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Conserved domains on  [gi|1823752927|ref|NP_001366035|]
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PR domain zinc finger protein 5 isoform 5 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PR-SET_PRDM5 cd19190
PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 ...
 2-128 7.71e-98

PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 (also termed PR domain-containing protein 5) is a sequence-specific DNA-binding transcription factor that represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1.


:

Pssm-ID: 380967  Cd Length: 127  Bit Score: 293.04  E-value: 7.71e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752927   2 LGMYVPDRFSLKSSRVQDGMGLYTARRVRKGEKFGPFAGEKRMPEDLDENMDYRLMWEVRGSKGEVLYILDATNPRHSNW 81
Cdd:cd19190     1 LGMYVPDRFSLKSSKVQDGMGLYTARRVKKGEKFGPFAGEKRMPNELDESMDPRLMWEVRGSKGEVLYILDASNPRHSNW 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1823752927  82 LRFVHEAPSQEQKNLAAIQEGENIFYLAVEDIETDTELLIGYLDSDM 128
Cdd:cd19190    81 LRFVHEAPSQEQKNLAAIQEGENIFYLAVDDIETDTELLIGYLDSDM 127
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
145-337 8.65e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.70  E-value: 8.65e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752927 145 EVENSRRQSTAGRKDRLGCKEDYACPQCESSFTSEDILAEHLQTLHQKPTEEKEFKC--KNCGKKFPVKQALQRHFEQHq 222
Cdd:COG5048   268 ASSQSSSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSVNHSGESLKPFSCpySLCGKLFSRNDALKRHILLH- 346

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752927 223 etcRGDARFVCKADSCGKRLKSKDALKRHQ--ENVHTGDPKKKLICSV--CNKKCSSASSLQEHRKIH-----EIFDCQE 293
Cdd:COG5048   347 ---TSISPAKEKLLNSSSKFSPLLNNEPPQslQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHlsfrpYNCKNPP 423

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1823752927 294 CMKKFISANQLKRHMITHSEKRPYNCEICNKSFKRLDQVGAHKV 337
Cdd:COG5048   424 CSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
298-488 6.43e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.46  E-value: 6.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752927 298 FISANQLKRHMITHSEKR-PYNCEICNKSFKRLDQVGAHK--VIHS--EDKPYKC--KLCGKGFAHRNVYKNHKKTHSEE 370
Cdd:COG5048   270 SQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLrsVNHSgeSLKPFSCpySLCGKLFSRNDALKRHILLHTSI 349

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752927 371 RPFQCeeckaLFRTPFSLQRHLLIHNSERTFkCHHCDATFKRKDTLNVHvqvvherhkkyrceLCNKAFVTPSVLRSHKK 450
Cdd:COG5048   350 SPAKE-----KLLNSSSKFSPLLNNEPPQSL-QQYKDLKNDKKSETLSN--------------SCIRNFKRDSNLSLHII 409

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1823752927 451 THT--GEKEKICPYCGQKFASSGTLRVHIRSHTGERPYQC 488
Cdd:COG5048   410 THLsfRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC 449
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 482-559 9.22e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.09  E-value: 9.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752927 482 GERPYQCPY--CEKGFSKNDGLKMHiRTHTRvCDLAFSLKKMLIRHKMTHNPNRPLaECQFCHKKFTRNDYLKVHMDNIH 559
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYH-MLHGH-QNQKLHENPSPEKMNIFSAKDKPY-RCEVCDKRYKNLNGLKYHRKHSH 422
 
Name Accession Description Interval E-value
PR-SET_PRDM5 cd19190
PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 ...
 2-128 7.71e-98

PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 (also termed PR domain-containing protein 5) is a sequence-specific DNA-binding transcription factor that represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1.


Pssm-ID: 380967  Cd Length: 127  Bit Score: 293.04  E-value: 7.71e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752927   2 LGMYVPDRFSLKSSRVQDGMGLYTARRVRKGEKFGPFAGEKRMPEDLDENMDYRLMWEVRGSKGEVLYILDATNPRHSNW 81
Cdd:cd19190     1 LGMYVPDRFSLKSSKVQDGMGLYTARRVKKGEKFGPFAGEKRMPNELDESMDPRLMWEVRGSKGEVLYILDASNPRHSNW 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1823752927  82 LRFVHEAPSQEQKNLAAIQEGENIFYLAVEDIETDTELLIGYLDSDM 128
Cdd:cd19190    81 LRFVHEAPSQEQKNLAAIQEGENIFYLAVDDIETDTELLIGYLDSDM 127
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
145-337 8.65e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.70  E-value: 8.65e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752927 145 EVENSRRQSTAGRKDRLGCKEDYACPQCESSFTSEDILAEHLQTLHQKPTEEKEFKC--KNCGKKFPVKQALQRHFEQHq 222
Cdd:COG5048   268 ASSQSSSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSVNHSGESLKPFSCpySLCGKLFSRNDALKRHILLH- 346

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752927 223 etcRGDARFVCKADSCGKRLKSKDALKRHQ--ENVHTGDPKKKLICSV--CNKKCSSASSLQEHRKIH-----EIFDCQE 293
Cdd:COG5048   347 ---TSISPAKEKLLNSSSKFSPLLNNEPPQslQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHlsfrpYNCKNPP 423

