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Conserved domains on  [gi|1799133897|ref|NP_001364567|]
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G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

Protein Classification

Srbc family chemoreceptor( domain architecture ID 3435)

Srbc family chemoreceptor belongs to the G-protein coupled receptor (GPCR) superfamily and plays a role in chemoreception

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7TM_GPCR_Srbc super family cl10990
Serpentine type 7TM GPCR chemoreceptor Srbc; Chemoreception is mediated in Caenorhabditis ...
15-251 2.97e-08

Serpentine type 7TM GPCR chemoreceptor Srbc; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srbc is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


The actual alignment was detected with superfamily member pfam10316:

Pssm-ID: 402093  Cd Length: 273  Bit Score: 54.08  E-value: 2.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133897  15 MAMVYLVTDVCCLVAAVLSFCINFFII-TCFLRKKIPCAENLRLALYLAIGDFAYALAALIHVGYLAInwSNTYLDYDPY 93
Cdd:pfam10316   1 MLLIAVIVTLIGIIFSIFTCFLNIYLLkKIFYSKKIKKKPDMVLFYYRFALDVFYGFSVSIYLLYIIL--YSISPEFFVK 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133897  94 VIIFTnSLLPAFLKLVI--VINCSMALDRCLAIFFPVHYRNINKiKFANNA-MALGFIWFLFD--FLFQIFSSEYQRVPN 168
Cdd:pfam10316  79 NLIFY-LGLPSSNIGAIrsILALLISIERVIAVYFPIFYHNYRP-KIPNFIiLILIIAYGLFEqyILFGFCDNVIDIPLN 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133897 169 CATMACFVNKIFLKYLSYSNTLSSFFVAIMSVLVFvgIRKFSKKrvgTFTTRKTSTVFRKANRITAGILFGSLFFVVFPS 248
Cdd:pfam10316 157 CDNFGCAVNQCFFQYWTTHEQIVFSLIVVFSILLS--FKLFIWN---KFKKTQSNKELSKANRLALLDSAIVFLFDFLPS 231

                  ...
gi 1799133897 249 FLV 251
Cdd:pfam10316 232 FIS 234
 
Name Accession Description Interval E-value
7TM_GPCR_Srbc pfam10316
Serpentine type 7TM GPCR chemoreceptor Srbc; Chemoreception is mediated in Caenorhabditis ...
15-251 2.97e-08

Serpentine type 7TM GPCR chemoreceptor Srbc; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srbc is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402093  Cd Length: 273  Bit Score: 54.08  E-value: 2.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133897  15 MAMVYLVTDVCCLVAAVLSFCINFFII-TCFLRKKIPCAENLRLALYLAIGDFAYALAALIHVGYLAInwSNTYLDYDPY 93
Cdd:pfam10316   1 MLLIAVIVTLIGIIFSIFTCFLNIYLLkKIFYSKKIKKKPDMVLFYYRFALDVFYGFSVSIYLLYIIL--YSISPEFFVK 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133897  94 VIIFTnSLLPAFLKLVI--VINCSMALDRCLAIFFPVHYRNINKiKFANNA-MALGFIWFLFD--FLFQIFSSEYQRVPN 168
Cdd:pfam10316  79 NLIFY-LGLPSSNIGAIrsILALLISIERVIAVYFPIFYHNYRP-KIPNFIiLILIIAYGLFEqyILFGFCDNVIDIPLN 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133897 169 CATMACFVNKIFLKYLSYSNTLSSFFVAIMSVLVFvgIRKFSKKrvgTFTTRKTSTVFRKANRITAGILFGSLFFVVFPS 248
Cdd:pfam10316 157 CDNFGCAVNQCFFQYWTTHEQIVFSLIVVFSILLS--FKLFIWN---KFKKTQSNKELSKANRLALLDSAIVFLFDFLPS 231

                  ...
gi 1799133897 249 FLV 251
Cdd:pfam10316 232 FIS 234
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
24-276 1.46e-03

