|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
20-388 |
0e+00 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 563.88 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 20 AGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKILRKW 99
Cdd:cd17343 40 LGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGLTTVAFSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRKW 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 100 FEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIHNEPADVGLRNLDPAPSKGK- 178
Cdd:cd17343 120 FSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGWRSTLSISGTVAVVMSVVCLLFIKNEPSDVGLNNIEEEESKGKk 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 179 KGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRA 258
Cdd:cd17343 200 KKSPRGESTLKELLLSPFLWLLSLGYLVVFGVKTAVTDWGQLFLIQDKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWA 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 259 MAKAGLSLYGNPRHGLLLLMMAGMAASMFLFRVTVTSDSPKIWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHA 338
Cdd:cd17343 280 VAKHGSSSRGNPRMPLALVFMAGLTVSLHLFRVHITSDSSELFILLLGFLIGFSLYGPIAIFGVIANESAPSHLCGTSHA 359
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1820395190 339 IVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFFLLRNI 388
Cdd:cd17343 360 IVALAANVGGVLAGLPFSYIAKHYDWRTAFLLLEILCAITVVILFLLRNI 409
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
21-368 |
3.30e-117 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 345.90 E-value: 3.30e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 21 GLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKILRKWF 100
Cdd:TIGR00881 33 GLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWF 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 101 EPSQFGTWWAVLSTSMNLAGSLGP-ILATILAQSYSWRSTLALSGALCVVVSFFCLLLIHNEPADVGLRNLDPAPS---- 175
Cdd:TIGR00881 113 SRSERGTWVSFWNCSHNVGGGLLPpLVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLLRDSPQSCGLPPAEEMPNeepd 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 176 ----KGKKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAA 251
Cdd:TIGR00881 193 gdaeKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLA 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 252 GYLSDRamakaglsLYGNPRHGLLLLMMAGMAASMFLFRVTVTSDSPkiWILVLGAVFGFSSYGPIALFGVIANESAPPN 331
Cdd:TIGR00881 273 GWLSDK--------LFNGRRGPLAVFFMALIIVSLLVYWLNPAANPL--MDLICLFALGFLVYGPQMLIGVIASELAPKK 342
|
330 340 350
....*....|....*....|....*....|....*..
gi 1820395190 332 LCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAF 368
Cdd:TIGR00881 343 AAGTAAGFVGFFAYLGGILAGLPLGYLADGFGWAGAF 379
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
21-386 |
1.65e-90 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 277.23 E-value: 1.65e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 21 GLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKILRKWF 100
Cdd:cd17312 41 GIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWF 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 101 EPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIHNEPadvglrnldpapskgkkg 180
Cdd:cd17312 121 SKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRDSP------------------ 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 181 sskeestlqdlllsPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRama 260
Cdd:cd17312 183 --------------PYVWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDK--- 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 261 kaglsLYGNPRHGLLLLMMAGMAASMFLFRVTVtsdSPKIWILVLGAVFGFSSYGPIALFGVIANESAPP-NLCGTSHAI 339
Cdd:cd17312 246 -----LFGGRRAPIAVIYMLLMTLSLALFWFFP---HNKLLSIVLLFLIGFFVGGPINLIGGAAAQDIGRkEAAGTATGF 317
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1820395190 340 VGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFFLLR 386
Cdd:cd17312 318 VGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISAALLSVLLLLSLW 364
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
31-384 |
3.72e-55 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 188.00 E-value: 3.72e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 31 YAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKILRKWFEPSQFGTWWA 110
Cdd:PRK11663 71 YGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFSSSLWAFALLWVLNAFFQGWGWPVCAKLLTAWYSRTERGGWWA 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 111 VLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIHNEPADVGL------RN--LDPAPSKGKKGSS 182
Cdd:PRK11663 151 IWNTAHNVGGALIPLVVGAIALHYGWRYGMMIAGIIAIVVGLFLCWRLRDKPQAMGLpsvgewRHdaLELAQQQEGAGLS 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 183 KEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRamaka 262
Cdd:PRK11663 231 RKEILTKYVLLNPYIWLLSFSYVLVYVVRAAINDWGNLYMSETLGVDLVTANSAVSMFELGGFIGALVAGWGSDK----- 305
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 263 glsLYGNPRHGLLLLMMAGMaasmfLFRVTVTSDSPKIWILVLGAVF---GFSSYGPIALFGVIANESAPPNLCGTSHAI 339
Cdd:PRK11663 306 ---LFNGNRGPMNLIFAAGI-----LLSVGSLWLMPFASYVMQAACFftiGFFVFGPQMLIGMAAAECSHKEAAGAATGF 377
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1820395190 340 VGLMANVGGFLAGLPFSTIAKHYSWsTAFWVAEVVCGASTVVFFL 384
Cdd:PRK11663 378 VGLFAYLGAALSGYPLAKVLEIWHW-TGFFVVISIAAGISALLLL 421
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
21-385 |
2.42e-48 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 167.97 E-value: 2.42e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 21 GLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKILRKWF 100
Cdd:cd17488 41 GILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIINILFGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWY 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 101 EPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIHNEPadvglrnldpapskgkkg 180
Cdd:cd17488 121 SRNERGFWWSIWNTSHNIGGALIPILTGFAALTYGWRAGMYVPGIIAILMGIVLCWRLRDRP------------------ 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 181 sskeestlqdlllsPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRama 260
Cdd:cd17488 183 --------------PYIWLLAFCYVLVYVVRTAINDWGNLYLSETHGYSLVKANSAVSLFEVGGLIGALVAGWGSDK--- 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 261 kaglsLYGNPRHGLLLLMMAGMAASMFLfrVTVTSDSPKIWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIV 340
Cdd:cd17488 246 -----LFKGNRGPMNLIFALGLLVSVGA--LWLVPVHSYWLLATCFFTIGFFVFGPQMLIGMAAAECSHKDAAGSATGFV 318
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1820395190 341 GLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFFLL 385
Cdd:cd17488 319 GLFAYLGAALAGYPLAKVIESWGWSGFFIVISIAAAISGLLLLPL 363
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
21-386 |
2.37e-45 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 161.26 E-value: 2.37e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 21 GLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVF----SWSSTVSAFAALWFLNGLAQGLGWPPCGKIL 96
Cdd:cd17345 41 GLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIgfvpSATSSVGLMFILLFLNGWFQGMGWPPSGRTM 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 97 RKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQ---SYSWRSTLALSGALCVVVSFFCLLLIHNEPADVGLRNL--- 170
Cdd:cd17345 121 VHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAifgDGWWRGAFIFPAIIAIIVAVIVLFLGKDTPESEGLPPIeey 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 171 --DPAPSKGKKGSSKEESTLQDL----LLSPYLWVLSTG----YLVVFGVktccTDWGQFFLIQERGQSALVGSSYISAL 240
Cdd:cd17345 201 kgDYPEEADGEEEEQELSAWEIFvkyvLKNKLLWYIAIAnvfvYLVRYGI----LDWAPTYLSEVKGFSKAQAMWAFSLF 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 241 EVGGLVGSIAAGYLSDRamakaglsLYGNPRHGLLLLMMAGMAASMFlfrVTVTSDSPkIWILVLGAVFGFSSYGPIALF 320
Cdd:cd17345 277 EWAAIPGTLLAGWLSDK--------LFKGRRAPTGIIFMILVIVALI---VYWLAPNV-LVDLIALIALGFLIYGPVMLI 344
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1820395190 321 GVIANESAPPNLCGTSHAIVGLMANVGG-FLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFFLLR 386