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1823752927 294 CMKKFISANQLKRHMITHSEKRPYNCEICNKSFKRLDQVGAHKV 337
Cdd:COG5048   424 CSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 20-130 1.77e-07

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 50.03  E-value: 1.77e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752927   20 GMGLYTARRVRKGEKFGPFAGEKRMPEDLDENMDY--------RLMWEVRGSkgevlYILDATnpRHSNWLRFV-HEAPS 90
Cdd:smart00317  12 GWGVRATEDIPKGEFIGEYVGEIITSEEAEERPKAydtdgakaFYLFDIDSD-----LCIDAR--RKGNLARFInHSCEP 84

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1823752927   91 QEQkNLAAIQEGENIFYL-AVEDIETDTELLIGYLDSDMEA 130
Cdd:smart00317  85 NCE-LLFVEVNGDDRIVIfALRDIKPGEELTIDYGSDYANE 124
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 20-123 1.63e-06

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 47.13  E-value: 1.63e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752927  20 GMGLYTARRVRKGEKFGPFAGEKRM-PEDLDENMDYRLMWEVRGSKGEVL--------YILDATNPRHSNWLRFV-HEAP 89
Cdd:pfam00856   1 GRGLFATEDIPKGEFIGEYVEVLLItKEEADKRELLYYDKLELRLWGPYLftldedseYCIDARALYYGNWARFInHSCD 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1823752927  90 SQEQKNLAAIQEGENIFYLAVEDIETDTELLIGY 123
Cdd:pfam00856  81 PNCEVRVVYVNGGPRIVIFALRDIKPGEELTIDY 114
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
298-488 6.43e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.46  E-value: 6.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752927 298 FISANQLKRHMITHSEKR-PYNCEICNKSFKRLDQVGAHK--VIHS--EDKPYKC--KLCGKGFAHRNVYKNHKKTHSEE 370
Cdd:COG5048   270 SQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLrsVNHSgeSLKPFSCpySLCGKLFSRNDALKRHILLHTSI 349

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752927 371 RPFQCeeckaLFRTPFSLQRHLLIHNSERTFkCHHCDATFKRKDTLNVHvqvvherhkkyrceLCNKAFVTPSVLRSHKK 450
Cdd:COG5048   350 SPAKE-----KLLNSSSKFSPLLNNEPPQSL-QQYKDLKNDKKSETLSN--------------SCIRNFKRDSNLSLHII 409

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1823752927 451 THT--GEKEKICPYCGQKFASSGTLRVHIRSHTGERPYQC 488
Cdd:COG5048   410 THLsfRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC 449
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 482-559 9.22e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.09  E-value: 9.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752927 482 GERPYQCPY--CEKGFSKNDGLKMHiRTHTRvCDLAFSLKKMLIRHKMTHNPNRPLaECQFCHKKFTRNDYLKVHMDNIH 559
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYH-MLHGH-QNQKLHENPSPEKMNIFSAKDKPY-RCEVCDKRYKNLNGLKYHRKHSH 422
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 172-224 1.56e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 40.62  E-value: 1.56e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1823752927 172 CESSFTSEDILaehlqTLHQKpteEKEFKCKNCGKKFPVKQALQRHFEQ-HQET 224
Cdd:cd20908     7 CDREFDDEKIL-----IQHQK---AKHFKCHICHKKLYTAGGLAVHCLQvHKET 52
zf-H2C2_2 pfam13465
Zinc-finger double domain;
473-497 4.96e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.96e-04
                          10        20
                  ....*....|....*....|....*
gi 1823752927 473 LRVHIRSHTGERPYQCPYCEKGFSK 497
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 459-512 6.89e-04

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 39.86  E-value: 6.89e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1823752927 459 ICPYCGQKFASSGTLRVHIRshTGERPYQCPYCEKGFSKNDGLKMHIRTHTRVC 512
Cdd:PHA00733   75 VCPLCLMPFSSSVSLKQHIR--YTEHSKVCPVCGKEFRNTDSTLDHVCKKHNIC 126
 
Name Accession Description Interval E-value
PR-SET_PRDM5 cd19190
PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 ...
 2-128 7.71e-98

PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 (also termed PR domain-containing protein 5) is a sequence-specific DNA-binding transcription factor that represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1.


Pssm-ID: 380967  Cd Length: 127  Bit Score: 293.04  E-value: 7.71e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752927   2 LGMYVPDRFSLKSSRVQDGMGLYTARRVRKGEKFGPFAGEKRMPEDLDENMDYRLMWEVRGSKGEVLYILDATNPRHSNW 81
Cdd:cd19190     1 LGMYVPDRFSLKSSKVQDGMGLYTARRVKKGEKFGPFAGEKRMPNELDESMDPRLMWEVRGSKGEVLYILDASNPRHSNW 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1823752927  82 LRFVHEAPSQEQKNLAAIQEGENIFYLAVEDIETDTELLIGYLDSDM 128
Cdd:cd19190    81 LRFVHEAPSQEQKNLAAIQEGENIFYLAVDDIETDTELLIGYLDSDM 127
PR-SET_PRDM2 cd19188
PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 ...
 3-127 5.75e-27

PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 (also termed GATA-3-binding protein G3B, lysine N-methyltransferase 8, MTB-or MTE-binding protein, PR domain-containing protein 2, retinoblastoma protein-interacting zinc finger protein, or zinc finger protein RIZ) is S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. It may function as a DNA-binding transcription factor.


