|
Name |
Accession |
Description |
Interval |
E-value |
| MCM9 |
cd17760 |
DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a ... |
302-561 |
0e+00 |
|
DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a complex with Mcm8 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).
Pssm-ID: 350666 [Multi-domain] Cd Length: 299 Bit Score: 533.28 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 302 GESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLTVTAVKDSGEWNLEAGALVLADAGLCCIDEFNSLKEHD 381
Cdd:cd17760 40 GESHLLLVGDPGTGKSQFLKYAAKITPRSVLTAGIGSTSAGLTVTAVKDGGEWNLEAGALVLADGGLCCIDEFNSLKEHD 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 382 RTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPKGQYDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRIISS 461
Cdd:cd17760 120 RTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPKGQYDPNESISVNIALASPLLSRFDLVLVLLDTKNEDWDRIISS 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 462 FILENKGYPSKSEKLWSMEKMKTYFCLIRNLQPTLSDVGNQVLLRYYQMQRQSDCRNAARTTIRLLESLIRLAEAHARLM 541
Cdd:cd17760 200 FILENKGEPSKSSKLWSMEKMRTYFCLIKNLRPVLSDEANAILLRYYQLQRQSDCRNAARTTIRMLESLIRLAEAHARLM 279
|
250 260
....*....|....*....|
gi 1807799447 542 FRDTVTLEDAITVVSVMESS 561
Cdd:cd17760 280 FRETVTEEDAITVVSVMESS 299
|
|
| Mcm2 |
COG1241 |
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ... |
2-563 |
4.91e-139 |
|
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];
Pssm-ID: 440854 [Multi-domain] Cd Length: 682 Bit Score: 419.97 E-value: 4.91e-139
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 2 NSDQVTLVGQVFESYVseyHKNDILLILkerdedAHYP----VVVNAMTLFETNMEIGEYFNMFPSEVLTIFDSALRrsa 77
Cdd:COG1241 2 ESDLVDKFEEFLRRYK---YRDEILELA------QEYPekrsLVVDYNDLYSFDPDLADDLLENPDEVLEAAEEALR--- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 78 ltilQSLSQPEAVSMKQnLHARISGLPVCPELvrEHIPkTKDVGHFLSVTGTVIRTSLVKVLEFERDYMCNKCKHVFVIk 157
Cdd:COG1241 70 ----EIDLEPYDVSLGD-AHVRITNLPETVPI--RDIR-SDHIGKLISVEGIVRKATEVKPKITEAAFECPRCGTETYV- 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 158 adfEQYYT-FCRPSSCPSlesC----------DSSKFTclsglsssptrcrDYQEIKIQEQVQRLSVGSIPRSMKVILED 226
Cdd:COG1241 141 ---PQTGEkLQEPHECPG---CgrqgpfkllpEKSEFI-------------DAQKIRIQEPPEDLPGGQQPQSIDVILED 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 227 DLVDSCKSGDDLTIYGIVMQRWKPFQQDVRCEVEIVLKANYIQVNNEQSSGI-IMDEE---------------------- 283
Cdd:COG1241 202 DLVGEVRPGDRVTVTGILRIEQRTSGRGKSTIFDLYLEANSIEVEEKEFEEIeITEEDeekikelskdpdiyekiiasia 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 284 --------------------VQKEFEDfweyyKSDpFAGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGL 343
Cdd:COG1241 282 psiygyeeikeaialqlfggVPKVLPD-----GSR-IRGDIHILLVGDPGTAKSQLLRYAARLAPRGVYTSGKGSTAAGL 355
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 344 TVTAVKD---SGEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPK-G 419
Cdd:COG1241 356 TAAAVRDdfgTGRWTLEAGALVLADGGLACIDELDKMREEDRSALHEAMEQQTISIAKAGIVATLNARCSVLAAANPKyG 435
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 420 QYDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRIISSFILEN--KGYPSKSEKLWSMEKMKTYfclI-------- 489
Cdd:COG1241 436 RFDPYEPIAEQIDLPPTLLSRFDLIFVLRDKPDEERDRELARHILKVhrAGELLEQEIEEETEEVKPE---Idpdllrky 512
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 490 -----RNLQPTLSDVGNQVLLRYY-QMQRQSDCRNAART-TIRLLESLIRLAEAHARLMFRDTVTLEDAITVVSVMESSM 562
Cdd:COG1241 513 iayarRNVFPVLTEEAKDLIEDFYvDMRKKGEDEDSPVPiTARQLEALIRLAEASARMRLSDTVTEEDAERAIRLVDSCL 592
|
.
