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Conserved domains on  [gi|1734329663|ref|NP_001360494|]
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WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
253-606 1.93e-25

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 109.23  E-value: 1.93e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734329663 253 DPYEKAIASDDLLHLAQVYQDETWTAKRL-------VTGMAFSehyPD---LLAVSYGpcdipneppGVIVVWNTKSKRM 322
Cdd:COG2319    87 SPDGRLLASASADGTVRLWDLATGLLLRTltghtgaVRSVAFS---PDgktLASGSAD---------GTVRLWDLATGKL 154
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734329663 323 TAEFIVYcQSEIQSVAFARfHAHLLLAGCESGQICVWDnrLTSRKLPinrspLTTQAHTYTVSCLAVvgTKNAHNFVSLS 402
Cdd:COG2319   155 LRTLTGH-SGAVTSVAFSP-DGKLLASGSDDGTVRLWD--LATGKLL-----RTLTGHTGAVRSVAF--SPDGKLLASGS 223
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734329663 403 RDGRICSWNVDNltqpvdGKELMTKEGKAASATRMSF-PIGemQTFVVGTDTGEIlaasR--NGADPAVIKTdvcYKGHS 479
Cdd:COG2319   224 ADGTVRLWDLAT------GKLLRTLTGHSGSVRSVAFsPDG--RLLASGSADGTV----RlwDLATGELLRT---LTGHS 288
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734329663 480 GTLTGIEFHRasgvvDfSHLFISSSHDWTVKLWSTKDANLKFSFESHPDLVLDVAWSPVHPAVfASIDADGNIFVWNLNE 559
Cdd:COG2319   289 GGVNSVAFSP-----D-GKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTL-ASGSDDGTVRLWDLAT 361
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 1734329663 560 dvEGPVARLRagaeGESVYMNRLIWSPDGKHVFVGDDEGRVHMYDVR 606
Cdd:COG2319   362 --GELLRTLT----GHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
253-606 1.93e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 109.23  E-value: 1.93e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734329663 253 DPYEKAIASDDLLHLAQVYQDETWTAKRL-------VTGMAFSehyPD---LLAVSYGpcdipneppGVIVVWNTKSKRM 322
Cdd:COG2319    87 SPDGRLLASASADGTVRLWDLATGLLLRTltghtgaVRSVAFS---PDgktLASGSAD---------GTVRLWDLATGKL 154
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734329663 323 TAEFIVYcQSEIQSVAFARfHAHLLLAGCESGQICVWDnrLTSRKLPinrspLTTQAHTYTVSCLAVvgTKNAHNFVSLS 402
Cdd:COG2319   155 LRTLTGH-SGAVTSVAFSP-DGKLLASGSDDGTVRLWD--LATGKLL-----RTLTGHTGAVRSVAF--SPDGKLLASGS 223
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734329663 403 RDGRICSWNVDNltqpvdGKELMTKEGKAASATRMSF-PIGemQTFVVGTDTGEIlaasR--NGADPAVIKTdvcYKGHS 479
Cdd:COG2319   224 ADGTVRLWDLAT------GKLLRTLTGHSGSVRSVAFsPDG--RLLASGSADGTV----RlwDLATGELLRT---LTGHS 288
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734329663 480 GTLTGIEFHRasgvvDfSHLFISSSHDWTVKLWSTKDANLKFSFESHPDLVLDVAWSPVHPAVfASIDADGNIFVWNLNE 559
Cdd:COG2319   289 GGVNSVAFSP-----D-GKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTL-ASGSDDGTVRLWDLAT 361
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 1734329663 560 dvEGPVARLRagaeGESVYMNRLIWSPDGKHVFVGDDEGRVHMYDVR 606
Cdd:COG2319   362 --GELLRTLT----GHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