Cdd:cd17345 345 GLQALELVPKKAAGTAAGLTGLFGYLGGsVLATALIGIIVDHFGWNGGFIVLLASCILAIIFLALVA 411
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
17-386 |
2.53e-41 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 149.25 E-value: 2.53e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 17 PFAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKIL 96
Cdd:COG2271 44 AAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLI 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 97 RKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFclllihnepadvglrnldpapsk 176
Cdd:COG2271 124 AEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALL----------------------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 177 gkkgsskeestlqdlllspYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSD 256
Cdd:COG2271 181 -------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSD 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 257 RamakaglslYGNPRHGLLLLMMAGMAASMFLFRVTvtsdSPKIWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTS 336
Cdd:COG2271 242 R---------LGRRRKLVLAIGLLLAALALLLLALL----PSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTA 308
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1820395190 337 HAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFFLLR 386
Cdd:COG2271 309 SGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLL 358
|
|
| glpT |
TIGR00712 |
glycerol-3-phosphate transporter; This model describes a very hydrophobic protein, predicted ... |
21-385 |
8.45e-29 |
|
glycerol-3-phosphate transporter; This model describes a very hydrophobic protein, predicted to span the membrane at least 8 times. The two members confirmed experimentally as glycerol-3-phosphate transporters, from E. coli and B. subtilis, share more than 50 % amino acid identity. Proteins of the hexose phosphate and phosphoglycerate transport systems are also quite similar. [Transport and binding proteins, Other]
Pssm-ID: 129795 [Multi-domain] Cd Length: 438 Bit Score: 116.48 E-value: 8.45e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 21 GLITSSQSAAYAISKFVSGVLSDQMSARWLFSS---GLLLVGLVNVVFSW-SSTVSAFAALWFLNGLAQGLGWPPCGKIL 96
Cdd:TIGR00712 64 GFALSAISIAYGFSKFIMGSVSDRSNPRVFLPAgliLSAAVMLLMGFVPWaTSSIAIMFVLLFLNGWFQGMGWPPCGRTM 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 97 RKWFEPSQFGTWWAVLSTSMNLAGSLGPILATI-LAQSYSWRSTLALSGALCVVVSFFCLLLIHNEPADVGLRNL----- 170
Cdd:TIGR00712 144 VHWWSQSERGTIVSIWNCAHNIGGGIPPLLVLLgMAWFNDWHAALYFPAICAIIVALFAFAMMRDTPQSCGLPPIeeyrn 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 171 ---DPAPSKGKKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGqSALVGSSYISAL-EVGGLV 246
Cdd:TIGR00712 224 dypDDYNEKAEQELTAKEIFMQYVLPNKLLWYIAIANVFVYLLRYGVLDWSPTYLKEVKH-FALDKSSWAYFLyEYAGIP 302
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 247 GSIAAGYLSDRamakaglsLYGNPRHGLLLLMMAGMAASMFLFRVTVTSDSPKIWILVLgaVFGFSSYGPIALFGVIANE 326
Cdd:TIGR00712 303 GTLLCGWMSDK--------VFKGNRGATGVFFMTLVTIAVIVYWMNPAGNPLVDMICMI--VIGFLIYGPVMLIGLHALE 372
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 327 SAPPNLCGTSHAIVGLMANVGGFL-AGLPFSTIAKHYSWSTAFWVaeVVCGASTVVFFLL 385
Cdd:TIGR00712 373 LAPKKAAGTAAGFTGLFGYLGGSVaASAIVGYTVDFFGWDGGFMV--MIGGSILAVILLI 430
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
17-386 |
1.26e-26 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 109.97 E-value: 1.26e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 17 PFAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKIL 96
Cdd:COG2223 39 AAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALV 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 97 RKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIHNEPADVglrnldpapsk 176
Cdd:COG2223 119 SKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGA----------- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 177 gKKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSD 256
Cdd:COG2223 188 -AAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSD 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 257 RAmakaglslygnPRHGLLLLMMAGMAASMFLFrvTVTSDSPKIWILVLGAVFGFSSYGPIALFGVIAnESAPPNLCGTS 336
Cdd:COG2223 267 RI-----------GGRRVLLIVFALMALGLLLL--ALALGSLWLFLVLFLLLGLALGGGNGAVFALVP-DIFPTKNAGAV 332
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1820395190 337 HAIVGLMANVGGFLAGLPFSTIAKHY-SWSTAFWVAEVVCGASTVVFFLLR 386
Cdd:COG2223 333 YGLVGAAGGLGGFLGPLLFGALLDATgSYTAAFLVFAVLALVALVLTLLLY 383
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
17-351 |
2.06e-24 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 102.88 E-value: 2.06e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 17 PFAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKIL 96
Cdd:pfam07690 31 PTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALI 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 97 RKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIHNEPAdvglrnldPAPSK 176
Cdd:pfam07690 111 ADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPES--------KRPKP 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 177 GKKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTdwGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSD 256
Cdd:pfam07690 183 AEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLT--YLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSD 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 257 RAmakaglslygnPRHGLLLLMMAGMAASMFLFrVTVTSDSPKIWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTS 336
Cdd:pfam07690 261 RL-----------GRRRRLLLALLLLILAALGL-LLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTA 328
|
330
....*....|....*
gi 1820395190 337 HAIVGLMANVGGFLA 351
Cdd:pfam07690 329 SGLYNTAGSLGGALG 343
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
17-351 |
3.96e-24 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 101.97 E-value: 3.96e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 17 PFAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKIL 96
Cdd:COG2814 44 PAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALI 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 97 RKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIhnepadvglrnldpaPSK 176
Cdd:COG2814 124 ADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLL---------------PES 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 177 GKKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSD 256
Cdd:COG2814 189 RPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLAD 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 257 RAmakaglslygnPRHGLLLLMMAGMAASMFLFRVTVTSdspkIWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTS 336
Cdd:COG2814 269 RF-----------GRRRLLLIGLLLLALGLLLLALAGSL----WLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRA 333
|
330
....*....|....*
gi 1820395190 337 HAIVGLMANVGGFLA 351
Cdd:COG2814 334 SGLYNSAFFLGGPLA 348
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
15-384 |
2.44e-21 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 94.42 E-value: 2.44e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 15 LLPFAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGK 94
Cdd:cd06174 28 LSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 95 ILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQ--SYSWRSTLALSGALCVVVSFFCLLLIHNEPADVGLRNLDP 172
Cdd:cd06174 108 LIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEA 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 173 APSKGKKGsskeestLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAG 252
Cdd:cd06174 188 SSKSVLKL-------LKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLG 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 253 YLSDRamakaglslyGNPRHGLLLLMMAGMAASMFLFRVTvtsdSPKIWILVLGAVFGFSSYGPIALFGVIANESAPPNL 332
Cdd:cd06174 261 LLSDR----------LIGRKPLLLIGLLLMALGLALLLLA----PSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEI 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1820395190 333 CGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFFL 384
