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Conserved domains on  [gi|1770726288|ref|NP_001362439|]
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microtubule-associated protein 2 isoform 20 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MAP2_projctn super family cl25763
MAP2/Tau projection domain; This domain is found in the MAP2/Tau family of proteins which ...
151-263 3.08e-67

MAP2/Tau projection domain; This domain is found in the MAP2/Tau family of proteins which includes MAP2, MAP4, Tau, and their homologs. All isoforms contain a conserved C-terminal domain containing tubulin-binding repeats (pfam00418), and a N-terminal projection domain of varying size. This domain has a net negative charge and exerts a long-range repulsive force. This provides a mechanism that can regulate microtubule spacing which might facilitate efficient organelle transport.


The actual alignment was detected with superfamily member pfam08377:

Pssm-ID: 429957 [Multi-domain]  Cd Length: 1134  Bit Score: 236.86  E-value: 3.08e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726288  151 EDDDRSIMTEQLETIPKEEKAEKEARRSSLEKHRKEKPFKTGRGRISTPERKVAKKEPSTVSRDEVRRKKAVYKKAELAK 230
Cdd:pfam08377 1022 QDDDRSIMTEQLETIPKEEKAEKEARRPSLEKHRKEKPFKTGRGRISTPERKVAKKEPSTVSRDEVRRKKAVYKKAELAK 1101
                           90       100       110
                   ....*....|....*....|....*....|...
gi 1770726288  231 KTEVQAHSPSRKFILKPAIKYTRPTHLSCVKRK 263
Cdd:pfam08377 1102 KTEVQAHSPSRKFILKPAIKYTRPTHLSCVKRK 1134
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
450-479 7.50e-12

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 59.73  E-value: 7.50e-12
                          10        20        30
                  ....*....|....*....|....*....|
gi 1770726288 450 VQIVTKKIDLSHVTSKCGSLKNIRHRPGGG 479
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
481-511 2.64e-11

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 58.19  E-value: 2.64e-11
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1770726288 481 VKIESVKLDFKeKAQAKVGSLDNAHHVPGGG 511
Cdd:pfam00418   1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
419-448 3.06e-07

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 46.64  E-value: 3.06e-07
                          10        20        30
                  ....*....|....*....|....*....|
gi 1770726288 419 RLINQPLpDLKNVKSKIGSTDNIKYQPKGG 448
Cdd:pfam00418   2 KIESKKL-DFSKVQSKCGSKDNIKHKPGGG 30
PTZ00449 super family cl33186
104 kDa microneme/rhoptry antigen; Provisional
206-446 2.28e-04

104 kDa microneme/rhoptry antigen; Provisional


The actual alignment was detected with superfamily member PTZ00449:

Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 44.30  E-value: 2.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726288 206 KEPSTVSRDEVRRKK-AVYKKAELAKKT-EVQAHSPSRKFIL--KPAIKyTRPTHLSCVKRKTTAAGGESALAPSVFKQA 281
Cdd:PTZ00449  534 HEDSKESDEPKEGGKpGETKEGEVGKKPgPAKEHKPSKIPTLskKPEFP-KDPKHPKDPEEPKKPKRPRSAQRPTRPKSP 612
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726288 282 KDKVSDGVTKSPEKRSSLPRPSSILPPRRGVSGDRDENSFSLNSSISSSA------------------RRTTRS-EPIRR 342
Cdd:PTZ00449  613 KLPELLDIPKSPKRPESPKSPKRPPPPQRPSSPERPEGPKIIKSPKPPKSpkppfdpkfkekfyddylDAAAKSkETKTT 692
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726288 343 AGKSGTSTPTTPGSTAITPGTPPSYSSRTPgtPGTPSYPRTPHTP-GTPKSAILVPSEkkvaiIRTPPKSPATPKQLRLI 421
Cdd:PTZ00449  693 VVLDESFESILKETLPETPGTPFTTPRPLP--PKLPRDEEFPFEPiGDPDAEQPDDIE-----FFTPPEEERTFFHETPA 765
                         250       260       270
                  ....*....|....*....|....*....|..
gi 1770726288 422 NQPLPDL-------KNVKSKIGSTDNIKYQPK 446
Cdd:PTZ00449  766 DTPLPDIlaeefkeEDIHAETGEPDEAMKRPD 797
 
