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Conserved domains on  [gi|1802776439|ref|NP_001365070|]
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protocadherin Fat 3 isoform 3 precursor [Homo sapiens]

Protein Classification

cadherin repeat domain-containing protein( domain architecture ID 17701464)

cadherin repeat domain-containing protein similar to cadherins, which are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1049-1144 2.90e-34

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 126.66  E-value: 2.90e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439 1049 VGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPL 1128
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                           90
                   ....*....|....*.
gi 1802776439 1129 YSTIEVYIEVEDVNDN 1144
Cdd:cd11304     83 SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 477-574 3.50e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 112.02  E-value: 3.50e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439  477 YDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLN-LLPFVINQFTGVISTTEELDFESSPEiYRFIVRASDWGSP 555
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNeDGLFSIDPSTGEITTAKPLDREEQSS-YTLTVTATDGGGP 80

                           90
                   ....*....|....*....
gi 1802776439  556 yRHESEVNVTIRIGNVNDN 574
Cdd:cd11304     81 -PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 733-827 1.90e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.10  E-value: 1.90e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439  733 VAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKS 812
Cdd:cd11304      4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                           90
                   ....*....|....*
gi 1802776439  813 SWRLLTINVEDANDN 827
Cdd:cd11304     84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 835-931 7.04e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.55  E-value: 7.04e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439  835 SYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVL--TDTQQFAINSSTGIVYVADQLDRESKANYSLKIEARDKAes 912
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG-- 78

                           90
                   ....*....|....*....
gi 1802776439  913 GQQLFSVVTLKVFLDDVND 931
Cdd:cd11304     79 GPPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 162-262 1.07e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.39  E-value: 1.07e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439  162 TYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFK--NKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRgmk 239
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG--- 77

                           90       100
                   ....*....|....*....|...
gi 1802776439  240 lyGNNGVSSTAKLYVHIERINEH 262
Cdd:cd11304     78 --GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 940-1018 1.74e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 98.92  E-value: 1.74e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439  940 SYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLV-NDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRP 1018
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 380-468 1.78e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.12  E-value: 1.78e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439  380 VYDVSISEFSPPGVVVAIVKL----SPEPIDVEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDL- 454
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSAtdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGp 80

                           90
                   ....*....|....*...
gi 1802776439  455 ----KAQVTISIEDANDH 468
Cdd:cd11304     81 plssTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1152-1204 6.48e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 65.80  E-value: 6.48e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1802776439 1152 IYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGW 1204
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGE 53
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 592-672 2.50e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 61.18  E-value: 2.50e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439  592 PVGGHITAVSAIDIDELE--LVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSgiKNGNFALRITATDGEN--LADPMSI 667
Cdd:cd11304     11 PPGTVVLTVSATDPDSGEngEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDRE--EQSSYTLTVTATDGGGppLSSTATV 88


                   ....*
gi 1802776439  668 NISVL 672
Cdd:cd11304     89 TITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 47-153 5.20e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 54.63  E-value: 5.20e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439   47 IYNATVYENSAARTYVnsqsrMGITLIDL----SWDIKYRIVSGDEEGFFkaeeviiadfcflRIRTKGGN---SAILNR 119
Cdd:cd11304      1 SYEVSVPENAPPGTVV-----LTVSATDPdsgeNGEVTYSIVSGNEDGLF-------------SIDPSTGEittAKPLDR 62

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1802776439  120 EIQDNYLLIVKGSVRGED-LEAWTKVNIQVLDMND 153
Cdd:cd11304     63 EEQSSYTLTVTATDGGGPpLSSTATVTITVLDVND 97
CA_like super family cl46864
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 286-357 2.12e-04

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


The actual alignment was detected with superfamily member smart00112:

Pssm-ID: 481204 [Multi-domain]  Cd Length: 81  Bit Score: 41.18  E-value: 2.12e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1802776439   286 TVDDLDDGANGEIeSVSIVAGDPLDQFFLAKEGKWlneykIKERKQIDWESFPYgYNLTLQAKDKGSPQKCS 357
Cdd:smart00112    1 SATDADSGENGKV-TYSILSGNDDGLFSIDPETGE-----ITTTKPLDREEQPE-YTLTVEATDGGGPPLSS 65
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1049-1144 2.90e-34

