BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133572   5 VQLDVGGTIFKTSKSTLTKF-NGFLKIMLESDIGLKIDESGSIFIDRSPKHFDLILNFMRDGDVVLPSCELTVKELLAEA 83
Cdd:pfam02214   1 VKLNVGGTRFETLKSTLTRFpDTRLGRLLELECDDYDDDTNEYFFDRSPKHFETILNFYRTGGKLHRPEEVCLDEFLEEA 80

                          90
                  ....*....|...
gi 1799133572  84 QFYLLDEL-IELC 95
Cdd:pfam02214  81 EFYGLDELaLELC 93

BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133572   5 VQLDVGGTIFKTSKSTLTKF-NGFLKIMLESDIGLKIDESGSIFIDRSPKHFDLILNFMRDGDVVLPSCELTVKELLAEA 83
Cdd:pfam02214   1 VKLNVGGTRFETLKSTLTRFpDTRLGRLLELECDDYDDDTNEYFFDRSPKHFETILNFYRTGGKLHRPEEVCLDEFLEEA 80

                          90
                  ....*....|...
gi 1799133572  84 QFYLLDEL-IELC 95
Cdd:pfam02214  81 EFYGLDELaLELC 93

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133572    5 VQLDVGGTIFKTSKSTLTKFNGFLKIMLESDIGLKiDESGSIFIDRSPKHFDLILNFMRDGDVVLPscELTVKELLAEAQ 84
Cdd:smart00225   2 VTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKES-DKSEIYLDDVSPEDFRALLNFLYTGKLDLP--EENVEELLELAD 78

                           90
                   ....*....|....*.
gi 1799133572   85 FYLLDELIELCSLKIE 100
Cdd:smart00225  79 YLQIPGLVELCEEFLL 94

BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133572   5 VQLDVGGTIFKTSKSTLTKF-NGFLKIMLESDIGLKIDESGSIFIDRSPKHFDLILNFMRDGDVVLPSCELTVKELLAEA 83
Cdd:pfam02214   1 VKLNVGGTRFETLKSTLTRFpDTRLGRLLELECDDYDDDTNEYFFDRSPKHFETILNFYRTGGKLHRPEEVCLDEFLEEA 80

                          90
                  ....*....|...
gi 1799133572  84 QFYLLDEL-IELC 95
Cdd:pfam02214  81 EFYGLDELaLELC 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD10 (BACURD3), KCTD13 (BACURD1), and TNFAIP1 (BACURD2); This subfamily of KCTD proteins, also called the BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein (BACURD) subfamily, includes KCTD10 (BACURD3), KCTD13 (BACURD1), and TNFAIP1 (BACURD2). KCTD10 is a BTB/POZ domain-containing protein that interacts with proliferating cell nuclear antigen (PCNA) and polymerase delta, and participates in DNA repair, DNA replication, and cell-cycle control. Its down-regulation could inhibit cell proliferation. KCTD10 also plays crucial roles in embryonic angiogenesis and heart development in mammals by negatively regulating the Notch signaling pathway. KCTD13 is a BTB/POZ domain-containing protein that may function as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of RhoA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. TNFAIP1, also called protein B12, is a BTB/POZ domain-containing protein that is involved in DNA replication, DNA damage repair, cell apoptosis, and is implicated in human diseases including cancer, Alzheimer's disease (AD) and type 2 diabetic nephropathy. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD10 and KCTD13 BTB domains form a novel two-fold symmetric tetramer that is distinct from the tetramer formed by voltage-gated potassium (Kv) channels.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133572   5 VQLDVGGTIFKTSKSTLTKFNGFLKIMLESDIGLKIDESGSIFIDRSPKHFDLILNFMRDGDVVLPSCELTVKELLAEAQ 84
Cdd:cd18369     1 VKLNVGGSLHYTTIGTLTKQDTMLRAMFSGRMEVLTDSEGWILIDRCGKHFGTILNYLRDGSVPLPESRRELAELLAEAK 80