378-607 8.65e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.17  E-value: 8.65e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734329663 378 QAHTYTVSCLAVVGTKNahNFVSLSRDGRICSWNVDnltqpvDGKELMTKEGkaasatrmsfPIGEMQTFVVGTDTGEIL 457
Cdd:cd00200     6 KGHTGGVTCVAFSPDGK--LLATGSGDGTIKVWDLE------TGELLRTLKG----------HTGPVRDVAASADGTYLA 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734329663 458 AASRNGA-------DPAVIKTdvcYKGHSGTLTGIEFHRASgvvdfsHLFISSSHDWTVKLWSTKDANLKFSFESHPDLV 530
Cdd:cd00200    68 SGSSDKTirlwdleTGECVRT---LTGHTSYVSSVAFSPDG------RILSSSSRDKTIKVWDVETGKCLTTLRGHTDWV 138
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1734329663 531 LDVAWSPVHPAVFASiDADGNIFVWNLNEdvEGPVARLragaEGESVYMNRLIWSPDGKHVFVGDDEGRVHMYDVRE 607
Cdd:cd00200   139 NSVAFSPDGTFVASS-SQDGTIKLWDLRT--GKCVATL----TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST 208
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
518-556 1.77e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 1.77e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1734329663  518 NLKFSFESHPDLVLDVAWSPVHPaVFASIDADGNIFVWN 556
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGK-YLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
253-606 1.93e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 109.23  E-value: 1.93e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734329663 253 DPYEKAIASDDLLHLAQVYQDETWTAKRL-------VTGMAFSehyPD---LLAVSYGpcdipneppGVIVVWNTKSKRM 322
Cdd:COG2319    87 SPDGRLLASASADGTVRLWDLATGLLLRTltghtgaVRSVAFS---PDgktLASGSAD---------GTVRLWDLATGKL 154
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734329663 323 TAEFIVYcQSEIQSVAFARfHAHLLLAGCESGQICVWDnrLTSRKLPinrspLTTQAHTYTVSCLAVvgTKNAHNFVSLS 402
Cdd:COG2319   155 LRTLTGH-SGAVTSVAFSP-DGKLLASGSDDGTVRLWD--LATGKLL-----RTLTGHTGAVRSVAF--SPDGKLLASGS 223
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734329663 403 RDGRICSWNVDNltqpvdGKELMTKEGKAASATRMSF-PIGemQTFVVGTDTGEIlaasR--NGADPAVIKTdvcYKGHS 479
Cdd:COG2319   224 ADGTVRLWDLAT------GKLLRTLTGHSGSVRSVAFsPDG--RLLASGSADGTV----RlwDLATGELLRT---LTGHS 288
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734329663 480 GTLTGIEFHRasgvvDfSHLFISSSHDWTVKLWSTKDANLKFSFESHPDLVLDVAWSPVHPAVfASIDADGNIFVWNLNE 559
Cdd:COG2319   289 GGVNSVAFSP-----D-GKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTL-ASGSDDGTVRLWDLAT 361
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 1734329663 560 dvEGPVARLRagaeGESVYMNRLIWSPDGKHVFVGDDEGRVHMYDVR 606
Cdd:COG2319   362 --GELLRTLT----GHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
332-625 2.38e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 102.68  E-value: 2.38e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734329663 332 SEIQSVAFARfHAHLLLAGCESGQICVWDnrltsrkLPINRSPLTTQAHTYTVSCLAVvgTKNAHNFVSLSRDGRICSWN 411
Cdd:COG2319    79 AAVLSVAFSP-DGRLLASASADGTVRLWD-------LATGLLLRTLTGHTGAVRSVAF--SPDGKTLASGSADGTVRLWD 148