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 126.66  E-value: 2.90e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439 1049 VGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPL 1128
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                           90
                   ....*....|....*.
gi 1802776439 1129 YSTIEVYIEVEDVNDN 1144
Cdd:cd11304     83 SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 477-574 3.50e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 112.02  E-value: 3.50e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439  477 YDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLN-LLPFVINQFTGVISTTEELDFESSPEiYRFIVRASDWGSP 555
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNeDGLFSIDPSTGEITTAKPLDREEQSS-YTLTVTATDGGGP 80

                           90
                   ....*....|....*....
gi 1802776439  556 yRHESEVNVTIRIGNVNDN 574
Cdd:cd11304     81 -PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 733-827 1.90e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.10  E-value: 1.90e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439  733 VAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKS 812
Cdd:cd11304      4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                           90
                   ....*....|....*
gi 1802776439  813 SWRLLTINVEDANDN 827
Cdd:cd11304     84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 835-931 7.04e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.55  E-value: 7.04e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439  835 SYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVL--TDTQQFAINSSTGIVYVADQLDRESKANYSLKIEARDKAes 912
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG-- 78

                           90
                   ....*....|....*....
gi 1802776439  913 GQQLFSVVTLKVFLDDVND 931
Cdd:cd11304     79 GPPLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1066-1146 7.50e-27

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 104.74  E-value: 7.50e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439  1066 TARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNA 1145
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1802776439  1146 P 1146
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 162-262 1.07e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.39  E-value: 1.07e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439  162 TYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFK--NKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRgmk 239
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG--- 77

                           90       100
                   ....*....|....*....|...
gi 1802776439  240 lyGNNGVSSTAKLYVHIERINEH 262
Cdd:cd11304     78 --GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 940-1018 1.74e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 98.92  E-value: 1.74e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439  940 SYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLV-NDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRP 1018
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80
Cadherin pfam00028
Cadherin domain;
1049-1139 1.08e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 96.22  E-value: 1.08e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439 1049 VGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPL 1128
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPL 81

                           90
                   ....*....|.
gi 1802776439 1129 YSTIEVYIEVE 1139
Cdd:pfam00028   82 SSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 749-829 1.40e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 92.80  E-value: 1.40e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439   749 KAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNS 828
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1802776439   829 P 829
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 495-576 8.91e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.79  E-value: 8.91e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439   495 SASDKDKGENGYITYSIASLN-LLPFVINQFTGVISTTEELDFESSPEiYRFIVRASDWGSPyRHESEVNVTIRIGNVND 573
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNdDGLFSIDPETGEITTTKPLDREEQPE-YTLTVEATDGGGP-PLSSTATVTITVLDVND 78


                    ...
gi 1802776439   574 NSP 576
Cdd:smart00112   79 NAP 81
Cadherin pfam00028
Cadherin domain;
477-568 3.39e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 86.20  E-value: 3.39e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439  477 YDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLP-FVINQFTGVISTTEELDFEsSPEIYRFIVRASDWGSP 555
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGnFRIDPDTGDISTTKPLDRE-SIGEYELTVEATDSGGP 79

                           90
                   ....*....|...
gi 1802776439  556 YRhESEVNVTIRI 568
Cdd:pfam00028   80 PL-SSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 855-934 5.50e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 85.48  E-value: 5.50e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439   855 ARDKDLGSNGEVTYSVL--TDTQQFAINSSTGIVYVADQLDRESKANYSLKIEARDKAesGQQLFSVVTLKVFLDDVNDC 932
Cdd:smart00112    2 ATDADSGENGKVTYSILsgNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGG--GPPLSSTATVTITVLDVNDN 79