                          90
                  ....*....|.
gi 1799133572  85 FYLLDELIELC 95
Cdd:cd18369    81 YYLVQGLVEQC 91

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana FH protein interacting protein FIP2 and similar proteins; FIP2 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133572   5 VQLDVGGTIFKTSKSTLTKFNG-FLKIMLESDIGLKIDESGSIFIDRSPKHFDLILNFMRDGDVVLPSCELTV-KELLAE 82
Cdd:cd18376     1 VKLNVGGQKFTTTLDTLTKDPDsMLAAMFSGRHSLKKDEDGSYFIDRDGTHFRHILNYLRDGEVKIPTEDRSVlKELLEE 80

                  ....*....
gi 1799133572  83 AQFYLLDEL 91
Cdd:cd18376    81 AEYYQLRGL 89

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 10 (KCTD10); KCTD10, also called BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 (BACURD3), is a BTB/POZ domain-containing protein that interacts with proliferating cell nuclear antigen (PCNA) and polymerase delta, and participates in DNA repair, DNA replication, and cell-cycle control. Its down-regulation could inhibit cell proliferation. KCTD10 also plays crucial roles in embryonic angiogenesis and heart development in mammals by negatively regulating the Notch signaling pathway. Furthermore, KCTD10 may function as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD10 BTB domain forms a novel two-fold symmetric tetramer that is distinct from the tetramer formed by voltage-gated potassium (Kv) channels.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133572   2 SETVQLDVGGTIFKTSKSTLTKFNGFLKIMLESDIGLKIDESGSIFIDRSPKHFDLILNFMRDGDVVLPSCELTVKELLA 81
Cdd:cd18399     6 SKYVKLNVGGALYYTTMQTLTKQDTMLKAMFSGRMEVLTDSEGWILIDRCGKHFGTILNYLRDGAVPLPESRREIEELLA 85

                          90
                  ....*....|....*....
gi 1799133572  82 EAQFYLLDELIELCSLKIE 100
Cdd:cd18399    86 EAKYYLVQGLVEECQAALQ 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 9 (KCTD9); KCTD9 is a BTB/POZ domain-containing protein that contributes to liver injury through NK cell activation during hepatitis B virus-induced acute-on-chronic liver failure. It functions as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD9 BTB domain forms a pentameric structure.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133572   5 VQLDVGGTIFKTSKSTLTKF--NGFLKIMLESD--IGLKIDESGSIFIDRSPKHFDLILNFMRDGDVVLPScELTVKELL 80
Cdd:cd18368     3 IKLNVGGRIFTTTRSTLVKKepDSMLARMFSDDstWPSSRDENGAYLIDRSPEYFEPILNYLRHGQLILND-GLNPLGVL 81

                          90
                  ....*....|...
gi 1799133572  81 AEAQFYLLDELIE 93
Cdd:cd18368    82 EEAKFFGIQSLIE 94

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD6, KCTD21 and similar proteins; KCTD6, also called KCASH3 (KCTD containing, Cullin3 adaptor, suppressor of Hedgehog 3), is a substrate-specific adaptor of cullin-3, effectively regulating protein levels of the muscle small ankyrin-1 isoform 5 (sAnk1.5). KCTD21, also called KCASH2, functions as a substrate-specific adaptor of cullin-3, promoting the ubiquitination and degradation of histone deacetylase HDAC1, thereby inhibiting the deacetylation-mediated transcriptional activation of the Hedgehog effectors Gli1 and Gli2. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133572   3 ETVQLDVGGTIFKTSKSTLTKF-NGFLKIMLESDIGLKIDESGSIFIDRSPKHFDLILNFMRDGDVVLPSCELTVKELLA 81
Cdd:cd18365     1 DIVNLNVGGVHYTTTLATLTRFpDSMLGAMFSGSMPTTRDDQGNYFIDRDGTLFRYILNFLRSSQLSLPEDFKEYDLLLR 80

