|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
10-417 |
0e+00 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 635.14 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 10 RTVIFAAMFGGYSLYYFNRKTFSFVMPSLVDEIALDKDDLGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGL 89
Cdd:cd17343 1 QLTIFASMFVGYTLYYFNRKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 90 VNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTL 169
Cdd:cd17343 81 TTVAFSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGWRSTL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 170 ALSGALCVVVSFFCLLLIHNEPADVGLRNLDPAPSKGK-KGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQ 248
Cdd:cd17343 161 SISGTVAVVMSVVCLLFIKNEPSDVGLNNIEEEESKGKkKKSPRGESTLKELLLSPFLWLLSLGYLVVFGVKTAVTDWGQ 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 249 FFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRAMAKAGLSLYGNPRHGLLLLMMAGMAASMFLFRVTVTSDSPK 328
Cdd:cd17343 241 LFLIQDKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWAVAKHGSSSRGNPRMPLALVFMAGLTVSLHLFRVHITSDSSE 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 329 IWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGAST 408
Cdd:cd17343 321 LFILLLGFLIGFSLYGPIAIFGVIANESAPSHLCGTSHAIVALAANVGGVLAGLPFSYIAKHYDWRTAFLLLEILCAITV 400
|
....*....
gi 1820395092 409 VVFFLLRNI 417
Cdd:cd17343 401 VILFLLRNI 409
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
18-397 |
1.16e-133 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 389.04 E-value: 1.16e-133
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 18 FGGYSLYYFNRKTFSFVMPSLVDEIALDKDDLGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWS 97
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 98 STVSAFAALWFLNGLAQGLGWPPCGKILRKWFEPSQFGTWWAVLSTSMNLAGSLGP-ILATILAQSYSWRSTLALSGALC 176
Cdd:TIGR00881 81 TSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPpLVLFGIAELYSWHWVFIVPGIIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 177 VVVSFFCLLLIHNEPADVGLRNLDPAPS--------KGKKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQ 248
Cdd:TIGR00881 161 IIVSLICFLLLRDSPQSCGLPPAEEMPNeepdgdaeKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGILDWSP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 249 FFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRamakaglsLYGNPRHGLLLLMMAGMAASMFLFRVTVTSDSPk 328
Cdd:TIGR00881 241 LYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDK--------LFNGRRGPLAVFFMALIIVSLLVYWLNPAANPL- 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1820395092 329 iWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAF 397
Cdd:TIGR00881 312 -MDLICLFALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFGWAGAF 379
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
10-415 |
1.26e-109 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 327.31 E-value: 1.26e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 10 RTVIFAAMFGGYSLYYFNRKTFSFVMPSLVDEIALDKDDLGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGL 89
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 90 VNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTL 169
Cdd:cd17312 81 ANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 170 ALSGALCVVVSFFCLLLIHNEPadvglrnldpapskgkkgsskeestlqdlllsPYLWVLSTGYLVVFGVKTCCTDWGQF 249
Cdd:cd17312 161 LVPGIVGLVVAIILFFFLRDSP--------------------------------PYVWVLSLAYAFVYIVRYACLDWGPL 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 250 FLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRamakaglsLYGNPRHGLLLLMMAGMAASMFLFRVTVtsdSPKI 329
Cdd:cd17312 209 YLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDK--------LFGGRRAPIAVIYMLLMTLSLALFWFFP---HNKL 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 330 WILVLGAVFGFSSYGPIALFGVIANESAPP-NLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGAST 408
Cdd:cd17312 278 LSIVLLFLIGFFVGGPINLIGGAAAQDIGRkEAAGTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISAALLSV 357
|
....*..
gi 1820395092 409 VVFFLLR 415
Cdd:cd17312 358 LLLLSLW 364
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
4-413 |
4.32e-72 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 233.06 E-value: 4.32e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 4 QGYGYYRTVIFAAMFGGYSLYYFNRKTFSFVMPSLVDEIALDKDDLGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSG 83
Cdd:PRK11663 15 ARYRYWRRHILITMYLGYALFYFTRKSFNAAMPEMLADLGLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIG 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 84 LLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSY 163
Cdd:PRK11663 95 LIATGIINILFGFSSSLWAFALLWVLNAFFQGWGWPVCAKLLTAWYSRTERGGWWAIWNTAHNVGGALIPLVVGAIALHY 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 164 SWRSTLALSGALCVVVSFFCLLLIHNEPADVGL------RN--LDPAPSKGKKGSSKEESTLQDLLLSPYLWVLSTGYLV 235
Cdd:PRK11663 175 GWRYGMMIAGIIAIVVGLFLCWRLRDKPQAMGLpsvgewRHdaLELAQQQEGAGLSRKEILTKYVLLNPYIWLLSFSYVL 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 236 VFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRamakaglsLYGNPRHGLLLLMMAGMaasm 315
Cdd:PRK11663 255 VYVVRAAINDWGNLYMSETLGVDLVTANSAVSMFELGGFIGALVAGWGSDK--------LFNGNRGPMNLIFAAGI---- 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 316 fLFRVTVTSDSPKIWILVLGAVF---GFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYS 392
Cdd:PRK11663 323 -LLSVGSLWLMPFASYVMQAACFftiGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYLGAALSGYPLAKVLEIWH 401
|
410 420
....*....|....*....|.
gi 1820395092 393 WsTAFWVAEVVCGASTVVFFL 413
Cdd:PRK11663 402 W-TGFFVVISIAAGISALLLL 421
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
10-414 |
2.37e-64 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 210.73 E-value: 2.37e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 10 RTVIFAAMFGGYSLYYFNRKTFSFVMPSLVDEIALDKDDLGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGL 89
Cdd:cd17488 1 RIHILASMFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 90 VNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTL 169
Cdd:cd17488 81 INILFGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYGWRAGM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 170 ALSGALCVVVSFFCLLLIHNEPadvglrnldpapskgkkgsskeestlqdlllsPYLWVLSTGYLVVFGVKTCCTDWGQF 249
Cdd:cd17488 161 YVPGIIAILMGIVLCWRLRDRP--------------------------------PYIWLLAFCYVLVYVVRTAINDWGNL 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 250 FLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRamakaglsLYGNPRHGLLLLMMAGMAASMFLfrVTVTSDSPKI 329
Cdd:cd17488 209 YLSETHGYSLVKANSAVSLFEVGGLIGALVAGWGSDK--------LFKGNRGPMNLIFALGLLVSVGA--LWLVPVHSYW 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 330 WILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTV 409
Cdd:cd17488 279 LLATCFFTIGFFVFGPQMLIGMAAAECSHKDAAGSATGFVGLFAYLGAALAGYPLAKVIESWGWSGFFIVISIAAAISGL 358
|
....*
gi 1820395092 410 VFFLL 414
Cdd:cd17488 359 LLLPL 363
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
10-415 |
9.31e-58 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 194.77 E-value: 9.31e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 10 RTVIFAAMFGGYSLYYFNRKTFSFVMPSLVDEIALDKDDLGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGL 89
Cdd:cd17345 1 RWQVFLGIFIGYAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 90 VNVVF----SWSSTVSAFAALWFLNGLAQGLGWPPCGKILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQ---S 162
Cdd:cd17345 81 INILIgfvpSATSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAifgD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 163 YSWRSTLALSGALCVVVSFFCLLLIHNEPADVGLRNL-----DPAPSKGKKGSSKEESTLQDL----LLSPYLWVLSTG- 232
Cdd:cd17345 161 GWWRGAFIFPAIIAIIVAVIVLFLGKDTPESEGLPPIeeykgDYPEEADGEEEEQELSAWEIFvkyvLKNKLLWYIAIAn 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 233 ---YLVVFGVktccTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRamakaglsLYGNPRHGLLLLMMA 309
Cdd:cd17345 241 vfvYLVRYGI----LDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDK--------LFKGRRAPTGIIFMI 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 310 GMAASMFlfrVTVTSDSPkIWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGG-FLAGLPFSTIA 388
Cdd:cd17345 309 LVIVALI---VYWLAPNV-LVDLIALIALGFLIYGPVMLIGLQALELVPKKAAGTAAGLTGLFGYLGGsVLATALIGIIV 384
|
410 420
....*....|....*....|....*..
gi 1820395092 389 KHYSWSTAFWVAEVVCGASTVVFFLLR 415
Cdd:cd17345 385 DHFGWNGGFIVLLASCILAIIFLALVA 411
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
3-415 |
3.25e-52 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 178.91 E-value: 3.25e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 3 AQGYGYYRTVIFAAMFGGYSLYYFNRKTFSFVMPSLVDEIALDKDDLGLITSSQSAAYAISKFVSGVLSDQMSARWLFSS 82
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 83 GLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQS 162
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 163 YSWRSTLALSGALCVVVSFFclllihnepadvglrnldpapskgkkgsskeestlqdlllspYLWVLSTGYLVVFGVKTC 242
Cdd:COG2271 161 FGWRAAFLILGLPGLLLALL------------------------------------------RFWLLALAYFLVYFALYG 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 243 CTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRamakaglslYGNPRHGLLLLMMAGMAASMFLFRVTv 322
Cdd:COG2271 199 FLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDR---------LGRRRKLVLAIGLLLAALALLLLALL- 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 323 tsdSPKIWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEV 402
Cdd:COG2271 269 ---PSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAA 345
|
410
....*....|...
