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Conserved domains on  [gi|1734337641|ref|NP_001360616|]
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MFS domain-containing protein [Caenorhabditis elegans]

Protein Classification

OFA family MFS transporter( domain architecture ID 13024068)

OFA (oxalate:formate antiporter) family major facilitator superfamily (MFS) transporter similar to OFA, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation, to generate an electrochemical proton gradient that is the source of energy for ATP synthesis in this cell

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 23-496 7.35e-92

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 285.27  E-value: 7.35e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641  23 RICVILFGAVSIHLTIGTYHTFGNMLPYMASYMrnftDPSVRIEHMMWIPTFQGCFPFAMVIGGLTSStFSPRVSAFIGC 102
Cdd:cd17353     1 RRWLVLLGAVLMHLILGYQYAWSVFNPPLSSAL----GWSLASVALAFTLTIVFLAISAPFAGRLVDR-GGPRKAILIGG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641 103 FLVTSSVALSAYAIQhsFALFFIVYGLLFGLGSGIAYVTAVSTAINWAPDKIGVISGIVAAGFGLSSSIFAPIQTMIVNP 182
Cdd:cd17353    76 ILFGLGFILSAFAIS--LPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINT 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641 183 LNLPATkdgyflqpellhrvpalFTKLAVIYGIMQAMALIVVCDPPFRIRHSGLGSLSEyifssssasanqrysgvsysr 262
Cdd:cd17353   154 VGVPTT-----------------FLILGIIFLIIIVIGAFLIRDPPKGWVPPGVDPLAN--------------------- 195

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641 263 vrldevatsstdepksrstesileeddedmdedyerpvfdNDEDTTIQMTSSEMLKSPTFYCLFASLFCCSFYANMFYNL 342
Cdd:cd17353   196 ----------------------------------------NAENSPRDYTPREMLRTPTFWLLWLMFFLNATAGLMLIGQ 235

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641 343 YKTYGESFI-EDDMFMAMAFSIASVANAIARIGWGYLTDRTSFQIALSTATCLASVFLLTMPMTRELgKMAFLFWLVGTF 421
Cdd:cd17353   236 AKPIGQEFAgLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSV-AVLFVLGVALIG 314

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1734337641 422 ICMGATHALFITATVKCFGNRHKANNYGYLILSTTTSGILLAAISQFYLKAIGYTYLFIITSIFPFCAFIFISCI 496
Cdd:cd17353   315 FCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALALALLL 389
 
Name Accession Description Interval E-value
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 23-496 7.35e-92

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 285.27  E-value: 7.35e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641  23 RICVILFGAVSIHLTIGTYHTFGNMLPYMASYMrnftDPSVRIEHMMWIPTFQGCFPFAMVIGGLTSStFSPRVSAFIGC 102
Cdd:cd17353     1 RRWLVLLGAVLMHLILGYQYAWSVFNPPLSSAL----GWSLASVALAFTLTIVFLAISAPFAGRLVDR-GGPRKAILIGG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641 103 FLVTSSVALSAYAIQhsFALFFIVYGLLFGLGSGIAYVTAVSTAINWAPDKIGVISGIVAAGFGLSSSIFAPIQTMIVNP 182
Cdd:cd17353    76 ILFGLGFILSAFAIS--LPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINT 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641 183 LNLPATkdgyflqpellhrvpalFTKLAVIYGIMQAMALIVVCDPPFRIRHSGLGSLSEyifssssasanqrysgvsysr 262
Cdd:cd17353   154 VGVPTT-----------------FLILGIIFLIIIVIGAFLIRDPPKGWVPPGVDPLAN--------------------- 195

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641 263 vrldevatsstdepksrstesileeddedmdedyerpvfdNDEDTTIQMTSSEMLKSPTFYCLFASLFCCSFYANMFYNL 342
Cdd:cd17353   196 ----------------------------------------NAENSPRDYTPREMLRTPTFWLLWLMFFLNATAGLMLIGQ 235

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641 343 YKTYGESFI-EDDMFMAMAFSIASVANAIARIGWGYLTDRTSFQIALSTATCLASVFLLTMPMTRELgKMAFLFWLVGTF 421
Cdd:cd17353   236 AKPIGQEFAgLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSV-AVLFVLGVALIG 314

