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Conserved domains on  [gi|1799133495|ref|NP_001364765|]
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Lon proteolytic domain-containing protein [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lon super family cl33893
ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, ...
 154-240 1.88e-04

ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG0466:

Pssm-ID: 440234 [Multi-domain]  Cd Length: 785  Bit Score: 42.31  E-value: 1.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133495 154 GPS-GV-LATALSVIF---AVKgwsmpHDILVTG--SLGtgGKVEMVGSIKEKVKLARNMNM-TAIVPLGN---LDEVPK 222
Cdd:COG0466   680 GPSaGItMATALVSALtgrPVR-----SDVAMTGeiTLR--GRVLPIGGLKEKLLAAHRAGIkTVILPKENekdLEEIPE 752

                          90       100
                  ....*....|....*....|
gi 1799133495 223 MLKD--EVITVSSLKEAVEI 240
Cdd:COG0466   753 EVKKglEFHPVEHIDEVLKI 772
 
Name Accession Description Interval E-value
Lon COG0466
ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, ...
 154-240 1.88e-04

ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440234 [Multi-domain]  Cd Length: 785  Bit Score: 42.31  E-value: 1.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133495 154 GPS-GV-LATALSVIF---AVKgwsmpHDILVTG--SLGtgGKVEMVGSIKEKVKLARNMNM-TAIVPLGN---LDEVPK 222
Cdd:COG0466   680 GPSaGItMATALVSALtgrPVR-----SDVAMTGeiTLR--GRVLPIGGLKEKLLAAHRAGIkTVILPKENekdLEEIPE 752

                          90       100
                  ....*....|....*....|
gi 1799133495 223 MLKD--EVITVSSLKEAVEI 240
Cdd:COG0466   753 EVKKglEFHPVEHIDEVLKI 772
Lon_C pfam05362
Lon protease (S16) C-terminal proteolytic domain; The Lon serine proteases must hydrolyse ATP ...
 154-240 3.07e-04

Lon protease (S16) C-terminal proteolytic domain; The Lon serine proteases must hydrolyse ATP to degrade protein substrates. In Escherichia coli, these proteases are involved in turnover of intracellular proteins, including abnormal proteins following heat-shock. The active site for protease activity resides in a C-terminal domain. The Lon proteases are classified as family S16 in Merops.


Pssm-ID: 428442 [Multi-domain]  Cd Length: 205  Bit Score: 40.68  E-value: 3.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133495 154 GPSGVLATALSVIFAVKGWSMPHDILVTGSLGTGGKVEMVGSIKEKVKLARNMNM-TAIVPLGN---LDEVPKMLKD--E 227
Cdd:pfam05362 109 GPSAGVTMATALVSALTGIPVRKDVAMTGEITLRGRVLPIGGLKEKLLAAHRAGIkTVIIPKENekdLEDIPENVREglE 188

                          90
                  ....*....|...
gi 1799133495 228 VITVSSLKEAVEI 240
Cdd:pfam05362 189 IIPVEHVDEVLKH 201
 
Name Accession Description Interval E-value
Lon COG0466
ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, ...
 154-240 1.88e-04

ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440234 [Multi-domain]  Cd Length: 785  Bit Score: 42.31  E-value: 1.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133495 154 GPS-GV-LATALSVIF---AVKgwsmpHDILVTG--SLGtgGKVEMVGSIKEKVKLARNMNM-TAIVPLGN---LDEVPK 222
Cdd:COG0466   680 GPSaGItMATALVSALtgrPVR-----SDVAMTGeiTLR--GRVLPIGGLKEKLLAAHRAGIkTVILPKENekdLEEIPE 752

                          90       100
                  ....*....|....*....|
gi 1799133495 223 MLKD--EVITVSSLKEAVEI 240
Cdd:COG0466   753 EVKKglEFHPVEHIDEVLKI 772
Lon_C pfam05362
Lon protease (S16) C-terminal proteolytic domain; The Lon serine proteases must hydrolyse ATP ...
 154-240 3.07e-04

Lon protease (S16) C-terminal proteolytic domain; The Lon serine proteases must hydrolyse ATP to degrade protein substrates. In Escherichia coli, these proteases are involved in turnover of intracellular proteins, including abnormal proteins following heat-shock. The active site for protease activity resides in a C-terminal domain. The Lon proteases are classified as family S16 in Merops.


Pssm-ID: 428442 [Multi-domain]  Cd Length: 205  Bit Score: 40.68  E-value: 3.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133495 154 GPSGVLATALSVIFAVKGWSMPHDILVTGSLGTGGKVEMVGSIKEKVKLARNMNM-TAIVPLGN---LDEVPKMLKD--E 227
Cdd:pfam05362 109 GPSAGVTMATALVSALTGIPVRKDVAMTGEITLRGRVLPIGGLKEKLLAAHRAGIkTVIIPKENekdLEDIPENVREglE 188

                          90
                  ....*....|...
gi 1799133495 228 VITVSSLKEAVEI 240
Cdd:pfam05362 189 IIPVEHVDEVLKH 201
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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