Pssm-ID: 380965  Cd Length: 123  Bit Score: 105.60  E-value: 5.75e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752927   3 GMYVPDRFSLKSSRVQDG-MGLYTARRVRKGEKFGPFAGEKRMPEDLDENmDYrlMWEVRGSKGEvLYILDATNPRHSNW 81
Cdd:cd19188     1 LMGLPEELELKPSAVDKTrIGVWAKKSIPKGRKFGPFVGEKKKRSQVKNN-VY--MWEIYGPKRG-WMCVDASDPTKGNW 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1823752927  82 LRFVHEAPSQEQKNLAAIQEGENIFYLAVEDIETDTELLIGYLDSD 127
Cdd:cd19188    77 LRYVNWARSGEEQNLFPLQINRAIYYKTLKPIAPGEELLCWYNGED 122
PR-SET_PRDM16_PRDM3 cd19200
PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus ...
 6-133 3.03e-25

PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus protein and similar proteins; PRDM16 (also termed PR domain-containing protein 16, transcription factor MEL1, or MDS1/EVI1-like gene 1) functions as a transcriptional regulator. PRDM16 is preferentially expressed by hematopoietic and neuronal stem cells. It is closely related to paralog of PRDM3 (also termed MDS1 and EVI1 complex locus protein, ecotropic virus integration site 1 protein, EVI-1, myelodysplasia syndrome 1 protein, myelodysplasia syndrome-associated protein 1, or MECOM) which is a nuclear transcription factor essential for the proliferation/maintenance of hematopoietic stem cells (HSCs). PRDM3 and PRDM16 are both directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380977  Cd Length: 135  Bit Score: 101.29  E-value: 3.03e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752927   6 VPDRFSLKSSRVQ-DGMGLYTARRVRKGEKFGPFAGEKRmpeDLDENMDYRlmWEVRGSKGEVLYILDATNPRHSNWLRF 84
Cdd:cd19200    10 IPPDFELRESAAVgAGLGVWTKVRIEVGEKFGPFVGVQR---SSVKDPTYA--WEIVDEFGKVKFWIDASEPGTGNWMKY 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1823752927  85 VHEAPSQEQKNLAAIQEGENIFYLAVEDIETDTELLIgYLDSDMEAEEE 133
Cdd:cd19200    85 IRSAPSCEQQNLMACQIDEQIYYKVVRDIQPGEELLL-YMKAAVYPHET 132
PR-SET_PRDM12 cd19196
PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 ...
 6-123 2.04e-24

PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 (also termed PR domain-containing protein 12) acts as a transcription factor that is involved in the positive regulation of histone H3-K9 dimethylation.


Pssm-ID: 380973 [Multi-domain]  Cd Length: 130  Bit Score: 98.58  E-value: 2.04e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752927   6 VPDRFSLKSSRVQ-DGMGLYTARRVRKGEKFGPFAGEKRMPEDLDENMDYRLMWEVRGSKGEVLYILDATNPRHSNWLRF 84
Cdd:cd19196     1 LPSQVIIAQSSIPgAGLGVFSKTWIKEGTEMGPYTGRIVSPEDVDPCKNNNLMWEVFNEDGTVSHFIDASQENHRSWMTF 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1823752927  85 VHEAPSQEQKNLAAIQEGENIFYLAVEDIETDTELLIGY 123
Cdd:cd19196    81 VNCARNEQEQNLEVVQIGESIYYRAIKDIPPDQELLVWY 119
PR-SET_PRDM7_9 cd19193
PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar ...
 6-126 8.70e-23

PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar proteins; PRDM7 (also termed PR domain-containing protein 7) is a primate-specific histone methyltransferase that is the result of a recent gene duplication of PRDM9. It selectively catalyzes the trimethylation of H3 lysine 4 (H3K4me3). PRDM9 (also termed PR domain-containing protein 9) is a histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 (H3K4me3) during meiotic prophase and is essential for proper meiotic progression. It also efficiently mono-, di-, and trimethylates H3K36. Aberrant PRDM9 expression is assciated with with genome instability in cancer.


Pssm-ID: 380970 [Multi-domain]  Cd Length: 129  Bit Score: 93.84  E-value: 8.70e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752927   6 VPDRFSLKSSRVQD-GMGLYTARRVRKGEKFGPFAGEKRMPEDLDENMdYrlMWEVRGSKGEVLYIlDATNPRHSNWLRF 84
Cdd:cd19193     4 LPPGLSIKRSSIPGaGLGVWAEAPIPKGMVFGPYEGEIVEDEEAADSG-Y--SWQIYKGGKLSHYI-DAKDESKSNWMRY 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1823752927  85 VHEAPSQEQKNLAAIQEGENIFYLAVEDIETDTELLIGYLDS 126
Cdd:cd19193    80 VNCARNEEEQNLVAFQYRGKIYYRTCKDIAPGTELLVWYGDE 121
PR-SET_PRDM1 cd19187
PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 ...
 7-123 5.21e-22

PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 (also termed BLIMP-1, beta-interferon gene positive regulatory domain I-binding factor, PR domain-containing protein 1, positive regulatory domain I-binding factor 1, PRDI-BF1, or PRDI-binding factor 1) acts as a transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs.