gi 1820395092 403 VCGASTVVFFLLR 415
Cdd:COG2271 346 LALLAALLALLLL 358
|
|
| glpT |
TIGR00712 |
glycerol-3-phosphate transporter; This model describes a very hydrophobic protein, predicted ... |
6-414 |
1.03e-39 |
|
glycerol-3-phosphate transporter; This model describes a very hydrophobic protein, predicted to span the membrane at least 8 times. The two members confirmed experimentally as glycerol-3-phosphate transporters, from E. coli and B. subtilis, share more than 50 % amino acid identity. Proteins of the hexose phosphate and phosphoglycerate transport systems are also quite similar. [Transport and binding proteins, Other]
Pssm-ID: 129795 [Multi-domain] Cd Length: 438 Bit Score: 147.68 E-value: 1.03e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 6 YGYYRTVIFAAMFGGYSLYYFNRKTFSFVMPSLVdEIALDKDDLGLITSSQSAAYAISKFVSGVLSDQMSARWLFSS--- 82
Cdd:TIGR00712 21 YKRLRWQVFLGIFFGYAAYYLVRKNFALAMPYLV-EQGFSKGELGFALSAISIAYGFSKFIMGSVSDRSNPRVFLPAgli 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 83 GLLLVGLVNVVFSW-SSTVSAFAALWFLNGLAQGLGWPPCGKILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATI-LA 160
Cdd:TIGR00712 100 LSAAVMLLMGFVPWaTSSIAIMFVLLFLNGWFQGMGWPPCGRTMVHWWSQSERGTIVSIWNCAHNIGGGIPPLLVLLgMA 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 161 QSYSWRSTLALSGALCVVVSFFCLLLIHNEPADVGLRNL--------DPAPSKGKKGSSKEESTLQDLLLSPYLWVLSTG 232
Cdd:TIGR00712 180 WFNDWHAALYFPAICAIIVALFAFAMMRDTPQSCGLPPIeeyrndypDDYNEKAEQELTAKEIFMQYVLPNKLLWYIAIA 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 233 YLVVFGVKTCCTDWGQFFLIQERGqSALVGSSYISAL-EVGGLVGSIAAGYLSDRamakaglsLYGNPRHGLLLLMMAGM 311
Cdd:TIGR00712 260 NVFVYLLRYGVLDWSPTYLKEVKH-FALDKSSWAYFLyEYAGIPGTLLCGWMSDK--------VFKGNRGATGVFFMTLV 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 312 AASMFLFRVTVTSDSPKIWILVLgaVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFL-AGLPFSTIAKH 390
Cdd:TIGR00712 331 TIAVIVYWMNPAGNPLVDMICMI--VIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVaASAIVGYTVDF 408
|
410 420
....*....|....*....|....
gi 1820395092 391 YSWSTAFWVaeVVCGASTVVFFLL 414
Cdd:TIGR00712 409 FGWDGGFMV--MIGGSILAVILLI 430
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
9-415 |
1.36e-31 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 124.22 E-value: 1.36e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 9 YRTVIFAAMFGGYSLYYFNRKTFSFVMPSLVDEIALDKDDLGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVG 88
Cdd:COG2223 2 GRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 89 LVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRST 168
Cdd:COG2223 82 IGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 169 LALSGALCVVVSFFCLLLIHNEPADVglrnldpapskgKKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQ 248
Cdd:COG2223 162 FLILGILLLVVAVLAWLFLRDPPAGA------------AAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLP 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 249 FFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRAmakaglslygnPRHGLLLLMMAGMAASMFLFrvTVTSDSPK 328
Cdd:COG2223 230 PYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRI-----------GGRRVLLIVFALMALGLLLL--ALALGSLW 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 329 IWILVLGAVFGFSSYGPIALFGVIAnESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHY-SWSTAFWVAEVVCGAS 407
Cdd:COG2223 297 LFLVLFLLLGLALGGGNGAVFALVP-DIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATgSYTAAFLVFAVLALVA 375
|
....*...
gi 1820395092 408 TVVFFLLR 415
Cdd:COG2223 376 LVLTLLLY 383
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
6-413 |
3.57e-31 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 124.05 E-value: 3.57e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 6 YGYYRTVIFAAMFGGYSLYYFNRKTFSFVMPSLVDEiALDKDDLGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLL 85
Cdd:PRK11273 23 YRRLRWQIFLGIFFGYAAYYLVRKNFALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLI 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 86 LVGLVNVVFSW----SSTVSAFAALWFLNGLAQGLGWPPCGKILRKWFEPSQFGTWWAVLSTSMNLAGSL-GPILATILA 160
Cdd:PRK11273 102 LAAAVMLFMGFvpwaTSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGLpPLLFLLGMA 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 161 QSYSWRSTLALSGALCVVVSFFCLLLIHNEPADVGL------RNLDPA--PSKGKKGSSKEESTLQDLLLSPYLWVLSTG 232
Cdd:PRK11273 182 WFNDWHAALYMPAFAAILVALFAFAMMRDTPQSCGLppieeyKNDYPDdyNEKHEQELTAKQIFMQYVLPNKLLWYIAIA 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 233 YLVVFGVKTCCTDWGQFFLiQERGQSALVGSSYISAL-EVGGLVGSIAAGYLSDRAMAkaglslyGNprhgllllmmAGM 311
Cdd:PRK11273 262 NVFVYLLRYGILDWSPTYL-KEVKHFALDKSSWAYFLyEYAGIPGTLLCGWMSDKVFR-------GN----------RGA 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 312 AASMFLFRVTVTS--------DSPKIWILVLGAVfGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGlp 383
Cdd:PRK11273 324 TGVFFMTLVTIATivywlnpaGNPTVDMACMIVI-GFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAA-- 400
|
410 420 430
....*....|....*....|....*....|....
gi 1820395092 384 fSTI----AKHYSWSTAFWVAEVVCGASTVVFFL 413
Cdd:PRK11273 401 -SAIvgytVDFFGWDGGFMVMIGGSILAVILLIV 433
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
10-414 |
7.39e-28 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 113.05 E-value: 7.39e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 10 RTVIFAAMFGGYSLYYFNRKTFSFVMPSLVDEIALDKDDLGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGL 89
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 90 VNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTL 169
Cdd:cd17319 81 FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 170 ALSGALCVVVSFFCLLLIhnePADVGLrnldpapskgkkgsskeesTLQDLLLSPYLWVLSTgylvvfgvktcctdWGQF 249
Cdd:cd17319 161 IIEGLLGLLLAVLWWFYL---RQVWGL-------------------ALGYFGINYALYGLLT--------------WLPT 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 250 FLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRAMAKAglslygnpRHGLLLLMMAGMAASMFLFrvtVTSDSPKI 329
Cdd:cd17319 205 YLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGA--------RRLVIIIGLLLAAVGLLLA---YLTTSPVV 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 330 WILVLGAVFGFsSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKH-YSWSTAFWVAEVVCGAST 408
Cdd:cd17319 274 AVILLSLAGFG-IGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDAtGSYTAAFLFLAAVALLAA 352
|
....*.