Name Accession Description Interval E-value
MAP2_projctn pfam08377
MAP2/Tau projection domain; This domain is found in the MAP2/Tau family of proteins which ...
151-263 3.08e-67

MAP2/Tau projection domain; This domain is found in the MAP2/Tau family of proteins which includes MAP2, MAP4, Tau, and their homologs. All isoforms contain a conserved C-terminal domain containing tubulin-binding repeats (pfam00418), and a N-terminal projection domain of varying size. This domain has a net negative charge and exerts a long-range repulsive force. This provides a mechanism that can regulate microtubule spacing which might facilitate efficient organelle transport.


Pssm-ID: 429957 [Multi-domain]  Cd Length: 1134  Bit Score: 236.86  E-value: 3.08e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726288  151 EDDDRSIMTEQLETIPKEEKAEKEARRSSLEKHRKEKPFKTGRGRISTPERKVAKKEPSTVSRDEVRRKKAVYKKAELAK 230
Cdd:pfam08377 1022 QDDDRSIMTEQLETIPKEEKAEKEARRPSLEKHRKEKPFKTGRGRISTPERKVAKKEPSTVSRDEVRRKKAVYKKAELAK 1101
                           90       100       110
                   ....*....|....*....|....*....|...
gi 1770726288  231 KTEVQAHSPSRKFILKPAIKYTRPTHLSCVKRK 263
Cdd:pfam08377 1102 KTEVQAHSPSRKFILKPAIKYTRPTHLSCVKRK 1134
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
450-479 7.50e-12

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 59.73  E-value: 7.50e-12
                          10        20        30
                  ....*....|....*....|....*....|
gi 1770726288 450 VQIVTKKIDLSHVTSKCGSLKNIRHRPGGG 479
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
481-511 2.64e-11

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 58.19  E-value: 2.64e-11
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1770726288 481 VKIESVKLDFKeKAQAKVGSLDNAHHVPGGG 511
Cdd:pfam00418   1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
419-448 3.06e-07

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 46.64  E-value: 3.06e-07
                          10        20        30
                  ....*....|....*....|....*....|
gi 1770726288 419 RLINQPLpDLKNVKSKIGSTDNIKYQPKGG 448
Cdd:pfam00418   2 KIESKKL-DFSKVQSKCGSKDNIKHKPGGG 30
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
206-446 2.28e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 44.30  E-value: 2.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726288 206 KEPSTVSRDEVRRKK-AVYKKAELAKKT-EVQAHSPSRKFIL--KPAIKyTRPTHLSCVKRKTTAAGGESALAPSVFKQA 281
Cdd:PTZ00449  534 HEDSKESDEPKEGGKpGETKEGEVGKKPgPAKEHKPSKIPTLskKPEFP-KDPKHPKDPEEPKKPKRPRSAQRPTRPKSP 612
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726288 282 KDKVSDGVTKSPEKRSSLPRPSSILPPRRGVSGDRDENSFSLNSSISSSA------------------RRTTRS-EPIRR 342
Cdd:PTZ00449  613 KLPELLDIPKSPKRPESPKSPKRPPPPQRPSSPERPEGPKIIKSPKPPKSpkppfdpkfkekfyddylDAAAKSkETKTT 692
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726288 343 AGKSGTSTPTTPGSTAITPGTPPSYSSRTPgtPGTPSYPRTPHTP-GTPKSAILVPSEkkvaiIRTPPKSPATPKQLRLI 421
Cdd:PTZ00449  693 VVLDESFESILKETLPETPGTPFTTPRPLP--PKLPRDEEFPFEPiGDPDAEQPDDIE-----FFTPPEEERTFFHETPA 765
                         250       260       270
                  ....*....|....*....|....*....|..
gi 1770726288 422 NQPLPDL-------KNVKSKIGSTDNIKYQPK 446
Cdd:PTZ00449  766 DTPLPDIlaeefkeEDIHAETGEPDEAMKRPD 797
 
