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Conserved domains on  [gi|1734336523|ref|NP_001360556|]
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RING-type domain-containing protein [Caenorhabditis elegans]

Protein Classification

RING finger protein( domain architecture ID 11613669)

RING finger protein may function as an E3 ubiquitin protein ligase that mediates the ubiquitination of target proteins by bringing the ubiquitin-charged E2 ubiquitin-conjugating enzyme and the acceptor protein together to enable the direct transfer of ubiquitin

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
vRING-HC_IRF2BP1-like cd16511
variant of RING finger, HC subclass, found in interferon regulatory factor 2-binding protein ...
 111-166 1.42e-33

variant of RING finger, HC subclass, found in interferon regulatory factor 2-binding protein IRF-2BP1, IRF-2BP2, and similar proteins; This subfamily includes IRF-2BP1, IRF-2BP2, and their homolog, IRF-2BP-like, also known as IRF-2BPL or C14orf4. IRF-2BP1 and IRF-2BP2 are nuclear proteins that bind to the C-terminal repression domain of IRF-2 and act as IRF-2-dependent transcriptional corepressors, both enhancer-activated and basal transcription. IRF-2BPL is expressed in the mediobasal hypothalamus and plays a critical function in regulating the female reproductive neuroendocrine axis. All subfamily members contain a C-terminal variant C3HC4-type RING-HC finger.


:

Pssm-ID: 438174  Cd Length: 56  Bit Score: 116.37  E-value: 1.42e-33
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1734336523 111 LRCTLCNERLEDTHFVQCPTVSIHKFCFPCSRSSIKDQCKSSDMYCPSGDKCPLVG 166
Cdd:cd16511     1 LCCTLCHERLEDTHFVQCPSVPSHKFCFPCSRDSIKRQGAGGEVYCPSGEKCPLVG 56
 
Name Accession Description Interval E-value
vRING-HC_IRF2BP1-like cd16511
variant of RING finger, HC subclass, found in interferon regulatory factor 2-binding protein ...
 111-166 1.42e-33

variant of RING finger, HC subclass, found in interferon regulatory factor 2-binding protein IRF-2BP1, IRF-2BP2, and similar proteins; This subfamily includes IRF-2BP1, IRF-2BP2, and their homolog, IRF-2BP-like, also known as IRF-2BPL or C14orf4. IRF-2BP1 and IRF-2BP2 are nuclear proteins that bind to the C-terminal repression domain of IRF-2 and act as IRF-2-dependent transcriptional corepressors, both enhancer-activated and basal transcription. IRF-2BPL is expressed in the mediobasal hypothalamus and plays a critical function in regulating the female reproductive neuroendocrine axis. All subfamily members contain a C-terminal variant C3HC4-type RING-HC finger.


Pssm-ID: 438174  Cd Length: 56  Bit Score: 116.37  E-value: 1.42e-33
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1734336523 111 LRCTLCNERLEDTHFVQCPTVSIHKFCFPCSRSSIKDQCKSSDMYCPSGDKCPLVG 166
Cdd:cd16511     1 LCCTLCHERLEDTHFVQCPSVPSHKFCFPCSRDSIKRQGAGGEVYCPSGEKCPLVG 56
 
Name Accession Description Interval E-value
vRING-HC_IRF2BP1-like cd16511
variant of RING finger, HC subclass, found in interferon regulatory factor 2-binding protein ...
 111-166 1.42e-33

variant of RING finger, HC subclass, found in interferon regulatory factor 2-binding protein IRF-2BP1, IRF-2BP2, and similar proteins; This subfamily includes IRF-2BP1, IRF-2BP2, and their homolog, IRF-2BP-like, also known as IRF-2BPL or C14orf4. IRF-2BP1 and IRF-2BP2 are nuclear proteins that bind to the C-terminal repression domain of IRF-2 and act as IRF-2-dependent transcriptional corepressors, both enhancer-activated and basal transcription. IRF-2BPL is expressed in the mediobasal hypothalamus and plays a critical function in regulating the female reproductive neuroendocrine axis. All subfamily members contain a C-terminal variant C3HC4-type RING-HC finger.