gi 1807799447 563 Q 563
Cdd:COG1241 593 K 593
|
|
| minchrom_main_MCM |
NF040949 |
minichromosome maintenance protein MCM; |
9-563 |
1.36e-132 |
|
minichromosome maintenance protein MCM;
Pssm-ID: 468880 [Multi-domain] Cd Length: 681 Bit Score: 403.54 E-value: 1.36e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 9 VGQVFESYVSEYHKNDILLILKERDED--AHYP--VVVNAMTLFETNMEIGEYFNMFPSEVLTIFDSALRrsaltILQSL 84
Cdd:NF040949 1 LGEKFKEFIRTFRDSFGNEKYKERIFEmiAMRKrsLVVDFNDLYMFDPELADLLIEKPDEVLPAASKALK-----EIVEE 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 85 SQPEAVSMKQNLHARISGLPvcpELVREHIPKTKDVGHFLSVTGTVIRTSLVKVLEFERDYMCNKCKHVFVIKADFEQYY 164
Cdd:NF040949 76 EDPEYAEEVAKFHVRFRNLP---RTVPLRDLRSEYIGKLIAVEGIVTRTTPVKPRIVKAVFRCRDCGCEFEWPEEEEESY 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 165 TFC-RPSSCPSLEScdSSKFTCLSGLSssptRCRDYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGI 243
Cdd:NF040949 153 EIVePPTVCPVCGK--PGSFRLLQEKS----KFIDWQKIVVQERPEELPPGQLPRSIEVVLEDDLVDTARPGDRVTVTGI 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 244 V-MQRWKPFQQDVRCEVEIVLKANYIQVNNEQSSGI-IMDEEVQKEFE--------------------DFWEYYKSDPFA 301
Cdd:NF040949 227 LrIKPDSSLKKGSRPIFKNYIEANHIEVSQKELEEVeITEEDEEKILElakdpwirekiiasiapsiyGHWEIKEAIALL 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 302 ----------------GESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLTVTAVKD--SGEWNLEAGALVL 363
Cdd:NF040949 307 lfggvpkvlpdgtrirGDIHVLIVGDPGTAKSQLLQYVARLAPRAVYTSGKGSTAAGLTAAVVRDklTGEYYLEAGALVL 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 364 ADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPK-GQYDPQESVSVNIALGSPLLSRFD 442
Cdd:NF040949 387 ADGGVAVIDEIDKMREEDRSAIHEAMEQQTVSIAKAGIVATLNARASVLAAGNPKfGRYDPNRSVAENIDLPPTILSRFD 466
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 443 LILVLLDTKNEDWDRIISSFILENKGYPSKSEKLWSMEKMKTYFCLIR-NLQPTLSDVGNQVLLRYY-QMQRQSDCRNAA 520
Cdd:NF040949 467 LIFVIRDKPNEERDRRLARHILDVHSGKEKVKPEIDPDLLKKYIAYARkYVRPKLTEEAKKLIEDFYvEMRKSSKSSEDP 546
|
570 580 590 600
....*....|....*....|....*....|....*....|....*..
gi 1807799447 521 RT----TIRLLESLIRLAEAHARLMFRDTVTLEDAITVVSVMESSMQ 563
Cdd:NF040949 547 DSpipiTARQLEALIRLSEAHAKMRLKDEVTAEDAERAIRLMLAFLE 593
|
|
| MCM |
smart00350 |
minichromosome maintenance proteins; |
116-561 |
9.44e-128 |
|
minichromosome maintenance proteins;
Pssm-ID: 214631 [Multi-domain] Cd Length: 509 Bit Score: 385.08 E-value: 9.44e-128
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 116 KTKDVGHFLSVTGTVIRTSLVKVLEFERDYMCNKCKHVfviKADFEQYYTFCRPSSCPSlESCDS-SKFTCLSGLSsspt 194
Cdd:smart00350 9 RADHLGKLVRISGIVTRTSGVRPKLKRASFTCEKCGAT---LGPEIQSGRETEPTVCPP-RECQSpTPFSLNHERS---- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 195 RCRDYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGIVmqRWKPFQ-----QDVRCEVEIVLKANYIQ 269
Cdd:smart00350 81 TFIDFQKIKLQESPEEVPVGQLPRSVDVILDGDLVDKAKPGDRVEVTGIY--RNVPYGfklntVKGLPVFATYIEANHVR 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 270 VNNEQSSGIIMDEEVQK----EFEDFWEYYKSD-----------P-----------------------------FAGESH 305
Cdd:smart00350 159 KLDYKRSFEDSSFSVQSlsdeEEEEIRKLSKDPdiyerlarslaPsiyghedikkaillllfggvhknlpdgmkIRGDIN 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 306 LLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLTVTAVKD--SGEWNLEAGALVLADAGLCCIDEFNSLKEHDRT 383
Cdd:smart00350 239 ILLCGDPGTAKSQLLKYVEKTAPRAVYTTGKGSSAVGLTAAVTRDpeTREFTLEAGALVLADNGVCCIDEFDKMDDSDRT 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 384 SIHEAMEQQTISVAKAGLVCKLNTRTTILAATNP-KGQYDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRIISSF 462
Cdd:smart00350 319 AIHEAMEQQTISIAKAGITTTLNARCSVLAAANPiGGRYDPKLTPEENIDLPAPILSRFDLLFVVLDEVDEERDRELAKH 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 463 ILENKGY-----PSKSEKLWSMEKMKTYFCLIR-NLQPTLSDVGNQVLLRYY----QMQRQSDCRNAARTTIRLLESLIR 532
Cdd:smart00350 399 VVDLHRYshpeeDEAFEPPLSQEKLRKYIAYAReKIKPKLSEEAADKLVKAYvdlrKEDSQTESRSSIPITVRQLESIIR 478
|
490 500
....*....|....*....|....*....
gi 1807799447 533 LAEAHARLMFRDTVTLEDAITVVSVMESS 561
Cdd:smart00350 479 LSEAHAKMRLSDVVEEADVEEAIRLLRES 507
|
|
| MCM |
pfam00493 |
MCM P-loop domain; |
302-466 |
1.61e-88 |
|
MCM P-loop domain;
Pssm-ID: 459830 [Multi-domain] Cd Length: 224 Bit Score: 273.64 E-value: 1.61e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 302 GESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLTVTAVKD--SGEWNLEAGALVLADAGLCCIDEFNSLKE 379
Cdd:pfam00493 56 GDINVLLVGDPGTAKSQLLKYVEKIAPRAVYTSGKGSSAAGLTAAVVRDpvTGEFVLEAGALVLADGGVCCIDEFDKMND 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 380 HDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPK-GQYDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRI 458
Cdd:pfam00493 136 EDRVALHEAMEQQTISIAKAGIVATLNARCSILAAANPIfGRYDPKKSIAENINLPPPLLSRFDLIFVLLDKPDEEKDER 215
|
....*...
