NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1770726429|ref|NP_001362408|]
View 

probable E3 ubiquitin-protein ligase HERC3 isoform 5 [Homo sapiens]

Protein Classification

E3 ubiquitin-protein ligase HERC family protein( domain architecture ID 18806229)

E3 ubiquitin-protein ligase HERC (HECT and RCC1 domain) family protein similar to human E3 ISG15--protein ligase HERC5, the major E3 ligase for ISG15 conjugation, that functions as part of the ISGylation machinery that recognizes target proteins in a broad and relatively non-specific manner

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
HECTc cd00078
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ...
 694-1040 1.18e-139

HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.


:

Pssm-ID: 238033 [Multi-domain]  Cd Length: 352  Bit Score: 423.13  E-value: 1.18e-139
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429  694 LVLHVRRNNLVGDALRELSIHSDIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMFTYYQDS-NLLWFSDT 772
Cdd:cd00078      1 LKITVRRDRILEDALRQLSKVSSSDLKKVLEVEFVGEEGIDAGGVTREFFTLVSKELFNPSYGLFRYTPDDsGLLYPNPS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429  773 CFV---EHNWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSPTEGRSLQELLDYPGEdvEETFCLNF 849
Cdd:cd00078     81 SFAdedHLKLFRFLGRLLGKALYEGRLLDLPFSRAFYKKLLGKPLSLEDLEELDPELYKSLKELLDNDGD--EDDLELTF 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429  850 TICR-ESYGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVG 928
Cdd:cd00078    159 TIELdSSFGGAVTVELKPGGRDIPVTNENKEEYVDLYVDYRLNKGIEEQVEAFRDGFSEVIPEELLSLFTPEELELLICG 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429  929 NSNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASLQ--IVIQSTASGEEYLPV 1006
Cdd:cd00078    239 SEDIDLEDLKKNTEYKGGYSSDSPTIQWFWEVLESFTNEERKKFLQFVTGSSRLPVGGFADLNpkFTIRRVGSPDDRLPT 318

                          330       340       350
                   ....*....|....*....|....*....|....
gi 1770726429 1007 AHTCYNLLDLPKYSSKEILSARLTQALDNYEGFS 1040
Cdd:cd00078    319 AHTCFNLLKLPPYSSKEILREKLLYAINEGAGFG 352
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 3-341 1.92e-79

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


:

Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 262.99  E-value: 1.92e-79
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429    3 CWGYWSLGQPGISTNLQGIVAEpQVCGFisdRSVKEVACGGNHSVFLLEDGEVYTCGLNTKGQLG--HEREGNKPEQIGA 80
Cdd:COG5184     21 CWGDNSYGQLGDGTTTDRSTPV-RVPGL---SNVVAVAAGGDHTCALKADGTVWCWGNNSYGQLGdgTTTDRTTPVKVPG 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429   81 LADqhIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSvAVPRLIQkLNQQTILQVSCGNWHCLALAADGQFFT 160
Cdd:COG5184     97 LTG--VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNR-LTPVQVD-AGLSGVVAIAAGGYHTCALKSDGTVWC 172

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429  161 WGKNSHGQLGLGkEFPSQASPQRVRSLEGIplAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLR 240
Cdd:COG5184    173 WGANSYGQLGDG-TTTDRPTPVQVGGLSGV--VAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTDRATPVQVAGLT 249

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429  241 TqkVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELmgSEVTQIACGRQHTLAfVPSSGLIYAFG 320
Cdd:COG5184    250 G--VVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVPGL--SGVVAVAAGSSHTCA-LLTDGTVWCWG 324

                          330       340
                   ....*....|....*....|.
gi 1770726429  321 CGARGQLGTGHTCNVkcPSPV 341
Cdd:COG5184    325 DNAYGQLGDGTTTDR--STPV 343
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
313-377 2.75e-07

Regulator of chromosome condensation (RCC1) repeat;


:

Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 47.90  E-value: 2.75e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1770726429  313 SGLIYAFGCGARGQLGTGHTCNVKCPSPVKGywaahsgqlsaradrFKYHIVKQIFSGGDQTFVL 377
Cdd:pfam00415    1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEG---------------LSGNKVVQVACGGDHTVAL 50
 
Name Accession Description Interval E-value
HECTc cd00078
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ...
 694-1040 1.18e-139

HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.