Cdd:cd06174 327 RGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
17-385 |
1.14e-20 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 92.25 E-value: 1.14e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 17 PFAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKIL 96
Cdd:cd17319 37 PTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKAL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 97 RKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIhnePADVGLrnldpapsk 176
Cdd:cd17319 117 AEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYL---RQVWGL--------- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 177 gkkgsskeesTLQDLLLSPYLWVLSTgylvvfgvktcctdWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSD 256
Cdd:cd17319 185 ----------ALGYFGINYALYGLLT--------------WLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSD 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 257 RAMAKAglslygnpRHGLLLLMMAGMAASMFLFrvtVTSDSPKIWILVLGAVFGFsSYGPIALFGVIANESAPPNLCGTS 336
Cdd:cd17319 241 RLLRGA--------RRLVIIIGLLLAAVGLLLA---YLTTSPVVAVILLSLAGFG-IGAASPVFWSLPADLLPGEAAATA 308
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1820395190 337 HAIVGLMANVGGFLAGLPFSTIAKH-YSWSTAFWVAEVVCGASTVVFFLL 385
Cdd:cd17319 309 GGLINSGGNLGGFVAPLLIGYLVDAtGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
21-384 |
3.81e-20 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 91.69 E-value: 3.81e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 21 GLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSW----SSTVSAFAALWFLNGLAQGLGWPPCGKIL 96
Cdd:PRK11273 66 GFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFvpwaTSSIAVMFVLLFLCGWFQGMGWPPCGRTM 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 97 RKWFEPSQFGTWWAVLSTSMNLAGSL-GPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIHNEPADVGL------RN 169
Cdd:PRK11273 146 VHWWSQKERGGIVSVWNCAHNVGGGLpPLLFLLGMAWFNDWHAALYMPAFAAILVALFAFAMMRDTPQSCGLppieeyKN 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 170 LDPA--PSKGKKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLiQERGQSALVGSSYISAL-EVGGLV 246
Cdd:PRK11273 226 DYPDdyNEKHEQELTAKQIFMQYVLPNKLLWYIAIANVFVYLLRYGILDWSPTYL-KEVKHFALDKSSWAYFLyEYAGIP 304
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 247 GSIAAGYLSDRAMAkaglslyGNprhgllllmmAGMAASMFLFRVTVTS--------DSPKIWILVLGAVfGFSSYGPIA 318
Cdd:PRK11273 305 GTLLCGWMSDKVFR-------GN----------RGATGVFFMTLVTIATivywlnpaGNPTVDMACMIVI-GFLIYGPVM 366
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 319 LFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGlpfSTI----AKHYSWSTAFWVAEVVCGASTVVFFL 384
Cdd:PRK11273 367 LIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAA---SAIvgytVDFFGWDGGFMVMIGGSILAVILLIV 433
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
19-382 |
5.88e-19 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 87.68 E-value: 5.88e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 19 AAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKILRK 98
Cdd:cd17475 32 QVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMR 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 99 WFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIHNEpadvglrnldPAPSKGK 178
Cdd:cd17475 112 WFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREP----------PAASAAT 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 179 KGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRa 258
Cdd:cd17475 182 ESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDR- 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 259 makaglsLYGNPRHGLLLLMMAgmAASMFLFRVTVTSDSPKIWILVLG-AVFGFSSYGPIALFGVIANESAPPNLCGTSH 337
Cdd:cd17475 261 -------VFGGRRRPVLVITAA--IAAAALLVLSLLSPGTPLWLLVLLlILLGLFAIGWNGLYLTLVAESAGPEQAGTAL 331
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1820395190 338 AIVGLMANVGGFLAGLPF-STIAKHYSWSTAFWVAEVVCGASTVVF 382
Cdd:cd17475 332 GLANTINFIGIAIGPPLFgLLVDATHSYAPAWLALALLLVLAALLL 377
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
17-386 |
1.81e-17 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 83.01 E-value: 1.81e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 17 PFAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKIL 96
Cdd:cd17325 30 VAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALI 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 97 RKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIHNEPadvglrnldPAPSK 176
Cdd:cd17325 110 ADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPR---------PPPNK 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 177 GKKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSD 256
Cdd:cd17325 181 RAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSD 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 257 RAmakaglslygnPRHGLLLLMMAGMAASMFLFRVtvtsdSPKIWILVLGAVF---GFSSYGPiALFGVIAnESAPPNLC 333
Cdd:cd17325 261 RI-----------GRKPLILIGLLLSAVALLLLPL-----ATSFWLLLLLLALlglGLGLVFP-ATLALLA-DIVPPEGR 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1820395190 334 GTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFFLLR 386
Cdd:cd17325 323 GTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
21-383 |
2.04e-14 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 74.23 E-value: 2.04e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 21 GLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQ--GLGWPPCGKILRK 98
Cdd:cd17355 41 SLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGagTLAAVAFATVAAW 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 99 WFEPSQfGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIHNEPADVGLRNLDPAPSKGk 178
Cdd:cd17355 121 WFERRR-GLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLLLRRRPADLALRAYDDASPAS- 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 179 kgsskEESTLQDLLLSPYLWVLSTGYLVVfGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRa 258
Cdd:cd17355 199 -----PGSTLKEALRSASFWLLALAFFLC-GFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDR- 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 259 makaglslyGNPRHGLLLLMMAGMAASMFLFrvtvTSDSPKIWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHA 338
Cdd:cd17355 272 ---------YSPRRLLAASYALRALGLALLL----LLPFPPLALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFG 338
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1820395190 339 IVGLMANVGGFLAGLPFSTIAKHY-SWSTAFWVAEVVCGASTVVFF 383
Cdd:cd17355 339 LVFAPHQLGSALGPWLGGLLYDRTgSYTAAWALAVALGLIAALLVL 384
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
21-390 |
3.51e-14 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 73.93 E-value: 3.51e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 21 GLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWS-----STVSAFAALWFLNGLAQGLGWPPCGKI 95
Cdd:PRK09556 67 GMIGLGFSITYGVGKTLVGYYADGKNTKQFLPFLLILSAICMLGFGASlgsgsVSLGLMIALWALSGFFQSTGGPCSYST 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 96 LRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLAL---SGALCVVVSFFCLLLIHNEPADVGLRN--- 169
Cdd:PRK09556 147 ITRWTPRRKRGRFLGFWNISHNLGGAGAGGVALWGANYFFDGHVIGMfifPSIIALIIGFIGLRYGSDSPEELGWGKaee 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 170 -LDPAPSKGKKGS-----SKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVG 243
Cdd:PRK09556 227 iFGEPISEEDKETestdmTKWQIFVEYVLKNPVIWLLCFANIFLYIVRIGIDNWSPVYAFQELGFSKEDAINTFTLFEIG 306
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 244 GLVGSIAAGYLSDRAmakaglslygNPRHGLLLLMMAGMAASMFLFRVTVTSDspkiwILVLGAVF--GFSSYGPIALFG 321
Cdd:PRK09556 307 ALVGSLLWGWLSDLA----------NGRRALVACIALALIIFTLGVYQHATSE-----YMYLASLFalGFLVFGPQLLIG 371
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 322 VIANESAPPN--------------LCGTSHAIVGLMANVGGFLAGLPFSTIAKHySWS---TAFWVAEVVCGA--STVVF 382
Cdd:PRK09556 372 VAAVGFVPKKaigvangikgtfayLFGDSFAKVGLGMIADPTKNGTPIFGYTLT-GWAgtfAALDIAAIGCIClmAIVAV 450
|
....*...