gi 1807799447 459 ISSFILEN 466
Cdd:pfam00493 216 LAKHIVDL 223
|
|
| PTZ00111 |
PTZ00111 |
DNA replication licensing factor MCM4; Provisional |
295-561 |
7.80e-56 |
|
DNA replication licensing factor MCM4; Provisional
Pssm-ID: 173403 [Multi-domain] Cd Length: 915 Bit Score: 203.30 E-value: 7.80e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 295 YKSDPFAGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLTVT-AVKDS--GEWNLEAGALVLADAGLCCI 371
Cdd:PTZ00111 484 YKVDNFRGIINVLLCGDPGTAKSQLLHYTHLLSPRSIYTSGKSSSSVGLTASiKFNESdnGRAMIQPGAVVLANGGVCCI 563
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 372 DEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNP-KGQYDPQESVSVNIALGSPLLSRFDLILVLLDT 450
Cdd:PTZ00111 564 DELDKCHNESRLSLYEVMEQQTVTIAKAGIVATLKAETAILASCNPiNSRYNKNKAVIENINISPSLFTRFDLIYLVLDH 643
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 451 KNEDWDRIISSFILENKGYPS---------------------------KSEKLWSMEKMKTY--FCLIrNLQPTLSDVGN 501
Cdd:PTZ00111 644 IDQDTDQLISLSIAKDFLLPHmtgsgndedtydrsntmhvedeslrseKDYNKNDLDMLRMYikFSKL-HCFPKLSDEAK 722
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 502 QVLLRYYQMQRQSD----------------------CRNAART---TIRLLESLIRLAEAHARLMFRDTVTLEDAITVVS 556
Cdd:PTZ00111 723 KVITREYVKMRQGNfqtsnldelehaqedddddlyyQSSGTRMiyvSSRMISSIIRISVSLARMRLSTVVTPADALQAVQ 802
|
....*
gi 1807799447 557 VMESS 561
Cdd:PTZ00111 803 IVKSS 807
|
|
| MCM_OB |
pfam17207 |
MCM OB domain; This family contains an OB-fold found within MCM proteins. This domain contains ... |
116-243 |
6.61e-25 |
|
MCM OB domain; This family contains an OB-fold found within MCM proteins. This domain contains an insertion at the zinc binding motif.
Pssm-ID: 465381 [Multi-domain] Cd Length: 126 Bit Score: 99.86 E-value: 6.61e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 116 KTKDVGHFLSVTGTVIRTSLVK---VLEFerdYMCNKCKHVFVIKadfeqyytFCRPSSCPSlESCDS-SKFTclsgLSS 191
Cdd:pfam17207 6 RSEHIGKLVSVSGIVTRTSEVRpklKKAT---FTCRKCGHTVGVK--------ITEPTKCPN-PECGNkDPFK----LVH 69
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 1807799447 192 SPTRCRDYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGI 243
Cdd:pfam17207 70 EKSKFVDFQKIKIQESPEEVPAGELPRSLDVILDDDLVDRVKPGDRVTVTGI 121
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MCM9 |
cd17760 |
DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a ... |
302-561 |
0e+00 |
|
DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a complex with Mcm8 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).
Pssm-ID: 350666 [Multi-domain] Cd Length: 299 Bit Score: 533.28 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 302 GESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLTVTAVKDSGEWNLEAGALVLADAGLCCIDEFNSLKEHD 381
Cdd:cd17760 40 GESHLLLVGDPGTGKSQFLKYAAKITPRSVLTAGIGSTSAGLTVTAVKDGGEWNLEAGALVLADGGLCCIDEFNSLKEHD 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 382 RTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPKGQYDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRIISS 461
Cdd:cd17760 120 RTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPKGQYDPNESISVNIALASPLLSRFDLVLVLLDTKNEDWDRIISS 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 462 FILENKGYPSKSEKLWSMEKMKTYFCLIRNLQPTLSDVGNQVLLRYYQMQRQSDCRNAARTTIRLLESLIRLAEAHARLM 541
Cdd:cd17760 200 FILENKGEPSKSSKLWSMEKMRTYFCLIKNLRPVLSDEANAILLRYYQLQRQSDCRNAARTTIRMLESLIRLAEAHARLM 279
|
250 260
....*....|....*....|
gi 1807799447 542 FRDTVTLEDAITVVSVMESS 561
Cdd:cd17760 280 FRETVTEEDAITVVSVMESS 299
|
|
| Mcm2 |
COG1241 |
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ... |
2-563 |
4.91e-139 |
|
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];
Pssm-ID: 440854 [Multi-domain] Cd Length: 682 Bit Score: 419.97 E-value: 4.91e-139
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 2 NSDQVTLVGQVFESYVseyHKNDILLILkerdedAHYP----VVVNAMTLFETNMEIGEYFNMFPSEVLTIFDSALRrsa 77
Cdd:COG1241 2 ESDLVDKFEEFLRRYK---YRDEILELA------QEYPekrsLVVDYNDLYSFDPDLADDLLENPDEVLEAAEEALR--- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 78 ltilQSLSQPEAVSMKQnLHARISGLPVCPELvrEHIPkTKDVGHFLSVTGTVIRTSLVKVLEFERDYMCNKCKHVFVIk 157
Cdd:COG1241 70 ----EIDLEPYDVSLGD-AHVRITNLPETVPI--RDIR-SDHIGKLISVEGIVRKATEVKPKITEAAFECPRCGTETYV- 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 158 adfEQYYT-FCRPSSCPSlesC----------DSSKFTclsglsssptrcrDYQEIKIQEQVQRLSVGSIPRSMKVILED 226
Cdd:COG1241 141 ---PQTGEkLQEPHECPG---CgrqgpfkllpEKSEFI-------------DAQKIRIQEPPEDLPGGQQPQSIDVILED 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 227 DLVDSCKSGDDLTIYGIVMQRWKPFQQDVRCEVEIVLKANYIQVNNEQSSGI-IMDEE---------------------- 283
Cdd:COG1241 202 DLVGEVRPGDRVTVTGILRIEQRTSGRGKSTIFDLYLEANSIEVEEKEFEEIeITEEDeekikelskdpdiyekiiasia 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 284 --------------------VQKEFEDfweyyKSDpFAGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGL 343
Cdd:COG1241 282 psiygyeeikeaialqlfggVPKVLPD-----GSR-IRGDIHILLVGDPGTAKSQLLRYAARLAPRGVYTSGKGSTAAGL 355
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 344 TVTAVKD---SGEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPK-G 419
Cdd:COG1241 356 TAAAVRDdfgTGRWTLEAGALVLADGGLACIDELDKMREEDRSALHEAMEQQTISIAKAGIVATLNARCSVLAAANPKyG 435
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 420 QYDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRIISSFILEN--KGYPSKSEKLWSMEKMKTYfclI-------- 489
Cdd:COG1241 436 RFDPYEPIAEQIDLPPTLLSRFDLIFVLRDKPDEERDRELARHILKVhrAGELLEQEIEEETEEVKPE---Idpdllrky 512
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 490 -----RNLQPTLSDVGNQVLLRYY-QMQRQSDCRNAART-TIRLLESLIRLAEAHARLMFRDTVTLEDAITVVSVMESSM 562
Cdd:COG1241 513 iayarRNVFPVLTEEAKDLIEDFYvDMRKKGEDEDSPVPiTARQLEALIRLAEASARMRLSDTVTEEDAERAIRLVDSCL 592
|
.