Pssm-ID: 238033 [Multi-domain]  Cd Length: 352  Bit Score: 423.13  E-value: 1.18e-139
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429  694 LVLHVRRNNLVGDALRELSIHSDIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMFTYYQDS-NLLWFSDT 772
Cdd:cd00078      1 LKITVRRDRILEDALRQLSKVSSSDLKKVLEVEFVGEEGIDAGGVTREFFTLVSKELFNPSYGLFRYTPDDsGLLYPNPS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429  773 CFV---EHNWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSPTEGRSLQELLDYPGEdvEETFCLNF 849
Cdd:cd00078     81 SFAdedHLKLFRFLGRLLGKALYEGRLLDLPFSRAFYKKLLGKPLSLEDLEELDPELYKSLKELLDNDGD--EDDLELTF 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429  850 TICR-ESYGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVG 928
Cdd:cd00078    159 TIELdSSFGGAVTVELKPGGRDIPVTNENKEEYVDLYVDYRLNKGIEEQVEAFRDGFSEVIPEELLSLFTPEELELLICG 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429  929 NSNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASLQ--IVIQSTASGEEYLPV 1006
Cdd:cd00078    239 SEDIDLEDLKKNTEYKGGYSSDSPTIQWFWEVLESFTNEERKKFLQFVTGSSRLPVGGFADLNpkFTIRRVGSPDDRLPT 318

                          330       340       350
                   ....*....|....*....|....*....|....
gi 1770726429 1007 AHTCYNLLDLPKYSSKEILSARLTQALDNYEGFS 1040
Cdd:cd00078    319 AHTCFNLLKLPPYSSKEILREKLLYAINEGAGFG 352
HECTc smart00119
Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to ...
 718-1039 2.55e-128

Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to E2 enzymes.


Pssm-ID: 214523  Cd Length: 328  Bit Score: 392.75  E-value: 2.55e-128
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429   718 DLKKP-LKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMFTYYQDSNLLWFSDTCFVEH----NWFHLIGITCGLAIY 792
Cdd:smart00119    1 DLKKRvLEIEFEGEEGLDGGGVTREFFFLLSKELFNPDYGLFRYSPNDYLLYPNPRSGFANeehlSYFRFIGRVLGKALY 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429   793 NSTVVDLHFPLALYKKLLNVKPGLEDLKELSPTEGRSLQEL-LDYPGEDVEEtfcLNFTICRES-YGVIEQKKLIPGGDN 870
Cdd:smart00119   81 DNRLLDLFFARPFYKKLLGKPVTLHDLESLDPELYKSLKWLlLNNDTSEELD---LTFSIVLTSeFGQVKVVELKPGGSN 157

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429   871 VTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGNSNYNWEELEETAIYKGDYSAT 950
Cdd:smart00119  158 IPVTEENKKEYVHLVIEYRLNKGIEKQLEAFREGFSEVIPENLLKLFDPEELELLICGSPEIDVDDLKSNTEYKGGYSAN 237

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429   951 HPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASLQ--IVIQSTASGEEYLPVAHTCYNLLDLPKYSSKEILSAR 1028
Cdd:smart00119  238 SQTIKWFWEVVESFTNEERRKLLQFVTGSSRLPVGGFAALSpkFTIRKAGSDDERLPTAHTCFNRLKLPPYSSKEILREK 317

                           330
                    ....*....|.
gi 1770726429  1029 LTQALDNYEGF 1039
Cdd:smart00119  318 LLLAINEGKGF 328
HECT pfam00632
HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl ...
 752-1042 2.81e-98

HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.