Pssm-ID: 380964 [Multi-domain]  Cd Length: 128  Bit Score: 91.62  E-value: 5.21e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752927   7 PDRFSLKSSRVQ-DGMGLYTARRVRKGEKFGPFAGEKRMPEDLDENMDYRLMWEVRGSKGEVLYIlDATNPRHSNWLRFV 85
Cdd:cd19187     4 PRNLTLKYSSVGrEVLGVWSSDYIPRGTRFGPLVGEIYTNDPVPKGANRKYFWRIYSNGEFYHYI-DGFDPSKSNWMRYV 82

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1823752927  86 HEAPSQEQKNLAAIQEGENIFYLAVEDIETDTELLIGY 123
Cdd:cd19187    83 NPAHSLQEQNLVACQIGMNIYFYTVKPIPPNQELLVWY 120
PR-SET_PRDM3 cd19214
PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins; PRDM3 (also ...
 6-138 9.50e-22

PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins; PRDM3 (also termed MDS1 and EVI1 complex locus protein, ecotropic virus integration site 1 protein, EVI-1, myelodysplasia syndrome 1 protein, myelodysplasia syndrome-associated protein 1, or MECOM) is a nuclear transcription factor, which is essential for the proliferation/maintenance of hematopoietic stem cells (HSCs). It is closely related to paralog PRDM16, both o fwhich are directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380991  Cd Length: 158  Bit Score: 91.92  E-value: 9.50e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752927   6 VPDRFSLKSSRVQD-GMGLYTARRVRKGEKFGPFAGEKRMPEDldenmDYRLMWEVRGSKGEVLYILDATNPRHSNWLRF 84
Cdd:cd19214    30 IPSEFELRESNIPGtGLGIWTKRKIEVGEKFGPYVGEQRSNLK-----DPSYGWEVLDEFGNVKFCIDASQPDVGSWLKY 104

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1823752927  85 VHEAPSQEQKNLAAIQEGENIFYLAVEDIETDTELLIGyldsdMEAEEEEQQIM 138
Cdd:cd19214   105 IRFAGCYDQHNLVACQINDQIFYRAVADIDPGEELLLF-----MKSEDYSHETM 153
PR-SET_PRDM6 cd19191
PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 ...
 7-126 1.33e-19

PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 (also termed PR domain-containing protein 6) is a putative histone-lysine N-methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. It may specifically methylate 'Lys-20' of histone H4 when associated with other proteins and in vitro.


Pssm-ID: 380968  Cd Length: 128  Bit Score: 84.84  E-value: 1.33e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752927   7 PDRFSL-KSSRVQDGMGLYTARRVRKGEKFGPFAGEKRMPEDLDENM-DYRLMWEVRGSKGEVLYILDATNPRHSNWLRF 84
Cdd:cd19191     2 PDEVCLcTSSIPGLGYGICAAQRIPQGTWIGPFEGVLVSPEKQIGAVrNTQHLWEIYDQEGTLQHFIDGGDPSKSSWMRY 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1823752927  85 VHEAPSQEQKNLAAIQEGENIFYLAVEDIETDTELLIGYLDS 126
Cdd:cd19191    82 IRCARHCGEQNLTVVQYRGCIFYRACRDIPRGTELLVWYDDS 123
PR-SET_PRDM-like cd10534
PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family ...
 6-123 1.16e-18

PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family of proteins is defined based on the conserved N-terminal PR domain, which is closely related to the Su(var)3-9, enhancer of zeste, and trithorax (SET) domains of histone methyltransferases, and is specifically called PR-SET domain. The family consists of 17 members in primates. PRDMs play diverse roles in cell-cycle regulation, differentiation, and meiotic recombination. The family also contains zinc finger protein ZFPM1 and ZFPM2. ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380932  Cd Length: 83  Bit Score: 80.70  E-value: 1.16e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752927   6 VPDRFSL-KSSRVQDGMGLYTARRVRKGEKFGPFAGEKrmpedldenmdyrlmwevrgskgevlyildatnprhsNWLRF 84
Cdd:cd10534     1 LPAGLELvLSSIPEGGLGVFARRTIPAGTRFGPLEGVV-------------------------------------NWMRF 43

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1823752927  85 VHEAPSQEQKNLAAIQEGENIFYLAVEDIETDTELLIGY 123
Cdd:cd10534    44 VRPARNEEEQNLVAYQHGGQIYFRTTRDIPPGEELLVWY 82
PR-SET_PRDM16 cd19213
PR-SET domain found in PR domain zinc finger protein 16 (PRDM16) and similar proteins; PRDM16, ...
 6-128 2.69e-16

PR-SET domain found in PR domain zinc finger protein 16 (PRDM16) and similar proteins; PRDM16, also termed PR domain-containing protein 16, or transcription factor MEL1, or MDS1/EVI1-like gene 1, functions as a transcriptional regulator. PRDM16 is preferentially expressed by hematopoietic and neuronal stem cells and is closely related to paralog of PRDM3, both of which are directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380990  Cd Length: 162  Bit Score: 76.45  E-value: 2.69e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752927   6 VPDRFSLKSSRVQD-GMGLYTARRVRKGEKFGPFAGEKRMP------------EDLDENMDYRLMWEVRGSKGEVLYILD 72
Cdd:cd19213    20 IPSDFELRESSIPGaGLGVWAKRKIEAGERFGPYTGVQRSTlkdtnfgweqilNDVEVSSQEGCITKIVDDLGNEKFCVD 99