gi 1820395092 409 VVFFLL 414
Cdd:cd17319 353 LLVLLL 358
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
8-380 |
7.69e-28 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 112.76 E-value: 7.69e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 8 YYRTVIFAAMFGGYSLYYFNRKTFSFVMPSLVDEIALDKDDLGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLV 87
Cdd:COG2814 6 RRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 88 GLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRS 167
Cdd:COG2814 86 ALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRW 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 168 TLALSGALCVVVSFFCLLLIhnepadvglrnldpaPSKGKKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWG 247
Cdd:COG2814 166 VFLVNAVLALLALLLLLRLL---------------PESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 248 QFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRAmakaglslygnPRHGLLLLMMAGMAASMFLFRVTVTSdsp 327
Cdd:COG2814 231 PLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRF-----------GRRRLLLIGLLLLALGLLLLALAGSL--- 296
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1820395092 328 kIWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLA 380
Cdd:COG2814 297 -WLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
17-380 |
8.55e-28 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 112.90 E-value: 8.55e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 17 MFGGYSLYYFNRKTFSFVMPS-LVDEIALDKDDLGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFS 95
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 96 WSSTVSAFAALWFLNGLAQGLGWPPCGKILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGAL 175
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 176 CVVVSFFCLLLIHNEPAdvglrnldPAPSKGKKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTdwGQFFLIQER 255
Cdd:pfam07690 161 SLLAAVLLLLPRPPPES--------KRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLT--YLPLYQEVL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 256 GQSALVGSSYISALEVGGLVGSIAAGYLSDRAmakaglslygnPRHGLLLLMMAGMAASMFLFrVTVTSDSPKIWILVLG 335
Cdd:pfam07690 231 GLSALLAGLLLGLGGLLGAIGRLLLGRLSDRL-----------GRRRRLLLALLLLILAALGL-LLLSLTLSSLWLLLAL 298
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1820395092 336 AVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLA 380
Cdd:pfam07690 299 LLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
17-413 |
1.80e-25 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 106.74 E-value: 1.80e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 17 MFGGYSLYYFNRKTFSFVMPSLVDEIALDKDDLGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSW 96
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 97 SSTVSAFAALWFLNGLAQGLGWPPCGKILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQ--SYSWRSTLALSGA 174
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 175 LCVVVSFFCLLLIHNEPADVGLRNLDPAPSKGKKGsskeestLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQE 254
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASSKSVLKL-------LKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 255 RGQSALVGSSYISALEVGGLVGSIAAGYLSDRamakaglslyGNPRHGLLLLMMAGMAASMFLFRVTvtsdSPKIWILVL 334
Cdd:cd06174 234 GGLSVAVAGLLLSLFGLAGALGSLLLGLLSDR----------LIGRKPLLLIGLLLMALGLALLLLA----PSLLLLLLL 299
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1820395092 335 GAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFFL 413
Cdd:cd06174 300 LLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
36-411 |
1.07e-20 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 93.07 E-value: 1.07e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 36 PSLVDEIALDKDDLGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQG 115
Cdd:cd17475 20 PFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 116 LGWPPCGKILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIHNEpadvg 195
Cdd:cd17475 100 SVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREP----- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 196 lrnldPAPSKGKKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLV 275
Cdd:cd17475 175 -----PAASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGAL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 276 GSIAAGYLSDRamakaglsLYGNPRHGLLLLMMAgmAASMFLFRVTVTSDSPKIWILVLG-AVFGFSSYGPIALFGVIAN 354
Cdd:cd17475 250 GRIGLGRVSDR--------VFGGRRRPVLVITAA--IAAAALLVLSLLSPGTPLWLLVLLlILLGLFAIGWNGLYLTLVA 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1820395092 355 ESAPPNLCGTSHAIVGLMANVGGFLAGLPF-STIAKHYSWSTAFWVAEVVCGASTVVF 411
Cdd:cd17475 320 ESAGPEQAGTALGLANTINFIGIAIGPPLFgLLVDATHSYAPAWLALALLLVLAALLL 377
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
14-419 |
2.05e-20 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 93.19 E-value: 2.05e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 14 FAAMFGGYSLYYFNRKTFSFVMPSLVDEIALDKDDLGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVV 93
Cdd:PRK09556 31 YLVVFIGYLTMYLIRKNFKAAQNDMISTYGLSTTELGMIGLGFSITYGVGKTLVGYYADGKNTKQFLPFLLILSAICMLG 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 94 FSWS-----STVSAFAALWFLNGLAQGLGWPPCGKILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRST 168
Cdd:PRK09556 111 FGASlgsgsVSLGLMIALWALSGFFQSTGGPCSYSTITRWTPRRKRGRFLGFWNISHNLGGAGAGGVALWGANYFFDGHV 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 169 LAL---SGALCVVVSFFCLLLIHNEPADVGLRN----LDPAPSKGKKGS-----SKEESTLQDLLLSPYLWVLSTGYLVV 236
Cdd:PRK09556 191 IGMfifPSIIALIIGFIGLRYGSDSPEELGWGKaeeiFGEPISEEDKETestdmTKWQIFVEYVLKNPVIWLLCFANIFL 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 237 FGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRAmakaglslygNPRHGLLLLMMAGMAASMF 316
Cdd:PRK09556 271 YIVRIGIDNWSPVYAFQELGFSKEDAINTFTLFEIGALVGSLLWGWLSDLA----------NGRRALVACIALALIIFTL 340
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 317 LFRVTVTSDspkiwILVLGAVF--GFSSYGPIALFGVIANESAPPN--------------LCGTSHAIVGLMANVGGFLA 380
Cdd:PRK09556 341 GVYQHATSE-----YMYLASLFalGFLVFGPQLLIGVAAVGFVPKKaigvangikgtfayLFGDSFAKVGLGMIADPTKN 415
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 1820395092 381 GLPFSTIAKHySWS---TAFWVAEVVCGA--STVVFFLLRNIRT 419
Cdd:PRK09556 416 GTPIFGYTLT-GWAgtfAALDIAAIGCIClmAIVAVMEERKIRR 458
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
34-415 |
1.59e-17 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 83.78 E-value: 1.59e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 34 VMPSLVDEIALDKDDLGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLA 113
Cdd:cd17325 18 ILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 114 QGLGWPPCGKILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIHNEPad 193
Cdd:cd17325 98 SAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPR-- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 194 vglrnldPAPSKGKKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGG 273
Cdd:cd17325 176 -------PPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLAS 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 274 LVGSIAAGYLSDRAmakaglslygnPRHGLLLLMMAGMAASMFLFRVtvtsdSPKIWILVLGAVF---GFSSYGPiALFG 350
Cdd:cd17325 249 ALSQPPAGKLSDRI-----------GRKPLILIGLLLSAVALLLLPL-----ATSFWLLLLLLALlglGLGLVFP-ATLA 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1820395092 351 VIAnESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFFLLR 415
Cdd:cd17325 312 LLA-DIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
28-412 |
2.22e-17 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 83.47 E-value: 2.22e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 28 RKTFSFVMPSLVDEIALDKDDLGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALW 107
Cdd:cd17355 19 RYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLW 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 108 FLNGLAQ--GLGWPPCGKILRKWFEPSQfGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLL 185
Cdd:cd17355 99 GLLGGGGagTLAAVAFATVAAWWFERRR-GLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 186 LIHNEPADVGLRNLDPAPSKGkkgsskEESTLQDLLLSPYLWVLSTGYLVVfGVKTCCTDWGQFFLIQERGQSALVGSSY 265
Cdd:cd17355 178 LLRRRPADLALRAYDDASPAS------PGSTLKEALRSASFWLLALAFFLC-GFAVVGLIVHLVPYLADRGISPAAAAVA 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 266 ISALEVGGLVGSIAAGYLSDRamakaglslyGNPRHGLLLLMMAGMAASMFLFrvtvTSDSPKIWILVLGAVFGFSSYGP 345
Cdd:cd17355 251 LALIGLFNIVGRLLSGWLGDR----------YSPRRLLAASYALRALGLALLL----LLPFPPLALLLFAALFGLGWGAT 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1820395092 346 IALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHY-SWSTAFWVAEVVCGASTVVFF 412
Cdd:cd17355 317 VPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTgSYTAAWALAVALGLIAALLVL 384
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
34-414 |
2.34e-15 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 77.22 E-value: 2.34e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 34 VMPSLVDEIALDKDDLGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLA 113
Cdd:COG2807 40 LLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAG 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 114 QGLGWPPCGKILRKWFePSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIHNEPAD 193
Cdd:COG2807 120 IAVGNVLLPGLIKRWF-PDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAA 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 194 vglrnldpapskgkKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLiQERGQSALVGSSYISALEVGG 273
Cdd:COG2807 199 --------------AAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPIL-RDAGLSAATAGLLLSLFQLAG 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 274 LVGSIAAGYLSDRAmakaglslygNPRHGLLLLMMAGMAASMFLFrVTVTSDSPKIWILVLGAVFGFSsygPIALFGVIA 353
Cdd:COG2807 264 IPGSLLVPLLADRL----------GDRRPLLLLLGLLGLAGLLGL-LLAPGSLPWLWAVLLGLGQGGL---FPLALTLIG 329
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1820395092 354 NESAPPN----LCGTSHAIVGLMANVGGFLAGLPFSTIAkhySWSTAFWVAEVVCGASTVVFFLL 414
Cdd:COG2807 330 LRARTPAeaaaLSGMAQSVGYLLAALGPLLVGALHDATG---SWTAALLLLAALAVLMLVAGLLA 391
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
34-412 |
3.84e-14 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 73.36 E-value: 3.84e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 34 VMPSLVDEIALDKDDLGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLA 113
