NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1734340008|ref|NP_001359992|]
View 

SOCS box domain-containing protein [Caenorhabditis elegans]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
6-291 5.62e-26

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 106.96  E-value: 5.62e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008   6 DDFESQSQLQRALADKITNYAPIEEIRYILLRGAQVDGQVTAGLTPLHYACYINYQAAAKLLLNLGAKVQAVDNIGCSAL 85
Cdd:COG0666    12 LAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008  86 HLCAEHGHYRMIKLLLQYMKVVEQyetpefragdkypQRENVDEPLRLAIKNGHYDCARLLLTNGANANAIYFDGpeitq 165
Cdd:COG0666    92 HAAARNGDLEIVKLLLEAGADVNA-------------RDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDG----- 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 166 VSPL-------DTNFLELLLEFGADPNVFDRKGLTPIMKACRLRDkgIEAIRILLKYGADINKlcpERQDFRSALHFALL 238
Cdd:COG0666   154 NTPLhlaaangNLEIVKLLLEAGADVNARDNDGETPLHLAAENGH--LEIVKLLLEAGADVNA---KDNDGKTALDLAAE 228

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1734340008 239 SGNHDLVKFMIANGSNVNMDEKYEKpSPIDIAVLKDDPHLLKIVLDAGANPNA 291
Cdd:COG0666   229 NGNLEIVKLLLEAGADLNAKDKDGL-TALLLAAAAGAALIVKLLLLALLLLAA 280
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 424-465 5.19e-13

suppressors of cytokine signalling; suppressors of cytokine signalling


:

Pssm-ID: 128549  Cd Length: 43  Bit Score: 63.08  E-value: 5.19e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1734340008  424 SERAKNPHSLQHLCRIQIRDTVQTSEYKTLPIPEYLKAYLLG 465
Cdd:smart00253   1 LPRPSNVPSLQHLCRFTIRRCTRTDQIKTLPLPPKLKDYLSY 42
PHA03100 super family cl39094
ankyrin repeat protein; Provisional
 243-366 2.20e-12

ankyrin repeat protein; Provisional


The actual alignment was detected with superfamily member PHA03100:

Pssm-ID: 476869 [Multi-domain]  Cd Length: 422  Bit Score: 68.54  E-value: 2.20e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 243 DLVKFMIANGSNVNM-DEKYEKPSPI---DIAVLKDDPHLLKIVLDAGANPNAVHTYIGSCLHLASCSSLlNQYQIVELL 318
Cdd:PHA03100   49 DVVKILLDNGADINSsTKNNSTPLHYlsnIKYNLTDVKEIVKLLLEYGANVNAPDNNGITPLLYAISKKS-NSYSIVEYL 127

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1734340008 319 LEHGADMNLqhqfpDGSRLKSPFVEYFRSNDsIDAKVVKLFITHGAKV 366
Cdd:PHA03100  128 LDNGANVNI-----KNSDGENLLHLYLESNK-IDLKILKLLIDKGVDI 169
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
6-291 5.62e-26

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 106.96  E-value: 5.62e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008   6 DDFESQSQLQRALADKITNYAPIEEIRYILLRGAQVDGQVTAGLTPLHYACYINYQAAAKLLLNLGAKVQAVDNIGCSAL 85
Cdd:COG0666    12 LAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008  86 HLCAEHGHYRMIKLLLQYMKVVEQyetpefragdkypQRENVDEPLRLAIKNGHYDCARLLLTNGANANAIYFDGpeitq 165
Cdd:COG0666    92 HAAARNGDLEIVKLLLEAGADVNA-------------RDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDG----- 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 166 VSPL-------DTNFLELLLEFGADPNVFDRKGLTPIMKACRLRDkgIEAIRILLKYGADINKlcpERQDFRSALHFALL 238
Cdd:COG0666   154 NTPLhlaaangNLEIVKLLLEAGADVNARDNDGETPLHLAAENGH--LEIVKLLLEAGADVNA---KDNDGKTALDLAAE 228

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1734340008 239 SGNHDLVKFMIANGSNVNMDEKYEKpSPIDIAVLKDDPHLLKIVLDAGANPNA 291
Cdd:COG0666   229 NGNLEIVKLLLEAGADLNAKDKDGL-TALLLAAAAGAALIVKLLLLALLLLAA 280
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 64-366 1.02e-20