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1734337641 422 ICMGATHALFITATVKCFGNRHKANNYGYLILSTTTSGILLAAISQFYLKAIGYTYLFIITSIFPFCAFIFISCI 496
Cdd:cd17353   315 FCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALALALLL 389
2A0111 TIGR00890
oxalate/formate antiporter family transporter; This subfamily belongs to the major facilitator ...
 27-491 3.69e-43

oxalate/formate antiporter family transporter; This subfamily belongs to the major facilitator family. Members include the oxalate/formate antiporter of Oxalobacter formigenes, where one substrate is decarboxylated in the cytosol into the other to consume a proton and drive an ion gradient. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273323 [Multi-domain]  Cd Length: 377  Bit Score: 157.22  E-value: 3.69e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641  27 ILFGAVSIHLTIGTYHTFGNMLPYMASYMRnftdpSVRIEHMMWIPTFQGCFPFAMVIGGLTSSTFSPRVSAFIGCFLVT 106
Cdd:TIGR00890   5 VLVGTVIMCFTSGYVYTWTLLAPPLGRYFG-----VGVTAVAIWFTLLLIGLAMSMPVGGLLADKFGPRAVAMLGGILYG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641 107 SSVALsaYAIQHSFALFFIVYGLLfGLGSGIAYVTAVSTAINWAPDKIGVISGIVAAGFGLSSSIFAPIQTMIVNplnlp 186
Cdd:TIGR00890  80 LGFTF--YAIADSLAALYLTYGLA-SAGVGIAYGIALNTAVKWFPDKRGLASGIIIGGYGLGSFILSPLITSVIN----- 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641 187 atkdgyflqpelLHRVPALFTKLAVIYGIMQAMALIVVCDPPfrirhsglgslseyifssssasanqrysgvsysrvrld 266
Cdd:TIGR00890 152 ------------LEGVPAAFIYMGIIFLLVIVLGAFLIGYPP-------------------------------------- 181

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641 267 evatsstdepksrstesileeddedmdedyERPVFDNDEDTTIQMTSSEMLKSPTFYCLFASLFCCSFYANMFYNLYKTY 346
Cdd:TIGR00890 182 ------------------------------GQLIKTNIEVSVKDYTVWEMLRTPQFWVLYLSFFLNAVSGLLLIGLYKPY 231

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641 347 GESFIEDDMFMAMAFSIASVANAIARIGWGYLTDRTSFQIALSTATCLASVFLLTMPMTRELGKMAFLFWLVGTFICMGA 426
Cdd:TIGR00890 232 GQSLGLSDGFLVLAVSISSIFNGGGRPFLGALSDKIGRQKTMSIVFGISAVGMAAMLFIPMLNDVLFLATVALVFFTWGG 311

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1734337641 427 THALFITATVKCFGNRHKANNYGYLILSTTTSGILLAAISQFYLKAIGYTYLFIITSIFPFCAFI 491
Cdd:TIGR00890 312 TISLFPSLVSDIFGPANSAANYGFLYTAKAVAGIFGGLIASHALTEIGFEYTFIVTGAFALTSLA 376
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
26-492 1.30e-14

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 75.30  E-value: 1.30e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641  26 VILFGAVSIHLTIGTYHTFGNMLPYMASYMrNFTDPSVriehmMWIPTFQG-CFPFAMVIGGLTSSTFSPRVSAFIGCFL 104
Cdd:COG2223     6 VLLLATLAFFLAFGVWYLWSVLAPPLAEEF-GLSAAQL-----GLLFAIPVlVGALLRIPLGFLVDRFGPRRVLLIGLLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641 105 VTSSVALSAYAiqHSFALFfIVYGLLFGLGSGIAYVTAVSTAINW-APDKIGVISGIVAAGFGLSSSIFAPIQTMIVNPL 183
Cdd:COG2223    80 LGIGLLLLALA--VSYWLL-LLLGLLLGIGGGGSFAVGIALVSKWfPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641 184 NLPATkdgyflqpellhrvpalFTKLAVIYGIMQAMALIVVCDPPFRIRHSGLGSLSEYIfssssasanqrysgvsysrv 263
Cdd:COG2223   157 GWRNA-----------------FLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQL-------------------- 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641 264 rldevatsstdepksrstesileeddedmdedyerpvfdndedttiqmtssEMLKSPTFYCLFASLFCCSFYANMFYNLY 343
Cdd:COG2223   200 ---------------------------------------------------EALRDPRFWLLSLLYFGTFGSFIGFSSWL 228

