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Conserved domains on  [gi|1797616742|ref|NP_001364418|]
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zinc finger B-box domain-containing protein 1 isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Bbox1_ZBBX cd19818
B-box-type 1 zinc finger found in zinc finger B-box domain-containing protein 1 (ZBBX) and ...
 133-175 1.92e-24

B-box-type 1 zinc finger found in zinc finger B-box domain-containing protein 1 (ZBBX) and similar proteins; The family corresponds to a group of uncharacterized zinc finger B-box domain-containing proteins. The B-box motif shows high sequence similarity with B-Box-type 1 zinc finger found in tripartite motif-containing proteins (TRIMs). The type 1 B-box (Bbox1) zinc finger is characterized by a C6H2 zinc-binding consensus motif.


:

Pssm-ID: 380876  Cd Length: 43  Bit Score: 96.28  E-value: 1.92e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1797616742 133 VCGQCENKAALLVCLECGEDYCSGCFAKVHQKGALKLHRTTLL 175
Cdd:cd19818     1 QCGQCEQKAALLVCLECGEDYCSSCFAKFHQKGALKKHRSIPL 43
 
Name Accession Description Interval E-value
Bbox1_ZBBX cd19818
B-box-type 1 zinc finger found in zinc finger B-box domain-containing protein 1 (ZBBX) and ...
 133-175 1.92e-24

B-box-type 1 zinc finger found in zinc finger B-box domain-containing protein 1 (ZBBX) and similar proteins; The family corresponds to a group of uncharacterized zinc finger B-box domain-containing proteins. The B-box motif shows high sequence similarity with B-Box-type 1 zinc finger found in tripartite motif-containing proteins (TRIMs). The type 1 B-box (Bbox1) zinc finger is characterized by a C6H2 zinc-binding consensus motif.


Pssm-ID: 380876  Cd Length: 43  Bit Score: 96.28  E-value: 1.92e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1797616742 133 VCGQCENKAALLVCLECGEDYCSGCFAKVHQKGALKLHRTTLL 175
Cdd:cd19818     1 QCGQCEQKAALLVCLECGEDYCSSCFAKFHQKGALKKHRSIPL 43
BBOX smart00336
B-Box-type zinc finger;
133-175 4.70e-04

B-Box-type zinc finger;


Pssm-ID: 197662 [Multi-domain]  Cd Length: 42  Bit Score: 38.47  E-value: 4.70e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1797616742  133 VCGQCENKAALLVCLECGEDYCSGCFAKVHQKgalklHRTTLL 175
Cdd:smart00336   5 KCDSHGDEPAEFFCEECGALLCRTCDEAEHRG-----HTVVLL 42
zf-B_box pfam00643
B-box zinc finger;
132-175 1.86e-03

B-box zinc finger;


Pssm-ID: 459886 [Multi-domain]  Cd Length: 42  Bit Score: 36.68  E-value: 1.86e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1797616742 132 KVCGQCENKAALLVCLECGEDYCSGCFAKVHQKgalklHRTTLL 175
Cdd:pfam00643   4 RLCPEHEEEPLTLYCNDCQELLCEECSVGEHRG-----HTVVPL 42
 
Name Accession Description Interval E-value
Bbox1_ZBBX cd19818
B-box-type 1 zinc finger found in zinc finger B-box domain-containing protein 1 (ZBBX) and ...
 133-175 1.92e-24

B-box-type 1 zinc finger found in zinc finger B-box domain-containing protein 1 (ZBBX) and similar proteins; The family corresponds to a group of uncharacterized zinc finger B-box domain-containing proteins. The B-box motif shows high sequence similarity with B-Box-type 1 zinc finger found in tripartite motif-containing proteins (TRIMs). The type 1 B-box (Bbox1) zinc finger is characterized by a C6H2 zinc-binding consensus motif.


Pssm-ID: 380876  Cd Length: 43  Bit Score: 96.28  E-value: 1.92e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1797616742 133 VCGQCENKAALLVCLECGEDYCSGCFAKVHQKGALKLHRTTLL 175
Cdd:cd19818     1 QCGQCEQKAALLVCLECGEDYCSSCFAKFHQKGALKKHRSIPL 43
Bbox1 cd19757
B-box-type 1 zinc finger (Bbox1); The B-box-type zinc finger is a short zinc binding domain of ...
 133-175 1.76e-09

B-box-type 1 zinc finger (Bbox1); The B-box-type zinc finger is a short zinc binding domain of around 40 amino acid residues in length. It has been found in transcription factors, ribonucleoproteins and proto-oncoproteins, such as in TRIM (tripartite motif) proteins that consist of an N-terminal RING finger (originally called an A-box), followed by 1-2 B-box domains and a coiled-coil domain (also called RBCC for Ring, B-box, Coiled-Coil). The B-box-type zinc finger often presents in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain, in functionally unrelated proteins, most likely mediating protein-protein interactions. Based on different consensus sequences and the spacing of the 7-8 zinc-binding residues, the B-box-type zinc fingers can be divided into two groups, type 1 (Bbox1: C6H2) and type 2 (Bbox2: CHC3H2). This family corresponds to the type 1 B-box (Bbox1).


Pssm-ID: 380815 [Multi-domain]  Cd Length: 44  Bit Score: 53.65  E-value: 1.76e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1797616742 133 VCGQCENKAALLVCLECGEDYCSGCFAKVHQKG-ALKLHRTTLL 175
Cdd:cd19757     1 LCDECEEREATVYCLECEEFLCDDCSDAIHRRGkLTRSHKLVPL 44
Bbox1_DUF2009 cd20208
B-box-type 1 zinc finger found in DUF2009 domain-containing proteins and similar proteins; ...
 133-173 2.83e-07

B-box-type 1 zinc finger found in DUF2009 domain-containing proteins and similar proteins; This group is composed of uncharacterized proteins containing a zinc finger B-box domain and a DUF2009 domain, and similar zinc finger B-box domain-containing proteins. The B-box motif shows high sequence similarity with B-Box-type 1 zinc finger found in tripartite motif-containing proteins (TRIMs). The type 1 B-box (Bbox1) zinc finger is characterized by a C6H2 zinc-binding consensus motif.


Pssm-ID: 380909 [Multi-domain]  Cd Length: 43  Bit Score: 47.37  E-value: 2.83e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1797616742 133 VCGQCENKAALLVCLECGEDYCSGCFAKVHQKGALKLHRTT 173
Cdd:cd20208     1 MCIECEDQPAEVRCEECGDEFCEVCFQSQHRKGKRRLHSFR 41
BBOX smart00336
B-Box-type zinc finger;
133-175 4.70e-04

B-Box-type zinc finger;


Pssm-ID: 197662 [Multi-domain]  Cd Length: 42  Bit Score: 38.47  E-value: 4.70e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1797616742  133 VCGQCENKAALLVCLECGEDYCSGCFAKVHQKgalklHRTTLL 175
Cdd:smart00336   5 KCDSHGDEPAEFFCEECGALLCRTCDEAEHRG-----HTVVLL 42
zf-B_box pfam00643
B-box zinc finger;
132-175 1.86e-03

B-box zinc finger;


Pssm-ID: 459886 [Multi-domain]  Cd Length: 42  Bit Score: 36.68  E-value: 1.86e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1797616742 132 KVCGQCENKAALLVCLECGEDYCSGCFAKVHQKgalklHRTTLL 175
Cdd:pfam00643   4 RLCPEHEEEPLTLYCNDCQELLCEECSVGEHRG-----HTVVPL 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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