Cdd:cd17478 18 LLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 114 QGLGWPPCGKILRKwFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIHnepad 193
Cdd:cd17478 98 SAAFHPEGARLASQ-AAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRP----- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 194 vglRNLDPAPSKGKKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTdwgqfFLIQERGQSALVGSSYISALEVGG 273
Cdd:cd17478 172 ---LKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLP-----FYLVQRGYSLVFAGLLLSLFLFAG 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 274 LVGSIAAGYLSDRAMAKAglslygnprhgLLLLMMAGMAASMFLFRVTvtsdsPKIWILVLGAVFGFSSYGPIALFGVIA 353
Cdd:cd17478 244 AIGTLIGGPLSDRFGRRR-----------VIIASLLLAAPFLLLFLLT-----PGIWSYILLVLAGFLLFASFPVTVVLA 307
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1820395092 354 NESAPPNLcGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFF 412
Cdd:cd17478 308 QELLPGNV-GLASGLMMGLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
34-412 |
3.91e-11 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 64.11 E-value: 3.91e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 34 VMPSLVDEIALDKDDLGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLA 113
Cdd:cd17324 21 LLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 114 QGLGWPPCGKILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIhnepad 193
Cdd:cd17324 101 HGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLL------ 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 194 vglrnldPAPSKGKKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGG 273
Cdd:cd17324 175 -------PSLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAG 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 274 LVGSIAAGYLSDRAMAKAglslygnprhglLLLMMAGMAASMFLFrvTVTSDSPKIWILVLgAVFGFSSYGPIALFGVIA 353
Cdd:cd17324 248 VVGSPLAGRLADRGGRRA------------LLIALLLLAAALLLL--TLLGPSPLLLLVGL-VLWGLGFFAAHSALQTRV 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1820395092 354 NESAPPNLcGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFF 412
Cdd:cd17324 313 LRLAPEAR-GLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
34-414 |
8.49e-11 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 62.97 E-value: 8.49e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 34 VMPSLVDEIALDKDDLGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLA 113
Cdd:cd17474 21 ILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 114 QGLGWPPCGKILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAqSYSWRSTLALSGALCVVvSFFCLLLIHNEPad 193
Cdd:cd17474 101 AAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLA-AISWRYPFFLLAALIPV-AFLAILFLLPEP-- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 194 vglrnLDPAPSKGKKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTcctdWGQFFLIQERGQSALVGSSYISALEVGG 273
Cdd:cd17474 177 -----KEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLT----YLPFLLELLYGISPIIIGLLFAGWSVLL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 274 LVGSIAAGYLSDRAmakaglslygNPRHGLLLLMMAGMAASMFLFRVTvtsdsPKIWILVLG-AVFGFSSYGPIALFGVI 352
Cdd:cd17474 248 ALGSLFVGRLLKKR----------FGARRILVIGLLLYALSLLLLGFV-----PSLALLLIAiVLFGLGLGLNLPLLTTL 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1820395092 353 ANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFFLL 414
Cdd:cd17474 313 VTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
14-414 |
8.86e-11 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 63.02 E-value: 8.86e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 14 FAAMFGGYSLYYFNRKTFSFVMPSLVDEIALDKDDLGLITSSQSAAYAISKFVSGVLSDQMSARWL-----FSSGLLLVG 88
Cdd:cd06173 1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLliladLLRALLAAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 89 LVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRST 168
Cdd:cd06173 81 LALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 169 LALSgALCVVVSFFCLLLIHNEPADVGLRNLDPAPSKGKKGsskeestLQDLLLSPYLWVLSTGYLVVFGVKTCCtdWGQ 248
Cdd:cd06173 161 FAIN-ALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREG-------LRYLRRSPLLRLLLLALALFALLGGAL--TVL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 249 F-FLIQERGQSALVGSSYISALE-VGGLVGSIAAGYLSDRamakaglslygNPRHGLLLLMMAGMAASMFLFRVtvtsdS 326
Cdd:cd06173 231 LpLLAKEVLGGGAAGYGLLLAAFgVGALLGALLLGRLSKR-----------RRRGRLLLIGALLLGLALLVLGL-----S 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 327 PKIWILVLGAVFGFSSYGPI-ALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCG 405
Cdd:cd06173 295 PSLWLLLAALFLLGLAGGLFnVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLL 374
|
....*....
gi 1820395092 406 ASTVVFFLL 414
Cdd:cd06173 375 LAALLLLLL 383
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
14-412 |
9.06e-11 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 63.41 E-value: 9.06e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 14 FAAMFGGYSLYYFNRKTFSFVMPSLVDEIALDKDDLGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVV 93
Cdd:cd17328 1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 94 FSWSSTVSAFAALWFLNGLAQGLGWPPCGKILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQS-YSWRSTLALS 172
Cdd:cd17328 81 SSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQAtGGWRWAFRVT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 173 GALCVVVSFFCLLLIHNEPadvglRNldpAPSKGKKGSSKEESTLQDL--LLS--PYLWVLSTGYLVVFGVKTCCTDWGQ 248
Cdd:cd17328 161 GVLGVLLAILLLLFVREPP-----RG---AAEGGVMAKSTATSFLADLkaLAKnpSFILSTLGFTAVSFVTGALAFWAPT 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 249 FFLiqeRGQSALVGSSYISALE------VGGLVGSIAAGYLSDRAMAKaglslygNPRHGLLLLMMAGMAASMFLFRVTV 322
Cdd:cd17328 233 FFL---RAFGVGDLSSADVGLIfgaitcIAGVLGVLLGGILADRLRRK-------TPRADPLVCAVGLLAAAPFLFLALV 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 323 TSDSPKIWILVLGAV---FGFSSYGPIAlfgVIANESAPPNLCGTSHAIVGLMAN-----VGGFLAGLPFSTIAKHY--- 391
Cdd:cd17328 303 LALSNLLLAWVLLFLgefLLSLNWAPVF---AILLYVVIPTRRSTASAIQILLSHllgdaGSPYLIGLISDLLRQNKdsp 379
|
410 420
....*....|....*....|....*.
gi 1820395092 392 -----SWSTAFWVAEVVCGASTVVFF 412
Cdd:cd17328 380 laeaaSLQYALLLCSFVLVLGGFFFL 405
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
34-420 |
1.35e-10 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 62.56 E-value: 1.35e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 34 VMPSLVDEIALDKDDLGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLA 113
Cdd:COG0738 30 LIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLG 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 114 QGLGWPPCGKILRkWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQ---SYSWRSTLALSGALCVVVSFFCLLLIHne 190
Cdd:COG0738 110 LGLLDVAANPYVA-ALGPETAASRLNLLHAFFSLGALLGPLLGGLLILlglSLSWHLPYLILAVLLLLLALLFLRSKL-- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 191 padvglrnldPAPSKGKKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALE 270
Cdd:COG0738 187 ----------PEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFW 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 271 VGGLVGSIAAGYLSDRAmakaglslygnPRHGLLLLMMAGMAASMFLFRVTVTSDSPKIWILVLGavFGFSSYGPIALfg 350
Cdd:COG0738 257 GGMTIGRFLGGFLLKRF-----------GPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVG--LGLSLMFPTIF-- 321
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 351 VIANESAPPNLCGTShAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFFLLRNIRTK 420
Cdd:COG0738 322 SLALDGLGKRTAAAV-SAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRK 390
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
32-382 |
1.90e-10 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 62.37 E-value: 1.90e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 32 SFVMPSLVDEIALDKDDLGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNG 111
Cdd:TIGR00895 37 GFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAG 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 112 LAQGLGWPPCGKILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCL------- 184
Cdd:TIGR00895 117 LGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMrflpesi 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 185 -LLIHNEPADVGLRNLDPAPSKGKKGSSK--EESTLQDLLLSPYLWVLSTGYL---VVFGVKTCCTDWGQFF-------L 251
Cdd:TIGR00895 197 dFLVSKRPETVRRIVNAIAPQMQAEAQSAlpEQKSTQGTKRSVFKALFQGKTAritVLLWLLYFMLLVGVYFltnwlpkL 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 252 IQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRAmakaglslygNPRHGLLLLMMAGmaasMFLFRVTVTSDSPKIwI 331
Cdd:TIGR00895 277 MVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRL----------GPRVTALLLLLGA----VFAVLVGSTLFSPTL-L 341
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1820395092 332 LVLGAVFGFSSYGPIALFGVIANESAPPNLCGTShaiVGLMANVGGFLAGL 382
Cdd:TIGR00895 342 LLLGAIAGFFVNGGQSGLYALMALFYPTAIRATG---VGWAIGIGRLGAII 389
|
|
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
10-413 |
1.93e-09 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 59.25 E-value: 1.93e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 10 RTVIFAAMFGGYSLYYFNRKTFSFVMPSLVDE---------------------IALDKDD----LGLITSSQSAAYAISK 64
Cdd:cd17342 1 HVVVFILTFFSYALLHATRKTFSNVKPSISAEwtpsnsntsielheetwnanpLFPSQDDaalfLGVLDTIFLFSYAIGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 65 FVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAF------AALWFLNGLAQGLGWPPCGKILRKWFEPSQFGTWW 138
Cdd:cd17342 81 FISGWLGDRLNLRLVLAFGMCSSAITVFLFGVLTEWLHFynkylyCILWVLNGLLQSTGWPCVVAIMGNWFGKSSRGFVL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 139 AVLSTSmnlaGSLGPILATILAQS-------YSWRSTLALSGALCVVVsFFCLLlihNEPADVGLRNLDPAPSKgkkgss 211
Cdd:cd17342 161 GLWSAC----ASVGNIIGALLASSvldygyeYAFLVTSSLLFAGAIVV-FFGLL---SSPPGVIPYSLAYACLK------ 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 212 keestlqdlllspylwvlSTGYLVVFgvktcctdWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRaMAKa 291
Cdd:cd17342 227 ------------------LVNYSFFF--------WLPFYLSNNFHWKESEADQLSIWYDVGGIIGGIVAGYISDR-MGS- 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 292 glslygnpRHGLLLLMMAGMAASMFLFRvtvTSDSPKIWILVLGAVFGFSSYGPIALF--GVIANESAPPNLCGTSHAiv 369
Cdd:cd17342 279 --------RSPVVVVMLLLAIPSLFVYS---HSPSDKVLNAFVMTITGFFIGGPANLIssAISADLGRQPQLRGSSEA-- 345
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....