gi 1807799447 563 Q 563
Cdd:COG1241 593 K 593
|
|
| minchrom_main_MCM |
NF040949 |
minichromosome maintenance protein MCM; |
9-563 |
1.36e-132 |
|
minichromosome maintenance protein MCM;
Pssm-ID: 468880 [Multi-domain] Cd Length: 681 Bit Score: 403.54 E-value: 1.36e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 9 VGQVFESYVSEYHKNDILLILKERDED--AHYP--VVVNAMTLFETNMEIGEYFNMFPSEVLTIFDSALRrsaltILQSL 84
Cdd:NF040949 1 LGEKFKEFIRTFRDSFGNEKYKERIFEmiAMRKrsLVVDFNDLYMFDPELADLLIEKPDEVLPAASKALK-----EIVEE 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 85 SQPEAVSMKQNLHARISGLPvcpELVREHIPKTKDVGHFLSVTGTVIRTSLVKVLEFERDYMCNKCKHVFVIKADFEQYY 164
Cdd:NF040949 76 EDPEYAEEVAKFHVRFRNLP---RTVPLRDLRSEYIGKLIAVEGIVTRTTPVKPRIVKAVFRCRDCGCEFEWPEEEEESY 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 165 TFC-RPSSCPSLEScdSSKFTCLSGLSssptRCRDYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGI 243
Cdd:NF040949 153 EIVePPTVCPVCGK--PGSFRLLQEKS----KFIDWQKIVVQERPEELPPGQLPRSIEVVLEDDLVDTARPGDRVTVTGI 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 244 V-MQRWKPFQQDVRCEVEIVLKANYIQVNNEQSSGI-IMDEEVQKEFE--------------------DFWEYYKSDPFA 301
Cdd:NF040949 227 LrIKPDSSLKKGSRPIFKNYIEANHIEVSQKELEEVeITEEDEEKILElakdpwirekiiasiapsiyGHWEIKEAIALL 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 302 ----------------GESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLTVTAVKD--SGEWNLEAGALVL 363
Cdd:NF040949 307 lfggvpkvlpdgtrirGDIHVLIVGDPGTAKSQLLQYVARLAPRAVYTSGKGSTAAGLTAAVVRDklTGEYYLEAGALVL 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 364 ADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPK-GQYDPQESVSVNIALGSPLLSRFD 442
Cdd:NF040949 387 ADGGVAVIDEIDKMREEDRSAIHEAMEQQTVSIAKAGIVATLNARASVLAAGNPKfGRYDPNRSVAENIDLPPTILSRFD 466
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 443 LILVLLDTKNEDWDRIISSFILENKGYPSKSEKLWSMEKMKTYFCLIR-NLQPTLSDVGNQVLLRYY-QMQRQSDCRNAA 520
Cdd:NF040949 467 LIFVIRDKPNEERDRRLARHILDVHSGKEKVKPEIDPDLLKKYIAYARkYVRPKLTEEAKKLIEDFYvEMRKSSKSSEDP 546
|
570 580 590 600
....*....|....*....|....*....|....*....|....*..
gi 1807799447 521 RT----TIRLLESLIRLAEAHARLMFRDTVTLEDAITVVSVMESSMQ 563
Cdd:NF040949 547 DSpipiTARQLEALIRLSEAHAKMRLKDEVTAEDAERAIRLMLAFLE 593
|
|
| MCM |
cd17706 |
MCM helicase family; MCM helicases are a family of helicases that play an important role in ... |
302-561 |
5.89e-128 |
|
MCM helicase family; MCM helicases are a family of helicases that play an important role in replication and homologous recombination repair. The heterohexameric ring-shaped Mcm2-7 complex is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases. Mcm8 and Mcm9, form a complex required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).
Pssm-ID: 350658 [Multi-domain] Cd Length: 311 Bit Score: 378.22 E-value: 5.89e-128
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 302 GESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLTVTAVKDS--GEWNLEAGALVLADAGLCCIDEFNSLKE 379
Cdd:cd17706 40 GDIHILLVGDPGTAKSQILKYVLKIAPRGVYTSGKGSSGAGLTAAVVRDSetGEWYLEAGALVLADGGVCCIDEFDKMKE 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 380 HDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPKGQ-YDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRI 458
Cdd:cd17706 120 LDRTALHEAMEQQTISIAKAGIVTTLNARCSILAAANPKGGrYNPKLSPIENINLPSPLLSRFDLIFVIRDDPDEERDEE 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 459 ISSFIL--------ENKGYPSKSEKLWSMEKMKTYFCLIRNLQPTLSDVGNQVLLRYYQMQRQSDCRN-AARTTIRLLES 529
Cdd:cd17706 200 LAEHIIdlhrgsdpEEQVKPEEDGIPIDIELLRKYILYARQIHPKISEEAREKLVRWYVELRKESERRsTIPITARQLES 279
|
250 260 270
....*....|....*....|....*....|..