gi 1820395190 383 FLLRNIRT 390
Cdd:PRK09556 451 MEERKIRR 458
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
17-385 |
5.42e-14 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 72.98 E-value: 5.42e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 17 PFAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKIL 96
Cdd:COG2807 52 ATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLI 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 97 RKWFePSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIHNEPADvglrnldpapsk 176
Cdd:COG2807 132 KRWF-PDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAA------------ 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 177 gkKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLiQERGQSALVGSSYISALEVGGLVGSIAAGYLSD 256
Cdd:COG2807 199 --AAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPIL-RDAGLSAATAGLLLSLFQLAGIPGSLLVPLLAD 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 257 RAmakaglslygNPRHGLLLLMMAGMAASMFLFrVTVTSDSPKIWILVLGAVFGFSSYGPIALFGVIANESAP-PNLCGT 335
Cdd:COG2807 276 RL----------GDRRPLLLLLGLLGLAGLLGL-LLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEaAALSGM 344
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1820395190 336 SHAIVGLMANVGGFLAGLPFSTIAkhySWSTAFWVAEVVCGASTVVFFLL 385
Cdd:COG2807 345 AQSVGYLLAALGPLLVGALHDATG---SWTAALLLLAALAVLMLVAGLLA 391
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
18-383 |
4.56e-13 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 69.89 E-value: 4.56e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 18 FAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKILR 97
Cdd:cd17478 31 AQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFHPEGARLAS 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 98 KwFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIHnepadvglRNLDPAPSKG 177
Cdd:cd17478 111 Q-AAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRP--------LKKPEAKKAA 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 178 KKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTdwgqfFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDR 257
Cdd:cd17478 182 AKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLP-----FYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDR 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 258 AMAKAglslygnprhgLLLLMMAGMAASMFLFRVTvtsdsPKIWILVLGAVFGFSSYGPIALFGVIANESAPPNLcGTSH 337
Cdd:cd17478 257 FGRRR-----------VIIASLLLAAPFLLLFLLT-----PGIWSYILLVLAGFLLFASFPVTVVLAQELLPGNV-GLAS 319
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1820395190 338 AIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFF 383
Cdd:cd17478 320 GLMMGLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
19-383 |
1.95e-11 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 64.88 E-value: 1.95e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 19 AAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKILRK 98
Cdd:cd17324 35 QAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAAD 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 99 WFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIhnepadvglrnldPAPSKGK 178
Cdd:cd17324 115 LVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLL-------------PSLPPKK 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 179 KGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRA 258
Cdd:cd17324 182 PGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRG 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 259 MAKAglslygnprhglLLLMMAGMAASMFLFrvTVTSDSPKIWILVLgAVFGFSSYGPIALFGVIANESAPPNLcGTSHA 338
Cdd:cd17324 262 GRRA------------LLIALLLLAAALLLL--TLLGPSPLLLLVGL-VLWGLGFFAAHSALQTRVLRLAPEAR-GLASS 325
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1820395190 339 IVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFF 383
Cdd:cd17324 326 LYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
17-385 |
1.17e-09 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 59.55 E-value: 1.17e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 17 PFAAGLITSSQSAAYAISKFVSGVLSDQMSARWL-----FSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPP 91
Cdd:cd06173 33 ALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLliladLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 92 CGKILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSgALCVVVSFFCLLLIHNEPADVGLRNLD 171
Cdd:cd06173 113 RQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAIN-ALSFLLSALLLLFIRRPPPAAPGESSS 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 172 PAPSKGKKGsskeestLQDLLLSPYLWVLSTGYLVVFGVKTCCtdWGQF-FLIQERGQSALVGSSYISALE-VGGLVGSI 249
Cdd:cd06173 192 LLLRDLREG-------LRYLRRSPLLRLLLLALALFALLGGAL--TVLLpLLAKEVLGGGAAGYGLLLAAFgVGALLGAL 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 250 AAGYLSDRamakaglslygNPRHGLLLLMMAGMAASMFLFRVtvtsdSPKIWILVLGAVFGFSSYGPI-ALFGVIANESA 328
Cdd:cd06173 263 LLGRLSKR-----------RRRGRLLLIGALLLGLALLVLGL-----SPSLWLLLAALFLLGLAGGLFnVPLNTLLQLRV 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1820395190 329 PPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFFLL 385
Cdd:cd06173 327 PDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
17-385 |
1.36e-09 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 59.12 E-value: 1.36e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 17 PFAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKIL 96
Cdd:cd17474 33 PAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLI 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 97 RKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAqSYSWRSTLALSGALCVVvSFFCLLLIHNEPadvglrnLDPAPSK 176
Cdd:cd17474 113 GDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLA-AISWRYPFFLLAALIPV-AFLAILFLLPEP-------KEKAKSS 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 177 GKKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTcctdWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSD 256
Cdd:cd17474 184 SATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLT----YLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLK 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 257 RAmakaglslygNPRHGLLLLMMAGMAASMFLFRVTvtsdsPKIWILVLG-AVFGFSSYGPIALFGVIANESAPPNLCGT 335
Cdd:cd17474 260 KR----------FGARRILVIGLLLYALSLLLLGFV-----PSLALLLIAiVLFGLGLGLNLPLLTTLVTELAPEEERGT 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1820395190 336 SHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFFLL 385
Cdd:cd17474 325 ASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
12-391 |
3.21e-09 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 58.33 E-value: 3.21e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 12 SCSLLPFAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPP 91
Cdd:COG0738 37 AFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVA 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 92 CGKILRkWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQ---SYSWRSTLALSGALCVVVSFFCLLLIHnepadvglr 168
Cdd:COG0738 117 ANPYVA-ALGPETAASRLNLLHAFFSLGALLGPLLGGLLILlglSLSWHLPYLILAVLLLLLALLFLRSKL--------- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 169 nldPAPSKGKKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGS 248
Cdd:COG0738 187 ---PEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGR 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 249 IAAGYLSDRAmakaglslygnPRHGLLLLMMAGMAASMFLFRVTVTSDSPKIWILVLGavFGFSSYGPIALfgVIANESA 328