Pssm-ID: 459880  Cd Length: 304  Bit Score: 312.62  E-value: 2.81e-98
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429  752 NPIYGMFTY-YQDSNLLWFSDTCFVEH-----NWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSPT 825
Cdd:pfam00632    9 DPNYGLFEYeTEDDRTYWFNPSSSESPdlellDYFKFLGKLLGKAIYNGILLDLPFPPFFYKKLLGEPLTLEDLESIDPE 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429  826 EGRSLQELLDYPgEDVEETFCLNFTIcrESYGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGF 905
Cdd:pfam00632   89 LYKSLKSLLNMD-NDDDEDLGLTFTI--PVFGESKTIELIPNGRNIPVTNENKEEYIRLYVDYRLNKSIEPQLEAFRKGF 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429  906 LKVCGGKVLELFQPSELRAMMVGNSNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIY 985
Cdd:pfam00632  166 YSVIPKEALSLFTPEELELLICGSPEIDVEDLKKNTEYDGGYTKNSPTIQWFWEILEEFSPEQRRLFLKFVTGSSRLPVG 245

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1770726429  986 GMASLQ-IVIQS-TASGEEYLPVAHTCYNLLDLPKYSSKEILSARLTQALDNYEGFSLA 1042
Cdd:pfam00632  246 GFKSLPkFTIVRkGGDDDDRLPTAHTCFNRLKLPDYSSKEILKEKLLIAIEEGEGFGLS 304
HUL4 COG5021
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
392-1042 3.46e-83

Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227354 [Multi-domain]  Cd Length: 872  Bit Score: 288.59  E-value: 3.46e-83
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429  392 TMNQAHYTSLINDETIAVWRQKLSEHNN------ANTINGVVQILSSAACWNGSFLEKKIDEHFKTSPKI---PGIDLNS 462
Cdd:COG5021    198 AVSNVEKSEPDNVLFGLPYRSALTMRTNflkldtGNLSGEVQALLARYISIKLVIKKLYLGPGPDASSRIstlIIRLSNT 277

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429  463 TRVlfEKLMN-SQHSMILEQILnsfescLIPQLSSSPPDVEAMRIYLILPEFpLLQDSKYyiTLTIPLAMAILRLDTNPS 541
Cdd:COG5021    278 NLN--RRLSYiLSHSSFEDSLL------RLNSLFSTRADSFGRTYYLDHDRI-LTQYSRP--LLEETLGESTSFLVVNND 346

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429  542 KVLDNWWSQVCPKYFMKLVNLYKGAVLYLLRGRKTFL----IPVLFNNYITAALKLLE-------KLYKVNLKVKHVEYD 610
Cdd:COG5021    347 DSSSIKDLPHQVGSNPFLEAHPEFSELLKNQSRGTTRdfrnKPTGWSSSIEDLGQFLFsdfltssSTYEDLRREQLGRES 426

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429  611 TFYIPEISNlVDIQEDYLMWFLHqAGMDTVTLCSYPFIFDAQAKTKMLQTDAELQMQVAVNGANLQNVFMLLTLEPLLAR 690
Cdd:COG5021    427 DESFYVASN-VQQQRASREGPLL-SGWKTRLNNLYRFYFVEHRKKTLTKNDSRLGSFISLNKLDIRRIKEDKRRKLFYSL 504

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429  691 S-------PFLVLHVRRNNLVGDALRELSIHSDIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMFTYYQD 763
Cdd:COG5021    505 KqkakifdPYLHIKVRRDRVFEDSYREIMDESGDDLKKTLEIEFVGEEGIDAGGLTREWLFLLSKEMFNPDYGLFEYITE 584

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429  764 SNL-LWFSDTCFV--EH-NWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSPTEGRSLQELLDYPGE 839
Cdd:COG5021    585 DLYtLPINPLSSInpEHlSYFKFLGRVIGKAIYDSRILDVQFSKAFYKKLLGKPVSLVDLESLDPELYRSLVWLLNNDID 664

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429  840 dvEETFCLNFTICRESYGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQP 919
Cdd:COG5021    665 --ETILDLTFTVEDDSFGESRTVELIPNGRNISVTNENKKEYVKKVVDYKLNKRVEKQFSAFKSGFSEIIPPDLLQIFDE 742