                    ..
gi 1802776439   933 SP 934
Cdd:smart00112   80 AP 81
Cadherin pfam00028
Cadherin domain;
941-1018 3.15e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 83.50  E-value: 3.15e-19
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1802776439  941 YSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGR-FEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRP 1018
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGnFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79
Cadherin pfam00028
Cadherin domain;
836-924 1.90e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 81.19  E-value: 1.90e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439  836 YSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDT--QQFAINSSTGIVYVADQLDRESKANYSLKIEARDkaESG 913
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGpgGNFRIDPDTGDISTTKPLDRESIGEYELTVEATD--SGG 78

                           90
                   ....*....|.
gi 1802776439  914 QQLFSVVTLKV 924
Cdd:pfam00028   79 PPLSSTATVTI 89
Cadherin pfam00028
Cadherin domain;
733-822 1.39e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.19  E-value: 1.39e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439  733 VAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKS 812
Cdd:pfam00028    3 ASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLS 82

                           90
                   ....*....|
gi 1802776439  813 SWRLLTINVE 822
Cdd:pfam00028   83 STATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 181-264 1.10e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.15  E-value: 1.10e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439   181 TATDADIGSNGEFYYYFK--NKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKlygnnGVSSTAKLYVHIER 258
Cdd:smart00112    1 SATDADSGENGKVTYSILsgNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-----PLSSTATVTITVLD 75


                    ....*.
gi 1802776439   259 INEHAP 264
Cdd:smart00112   76 VNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 380-468 1.78e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.12  E-value: 1.78e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439  380 VYDVSISEFSPPGVVVAIVKL----SPEPIDVEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDL- 454
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSAtdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGp 80

                           90
                   ....*....|....*...
gi 1802776439  455 ----KAQVTISIEDANDH 468
Cdd:cd11304     81 plssTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
163-257 2.23e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 72.72  E-value: 2.23e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439  163 YSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFK--NKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRgmkl 240
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILggGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS---- 76

                           90
                   ....*....|....*..
gi 1802776439  241 yGNNGVSSTAKLYVHIE 257
Cdd:pfam00028   77 -GGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 961-1018 4.71e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 71.23  E-value: 4.71e-15
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 1802776439   961 HDPDLGLGGQVRYSLV-NDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRP 1018
Cdd:smart00112    3 TDADSGENGKVTYSILsGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP 61
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1152-1204 6.48e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 65.80  E-value: 6.48e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1802776439 1152 IYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGW 1204
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGE 53
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 592-672 2.50e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 61.18  E-value: 2.50e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439  592 PVGGHITAVSAIDIDELE--LVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSgiKNGNFALRITATDGEN--LADPMSI 667
Cdd:cd11304     11 PPGTVVLTVSATDPDSGEngEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDRE--EQSSYTLTVTATDGGGppLSSTATV 88


                   ....*
gi 1802776439  668 NISVL 672
Cdd:cd11304     89 TITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 401-470 3.61e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 60.44  E-value: 3.61e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1802776439   401 SPEPIDVEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLK-----AQVTISIEDANDHTP 470
Cdd:smart00112    7 SGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPplsstATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
1157-1204 8.53e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 56.93  E-value: 8.53e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1802776439 1157 VMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGW 1204
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGD 52
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 47-153 5.20e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 54.63  E-value: 5.20e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439   47 IYNATVYENSAARTYVnsqsrMGITLIDL----SWDIKYRIVSGDEEGFFkaeeviiadfcflRIRTKGGN---SAILNR 119
Cdd:cd11304      1 SYEVSVPENAPPGTVV-----LTVSATDPdsgeNGEVTYSIVSGNEDGLF-------------SIDPSTGEittAKPLDR 62

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1802776439  120 EIQDNYLLIVKGSVRGED-LEAWTKVNIQVLDMND 153
Cdd:cd11304     63 EEQSSYTLTVTATDGGGPpLSSTATVTITVLDVND 97
Cadherin pfam00028
Cadherin domain;
592-672 2.86e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 52.30  E-value: 2.86e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439  592 PVGGHITAVSAIDIDE--LELVKYKIISGNELGFFYLNPDSGVLQLKKSLtnSGIKNGNFALRITATD--GENLADPMSI 667
Cdd:pfam00028   10 PVGTEVLTVTATDPDLgpNGRIFYSILGGGPGGNFRIDPDTGDISTTKPL--DRESIGEYELTVEATDsgGPPLSSTATV 87