Cdd:COG0738 264 FLGGFLLKRF-----------GPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVG--LGLSLMFPTIF--SLALDGL 328
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1820395190 329 PPNLCGTShAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFFLLRNIRTK 391
Cdd:COG0738 329 GKRTAAAV-SAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRK 390
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
17-383 |
8.46e-08 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 53.78 E-value: 8.46e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 17 PFAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKIL 96
Cdd:cd17328 33 DSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTII 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 97 RKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQS-YSWRSTLALSGALCVVVSFFCLLLIHNEPadvglRNldpAPS 175
Cdd:cd17328 113 ADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQAtGGWRWAFRVTGVLGVLLAILLLLFVREPP-----RG---AAE 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 176 KGKKGSSKEESTLQDL--LLS--PYLWVLSTGYLVVFGVKTCCTDWGQFFLiqeRGQSALVGSSYISALE------VGGL 245
Cdd:cd17328 185 GGVMAKSTATSFLADLkaLAKnpSFILSTLGFTAVSFVTGALAFWAPTFFL---RAFGVGDLSSADVGLIfgaitcIAGV 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 246 VGSIAAGYLSDRAMAKaglslygNPRHGLLLLMMAGMAASMFLFRVTVTSDSPKIWILVLGAV---FGFSSYGPIAlfgV 322
Cdd:cd17328 262 LGVLLGGILADRLRRK-------TPRADPLVCAVGLLAAAPFLFLALVLALSNLLLAWVLLFLgefLLSLNWAPVF---A 331
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1820395190 323 IANESAPPNLCGTSHAIVGLMAN-----VGGFLAGLPFSTIAKHY--------SWSTAFWVAEVVCGASTVVFF 383
Cdd:cd17328 332 ILLYVVIPTRRSTASAIQILLSHllgdaGSPYLIGLISDLLRQNKdsplaeaaSLQYALLLCSFVLVLGGFFFL 405
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
14-353 |
1.49e-07 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 53.13 E-value: 1.49e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 14 SLLPFAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCG 93
Cdd:TIGR00895 48 GLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLN 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 94 KILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCL--------LLIHNEPADV 165
Cdd:TIGR00895 128 ALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMrflpesidFLVSKRPETV 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 166 GLRNLDPAPSKGKKGSSK--EESTLQDLLLSPYLWVLSTGYL---VVFGVKTCCTDWGQFF-------LIQERGQSALVG 233
Cdd:TIGR00895 208 RRIVNAIAPQMQAEAQSAlpEQKSTQGTKRSVFKALFQGKTAritVLLWLLYFMLLVGVYFltnwlpkLMVELGFSLSLA 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 234 SSYISALEVGGLVGSIAAGYLSDRAmakaglslygNPRHGLLLLMMAGmaasMFLFRVTVTSDSPKIwILVLGAVFGFSS 313
Cdd:TIGR00895 288 ATGGALFNFGGVIGSIIFGWLADRL----------GPRVTALLLLLGA----VFAVLVGSTLFSPTL-LLLLGAIAGFFV 352
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1820395190 314 YGPIALFGVIANESAPPNLCGTShaiVGLMANVGGFLAGL 353
Cdd:TIGR00895 353 NGGQSGLYALMALFYPTAIRATG---VGWAIGIGRLGAII 389
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
18-384 |
1.51e-06 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 49.63 E-value: 1.51e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 18 FAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGwPPCGKILR 97
Cdd:cd17333 31 ADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGIL-DTGANTFV 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 98 KWFEPSQFGTWWAVLSTSMNLAGSLGPILAT-ILAQSYSWRSTLALSGALCVVVsfFCLLLIHNEPADVGLRNLDPAPSK 176
Cdd:cd17333 110 GALFEESSATRLNVLHGFFGLGALIGPLIATsLLTSELSWSWAYLIIGLIYLLL--AILILLTLFPELPSARNPQQSVGA 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 177 GKKGSSKEestlqdlLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSD 256
Cdd:cd17333 188 FSASASRL-------LRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISR 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 257 RAMAKAglslygnprhgllLLMMAGMAASMFLFRVTVTSDspKIWILVLGAVFGFSSYGPIALFGVIANESAP-PNLCGT 335
Cdd:cd17333 261 RIKPHT-------------LLVLSGSGALLGLLILLLAPT--LVVGLVATALLGLFMAALFPTILSLGISNLPyAKGKGT 325
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1820395190 336 SHAIVglMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFFL 384
Cdd:cd17333 326 SVLLA--AGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFVLALL 372
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
17-383 |
2.30e-06 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 49.14 E-value: 2.30e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 17 PFAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKIL 96
Cdd:cd17316 35 LLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYV 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 97 RKWFEPSQFGTWWAVLSTSMN----LAGSLGPILATILAQSYSWRSTLALSGALCVVVsffclllihnepadvglrnldp 172
Cdd:cd17316 115 AEFAPSKRRGFALGLLQSGWAlgalLAALVASLLIPLLSGDWGWRILFLIGALPALLA---------------------- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 173 apskgkkgsskeestlqdLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAG 252
Cdd:cd17316 173 ------------------LLLRRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 253 YLSDRAmakaglslygnPRHGLLLLMMAGMAASMFLFrvTVTSDSPKIWILVLGAVFGFSSYGPIALFGVIANESAPPNL 332
Cdd:cd17316 235 LLSDRI-----------GRKKTLVIGLILSGILALPL--FYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEV 301
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1820395190 333 CGTSHAIVGLMAN-VGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFF 383
Cdd:cd17316 302 RATGVGLSYNLGRlGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
220-385 |
1.89e-05 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 46.46 E-value: 1.89e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 220 FFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRamakaglslYGNPRhgLLLLMMAGMAASMFLFRVTVTsdspk 299
Cdd:cd17475 20 PFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDR---------FGERR--VLAVGLLLMGAAALLMALVGS----- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 300 IWILVLGAVFGFSSYGPIALFGVIA-NESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGAS 378
Cdd:cd17475 84 YPVLLVLLFLVGAGYGSVQPGGGRAiMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILA 163
|
....*..
gi 1820395190 379 TVVFFLL 385
Cdd:cd17475 164 AVLFWLF 170
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
32-371 |
2.38e-05 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 46.06 E-value: 2.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 32 AISKFVSGVLSDQMSARW--LFSSGLLLVGLVNVVFSwSSTVSAFAALWFLNGLAQGLGWPPCGKILRKWFePSQFGtww 109
Cdd:cd17353 52 AISAPFAGRLVDRGGPRKaiLIGGILFGLGFILSAFA-ISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWF-PDKRG--- 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 110 avLSTSMNLAG-SLGPI----LATILAQSYSWRSTLALSGALCVVVSFFCLLLIHNEPADVGlrNLDPAPSKGKKGSSKE 184
Cdd:cd17353 127 --LATGIVIAGfGLGSLifspLIAYLINTVGVPTTFLILGIIFLIIIVIGAFLIRDPPKGWV--PPGVDPLANNAENSPR 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 185 ESTLQDLLLSPYLWVLstgYLVVFgvktCCTDWGQF-------FLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDR 257
Cdd:cd17353 203 DYTPREMLRTPTFWLL---WLMFF----LNATAGLMligqakpIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDK 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 258 amakaglslYGnpRHGLLLLMMAGMAASMFLFrvtVTSDSPKIWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSH 337
Cdd:cd17353 276 ---------IG--RKNTLSIAFLIQGVAMFLL---PFIGSVAVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNY 341
|
330 340 350
....*....|....*....|....*....|....