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 39.58  E-value: 1.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133897  24 VCCLVAAVLSFCINFFIITCFLRKKipcaeNLRLALY-----LAIGDFayaLAALIHVGYLAINWSNTYLDYDPYVIIFT 98
Cdd:cd00637     3 VLYILIFVVGLVGNLLVILVILRNR-----RLRTVTNyfilnLAVADL---LVGLLVIPFSLVSLLLGRWWFGDALCKLL 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133897  99 NSLLPAFLKLVIVINCSMALDRCLAIFFPVHYRNINKIKFAnnAMALGFIW---FLFDFLFQIFSSEYQRVPNCATMACF 175
Cdd:cd00637    75 GFLQSVSLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRA--KLLIALIWllsLLLALPPLLGWGVYDYGGYCCCCLCW 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133897 176 VNKIFLKYLSYSNTLSSFFV-----AIMSVLVFVGIRKFSKKRVGTFTTRKTSTVFRKANRITAGILFGSLFFVV--FPS 248
Cdd:cd00637   153 PDLTLSKAYTIFLFVLLFLLpllviIVCYVRIFRKLRRHRRRIRSSSSNSSRRRRRRRERKVTKTLLIVVVVFLLcwLPY 232
                         250       260
                  ....*....|....*....|....*...
gi 1799133897 249 FLVMGFEEVTGKSLFISLGPFYIFSIVV 276
Cdd:cd00637   233 FILLLLDVFGPDPSPLPRILYFLALLLA 260
 
Name Accession Description Interval E-value
7TM_GPCR_Srbc pfam10316
Serpentine type 7TM GPCR chemoreceptor Srbc; Chemoreception is mediated in Caenorhabditis ...
15-251 2.97e-08

Serpentine type 7TM GPCR chemoreceptor Srbc; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srbc is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402093  Cd Length: 273  Bit Score: 54.08  E-value: 2.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133897  15 MAMVYLVTDVCCLVAAVLSFCINFFII-TCFLRKKIPCAENLRLALYLAIGDFAYALAALIHVGYLAInwSNTYLDYDPY 93
Cdd:pfam10316   1 MLLIAVIVTLIGIIFSIFTCFLNIYLLkKIFYSKKIKKKPDMVLFYYRFALDVFYGFSVSIYLLYIIL--YSISPEFFVK 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133897  94 VIIFTnSLLPAFLKLVI--VINCSMALDRCLAIFFPVHYRNINKiKFANNA-MALGFIWFLFD--FLFQIFSSEYQRVPN 168
Cdd:pfam10316  79 NLIFY-LGLPSSNIGAIrsILALLISIERVIAVYFPIFYHNYRP-KIPNFIiLILIIAYGLFEqyILFGFCDNVIDIPLN 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133897 169 CATMACFVNKIFLKYLSYSNTLSSFFVAIMSVLVFvgIRKFSKKrvgTFTTRKTSTVFRKANRITAGILFGSLFFVVFPS 248
Cdd:pfam10316 157 CDNFGCAVNQCFFQYWTTHEQIVFSLIVVFSILLS--FKLFIWN---KFKKTQSNKELSKANRLALLDSAIVFLFDFLPS 231

                  ...
gi 1799133897 249 FLV 251
Cdd:pfam10316 232 FIS 234
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
24-276 1.46e-03

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 39.58  E-value: 1.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133897  24 VCCLVAAVLSFCINFFIITCFLRKKipcaeNLRLALY-----LAIGDFayaLAALIHVGYLAINWSNTYLDYDPYVIIFT 98
Cdd:cd00637     3 VLYILIFVVGLVGNLLVILVILRNR-----RLRTVTNyfilnLAVADL---LVGLLVIPFSLVSLLLGRWWFGDALCKLL 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133897  99 NSLLPAFLKLVIVINCSMALDRCLAIFFPVHYRNINKIKFAnnAMALGFIW---FLFDFLFQIFSSEYQRVPNCATMACF 175
Cdd:cd00637    75 GFLQSVSLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRA--KLLIALIWllsLLLALPPLLGWGVYDYGGYCCCCLCW 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133897 176 VNKIFLKYLSYSNTLSSFFV-----AIMSVLVFVGIRKFSKKRVGTFTTRKTSTVFRKANRITAGILFGSLFFVV--FPS 248
Cdd:cd00637   153 PDLTLSKAYTIFLFVLLFLLpllviIVCYVRIFRKLRRHRRRIRSSSSNSSRRRRRRRERKVTKTLLIVVVVFLLcwLPY 232
                         250       260
                  ....*....|....*....|....*...
gi 1799133897 249 FLVMGFEEVTGKSLFISLGPFYIFSIVV 276
Cdd:cd00637   233 FILLLLDVFGPDPSPLPRILYFLALLLA 260
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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