gi 1820395092 370 glMANVGGFLAG----------LPFSTIAKHYSWSTAFWVAeVVCGASTVVFFL 413
Cdd:cd17342 346 --LATVTGIIDGtgsigaaigqVLVPLIQNRLGWMWVFYFF-IIMTILTIVCIL 396
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
14-412 |
1.75e-08 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 56.07 E-value: 1.75e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 14 FAAMFGGYSLYYFNRKTFSFVMPSLVDEI--ALDKDDLGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVN 91
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFslGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 92 VVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKILRKWFEPSQFGTWWAVLSTSMN----LAGSLGPILATILAQSYSWRS 167
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWAlgalLAALVASLLIPLLSGDWGWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 168 TLALSGALCVVVsffclllihnepadvglrnldpapskgkkgsskeestlqdLLLSPYLWVLSTGYLVVFGVKTCCTDWG 247
Cdd:cd17316 161 LFLIGALPALLA----------------------------------------LLLRRRTLLLILLWFFISFGYYGLTTFL 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 248 QFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRAmakaglslygnPRHGLLLLMMAGMAASMFLFrvTVTSDSP 327
Cdd:cd17316 201 PTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRI-----------GRKKTLVIGLILSGILALPL--FYLLSGS 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 328 KIWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMAN-VGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGA 406
Cdd:cd17316 268 PTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRlGGGGAPPLIALLLASTGGTGVPALILALLAIV 347
|
....*.
gi 1820395092 407 STVVFF 412
Cdd:cd17316 348 ALIVAL 353
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
14-414 |
7.10e-08 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 54.23 E-value: 7.10e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 14 FAAMFGGYSLYYFNRKTFSFVMPSLVDEIALDKDDLGLITSSQSAAYAISKFVSGVLSDQMSARwlfssglLLVGLVNVV 93
Cdd:cd17371 1 FWAAFLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRV-------RVLVITILL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 94 FSWSSTVSAFAALW-------FLNGLAQGLGWPPCGKILRKWFEPSQFGTWWAVLSTSMN----LAGSLGPILATILAQS 162
Cdd:cd17371 74 FAVFTLLCGFAQNYwqllilrALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAvgwlLATLLAALLFPLLPPE 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 163 YSWRsTLALSGALCVVVSFFCLLLIHNEPAdvglrnldPAPSKGKKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTC 242
Cdd:cd17371 154 IAWR-VLFLLGALPALLVLFIRRFVKEPPQ--------WQAARAARRHFADRPSLRELFSPPLLRTTLLASLLATGALGG 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 243 C---TDWGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRAMAKAGLSLYGnprhgllLLMMAGMAASMFLfr 319
Cdd:cd17371 225 YygiTTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFA-------LGSAISILLYFFL-- 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 320 vtvtSDSPKIwILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTShaiVGLMANVGGFLAGL-PFST--IAKHYSWSTA 396
Cdd:cd17371 296 ----PLSPTL-ILILGFPLGFFASGPFSGMGAYLTELFPTAVRATA---QGFCYNVGRIIGALfPFLVgfLATSGSLGTA 367
|
410
....*....|....*....
gi 1820395092 397 F-WVAEVVCGASTVVFFLL 414
Cdd:cd17371 368 IaVFAAVYYIAGLVLALLL 386
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
10-186 |
7.22e-08 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 53.66 E-value: 7.22e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 10 RTVIFAAMFGGYSLYYFNRKTFSFVMPSLVDEIALDKDDLGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGL 89
Cdd:COG0477 12 RRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 90 VNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTL 169
Cdd:COG0477 92 ASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIF 171
|
170
....*....|....*..
gi 1820395092 170 ALSGALCVVVSFFCLLL 186
Cdd:COG0477 172 LINAPLGLLALVLRLRL 188
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
31-414 |
1.21e-07 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 53.41 E-value: 1.21e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 31 FSFVMPSLVDEIALDKDDLGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWS-STVSAFAALWFL 109
Cdd:cd17341 18 FAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAvSSYWGLLVLGFL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 110 NGLAqGLGWPPCGKILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQS-------YSWRSTLALSGALCVVVSFF 182
Cdd:cd17341 98 LGFA-GANFASGQPWASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAGAivfdggfVGWRNAFFVPGILLAIAAVL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 183 CLLLIHNEPadvglrnldpapsKGKKGSSKEESTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDW-GQFFliQERGQSALV 261
Cdd:cd17341 177 VLLFGDDLP-------------TGKASALEFLKVQLAVLKNYRTWILSLLYGVTFGSFVGFSNVlPTYF--KTRFGLPLV 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 262 GSSYISALevGGLVGSI---AAGYLSDRAMAKaglslygnprhGLLLLMMAGMAASMFLFRVTVTSDSPKIWILVLGAVF 338
Cdd:cd17341 242 TAGILAAL--FPLAGALarpAGGWLSDRFGGR-----------RRLWWLFIVMTIGAALLSLSLPTSGTNLVLFLALFVA 308
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1820395092 339 GFSSYGPI--ALFGVIANESapPNLCGTSHAIVGLMANVGGFLAGLPFSTIAK-HYSWSTAFWvaevVCGASTVVFFLL 414
Cdd:cd17341 309 LGLGAGAGngSVFRMVPFIF--RRELGAVTGLVGAIGGLGGFFLPLLFGSSALmTGSGVGAFS----LFGVLAVACTLL 381
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
35-413 |
1.64e-07 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 53.09 E-value: 1.64e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 35 MPSLVDEIALDKDDLGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQ 114
Cdd:cd17333 19 GPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 115 GLGwPPCGKILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILAT-ILAQSYSWRSTLALSGALCVVVsfFCLLLIHNEPAD 193
Cdd:cd17333 99 GIL-DTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATsLLTSELSWSWAYLIIGLIYLLL--AILILLTLFPEL 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 194 VGLRNLDPAPSKGKKGSSKEestlqdlLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEVGG 273
Cdd:cd17333 176 PSARNPQQSVGAFSASASRL-------LRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGI 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 274 LVGSIAAGYLSDRAMAKAglslygnprhgllLLMMAGMAASMFLFRVTVTSDspKIWILVLGAVFGFSSYGPIALFGVIA 353
Cdd:cd17333 249 TIGRLLGGPISRRIKPHT-------------LLVLSGSGALLGLLILLLAPT--LVVGLVATALLGLFMAALFPTILSLG 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1820395092 354 NESAP-PNLCGTSHAIVglMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFFL 413
Cdd:cd17333 314 ISNLPyAKGKGTSVLLA--AGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFVLALL 372
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
32-415 |
1.22e-06 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 50.28 E-value: 1.22e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 32 SFVMPSLVDEIALDKDDLGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNG 111
Cdd:cd17365 19 GFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 112 LAQGLGWPPCGKILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFclllihnep 191
Cdd:cd17365 99 LGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPL--------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 192 advglrnldpapskgkkgsskeestlqdLLLSPYLWVLS-TGYLVVFGVKTcctdWGQfFLIQERGQSALVGSSYISALE 270
Cdd:cd17365 170 ----------------------------LRGTLLLWVTFfMGLLLVYLLNS----WLP-KLMVEAGYSLSQALTITLLLN 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 271 VGGLVGSIAAGYLSDRamakaglslygNPRHGLLLLMMAGMAASMFLFrvtVTSDSPKIWILVLGAVFGFSSYGPIALFG 350
Cdd:cd17365 217 IGGVIGSLLLGWLADR-----------FGPKRVLALFFALGAVSLALL---GVSPASLVLLYVLVFLAGACVNGAQVGLY 282
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1820395092 351 VIANESAPPNLCGT----SHAIVGLMANVGGFLAGLpfsTIAKHYSWSTAFWVAEVVCGASTVVFFLLR 415
Cdd:cd17365 283 ALAARFYPTEVRATgvgwALGVGRLGAILGPLLGGL---LLAAGLGPESVFLALAIPAALGALAVLLLR 348
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
30-400 |
5.88e-06 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 47.99 E-value: 5.88e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 30 TFSFVMPSLVDEIALDKDDLGLITSSQSAAYAISKFVSGVLSDQMSARW--LFSSGLLLVGLVNVVFSwSSTVSAFAALW 107
Cdd:cd17353 21 AWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKaiLIGGILFGLGFILSAFA-ISLPLLFLGYG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 108 FLNGLAQGLGWPPCGKILRKWFePSQFGtwwavLSTSMNLAG-SLGPI----LATILAQSYSWRSTLALSGALCVVVSFF 182
Cdd:cd17353 100 VLGGIGAGIGYITPVSTAVKWF-PDKRG-----LATGIVIAGfGLGSLifspLIAYLINTVGVPTTFLILGIIFLIIIVI 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 183 CLLLIHNEPADVGlrNLDPAPSKGKKGSSKEESTLQDLLLSPYLWVLstgYLVVFgvktCCTDWGQF-------FLIQER 255
Cdd:cd17353 174 GAFLIRDPPKGWV--PPGVDPLANNAENSPRDYTPREMLRTPTFWLL---WLMFF----LNATAGLMligqakpIGQEFA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 256 GQSALVGSSYISALEVGGLVGSIAAGYLSDRamakaglslYGnpRHGLLLLMMAGMAASMFLFrvtVTSDSPKIWILVLG 335
Cdd:cd17353 245 GLDAGIAALAVSILSIFNGGGRPFWGWLSDK---------IG--RKNTLSIAFLIQGVAMFLL---PFIGSVAVLFVLGV 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1820395092 336 AVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVA 400
Cdd:cd17353 311 ALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIA 375
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
249-414 |
8.84e-06 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 47.62 E-value: 8.84e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 249 FFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRamakaglslYGNPRhgLLLLMMAGMAASMFLFRVTVTsdspk 328
Cdd:cd17475 20 PFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDR---------FGERR--VLAVGLLLMGAAALLMALVGS----- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 329 IWILVLGAVFGFSSYGPIALFGVIA-NESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGAS 407
Cdd:cd17475 84 YPVLLVLLFLVGAGYGSVQPGGGRAiMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILA 163
|
....*..
