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Conserved domains on  [gi|1978061440|ref|NP_001365406|]
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nyctalopin precursor [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11471445)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
69-307 4.18e-22

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 98.08  E-value: 4.18e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1978061440  69 LRFLGERAFGTLPSLRRLSLRHNNLSFItPGAFKGLPRLAELRLAHNgDLRYLHArTFAALSRLRRLDLAACRLFSVPEr 148
Cdd:COG4886   101 LDLSGNEELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNN-QLTDLPE-PLGNLTNLKSLDLSNNQLTDLPE- 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1978061440 149 LLAELPALRELAAFDNLFRRVPGALRGLANLTHAHLERGRIEAVaSSSLQGLRRLRSLSLQANRVRAVhaGAFGDCGVLE 228
Cdd:COG4886   177 ELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDL--PELGNLTNLE 253

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1978061440 229 HLLLNDNLLAELPADAfrGLRRLRTLNLGGNALDRVA-RAWFADLAELELLYLDRNSIAFVEEGAFQNLSGLLALHLNGN 307
Cdd:COG4886   254 ELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKlKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLK 331
LRRCT smart00082
Leucine rich repeat C-terminal domain;
331-365 3.19e-06

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 43.96  E-value: 3.19e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1978061440  331 NPWCCDCRLEWLRDWMEGSGRVTDVP---CASPGSVAG 365
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVdlrCASPSSLRG 38
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
69-307 4.18e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 98.08  E-value: 4.18e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1978061440  69 LRFLGERAFGTLPSLRRLSLRHNNLSFItPGAFKGLPRLAELRLAHNgDLRYLHArTFAALSRLRRLDLAACRLFSVPEr 148
Cdd:COG4886   101 LDLSGNEELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNN-QLTDLPE-PLGNLTNLKSLDLSNNQLTDLPE- 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1978061440 149 LLAELPALRELAAFDNLFRRVPGALRGLANLTHAHLERGRIEAVaSSSLQGLRRLRSLSLQANRVRAVhaGAFGDCGVLE 228
Cdd:COG4886   177 ELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDL--PELGNLTNLE 253

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1978061440 229 HLLLNDNLLAELPADAfrGLRRLRTLNLGGNALDRVA-RAWFADLAELELLYLDRNSIAFVEEGAFQNLSGLLALHLNGN 307
Cdd:COG4886   254 ELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKlKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLK 331
LRR_8 pfam13855
Leucine rich repeat;
61-115 5.30e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.62  E-value: 5.30e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1978061440  61 SIDLDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHN 115
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 150-310 8.80e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 58.64  E-value: 8.80e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1978061440 150 LAELPALRELAAFDNLFRRVPGaLRGLANLTHAHLERGRIEAVasSSLQGLRRLRSLSLQANRVRAVhAGaFGDCGVLEH 229
Cdd:cd21340    20 LSLCKNLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRISVV-EG-LENLTNLEE 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1978061440 230 LLLNDNllaELPAD--------AFRGLRR-LRTLNLGGNALDRVarAWFADLAELELLYLDRNSIAFVEE--GAFQNLSG 298
Cdd:cd21340    95 LHIENQ---RLPPGekltfdprSLAALSNsLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEEllDLLSSWPS 169

                         170
                  ....*....|..
gi 1978061440 299 LLALHLNGNRLT 310
Cdd:cd21340   170 LRELDLTGNPVC 181
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 61-310 2.06e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 59.86  E-value: 2.06e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1978061440  61 SIDLDRNGLRF-LGERAFGTLPSLRRLSLRHNNLSFITPGAFkgLPRLAELRLAHN---GDLrYLHARTFaalSRLRRLD 136
Cdd:PLN00113   97 TINLSNNQLSGpIPDDIFTTSSSLRYLNLSNNNFTGSIPRGS--IPNLETLDLSNNmlsGEI-PNDIGSF---SSLKVLD 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1978061440 137 LAACRLFSVPERLLAELPALRELA-AFDNLFRRVPGALRGLANLTHAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRA 215
Cdd:PLN00113  171 LGGNVLVGKIPNSLTNLTSLEFLTlASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTG 250

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1978061440 216 VHAGAFGDCGVLEHLLLNDNLLA-ELPADAFrGLRRLRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQ 294
Cdd:PLN00113  251 PIPSSLGNLKNLQYLFLYQNKLSgPIPPSIF-SLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALT 329