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429  920 SELRAMMVG-NSNYNWEELEETAIYKGdYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASLQ------- 991
Cdd:COG5021    743 SELELLIGGiPEDIDIDDWKSNTAYHG-YTEDSPIIVWFWEIISEFDFEERAKLLQFVTGTSRIPINGFKDLQgsdgvrk 821

                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1770726429  992 --IVIQSTASgeEYLPVAHTCYNLLDLPKYSSKEILSARLTQALDNYEGFSLA 1042
Cdd:COG5021    822 ftIEKGGTDD--DRLPSAHTCFNRLKLPEYSSKEKLRSKLLTAINEGAGFGLL 872
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 3-341 1.92e-79

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 262.99  E-value: 1.92e-79
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429    3 CWGYWSLGQPGISTNLQGIVAEpQVCGFisdRSVKEVACGGNHSVFLLEDGEVYTCGLNTKGQLG--HEREGNKPEQIGA 80
Cdd:COG5184     21 CWGDNSYGQLGDGTTTDRSTPV-RVPGL---SNVVAVAAGGDHTCALKADGTVWCWGNNSYGQLGdgTTTDRTTPVKVPG 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429   81 LADqhIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSvAVPRLIQkLNQQTILQVSCGNWHCLALAADGQFFT 160
Cdd:COG5184     97 LTG--VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNR-LTPVQVD-AGLSGVVAIAAGGYHTCALKSDGTVWC 172

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429  161 WGKNSHGQLGLGkEFPSQASPQRVRSLEGIplAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLR 240
Cdd:COG5184    173 WGANSYGQLGDG-TTTDRPTPVQVGGLSGV--VAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTDRATPVQVAGLT 249

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429  241 TqkVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELmgSEVTQIACGRQHTLAfVPSSGLIYAFG 320
Cdd:COG5184    250 G--VVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVPGL--SGVVAVAAGSSHTCA-LLTDGTVWCWG 324

                          330       340
                   ....*....|....*....|.
gi 1770726429  321 CGARGQLGTGHTCNVkcPSPV 341
Cdd:COG5184    325 DNAYGQLGDGTTTDR--STPV 343
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
208-257 6.56e-15

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 69.47  E-value: 6.56e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1770726429  208 SGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVL 257
Cdd:pfam00415    1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
313-377 2.75e-07

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 47.90  E-value: 2.75e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1770726429  313 SGLIYAFGCGARGQLGTGHTCNVKCPSPVKGywaahsgqlsaradrFKYHIVKQIFSGGDQTFVL 377
Cdd:pfam00415    1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEG---------------LSGNKVVQVACGGDHTVAL 50
 
Name Accession Description Interval E-value
HECTc cd00078
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ...
 694-1040 1.18e-139

HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.


Pssm-ID: 238033 [Multi-domain]  Cd Length: 352  Bit Score: 423.13  E-value: 1.18e-139
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429  694 LVLHVRRNNLVGDALRELSIHSDIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMFTYYQDS-NLLWFSDT 772
Cdd:cd00078      1 LKITVRRDRILEDALRQLSKVSSSDLKKVLEVEFVGEEGIDAGGVTREFFTLVSKELFNPSYGLFRYTPDDsGLLYPNPS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429  773 CFV---EHNWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSPTEGRSLQELLDYPGEdvEETFCLNF 849
Cdd:cd00078     81 SFAdedHLKLFRFLGRLLGKALYEGRLLDLPFSRAFYKKLLGKPLSLEDLEELDPELYKSLKELLDNDGD--EDDLELTF 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429  850 TICR-ESYGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVG 928
Cdd:cd00078    159 TIELdSSFGGAVTVELKPGGRDIPVTNENKEEYVDLYVDYRLNKGIEEQVEAFRDGFSEVIPEELLSLFTPEELELLICG 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429  929 NSNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASLQ--IVIQSTASGEEYLPV 1006
Cdd:cd00078    239 SEDIDLEDLKKNTEYKGGYSSDSPTIQWFWEVLESFTNEERKKFLQFVTGSSRLPVGGFADLNpkFTIRRVGSPDDRLPT 318

                          330       340       350
                   ....*....|....*....|....*....|....
gi 1770726429 1007 AHTCYNLLDLPKYSSKEILSARLTQALDNYEGFS 1040
Cdd:cd00078    319 AHTCFNLLKLPPYSSKEILREKLLYAINEGAGFG 352
HECTc smart00119
Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to ...
 718-1039 2.55e-128

Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to E2 enzymes.