gi 1820395092 408 TVVFFLL 414
Cdd:cd17475 164 AVLFWLF 170
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
26-208 |
1.20e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 47.22 E-value: 1.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 26 FNRKTFSFVMPS----LVDEIALDKDDLGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVS 101
Cdd:cd17329 10 LNRLGFFMVWPFmaiyLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPW 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 102 AFAALWFLNGLAQGLGWPPCGKILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSwrSTLALSGALCVVVSF 181
Cdd:cd17329 90 LFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSF--RLLFLAAAVLFLLAA 167
|
170 180
....*....|....*....|....*..
gi 1820395092 182 FCLLLIHNEPADVGLRNLDPAPSKGKK 208
Cdd:cd17329 168 LVLLFLLPETRPKRRAAEKTEILRGYK 194
|
|
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
49-348 |
3.11e-05 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 45.77 E-value: 3.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 49 LGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTvSAFAALWF------LNGLAQGLGWPPCG 122
Cdd:cd17344 64 LGALDSAFLFAYAIGMFFSGHIGERLPLRYFLSFGMLLSGLFTALFGLGYY-WNIHSLWYfvvvqiLAGLFQSTGWPSVV 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 123 KILRKWFEPSQ----FGTWwavlstsmNLAGSLGPILATILAQ---SYSWRSTLALSGALCVVVSFFCLLLIHNEPADVg 195
Cdd:cd17344 143 ACVGNWFGKGKrgliMGIW--------NSHTSVGNILGSLIAGifvSSAWGLSFIVPGIIIAAMGVLVFLFLVEHPPGV- 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 196 lrnldpapskgkkgsskeestlqdlllSPYLWVLSTGYLVVFGVKTcctdWGQFFLIQERGQSALVGSSYISALEVGGLV 275
Cdd:cd17344 214 ---------------------------IEFSLCLFFAKLVSYTFLY----WLPLYISNTAILSAKKAGDLSTLFDVGGIV 262
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1820395092 276 GSIAAGYLSDRAMAKAGLSlygnprhgllLLMMAGMAASMFLFRvTVTSDSPKIWILVLgAVFGFSSYGPIAL 348
Cdd:cd17344 263 GGILAGYISDYTGGRATTC----------AAMLILAAPMLFIYN-YFGQVSMTTNIVLL-IVCGLLVNGPYAL 323
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
139-412 |
4.01e-05 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 45.62 E-value: 4.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 139 AVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLihnepadvglrnldPAPSKGKKGSSKEESTLQ 218
Cdd:cd17471 128 SVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFL--------------LPSVKPPAQKATPASSLV 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 219 DLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSA-LVGS--SYISALEVgglVGSIAAGYLSDRAmakaglsl 295
Cdd:cd17471 194 KAPVNRRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSEsWVGLlfGLAAALEI---PIMLLAGLLAKRF-------- 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 296 ygnprhGLLLLMMAGMAASMFLFRVTVTSDSPkiWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANV 375
Cdd:cd17471 263 ------GKRRLLLAGFLAGVLFYLGLALATSL--WQLIALQLLNAIFIGITAGLGISYFQDLMPGQPGLATTLYSNASRI 334
|
250 260 270
....*....|....*....|....*....|....*..
gi 1820395092 376 GGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTVVFF 412
Cdd:cd17471 335 GSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALVLLL 371
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
250-414 |
5.54e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 44.96 E-value: 5.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 250 FLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRAmakaglslygnPRHGLLLLMMAGMAASMFLFrvtVTSDSPkI 329
Cdd:COG2814 35 LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRF-----------GRRRVLLLGLLLFALGSLLC---ALAPSL-W 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 330 WILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTV 409
Cdd:COG2814 100 LLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALL 179
|
....*
gi 1820395092 410 VFFLL 414
Cdd:COG2814 180 LLLRL 184
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
45-187 |
6.09e-05 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 44.92 E-value: 6.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 45 DKDDLGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVS--AFAALWFLNGLAQGLGWPPCG 122
Cdd:cd17318 54 SEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGygALIVLRILQGLAQGVTFPAMH 133
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1820395092 123 KILRKWFEPSQFGtwwaVLSTSMNLAGSLGPI----LATILAQSYSWRSTLALSGALCVVVSFFCLLLI 187
Cdd:cd17318 134 ALWAKWAPPLERS----RLTSIAYSGSQFGTViampLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLV 198
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
12-415 |
6.76e-05 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 44.85 E-value: 6.76e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 12 VIFAAMFGGYSLYYFNrKTFSFVMPSLVDEIALDKDDLGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVN 91
Cdd:cd17352 4 VVFASFLVNFFTDGIL-NSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 92 VVFSWSSTVSAF-AALWFLNGLAQGLGWPPCGKILRKWFEPsqfgtwWAVLSTSMNLAGS-LG----PILATILAQSYSW 165
Cdd:cd17352 83 LLSSFATSLWQLyLTYGVLGGLGLGLIYSPAIVIVGQYFEK------KRGLATGIAVAGSgVGtfvfPPLLRYLLDNYGW 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 166 RSTLALSGALCVVVSFFCLLLIhnepadvglrnldpapskgkkgsskeestlqdLLLSP-YLWVLSTGYLVVFGVKTCCT 244
Cdd:cd17352 157 RGALLILGGLCLNLCVCGLLLR--------------------------------LLKDPtFVLLALGVSFAMLGFFVPFV 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 245 dwGQFFLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRamakaglSLYGNPRHGLLLLMMAGMAASMFLFRVTVTS 324
Cdd:cd17352 205 --YLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADK-------PRIGRLYLYIFTLLILGLSLLAFPLATTYVG 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 325 dspkiwILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGfLAGLPFS--TIAKHYSWSTAFWVAEV 402
Cdd:cd17352 276 ------LIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAA-LVGPPIAglLRDYTGDYDAAFYFCGA 348
|
410
....*....|...
