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Conserved domains on  [gi|1770500663|ref|NP_001362397|]
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nicotinamide riboside kinase 2 isoform 4 [Homo sapiens]

Protein Classification

nicotinamide riboside kinase( domain architecture ID 10113996)

nicotinamide riboside kinase catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NRK1 cd02024
Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide ...
 4-137 1.72e-75

Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR salvage pathway of NAD+ biosynthesis in addition to the pathways through nicotinic acid mononucleotide (NaMN). This enzyme can also phosphorylate the anticancer drug tiazofurin, which is an analog of nicotinamide riboside.


:

Pssm-ID: 238982 [Multi-domain]  Cd Length: 187  Bit Score: 222.97  E-value: 1.72e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770500663   4 IVGIGGMTNGGKTTLTNSLLRALPNCCVIHQDDFFKaplfqPQDQIAVGEDGFKQWDVLESLDMEAMLDTVQAWLSSP-- 81
Cdd:cd02024     1 IVGISGVTNSGKTTLAKLLQRILPNCCVIHQDDFFK-----PEDEIPVDENGFKQWDVLEALDMEAMMSTLDYWRETGhf 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1770500663  82 QKFARAHGVSVQPE------------------ASDTHILLLEGFLLYSYKPLVDLYSRRYFLTVPYEECKWRRS 137
Cdd:cd02024    76 PKFLRSHGNENDPEkefiedaqieetkadllgAEDLHILIVDGFLLYNYKPLVDLFDIRYFLRVPYETCKRRRE 149
 
Name Accession Description Interval E-value
NRK1 cd02024
Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide ...
 4-137 1.72e-75

Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR salvage pathway of NAD+ biosynthesis in addition to the pathways through nicotinic acid mononucleotide (NaMN). This enzyme can also phosphorylate the anticancer drug tiazofurin, which is an analog of nicotinamide riboside.


Pssm-ID: 238982 [Multi-domain]  Cd Length: 187  Bit Score: 222.97  E-value: 1.72e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770500663   4 IVGIGGMTNGGKTTLTNSLLRALPNCCVIHQDDFFKaplfqPQDQIAVGEDGFKQWDVLESLDMEAMLDTVQAWLSSP-- 81
Cdd:cd02024     1 IVGISGVTNSGKTTLAKLLQRILPNCCVIHQDDFFK-----PEDEIPVDENGFKQWDVLEALDMEAMMSTLDYWRETGhf 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1770500663  82 QKFARAHGVSVQPE------------------ASDTHILLLEGFLLYSYKPLVDLYSRRYFLTVPYEECKWRRS 137
Cdd:cd02024    76 PKFLRSHGNENDPEkefiedaqieetkadllgAEDLHILIVDGFLLYNYKPLVDLFDIRYFLRVPYETCKRRRE 149
Udk COG0572
Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway ...
 3-136 2.79e-14

Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 440337 [Multi-domain]  Cd Length: 206  Bit Score: 66.79  E-value: 2.79e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770500663   3 LIVGIGGMTNGGKTTLTNSLLRALP--NCCVIHQDDFFKaplfqPQDQIAVGEDGFKQWDVLESLDMEAMLDTVQAWLS- 79
Cdd:COG0572     8 RIIGIAGPSGSGKTTFARRLAEQLGadKVVVISLDDYYK-----DREHLPLDERGKPNFDHPEAFDLDLLNEHLEPLKAg 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1770500663  80 -SPQK----FARaHGVSVQPE-ASDTHILLLEGFLLYSYKPLVDLYSRRYFLTVPYEECKWRR 136
Cdd:COG0572    83 eSVELpvydFAT-GTRSGETVkVEPADVIIVEGIHALNDELLRDLLDLKIYVDADTDVRLIRR 144
PRK08233 PRK08233
hypothetical protein; Provisional
 4-60 5.13e-06

hypothetical protein; Provisional


Pssm-ID: 181310 [Multi-domain]  Cd Length: 182  Bit Score: 43.96  E-value: 5.13e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1770500663   4 IVGIGGMTNGGKTTLTNSLLRALPNCCVIHqDDFFKAPLfQPQDQIAVGEDG--FKQWD 60
Cdd:PRK08233    5 IITIAAVSGGGKTTLTERLTHKLKNSKALY-FDRYDFDN-CPEDICKWIDKGanYSEWV 61
 
Name Accession Description Interval E-value
NRK1 cd02024
Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide ...
 4-137 1.72e-75

Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR salvage pathway of NAD+ biosynthesis in addition to the pathways through nicotinic acid mononucleotide (NaMN). This enzyme can also phosphorylate the anticancer drug tiazofurin, which is an analog of nicotinamide riboside.


