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Conserved domains on  [gi|1799133809|ref|NP_001364588|]
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gluconokinase [Caenorhabditis elegans]

Protein Classification

P-loop NTPase family protein( domain architecture ID 1562424)

P-loop NTPase (nucleoside triphosphate hydrolase) family protein contains two conserved sequence signatures, the Walker A motif (the P-loop proper) and Walker B motif which bind, respectively, the beta and gamma phosphate moieties of the bound nucleotide (typically ATP or GTP), and a Mg(2+) cation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AAA super family cl47477
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 431-545 2.83e-05

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


The actual alignment was detected with superfamily member pfam00004:

Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 44.12  E-value: 2.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133809 431 LLLSGAPDSGKTTWARAISRACHVTHVHIS------KNVVNMGK--RKIYTVVKKLAKqekrLLVSIDRIDVM-KKDPKH 501
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISgselvsKYVGESEKrlRELFEAAKKLAP----CVIFIDEIDALaGSRGSG 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1799133809 502 KGYTHRQIL--LRNFLSDL-SNIKFVMVIGMTRVPlDDLDSYISDLF 545
Cdd:pfam00004  77 GDSESRRVVnqLLTELDGFtSSNSKVIVIAATNRP-DKLDPALLGRF 122
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
 253-278 3.08e-03

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


:

Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 35.60  E-value: 3.08e-03
                          10        20
                  ....*....|....*....|....*.
gi 1799133809 253 TQAAIRIQARTRGYFARKLVREMREK 278
Cdd:cd23767     9 NRAATLIQALWRGYKVRKELKKKKKK 34
 
Name Accession Description Interval E-value
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 431-545 2.83e-05

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 44.12  E-value: 2.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133809 431 LLLSGAPDSGKTTWARAISRACHVTHVHIS------KNVVNMGK--RKIYTVVKKLAKqekrLLVSIDRIDVM-KKDPKH 501
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISgselvsKYVGESEKrlRELFEAAKKLAP----CVIFIDEIDALaGSRGSG 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1799133809 502 KGYTHRQIL--LRNFLSDL-SNIKFVMVIGMTRVPlDDLDSYISDLF 545
Cdd:pfam00004  77 GDSESRRVVnqLLTELDGFtSSNSKVIVIAATNRP-DKLDPALLGRF 122
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 431-539 1.04e-03

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 40.35  E-value: 1.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133809 431 LLLSGAPDSGKTTWARAISRACHVTHVHISKNVVnMGK---------RKIYTVVKKLAkqekRLLVSIDRIDVM--KKDP 499
Cdd:cd19503    37 VLLHGPPGTGKTLLARAVANEAGANFLSISGPSI-VSKylgeseknlREIFEEARSHA----PSIIFIDEIDALapKREE 111

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1799133809 500 KHKGYTHR---QILlrNFLSDLSNIKFVMVIGMTRVPlDDLDS 539
Cdd:cd19503   112 DQREVERRvvaQLL--TLMDGMSSRGKVVVIAATNRP-DAIDP 151
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
 253-278 3.08e-03

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 35.60  E-value: 3.08e-03
                          10        20
                  ....*....|....*....|....*.
gi 1799133809 253 TQAAIRIQARTRGYFARKLVREMREK 278
Cdd:cd23767     9 NRAATLIQALWRGYKVRKELKKKKKK 34
 
Name Accession Description Interval E-value
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 431-545 2.83e-05

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 44.12  E-value: 2.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133809 431 LLLSGAPDSGKTTWARAISRACHVTHVHIS------KNVVNMGK--RKIYTVVKKLAKqekrLLVSIDRIDVM-KKDPKH 501
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISgselvsKYVGESEKrlRELFEAAKKLAP----CVIFIDEIDALaGSRGSG 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1799133809 502 KGYTHRQIL--LRNFLSDL-SNIKFVMVIGMTRVPlDDLDSYISDLF 545
Cdd:pfam00004  77 GDSESRRVVnqLLTELDGFtSSNSKVIVIAATNRP-DKLDPALLGRF 122
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 431-539 1.04e-03

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 40.35  E-value: 1.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133809 431 LLLSGAPDSGKTTWARAISRACHVTHVHISKNVVnMGK---------RKIYTVVKKLAkqekRLLVSIDRIDVM--KKDP 499
Cdd:cd19503    37 VLLHGPPGTGKTLLARAVANEAGANFLSISGPSI-VSKylgeseknlREIFEEARSHA----PSIIFIDEIDALapKREE 111

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1799133809 500 KHKGYTHR---QILlrNFLSDLSNIKFVMVIGMTRVPlDDLDS 539
Cdd:cd19503   112 DQREVERRvvaQLL--TLMDGMSSRGKVVVIAATNRP-DAIDP 151
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
 253-278 3.08e-03

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 35.60  E-value: 3.08e-03
                          10        20
                  ....*....|....*....|....*.
gi 1799133809 253 TQAAIRIQARTRGYFARKLVREMREK 278
Cdd:cd23767     9 NRAATLIQALWRGYKVRKELKKKKKK 34
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
 431-536 3.21e-03

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 38.87  E-value: 3.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133809 431 LLLSGAPDSGKTTWARAISRACHVTHVHISKNVVnMGK-----RKIYTVVKKLAKQEKRLLVSIDRIDVM--KKDPKHKG 503
Cdd:cd19509    35 ILLYGPPGTGKTLLARAVASESGSTFFSISASSL-VSKwvgesEKIVRALFALARELQPSIIFIDEIDSLlsERGSGEHE 113

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1799133809 504 YTHRqilLRN-FLSDL-----SNIKFVMVIGMTRVP--LDD 536
Cdd:cd19509   114 ASRR---VKTeFLVQMdgvlnKPEDRVLVLGATNRPweLDE 151
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 431-539 3.24e-03

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 38.80  E-value: 3.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133809 431 LLLSGAPDSGKTTWARAISRACHVTHVHI------SKNVVNMGK--RKIYtvvkKLAKQEKRLLVSIDRIDVMKKD---P 499
Cdd:cd19481    29 ILLYGPPGTGKTLLAKALAGELGLPLIVVklssllSKYVGESEKnlRKIF----ERARRLAPCILFIDEIDAIGRKrdsS 104

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1799133809 500 KHKGYTHR---QILlrNFLSDLSNIKFVMVIGMTRVPlDDLDS 539
Cdd:cd19481   105 GESGELRRvlnQLL--TELDGVNSRSKVLVIAATNRP-DLLDP 144
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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