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641 344 KTYGESFIEDDMFMAMAF-SIASVANAIARIGWGYLTDRTSFQIALSTATCLASVFLLTMPMTReLGKMAFLFWLVGTFI 422
Cdd:COG2223   229 PPYLVDQFGLSAATAGLLaALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALAL-GSLWLFLVLFLLLGL 307

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1734337641 423 CMGATHALFITATVKCFGNRHKANNYGYLILSTTTSGILLAAISQFYLKAIG-YTYLFIITSIFPFCAFIF 492
Cdd:COG2223   308 ALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVL 378
MFS_1 pfam07690
Major Facilitator Superfamily;
325-493 7.79e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 41.63  E-value: 7.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641 325 LFASLFCCSFYANMFYNLYKTYGESFIEDDMFMAMAFSIASVANAIARIGWGYLTDRTSFQIALSTATCLASVFLLTMPM 404
Cdd:pfam07690   2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641 405 TRELGKMAFLFWLVGtfICMGATHALFITATVKCFGNRHKANNYGYLILSTTTSGILLAAISQFYLKAIGYTYLFIITSI 484
Cdd:pfam07690  82 ASSLWLLLVLRVLQG--LGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159


                  ....*....
gi 1734337641 485 FPFCAFIFI 493
Cdd:pfam07690 160 LSLLAAVLL 168
 
Name Accession Description Interval E-value
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 23-496 7.35e-92

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 285.27  E-value: 7.35e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641  23 RICVILFGAVSIHLTIGTYHTFGNMLPYMASYMrnftDPSVRIEHMMWIPTFQGCFPFAMVIGGLTSStFSPRVSAFIGC 102
Cdd:cd17353     1 RRWLVLLGAVLMHLILGYQYAWSVFNPPLSSAL----GWSLASVALAFTLTIVFLAISAPFAGRLVDR-GGPRKAILIGG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641 103 FLVTSSVALSAYAIQhsFALFFIVYGLLFGLGSGIAYVTAVSTAINWAPDKIGVISGIVAAGFGLSSSIFAPIQTMIVNP 182
Cdd:cd17353    76 ILFGLGFILSAFAIS--LPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINT 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641 183 LNLPATkdgyflqpellhrvpalFTKLAVIYGIMQAMALIVVCDPPFRIRHSGLGSLSEyifssssasanqrysgvsysr 262
Cdd:cd17353   154 VGVPTT-----------------FLILGIIFLIIIVIGAFLIRDPPKGWVPPGVDPLAN--------------------- 195

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641 263 vrldevatsstdepksrstesileeddedmdedyerpvfdNDEDTTIQMTSSEMLKSPTFYCLFASLFCCSFYANMFYNL 342
Cdd:cd17353   196 ----------------------------------------NAENSPRDYTPREMLRTPTFWLLWLMFFLNATAGLMLIGQ 235

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641 343 YKTYGESFI-EDDMFMAMAFSIASVANAIARIGWGYLTDRTSFQIALSTATCLASVFLLTMPMTRELgKMAFLFWLVGTF 421
Cdd:cd17353   236 AKPIGQEFAgLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSV-AVLFVLGVALIG 314

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1734337641 422 ICMGATHALFITATVKCFGNRHKANNYGYLILSTTTSGILLAAISQFYLKAIGYTYLFIITSIFPFCAFIFISCI 496
Cdd:cd17353   315 FCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALALALLL 389
2A0111 TIGR00890
oxalate/formate antiporter family transporter; This subfamily belongs to the major facilitator ...
 27-491 3.69e-43

oxalate/formate antiporter family transporter; This subfamily belongs to the major facilitator family. Members include the oxalate/formate antiporter of Oxalobacter formigenes, where one substrate is decarboxylated in the cytosol into the other to consume a proton and drive an ion gradient. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273323 [Multi-domain]  Cd Length: 377  Bit Score: 157.22  E-value: 3.69e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641  27 ILFGAVSIHLTIGTYHTFGNMLPYMASYMRnftdpSVRIEHMMWIPTFQGCFPFAMVIGGLTSSTFSPRVSAFIGCFLVT 106
Cdd:TIGR00890   5 VLVGTVIMCFTSGYVYTWTLLAPPLGRYFG-----VGVTAVAIWFTLLLIGLAMSMPVGGLLADKFGPRAVAMLGGILYG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641 107 SSVALsaYAIQHSFALFFIVYGLLfGLGSGIAYVTAVSTAINWAPDKIGVISGIVAAGFGLSSSIFAPIQTMIVNplnlp 186
Cdd:TIGR00890  80 LGFTF--YAIADSLAALYLTYGLA-SAGVGIAYGIALNTAVKWFPDKRGLASGIIIGGYGLGSFILSPLITSVIN----- 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641 187 atkdgyflqpelLHRVPALFTKLAVIYGIMQAMALIVVCDPPfrirhsglgslseyifssssasanqrysgvsysrvrld 266
Cdd:TIGR00890 152 ------------LEGVPAAFIYMGIIFLLVIVLGAFLIGYPP-------------------------------------- 181

