVISL-ADSHILLWDLQPSSSQAvlassaTLEGRgQLKFTAGRWSPHHNctQVATAS-DTTLRGW 112
Cdd:cd00200    10 GGVTCVAFSP--DGKLLATGsGDGTIKVWDLETGELLR------TLKGH-TGPVRDVAASADGT--YLASGSsDKTIRLW 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824614762 113 DTRSMSQIYCIEnAHGQLVRDLDFNPNKQYyLASCGDDCKVKFWDTRNvTEPVKTLEEHSHWVWSVRYNHShDQLVLTGS 192
Cdd:cd00200    79 DLETGECVRTLT-GHTSYVSSVAFSPDGRI-LSSSSRDKTIKVWDVET-GKCLTTLRGHTDWVNSVAFSPD-GTFVASSS 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824614762 193 SDSRVILSNMVSIS-----------------SEPFGHLV---DDGDIsdpeehhaeKSKEPLQDNVIATYEEHEDSVYAV 252
Cdd:cd00200   155 QDGTIKLWDLRTGKcvatltghtgevnsvafSPDGEKLLsssSDGTI---------KLWDLSTGKCLGTLRGHENGVNSV 225

                         250       260
                  ....*....|....*....|.
gi 1824614762 253 DWaSADPWLFASLSYDGRLVI 273
Cdd:cd00200   226 AF-SPDGYLLASGSEDGTIRV 245
WD40 COG2319
WD40 repeat [General function prediction only];
34-277 1.07e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 88.04  E-value: 1.07e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824614762  34 QGNVACVVWEPmgDGKKVISL-ADSHILLWDLQpsSSQAVlassATLEGRGQLkFTAGRWSPHHNctQVATAS-DTTLRG 111
Cdd:COG2319   162 SGAVTSVAFSP--DGKLLASGsDDGTVRLWDLA--TGKLL----RTLTGHTGA-VRSVAFSPDGK--LLASGSaDGTVRL 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824614762 112 WDTRSMSQIYCIEnAHGQLVRDLDFNPNKQYyLASCGDDCKVKFWDTRNvTEPVKTLEEHSHWVWSVRYnhSHD-QLVLT 190
Cdd:COG2319   231 WDLATGKLLRTLT-GHSGSVRSVAFSPDGRL-LASGSADGTVRLWDLAT-GELLRTLTGHSGGVNSVAF--SPDgKLLAS 305

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824614762 191 GSSDSRVIL---------------SNMV-SISSEPFGHLV----DDG-----DISDPEEhhaekskeplqdnvIATYEEH 245
Cdd:COG2319   306 GSDDGTVRLwdlatgkllrtltghTGAVrSVAFSPDGKTLasgsDDGtvrlwDLATGEL--------------LRTLTGH 371

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1824614762 246 EDSVYAVDWASADPWLfASLSYDGRLVINRVP 277
Cdd:COG2319   372 TGAVTSVAFSPDGRTL-ASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
47-273 2.25e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 78.41  E-value: 2.25e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824614762  47 DGKKVISLA-DSHILLWDLQPSSSQAVLASSATlegrgqlKFTAGRWSPhhNCTQVATAS-DTTLRGWDTRSMSQIYCIE 124
Cdd:COG2319    89 DGRLLASASaDGTVRLWDLATGLLLRTLTGHTG-------AVRSVAFSP--DGKTLASGSaDGTVRLWDLATGKLLRTLT 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824614762 125 nAHGQLVRDLDFNPNKQYyLASCGDDCKVKFWDTRNvTEPVKTLEEHSHWVWSVRYnhSHD-QLVLTGSSDSRVILSNmv 203
Cdd:COG2319   160 -GHSGAVTSVAFSPDGKL-LASGSDDGTVRLWDLAT-GKLLRTLTGHTGAVRSVAF--SPDgKLLASGSADGTVRLWD-- 232