                         250
                  ....*....|....*.
gi 1978061440 295 NLSGLLALHLNGNRLT 310
Cdd:PLN00113  330 SLPRLQVLQLWSNKFS 345
LRRCT smart00082
Leucine rich repeat C-terminal domain;
331-365 3.19e-06

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 43.96  E-value: 3.19e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1978061440  331 NPWCCDCRLEWLRDWMEGSGRVTDVP---CASPGSVAG 365
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVdlrCASPSSLRG 38
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 280-395 1.33e-04

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 44.69  E-value: 1.33e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1978061440  280 LDRNSIAFVEEGAFQNLSGLLALHLNGNrltvlawvafqpgfflgrlflfrnPWCCDCRLEWLRDWMEGSGRVTDVP--- 356
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGN------------------------PFECDCGLARLPRWAEEKGVKVRQPeaa 57

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1978061440  357 -CASPGSVAG---LDLSQVTFG-----------RSSDGLCVDPEELNLTTSSPG 395
Cdd:TIGR00864   58 lCAGPGALAGqplLGIPLLDSGcdeeyvaclkdNSSGGGAARSELVIFSAAHEG 111
LRR smart00370
Leucine-rich repeats, outliers;
80-103 4.62e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 34.63  E-value: 4.62e-03
                           10        20
                   ....*....|....*....|....
gi 1978061440   80 LPSLRRLSLRHNNLSFITPGAFKG 103
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
69-307 4.18e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 98.08  E-value: 4.18e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1978061440  69 LRFLGERAFGTLPSLRRLSLRHNNLSFItPGAFKGLPRLAELRLAHNgDLRYLHArTFAALSRLRRLDLAACRLFSVPEr 148
Cdd:COG4886   101 LDLSGNEELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNN-QLTDLPE-PLGNLTNLKSLDLSNNQLTDLPE- 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1978061440 149 LLAELPALRELAAFDNLFRRVPGALRGLANLTHAHLERGRIEAVaSSSLQGLRRLRSLSLQANRVRAVhaGAFGDCGVLE 228
Cdd:COG4886   177 ELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDL--PELGNLTNLE 253

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1978061440 229 HLLLNDNLLAELPADAfrGLRRLRTLNLGGNALDRVA-RAWFADLAELELLYLDRNSIAFVEEGAFQNLSGLLALHLNGN 307
Cdd:COG4886   254 ELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKlKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLK 331
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
125-312 3.60e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 89.61  E-value: 3.60e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1978061440 125 TFAALSRLRRLDLAACRLfsvperlLAELPALRELAAFDNLFRRVPGALRGLANLTHAHLERGRIEAVaSSSLQGLRRLR 204
Cdd:COG4886    91 DLGDLTNLTELDLSGNEE-------LSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLK 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1978061440 205 SLSLQANRVRAVHAgAFGDCGVLEHLLLNDNLLAELPaDAFRGLRRLRTLNLGGNALDRVArAWFADLAELELLYLDRNS 284
Cdd:COG4886   163 SLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQ 239

                         170       180
                  ....*....|....*....|....*...
gi 1978061440 285 IAFVEEgaFQNLSGLLALHLNGNRLTVL 312
Cdd:COG4886   240 LTDLPE--LGNLTNLEELDLSNNQLTDL 265
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-331 1.04e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 88.07  E-value: 1.04e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1978061440  61 SIDLDRNGLRFLGErAFGTLPSLRRLSLRHNNLSFItPGAFKGLPRLAELRLAHNGdLRYLhARTFAALSRLRRLDLAAC 140
Cdd:COG4886   117 SLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQ-LTDL-PEELGNLTNLKELDLSNN 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1978061440 141 RLFSVPERLlAELPALRELAAFDNLFRRVPGALRGLANLTHAHLERGRIEAVasSSLQGLRRLRSLSLQANRVRAVhaGA 220
Cdd:COG4886   193 QITDLPEPL-GNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTDL--PP 267

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1978061440 221 FGDCGVLEHLLLNDNLLAELPADAFRGLRRLRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQNLSGLL 300
Cdd:COG4886   268 LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLL 347