gi 1807799447 530 LIRLAEAHARLMFRDTVTLEDAITVVSVMESS 561
Cdd:cd17706 280 VIRLAEAHAKMRLSEVVTEEDVEEAIRLVRHS 311
|
|
| MCM |
smart00350 |
minichromosome maintenance proteins; |
116-561 |
9.44e-128 |
|
minichromosome maintenance proteins;
Pssm-ID: 214631 [Multi-domain] Cd Length: 509 Bit Score: 385.08 E-value: 9.44e-128
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 116 KTKDVGHFLSVTGTVIRTSLVKVLEFERDYMCNKCKHVfviKADFEQYYTFCRPSSCPSlESCDS-SKFTCLSGLSsspt 194
Cdd:smart00350 9 RADHLGKLVRISGIVTRTSGVRPKLKRASFTCEKCGAT---LGPEIQSGRETEPTVCPP-RECQSpTPFSLNHERS---- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 195 RCRDYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGIVmqRWKPFQ-----QDVRCEVEIVLKANYIQ 269
Cdd:smart00350 81 TFIDFQKIKLQESPEEVPVGQLPRSVDVILDGDLVDKAKPGDRVEVTGIY--RNVPYGfklntVKGLPVFATYIEANHVR 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 270 VNNEQSSGIIMDEEVQK----EFEDFWEYYKSD-----------P-----------------------------FAGESH 305
Cdd:smart00350 159 KLDYKRSFEDSSFSVQSlsdeEEEEIRKLSKDPdiyerlarslaPsiyghedikkaillllfggvhknlpdgmkIRGDIN 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 306 LLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLTVTAVKD--SGEWNLEAGALVLADAGLCCIDEFNSLKEHDRT 383
Cdd:smart00350 239 ILLCGDPGTAKSQLLKYVEKTAPRAVYTTGKGSSAVGLTAAVTRDpeTREFTLEAGALVLADNGVCCIDEFDKMDDSDRT 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 384 SIHEAMEQQTISVAKAGLVCKLNTRTTILAATNP-KGQYDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRIISSF 462
Cdd:smart00350 319 AIHEAMEQQTISIAKAGITTTLNARCSVLAAANPiGGRYDPKLTPEENIDLPAPILSRFDLLFVVLDEVDEERDRELAKH 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 463 ILENKGY-----PSKSEKLWSMEKMKTYFCLIR-NLQPTLSDVGNQVLLRYY----QMQRQSDCRNAARTTIRLLESLIR 532
Cdd:smart00350 399 VVDLHRYshpeeDEAFEPPLSQEKLRKYIAYAReKIKPKLSEEAADKLVKAYvdlrKEDSQTESRSSIPITVRQLESIIR 478
|
490 500
....*....|....*....|....*....
gi 1807799447 533 LAEAHARLMFRDTVTLEDAITVVSVMESS 561
Cdd:smart00350 479 LSEAHAKMRLSDVVEEADVEEAIRLLRES 507
|
|
| MCM_arch |
cd17761 |
archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the ... |
302-561 |
3.92e-90 |
|
archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the eukaryotic Mcm2-7 helicase and also function as the replicative helicase at the replication fork
Pssm-ID: 350667 [Multi-domain] Cd Length: 308 Bit Score: 281.26 E-value: 3.92e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 302 GESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLTVTAVKD--SGEWNLEAGALVLADAGLCCIDEFNSLKE 379
Cdd:cd17761 41 GDIHILLVGDPGTAKSQLLKYVSKVAPRAVYTTGKGSTAAGLTAAVVRDegTGEWYLEAGALVLADKGIAVVDEIDKMRK 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 380 HDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPK-GQYDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRI 458
Cdd:cd17761 121 EDRSALHEAMEQQTISIAKAGIVATLNARAAVLAAANPKfGRFDSYRPVAEQIDLPPTLLSRFDLIFVLKDTPNEEKDRR 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 459 ISSFILE--NKGYPSKSEKLWSMEKMKTYFCLIR-NLQPTLSDVGNQVLLRYYQMQRQS--DCRNAARTTIRLLESLIRL 533
Cdd:cd17761 201 LANHILDthSGGEMREIKPEIDPDLLRKYIAYARkNVRPVLTEEAKQLIKDFYVEMRKSgqETPSPVPITARQLEALVRL 280
|
250 260
....*....|....*....|....*...
gi 1807799447 534 AEAHARLMFRDTVTLEDAITVVSVMESS 561
Cdd:cd17761 281 SEASARMRLSQEVTLEDAERAIRIMLNC 308
|
|
| MCM6 |
cd17757 |
DNA replication licensing factor Mcm6; Mcm6 is a helicase that play an important role in ... |
302-561 |
9.99e-90 |
|
DNA replication licensing factor Mcm6; Mcm6 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.
Pssm-ID: 350663 [Multi-domain] Cd Length: 307 Bit Score: 280.02 E-value: 9.99e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 302 GESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLTVTAVKD--SGEWNLEAGALVLADAGLCCIDEFNSLKE 379
Cdd:cd17757 40 GDINVCIVGDPSTAKSQFLKYVEEFSPRAVYTSGKASSAAGLTAAVVRDeeTGDFVIEAGALMLADNGICCIDEFDKMDI 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 380 HDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNP-KGQYDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRI 458
Cdd:cd17757 120 KDQVAIHEAMEQQTISITKAGIQATLNARTSILAAANPvGGRYDRSKSLKQNINISAPIMSRFDLFFVLLDECNEVTDYA 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 459 ISSFILENKGYPSKS-EKLWSMEKMKTYFCLIRNLQPTLSDVGNQVLLRYYQMQRQSDC----RNAARTTIRLLESLIRL 533
Cdd:cd17757 200 IASHIVDLHSKREEAiEPPFTAEQLKRYIAYARTFKPKLTKEAKDELVEQYKELRQDDAsgstRSSYRITVRQLESLIRL 279
|
250 260
....*....|....*....|....*...