Pssm-ID: 238982 [Multi-domain]  Cd Length: 187  Bit Score: 222.97  E-value: 1.72e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770500663   4 IVGIGGMTNGGKTTLTNSLLRALPNCCVIHQDDFFKaplfqPQDQIAVGEDGFKQWDVLESLDMEAMLDTVQAWLSSP-- 81
Cdd:cd02024     1 IVGISGVTNSGKTTLAKLLQRILPNCCVIHQDDFFK-----PEDEIPVDENGFKQWDVLEALDMEAMMSTLDYWRETGhf 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1770500663  82 QKFARAHGVSVQPE------------------ASDTHILLLEGFLLYSYKPLVDLYSRRYFLTVPYEECKWRRS 137
Cdd:cd02024    76 PKFLRSHGNENDPEkefiedaqieetkadllgAEDLHILIVDGFLLYNYKPLVDLFDIRYFLRVPYETCKRRRE 149
Udk COG0572
Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway ...
 3-136 2.79e-14

Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 440337 [Multi-domain]  Cd Length: 206  Bit Score: 66.79  E-value: 2.79e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770500663   3 LIVGIGGMTNGGKTTLTNSLLRALP--NCCVIHQDDFFKaplfqPQDQIAVGEDGFKQWDVLESLDMEAMLDTVQAWLS- 79
Cdd:COG0572     8 RIIGIAGPSGSGKTTFARRLAEQLGadKVVVISLDDYYK-----DREHLPLDERGKPNFDHPEAFDLDLLNEHLEPLKAg 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1770500663  80 -SPQK----FARaHGVSVQPE-ASDTHILLLEGFLLYSYKPLVDLYSRRYFLTVPYEECKWRR 136
Cdd:COG0572    83 eSVELpvydFAT-GTRSGETVkVEPADVIIVEGIHALNDELLRDLLDLKIYVDADTDVRLIRR 144
PRK08233 PRK08233
hypothetical protein; Provisional
 4-60 5.13e-06

hypothetical protein; Provisional


Pssm-ID: 181310 [Multi-domain]  Cd Length: 182  Bit Score: 43.96  E-value: 5.13e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1770500663   4 IVGIGGMTNGGKTTLTNSLLRALPNCCVIHqDDFFKAPLfQPQDQIAVGEDG--FKQWD 60
Cdd:PRK08233    5 IITIAAVSGGGKTTLTERLTHKLKNSKALY-FDRYDFDN-CPEDICKWIDKGanYSEWV 61
UMPK_like cd02028
Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the ...
 4-106 9.15e-05

Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK).


Pssm-ID: 238986 [Multi-domain]  Cd Length: 179  Bit Score: 40.37  E-value: 9.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770500663   4 IVGIGGMTNGGKTTLTNSLLRAL----PNCCVIHQDDFFKaPLFQPQDqiavgEDGFkqWDVLESLDMEAMLDTVQAWLS 79
Cdd:cd02028     1 VVGIAGPSGSGKTTFAKKLSNQLrvngIGPVVISLDDYYV-PRKTPRD-----EDGN--YDFESILDLDLLNKNLHDLLN 72

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1770500663  80 S-----PQKFARAHG-----VSVQPeasDTHILLLEG 106
Cdd:cd02028    73 GkevelPIYDFRTGKrrgyrKLKLP---PSGVVILEG 106
PRK05480 PRK05480
uridine/cytidine kinase; Provisional
 4-39 5.26e-03

uridine/cytidine kinase; Provisional


Pssm-ID: 235492 [Multi-domain]  Cd Length: 209  Bit Score: 35.52  E-value: 5.26e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1770500663   4 IVGIGGMTNGGKTTLTNSLLRALPN--CCVIHQDDFFK 39
Cdd:PRK05480    8 IIGIAGGSGSGKTTVASTIYEELGDesIAVIPQDSYYK 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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