Name Accession Description Interval E-value
MAP2_projctn pfam08377
MAP2/Tau projection domain; This domain is found in the MAP2/Tau family of proteins which ...
151-263 3.08e-67

MAP2/Tau projection domain; This domain is found in the MAP2/Tau family of proteins which includes MAP2, MAP4, Tau, and their homologs. All isoforms contain a conserved C-terminal domain containing tubulin-binding repeats (pfam00418), and a N-terminal projection domain of varying size. This domain has a net negative charge and exerts a long-range repulsive force. This provides a mechanism that can regulate microtubule spacing which might facilitate efficient organelle transport.


Pssm-ID: 429957 [Multi-domain]  Cd Length: 1134  Bit Score: 236.86  E-value: 3.08e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726288  151 EDDDRSIMTEQLETIPKEEKAEKEARRSSLEKHRKEKPFKTGRGRISTPERKVAKKEPSTVSRDEVRRKKAVYKKAELAK 230
Cdd:pfam08377 1022 QDDDRSIMTEQLETIPKEEKAEKEARRPSLEKHRKEKPFKTGRGRISTPERKVAKKEPSTVSRDEVRRKKAVYKKAELAK 1101
                           90       100       110
                   ....*....|....*....|....*....|...
gi 1770726288  231 KTEVQAHSPSRKFILKPAIKYTRPTHLSCVKRK 263
Cdd:pfam08377 1102 KTEVQAHSPSRKFILKPAIKYTRPTHLSCVKRK 1134
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
450-479 7.50e-12

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 59.73  E-value: 7.50e-12
                          10        20        30
                  ....*....|....*....|....*....|
gi 1770726288 450 VQIVTKKIDLSHVTSKCGSLKNIRHRPGGG 479
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
481-511 2.64e-11

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 58.19  E-value: 2.64e-11
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1770726288 481 VKIESVKLDFKeKAQAKVGSLDNAHHVPGGG 511
Cdd:pfam00418   1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
419-448 3.06e-07

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 46.64  E-value: 3.06e-07
                          10        20        30
                  ....*....|....*....|....*....|
gi 1770726288 419 RLINQPLpDLKNVKSKIGSTDNIKYQPKGG 448
Cdd:pfam00418   2 KIESKKL-DFSKVQSKCGSKDNIKHKPGGG 30
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
206-446 2.28e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 44.30  E-value: 2.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726288 206 KEPSTVSRDEVRRKK-AVYKKAELAKKT-EVQAHSPSRKFIL--KPAIKyTRPTHLSCVKRKTTAAGGESALAPSVFKQA 281
Cdd:PTZ00449  534 HEDSKESDEPKEGGKpGETKEGEVGKKPgPAKEHKPSKIPTLskKPEFP-KDPKHPKDPEEPKKPKRPRSAQRPTRPKSP 612
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726288 282 KDKVSDGVTKSPEKRSSLPRPSSILPPRRGVSGDRDENSFSLNSSISSSA------------------RRTTRS-EPIRR 342
Cdd:PTZ00449  613 KLPELLDIPKSPKRPESPKSPKRPPPPQRPSSPERPEGPKIIKSPKPPKSpkppfdpkfkekfyddylDAAAKSkETKTT 692
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726288 343 AGKSGTSTPTTPGSTAITPGTPPSYSSRTPgtPGTPSYPRTPHTP-GTPKSAILVPSEkkvaiIRTPPKSPATPKQLRLI 421
Cdd:PTZ00449  693 VVLDESFESILKETLPETPGTPFTTPRPLP--PKLPRDEEFPFEPiGDPDAEQPDDIE-----FFTPPEEERTFFHETPA 765
                         250       260       270
                  ....*....|....*....|....*....|..
gi 1770726288 422 NQPLPDL-------KNVKSKIGSTDNIKYQPK 446
Cdd:PTZ00449  766 DTPLPDIlaeefkeEDIHAETGEPDEAMKRPD 797
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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