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1978061440 301 ALHLNGNRLTVLAWVAFQPGFFLGRLFLFRN 331
Cdd:COG4886   348 ALLTLLLLLNLLSLLLTLLLTLGLLGLLEAT 378
LRR_8 pfam13855
Leucine rich repeat;
61-115 5.30e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.62  E-value: 5.30e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1978061440  61 SIDLDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHN 115
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
227-285 1.78e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.08  E-value: 1.78e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1978061440 227 LEHLLLNDNLLAELPADAFRGLRRLRTLNLGGNALDRVARAWFADLAELELLYLDRNSI 285
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
201-261 2.36e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.08  E-value: 2.36e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1978061440 201 RRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLLAELPADAFRGLRRLRTLNLGGNAL 261
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
249-309 4.01e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.30  E-value: 4.01e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1978061440 249 RRLRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQNLSGLLALHLNGNRL 309
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
81-142 4.87e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.92  E-value: 4.87e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1978061440  81 PSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNgDLRYLHARTFAALSRLRRLDLAACRL 142
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNN-LLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 150-310 8.80e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 58.64  E-value: 8.80e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1978061440 150 LAELPALRELAAFDNLFRRVPGaLRGLANLTHAHLERGRIEAVasSSLQGLRRLRSLSLQANRVRAVhAGaFGDCGVLEH 229
Cdd:cd21340    20 LSLCKNLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRISVV-EG-LENLTNLEE 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1978061440 230 LLLNDNllaELPAD--------AFRGLRR-LRTLNLGGNALDRVarAWFADLAELELLYLDRNSIAFVEE--GAFQNLSG 298
Cdd:cd21340    95 LHIENQ---RLPPGekltfdprSLAALSNsLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEEllDLLSSWPS 169

                         170
                  ....*....|..
gi 1978061440 299 LLALHLNGNRLT 310
Cdd:cd21340   170 LRELDLTGNPVC 181
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 68-312 1.61e-09

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 59.29  E-value: 1.61e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1978061440  68 GLRFLGErAFGTLPSLRRLSLRHNNLSFITPGAFKGL---PRLAELRLAHNGdLRYLHARTFAA-----LSRLRRLDLAA 139
Cdd:cd00116    69 GLQSLLQ-GLTKGCGLQELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNG-LGDRGLRLLAKglkdlPPALEKLVLGR 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1978061440 140 CRLFSVP-ERLLAELPA---LRELAAFDNLFRRvpgalRGLANLTHAhlergrieavasssLQGLRRLRSLSLQANRVRA 215
Cdd:cd00116   147 NRLEGAScEALAKALRAnrdLKELNLANNGIGD-----AGIRALAEG--------------LKANCNLEVLDLNNNGLTD 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1978061440 216 VHAGAFGDC----GVLEHLLLNDNLLAELPADAF-----RGLRRLRTLNLGGNALDRVArawFADLAEL-----ELLYLD 281
Cdd:cd00116   208 EGASALAETlaslKSLEVLNLGDNNLTDAGAAALasallSPNISLLTLSLSCNDITDDG---AKDLAEVlaekeSLLELD 284

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1978061440 282 RNSIAFVEEGAFqnLSGLLaLHLNGNRLTVL 312
Cdd:cd00116   285 LRGNKFGEEGAQ--LLAES-LLEPGNELESL 312
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 61-310 2.06e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 59.86  E-value: 2.06e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1978061440  61 SIDLDRNGLRF-LGERAFGTLPSLRRLSLRHNNLSFITPGAFkgLPRLAELRLAHN---GDLrYLHARTFaalSRLRRLD 136
Cdd:PLN00113   97 TINLSNNQLSGpIPDDIFTTSSSLRYLNLSNNNFTGSIPRGS--IPNLETLDLSNNmlsGEI-PNDIGSF---SSLKVLD 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1978061440 137 LAACRLFSVPERLLAELPALRELA-AFDNLFRRVPGALRGLANLTHAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRA 215
Cdd:PLN00113  171 LGGNVLVGKIPNSLTNLTSLEFLTlASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTG 250

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1978061440 216 VHAGAFGDCGVLEHLLLNDNLLA-ELPADAFrGLRRLRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQ 294
Cdd:PLN00113  251 PIPSSLGNLKNLQYLFLYQNKLSgPIPPSIF-SLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALT 329