gi 1807799447 534 AEAHARLMFRDTVTLEDAITVVSVMESS 561
Cdd:cd17757 280 SEAIARLHCSDEVTPEHVEEAARLLKKS 307
|
|
| MCM |
pfam00493 |
MCM P-loop domain; |
302-466 |
1.61e-88 |
|
MCM P-loop domain;
Pssm-ID: 459830 [Multi-domain] Cd Length: 224 Bit Score: 273.64 E-value: 1.61e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 302 GESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLTVTAVKD--SGEWNLEAGALVLADAGLCCIDEFNSLKE 379
Cdd:pfam00493 56 GDINVLLVGDPGTAKSQLLKYVEKIAPRAVYTSGKGSSAAGLTAAVVRDpvTGEFVLEAGALVLADGGVCCIDEFDKMND 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 380 HDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPK-GQYDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRI 458
Cdd:pfam00493 136 EDRVALHEAMEQQTISIAKAGIVATLNARCSILAAANPIfGRYDPKKSIAENINLPPPLLSRFDLIFVLLDKPDEEKDER 215
|
....*...
gi 1807799447 459 ISSFILEN 466
Cdd:pfam00493 216 LAKHIVDL 223
|
|
| MCM2 |
cd17753 |
DNA replication licensing factor Mcm2; Mcm2 is a helicase that play an important role in ... |
302-561 |
2.49e-84 |
|
DNA replication licensing factor Mcm2; Mcm2 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.
Pssm-ID: 350659 [Multi-domain] Cd Length: 325 Bit Score: 266.62 E-value: 2.49e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 302 GESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLTVTAVKD--SGEWNLEAGALVLADAGLCCIDEFNSLKE 379
Cdd:cd17753 40 GDINVLLLGDPGTAKSQFLKYVEKTAHRAVFTTGQGASAVGLTASVRKDpvTKEWTLEGGALVLADKGVCLIDEFDKMND 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 380 HDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPK-GQYDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRI 458
Cdd:cd17753 120 QDRTSIHEAMEQQSISISKAGIVTSLQARCSVIAAANPIgGRYNPTLTFAQNVNLTEPILSRFDILCVVRDTVDPEEDER 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 459 ISSFILEN--KGYPSKSEKLWSMEK-------------------MKTYFCLIR-NLQPTLSDVGNQVLLRYY-QMQRQSD 515
Cdd:cd17753 200 LAKFVVGShvRSHPENDEDREGEEEknqrqrpketkvepipqelLRKYIHYAReKVRPKLNQMDMDKVSRVYaDLRKESM 279
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 1807799447 516 CRNAARTTIRLLESLIRLAEAHARLMFRDTVTLEDAITVVSVMESS 561
Cdd:cd17753 280 ATGSLPITVRHLESIIRISEAHAKMHLREYVSEEDVDMAIRVMLDS 325
|
|
| MCM4 |
cd17755 |
DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in ... |
284-561 |
3.36e-84 |
|
DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.
Pssm-ID: 350661 [Multi-domain] Cd Length: 309 Bit Score: 265.84 E-value: 3.36e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 284 VQKEFEDFWEYYKsdpfaGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLTVTAVKD--SGEWNLEAGAL 361
Cdd:cd17755 28 TRKDFTKTGGKYR-----GDINILLCGDPGTSKSQLLQYVHKISPRGVYTSGKGSSAVGLTAYVTRDpdTKQLVLESGAL 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 362 VLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPKG-QYDPQESVSVNIALGSPLLSR 440
Cdd:cd17755 103 VLSDGGICCIDEFDKMSDSTRSVLHEVMEQQTLSIAKAGIITTLNARTSILASANPIGsRYNPKLTVVENIDLPPTLLSR 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 441 FDLILVLLDTKNEDWDRIISSFI----LENKGYPSKSEkLWSMEKMKTYFCLIR-NLQPTLSDVGNQVLLRYYQMQRQ-- 513
Cdd:cd17755 183 FDLIYLVLDKVDEKYDRRLAKHLvslyLEDTPEHIQDE-VLDVEVLTDYISYAReHIHPKLSEEAAQELVQAYVDMRKmg 261
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 1807799447 514 SDCRNAARTTIRLLESLIRLAEAHARLMFRDTVTLEDAITVVSVMESS 561
Cdd:cd17755 262 SDARKRITATPRQLESLIRLAEAHAKMRLSNVVEAEDVEEAVRLIREA 309
|
|
| MCM7 |
cd17758 |
DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in ... |
302-561 |
4.78e-83 |
|
DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.
Pssm-ID: 350664 [Multi-domain] Cd Length: 306 Bit Score: 262.73 E-value: 4.78e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 302 GESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLTVTAVKD--SGEWNLEAGALVLADAGLCCIDEFNSLKE 379
Cdd:cd17758 39 GDINICLMGDPGVAKSQLLKYICRIAPRSVYTTGRGSSGVGLTAAVMKDpvTGEMTLEGGALVLADQGICCIDEFDKMDE 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 380 HDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPK-GQYDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRI 458
Cdd:cd17758 119 SDRTAIHEVMEQQTISIAKAGITTTLNARTSILAAANPAyGRYNPRRSPEQNINLPAALLSRFDLLFLILDKPDRDNDLR 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 459 ISSFIL----ENKGYPSKSEKLwSMEKMKTYFCLIRNLQPTLS-DVGNQVLLRYYQMQRQSDCRN-AARTTIRLLESLIR 532
Cdd:cd17758 199 LAEHVTyvhqHNKQPDSDFEPL-DPKLLRAYIALAKRKRPTVPpALADYIVQAYVEMRQEAKRSKdFTFTTPRTLLAILR 277
|
250 260
....*....|....*....|....*....
gi 1807799447 533 LAEAHARLMFRDTVTLEDAITVVSVMESS 561
Cdd:cd17758 278 LSQALARLRLSDSVEIDDVEEALRLMEMS 306
|
|
| MCM5 |
cd17756 |
DNA replication licensing factor Mcm5; Mcm5 is a helicase that play an important role in ... |
302-551 |
8.76e-74 |
|
DNA replication licensing factor Mcm5; Mcm5 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.