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 95.13  E-value: 1.02e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008  64 AKLLLNLGAKVQAVDNIGCSALHLCAEHGHYRMIKLLLQY-----MKVVEQYETPEFRAGDK--------YPQRENV--- 127
Cdd:PHA02876  161 AEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYgadvnIIALDDLSVLECAVDSKnidtikaiIDNRSNInkn 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 128 DEPLRLAIKNGHYDCARLLLTNGANANAI--YFDGP-EITQVSPLDTNFLELLLEFGADPNVFDRKGLTPIMKACRlRDK 204
Cdd:PHA02876  241 DLSLLKAIRNEDLETSLLLYDAGFSVNSIddCKNTPlHHASQAPSLSRLVPKLLERGADVNAKNIKGETPLYLMAK-NGY 319

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 205 GIEAIRILLKYGADINKlcpERQDFRSALHFA-LLSGNHDLVKFMIANGSNVNMDEKYEKpSPIDIAVLKDDPHLLKIVL 283
Cdd:PHA02876  320 DTENIRTLIMLGADVNA---ADRLYITPLHQAsTLDRNKDIVITLLELGANVNARDYCDK-TPIHYAAVRNNVVIINTLL 395

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 284 DAGANPNAVHTYIGSCLHLASCSSllNQYQIVELLLEHGADMNLQHQFpdgsrLKSPFveYFRSNDSIDAKVVKLFITHG 363
Cdd:PHA02876  396 DYGADIEALSQKIGTALHFALCGT--NPYMSVKTLIDRGANVNSKNKD-----LSTPL--HYACKKNCKLDVIEMLLDNG 466


                  ...
gi 1734340008 364 AKV 366
Cdd:PHA02876  467 ADV 469
Ank_2 pfam12796
Ankyrin repeats (3 copies);
52-155 2.16e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 71.30  E-value: 2.16e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008  52 LHYACYINYQAAAKLLLNLGAKVQAVDNIGCSALHLCAEHGHYRMIKLLLQYMKVveqyetpefragDKYPQRENvdePL 131
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV------------NLKDNGRT---AL 65

                          90       100
                  ....*....|....*....|....
gi 1734340008 132 RLAIKNGHYDCARLLLTNGANANA 155
Cdd:pfam12796  66 HYAARSGHLEIVKLLLEKGADINV 89
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 424-465 5.19e-13

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 63.08  E-value: 5.19e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1734340008  424 SERAKNPHSLQHLCRIQIRDTVQTSEYKTLPIPEYLKAYLLG 465
Cdd:smart00253   1 LPRPSNVPSLQHLCRFTIRRCTRTDQIKTLPLPPKLKDYLSY 42
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 243-366 2.20e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 68.54  E-value: 2.20e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 243 DLVKFMIANGSNVNM-DEKYEKPSPI---DIAVLKDDPHLLKIVLDAGANPNAVHTYIGSCLHLASCSSLlNQYQIVELL 318
Cdd:PHA03100   49 DVVKILLDNGADINSsTKNNSTPLHYlsnIKYNLTDVKEIVKLLLEYGANVNAPDNNGITPLLYAISKKS-NSYSIVEYL 127

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1734340008 319 LEHGADMNLqhqfpDGSRLKSPFVEYFRSNDsIDAKVVKLFITHGAKV 366
Cdd:PHA03100  128 LDNGANVNI-----KNSDGENLLHLYLESNK-IDLKILKLLIDKGVDI 169
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
211-394 1.83e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 64.59  E-value: 1.83e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 211 ILLKYGADINKLCPERQDFRSALHFALLSGNHDLVKFMIANGSNVNMDEKYEKPSPIDIAVLKDDPHLLKIVLDAGANPN 290
Cdd:COG0666    35 LLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVN 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 291 AVHTYIGSCLHLASCSsllNQYQIVELLLEHGADMNLQhqfpdGSRLKSPFVEYFRSNdsiDAKVVKLFITHGAKVVMRN 370
Cdd:COG0666   115 ARDKDGETPLHLAAYN---GNLEIVKLLLEAGADVNAQ-----DNDGNTPLHLAAANG---NLEIVKLLLEAGADVNARD 183

                         170       180
                  ....*....|....*....|....
gi 1734340008 371 PLHdcrgqlRNVLKLAALQNQPEV 394
Cdd:COG0666   184 NDG------ETPLHLAAENGHLEI 201
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 428-464 8.70e-07