                   ....*
gi 1802776439  668 NISVL 672
Cdd:pfam00028   88 TITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 76-156 8.65e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 47.73  E-value: 8.65e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439    76 SWDIKYRIVSGDEEGFFkaeeviiadfcflRIRTKGGN---SAILNREIQDNYLLIVKGSVRGED-LEAWTKVNIQVLDM 151
Cdd:smart00112   10 NGKVTYSILSGNDDGLF-------------SIDPETGEittTKPLDREEQPEYTLTVEATDGGGPpLSSTATVTITVLDV 76


                    ....*
gi 1802776439   152 NDLRP 156
Cdd:smart00112   77 NDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 601-672 3.82e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 46.19  E-value: 3.82e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1802776439   601 SAIDIDELE--LVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSgiKNGNFALRITATDGEN--LADPMSINISVL 672
Cdd:smart00112    1 SATDADSGEngKVTYSILSGNDDGLFSIDPETGEITTTKPLDRE--EQPEYTLTVEATDGGGppLSSTATVTITVL 74
Cadherin pfam00028
Cadherin domain;
381-463 2.95e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 43.83  E-value: 2.95e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439  381 YDVSISEFSPPGVVVAIVKL----SPEPIDVEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLK- 455
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTAtdpdLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPp 80

                           90
                   ....*....|..
gi 1802776439  456 ----AQVTISIE 463
Cdd:pfam00028   81 lsstATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1171-1204 1.32e-04

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 41.57  E-value: 1.32e-04
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1802776439  1171 QAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGW 1204
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGE 34
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 286-357 2.12e-04

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 41.18  E-value: 2.12e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1802776439   286 TVDDLDDGANGEIeSVSIVAGDPLDQFFLAKEGKWlneykIKERKQIDWESFPYgYNLTLQAKDKGSPQKCS 357
Cdd:smart00112    1 SATDADSGENGKV-TYSILSGNDDGLFSIDPETGE-----ITTTKPLDREEQPE-YTLTVEATDGGGPPLSS 65
Cadherin pfam00028
Cadherin domain;
283-353 2.41e-04

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 41.13  E-value: 2.41e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1802776439  283 AVVTVDDLDDGANGEIeSVSIVAGDPLDQFFLAKEGKWlneykIKERKQIDWESFPYgYNLTLQAKDKGSP 353
Cdd:pfam00028   16 LTVTATDPDLGPNGRI-FYSILGGGPGGNFRIDPDTGD-----ISTTKPLDRESIGE-YELTVEATDSGGP 79
Cadherin pfam00028
Cadherin domain;
48-149 2.61e-03

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 38.44  E-value: 2.61e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439   48 YNATVYENSAARTYVNsqsRMGITLIDLS--WDIKYRIVSGDEEGFFkaeeviiadfcflRIRTKGGN---SAILNREIQ 122
Cdd:pfam00028    1 YSASVPENAPVGTEVL---TVTATDPDLGpnGRIFYSILGGGPGGNF-------------RIDPDTGDistTKPLDRESI 64

                           90       100
                   ....*....|....*....|....*...
gi 1802776439  123 DNYLLIVKGSVRGE-DLEAWTKVNIQVL 149
Cdd:pfam00028   65 GEYELTVEATDSGGpPLSSTATVTITVL 92
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1049-1144 2.90e-34

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 126.66  E-value: 2.90e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439 1049 VGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPL 1128
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                           90
                   ....*....|....*.
gi 1802776439 1129 YSTIEVYIEVEDVNDN 1144
Cdd:cd11304     83 SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 477-574 3.50e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 112.02  E-value: 3.50e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439  477 YDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLN-LLPFVINQFTGVISTTEELDFESSPEiYRFIVRASDWGSP 555
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNeDGLFSIDPSTGEITTAKPLDREEQSS-YTLTVTATDGGGP 80