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641 267 evatsstdepksrstesileeddedmdedyERPVFDNDEDTTIQMTSSEMLKSPTFYCLFASLFCCSFYANMFYNLYKTY 346
Cdd:TIGR00890 182 ------------------------------GQLIKTNIEVSVKDYTVWEMLRTPQFWVLYLSFFLNAVSGLLLIGLYKPY 231

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641 347 GESFIEDDMFMAMAFSIASVANAIARIGWGYLTDRTSFQIALSTATCLASVFLLTMPMTRELGKMAFLFWLVGTFICMGA 426
Cdd:TIGR00890 232 GQSLGLSDGFLVLAVSISSIFNGGGRPFLGALSDKIGRQKTMSIVFGISAVGMAAMLFIPMLNDVLFLATVALVFFTWGG 311

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1734337641 427 THALFITATVKCFGNRHKANNYGYLILSTTTSGILLAAISQFYLKAIGYTYLFIITSIFPFCAFI 491
Cdd:TIGR00890 312 TISLFPSLVSDIFGPANSAANYGFLYTAKAVAGIFGGLIASHALTEIGFEYTFIVTGAFALTSLA 376
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
26-492 1.30e-14

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 75.30  E-value: 1.30e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641  26 VILFGAVSIHLTIGTYHTFGNMLPYMASYMrNFTDPSVriehmMWIPTFQG-CFPFAMVIGGLTSSTFSPRVSAFIGCFL 104
Cdd:COG2223     6 VLLLATLAFFLAFGVWYLWSVLAPPLAEEF-GLSAAQL-----GLLFAIPVlVGALLRIPLGFLVDRFGPRRVLLIGLLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641 105 VTSSVALSAYAiqHSFALFfIVYGLLFGLGSGIAYVTAVSTAINW-APDKIGVISGIVAAGFGLSSSIFAPIQTMIVNPL 183
Cdd:COG2223    80 LGIGLLLLALA--VSYWLL-LLLGLLLGIGGGGSFAVGIALVSKWfPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641 184 NLPATkdgyflqpellhrvpalFTKLAVIYGIMQAMALIVVCDPPFRIRHSGLGSLSEYIfssssasanqrysgvsysrv 263
Cdd:COG2223   157 GWRNA-----------------FLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQL-------------------- 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641 264 rldevatsstdepksrstesileeddedmdedyerpvfdndedttiqmtssEMLKSPTFYCLFASLFCCSFYANMFYNLY 343
Cdd:COG2223   200 ---------------------------------------------------EALRDPRFWLLSLLYFGTFGSFIGFSSWL 228

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641 344 KTYGESFIEDDMFMAMAF-SIASVANAIARIGWGYLTDRTSFQIALSTATCLASVFLLTMPMTReLGKMAFLFWLVGTFI 422
Cdd:COG2223   229 PPYLVDQFGLSAATAGLLaALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALAL-GSLWLFLVLFLLLGL 307

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1734337641 423 CMGATHALFITATVKCFGNRHKANNYGYLILSTTTSGILLAAISQFYLKAIG-YTYLFIITSIFPFCAFIF 492
Cdd:COG2223   308 ALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVL 378
MFS_MCT_like cd17314
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ...
 83-490 1.20e-09

Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340872 [Multi-domain]  Cd Length: 385  Bit Score: 60.12  E-value: 1.20e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641  83 VIGGLTSSTFSPRVSAFIGCFLVTSSVALSAYAIQHSFAlfFIVYGLLFGLGSGIAYVTAVSTAINWAPDKIGVISGIVA 162
Cdd:cd17314    56 PILGFIADSFGPRPLMALAGIMVLAGYTYLSYVFNSFPL--SYACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPT 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641 163 AGFGLSSSIFAPIQTMIVnplnlpatkdgyflqpellhrvpaLFTKLAVIYGIMQAMALIVvcdppfrIRHSGLGSLSEY 242
Cdd:cd17314   134 TGYSLGLVLGSPLLRILW------------------------VFYGLALVYTILGILAAIV-------LSVVSLLGFKEP 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641 243 IFSSSSASANQRYSGvsysrvrldevatsstdepksrstesileeddedmdedyerpvfdndedttiqmTSSEMLKSPTF 322
Cdd:cd17314   183 PDNQARLHVQKKKTQ------------------------------------------------------TMGEIFRDKVF 208