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 45.56  E-value: 8.70e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1734340008 428 KNPHSLQHLCRIQIRDTVQT---SEYKTLPIPEYLKAYLL 464
Cdd:cd03716     1 STPRSLQHLCRLAIRRCLGRrrlELIKKLPLPPRLKDYLL 40
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 429-464 3.89e-06

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 43.31  E-value: 3.89e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1734340008 429 NPHSLQHLCRIQIRDTVQTSEYK---TLPIPEYLKAYLL 464
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGaidKLPLPPLLKDYLL 39
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 189-331 1.92e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 46.93  E-value: 1.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 189 RKGLTPIMKACRLRDkgIEAIRILLKygadinklCPeRQDF-------RSALHFALLSGNHDLVKFMIANGSN-VNM--- 257
Cdd:cd22192    15 RISESPLLLAAKEND--VQAIKKLLK--------CP-SCDLfqrgalgETALHVAALYDNLEAAVVLMEAAPElVNEpmt 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 258 DEKYEKPSPIDIAVLKDDPHLLKIVLDAGA---NPNAVHTYI---GSCL-----HLASCSSLLNQYQIVELLLEHGADMN 326
Cdd:cd22192    84 SDLYQGETALHIAVVNQNLNLVRELIARGAdvvSPRATGTFFrpgPKNLiyygeHPLSFAACVGNEEIVRLLIEHGADIR 163


                  ....*
gi 1734340008 327 LQHQF 331
Cdd:cd22192   164 AQDSL 168
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 59-155 2.66e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 43.53  E-value: 2.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008  59 NYQAAAKLLLNLGAKVQavdnIGCSALHLCAEhGHYRMIKLLLQYMKVVEQYETPEFRAGDKYPQRENVDE-PLRLAIKN 137
Cdd:TIGR00870  64 ENLELTELLLNLSCRGA----VGDTLLHAISL-EYVDAVEAILLHLLAAFRKSGPLELANDQYTSEFTPGItALHLAAHR 138

                          90
                  ....*....|....*...
gi 1734340008 138 GHYDCARLLLTNGANANA 155
Cdd:TIGR00870 139 QNYEIVKLLLERGASVPA 156
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 298-328 2.65e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 35.34  E-value: 2.65e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1734340008 298 SCLHLASCSSllNQYQIVELLLEHGADMNLQ 328
Cdd:pfam00023   4 TPLHLAAGRR--GNLEIVKLLLSKGADVNAR 32
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 81-108 3.28e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.87  E-value: 3.28e-03
                           10        20
                   ....*....|....*....|....*...
gi 1734340008   81 GCSALHLCAEHGHYRMIKLLLQYMKVVE 108
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADIN 29
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
6-291 5.62e-26

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 106.96  E-value: 5.62e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008   6 DDFESQSQLQRALADKITNYAPIEEIRYILLRGAQVDGQVTAGLTPLHYACYINYQAAAKLLLNLGAKVQAVDNIGCSAL 85
Cdd:COG0666    12 LAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008  86 HLCAEHGHYRMIKLLLQYMKVVEQyetpefragdkypQRENVDEPLRLAIKNGHYDCARLLLTNGANANAIYFDGpeitq 165
Cdd:COG0666    92 HAAARNGDLEIVKLLLEAGADVNA-------------RDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDG----- 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 166 VSPL-------DTNFLELLLEFGADPNVFDRKGLTPIMKACRLRDkgIEAIRILLKYGADINKlcpERQDFRSALHFALL 238
Cdd:COG0666   154 NTPLhlaaangNLEIVKLLLEAGADVNARDNDGETPLHLAAENGH--LEIVKLLLEAGADVNA---KDNDGKTALDLAAE 228

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1734340008 239 SGNHDLVKFMIANGSNVNMDEKYEKpSPIDIAVLKDDPHLLKIVLDAGANPNA 291
Cdd:COG0666   229 NGNLEIVKLLLEAGADLNAKDKDGL-TALLLAAAAGAALIVKLLLLALLLLAA 280
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
6-263 2.41e-25