                           90
                   ....*....|....*....
gi 1802776439  556 yRHESEVNVTIRIGNVNDN 574
Cdd:cd11304     81 -PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 733-827 1.90e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.10  E-value: 1.90e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439  733 VAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKS 812
Cdd:cd11304      4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                           90
                   ....*....|....*
gi 1802776439  813 SWRLLTINVEDANDN 827
Cdd:cd11304     84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 835-931 7.04e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.55  E-value: 7.04e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439  835 SYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVL--TDTQQFAINSSTGIVYVADQLDRESKANYSLKIEARDKAes 912
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG-- 78

                           90
                   ....*....|....*....
gi 1802776439  913 GQQLFSVVTLKVFLDDVND 931
Cdd:cd11304     79 GPPLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1066-1146 7.50e-27

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 104.74  E-value: 7.50e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439  1066 TARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNA 1145
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1802776439  1146 P 1146
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 162-262 1.07e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.39  E-value: 1.07e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439  162 TYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFK--NKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRgmk 239
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG--- 77

                           90       100
                   ....*....|....*....|...
gi 1802776439  240 lyGNNGVSSTAKLYVHIERINEH 262
Cdd:cd11304     78 --GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 940-1018 1.74e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 98.92  E-value: 1.74e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439  940 SYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLV-NDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRP 1018
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80
Cadherin pfam00028
Cadherin domain;
1049-1139 1.08e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 96.22  E-value: 1.08e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439 1049 VGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPL 1128
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPL 81

                           90
                   ....*....|.
gi 1802776439 1129 YSTIEVYIEVE 1139
Cdd:pfam00028   82 SSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 749-829 1.40e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 92.80  E-value: 1.40e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439   749 KAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNS 828
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1802776439   829 P 829
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 495-576 8.91e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.79  E-value: 8.91e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439   495 SASDKDKGENGYITYSIASLN-LLPFVINQFTGVISTTEELDFESSPEiYRFIVRASDWGSPyRHESEVNVTIRIGNVND 573
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNdDGLFSIDPETGEITTTKPLDREEQPE-YTLTVEATDGGGP-PLSSTATVTITVLDVND 78


                    ...
gi 1802776439   574 NSP 576
Cdd:smart00112   79 NAP 81
Cadherin pfam00028
Cadherin domain;
477-568 3.39e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 86.20  E-value: 3.39e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439  477 YDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLP-FVINQFTGVISTTEELDFEsSPEIYRFIVRASDWGSP 555
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGnFRIDPDTGDISTTKPLDRE-SIGEYELTVEATDSGGP 79

                           90
                   ....*....|...
gi 1802776439  556 YRhESEVNVTIRI 568
Cdd:pfam00028   80 PL-SSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 855-934 5.50e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 85.48  E-value: 5.50e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439   855 ARDKDLGSNGEVTYSVL--TDTQQFAINSSTGIVYVADQLDRESKANYSLKIEARDKAesGQQLFSVVTLKVFLDDVNDC 932
Cdd:smart00112    2 ATDADSGENGKVTYSILsgNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGG--GPPLSSTATVTITVLDVNDN 79


                    ..
gi 1802776439   933 SP 934
Cdd:smart00112   80 AP 81
Cadherin pfam00028
Cadherin domain;
941-1018 3.15e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 83.50  E-value: 3.15e-19
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1802776439  941 YSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGR-FEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRP 1018
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGnFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79
Cadherin pfam00028
Cadherin domain;
836-924 1.90e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 81.19  E-value: 1.90e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439  836 YSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDT--QQFAINSSTGIVYVADQLDRESKANYSLKIEARDkaESG 913
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGpgGNFRIDPDTGDISTTKPLDRESIGEYELTVEATD--SGG 78