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1823752927  73 ATNPRHSNWLRFVHEAPSQEQKNLAAIQEGENIFYLAVEDIETDTELLI-----GYLDSDM 128
Cdd:cd19213   100 AGQAGAGSWLKYIRVACSCDEQNLTACQINEQIYYKVIKDIEPGEELLVyvkdgVYPLGTM 160
PR-SET_PRDM14 cd19198
PR-SET domain found in PR domain zinc finger protein 14 (PRDM14) and similar proteins; PRDM14 ...
 22-125 8.11e-15

PR-SET domain found in PR domain zinc finger protein 14 (PRDM14) and similar proteins; PRDM14 (also termed PR domain-containing protein 14) acts as a transcription factor that has both positive and negative roles on transcription. It acts on regulating epigenetic modifications in the cells, playing a key role in the regulation of cell pluripotency, epigenetic reprogramming, differentiation and development. Aberrant PRDM14 expression is associated with tumorigenesis, cell migration and cell chemotherapeutic drugs resistance.


Pssm-ID: 380975  Cd Length: 133  Bit Score: 71.28  E-value: 8.11e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752927  22 GLYTARRVRKGEKFGPFAGEKRMPEDLDENMDYRLMWEVRgSKGEVLYILDAtNPRHSNWLRFVHEAPSQEQKNLAAIQE 101
Cdd:cd19198    21 GVFCKKTIPKGTRFGPFRGRVVNTSEIKTYDDNSFMWEIF-EDGKLSHFIDG-RGSTGNWMSYVNCARYAEEQNLIAIQC 98

                          90       100
                  ....*....|....*....|....
gi 1823752927 102 GENIFYLAVEDIETDTELLIGYLD 125
Cdd:cd19198    99 QGQIFYESCKEILQGQELLVWYGD 122
PR-SET_ZFPM cd19201
PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also ...
 22-127 1.00e-14

PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380978  Cd Length: 122  Bit Score: 70.84  E-value: 1.00e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752927  22 GLYTARRVRKGEKFGPFAGekRMpEDLDENMDYRLMWEVRGSKGEVLYILDATNPrhSNWLRFVHEAPSQEQKNLAAIQE 101
Cdd:cd19201    21 GVWAKQPLPEGTRFGPYPG--KL-VKEPLDPSYEWKVEAQGSKGGEGLLLLTEDS--GTWLKLVRSADDEDEANLILYFK 95

                          90       100
                  ....*....|....*....|....*.
gi 1823752927 102 GENIFYLAVEDIETDTELLIGYLDSD 127
Cdd:cd19201    96 GGQIWCEVTKDIPPGEELILVLREPL 121
PR-SET_PRDM4 cd19189
PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 ...
 4-123 6.48e-13

PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 (also termed PR domain-containing protein 4, or PFM1) may function as a transcription factor involved in cell differentiation.


Pssm-ID: 380966  Cd Length: 133  Bit Score: 65.95  E-value: 6.48e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752927   4 MYVPDRFSLKSSRVQDGMGLYTARRVRKGEKFGPFAGEKRMPEDLDENMDYRL--MWEVRgSKGEVLYILDATNPRHSNW 81
Cdd:cd19189     4 LSLPRQLYLRQSETGAEVGVWTKETIPVRTCFGPLIGQQSHSAEVADWTDKAAphIWKIY-HNDVLEFCIITTDENECNW 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1823752927  82 LRFVHEAPSQEQKNLAAIQEGENIFYLAVEDIETDTELLIGY 123
Cdd:cd19189    83 MMFVRKARTREEQNLVAYPHDGKIYFCTSRDIPPDQELLFYY 124
PR-SET_PRDM10 cd19194
PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 ...
 22-123 7.97e-13

PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 (also termed PR domain-containing protein 10, or tristanin) may be involved in transcriptional regulation.


Pssm-ID: 380971  Cd Length: 128  Bit Score: 65.45  E-value: 7.97e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752927  22 GLYTARRVRKGEKFGPFAGEkrMPEDLDENMDYRLMWEVRGSKGEVLYIlDATNPRHSNWLRFVHEAPSQEQKNLAAIQE 101
Cdd:cd19194    21 GVFAKRRIPKRTQFGPLEGP--LVKKSELKDNKIHPLELEEDDGEDLYF-DLSDENKCNWMMFVRPAQNHLEQNLVAYQY 97

                          90       100
                  ....*....|....*....|..
gi 1823752927 102 GENIFYLAVEDIETDTELLIGY 123
Cdd:cd19194    98 GQEIYFTTIKNIEPKQELKVWY 119
PR-SET_PRDM15 cd19199
PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 ...
 11-123 6.60e-09

PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 (also termed PR domain-containing protein 15, or zinc finger protein 298 (ZNF298)) may be involved in transcriptional regulation. It plays an essential role as a chromatin factor that modulates the transcription of upstream regulators of WNT and MAPK-ERK signaling to safeguard naive pluripotency.