                          90
                  ....*....|..
gi 1799133572  82 EAQFYLLDELIE 93
Cdd:cd18365    81 EADFYQIEPLIE 92

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 6 (KCTD6); KCTD6, also called KCTD containing, Cullin3 adaptor, suppressor of Hedgehog 3 (KCASH3), is a BTB/POZ domain-containing protein that functions as a substrate-specific adaptor of cullin-3, regulating protein levels of the muscle small ankyrin-1 isoform 5 (sAnk1.5) as well as suppressing histone deacetylase and Hedgehog activity in medulloblastoma. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133572   1 MSETVQLDVGGTIFKTSKSTLTKF-NGFLKIMLESDIGLKIDESGSIFIDRSPKHFDLILNFMRDGDVVLPSCELTVKEL 79
Cdd:cd18394     1 MTDPVTLNVGGHLYTTSLSTLTRYpDSMLGAMFRGDFPTARDSQGNYFIDRDGPLFRYILNFLRTSELTLPVDFKEFDLL 80

                          90
                  ....*....|....
gi 1799133572  80 LAEAQFYLLDELIE 93
Cdd:cd18394    81 RKEADFYQIEPLIQ 94

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins KCTD2, KCTD5, and KCTD17, and similar proteins; This subfamily includes potassium channel tetramerization domain-containing proteins KCTD2, KCTD5, and KCTD17, all of which function as adaptors of Cullin3 based ubiquitin E3 ubiquitin ligases. KCTD2 suppresses gliomagenesis by destabilizing c-Myc. KCTD5 is a negative regulator of the AKT pathway, a key signaling cascade frequently deregulated in cancer. KCTD5 does not impact the operation of Kv4.2, Kv3.4, Kv2.1, or Kv1.2 channels. KCTD17 polyubiquitylates trichoplein, a protein involved in ciliogenesis down-regulation. It is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. A missense mutation in KCTD17 causes autosomal dominant myoclonus-dystonia (M-D). The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 and KCTD17 BTB domains form pentamer structures.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133572   5 VQLDVGGTIFKTSKSTLTKF-NGFLKIMLESDIGLKI--DESGSIFIDRSPKHFDLILNFMRDGDVVLPScELTVKELLA 81
Cdd:cd18362     2 VKLNVGGTYFLTTRTTLCRDpKSFLCRLCQEDPDLPSdkDETGAYLIDRDPTYFGPILNYLRHGKLIIDK-DLAEEGVLE 80

                  ....*
gi 1799133572  82 EAQFY 86
Cdd:cd18362    81 EAEFY 85

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 3 (KCTD3); KCTD3, also called renal carcinoma antigen NY-REN-45, is a BTB/POZ domain-containing protein that is an accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3), upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133572   3 ETVQLDVGGTIFKTSKSTLTKF-NGFLKIMLESDIGLKIDESGSIFIDRSPKHFDLILNFMRDGDVVLPSCELTVkeLLA 81
Cdd:cd18392     2 EIIQLNVGGTRFSTSRQTLMWIpDSFFSSLLSGRISSLKDETGAIFIDRDPTAFVPILNFLRTKELDLRGVNINV--LRH 79

                  ....*
gi 1799133572  82 EAQFY 86
Cdd:cd18392    80 EAEFY 84

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 21 (KCTD21); KCTD21, also calledz KCTD containing, Cullin3 adaptor, suppressor of Hedgehog 2 (KCASH2), is a BTB/POZ domain-containing protein that functions as a substrate-specific adaptor of cullin-3, promoting the ubiquitination and degradation of histone deacetylase HDAC1, thereby inhibiting the deacetylation-mediated transcriptional activation of the Hedgehog effectors Gli1 and Gli2. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133572   3 ETVQLDVGGTIFKTSKSTLTKF-NGFLKIMLESDIGLKIDESGSIFIDRSPKHFDLILNFMRDGDVVLPSCELTVKELLA 81
Cdd:cd18395     1 DPITLNVGGKLYTTSLATLTRYpDSMLGAMFSGKFPTKKDSQGNCFIDRDGKIFRYILNFLRTSHLDLPEDFQEMGLLKR 80