Pssm-ID: 214523  Cd Length: 328  Bit Score: 392.75  E-value: 2.55e-128
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429   718 DLKKP-LKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMFTYYQDSNLLWFSDTCFVEH----NWFHLIGITCGLAIY 792
Cdd:smart00119    1 DLKKRvLEIEFEGEEGLDGGGVTREFFFLLSKELFNPDYGLFRYSPNDYLLYPNPRSGFANeehlSYFRFIGRVLGKALY 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429   793 NSTVVDLHFPLALYKKLLNVKPGLEDLKELSPTEGRSLQEL-LDYPGEDVEEtfcLNFTICRES-YGVIEQKKLIPGGDN 870
Cdd:smart00119   81 DNRLLDLFFARPFYKKLLGKPVTLHDLESLDPELYKSLKWLlLNNDTSEELD---LTFSIVLTSeFGQVKVVELKPGGSN 157

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429   871 VTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGNSNYNWEELEETAIYKGDYSAT 950
Cdd:smart00119  158 IPVTEENKKEYVHLVIEYRLNKGIEKQLEAFREGFSEVIPENLLKLFDPEELELLICGSPEIDVDDLKSNTEYKGGYSAN 237

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429   951 HPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASLQ--IVIQSTASGEEYLPVAHTCYNLLDLPKYSSKEILSAR 1028
Cdd:smart00119  238 SQTIKWFWEVVESFTNEERRKLLQFVTGSSRLPVGGFAALSpkFTIRKAGSDDERLPTAHTCFNRLKLPPYSSKEILREK 317

                           330
                    ....*....|.
gi 1770726429  1029 LTQALDNYEGF 1039
Cdd:smart00119  318 LLLAINEGKGF 328
HECT pfam00632
HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl ...
 752-1042 2.81e-98

HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.


Pssm-ID: 459880  Cd Length: 304  Bit Score: 312.62  E-value: 2.81e-98
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429  752 NPIYGMFTY-YQDSNLLWFSDTCFVEH-----NWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSPT 825
Cdd:pfam00632    9 DPNYGLFEYeTEDDRTYWFNPSSSESPdlellDYFKFLGKLLGKAIYNGILLDLPFPPFFYKKLLGEPLTLEDLESIDPE 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429  826 EGRSLQELLDYPgEDVEETFCLNFTIcrESYGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGF 905
Cdd:pfam00632   89 LYKSLKSLLNMD-NDDDEDLGLTFTI--PVFGESKTIELIPNGRNIPVTNENKEEYIRLYVDYRLNKSIEPQLEAFRKGF 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429  906 LKVCGGKVLELFQPSELRAMMVGNSNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIY 985
Cdd:pfam00632  166 YSVIPKEALSLFTPEELELLICGSPEIDVEDLKKNTEYDGGYTKNSPTIQWFWEILEEFSPEQRRLFLKFVTGSSRLPVG 245

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1770726429  986 GMASLQ-IVIQS-TASGEEYLPVAHTCYNLLDLPKYSSKEILSARLTQALDNYEGFSLA 1042
Cdd:pfam00632  246 GFKSLPkFTIVRkGGDDDDRLPTAHTCFNRLKLPDYSSKEILKEKLLIAIEEGEGFGLS 304
HUL4 COG5021
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
392-1042 3.46e-83

Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227354 [Multi-domain]  Cd Length: 872  Bit Score: 288.59  E-value: 3.46e-83
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429  392 TMNQAHYTSLINDETIAVWRQKLSEHNN------ANTINGVVQILSSAACWNGSFLEKKIDEHFKTSPKI---PGIDLNS 462
Cdd:COG5021    198 AVSNVEKSEPDNVLFGLPYRSALTMRTNflkldtGNLSGEVQALLARYISIKLVIKKLYLGPGPDASSRIstlIIRLSNT 277

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429  463 TRVlfEKLMN-SQHSMILEQILnsfescLIPQLSSSPPDVEAMRIYLILPEFpLLQDSKYyiTLTIPLAMAILRLDTNPS 541
Cdd:COG5021    278 NLN--RRLSYiLSHSSFEDSLL------RLNSLFSTRADSFGRTYYLDHDRI-LTQYSRP--LLEETLGESTSFLVVNND 346

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429  542 KVLDNWWSQVCPKYFMKLVNLYKGAVLYLLRGRKTFL----IPVLFNNYITAALKLLE-------KLYKVNLKVKHVEYD 610
Cdd:COG5021    347 DSSSIKDLPHQVGSNPFLEAHPEFSELLKNQSRGTTRdfrnKPTGWSSSIEDLGQFLFsdfltssSTYEDLRREQLGRES 426

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429  611 TFYIPEISNlVDIQEDYLMWFLHqAGMDTVTLCSYPFIFDAQAKTKMLQTDAELQMQVAVNGANLQNVFMLLTLEPLLAR 690
Cdd:COG5021    427 DESFYVASN-VQQQRASREGPLL-SGWKTRLNNLYRFYFVEHRKKTLTKNDSRLGSFISLNKLDIRRIKEDKRRKLFYSL 504

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429  691 S-------PFLVLHVRRNNLVGDALRELSIHSDIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMFTYYQD 763
Cdd:COG5021    505 KqkakifdPYLHIKVRRDRVFEDSYREIMDESGDDLKKTLEIEFVGEEGIDAGGLTREWLFLLSKEMFNPDYGLFEYITE 584

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429  764 SNL-LWFSDTCFV--EH-NWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSPTEGRSLQELLDYPGE 839
Cdd:COG5021    585 DLYtLPINPLSSInpEHlSYFKFLGRVIGKAIYDSRILDVQFSKAFYKKLLGKPVSLVDLESLDPELYRSLVWLLNNDID 664

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429  840 dvEETFCLNFTICRESYGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQP 919
Cdd:COG5021    665 --ETILDLTFTVEDDSFGESRTVELIPNGRNISVTNENKKEYVKKVVDYKLNKRVEKQFSAFKSGFSEIIPPDLLQIFDE 742

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429  920 SELRAMMVG-NSNYNWEELEETAIYKGdYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASLQ------- 991
Cdd:COG5021    743 SELELLIGGiPEDIDIDDWKSNTAYHG-YTEDSPIIVWFWEIISEFDFEERAKLLQFVTGTSRIPINGFKDLQgsdgvrk 821

                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1770726429  992 --IVIQSTASgeEYLPVAHTCYNLLDLPKYSSKEILSARLTQALDNYEGFSLA 1042
Cdd:COG5021    822 ftIEKGGTDD--DRLPSAHTCFNRLKLPEYSSKEKLRSKLLTAINEGAGFGLL 872
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 3-341 1.92e-79

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 262.99  E-value: 1.92e-79
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429    3 CWGYWSLGQPGISTNLQGIVAEpQVCGFisdRSVKEVACGGNHSVFLLEDGEVYTCGLNTKGQLG--HEREGNKPEQIGA 80
Cdd:COG5184     21 CWGDNSYGQLGDGTTTDRSTPV-RVPGL---SNVVAVAAGGDHTCALKADGTVWCWGNNSYGQLGdgTTTDRTTPVKVPG 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429   81 LADqhIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSvAVPRLIQkLNQQTILQVSCGNWHCLALAADGQFFT 160
Cdd:COG5184     97 LTG--VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNR-LTPVQVD-AGLSGVVAIAAGGYHTCALKSDGTVWC 172