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641 323 YCLFASLFCCSFYANMFYNLYKTYGESFIEDDMFMAMAF-SIASVANAIARIGWGYLTDRTSFQIALSTAT-CLASVFLL 400
Cdd:cd17314   209 WILFIAIFLVLIGGFLFIANMASLVRSLQLDAPSFVTKLmSIYGLFNAFGRLLWGIVADFFGGRLSTLSILlTILGLGLC 288

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641 401 TMPMTRELGKMAFLFWLVGTFICMGATHALFITATVKCFGNRHKANNYGYLILSTTTSGILLAAI-SQFYLKAIGYTYLF 479
Cdd:cd17314   289 AFLFLLKMTPVGLVLTGSLLGFSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLgAKFYDRTPSYISAV 368

                         410
                  ....*....|.
gi 1734337641 480 IITSIFPFCAF 490
Cdd:cd17314   369 YIYAVIVFLAS 379
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 68-494 4.61e-08

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 54.87  E-value: 4.61e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641  68 MMWIP-TFQGCFPFAMVIGGLTSSTFSPRVSAFIGCFLVTSSVALSAYAiqHSFALFFIVYGLLFGLGSGIAYVTAVSTA 146
Cdd:cd17352    40 IAWIGsLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFA--TSLWQLYLTYGVLGGLGLGLIYSPAIVIV 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641 147 INWAPDKIGVISGIVAAGFGLSSSIFAPiqtmivnplnlpatkdgyflqpellhrvpaLFTKLAVIYGIMQAMALivvcd 226
Cdd:cd17352   118 GQYFEKKRGLATGIAVAGSGVGTFVFPP------------------------------LLRYLLDNYGWRGALLI----- 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641 227 ppfrirhsgLGSLSEYIFSSSSASAnqrysgvsysrvrldevatsstdepksrstesileeddedmdedyerpvfdnded 306
Cdd:cd17352   163 ---------LGGLCLNLCVCGLLLR------------------------------------------------------- 178

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641 307 ttiqmtsseMLKSPTFYCLFASLFCCSFYANMFYNLYKTYGESFIEDDMFMAMAFSIASVANAIARIGWGYLTDRTSFQI 386
Cdd:cd17352   179 ---------LLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGR 249

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641 387 ALSTATCL--ASVFLLTMPMTRELGKMAFLFWLVGtfICMGATHALFITATVKCFGNRHKANNYGYLILSTTTSGILLAA 464
Cdd:cd17352   250 LYLYIFTLliLGLSLLAFPLATTYVGLIVFSVLFG--FCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPP 327

                         410       420       430
                  ....*....|....*....|....*....|.
gi 1734337641 465 ISQFYLKAIG-YTYLFIITSIFPFCAFIFIS 494
Cdd:cd17352   328 IAGLLRDYTGdYDAAFYFCGACLLLSGVLLF 358
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 71-456 2.79e-06

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 49.58  E-value: 2.79e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641  71 IPTFQGCFPFAMVIGGLTS-------STFSPRVSAFIGCFLVTSSVALSAYAiqHSFALFFIVYGLLFGLGSGIAYVTAV 143
Cdd:cd17355    37 RAVISLAFTVGLLAFGLAQpfvgrllDRFGPRRVMLLGLLLLAAGLVLLALA--TSLWQLYLLWGLLGGGGAGTLAAVAF 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641 144 STAINWAPD-KIGVISGIVAAGFGLSSSIFAPIQTMIVNPLNLPATkdgyflqpellhrvpalftklAVIYGIMqaMALI 222
Cdd:cd17355   115 ATVAAWWFErRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTA---------------------LLVLALL--ALLV 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641 223 VVCDPPFRIRHSGlgslseyifssssasanqrysgvsysrvrldEVATSSTDEPKSRSTESILEeddedmdedyerpvfd 302
Cdd:cd17355   172 LVPVLLLLRRRPA-------------------------------DLALRAYDDASPASPGSTLK---------------- 204

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641 303 ndedttiqmtssEMLKSPTFYCLFASLFCCSFYANMFYNLYKTYGESFIEDDMFMAMAFSIASVANAIARIGWGYLTDRT 382
Cdd:cd17355   205 ------------EALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRY 272