Pssm-ID: 380976  Cd Length: 126  Bit Score: 54.34  E-value: 6.60e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752927  11 SLKSSRVQDGM-GLYTARRVRKGEKFGPFAGEK--RMPEdldENMDYRLMWEVRGSkgevLYILDATNPRHSNWLRFVHE 87
Cdd:cd19199    10 NLEIRQLEDGSeGVFALVPLVKRTQFGPFEAKRvaRLDG---FAVFPLKVFEKDGS----VVYLDTSNEDDCNWMMFVRP 82

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1823752927  88 APSQEQKNLAAIQEGENIFYLAVEDIETDTELLIGY 123
Cdd:cd19199    83 ATDVEHQNLTAYQQGEDIYFTTSRDIQPGAELRVWY 118
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
145-337 8.65e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.70  E-value: 8.65e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752927 145 EVENSRRQSTAGRKDRLGCKEDYACPQCESSFTSEDILAEHLQTLHQKPTEEKEFKC--KNCGKKFPVKQALQRHFEQHq 222
Cdd:COG5048   268 ASSQSSSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSVNHSGESLKPFSCpySLCGKLFSRNDALKRHILLH- 346

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752927 223 etcRGDARFVCKADSCGKRLKSKDALKRHQ--ENVHTGDPKKKLICSV--CNKKCSSASSLQEHRKIH-----EIFDCQE 293
Cdd:COG5048   347 ---TSISPAKEKLLNSSSKFSPLLNNEPPQslQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHlsfrpYNCKNPP 423

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1823752927 294 CMKKFISANQLKRHMITHSEKRPYNCEICNKSFKRLDQVGAHKV 337
Cdd:COG5048   424 CSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 20-130 1.77e-07

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 50.03  E-value: 1.77e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752927   20 GMGLYTARRVRKGEKFGPFAGEKRMPEDLDENMDY--------RLMWEVRGSkgevlYILDATnpRHSNWLRFV-HEAPS 90
Cdd:smart00317  12 GWGVRATEDIPKGEFIGEYVGEIITSEEAEERPKAydtdgakaFYLFDIDSD-----LCIDAR--RKGNLARFInHSCEP 84

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1823752927   91 QEQkNLAAIQEGENIFYL-AVEDIETDTELLIGYLDSDMEA 130
Cdd:smart00317  85 NCE-LLFVEVNGDDRIVIfALRDIKPGEELTIDYGSDYANE 124
PR-SET_PRDM13 cd19197
PR-SET domain found in PR domain zinc finger protein 13 (PRDM13) and similar proteins; PRDM13 ...
 32-123 3.74e-07

PR-SET domain found in PR domain zinc finger protein 13 (PRDM13) and similar proteins; PRDM13 (also termed PR domain-containing protein 13) may be involved in transcriptional regulation. It mediates the balance of inhibitory and excitatory neurons in somatosensory circuits.


Pssm-ID: 380974  Cd Length: 103  Bit Score: 48.66  E-value: 3.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752927  32 GEKFGPFAGEKRMPEDLDENMDYRLMWEVRGSKGEvlYILDATNPRHSNWLRFVHEAPSQEQKNLAAIQE--GENIFYLA 109
Cdd:cd19197     4 GLRLGPVPGIFKLGKYLSDRKEPGNKKKVRRVRGD--YLVDESGSPATEWIGLVRAARNNQEQNLEAIADlpGGQIFYRA 81

                          90
                  ....*....|....
gi 1823752927 110 VEDIETDTELLIGY 123
Cdd:cd19197    82 LRDIQPGEELTVWY 95
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
166-392 6.14e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.01  E-value: 6.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752927 166 DYACPQCESSFTSEDILAEHLQTLHQKPTEEKE------FKCKNCGKKFPVKQALQRHFEQHQETCRGDARFVCKADSCG 239
Cdd:COG5048   251 SDSSSSASESPRSSLPTASSQSSSPNESDSSSEkgfslpIKSKQCNISFSRSSPLTRHLRSVNHSGESLKPFSCPYSLCG 330

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752927 240 KRLKSKDALKRHqENVHTGDPKKKLICSVCNKKCSSAS------SLQEHRKIHEI--FDC--QECMKKFISANQLKRHMI 309
Cdd:COG5048   331 KLFSRNDALKRH-ILLHTSISPAKEKLLNSSSKFSPLLnneppqSLQQYKDLKNDkkSETlsNSCIRNFKRDSNLSLHII 409

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752927 310 THSEKRPYNCeicnksfkrldqvgahkvihsedkpyKCKLCGKGFAHRNVYKNHKKTHSEERPFQCEECKALFRTpFSLQ 389
Cdd:COG5048   410 THLSFRPYNC--------------------------KNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRD-LDLS 462


                  ...
gi 1823752927 390 RHL 392
Cdd:COG5048   463 NHG 465
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 20-123 1.63e-06