gi 1820395190 338 AIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVA 371
Cdd:cd17353 342 GLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIA 375
|
|
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
29-384 |
2.82e-05 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 45.77 E-value: 2.82e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 29 AAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAF------AALWFLNGLAQGLGWPPCGKILRKWFEP 102
Cdd:cd17342 74 FSYAIGLFISGWLGDRLNLRLVLAFGMCSSAITVFLFGVLTEWLHFynkylyCILWVLNGLLQSTGWPCVVAIMGNWFGK 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 103 SQFGTWWAVLSTSmnlaGSLGPILATILAQS-------YSWRSTLALSGALCVVVsFFCLLlihNEPADVGLRNLDPAPS 175
Cdd:cd17342 154 SSRGFVLGLWSAC----ASVGNIIGALLASSvldygyeYAFLVTSSLLFAGAIVV-FFGLL---SSPPGVIPYSLAYACL 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 176 KgkkgsskeestlqdlllspylwvlSTGYLVVFgvktcctdWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLS 255
Cdd:cd17342 226 K------------------------LVNYSFFF--------WLPFYLSNNFHWKESEADQLSIWYDVGGIIGGIVAGYIS 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 256 DRaMAKaglslygnpRHGLLLLMMAGMAASMFLFRvtvTSDSPKIWILVLGAVFGFSSYGPIALF--GVIANESAPPNLC 333
Cdd:cd17342 274 DR-MGS---------RSPVVVVMLLLAIPSLFVYS---HSPSDKVLNAFVMTITGFFIGGPANLIssAISADLGRQPQLR 340
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1820395190 334 GTSHAivglMANVGGFLAG----------LPFSTIAKHYSWSTAFWVAeVVCGASTVVFFL 384
Cdd:cd17342 341 GSSEA----LATVTGIIDGtgsigaaigqVLVPLIQNRLGWMWVFYFF-IIMTILTIVCIL 396
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
17-386 |
4.89e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 44.89 E-value: 4.89e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 17 PFAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKIL 96
Cdd:cd17489 30 EAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLV 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 97 RKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRStLALSGALCVVVSFFCLLLIHNEPADVGLRNLdpaPSK 176
Cdd:cd17489 110 ADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAV-LFIVAAVLALLALLLVFLVKDPPPVAAEEAE---AGT 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 177 GKKGSSKEESTLQDLLLspyLWVLSTGY------LVVFGVKTCCTDWGQFFLIQergQSALVGSSYISalevgglvgsia 250
Cdd:cd17489 186 RAFRRLVEKKVLPPALI---LFLASIAYgaistfLPLYAAERGISNAGLFFTVY---AIALLLSRPFS------------ 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 251 aGYLSDramakaglslygnpRHGLLLLMMAGM---AASMFLFrvtvtSDSPKIWILVLGAVF---GFSSYGPIalFGVIA 324
Cdd:cd17489 248 -GKLSD--------------RKGPKTVIIPGLlllALGLLLL-----SFAGSPWMLLLAAVLyglGFGLLFPA--LQALA 305
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1820395190 325 NESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFFLLR 386
Cdd:cd17489 306 VDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
110-383 |
5.33e-05 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 44.85 E-value: 5.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 110 AVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLihnepadvglrnldPAPSKGKKGSSKEESTLQ 189
Cdd:cd17471 128 SVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFL--------------LPSVKPPAQKATPASSLV 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 190 DLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSA-LVGS--SYISALEVgglVGSIAAGYLSDRAmakaglsl 266
Cdd:cd17471 194 KAPVNRRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSEsWVGLlfGLAAALEI---PIMLLAGLLAKRF-------- 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 267 ygnprhGLLLLMMAGMAASMFLFRVTVTSDSPkiWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANV 346
Cdd:cd17471 263 ------GKRRLLLAGFLAGVLFYLGLALATSL--WQLIALQLLNAIFIGITAGLGISYFQDLMPGQPGLATTLYSNASRI 334
|
250 260 270
....*....|....*....|....*....|....*..
gi 1820395190 347 GGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFF 383
Cdd:cd17471 335 GSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALVLLL 371
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
19-179 |
8.97e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 44.14 E-value: 8.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 19 AAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKILRK 98
Cdd:cd17329 36 IVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIAD 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 99 WFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSwrSTLALSGALCVVVSFFCLLLIHNEPADVGLRNLDPAPSKGK 178
Cdd:cd17329 116 VTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSF--RLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILRGY 193
|
.
gi 1820395190 179 K 179
Cdd:cd17329 194 K 194
|
|
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
21-319 |
9.78e-05 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 44.23 E-value: 9.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 21 GLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTvSAFAALWF------LNGLAQGLGWPPCGK 94
Cdd:cd17344 65 GALDSAFLFAYAIGMFFSGHIGERLPLRYFLSFGMLLSGLFTALFGLGYY-WNIHSLWYfvvvqiLAGLFQSTGWPSVVA 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 95 ILRKWFEPSQ----FGTWwavlstsmNLAGSLGPILATILAQ---SYSWRSTLALSGALCVVVSFFCLLLIHNEPADVgl 167
Cdd:cd17344 144 CVGNWFGKGKrgliMGIW--------NSHTSVGNILGSLIAGifvSSAWGLSFIVPGIIIAAMGVLVFLFLVEHPPGV-- 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 168 rnldpapskgkkgsskeestlqdlllSPYLWVLSTGYLVVFGVKTcctdWGQFFLIQERGQSALVGSSYISALEVGGLVG 247
Cdd:cd17344 214 --------------------------IEFSLCLFFAKLVSYTFLY----WLPLYISNTAILSAKKAGDLSTLFDVGGIVG 263
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1820395190 248 SIAAGYLSDRAMAKAGLSlygnprhgllLLMMAGMAASMFLFRvTVTSDSPKIWILVLgAVFGFSSYGPIAL 319
Cdd:cd17344 264 GILAGYISDYTGGRATTC----------AAMLILAAPMLFIYN-YFGQVSMTTNIVLL-IVCGLLVNGPYAL 323
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
221-385 |
1.21e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 43.81 E-value: 1.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 221 FLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRAmakaglslygnPRHGLLLLMMAGMAASMFLFrvtVTSDSPkI 300
Cdd:COG2814 35 LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRF-----------GRRRVLLLGLLLFALGSLLC---ALAPSL-W 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 301 WILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTV 380
Cdd:COG2814 100 LLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALL 179
|
....*
gi 1820395190 381 VFFLL 385
Cdd:COG2814 180 LLLRL 184
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
21-158 |
1.52e-04 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 43.38 E-value: 1.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 21 GLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVS--AFAALWFLNGLAQGLGWPPCGKILRK 98
Cdd:cd17318 59 GIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGygALIVLRILQGLAQGVTFPAMHALWAK 138
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1820395190 99 WFEPSQFGtwwaVLSTSMNLAGSLGPI----LATILAQSYSWRSTLALSGALCVVVSFFCLLLI 158
Cdd:cd17318 139 WAPPLERS----RLTSIAYSGSQFGTViampLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLV 198
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
221-385 |
1.83e-04 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 43.44 E-value: 1.83e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 221 FLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRAMAKAGLSLYGnprhgllLLMMAGMAASMFLfrvtvtSDSPKI 300
Cdd:cd17371 235 YLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFA-------LGSAISILLYFFL------PLSPTL 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 301 wILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTShaiVGLMANVGGFLAGL-PFST--IAKHYSWSTAF-WVAEVVCG 376
Cdd:cd17371 302 -ILILGFPLGFFASGPFSGMGAYLTELFPTAVRATA---QGFCYNVGRIIGALfPFLVgfLATSGSLGTAIaVFAAVYYI 377
|
....*....