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734329663 412 VDnltqpvDGKELMTKEGKAASATRMSF-PIGemQTFVVGTDTGEIlaasR--NGADPAVIKTdvcYKGHSGTLTGIEFH 488
Cdd:COG2319   149 LA------TGKLLRTLTGHSGAVTSVAFsPDG--KLLASGSDDGTV----RlwDLATGKLLRT---LTGHTGAVRSVAFS 213
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734329663 489 RasgvvDfSHLFISSSHDWTVKLWSTKDANLKFSFESHPDLVLDVAWSPvHPAVFASIDADGNIFVWNLNedvEGPVARL 568
Cdd:COG2319   214 P-----D-GKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLA---TGELLRT 283
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1734329663 569 RAGAEGEsvyMNRLIWSPDGKHVFVGDDEGRVHMYDV--RESLYVLKSEEWNRFARVLS 625
Cdd:COG2319   284 LTGHSGG---VNSVAFSPDGKLLASGSDDGTVRLWDLatGKLLRTLTGHTGAVRSVAFS 339
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
378-607 8.65e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.17  E-value: 8.65e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734329663 378 QAHTYTVSCLAVVGTKNahNFVSLSRDGRICSWNVDnltqpvDGKELMTKEGkaasatrmsfPIGEMQTFVVGTDTGEIL 457
Cdd:cd00200     6 KGHTGGVTCVAFSPDGK--LLATGSGDGTIKVWDLE------TGELLRTLKG----------HTGPVRDVAASADGTYLA 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734329663 458 AASRNGA-------DPAVIKTdvcYKGHSGTLTGIEFHRASgvvdfsHLFISSSHDWTVKLWSTKDANLKFSFESHPDLV 530
Cdd:cd00200    68 SGSSDKTirlwdleTGECVRT---LTGHTSYVSSVAFSPDG------RILSSSSRDKTIKVWDVETGKCLTTLRGHTDWV 138
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1734329663 531 LDVAWSPVHPAVFASiDADGNIFVWNLNEdvEGPVARLragaEGESVYMNRLIWSPDGKHVFVGDDEGRVHMYDVRE 607
Cdd:cd00200   139 NSVAFSPDGTFVASS-SQDGTIKLWDLRT--GKCVATL----TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST 208
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
282-604 1.77e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 89.32  E-value: 1.77e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734329663 282 VTGMAFSEHyPDLLAVSYGpcDipneppGVIVVWNTKskrmTAEFIVYCQSEIQSVAFARFHAH--LLLAGCESGQICVW 359
Cdd:cd00200    12 VTCVAFSPD-GKLLATGSG--D------GTIKVWDLE----TGELLRTLKGHTGPVRDVAASADgtYLASGSSDKTIRLW 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734329663 360 DnrLTSRKLPInrsplTTQAHTYTVSCLAVvgTKNAHNFVSLSRDGRICSWNVDNltqpvdGKELMTKEGKAASATRMSF 439
Cdd:cd00200    79 D--LETGECVR-----TLTGHTSYVSSVAF--SPDGRILSSSSRDKTIKVWDVET------GKCLTTLRGHTDWVNSVAF 143
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734329663 440 PigEMQTFVVGtdtgeilaASRNGA----DPAVIKTDVCYKGHSGTLTGIEFHRASGvvdfshLFISSSHDWTVKLWSTK 515
Cdd:cd00200   144 S--PDGTFVAS--------SSQDGTiklwDLRTGKCVATLTGHTGEVNSVAFSPDGE------KLLSSSSDGTIKLWDLS 207
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734329663 516 DANLKFSFESHPDLVLDVAWSPvHPAVFASIDADGNIFVWNLNEDVegPVARLRAGAEgeSVYmnRLIWSPDGKHVFVGD 595
Cdd:cd00200   208 TGKCLGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVWDLRTGE--CVQTLSGHTN--SVT--SLAWSPDGKRLASGS 280

                  ....*....