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 47.13  E-value: 1.63e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752927  20 GMGLYTARRVRKGEKFGPFAGEKRM-PEDLDENMDYRLMWEVRGSKGEVL--------YILDATNPRHSNWLRFV-HEAP 89
Cdd:pfam00856   1 GRGLFATEDIPKGEFIGEYVEVLLItKEEADKRELLYYDKLELRLWGPYLftldedseYCIDARALYYGNWARFInHSCD 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1823752927  90 SQEQKNLAAIQEGENIFYLAVEDIETDTELLIGY 123
Cdd:pfam00856  81 PNCEVRVVYVNGGPRIVIFALRDIKPGEELTIDY 114
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
169-555 2.25e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.46  E-value: 2.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752927 169 CPQCESSFTSEDILAEHLQTLHQKPTEEKEFKCKNCGKKFPVKQALQRHFEQHQetcrGDARFVCKADSCGKRLKSKDAL 248
Cdd:COG5048     4 TSSQSSSSNNSVLSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHT----GEKPSQCSYSGCDKSFSRPLEL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752927 249 KRHQENVHTG--DPKKKLICSVCNKKCSSASSLQ-EHRKIHEifDCQECMKKFISANQLKRHMITHSEKRPYNCEICNKS 325
Cdd:COG5048    80 SRHLRTHHNNpsDLNSKSLPLSNSKASSSSLSSSsSNSNDNN--LLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSS 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752927 326 FKRLDQ----VGAHKVIHSEDKPYKCKLCG----KGFAHRNVYKNHKKTHSEERPFQCEECKaLFRTPFSLQRHLLIHNS 397
Cdd:COG5048   158 SVNTPQsnslHPPLPANSLSKDPSSNLSLLissnVSTSIPSSSENSPLSSSYSIPSSSSDQN-LENSSSSLPLTTNSQLS 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752927 398 ERTFKCH-----HCDATFKRKDTLNVHVQ--VVHERH--------------KKYRCELCNKAFVTPSVLRSHKKT--HTG 454
Cdd:COG5048   237 PKSLLSQspsslSSSDSSSSASESPRSSLptASSQSSspnesdsssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSG 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752927 455 E--KEKICPY--CGQKFASSGTLRVHIRSHTGERPYQCPYCEKGFSKNDGLKM-----------HIRTHTRVCDLAFSLK 519
Cdd:COG5048   317 EslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqslqqykdLKNDKKSETLSNSCIR 396

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 1823752927 520 KM-----LIRHKMTHNPNRPLA-ECQFCHKKFTRNDYLKVHM 555
Cdd:COG5048   397 NFkrdsnLSLHIITHLSFRPYNcKNPPCSKSFNRHYNLIPHK 438
PR-SET_PRDM11 cd19195
PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 ...
 29-129 6.59e-06

PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 (also termed PR domain-containing protein 11) may be involved in transcription regulation.


Pssm-ID: 380972  Cd Length: 127  Bit Score: 45.62  E-value: 6.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752927  29 VRKGEKFGPFAGEKrMPED----------LDENMDYRLmwevrgskgevlyiLDATNPRHSNWLRFVHEAPSQEQKNLAA 98
Cdd:cd19195    28 IPKGHIFGPYEGQI-CTQDkssgffswliVDKNNRYKS--------------IDGSDETKANWMRYVVISREEREQNLLA 92

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1823752927  99 IQEGENIFYLAVEDIETDTELLIGYLDSDME 129
Cdd:cd19195    93 FQHSEQIYFRACRDIRPGEKLRVWYSEDYMK 123
PR-SET_PRDM17 cd10520
PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 ...
 6-121 6.76e-06

PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 (also termed zinc finger protein 408 (ZNF408)) may be involved in transcriptional regulation.


Pssm-ID: 380918  Cd Length: 121  Bit Score: 45.49  E-value: 6.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752927   6 VPDRFSLKSSRVQD-GMGLY-TARRVRKGEKFGPFAGEKrMPEDLDENMDYRLmwEVRGSKGEVLYILDAtnprhSNWLR 83
Cdd:cd10520     5 LPPGLALGPSLAQEeRLGVWcVGDALQKGTFLGPLEEEL-ESHDLTEGGSPRQ--EESGQSGDVLACEQS-----SKWMR 76

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1823752927  84 FVHEAPSQEQKNLAAIQEGENIFYLAVEDIETDTELLI 121
Cdd:cd10520    77 FACRARSEEESNVAVVRLSGRLHLRVCKDIEPGSELLL 114
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
235-421 9.35e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.15  E-value: 9.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752927 235 ADSCGKRLKSKDALKRHQENVH----TGDPKKKLICSVCNKKCSSASSLQEHR--KIHEI-----FDC--QECMKKFISA 301
Cdd:COG5048   257 ASESPRSSLPTASSQSSSPNESdsssEKGFSLPIKSKQCNISFSRSSPLTRHLrsVNHSGeslkpFSCpySLCGKLFSRN 336

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752927 302 NQLKRHMITHSEKRPYNC--EICNKSFKRLD-----QVGAHKVIHSEDKPYKC--KLCGKGFAHRNVYKNHKKTHSEERP 372
Cdd:COG5048   337 DALKRHILLHTSISPAKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRP 416

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1823752927 373 FQCE--ECKALFRTPFSLQRHLLIHNSERTFKCHHCDATFKRKDTLNVHVQ 421
Cdd:COG5048   417 YNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
298-488 6.43e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.46  E-value: 6.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752927 298 FISANQLKRHMITHSEKR-PYNCEICNKSFKRLDQVGAHK--VIHS--EDKPYKC--KLCGKGFAHRNVYKNHKKTHSEE 370
Cdd:COG5048   270 SQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLrsVNHSgeSLKPFSCpySLCGKLFSRNDALKRHILLHTSI 349