gi 1820395190 377 ASTVVFFLL 385
Cdd:cd17371 378 AGLVLALLL 386
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
15-385 |
1.83e-04 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 43.39 E-value: 1.83e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 15 LLPFAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWS-STVSAFAALWFLNGLAqGLGWPPCG 93
Cdd:cd17341 31 LSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAvSSYWGLLVLGFLLGFA-GANFASGQ 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 94 KILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQS-------YSWRSTLALSGALCVVVSFFCLLLIHNEPadvg 166
Cdd:cd17341 110 PWASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAGAivfdggfVGWRNAFFVPGILLAIAAVLVLLFGDDLP---- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 167 lrnldpapsKGKKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDW-GQFFliQERGQSALVGSSYISALevGGL 245
Cdd:cd17341 186 ---------TGKASALEFLKVQLAVLKNYRTWILSLLYGVTFGSFVGFSNVlPTYF--KTRFGLPLVTAGILAAL--FPL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 246 VGSI---AAGYLSDRAMAKaglslygnprhGLLLLMMAGMAASMFLFRVTVTSDSPKIWILVLGAVFGFSSYGPI--ALF 320
Cdd:cd17341 253 AGALarpAGGWLSDRFGGR-----------RRLWWLFIVMTIGAALLSLSLPTSGTNLVLFLALFVALGLGAGAGngSVF 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1820395190 321 GVIANESapPNLCGTSHAIVGLMANVGGFLAGLPFSTIAK-HYSWSTAFWvaevVCGASTVVFFLL 385
Cdd:cd17341 322 RMVPFIF--RRELGAVTGLVGAIGGLGGFFLPLLFGSSALmTGSGVGAFS----LFGVLAVACTLL 381
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
17-168 |
2.40e-04 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 42.49 E-value: 2.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 17 PFAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKIL 96
Cdd:COG0477 48 SAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALI 127
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1820395190 97 RKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIHNEPADVGLR 168
Cdd:COG0477 128 AELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALL 199
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
18-386 |
3.45e-04 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 42.54 E-value: 3.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 18 FAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAF-AALWFLNGLAQGLGWPPCGKIL 96
Cdd:cd17352 38 SDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLyLTYGVLGGLGLGLIYSPAIVIV 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 97 RKWFEPsqfgtwWAVLSTSMNLAGS-LG----PILATILAQSYSWRSTLALSGALCVVVSFFCLLLIhnepadvglrnld 171
Cdd:cd17352 118 GQYFEK------KRGLATGIAVAGSgVGtfvfPPLLRYLLDNYGWRGALLILGGLCLNLCVCGLLLR------------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 172 papskgkkgsskeestlqdLLLSP-YLWVLSTGYLVVFGVKTCCTdwGQFFLIQERGQSALVGSSYISALEVGGLVGSIA 250
Cdd:cd17352 179 -------------------LLKDPtFVLLALGVSFAMLGFFVPFV--YLPSYAKSLGIDESDAAFLLSIIGISDIVGRIL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 251 AGYLSDRamakaglSLYGNPRHGLLLLMMAGMAASMFLFRVTVTSdspkiwILVLGAVFGFSSYGPIALFGVIANESAPP 330
Cdd:cd17352 238 LGLLADK-------PRIGRLYLYIFTLLILGLSLLAFPLATTYVG------LIVFSVLFGFCSGSYSSLTPVILADLVGL 304
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1820395190 331 NLCGTSHAIVGLMANVGGfLAGLPFS--TIAKHYSWSTAFWVAEVVCGASTVVFFLLR 386
Cdd:cd17352 305 EKLSNAYGLVLLFQGLAA-LVGPPIAglLRDYTGDYDAAFYFCGACLLLSGVLLFLLP 361
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
95-348 |
4.43e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 42.16 E-value: 4.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 95 ILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVsffclllihnepadvglrnldpap 174
Cdd:cd17321 108 LIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVA------------------------ 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 175 skgkkgsskeestlqdLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYL 254
Cdd:cd17321 164 ----------------LLLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRL 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 255 SDRAMAKAglslygnprhgLLLLMMAGMAASMFLFRVTVTSDSPKIWILVLgAVFGFSSYGPIALFGVIANESAPPNLCG 334
Cdd:cd17321 228 ADRFGPRL-----------VLVAGLLLTAVGLLLLALLGADSSVWLLLPGL-VLLGLGLGLFATPLTNAALSSVPKEKAG 295
|
250
....*....|....
gi 1820395190 335 TSHAIVGLMANVGG 348
Cdd:cd17321 296 AASGILNTARQLGG 309
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
112-398 |
6.84e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 41.43 E-value: 6.84e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 112 LSTSMNLAGSLGPILATILA----------QSYSWRSTLALSGALCVVVSFFCLLLIHnepadvglrnlDPAPSKGKKGS 181
Cdd:COG2211 148 LSSWRFAFAGLGGLLASVLPpplvaafggdAALGYRLTALIFAVLGLLAFLLTFFGTK-----------ERPVPEEEKVS 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 182 SKEesTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRamak 261
Cdd:COG2211 217 LKE--SLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKR---- 290
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 262 aglslYGnpRHGLLLLMMAGMAASMFLFRVTVTSDSPkiWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSH---- 337
Cdd:COG2211 291 -----FG--KKKAFIIGLLLAALGLLLLFFLGPGNLW--LLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTGRrreg 361
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1820395190 338 ------------------AIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFFLLRNIRTKMGRVSKK 398
Cdd:COG2211 362 lyfgiftfaiklgqalagALAGLLLALFGYVAGAAQSPSALTGIRLLFFLLPAVLLLLAALLLLFYPLTRERHAEIRAE 440
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
221-400 |
1.27e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 40.48 E-value: 1.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 221 FLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRamakaglslYGNPRhgLLLLMMAGMAASMFLFRVTVTSdspkI 300
Cdd:pfam07690 22 LLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDR---------FGRRR--VLLIGLLLFALGLLLLLFASSL----W 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 301 WILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTV 380
Cdd:pfam07690 87 LLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAV 166
|
170 180
....*....|....*....|
gi 1820395190 381 VFFLLRNIRTKMGRVSKKGE 400
Cdd:pfam07690 167 LLLLPRPPPESKRPKPAEEA 186
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
237-385 |
1.45e-03 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 40.61 E-value: 1.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 237 ISALEVGGLVGSIAAGYLSDRAmakaglslygnPRHGLLLLMMAGMAASMFLfrvtvTSDSPKIWILVLG-AVFGFSSYG 315
Cdd:cd17324 40 VSAYALGYALGALLLGPLSDRI-----------ERRRLLLVLLLLFILGNLL-----AALAPSFALLLLArALAGLAHGG 103
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1820395190 316 PIALFGVIANESAPPNLCGTSHAIVgLMANVGGFLAGLPFST-IAKHYSWSTAFWVAEVVCGASTVVFFLL 385
Cdd:cd17324 104 FWAIAAAYAADLVPPEKRGRAIGLV-FSGLTLGLVLGRPLGGlLGQLLGWRAAFLAIAVLALLAALLLWRL 173
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
227-385 |
2.69e-03 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 39.48 E-value: 2.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 227 GQSALVGSSYISALEVgglVGSIAAGYLSDRAMakaglslygnpRHGLLLLMMAGMAASMFL---FRVTVTSDSPKIWIL 303
Cdd:cd17315 213 GTASILASIIVGVVNL---LATLVAIRLVDKVG-----------RRPLLLIGFAGMAASLLLlaiAFLLPALAKAAGWLA 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 304 VLGA---VFGFS-SYGPIalFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGAST 379
Cdd:cd17315 279 LLGIllyIAAFAmGAGPV--PWLLLSEIFPLRIRGKGMAIATLVNWIFNFIVGLTFLIMVSTIGLAGVFIFFAAVCLLAL 356
|
....*..