                         250
                  ....*....|....*.
gi 1978061440 295 NLSGLLALHLNGNRLT 310
Cdd:PLN00113  330 SLPRLQVLQLWSNKFS 345
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
41-290 1.51e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.85  E-value: 1.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1978061440  41 VRCDRAGLLRVPAELPCEAVSIDLDRNGLRFLGERAFGtlpSLRRLSLRHNNLSFITpgafKGLP-RLAELRLAHNgDLR 119
Cdd:PRK15370  183 LRLKILGLTTIPACIPEQITTLILDNNELKSLPENLQG---NIKTLYANSNQLTSIP----ATLPdTIQEMELSIN-RIT 254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1978061440 120 YLHARTFAAlsrLRRLDLAACRLFSVPERLLAElpaLRELAAFDNLFRRVPgalrglanlthAHLERGRIEA-VASSSLQ 198
Cdd:PRK15370  255 ELPERLPSA---LQSLDLFHNKISCLPENLPEE---LRYLSVYDNSIRTLP-----------AHLPSGITHLnVQSNSLT 317

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1978061440 199 GLRRlrslSLQANrvravhagafgdcgvLEHLLLNDNLLAELPADAfrgLRRLRTLNLGGNALDRVARAWFADLAElelL 278
Cdd:PRK15370  318 ALPE----TLPPG---------------LKTLEAGENALTSLPASL---PPELQVLDVSKNQITVLPETLPPTITT---L 372

                         250
                  ....*....|..
gi 1978061440 279 YLDRNSIAFVEE 290
Cdd:PRK15370  373 DVSRNALTNLPE 384
LRR_8 pfam13855
Leucine rich repeat;
274-318 1.52e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 1.52e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1978061440 274 ELELLYLDRNSIAFVEEGAFQNLSGLLALHLNGNRLTVLAWVAFQ 318
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFS 46
LRRCT smart00082
Leucine rich repeat C-terminal domain;
331-365 3.19e-06

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 43.96  E-value: 3.19e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1978061440  331 NPWCCDCRLEWLRDWMEGSGRVTDVP---CASPGSVAG 365
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVdlrCASPSSLRG 38
LRR_8 pfam13855
Leucine rich repeat;
178-237 1.00e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.90  E-value: 1.00e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1978061440 178 NLTHAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLL 237
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 200-309 1.22e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 46.32  E-value: 1.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1978061440 200 LRRLRSLSLQANRVRAVhaGAFGDCGVLEHLLLNDNLLAELPAdaFRGLRRLRTLNLGGNALDRVARawFADLAELELLY 279
Cdd:cd21340     1 LKRITHLYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLY 74

                          90       100       110
                  ....*....|....*....|....*....|
gi 1978061440 280 LDRNSIAFVEegAFQNLSGLLALHLNGNRL 309
Cdd:cd21340    75 LGGNRISVVE--GLENLTNLEELHIENQRL 102
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 81-266 7.35e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.01  E-value: 7.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1978061440  81 PSLRRLSLRHNNLSFITpgAFKGLPRLAELRLAHNgdlrylhartfaalsRLRRLDLaacrlfsvperlLAELPALRELA 160
Cdd:cd21340    24 KNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNN---------------QIEKIEN------------LENLVNLKKLY 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1978061440 161 AFDNLFRRVPGaLRGLANLTHAHLERGRIE-----AVASSSLQGLRR-LRSLSLQANRVRAVHAgaFGDCGVLEHLLLND 234
Cdd:cd21340    75 LGGNRISVVEG-LENLTNLEELHIENQRLPpgeklTFDPRSLAALSNsLRVLNISGNNIDSLEP--LAPLRNLEQLDASN 151

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1978061440 235 NLLAELP--ADAFRGLRRLRTLNLGGNALDRVAR 266
Cdd:cd21340   152 NQISDLEelLDLLSSWPSLRELDLTGNPVCKKPK 185
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 280-395 1.33e-04

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 44.69  E-value: 1.33e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1978061440  280 LDRNSIAFVEEGAFQNLSGLLALHLNGNrltvlawvafqpgfflgrlflfrnPWCCDCRLEWLRDWMEGSGRVTDVP--- 356
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGN------------------------PFECDCGLARLPRWAEEKGVKVRQPeaa 57

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1978061440  357 -CASPGSVAG---LDLSQVTFG-----------RSSDGLCVDPEELNLTTSSPG 395
Cdd:TIGR00864   58 lCAGPGALAGqplLGIPLLDSGcdeeyvaclkdNSSGGGAARSELVIFSAAHEG 111
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 60-310 4.26e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.91  E-value: 4.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1978061440  60 VSIDLDRNGLRflGE--RAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHN---GDLrylhARTFAALSRLRR 134
Cdd:PLN00113  287 ISLDLSDNSLS--GEipELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNkfsGEI----PKNLGKHNNLTV 360

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1978061440 135 LDLAACRLFS-VPERLLAElPALRELAAFDN-LFRRVPGALRGLANLTHAHLERGRIEAVASSSLQGLRRLRSLSLQANR 212
Cdd:PLN00113  361 LDLSTNNLTGeIPEGLCSS-GNLFKLILFSNsLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNN 439

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1978061440 213 VRAVHAGAFGDCGVLEHL-LLNDNLLAELPaDAFRGlRRLRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEG 291
Cdd:PLN00113  440 LQGRINSRKWDMPSLQMLsLARNKFFGGLP-DSFGS-KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPD 517

                         250
                  ....*....|....*....
gi 1978061440 292 AFQNLSGLLALHLNGNRLT 310
Cdd:PLN00113  518 ELSSCKKLVSLDLSHNQLS 536
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 81-115 1.80e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.07  E-value: 1.80e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1978061440  81 PSLRRLSLRHNNLSFITPgaFKGLPRLAELRLAHN 115
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPP--LAKLPNLETLDLSGN 33
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 75-261 3.59e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.83  E-value: 3.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1978061440  75 RAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYLHARTFAaLSRLRRLDLAACRLFsvperllAELP 154
Cdd:PLN00113  398 KSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWD-MPSLQMLSLARNKFF-------GGLP 469

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1978061440 155 alrelaafdNLFrrvpgalrGLANLTHAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLND 234
Cdd:PLN00113  470 ---------DSF--------GSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSH 532

                         170       180
                  ....*....|....*....|....*...
gi 1978061440 235 N-LLAELPAdAFRGLRRLRTLNLGGNAL 261
Cdd:PLN00113  533 NqLSGQIPA-SFSEMPVLSQLDLSQNQL 559
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 144-320 4.29e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 39.39  E-value: 4.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1978061440 144 SVPERLLAELPALRELAAFDNlfRRVPGALRGLANLTHAH-LERGRIEAVASSS----LQGLRRLRSLSLQANRVRAVHA 218
Cdd:COG5238   138 PRRINLIQVLKDPLGGNAVHL--LGLAARLGLLAAISMAKaLQNNSVETVYLGCnqigDEGIEELAEALTQNTTVTTLWL 215

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1978061440 219 G--AFGDCGvlehlllndnllAELPADAFRGLRRLRTLNLGGNALDRVARAWFADLAE----LELLYLDRNSIAfvEEGA 292
Cdd:COG5238   216 KrnPIGDEG------------AEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKnnttVETLYLSGNQIG--AEGA 281

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1978061440 293 ------FQNLSGLLALHLNGNRLTVLAWVAFQPG 320
Cdd:COG5238   282 ialakaLQGNTTLTSLDLSVNRIGDEGAIALAEG 315
LRR smart00370
Leucine-rich repeats, outliers;
80-103 4.62e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 34.63  E-value: 4.62e-03
                           10        20
                   ....*....|....*....|....
gi 1978061440   80 LPSLRRLSLRHNNLSFITPGAFKG 103
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
80-103 4.62e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 34.63  E-value: 4.62e-03
                           10        20
                   ....*....|....*....|....
gi 1978061440   80 LPSLRRLSLRHNNLSFITPGAFKG 103
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_8 pfam13855
Leucine rich repeat;
61-93 4.72e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.58  E-value: 4.72e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1978061440  61 SIDLDRNGLRFLGERAFGTLPSLRRLSLRHNNL 93
Cdd:pfam13855  29 VLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 200-335 6.87e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 39.03  E-value: 6.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1978061440 200 LRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLLAELPADAFRGLRRLRTLNLGGNALD-RVArawfadlAELELL 278
Cdd:PLN03150  441 LRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSgRVP-------AALGGR 513

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1978061440 279 YLDRNSIAFVEEGAfqnLSGLLALHLNGNRLTVLAWVAFQPGFFLGRLFLFRNPWCC 335
Cdd:PLN03150  514 LLHRASFNFTDNAG---LCGIPGLRACGPHLSVGAKIGIAFGVSVAFLFLVICAMCW 567
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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