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824614762 204 sissepfghlVDDGDisdpeehhaekskeplqdnVIATYEEHEDSVYAVDWaSADPWLFASLSYDGRLVI 273
Cdd:COG2319   233 ----------LATGK-------------------LLRTLTGHSGSVRSVAF-SPDGRLLASGSADGTVRL 272
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 37-199 3.60e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.60  E-value: 3.60e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824614762  37 VACVVWEPmgdGKKVI--SLADSHILLWDLQPSSSQAvlassaTLEG-RGQLKFTAgrWSPhhNCTQVATAS-DTTLRGW 112
Cdd:cd00200   138 VNSVAFSP---DGTFVasSSQDGTIKLWDLRTGKCVA------TLTGhTGEVNSVA--FSP--DGEKLLSSSsDGTIKLW 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824614762 113 DTRSMSQIYCIEnAHGQLVRDLDFNPNKqYYLASCGDDCKVKFWDTRNvTEPVKTLEEHSHWVWSVRYnHSHDQLVLTGS 192
Cdd:cd00200   205 DLSTGKCLGTLR-GHENGVNSVAFSPDG-YLLASGSEDGTIRVWDLRT-GECVQTLSGHTNSVTSLAW-SPDGKRLASGS 280


                  ....*..
gi 1824614762 193 SDSRVIL 199
Cdd:cd00200   281 ADGTIRI 287
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 127-273 4.06e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 65.05  E-value: 4.06e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824614762 127 HGQLVRDLDFNPNKQYyLASCGDDCKVKFWDTRNvTEPVKTLEEHSHWVWSVRYnHSHDQLVLTGSSDSRVILSnmvsis 206
Cdd:cd00200     8 HTGGVTCVAFSPDGKL-LATGSGDGTIKVWDLET-GELLRTLKGHTGPVRDVAA-SADGTYLASGSSDKTIRLW------ 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1824614762 207 sepfghlvddgDISDPEEHHaekskeplqdnviaTYEEHEDSVYAVDWASADPWLFASlSYDGRLVI 273
Cdd:cd00200    79 -----------DLETGECVR--------------TLTGHTSYVSSVAFSPDGRILSSS-SRDKTIKV 119
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 34-157 1.73e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 60.43  E-value: 1.73e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824614762  34 QGNVACVVWEPmgDGKKVISLA-DSHILLWDLQPSssqavlASSATLEGRGQlKFTAGRWSPHHNcTQVATASDTTLRGW 112
Cdd:cd00200   177 TGEVNSVAFSP--DGEKLLSSSsDGTIKLWDLSTG------KCLGTLRGHEN-GVNSVAFSPDGY-LLASGSEDGTIRVW 246

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1824614762 113 DTRSMSQIYCIEnAHGQLVRDLDFNPNKQYyLASCGDDCKVKFWD 157
Cdd:cd00200   247 DLRTGECVQTLS-GHTNSVTSLAWSPDGKR-LASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
35-160 6.84e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 52.99  E-value: 6.84e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1824614762  35 GNVACVVWEPmgDGKKVISL-ADSHILLWDLqpsSSQAVLAssaTLEGRGQlKFTAGRWSPhhNCTQVATAS-DTTLRGW 112
Cdd:COG2319   289 GGVNSVAFSP--DGKLLASGsDDGTVRLWDL---ATGKLLR---TLTGHTG-AVRSVAFSP--DGKTLASGSdDGTVRLW 357

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1824614762 113 DTRSMSQIYCIEnAHGQLVRDLDFNPNKQYyLASCGDDCKVKFWDTRN 160
Cdd:COG2319   358 DLATGELLRTLT-GHTGAVTSVAFSPDGRT-LASGSADGTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 125-157 3.10e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 3.10e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1824614762  125 NAHGQLVRDLDFNPNKQYyLASCGDDCKVKFWD 157
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
125-157 1.06e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 1.06e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1824614762 125 NAHGQLVRDLDFNPNKQYyLASCGDDCKVKFWD 157
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 104-160 1.13e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 40.32  E-value: 1.13e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1824614762 104 ASDTTLRGWDTR----SMSQI---YCIENAHGQLVRDLDFNPNKQYYLASCGDDCKVKFWDTRN 160
Cdd:PTZ00420   94 SEDLTIRVWEIPhndeSVKEIkdpQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIEN 157
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 163-199 1.95e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 1.95e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1824614762  163 EPVKTLEEHSHWVWSVRYnHSHDQLVLTGSSDSRVIL 199
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAF-SPDGKYLASGSDDGTIKL 38
WD40 pfam00400
WD domain, G-beta repeat;
163-199 3.62e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.63  E-value: 3.62e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1824614762 163 EPVKTLEEHSHWVWSVRYnHSHDQLVLTGSSDSRVIL 199
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAF-SPDGKLLASGSDDGTVKV 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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