                          90
                  ....*....|..
gi 1799133572  82 EAQFYLLDELIE 93
Cdd:cd18395    81 EADFYQIQPLIE 92

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD1 and KCTD15; This subfamily of KCTD proteins includes KCTD1 and KCTD15. KCTD1 is a nuclear BTB/POZ domain-containing protein that acts as a transcriptional repressor and mediates protein-protein interactions through a BTB domain. It represses the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C. It also functions as a novel inhibitor of the Wnt signaling pathway. Mutations in KCTD1 cause scalp-ear-nipple (SEN) syndrome. KCTD15 is a BTB/POZ domain-containing protein that plays a role in the regulation of neural crest (NC) formation and other steps in embryonic development. It inhibits AP2 transcriptional activity by interaction with its activation domain. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD1 BTB domains form pentamers.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133572   5 VQLDVGGTIFKTSKSTLTK---------FNGFLKIMLESdigLKidesGSIFIDRSPKHFDLILNFMRDGDVVLPSCELT 75
Cdd:cd18361     1 VHIDVGGHIYTSSLETLTKypesrlgklFNGSIPIVLDS---LK----QHYFIDRDGKMFRHILNFLRTSKLLLPDDFTE 73

                          90
                  ....*....|....*...
gi 1799133572  76 VKELLAEAQFYLLDELIE 93
Cdd:cd18361    74 FDLLYEEARYYELQPMVK 91

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 5 (KCTD5); KCTD5 is a BTB/POZ domain-containing protein that functions as a substrate adaptor for cullin3 based ubiquitin E3 ligases. It is a negative regulator of the AKT pathway, a key signaling cascade frequently deregulated in cancer. KCTD5 does not impact the operation of Kv4.2, Kv3.4, Kv2.1, or Kv1.2 channels. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 forms pentamers mediated by its BTB domain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133572   2 SETVQLDVGGTIFKTSKSTLTKF-NGFLKIMLESDIGLKID--ESGSIFIDRSPKHFDLILNFMRDGDVVLPScELTVKE 78
Cdd:cd18390     4 SKWVRLNVGGTYFLTTRQTLCRDpKSFLYRLCQADPDLDSDkdETGAYLIDRDPTYFGPVLNYLRHGKLVINK-DLAEEG 82

                          90       100
                  ....*....|....*....|.
gi 1799133572  79 LLAEAQFYLLDELIELCSLKI 99
Cdd:cd18390    83 VLEEAEFYNITSLIKLVKDKI 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein KCTD11; KCTD11 may function as an antagonist of the Hedgehog pathway of cell proliferation and differentiation by affecting the nuclear transfer of transcription factor GLI1, thus maintaining cerebellar granule cells in the undifferentiated state. It is a probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. It contains a BTB/POZ domain; in some cases the domain may be truncated. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. Variants of the human/mouse KCTD11 appear to contain truncated BTB/POZ domains.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133572   5 VQLDVGGTIFKTSKSTLTKF-NGFLKIMLES----DIGLKIDESGSIFIDRSPKHFDLILNFMRDGDVVLPSCELTVKEL 79
Cdd:cd18370     1 VTLNVGGTLYSTTLETLTRFpDSMLGAMFRAgtpiPPNLNMQGGGHYFIDRDGKAFRHILNFLRLGRLDLPRGYGETALL 80

                  ....*..
gi 1799133572  80 LAEAQFY 86
Cdd:cd18370    81 RAEADFY 87

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. This family includes several groups of alpha subunits such as KCNA/Kv1 family of Shaker-type Kv channels, KCNB/Kv2 family of Shab-type Kv channels, KCNC/Kv3 family of Shaw-type Kv channels, KCND/Kv4 family of Shal-type Kv channels, KCNF/Kv5 subfamily of Kv channels, KCNG/Kv6 subfamily of Kv channels, KCNV/Kv8 subfamily of Kv channels, and KCNS/Kv9 subfamily of Kv channels. Kv alpha subunits form functional homo- or hetero-tetrameric channels (typically with other alpha subunits from the same subfamily) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. KCNQ/Kv7 channels are not included in this family, since they do not contain a BTB/POZ domain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133572   5 VQLDVGGTIFKTSKSTLTKF-NGFLKIMLESDIGLkIDESGSIFIDRSPKHFDLILNFMRDGDVVLPSCeLTVKELLAEA 83
Cdd:cd18317     1 VVLNVGGTRFELSRSTLLRFpDTRLGKLAKESHAY-DESTNEYFFDRNPEVFEAILDYYRTGELHLPSN-VCPASFKEEL 78

                  ...
gi 1799133572  84 QFY 86
Cdd:cd18317    79 EFW 81

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 16 (KCTD16); KCTD16 is a BTB/POZ domain-containing protein that is an auxiliary subunit of GABAB receptors associated with mood disorders. It interacts with amyloid beta precursor protein (APP), a type I transmembrane protein involved in a variety of cellular processes such as cell adhesion and axon guidance. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133572   3 ETVQLDVGGTIFKTSKSTLTKF-NGFLKIML----ESDIGLKIDESGSIFIDRSPKHFDLILNFMRDGDVVLPSCELTVK 77
Cdd:cd18398     3 EVVELNVGGQVYFTRHATLVSIpHSLLWKMFspkrDTANDLAKDSKGRFFIDRDGFLFRYILDYLRDRQVVLPDHFPEKG 82

                          90
                  ....*....|....*..
gi 1799133572  78 ELLAEAQFYLLDELIEL 94
Cdd:cd18398    83 RLKREAEYFQLPDLVKL 99

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels and potassium channel tetramerization domain-containing (KCTD) proteins; This family includes two protein groups: voltage-gated potassium (Kv) channels and potassium channel tetramerization domain-containing (KCTD) proteins. Kv channels are membrane proteins with fundamental physiological roles. They are responsible for a variety of electrical phenomena, such as the repolarization of the action potential, spike frequency adaptation, synaptic repolarization, and smooth muscle contraction. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels, and others. All family members contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133572   5 VQLDVGGTIFKTSKSTLTKF-NGFLKIML-ESDIGLKIDESGSIFIDRSPKHFDLILNFMRDGDVVLPScELTVKELLAE 82
Cdd:cd18187     1 VVLNVSGTRFVTNRQTLTRHpDTLLGRMFkPGREFTFPNETGEYFIDRDPTVFRTILNYYRTGKLNCPD-GISIPDLREE 79

                  ....
gi 1799133572  83 AQFY 86
Cdd:cd18187    80 CDFY 83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC1 and KCNC3; KCNC1 (also called NGK2, voltage-gated potassium channel subunit Kv3.1, or voltage-gated potassium channel subunit Kv4) and KCNC3 (also called KSHIIID or voltage-gated potassium channel subunit Kv3.3) play important roles in the rapid repolarization of fast-firing brain neurons. Assuming opened or closed conformations in response to the voltage difference across the membrane, the proteins form tetrameric potassium-selective channels through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNC1 and KCNC3 are alpha subunit that form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133572   2 SETVQLDVGGTIFKTSKSTLTKFNGF-LKIMLESDIGLKID---ESGSIFIDRSPKHFDLILNFMRDGDVVLPS--CELT 75
Cdd:cd18414     2 SDRIVINVGGTRHETYRSTLRTLPGTrLAWLAEPDAHSNFDydpRADEFFFDRHPGVFAHILNYYRTGKLHCPAdvCGPL 81

                          90       100
                  ....*....|....*....|.
gi 1799133572  76 VKELLAeaqFYLLDEL-IELC 95
Cdd:cd18414    82 YEEELA---FWGIDETdVEPC 99