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1734337641 383 SFQIALSTATCLASVFLLTMPMTRELGKMAFLFWLVGTFiCMGATHALFITATVKCFGNRHKANNYGYLILSTT 456
Cdd:cd17355   273 SPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGL-GWGATVPLTAALAARYFGARSYGTLFGLVFAPHQ 345
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
321-493 6.49e-06

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 48.33  E-value: 6.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641 321 TFYCLFASLFCCSFYANMFYN-----LYKTYGESFIEddmfMAMAFSIASVANAIARIGWGYLTDRT--SFQIALSTATC 393
Cdd:COG2271   181 RFWLLALAYFLVYFALYGFLTwlptyLVEVRGLSLAQ----AGLLLSLPFLAGIVGSLLGGWLSDRLgrRRKLVLAIGLL 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641 394 LASVFLLTMPMTRELgkMAFLFWLVGTFICMGATHALFITATVKCFGNRHKANNYGYLILSTTTSGILLAAISQFYLKAI 473
Cdd:COG2271   257 LAALALLLLALLPSP--ALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDAT 334

                         170       180
                  ....*....|....*....|
gi 1734337641 474 GYTYLFIITSIFPFCAFIFI 493
Cdd:COG2271   335 GYQAAFLLLAALALLAALLA 354
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 76-171 1.70e-04

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 43.70  E-value: 1.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641  76 GCFPFAMVIGGLtSSTFSPRVSAFIGCFLVTSSVALSAYAIQHSFALFFIVYGLLFGLGSGIAYVTAVSTAINWAP-DKI 154
Cdd:cd17321   216 AMLVAAPLAGRL-ADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPkEKA 294

                          90
                  ....*....|....*..
gi 1734337641 155 GVISGIVAAGFGLSSSI 171
Cdd:cd17321   295 GAASGILNTARQLGGAL 311
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
77-175 2.38e-04

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 43.32  E-value: 2.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641  77 CFPFAMVIGGLTSSTFSPRVSAFIGCFLVTSSVALSAYAiqHSFALFFIVYgLLFGLGSGIAYVTAVSTAINWAPDKIGV 156
Cdd:COG2807    65 AFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLA--PSVALLLAGT-ALIGAGIAVGNVLLPGLIKRWFPDRVGL 141

                          90
                  ....*....|....*....
gi 1734337641 157 ISGIVAAGFGLSSSIFAPI 175
Cdd:COG2807   142 MTGLYTAAMGLGAALAAGL 160
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
74-180 4.13e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 42.55  E-value: 4.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641  74 FQGCFPFAMVIGGLTSSTFSPRVSAFIGcfLVTSSVALSAYAIQHSFALFFIVYgLLFGLGSGIAYVTAVSTAINWAPDK 153
Cdd:COG2271    54 FFLGYALGQIPAGLLADRFGRRRVLAIG--LLLWGLATLLFGFATSFWQLLLLR-FLLGLGEAGFFPAALKLIAEWFPPK 130

                          90       100
                  ....*....|....*....|....*...
gi 1734337641 154 I-GVISGIVAAGFGLSSSIFAPIQTMIV 180
Cdd:COG2271   131 ErGRALGIFNAGGPLGGALAPPLLGWLL 158
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
311-493 4.75e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 42.27  E-value: 4.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641 311 MTSSEMLKSPTFYCLFASLFCCSFYANMFYNLYKTYGESFIEDDMFMAMAFSIASVANAIARIGWGYLTDRTSFQIALST 390
Cdd:COG2814     1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641 391 ATCLASVFLLTMPMTRELGkmAFLFWLVGTFICMGATHALFITATVKCFGNRHKANNYGYLILSTTTSGILLAAISQFYL 470
Cdd:COG2814    81 GLLLFALGSLLCALAPSLW--LLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLA 158

                         170       180
                  ....*....|....*....|...
gi 1734337641 471 KAIGYTYLFIITSIFPFCAFIFI 493
Cdd:COG2814   159 DLFGWRWVFLVNAVLALLALLLL 181
MFS_Mch1p_like cd17354
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major ...
 308-453 5.36e-04

Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major Facilitator Superfamily of transporters; Yeast monocarboxylate transporter-homologous (Mch) proteins are putative transporters that do not transport monocarboxylic acids across the plasma membrane, and may play roles distinct from their mammalian counterparts. Their function has not been determined. The Mch1p-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340912 [Multi-domain]  Cd Length: 385  Bit Score: 42.24  E-value: 5.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641 308 TIQMTSSEMLKSPTFYCLFASLFCCSFYANMFYNLYKTYGESFIEDDMFmAMAFSIASVANAIARIGWGYLTD------- 380
Cdd:cd17354   184 IVSIEEGEFLKDIDFWLLFISLFLGVGPGEMFINNLGQIGQSLTGPSNT-STLVSLFSIFSFLGRLLSGLLSDlfvrkfr 262

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1734337641 381 --RTSFQIALSTATCLASVFLLTMPMtreLGKMAFLFWLVGtfICMGATHALFITATVKCFGNRHKANNYGYLIL 453
Cdd:cd17354   263 lpRPSRMVLLLLILSLGHLLQAFGLP---SGALYVASALIG--FGYGGLFSIAPTIVSELFGLKNFGTNYGFLML 332
MFS_1 pfam07690
Major Facilitator Superfamily;
325-493 7.79e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 41.63  E-value: 7.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641 325 LFASLFCCSFYANMFYNLYKTYGESFIEDDMFMAMAFSIASVANAIARIGWGYLTDRTSFQIALSTATCLASVFLLTMPM 404
Cdd:pfam07690   2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641 405 TRELGKMAFLFWLVGtfICMGATHALFITATVKCFGNRHKANNYGYLILSTTTSGILLAAISQFYLKAIGYTYLFIITSI 484
Cdd:pfam07690  82 ASSLWLLLVLRVLQG--LGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159


                  ....*....
gi 1734337641 485 FPFCAFIFI 493
Cdd:pfam07690 160 LSLLAAVLL 168
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
357-492 1.75e-03

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 40.62  E-value: 1.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641 357 MAMAFSIASVANAIARIGWGYLTDRTSFQIALSTATCLASVFLLTMPMTRELGKMAFLFWLVGtfICMGATHALFITATV 436
Cdd:COG2271    47 LGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLG--LGEAGFFPAALKLIA 124

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1734337641 437 KCFGNRHKANNYGYLILSTTTSGILLAAISQFYLKAIGYTYLFIITSIFPFCAFIF 492
Cdd:COG2271   125 EWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALL 180
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 80-171 2.81e-03

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 39.95  E-value: 2.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641  80 FAMVIGGLTSSTFSPRVSAFIGCFLVTssVALSAYAIQHSFALFFIVYGLLFGLGSGiAYV--TAVSTAINWAPDKIGVI 157
Cdd:cd17355   260 VGRLLSGWLGDRYSPRRLLAASYALRA--LGLALLLLLPFPPLALLLFAALFGLGWG-ATVplTAALAARYFGARSYGTL 336

                          90
                  ....*....|....
gi 1734337641 158 SGIVAAGFGLSSSI 171
Cdd:cd17355   337 FGLVFAPHQLGSAL 350
MFS_MCT9 cd17428
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ...
 90-180 4.49e-03

Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340986 [Multi-domain]  Cd Length: 361  Bit Score: 39.41  E-value: 4.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641  90 STFSPRVSAFIGCFLVTSSVALSAYAIQHSFALFfiVYGLLFGLGSGIAYVTAVSTAINWAPDKIGVISGIVAAGFGLSS 169
Cdd:cd17428    63 SSFGARPVTIFSGFMVAGGLMLSAFAPNIYFLIF--SYGIVVGLGCGLVYAATVTITCQYFDKRRGLALGLISTGSSVGL 140

                          90
                  ....*....|.
gi 1734337641 170 SIFAPIQTMIV 180
Cdd:cd17428   141 FIYAALQRELI 151
MFS_BCD_PucC-like cd06176
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator ...
 80-169 5.46e-03

Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator Superfamily; The bacteriochlorophyll delivery (BCD) family, also called PucC family, is composed of the PucC protein and related proteins including LhaA (also called ORF477 and F1696) and bacteriochlorophyll synthase 44.5 kDa chain (also called ORF428). These proteins are found in photosynthetic organisms. Rhodobacter capsulatus LhaA and PucC are implicated in light-harvesting complex 1 and 2 (LH1 and LH2) assembly. PucC may function to shepherd or sequester LH2 alpha and beta proteins to facilitate proper assembly, as well as deliver bacteriochlorophyll a to nascent LH2 complexes. The BCD family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 349950 [Multi-domain]  Cd Length: 409  Bit Score: 39.02  E-value: 5.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641  80 FAMVIGG-LTSSTFSPRVSAFIGCFLVTSS-VALSAYAIQHSFALFFIVYgLLFGLGSGIAYVTAVSTAINWAPDK---- 153
Cdd:cd06176   274 LGMLLAGfLLSRRLGKKRTAALGCLLSALGfLLLALAGLLGNPWLFRPGV-FLLGLGNGLFTVGALTLMMDLTGEGtagl 352