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429  161 WGKNSHGQLGLGkEFPSQASPQRVRSLEGIplAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLR 240
Cdd:COG5184    173 WGANSYGQLGDG-TTTDRPTPVQVGGLSGV--VAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTDRATPVQVAGLT 249

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429  241 TqkVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELmgSEVTQIACGRQHTLAfVPSSGLIYAFG 320
Cdd:COG5184    250 G--VVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVPGL--SGVVAVAAGSSHTCA-LLTDGTVWCWG 324

                          330       340
                   ....*....|....*....|.
gi 1770726429  321 CGARGQLGTGHTCNVkcPSPV 341
Cdd:COG5184    325 DNAYGQLGDGTTTDR--STPV 343
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 38-343 1.76e-72

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 244.12  E-value: 1.76e-72
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429   38 EVACGGNHSVFLLEDGEVYTCGLNTKGQLGHEREGN--KPEQIGALADqhIIHVACGESHSLALSDRGQLFSWGAGSDGQ 115
Cdd:COG5184      2 QVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDrsTPVRVPGLSN--VVAVAAGGDHTCALKADGTVWCWGNNSYGQ 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429  116 LGLMTTEDSvAVPRLIQKLNqqTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGkEFPSQASPQRVR-SLEGIplAQ 194
Cdd:COG5184     80 LGDGTTTDR-TTPVKVPGLT--GVVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDG-TTTNRLTPVQVDaGLSGV--VA 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429  195 VAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTqkVVYISCGEEHTAVLTKSGGVFTFGAGSCGQL 274
Cdd:COG5184    154 IAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGGLSG--VVAVAAGGDHSCALKSDGTVWCWGSNSSGQL 231

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1770726429  275 GHDSMNDEVNPRRVLELMGseVTQIACGRQHTLAfVPSSGLIYAFGCGARGQLGTGHTCNVKCPSPVKG 343
Cdd:COG5184    232 GDGTTTDRATPVQVAGLTG--VVAIAAGGSHTCA-LKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVPG 297
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 87-343 1.60e-63

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 219.08  E-value: 1.60e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429   87 IHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSvAVPRLIQKLnqQTILQVSCGNWHCLALAADGQFFTWGKNSH 166
Cdd:COG5184      1 TQVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDR-STPVRVPGL--SNVVAVAAGGDHTCALKADGTVWCWGNNSY 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429  167 GQLGLGkEFPSQASPQRVRSLEGIplAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVkLLRTQKVVY 246
Cdd:COG5184     78 GQLGDG-TTTDRTTPVKVPGLTGV--VAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQV-DAGLSGVVA 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429  247 ISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELmgSEVTQIACGRQHTLAfVPSSGLIYAFGCGARGQ 326
Cdd:COG5184    154 IAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGGL--SGVVAVAAGGDHSCA-LKSDGTVWCWGSNSSGQ 230

                          250
                   ....*....|....*..
gi 1770726429  327 LGTGHTCNVKCPSPVKG 343
Cdd:COG5184    231 LGDGTTTDRATPVQVAG 247
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 1-233 6.99e-37

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 142.42  E-value: 6.99e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429    1 MLCWGYWSLGQPGISTNlqgivaepqvcgfiSDRSVkevacggnhsvflledgevytcglntkgqlgheregnkPEQIGA 80
Cdd:COG5184    170 VWCWGANSYGQLGDGTT--------------TDRPT--------------------------------------PVQVGG 197

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429   81 LADqhIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSvAVPRLIQKLNqqTILQVSCGNWHCLALAADGQFFT 160
Cdd:COG5184    198 LSG--VVAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTDR-ATPVQVAGLT--GVVAIAAGGSHTCALKSDGTVWC 272

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1770726429  161 WGKNSHGQLGLGKEfPSQASPQRVRSLEGIplAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESP 233
Cdd:COG5184    273 WGDNSYGQLGDGTT-TDRSTPVKVPGLSGV--VAVAAGSSHTCALLTDGTVWCWGDNAYGQLGDGTTTDRSTP 342
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 193-377 1.89e-32