gi 1820395092 403 VCGASTVVFFLLR 415
Cdd:cd17352 349 CLLLSGVLLFLLP 361
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
35-377 |
8.78e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 44.47 E-value: 8.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 35 MPSLVDEIALDKDDLGLITSSQSAAYAISKFVSGVLSDQMSARWLFssglllvGLVNVVFSWSSTVSAFA-ALWFLNG-- 111
Cdd:cd17321 19 LPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVF-------LIGLALFGLASLLCALApSLAFLIAar 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 112 LAQGLG---WPPCG-KILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVsffcllli 187
Cdd:cd17321 92 ALQGIGaaaIMPASlALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVA-------- 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 188 hnepadvglrnldpapskgkkgsskeestlqdLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYIS 267
Cdd:cd17321 164 --------------------------------LLLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALL 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 268 ALEVGGLVGSIAAGYLSDRAMAKAglslygnprhgLLLLMMAGMAASMFLFRVTVTSDSPKIWILVLgAVFGFSSYGPIA 347
Cdd:cd17321 212 PLALAMLVAAPLAGRLADRFGPRL-----------VLVAGLLLTAVGLLLLALLGADSSVWLLLPGL-VLLGLGLGLFAT 279
|
330 340 350
....*....|....*....|....*....|
gi 1820395092 348 LFGVIANESAPPNLCGTSHAIVGLMANVGG 377
Cdd:cd17321 280 PLTNAALSSVPKEKAGAASGILNTARQLGG 309
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
15-187 |
1.21e-04 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 44.08 E-value: 1.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 15 AAMFGGYSLYYFNRKTFSFVMPSLVDEIALDKDDLGLITSSQSAAYAISKFVSGVLSDQMSARW--LFSSGLLLVGLVNV 92
Cdd:cd17380 2 ILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKvlLLAVALWSLATLLT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 93 VFSWSSTVSAFAALWFLNGLAQGLGWPPCGKILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALS 172
Cdd:cd17380 82 PLLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFF 161
|
170
....*....|....*
gi 1820395092 173 GALCVVVSFFCLLLI 187
Cdd:cd17380 162 GLLGLLWALVWLIYL 176
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
13-415 |
1.31e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 43.74 E-value: 1.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 13 IFAAMFGGYSLYYFnrktFSFVMPSLVDEIALDKDDLGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNV 92
Cdd:cd17489 1 ILLANFFFFLSFYL----LLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 93 VFSWSSTVSAFAALWFLNGLAQGLGWPPCGKILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRStLALS 172
Cdd:cd17489 77 LYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAV-LFIV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 173 GALCVVVSFFCLLLIHNEPADVGLRNLdpaPSKGKKGSSKEESTLQDLLLspyLWVLSTGY------LVVFGVKTCCTDW 246
Cdd:cd17489 156 AAVLALLALLLVFLVKDPPPVAAEEAE---AGTRAFRRLVEKKVLPPALI---LFLASIAYgaistfLPLYAAERGISNA 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 247 GQFFLIQergQSALVGSSYISalevgglvgsiaaGYLSDramakaglslygnpRHGLLLLMMAGM---AASMFLFrvtvt 323
Cdd:cd17489 230 GLFFTVY---AIALLLSRPFS-------------GKLSD--------------RKGPKTVIIPGLlllALGLLLL----- 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 324 SDSPKIWILVLGAVF---GFSSYGPIalFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVA 400
Cdd:cd17489 275 SFAGSPWMLLLAAVLyglGFGLLFPA--LQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLA 352
|
410
....*....|....*
gi 1820395092 401 EVVCGASTVVFFLLR 415
Cdd:cd17489 353 AVVVLLALVLYIFLL 367
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
35-410 |
4.76e-04 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 42.25 E-value: 4.76e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 35 MPSLVDEIALDKDDLGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQ 114
Cdd:cd17393 22 IPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFGAAN 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 115 GLG---WPPCGKILRKWFEPSQFGTWWAVLSTSMNLAGSLGpiLATILAQSYSWRSTLALSGALCVVVSFFCLLLihneP 191
Cdd:cd17393 102 GALdvaMNAQGVAVERAYGRPIMSSLHAMWSLGGLAGALLG--AAAIGAGVSPGVHLLAAAVLLLLAALVAIRAL----L 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 192 ADVGLRNLDPAPSKGKKGSskeestlqdLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQERGQSALVGSSYISALEV 271
Cdd:cd17393 176 PGTGEAAEDRPDGAGKPGF---------LLPNRLLLLLGLLALAAALAEGAAADWSALYLRDVLGASAALAALGYAVFSL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 272 GGLVGSIAAGYLSDRAMAKAGLSLYGnprhgllLLMMAGMAASMFlfrvtvtsdSPKIWILVLGAV---FGFSSYGPIAL 348
Cdd:cd17393 247 AMTVGRLFGDRLVDRFGDVAVLRAGA-------LLAALGLLLALL---------APSVWVALAGFAlmgLGLSVVVPLAF 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1820395092 349 FGVIANESAPPNLCGTSHAIVGLmanvGGFLAGLP-FSTIAKHYSWSTAFWVAEVVCGASTVV 410
Cdd:cd17393 311 SAAGALPGLAAGIAVARVATLGY----LGFLVGPPlIGFLADATGLRTAFLVVALLALLVALL 369
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
32-427 |
5.47e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 42.20 E-value: 5.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 32 SFVMPSLVDEIALDKDDLGLITSSQSAAYAISKFVSGVLSDQMSARW-----------LFSSGLLLVGLVNVVFSWSSTV 100
Cdd:COG2211 31 AYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWgrrrpwiligaIPLALSFVLLFTAPDLSPTGKL 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 101 SAFAALWFLNGLAQGLGWPPC----GKILRKWFEPSQFGTWWAVLStsmNLAGSLGPILATILAQSYS------WRSTLA 170
Cdd:COG2211 111 IYALVTYLLLGLAYTLVNIPYsalgAELTPDYEERTRLSSWRFAFA---GLGGLLASVLPPPLVAAFGgdaalgYRLTAL 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 171 LSGALCVVVSFFCLLLIHnepadvglrnlDPAPSKGKKGSSKEesTLQDLLLSPYLWVLSTGYLVVFGVKTCCTDWGQFF 250
Cdd:COG2211 188 IFAVLGLLAFLLTFFGTK-----------ERPVPEEEKVSLKE--SLKALLKNRPFLLLLLAYLLFFLALALVAALLLYY 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 251 LIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRamakaglslYGnpRHGLLLLMMAGMAASMFLFRVTVTSDSPkiW 330
Cdd:COG2211 255 FKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKR---------FG--KKKAFIIGLLLAALGLLLLFFLGPGNLW--L 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 331 ILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSH----------------------AIVGLMANVGGFLAGLPFSTIA 388
Cdd:COG2211 322 LLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTGRrreglyfgiftfaiklgqalagALAGLLLALFGYVAGAAQSPSA 401
|
410 420 430
....*....|....*....|....*....|....*....
gi 1820395092 389 KHYSWSTAFWVAEVVCGASTVVFFLLRNIRTKMGRVSKK 427
Cdd:COG2211 402 LTGIRLLFFLLPAVLLLLAALLLLFYPLTRERHAEIRAE 440
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
250-429 |
6.31e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 41.63 E-value: 6.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 250 FLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRamakaglslYGNPRhgLLLLMMAGMAASMFLFRVTVTSdspkI 329
Cdd:pfam07690 22 LLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDR---------FGRRR--VLLIGLLLFALGLLLLLFASSL----W 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 330 WILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGASTV 409
Cdd:pfam07690 87 LLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAV 166
|
170 180
....*....|....*....|
gi 1820395092 410 VFFLLRNIRTKMGRVSKKGE 429
Cdd:pfam07690 167 LLLLPRPPPESKRPKPAEEA 186
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
266-414 |
6.82e-04 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 41.77 E-value: 6.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 266 ISALEVGGLVGSIAAGYLSDRAmakaglslygnPRHGLLLLMMAGMAASMFLfrvtvTSDSPKIWILVLG-AVFGFSSYG 344
Cdd:cd17324 40 VSAYALGYALGALLLGPLSDRI-----------ERRRLLLVLLLLFILGNLL-----AALAPSFALLLLArALAGLAHGG 103
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1820395092 345 PIALFGVIANESAPPNLCGTSHAIVgLMANVGGFLAGLPFST-IAKHYSWSTAFWVAEVVCGASTVVFFLL 414
Cdd:cd17324 104 FWAIAAAYAADLVPPEKRGRAIGLV-FSGLTLGLVLGRPLGGlLGQLLGWRAAFLAIAVLALLAALLLWRL 173
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
256-414 |
1.83e-03 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 40.25 E-value: 1.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 256 GQSALVGSSYISALEVgglVGSIAAGYLSDRAMakaglslygnpRHGLLLLMMAGMAASMFL---FRVTVTSDSPKIWIL 332
Cdd:cd17315 213 GTASILASIIVGVVNL---LATLVAIRLVDKVG-----------RRPLLLIGFAGMAASLLLlaiAFLLPALAKAAGWLA 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 333 VLGA---VFGFS-SYGPIalFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGAST 408
Cdd:cd17315 279 LLGIllyIAAFAmGAGPV--PWLLLSEIFPLRIRGKGMAIATLVNWIFNFIVGLTFLIMVSTIGLAGVFIFFAAVCLLAL 356
|
....*..
gi 1820395092 409 V-VFFLL 414
Cdd:cd17315 357 VfVFFFV 363
|
|
| MFS_SLC49 |
cd17334 |
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The ... |
109-413 |
1.93e-03 |
|
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The Solute carrier 49 (SLC49) family is composed of four members: feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1); FLVCR2 (SLC49A2); major facilitator superfamily domain-containing protein 7 (MFSD7, SLC49A3); and disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. In addition, FLVCR2 also functions as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The function of MFSD7 is unknown. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. The SLC49 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340892 [Multi-domain] Cd Length: 407 Bit Score: 40.08 E-value: 1.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 109 LNGLAQG--LGWPPcgKILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQS-----YSWRSTLALSGALCVVVSF 181
Cdd:cd17334 105 LNALAQVlvLSLPP--LIAAVWFPPKERTTATAIASLANFLGCAIGFLLPPVVVPPpkgtkKEFGAVFYGEFGFACLLLA 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 182 FCLLLIHNEPAdvglrnldPAPSKGKKGSSKEESTLQDLLLSPYLWVLSTGY---LVVFGVKT-CCTDWGQFF--LIQ-- 253
Cdd:cd17334 183 LVLALFPPKPK--------YPPSAASARQQNSEHVILELQKSISELLRNEPFvllAVAFSIMMgVFAGFSSVLaqILLpf 254
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 254 --ERGQSALVGSSYIsaleVGGLVGSIAAGYLSDRA-MAKaglslygnpRHGLLLLMMAGMAASMFLFRVTVTSDSPKIW 330
Cdd:cd17334 255 gvSQTSAGWLGFFGI----VAGMVGGLLLGLFVDRTrMFK---------LIGLIILALGTVVCTFFMLLVDRYGLPYVTL 321
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 331 IL-VLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTA--FWVAEVVCGAS 407
Cdd:cd17334 322 AFyLLCGLLGFFQNSMVPIMFELAVELTYPVPESVSTGVLTALANLFSFLLMLVFSELLGPTPTESKylLWFILCTVGSC 401
|
....*.