                          90
                  ....*....|....*..
gi 1734337641 154 -IGVISGIVAAGFGLSS 169
Cdd:cd06176   353 fMGLWGAAQALARGLGT 369
MFS_MCT12 cd17424
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ...
 84-180 5.58e-03

Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340982 [Multi-domain]  Cd Length: 363  Bit Score: 39.02  E-value: 5.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641  84 IGGLTSSTFSPRVSAFIGCFLVTSSVALSAYAiqHSFALFFIVYGLLFGLGSGIAYVTAVSTAINWAPDKIGVISGIVAA 163
Cdd:cd17424    57 LGSLISNHLSCQVGIILGGLLASTGLILSSFA--TSLEYLYLTLGVLTGLGFALCYSPAIAMVGKYFHKRKALAYGIAMS 134

                          90
                  ....*....|....*..
gi 1734337641 164 GFGLSSSIFAPIQTMIV 180
Cdd:cd17424   135 GSGIGTFILAPVVQLLI 151
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 325-493 6.88e-03

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 38.71  E-value: 6.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641 325 LFASLFCCSFYANMFYNLYKTYGESFIEDDMFMAMAFSIASVANAIARIGWGYLTDRTSFQIALSTATCLASVFLLTMPM 404
Cdd:cd17325     1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641 405 TRelgkmaFLFWLVGTFICMGATHALFITAT----VKCFGNRHKANNYGYLILSTTTSGILLAAISQFYLKAIGYTYLFI 480
Cdd:cd17325    81 AT------SYWQLLLARFLQGLASAAVWPAAmaliADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFL 154

                         170
                  ....*....|...
gi 1734337641 481 ITSIFPFCAFIFI 493
Cdd:cd17325   155 VCAALALLALVLA 167
MFS_MCT8_10 cd17420
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ...
 80-188 7.59e-03

Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340978 [Multi-domain]  Cd Length: 400  Bit Score: 38.66  E-value: 7.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641  80 FAMVIGGLTSSTFSPRVSAFIGCflVTSSVALSAYAIQHSFALFFIVYGLLFGLGSGIAYVTAVSTAINWAPDKIGVISG 159
Cdd:cd17420    58 FCSPIVSCFTDKIGCRLTAFAGA--AVSFGGLLLSSFCSSIGALYFTYGIMFGCGCSFAYQPSLVILGHYFKRRLGLVNG 135

                          90       100
                  ....*....|....*....|....*....
gi 1734337641 160 IVAAGFGLSSSIFAPIQTMIVNPLNLPAT 188
Cdd:cd17420   136 FVTAGSSVFTVILPPLLRKLLDSYGLEGT 164
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
314-445 8.61e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 38.42  E-value: 8.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641 314 SEMLKSPTFYCLFASLFCCSFYANMFYNLYKTYGESFIE-DDMFMAMAFSIASVANAIARIGWGYLTDRTSFQIALSTAT 392
Cdd:COG2814   201 RELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGlSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGL 280

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1734337641 393 CLASVFLLTMPMTRELGKMAFLFWLVGtfICMGATHALFITATVKCFGNRHKA 445
Cdd:COG2814   281 LLLALGLLLLALAGSLWLLLLALFLLG--FGFGLLFPLLQALVAELAPPEARG 331
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 320-492 9.75e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 38.18  E-value: 9.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641 320 PTFYCLFASLFCCSFYANMFYNLYKTYGESFIEDDMFMAMAFSIASVANAIARIGWGYLTDRTSFQIALSTATCLASVFL 399
Cdd:cd06174   204 GLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALG 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734337641 400 LTMPMTRELGKMAFLFWLVgTFICMGATHALFITATVKCFGNRHKANNYGYLILSTTTSGILLAAISQFYLKA-IGYTYL 478
Cdd:cd06174   284 LALLLLAPSLLLLLLLLLL-LGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAAtFGLTGA 362

                         170
                  ....*....|....
gi 1734337641 479 FIITSIFPFCAFIF 492
Cdd:cd06174   363 FLVLAVLLLLAAIL 376
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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