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 129.33  E-value: 1.89e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429  193 AQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTqkVVYISCGEEHTAVLTKSGGVFTFGAGSCG 272
Cdd:COG5184      1 TQVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVRVPGLSN--VVAVAAGGDHTCALKADGTVWCWGNNSYG 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770726429  273 QLGHDSMNDEVNPRRVLELmgSEVTQIACGRQHTLAfVPSSGLIYAFGCGARGQLGTGHTCNVKCPSPVkgywaahSGQL 352
Cdd:COG5184     79 QLGDGTTTDRTTPVKVPGL--TGVVAVAAGYYHSCA-LKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQV-------DAGL 148

                          170       180
                   ....*....|....*....|....*
gi 1770726429  353 SAradrfkyhiVKQIFSGGDQTFVL 377
Cdd:COG5184    149 SG---------VVAIAAGGYHTCAL 164
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
208-257 6.56e-15

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 69.47  E-value: 6.56e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1770726429  208 SGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVL 257
Cdd:pfam00415    1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
103-152 2.67e-14

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 67.93  E-value: 2.67e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1770726429  103 GQLFSWGAGSDGQLGLMTTEdSVAVPRLIQKLNQQTILQVSCGNWHCLAL 152
Cdd:pfam00415    2 GRVYTWGRNDYGQLGLGTTE-NVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
155-205 1.61e-13

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 65.62  E-value: 1.61e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1770726429  155 DGQFFTWGKNSHGQLGLGKEFpSQASPQRVRSLEGIPLAQVAAGGAHSFAL 205
Cdd:pfam00415    1 DGRVYTWGRNDYGQLGLGTTE-NVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
52-99 2.34e-13

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 65.23  E-value: 2.34e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1770726429   52 DGEVYTCGLNTKGQLGHEREGNK--PEQIGALADQHIIHVACGESHSLAL 99
Cdd:pfam00415    1 DGRVYTWGRNDYGQLGLGTTENVlvPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
260-308 1.57e-12

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 62.92  E-value: 1.57e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1770726429  260 SGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLA 308
Cdd:pfam00415    1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVA 49
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
36-65 2.51e-09

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 53.20  E-value: 2.51e-09
                           10        20        30
                   ....*....|....*....|....*....|
gi 1770726429   36 VKEVACGGNHSVFLLEDGEVYTCGLNTKGQ 65
Cdd:pfam13540    1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
139-168 1.26e-07

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 48.57  E-value: 1.26e-07
                           10        20        30
                   ....*....|....*....|....*....|
gi 1770726429  139 ILQVSCGNWHCLALAADGQFFTWGKNSHGQ 168
Cdd:pfam13540    1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
313-377 2.75e-07

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 47.90  E-value: 2.75e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1770726429  313 SGLIYAFGCGARGQLGTGHTCNVKCPSPVKGywaahsgqlsaradrFKYHIVKQIFSGGDQTFVL 377
Cdd:pfam00415    1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEG---------------LSGNKVVQVACGGDHTVAL 50
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
86-115 3.76e-07

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 47.03  E-value: 3.76e-07
                           10        20        30
                   ....*....|....*....|....*....|
gi 1770726429   86 IIHVACGESHSLALSDRGQLFSWGAGSDGQ 115
Cdd:pfam13540    1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
193-221 3.47e-06

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 44.34  E-value: 3.47e-06
                           10        20
                   ....*....|....*....|....*....
gi 1770726429  193 AQVAAGGAHSFALSLSGAVFGWGMNNAGQ 221
Cdd:pfam13540    2 VSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
244-273 8.31e-06

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 43.18  E-value: 8.31e-06
                           10        20        30
                   ....*....|....*....|....*....|
gi 1770726429  244 VVYISCGEEHTAVLTKSGGVFTFGAGSCGQ 273
Cdd:pfam13540    1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
296-326 1.10e-03

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 37.40  E-value: 1.10e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1770726429  296 VTQIACGRQHTLAFVpSSGLIYAFGCGARGQ 326
Cdd:pfam13540    1 VVSVAAGDNHTLALT-SDGRVYCWGDNSYGQ 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH