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Conserved domains on  [gi|1799133391|ref|NP_001364612|]
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PAW domain-containing protein [Caenorhabditis elegans]

Protein Classification

PAW domain-containing protein( domain architecture ID 10652287)

PAW domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAW smart00613
domain present in PNGases and other hypothetical proteins; present in several copies in ...
 252-339 2.11e-29

domain present in PNGases and other hypothetical proteins; present in several copies in proteins with unknown function in C. elegans


:

Pssm-ID: 214745  Cd Length: 89  Bit Score: 109.28  E-value: 2.11e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133391  252 TPGENILDFEYDIVKDKYSQSPENGLFSQVYDVKNIRRIRDTNTNEVYFGLVDGADHGT-ISWRFDKDLNNNKIGRVDIE 330
Cdd:smart00613   1 ESGENYVKFTYDIINDTYSHTNEDGSPVQPYEVKNIERVVDKELNEVYLHKKRPEEEGNyIYWKFDLKSTGKSVEKVVIR 80


                   ....*....
gi 1799133391  331 VRDDEEYSY 339
Cdd:smart00613  81 MSGIEEIAN 89
 
Name Accession Description Interval E-value
PAW smart00613
domain present in PNGases and other hypothetical proteins; present in several copies in ...
 252-339 2.11e-29

domain present in PNGases and other hypothetical proteins; present in several copies in proteins with unknown function in C. elegans


Pssm-ID: 214745  Cd Length: 89  Bit Score: 109.28  E-value: 2.11e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133391  252 TPGENILDFEYDIVKDKYSQSPENGLFSQVYDVKNIRRIRDTNTNEVYFGLVDGADHGT-ISWRFDKDLNNNKIGRVDIE 330
Cdd:smart00613   1 ESGENYVKFTYDIINDTYSHTNEDGSPVQPYEVKNIERVVDKELNEVYLHKKRPEEEGNyIYWKFDLKSTGKSVEKVVIR 80


                   ....*....
gi 1799133391  331 VRDDEEYSY 339
Cdd:smart00613  81 MSGIEEIAN 89
PAW pfam04721
PNGase C-terminal domain, mannose-binding module PAW; The PAW domain is found at the ...
 255-397 3.37e-13

PNGase C-terminal domain, mannose-binding module PAW; The PAW domain is found at the C-terminus of PGNase, or peptide-N-glycanase, enzymes. It was named for 'domain present in PNGases and other worm proteins'. PNGase catalyzes the deglycosylation of several misfolded N-linked glycoproteins by cleaving off the bulky glycan chain before these proteins are degraded by the proteasome. PNGase specifically acts on the unfolded form of high-mannose type N-glycosylated proteins, and this domain appears to be the mannose-binding domain, which contributes to the oligosaccharide-binding specificity of PNGase.


Pssm-ID: 461409  Cd Length: 197  Bit Score: 67.69  E-value: 3.37e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133391 255 ENILDFEYDIVKDKYSQSPEN-----GLFSQVYDVKNIRRIRDTNTNEVYFGLVDGADHGTISWRFDKDLNNNKIGrvDI 329
Cdd:pfam04721  36 AKLFHLRYSIVKDIYTRVSNNnetikGWESGVFSSENIFRKVEHDWKMVYLARTEGTSSGSISWKFDLSSSGLKIK--SI 113

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1799133391 330 EVRDDEEYSYNGKAIATFCIADECWIIRRNSVTSIYDTKHG--QINVIFILTGGD-------AQIFRRSLGEEAHFP 397
Cdd:pfam04721 114 SLKASSQTFESGKVSWRLQSDKTTVEIPGDKTLQSLSSLSGatELTLTAELSGGDgdvawqhAQLFRQSLDDTEEYS 190
 
Name Accession Description Interval E-value
PAW smart00613
domain present in PNGases and other hypothetical proteins; present in several copies in ...
 252-339 2.11e-29

domain present in PNGases and other hypothetical proteins; present in several copies in proteins with unknown function in C. elegans


Pssm-ID: 214745  Cd Length: 89  Bit Score: 109.28  E-value: 2.11e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133391  252 TPGENILDFEYDIVKDKYSQSPENGLFSQVYDVKNIRRIRDTNTNEVYFGLVDGADHGT-ISWRFDKDLNNNKIGRVDIE 330
Cdd:smart00613   1 ESGENYVKFTYDIINDTYSHTNEDGSPVQPYEVKNIERVVDKELNEVYLHKKRPEEEGNyIYWKFDLKSTGKSVEKVVIR 80


                   ....*....
gi 1799133391  331 VRDDEEYSY 339
Cdd:smart00613  81 MSGIEEIAN 89
PAW pfam04721
PNGase C-terminal domain, mannose-binding module PAW; The PAW domain is found at the ...
 255-397 3.37e-13

PNGase C-terminal domain, mannose-binding module PAW; The PAW domain is found at the C-terminus of PGNase, or peptide-N-glycanase, enzymes. It was named for 'domain present in PNGases and other worm proteins'. PNGase catalyzes the deglycosylation of several misfolded N-linked glycoproteins by cleaving off the bulky glycan chain before these proteins are degraded by the proteasome. PNGase specifically acts on the unfolded form of high-mannose type N-glycosylated proteins, and this domain appears to be the mannose-binding domain, which contributes to the oligosaccharide-binding specificity of PNGase.


Pssm-ID: 461409  Cd Length: 197  Bit Score: 67.69  E-value: 3.37e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133391 255 ENILDFEYDIVKDKYSQSPEN-----GLFSQVYDVKNIRRIRDTNTNEVYFGLVDGADHGTISWRFDKDLNNNKIGrvDI 329
Cdd:pfam04721  36 AKLFHLRYSIVKDIYTRVSNNnetikGWESGVFSSENIFRKVEHDWKMVYLARTEGTSSGSISWKFDLSSSGLKIK--SI 113

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1799133391 330 EVRDDEEYSYNGKAIATFCIADECWIIRRNSVTSIYDTKHG--QINVIFILTGGD-------AQIFRRSLGEEAHFP 397
Cdd:pfam04721 114 SLKASSQTFESGKVSWRLQSDKTTVEIPGDKTLQSLSSLSGatELTLTAELSGGDgdvawqhAQLFRQSLDDTEEYS 190
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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