Pssm-ID: 350662 [Multi-domain] Cd Length: 317 Bit Score: 238.82 E-value: 8.76e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 302 GESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLTVTAVKDS--GEWNLEAGALVLADAGLCCIDEFNSLKE 379
Cdd:cd17756 40 GDINVLLLGDPGTAKSQLLKFVEKVAPIGVYTSGKGSSAAGLTASVMRDPstREFYLEGGAMVLADGGVVCIDEFDKMRE 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 380 HDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPK-GQYDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRI 458
Cdd:cd17756 120 DDRVAIHEAMEQQTISIAKAGITTTLNSRTSVLAAANPVfGRYDDLKTPGDNIDFQTTILSRFDMIFIVKDKHDEERDIT 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 459 ISSFILE------NKGYPSKSEKLWSMEKMKTYFCLIR-NLQPTLSDVGNQVLLRYY--------QMQRQSDCRNAARTT 523
Cdd:cd17756 200 IAKHVINihasarKASQSQENEGEIPISKLKRYIAYCRaKCAPRLSEEAAEKLSNHYvtirkdvrQNELESDNRSSIPIT 279
|
250 260
....*....|....*....|....*...
gi 1807799447 524 IRLLESLIRLAEAHARLMFRDTVTLEDA 551
Cdd:cd17756 280 VRQLEAIIRISESLAKMELSPIATEKHV 307
|
|
| MCM3 |
cd17754 |
DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in ... |
302-558 |
1.98e-73 |
|
DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.
Pssm-ID: 350660 [Multi-domain] Cd Length: 299 Bit Score: 237.36 E-value: 1.98e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 302 GESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLT--VTAVKDSGEWNLEAGALVLADAGLCCIDEFNSLKE 379
Cdd:cd17754 40 GDINILLVGDPSVAKSQLLRYVLNTAPLAIATTGRGSSGVGLTaaVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSD 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 380 HDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNP-KGQYDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRI 458
Cdd:cd17754 120 IDRVAIHEVMEQQTVTIAKAGIHASLNARCSVLAAANPvYGRYDVYKTPMENIGLPDSLLSRFDLLFIVLDDIDEERDRS 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 459 ISSFILENKGYpskseklwsMEKMKTYFCLIRNL-QPTLSDVGNQVLLRYYQMQRQSDC--RNAART---TIRLLESLIR 532
Cdd:cd17754 200 ISEHVLRMHRY---------IKFLRKYIHYAKERiKPKLTQEAAEYIAEEYADLRNDDNtkTDKARTspiTARTLETLIR 270
|
250 260
....*....|....*....|....*.
gi 1807799447 533 LAEAHARLMFRDTVTLEDAITVVSVM 558
Cdd:cd17754 271 LATAHAKARLSKTVDKVDAEVALNLL 296
|
|
| MCM8 |
cd17759 |
DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a ... |
299-561 |
1.60e-71 |
|
DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a complex with Mcm9 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).
Pssm-ID: 350665 [Multi-domain] Cd Length: 289 Bit Score: 232.04 E-value: 1.60e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 299 PFAGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLTVTAVKD--SGEWNLEAGALVLADAGLCCIDEFNS 376
Cdd:cd17759 39 PIRGDPHVLIVGDPGLGKSQMLQAACNIAPRGVYVCGNTTTTSGLTVTLTKDgrSGDFALEAGALVLGDQGICGIDEFDK 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 377 L-KEHdrTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPK-GQYDPQESVSVNIALGSPLLSRFDLILVLLDTKNED 454
Cdd:cd17759 119 MgSQH--QALLEAMEQQSVSLAKAGVVCSLPARTSVIAAANPVgGHYNKGKTVSENLKMGPALLSRFDLVFILLDTPSEE 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 455 WDRIISSfilenkgypskseklwSMEKMKTYFCLIR-NLQPTLSDVGNQVLLRYY-QMQRQSDCRNAARTTIRLLESLIR 532
Cdd:cd17759 197 HDHLLSE----------------HHQLLRKYISYARqYVNPVLSKDASEALQEFYlELRKQNQLADSSPITTRQLESLIR 260
|
250 260
....*....|....*....|....*....
gi 1807799447 533 LAEAHARLMFRDTVTLEDAITVVSVMESS 561
Cdd:cd17759 261 LTEARARLELREEATKEDAEDVIEIMKES 289
|
|
| PTZ00111 |
PTZ00111 |
DNA replication licensing factor MCM4; Provisional |
295-561 |
7.80e-56 |
|
DNA replication licensing factor MCM4; Provisional
Pssm-ID: 173403 [Multi-domain] Cd Length: 915 Bit Score: 203.30 E-value: 7.80e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 295 YKSDPFAGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLTVT-AVKDS--GEWNLEAGALVLADAGLCCI 371
Cdd:PTZ00111 484 YKVDNFRGIINVLLCGDPGTAKSQLLHYTHLLSPRSIYTSGKSSSSVGLTASiKFNESdnGRAMIQPGAVVLANGGVCCI 563
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 372 DEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNP-KGQYDPQESVSVNIALGSPLLSRFDLILVLLDT 450
Cdd:PTZ00111 564 DELDKCHNESRLSLYEVMEQQTVTIAKAGIVATLKAETAILASCNPiNSRYNKNKAVIENINISPSLFTRFDLIYLVLDH 643
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 451 KNEDWDRIISSFILENKGYPS---------------------------KSEKLWSMEKMKTY--FCLIrNLQPTLSDVGN 501
Cdd:PTZ00111 644 IDQDTDQLISLSIAKDFLLPHmtgsgndedtydrsntmhvedeslrseKDYNKNDLDMLRMYikFSKL-HCFPKLSDEAK 722
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 502 QVLLRYYQMQRQSD----------------------CRNAART---TIRLLESLIRLAEAHARLMFRDTVTLEDAITVVS 556
Cdd:PTZ00111 723 KVITREYVKMRQGNfqtsnldelehaqedddddlyyQSSGTRMiyvSSRMISSIIRISVSLARMRLSTVVTPADALQAVQ 802
|
....*
gi 1807799447 557 VMESS 561
Cdd:PTZ00111 803 IVKSS 807
|
|
| MCM_OB |
pfam17207 |
MCM OB domain; This family contains an OB-fold found within MCM proteins. This domain contains ... |
116-243 |
6.61e-25 |
|
MCM OB domain; This family contains an OB-fold found within MCM proteins. This domain contains an insertion at the zinc binding motif.