Pssm-ID: 438174  Cd Length: 56  Bit Score: 116.37  E-value: 1.42e-33
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1734336523 111 LRCTLCNERLEDTHFVQCPTVSIHKFCFPCSRSSIKDQCKSSDMYCPSGDKCPLVG 166
Cdd:cd16511     1 LCCTLCHERLEDTHFVQCPSVPSHKFCFPCSRDSIKRQGAGGEVYCPSGEKCPLVG 56
vRING-HC_IRF2BP2 cd16716
variant of RING finger, HC subclass, found in interferon regulatory factor 2 (IRF2)-binding ...
 111-176 1.81e-32

variant of RING finger, HC subclass, found in interferon regulatory factor 2 (IRF2)-binding protein 2 (IRF-2BP2); IRF-2BP2, also known as IRF-2-binding protein 2 or DIF-1, is a nuclear protein that binds to the C-terminal repression domain of IRF-2 and acts as an IRF-2-dependent transcriptional corepressor, both enhancer-activated and basal transcription. IRF-2BP2 also specifically interacts with the C-terminal domain of the nuclear factor of activated T cells NFAT1 transcription factor, and negatively regulates the NFAT1-dependent transactivation of NFAT-responsive promoters. Moreover, IRF2BP2 suppresses the transactivation activity of p53 on both Bax and p21 promoters. It also shows anti-apoptotic activity through the modulation of the death domain in NRIF3. In addition, IRF2BP2 functions as a cofactor of VGLL4 and plays a critical role controlling gene expression in skeletal, cardiac, and smooth muscle cells. It is a muscle-enriched transcription factor required to activate vascular endothelial growth factor-A (VEGF-A) expression. IRF-2BP2 contains an N-terminal C4-type zinc finger and a C-terminal variant C3HC4-type RING-HC finger. The zinc finger is responsible for the homo- and hetero-dimerization between different members of the IRF-2BP2 family. The RING-HC finger interacts with IRF2 and also with nuclear receptor interacting factor 3 (NRIF3).


Pssm-ID: 438376  Cd Length: 67  Bit Score: 114.03  E-value: 1.81e-32
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1734336523 111 LRCTLCNERLEDTHFVQCPTVSIHKFCFPCSRSSIKDQCKSSDMYCPSGDKCPLVGSAMPWAFMQG 176
Cdd:cd16716     2 LCCTLCHERLEDTHFVQCPSVPSHKFCFPCSRESIKQQGATGEVYCPSGEKCPLVGSNVPWAFMQG 67
vRING-HC_IRF2BP1 cd16715
variant of RING finger, HC subclass, found in interferon regulatory factor 2-binding protein 1 ...
 111-171 6.33e-30

variant of RING finger, HC subclass, found in interferon regulatory factor 2-binding protein 1 (IRF-2BP1); IRF-2BP1, also known as IRF-2-binding protein 1, is a nuclear protein that binds to the C-terminal repression domain of IRF-2 and acts as an IRF-2-dependent transcriptional corepressor, both enhancer-activated and basal transcription. It binds to Jun-dimerization protein 2 (JDP2), a member of the activating protein-1 (AP-1) family of transcription factors, and enhances the polyubiquitination of JDP2. It also represses activating transcription factor-2 (ATF2)-mediated transcriptional activation from a cyclic AMP-responsive element (CRE)-containing promoter. IRF-2BP1 contains an N-terminal C4-type zinc finger and a C-terminal variant C3HC4-type RING-HC finger.


Pssm-ID: 438375  Cd Length: 62  Bit Score: 107.00  E-value: 6.33e-30
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1734336523 111 LRCTLCNERLEDTHFVQCPTVSIHKFCFPCSRSSIKDQCKSSDMYCPSGDKCPLVGSAMPW 171
Cdd:cd16715     2 LCCTICHERLEDTHFVQCPSVPGHKFCFPCSRDFIKAQGPAGEVYCPSGDKCPLVGSNVPW 62
vRING-HC_IRF2BPL cd16717
variant of RING finger, HC subclass, found in interferon regulatory factor 2-binding ...
 111-171 3.94e-29

variant of RING finger, HC subclass, found in interferon regulatory factor 2-binding protein-like (IRF-2BPL); IRF-2BPL, also known as C14orf4 or enhanced at puberty protein 1(EAP1), is a homolog of interferon regulatory factor 2-binding proteins, IRF-2BP1 and IRF-2BP2. It is expressed in the mediobasal hypothalamus and plays a critical function in regulating the female reproductive neuroendocrine axis. IRF-2BPL is a proline-rich protein with polyglutamine and polyalanine tracks at the N-terminus and a C3HC4-type RING-HC finger domain with a partially new pattern at the C-terminus.


Pssm-ID: 438377  Cd Length: 66  Bit Score: 105.18  E-value: 3.94e-29
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1734336523 111 LRCTLCNERLEDTHFVQCPTVSIHKFCFPCSRSSIKDQCKSSDMYCPSGDKCPLVGSAMPW 171
Cdd:cd16717     6 LCCTICHERLEDTHFVQCPSVPSHKFCFPCSRESIKAQGATGEVYCPSGEKCPLVGSNVPW 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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