gi 1734329663 596 DEGRVHMYD 604
Cdd:cd00200   281 ADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
332-606 1.18e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 80.84  E-value: 1.18e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734329663 332 SEIQSVAFARfHAHLLLAGCESGQICVWDnrltsrkLPINRSPLTTQAHTYTVSCLAVVGtkNAHNFVSLSRDGRICSWN 411
Cdd:cd00200    10 GGVTCVAFSP-DGKLLATGSGDGTIKVWD-------LETGELLRTLKGHTGPVRDVAASA--DGTYLASGSSDKTIRLWD 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734329663 412 VDNltqpvdGKELMTKEGKAASATRMSFpigemqtfvvgTDTGEILAASrnGADPAV----IKTDVC---YKGHSGTLTG 484
Cdd:cd00200    80 LET------GECVRTLTGHTSYVSSVAF-----------SPDGRILSSS--SRDKTIkvwdVETGKClttLRGHTDWVNS 140
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734329663 485 IEFHRASGVVdfshlfISSSHDWTVKLWSTKDANLKFSFESHPDLVLDVAWSPVHPAVFASIDaDGNIFVWNLNEDVEgp 564
Cdd:cd00200   141 VAFSPDGTFV------ASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSS-DGTIKLWDLSTGKC-- 211
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1734329663 565 VARLRagaeGESVYMNRLIWSPDGKHVFVGDDEGRVHMYDVR 606
Cdd:cd00200   212 LGTLR----GHENGVNSVAFSPDGYLLASGSEDGTIRVWDLR 249
WD40 COG2319
WD40 repeat [General function prediction only];
282-516 1.66e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 72.64  E-value: 1.66e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734329663 282 VTGMAFSehyPD--LLAVSYGPcdipneppGVIVVWNTKSKRMTAEFIVYcQSEIQSVAFARfHAHLLLAGCESGQICVW 359
Cdd:COG2319   207 VRSVAFS---PDgkLLASGSAD--------GTVRLWDLATGKLLRTLTGH-SGSVRSVAFSP-DGRLLASGSADGTVRLW 273
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734329663 360 DnrLTSRKLPinrspLTTQAHTYTVSCLAVvgTKNAHNFVSLSRDGRICSWNVDnltqpvDGKELMTKEGKAASATRMSF 439
Cdd:COG2319   274 D--LATGELL-----RTLTGHSGGVNSVAF--SPDGKLLASGSDDGTVRLWDLA------TGKLLRTLTGHTGAVRSVAF 338
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1734329663 440 -PIGemQTFVVGTDTGEILAasRNGADPAVIKTdvcYKGHSGTLTGIEFHRASgvvdfsHLFISSSHDWTVKLWSTKD 516
Cdd:COG2319   339 sPDG--KTLASGSDDGTVRL--WDLATGELLRT---LTGHTGAVTSVAFSPDG------RTLASGSADGTVRLWDLAT 403
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
532-620 2.19e-05

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 47.73  E-value: 2.19e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734329663  532 DVAWSP----VhpaVFASiDADG--NIFVWNLNEdvEGPVARLragAEGESVYMNRLIWSPDGKHVFVGDDEGRVHMYDV 605
Cdd:COG4946    347 LPAWSPdgksI---AYFS-DASGeyELYIAPADG--SGEPKQL---TLGDLGRVFNPVWSPDGKKIAFTDNRGRLWVVDL 417
                           90       100
                   ....*....|....*....|
gi 1734329663  606 -----REslyVLKSEEWNRF 620
Cdd:COG4946    418 asgkvRK---VDTDGYGDGI 434
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
518-556 1.77e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 1.77e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1734329663  518 NLKFSFESHPDLVLDVAWSPVHPaVFASIDADGNIFVWN 556
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGK-YLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
519-606 5.15e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 39.24  E-value: 5.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734329663 519 LKFSFESHPDLVLDVAWSPVHPaVFASIDADGNIFVWNLNEDVegPVARLragaEGESVYMNRLIWSPDGKHVFVGDDEG 598
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGK-LLATGSGDGTIKVWDLETGE--LLRTL----KGHTGPVRDVAASADGTYLASGSSDK 73

                  ....*...
gi 1734329663 599 RVHMYDVR 606
Cdd:cd00200    74 TIRLWDLE 81
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
475-513 7.01e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.60  E-value: 7.01e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1734329663  475 YKGHSGTLTGIEFHrasgvvDFSHLFISSSHDWTVKLWS 513
Cdd:smart00320   8 LKGHTGPVTSVAFS------PDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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