gi 1820395092 408 TVVFFL 413
Cdd:cd17334 402 LGALFF 407
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
96-414 |
2.08e-03 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 40.25 E-value: 2.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 96 WSSTVSAFAALWFLNGLAQGLGWPPCGKILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRS---TLALS 172
Cdd:cd17320 83 LASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAifvFLALL 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 173 GALCVVVSFFCLllihnepadvglrnldPAPSKGKKGSSKEESTLQD---LLLSPYLWVLSTGYLVVFGVKTCCTDWGQF 249
Cdd:cd17320 163 GLLLLLLVLLFL----------------PETLPEEKRKPLLSSLLRAykrVLKNRRFLGYALALGLSFAGLFAYLAAAPF 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 250 FLIQERGQSALVGSSYISALEVGGLVGSIAAGYLSDRAMAKAGLslygnpRHGLLLLMMAGMAasMFLFRVTVTSDSPKI 329
Cdd:cd17320 227 IYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLL------RLGLLLLLAAALV--LLLAALLGGLSLWPL 298
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 330 WILVLGAVFGFSSYGPIALFGVIaneSAPPNLCGTSHAIVGLMANVGGFLAGlpfSTIAkhYSWSTAFWVAEVVCGASTV 409
Cdd:cd17320 299 VAPLFLIFFGFGLIFPNATSLAL---EPFPHVAGTASALLGFLQFLIGALAG---ALVG--LLPNGTALPMGLLILVLGL 370
|
....*
gi 1820395092 410 VFFLL 414
Cdd:cd17320 371 LALLL 375
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
58-188 |
3.82e-03 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 37.63 E-value: 3.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 58 AAYAISKFVSGVLSDQMSARW------LFSSGLLLVGLVNVVFSWSSTVsaFAALWFLNGLAQGLGWPPCGKILRKWFEP 131
Cdd:TIGR00880 5 AGYALGQLIYSPLSGLLTDRFgrkpvlLVGLFIFVLSTAMFALSSNITV--LIIARFLQGFGAAFALVAGAALIADIYPP 82
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1820395092 132 SQFGTWWAVLSTSMNLAGSLGPILATILAQSYSWRSTLALSGALCVVVSFFCLLLIH 188
Cdd:TIGR00880 83 EERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLP 139
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
44-381 |
3.93e-03 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 39.15 E-value: 3.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 44 LDKDDLGLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGK 123
Cdd:cd17327 38 LVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFIL 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 124 ILRKWFEPSQFGTWWAVLSTSMNLAGSLGPILATILAQS------YSWRSTLALSGALCVVVSFFCLLLIHNEPADVGL- 196
Cdd:cd17327 118 YLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKIlgvgglAGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFl 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 197 ----------RNLDPAPSKGKKGSSKeeSTLQDLLLSPYLWVLStgyLVVFGVKTCCTDWGQF-FLIQERGQSALVGSSY 265
Cdd:cd17327 198 teeekelaveRLRANQTGKGDQKFKW--KQIKEAFKDPRTWLLF---LFFFCSQITNNGISNFlPLILKSLGFYSLQTNL 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 266 IS-ALEVGGLVGSIAAGYLSDRAMAKAGLSLYGNprhgllLLMMAGMAASMFLfrvtvtsdSPKIWILVLGAVFGFSSY- 343
Cdd:cd17327 273 LSvPIGALGAVSLLIAALLSDRFKKRGLFAIFAC------VLALVGSIILLAA--------PNPPGAYFAAYILGGGSYa 338
|
330 340 350
....*....|....*....|....*....|....*...
gi 1820395092 344 GPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAG 381
Cdd:cd17327 339 GFPILLSWISSNCAGYTKRATVLAIMLIFYNVGNIVAP 376
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
50-415 |
4.67e-03 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 39.09 E-value: 4.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 50 GLITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKILRKWF 129
Cdd:cd17473 38 PLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYF 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 130 EPSQFGTWWAVLSTSMNLAGSLGPILATILAqSYSWRSTLALSGALCVVVSFFCLLLihnepadvglrnLDPAPSKGKKG 209
Cdd:cd17473 118 EGEERAKMLGLQSAAMSLGGVVFLLLGGALA-EIGWRAPFLVYLLALPVLILVLLFL------------PEPARKSKSAA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 210 SSKEESTLQDLLLSPYLWVLST--GYLVVFGVKTcctdwGQFFLIQERG-QSALVGSSYISALEVGGLVGSIAAGYLSDR 286
Cdd:cd17473 185 SPGAATAAALPWKRVLPIYFLAflAMLLFYVIPI-----QLPFLLQERGgGSAALIGLALAIASLAGAIGALLFGRLKRR 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 287 AmakaglslygnPRHGLLLLMMAGMAASMFLFrvtvtSDSPKIWILVLGAV---FGFSSYGPIALfgVIANESAPPNLCG 363
Cdd:cd17473 260 L-----------GKRRLLAIGFALMALGFLLL-----ALASGLWVVLLGAIlagLGFGLLLPTLN--SWAMSLVPPELRG 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1820395092 364 TSHAIVGLMANVGGFLAGLPFSTIAKHY-SWSTAFWVAEVVCGASTVVFFLLR 415
Cdd:cd17473 322 RAMGIVTSAFFLGQFLSPLVLGPLVNLTgGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
49-412 |
5.75e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 38.68 E-value: 5.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 49 LGLITSSQSAAYAISKFVSGVLSDQMSARWLF-SSGLLLVGLVNVVFSWSSTVSAFAALWFLNGLAQGLGWPPCGKILRK 127
Cdd:cd17370 36 VGLIEGLAEALGSLLRLFSGYLSDRTGKRKPLvILGYGLSALAKPLLALAGSWQLVLLLRILERLGKGIRTPPRDALLAD 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 128 WFEPSQFGTWWAVLSTSMNLAGSLGPILATIL--AQSYSWRSTLALSgALCVVVSFFCLLLIHNEPadvglrnldPAPSK 205
Cdd:cd17370 116 ATPPSGRGKAFGLHRALDTLGAVLGPLLAALLlyLLGGNYRTIFLLA-AIPALLALLILLFVVKEY---------PRPPK 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 206 GKKGSSKEESTlqdlLLSPYLWVlstgYLVVFGVKTCCTDWGQFFLI--QERGQSALVGSSYISALEVGGLVGSIAAGYL 283
Cdd:cd17370 186 LRKKSKKTSLK----KLPKAFWL----YLLAVALFALGNFSFAFLILraQELGLSAALIPLLYALFNLVYALAAYPAGRL 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 284 SDRamakaglslygNPRHGLLLLMMAGMAASMFLFrvtvtSDSPKIWILVLGAVFGFSSYGPI-ALFGVIANESAPPNLC 362
Cdd:cd17370 258 SDR-----------IGRKKLLILGYLSLALAYLGF-----ALGSSLWLLLLGFILWGLYMGAQeSIERAAVADLVPAELR 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1820395092 363 GTS----HAIVGLMANVGGFLAGLpfstIAKHYSWSTAFWVAEVVCGASTVVFF 412
Cdd:cd17370 322 GTAyglfNTVVGIGWLLASLIAGY----LWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
257-414 |
6.92e-03 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 38.41 E-value: 6.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 257 QSALVGSSYISALEVGGL--VGSIAAGYLSDRAmakaglslygnPRHGLLLLMMAGMAASMFL-----FRVTVTSDSPKI 329
Cdd:pfam00083 282 ENLGLSDSFLVTIIVGVVnfVFTFIAIFLVDRF-----------GRRPLLLLGAAGMAICFVIlgivaLLGVSKSDWAGI 350
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820395092 330 WILVLGAVFGFS---SYGPIalFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVVCGA 406
Cdd:pfam00083 351 VAIVFIALFIAFfamGWGPV--PWVIVSELFPLSVRSKAMALATAANWLANFLIGFLFPIITDAIGLGYTFFIFAGLLVL 428
|
....*....
gi 1820395092 407 ST-VVFFLL 414
Cdd:pfam00083 429 FIiFVFFFV 437
|
|
| |