gi 1820395190 380 V-VFFLL 385
Cdd:cd17315 357 VfVFFFV 363
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
17-386 |
3.15e-03 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 39.48 E-value: 3.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 17 PFAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKIL 96
Cdd:cd17473 34 ELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALI 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 97 RKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAqSYSWRSTLALSGALCVVVSFFCLLLihnepadvglrnLDPAPSK 176
Cdd:cd17473 114 GDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALA-EIGWRAPFLVYLLALPVLILVLLFL------------PEPARKS 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 177 GKKGSSKEESTLQDLLLSPYLWVLST--GYLVVFGVKTcctdwGQFFLIQERG-QSALVGSSYISALEVGGLVGSIAAGY 253
Cdd:cd17473 181 KSAASPGAATAAALPWKRVLPIYFLAflAMLLFYVIPI-----QLPFLLQERGgGSAALIGLALAIASLAGAIGALLFGR 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 254 LSDRAmakaglslygnPRHGLLLLMMAGMAASMFLFrvtvtSDSPKIWILVLGAV---FGFSSYGPIALfgVIANESAPP 330
Cdd:cd17473 256 LKRRL-----------GKRRLLAIGFALMALGFLLL-----ALASGLWVVLLGAIlagLGFGLLLPTLN--SWAMSLVPP 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1820395190 331 NLCGTSHAIVGLMANVGGFLAGLPFSTIAKHY-SWSTAFWVAEVVCGASTVVFFLLR 386
Cdd:cd17473 318 ELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTgGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
67-385 |
3.31e-03 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 39.48 E-value: 3.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 67 WSSTVSAFAALWFLNGLAQGLGWPPCGKILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRS---TLALS 143
Cdd:cd17320 83 LASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAifvFLALL 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 144 GALCVVVSFFCLllihnepadvglrnldPAPSKGKKGSSKEESTLQD---LLLSPYLWVLSTGYLVVFGVKTCCTDWGQF 220
Cdd:cd17320 163 GLLLLLLVLLFL----------------PETLPEEKRKPLLSSLLRAykrVLKNRRFLGYALALGLSFAGLFAYLAAAPF 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 221 FLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRAMAKAGLslygnpRHGLLLLMMAGMAasMFLFRVTVTSDSPKI 300
Cdd:cd17320 227 IYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLL------RLGLLLLLAAALV--LLLAALLGGLSLWPL 298
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 301 WILVLGAVFGFSSYGPIALFGVIaneSAPPNLCGTSHAIVGLMANVGGFLAGlpfSTIAkhYSWSTAFWVAEVVCGASTV 380
Cdd:cd17320 299 VAPLFLIFFGFGLIFPNATSLAL---EPFPHVAGTASALLGFLQFLIGALAG---ALVG--LLPNGTALPMGLLILVLGL 370
|
....*
gi 1820395190 381 VFFLL 385
Cdd:cd17320 371 LALLL 375
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
17-383 |
4.06e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 39.06 E-value: 4.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 17 PFAAGLITSSQSAAYAISKFVSGVLSDQMSARWLF-SSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKI 95
Cdd:cd17370 33 AAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRKPLvILGYGLSALAKPLLALAGSWQLVLLLRILERLGKGIRTPPRDAL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 96 LRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATIL--AQSYSWRSTLALSgALCVVVSFFCLLLIHNEPadvglrnldPA 173
Cdd:cd17370 113 LADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLlyLLGGNYRTIFLLA-AIPALLALLILLFVVKEY---------PR 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 174 PSKGKKGSSKEESTlqdlLLSPYLWVlstgYLVVFGVKTCCTDWGQFFLI--QERGQSALVGSSYISALEVGGLVGSIAA 251
Cdd:cd17370 183 PPKLRKKSKKTSLK----KLPKAFWL----YLLAVALFALGNFSFAFLILraQELGLSAALIPLLYALFNLVYALAAYPA 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 252 GYLSDRamakaglslygNPRHGLLLLMMAGMAASMFLFrvtvtSDSPKIWILVLGAVFGFSSYGPI-ALFGVIANESAPP 330
Cdd:cd17370 255 GRLSDR-----------IGRKKLLILGYLSLALAYLGF-----ALGSSLWLLLLGFILWGLYMGAQeSIERAAVADLVPA 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1820395190 331 NLCGTS----HAIVGLMANVGGFLAGLpfstIAKHYSWSTAFWVAEVVCGASTVVFF 383
Cdd:cd17370 319 ELRGTAyglfNTVVGIGWLLASLIAGY----LWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
29-159 |
4.49e-03 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 37.24 E-value: 4.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 29 AAYAISKFVSGVLSDQMSARW------LFSSGLLLVGLVNVVFSWSSTVsaFAALWFLNGLAQGLGWPPCGKILRKWFEP 102
Cdd:TIGR00880 5 AGYALGQLIYSPLSGLLTDRFgrkpvlLVGLFIFVLSTAMFALSSNITV--LIIARFLQGFGAAFALVAGAALIADIYPP 82
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1820395190 103 SQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIH 159
Cdd:TIGR00880 83 EERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLP 139
|
|
| MFS_SLC49 |
cd17334 |
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The ... |
80-384 |
5.68e-03 |
|
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The Solute carrier 49 (SLC49) family is composed of four members: feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1); FLVCR2 (SLC49A2); major facilitator superfamily domain-containing protein 7 (MFSD7, SLC49A3); and disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. In addition, FLVCR2 also functions as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The function of MFSD7 is unknown. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. The SLC49 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340892 [Multi-domain] Cd Length: 407 Bit Score: 38.54 E-value: 5.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 80 LNGLAQG--LGWPPcgKILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQS-----YSWRSTLALSGALCVVVSF 152
Cdd:cd17334 105 LNALAQVlvLSLPP--LIAAVWFPPKERTTATAIASLANFLGCAIGFLLPPVVVPPpkgtkKEFGAVFYGEFGFACLLLA 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 153 FCLLLIHNEPAdvglrnldPAPSKGKKGSSKEESTLQDLLLSPYLWVLSTGY---LVVFGVKTCC-----TDWGQFFLIQ 224
Cdd:cd17334 183 LVLALFPPKPK--------YPPSAASARQQNSEHVILELQKSISELLRNEPFvllAVAFSIMMGVfagfsSVLAQILLPF 254
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 225 E--RGQSALVGSSYIsaleVGGLVGSIAAGYLSDRA-MAKaglslygnpRHGLLLLMMAGMAASMFLFRVTVTSDSPKIW 301
Cdd:cd17334 255 GvsQTSAGWLGFFGI----VAGMVGGLLLGLFVDRTrMFK---------LIGLIILALGTVVCTFFMLLVDRYGLPYVTL 321
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 302 IL-VLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTA--FWVAEVVCGAS 378
Cdd:cd17334 322 AFyLLCGLLGFFQNSMVPIMFELAVELTYPVPESVSTGVLTALANLFSFLLMLVFSELLGPTPTESKylLWFILCTVGSC 401
|
....*.
gi 1820395190 379 TVVFFL 384
Cdd:cd17334 402 LGALFF 407
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
228-385 |
6.63e-03 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 38.41 E-value: 6.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 228 QSALVGSSYISALEVGGL--VGSIAAGYLSDRAmakaglslygnPRHGLLLLMMAGMAASMFL-----FRVTVTSDSPKI 300
Cdd:pfam00083 282 ENLGLSDSFLVTIIVGVVnfVFTFIAIFLVDRF-----------GRRPLLLLGAAGMAICFVIlgivaLLGVSKSDWAGI 350
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 301 WILVLGAVFGFS---SYGPIalFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGA 377
Cdd:pfam00083 351 VAIVFIALFIAFfamGWGPV--PWVIVSELFPLSVRSKAMALATAANWLANFLIGFLFPIITDAIGLGYTFFIFAGLLVL 428
|
....*....
gi 1820395190 378 ST-VVFFLL 385
Cdd:pfam00083 429 FIiFVFFFV 437
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
17-146 |
7.18e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 38.33 E-value: 7.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395190 17 PFAAGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSW---SSTVSAFAALWFLNGLAQGLGWPPCG 93
Cdd:cd17503 213 AFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFltpDTSLWLIILPLFIRGLGMGLVFMPLN 292
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1820395190 94 KILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGAL 146
Cdd:cd17503 293 TLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLTNRTQFHHSRLSELL 345
|
|
| |