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 2 (KCND2); KCND2, also called voltage-gated potassium channel subunit Kv4.2, is a major pore-forming subunit in somatodendritic subthreshold A-type potassium current I(SA) channels. It mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND2 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133572   5 VQLDVGGTIFKTSKSTLTKFNGFLKIMLESDIGLKiDESGSIFIDRSPKHFDLILNFMRDGDVVLPSCELTVKELLAEAQ 84
Cdd:cd18418     2 IVLNVSGTRFQTWRNTLERYPDTLLGSSERDFFYH-EETQEYFFDRDPDIFRHILNFYRTGKLHYPRHECISAYDEELAF 80

                          90
                  ....*....|.
gi 1799133572  85 FYLLDELIELC 95
Cdd:cd18418    81 FGIIPEIIGDC 91

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCND/Kv4 subfamily of Shal-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv4, also known as subfamily D, contains three alpha subunit members, Kv4.1 (KCND1), Kv4.2 (KCND2), and Kv4.3 (KCND3), which are orthologs of the Shal gene in Drosophila. They are A-type potassium channels that mediate the native, fast inactivating (A-type) K+ current (IA) described both in the nervous system (A currents) and the heart (transient outward current). Kv4/KCND subfamily alpha subunits form functional homo- or hetero-tetrameric channels through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. They are modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133572   7 LDVGGTIFKTSKSTLTKFNGFLKIMLESDIGLKiDESGSIFIDRSPKHFDLILNFMRDGDVVLPSCElTVKELLAEAQFY 86
Cdd:cd18380     4 INVSGRRFETWKNTLEKYPDTLLGSTEKEFFYD-DDTKEYFFDRDPEIFRHILNFYRTGKLHYPRHE-CISAYDDELAFF 81

                          90
                  ....*....|
gi 1799133572  87 -LLDELIELC 95
Cdd:cd18380    82 gILPEIIGDC 91

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 3 (KCND3); KCND3, also called voltage-gated potassium channel subunit Kv4.3, is a pore-forming subunit of voltage-gated rapidly inactivating A-type potassium channels. Mutations in KCND3 cause spinocerebellar ataxia. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND3 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133572   3 ETVQLDVGGTIFKTSKSTLTKFNGFLKIMLESDIGLKiDESGSIFIDRSPKHFDLILNFMRDGDVVLPSCElTVKELLAE 82
Cdd:cd18419    35 ELIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEFFFN-EDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYE-CISAYDEE 112

                          90
                  ....*....|....
gi 1799133572  83 AQFY-LLDELIELC 95
Cdd:cd18419   113 LAFYgILPEIIGDC 126

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133572   5 VQLDVGGTIFKTSKSTLTKFNGFLKIMLESdiglKIDESGSIFI---DRSPKHFDLILNFMRDGDVVlpsCELTVKELLA 81
Cdd:pfam00651  13 VTLVVGDKEFRAHKAVLAACSPYFKALFSG----QESESSVSEItldDVSPEDFEALLEFMYTGKLI---SEENVDDLLA 85

                          90
                  ....*....|....*
gi 1799133572  82 EAQFYLLDELIELCS 96
Cdd:pfam00651  86 AADKLQIPSLVDKCE 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel protein Shaw; Shaw, also called Shaw2, is a voltage-gated potassium channel in Drosophila. It mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shaw is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133572   3 ETVQLDVGGTIFKTSKSTL-----TKFNGFLKIMLESDIGLKidesgSIFIDRSPKHFDLILNFMRDGDVVLPS--CELT 75
Cdd:cd18416     2 NRVVLNVGGIRHETYKATLkkipaTRLSRLTEALANYDPVLN-----EYFFDRHPGVFAQILNYYRTGKLHYPTdvCGPL 76

                          90
                  ....*....|....
gi 1799133572  76 VKEllaEAQFYLLD 89
Cdd:cd18416    77 FEE---ELEFWGLD 87