                           90
                   ....*....|.
gi 1802776439  914 QQLFSVVTLKV 924
Cdd:pfam00028   79 PPLSSTATVTI 89
Cadherin pfam00028
Cadherin domain;
733-822 1.39e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.19  E-value: 1.39e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439  733 VAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKS 812
Cdd:pfam00028    3 ASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLS 82

                           90
                   ....*....|
gi 1802776439  813 SWRLLTINVE 822
Cdd:pfam00028   83 STATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 181-264 1.10e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.15  E-value: 1.10e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439   181 TATDADIGSNGEFYYYFK--NKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKlygnnGVSSTAKLYVHIER 258
Cdd:smart00112    1 SATDADSGENGKVTYSILsgNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-----PLSSTATVTITVLD 75


                    ....*.
gi 1802776439   259 INEHAP 264
Cdd:smart00112   76 VNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 380-468 1.78e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.12  E-value: 1.78e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439  380 VYDVSISEFSPPGVVVAIVKL----SPEPIDVEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDL- 454
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSAtdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGp 80

                           90
                   ....*....|....*...
gi 1802776439  455 ----KAQVTISIEDANDH 468
Cdd:cd11304     81 plssTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
163-257 2.23e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 72.72  E-value: 2.23e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439  163 YSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFK--NKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRgmkl 240
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILggGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS---- 76

                           90
                   ....*....|....*..
gi 1802776439  241 yGNNGVSSTAKLYVHIE 257
Cdd:pfam00028   77 -GGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 961-1018 4.71e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 71.23  E-value: 4.71e-15
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 1802776439   961 HDPDLGLGGQVRYSLV-NDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRP 1018
Cdd:smart00112    3 TDADSGENGKVTYSILsGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP 61
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1152-1204 6.48e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 65.80  E-value: 6.48e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1802776439 1152 IYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGW 1204
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGE 53
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 592-672 2.50e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 61.18  E-value: 2.50e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439  592 PVGGHITAVSAIDIDELE--LVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSgiKNGNFALRITATDGEN--LADPMSI 667
Cdd:cd11304     11 PPGTVVLTVSATDPDSGEngEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDRE--EQSSYTLTVTATDGGGppLSSTATV 88


                   ....*
gi 1802776439  668 NISVL 672
Cdd:cd11304     89 TITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 401-470 3.61e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 60.44  E-value: 3.61e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1802776439   401 SPEPIDVEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLK-----AQVTISIEDANDHTP 470
Cdd:smart00112    7 SGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPplsstATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
1157-1204 8.53e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 56.93  E-value: 8.53e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1802776439 1157 VMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGW 1204
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGD 52
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 47-153 5.20e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 54.63  E-value: 5.20e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439   47 IYNATVYENSAARTYVnsqsrMGITLIDL----SWDIKYRIVSGDEEGFFkaeeviiadfcflRIRTKGGN---SAILNR 119
Cdd:cd11304      1 SYEVSVPENAPPGTVV-----LTVSATDPdsgeNGEVTYSIVSGNEDGLF-------------SIDPSTGEittAKPLDR 62

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1802776439  120 EIQDNYLLIVKGSVRGED-LEAWTKVNIQVLDMND 153
Cdd:cd11304     63 EEQSSYTLTVTATDGGGPpLSSTATVTITVLDVND 97
Cadherin pfam00028
Cadherin domain;
592-672 2.86e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 52.30  E-value: 2.86e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439  592 PVGGHITAVSAIDIDE--LELVKYKIISGNELGFFYLNPDSGVLQLKKSLtnSGIKNGNFALRITATD--GENLADPMSI 667
Cdd:pfam00028   10 PVGTEVLTVTATDPDLgpNGRIFYSILGGGPGGNFRIDPDTGDISTTKPL--DRESIGEYELTVEATDsgGPPLSSTATV 87


                   ....*
gi 1802776439  668 NISVL 672
Cdd:pfam00028   88 TITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 76-156 8.65e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 47.73  E-value: 8.65e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439    76 SWDIKYRIVSGDEEGFFkaeeviiadfcflRIRTKGGN---SAILNREIQDNYLLIVKGSVRGED-LEAWTKVNIQVLDM 151
Cdd:smart00112   10 NGKVTYSILSGNDDGLF-------------SIDPETGEittTKPLDREEQPEYTLTVEATDGGGPpLSSTATVTITVLDV 76