Pssm-ID: 465381 [Multi-domain] Cd Length: 126 Bit Score: 99.86 E-value: 6.61e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 116 KTKDVGHFLSVTGTVIRTSLVK---VLEFerdYMCNKCKHVFVIKadfeqyytFCRPSSCPSlESCDS-SKFTclsgLSS 191
Cdd:pfam17207 6 RSEHIGKLVSVSGIVTRTSEVRpklKKAT---FTCRKCGHTVGVK--------ITEPTKCPN-PECGNkDPFK----LVH 69
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 1807799447 192 SPTRCRDYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGI 243
Cdd:pfam17207 70 EKSKFVDFQKIKIQESPEEVPAGELPRSLDVILDDDLVDRVKPGDRVTVTGI 121
|
|
| MCM_lid |
pfam17855 |
MCM AAA-lid domain; This entry represents the AAA-lid domain found in MCM proteins. |
490-562 |
1.74e-15 |
|
MCM AAA-lid domain; This entry represents the AAA-lid domain found in MCM proteins.
Pssm-ID: 465534 [Multi-domain] Cd Length: 86 Bit Score: 71.81 E-value: 1.74e-15
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1807799447 490 RNLQPTLSDVGNQVLLRYY-QM-QRQSDCRNAARTTIRLLESLIRLAEAHARLMFRDTVTLEDAITVVSVMESSM 562
Cdd:pfam17855 12 EKIKPKLSEEAREKLVDAYvELrKESTGSGSSIPITVRQLESLIRLSEAHAKMRLSEIVTEEDVEEAIRLLKESL 86
|
|
| AAA_5 |
pfam07728 |
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ... |
305-441 |
1.07e-08 |
|
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.
Pssm-ID: 400191 [Multi-domain] Cd Length: 135 Bit Score: 53.84 E-value: 1.07e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 305 HLLLVGDPGTGKSQFLK-YAAKITPRSVLTTGIgstSAGLTVTAVKdsGEWNLEAGALVLADAGL---------CCIDEF 374
Cdd:pfam07728 1 GVLLVGPPGTGKTELAErLAAALSNRPVFYVQL---TRDTTEEDLF--GRRNIDPGGASWVDGPLvraaregeiAVLDEI 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1807799447 375 NSLKEHDRTSIHEAMEQQTISVAKAG-LVCKLNTRTTILAATNPkgqydPQESVSVniaLGSPLLSRF 441
Cdd:pfam07728 76 NRANPDVLNSLLSLLDERRLLLPDGGeLVKAAPDGFRLIATMNP-----LDRGLNE---LSPALRSRF 135
|
|
| AAA |
cd00009 |
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ... |
304-447 |
2.37e-05 |
|
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.
Pssm-ID: 99707 [Multi-domain] Cd Length: 151 Bit Score: 44.83 E-value: 2.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 304 SHLLLVGDPGTGKSQFLKYAAKITPRSVLTTgIGSTSAGLTVTAVKDS--GEWNLEAGALVLADAGLCC--IDEFNSLKE 379
Cdd:cd00009 20 KNLLLYGPPGTGKTTLARAIANELFRPGAPF-LYLNASDLLEGLVVAElfGHFLVRLLFELAEKAKPGVlfIDEIDSLSR 98
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1807799447 380 HDRTSIHEAMEQQTISVakaglvcKLNTRTTILAATNPKGQYDPQEsvsvnialgsPLLSRFDLILVL 447
Cdd:cd00009 99 GAQNALLRVLETLNDLR-------IDRENVRVIGATNRPLLGDLDR----------ALYDRLDIRIVI 149
|
|
| AAA |
smart00382 |
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ... |
305-449 |
9.85e-04 |
|
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.
Pssm-ID: 214640 [Multi-domain] Cd Length: 148 Bit Score: 40.05 E-value: 9.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 305 HLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLTVTAVKDSGEWNLE-----------AGALVLA---DAGLCC 370
Cdd:smart00382 4 VILIVGPPGSGKTTLARALARELGPPGGGVIYIDGEDILEEVLDQLLLIIVGGkkasgsgelrlRLALALArklKPDVLI 83
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1807799447 371 IDEFNSLKEHDRtsiheAMEQQTISVAKAGLVCKLNTRTTILAATNPKGQYDPqesvsvnialgSPLLSRFDLILVLLD 449
Cdd:smart00382 84 LDEITSLLDAEQ-----EALLLLLEELRLLLLLKSEKNLTVILTTNDEKDLGP-----------ALLRRRFDRRIVLLL 146
|
|
| AAA |
pfam00004 |
ATPase family associated with various cellular activities (AAA); AAA family proteins often ... |
306-445 |
7.89e-03 |
|
ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.
Pssm-ID: 459627 [Multi-domain] Cd Length: 130 Bit Score: 36.80 E-value: 7.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799447 306 LLLVGDPGTGKSQFLKYAAKITPRSVLTT---GIGSTSAGLTVTAVKDsgewnleagALVLADAGLCC---IDEFNSL-K 378
Cdd:pfam00004 1 LLLYGPPGTGKTTLAKAVAKELGAPFIEIsgsELVSKYVGESEKRLRE---------LFEAAKKLAPCvifIDEIDALaG 71
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1807799447 379 EHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPKGQYDPqesvsvnialgsPLLSRFDLIL 445
Cdd:pfam00004 72 SRGSGGDSESRRVVNQLLTELDGFTSSNSKVIVIAATNRPDKLDP------------ALLGRFDRII 126
|
|
| |