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752927 371 RPFQCeeckaLFRTPFSLQRHLLIHNSERTFkCHHCDATFKRKDTLNVHvqvvherhkkyrceLCNKAFVTPSVLRSHKK 450
Cdd:COG5048   350 SPAKE-----KLLNSSSKFSPLLNNEPPQSL-QQYKDLKNDKKSETLSN--------------SCIRNFKRDSNLSLHII 409

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1823752927 451 THT--GEKEKICPYCGQKFASSGTLRVHIRSHTGERPYQC 488
Cdd:COG5048   410 THLsfRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC 449
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 482-559 9.22e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.09  E-value: 9.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752927 482 GERPYQCPY--CEKGFSKNDGLKMHiRTHTRvCDLAFSLKKMLIRHKMTHNPNRPLaECQFCHKKFTRNDYLKVHMDNIH 559
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYH-MLHGH-QNQKLHENPSPEKMNIFSAKDKPY-RCEVCDKRYKNLNGLKYHRKHSH 422
PR-SET_PRDM8 cd19192
PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins; PRDM8 ...
 22-125 9.39e-05

PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins; PRDM8 (also termed PR domain-containing protein 8) may function as histone methyltransferase, preferentially acting on 'Lys-9' of histone H3.


Pssm-ID: 380969  Cd Length: 131  Bit Score: 42.42  E-value: 9.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752927  22 GLYTARRVRKGEKFGPFAGEKRMPEDLDENMDYRLMWEVRGSKGEVLYILDATNPRHSNWLRFVHEAPSQEQKNLAAIQE 101
Cdd:cd19192    21 SVVTTTDIPAGTIFGPCVLSFTLGYDIADIALKTTDKRVVPYIFRVDTGACNGSSEPSDWLRLVQPARDRHEQNLEAFRK 100

                          90       100
                  ....*....|....*....|....*
gi 1823752927 102 GEN-IFYLAVEDIETDTELLIGYLD 125
Cdd:cd19192   101 NEGqVYFRTLRRIRKGEELLVWYSD 125
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 428-509 1.19e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 1.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752927 428 KKYRCEL--CNKAFVTPSVLRSHKKTHtgekekicpYCGQKFASSGTLRVHIRSHTGERPYQCPYCEKGFSKNDGLKMHi 505
Cdd:COG5189   348 KPYKCPVegCNKKYKNQNGLKYHMLHG---------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH- 417


                  ....
gi 1823752927 506 RTHT 509
Cdd:COG5189   418 RKHS 421
SET_LegAS4-like cd10522
SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and ...
 9-123 1.22e-04

SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and similar proteins; LegAS4 is a type IV secretion system effector of Legionella pneumophila. It contains a SET domain that is involved in the modification of Lys4 of histone H3 (H3K4) in the nucleolus of the host cell, thereby enhancing heterochromatic rDNA transcription. It also contains an ankyrin repeat domain of unknown function at its C-terminal region.


Pssm-ID: 380920 [Multi-domain]  Cd Length: 122  Bit Score: 41.94  E-value: 1.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752927   9 RFSLKSSRVQDGMGLYTARRVRKGEKFGPFAGEKRMPEDLDENMDYRLMWevrgskgevLYILDATNP-------RHSNW 81
Cdd:cd10522     3 DISMIPNLSHNGLGLFAAETIAKGEFVGEYTGEVLDRWEEDRDSVYHYDP---------LYPFDLNGDilvidagKKGNL 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1823752927  82 LRFVHEAPsqeQKNLAAIQ---EGEN-IFYLAVEDIETDTELLIGY 123
Cdd:cd10522    74 TRFINHSD---QPNLELIVrtlKGEQhIGFVAIRDIKPGEELFISY 116
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 172-224 1.56e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 40.62  E-value: 1.56e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1823752927 172 CESSFTSEDILaehlqTLHQKpteEKEFKCKNCGKKFPVKQALQRHFEQ-HQET 224
Cdd:cd20908     7 CDREFDDEKIL-----IQHQK---AKHFKCHICHKKLYTAGGLAVHCLQvHKET 52
zf-H2C2_2 pfam13465
Zinc-finger double domain;
473-497 4.96e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.96e-04
                          10        20
                  ....*....|....*....|....*
gi 1823752927 473 LRVHIRSHTGERPYQCPYCEKGFSK 497
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 459-512 6.89e-04

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 39.86  E-value: 6.89e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1823752927 459 ICPYCGQKFASSGTLRVHIRshTGERPYQCPYCEKGFSKNDGLKMHIRTHTRVC 512
Cdd:PHA00733   75 VCPLCLMPFSSSVSLKQHIR--YTEHSKVCPVCGKEFRNTDSTLDHVCKKHNIC 126
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 294-368 9.82e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 9.82e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1823752927 294 CMKKFISANQLKRHMItHSEKRPYNCEICNKSfkrldqvgAHKVIHSEDKPYKCKLCGKGFAHRNVYKNHKKtHS 368
Cdd:COG5189   357 CNKKYKNQNGLKYHML-HGHQNQKLHENPSPE--------KMNIFSAKDKPYRCEVCDKRYKNLNGLKYHRK-HS 421
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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