                    ....*
gi 1802776439   152 NDLRP 156
Cdd:smart00112   77 NDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 601-672 3.82e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 46.19  E-value: 3.82e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1802776439   601 SAIDIDELE--LVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSgiKNGNFALRITATDGEN--LADPMSINISVL 672
Cdd:smart00112    1 SATDADSGEngKVTYSILSGNDDGLFSIDPETGEITTTKPLDRE--EQPEYTLTVEATDGGGppLSSTATVTITVL 74
Cadherin pfam00028
Cadherin domain;
381-463 2.95e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 43.83  E-value: 2.95e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439  381 YDVSISEFSPPGVVVAIVKL----SPEPIDVEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLK- 455
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTAtdpdLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPp 80

                           90
                   ....*....|..
gi 1802776439  456 ----AQVTISIE 463
Cdd:pfam00028   81 lsstATVTITVL 92
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1050-1144 5.48e-05

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 43.49  E-value: 5.48e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439 1050 GSVKENSRIGTSVLQV-TARDEDSGRDGEIQYSIRDgSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPL 1128
Cdd:cd00031      4 GSAVEGRSRGSFRVSIpTDLIASSGEIIKISAAGKE-ALPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANVP 82

                           90
                   ....*....|....*.
gi 1802776439 1129 YSTIEVYIEVEDVNDN 1144
Cdd:cd00031     83 QTSSVFSIEVYDENDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1171-1204 1.32e-04

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 41.57  E-value: 1.32e-04
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1802776439  1171 QAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGW 1204
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGE 34
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 286-357 2.12e-04

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 41.18  E-value: 2.12e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1802776439   286 TVDDLDDGANGEIeSVSIVAGDPLDQFFLAKEGKWlneykIKERKQIDWESFPYgYNLTLQAKDKGSPQKCS 357
Cdd:smart00112    1 SATDADSGENGKV-TYSILSGNDDGLFSIDPETGE-----ITTTKPLDREEQPE-YTLTVEATDGGGPPLSS 65
Cadherin pfam00028
Cadherin domain;
283-353 2.41e-04

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 41.13  E-value: 2.41e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1802776439  283 AVVTVDDLDDGANGEIeSVSIVAGDPLDQFFLAKEGKWlneykIKERKQIDWESFPYgYNLTLQAKDKGSP 353
Cdd:pfam00028   16 LTVTATDPDLGPNGRI-FYSILGGGPGGNFRIDPDTGD-----ISTTKPLDRESIGE-YELTVEATDSGGP 79
Cadherin_3 pfam16184
Cadherin-like;
1131-1194 9.71e-04

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 39.89  E-value: 9.71e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1802776439 1131 TIEVYIEVEDVNDNAPL--TSEPIYypvVMENSPKDVSVIQIQAEDPDsSSNEKLTYRITSGnPQN 1194
Cdd:pfam16184    4 PFTFNITIIPVNDEAPVltTNTGLR---LWEGSSRPITPDLLQAEDPD-TPPEDLTYTVVQG-PSH 64
Cadherin pfam00028
Cadherin domain;
48-149 2.61e-03

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 38.44  E-value: 2.61e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1802776439   48 YNATVYENSAARTYVNsqsRMGITLIDLS--WDIKYRIVSGDEEGFFkaeeviiadfcflRIRTKGGN---SAILNREIQ 122
Cdd:pfam00028    1 YSASVPENAPVGTEVL---TVTATDPDLGpnGRIFYSILGGGPGGNF-------------RIDPDTGDistTKPLDRESI 64

                           90       100
                   ....*....|....*....|....*...
gi 1802776439  123 DNYLLIVKGSVRGE-DLEAWTKVNIQVL 149
Cdd:pfam00028   65 GEYELTVEATDSGGpPLSSTATVTITVL 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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