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 105.42  E-value: 2.41e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008   6 DDFESQSQLQRALADKITNYAPIEEIRYILLRGAQVDGQVTAGLTPLHYACYINYQAAAKLLLNLGAKVQAVDNIGCSAL 85
Cdd:COG0666    45 LALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPL 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008  86 HLCAEHGHYRMIKLLLQymkvveqyetpefRAGDKYPQRENVDEPLRLAIKNGHYDCARLLLTNGANANAIYFDGpeitq 165
Cdd:COG0666   125 HLAAYNGNLEIVKLLLE-------------AGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDG----- 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 166 VSPL-------DTNFLELLLEFGADPNVFDRKGLTPIMKACRLRDKGIeaIRILLKYGADINKlcpERQDFRSALHFALL 238
Cdd:COG0666   187 ETPLhlaaengHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEI--VKLLLEAGADLNA---KDKDGLTALLLAAA 261

                         250       260
                  ....*....|....*....|....*
gi 1734340008 239 SGNHDLVKFMIANGSNVNMDEKYEK 263
Cdd:COG0666   262 AGAALIVKLLLLALLLLAAALLDLL 286
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
117-327 1.45e-23

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 100.41  E-value: 1.45e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 117 AGDKYPQRENVDEPLRLAIKNGHYDCARLLLTNGANANAIYFDG--PEITQVSPLDTNFLELLLEFGADPNVFDRKGLTP 194
Cdd:COG0666    44 LLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGntLLHAAARNGDLEIVKLLLEAGADVNARDKDGETP 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 195 IMKACRLRDkgIEAIRILLKYGADINKLCPERQdfrSALHFALLSGNHDLVKFMIANGSNVNMDEKYEKpSPIDIAVLKD 274
Cdd:COG0666   124 LHLAAYNGN--LEIVKLLLEAGADVNAQDNDGN---TPLHLAAANGNLEIVKLLLEAGADVNARDNDGE-TPLHLAAENG 197

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1734340008 275 DPHLLKIVLDAGANPNAVHTYIGSCLHLAscsSLLNQYQIVELLLEHGADMNL 327
Cdd:COG0666   198 HLEIVKLLLEAGADVNAKDNDGKTALDLA---AENGNLEIVKLLLEAGADLNA 247
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 64-366 1.02e-20

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 95.13  E-value: 1.02e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008  64 AKLLLNLGAKVQAVDNIGCSALHLCAEHGHYRMIKLLLQY-----MKVVEQYETPEFRAGDK--------YPQRENV--- 127
Cdd:PHA02876  161 AEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYgadvnIIALDDLSVLECAVDSKnidtikaiIDNRSNInkn 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 128 DEPLRLAIKNGHYDCARLLLTNGANANAI--YFDGP-EITQVSPLDTNFLELLLEFGADPNVFDRKGLTPIMKACRlRDK 204
Cdd:PHA02876  241 DLSLLKAIRNEDLETSLLLYDAGFSVNSIddCKNTPlHHASQAPSLSRLVPKLLERGADVNAKNIKGETPLYLMAK-NGY 319

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 205 GIEAIRILLKYGADINKlcpERQDFRSALHFA-LLSGNHDLVKFMIANGSNVNMDEKYEKpSPIDIAVLKDDPHLLKIVL 283
Cdd:PHA02876  320 DTENIRTLIMLGADVNA---ADRLYITPLHQAsTLDRNKDIVITLLELGANVNARDYCDK-TPIHYAAVRNNVVIINTLL 395

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 284 DAGANPNAVHTYIGSCLHLASCSSllNQYQIVELLLEHGADMNLQHQFpdgsrLKSPFveYFRSNDSIDAKVVKLFITHG 363
Cdd:PHA02876  396 DYGADIEALSQKIGTALHFALCGT--NPYMSVKTLIDRGANVNSKNKD-----LSTPL--HYACKKNCKLDVIEMLLDNG 466


                  ...
gi 1734340008 364 AKV 366
Cdd:PHA02876  467 ADV 469
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
143-370 4.47e-17

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 81.54  E-value: 4.47e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 143 ARLLLTNGANANAIYFDGPEITQVSPLDTNFLELLLEFGADPNVFDRKGLTPIMKACRLRDKGIEAIRILLKYGADINKl 222
Cdd:COG0666     4 LLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINA- 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 223 cpERQDFRSALHFALLSGNHDLVKFMIANGSNVNMDEKYEKpSPIDIAVLKDDPHLLKIVLDAGANPNAVHTYIGSCLHL 302
Cdd:COG0666    83 --KDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGE-TPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHL 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1734340008 303 ASCSsllNQYQIVELLLEHGADMNLQHqfPDGsrlKSPFVEYFRSNdsiDAKVVKLFITHGAKVVMRN 370
Cdd:COG0666   160 AAAN---GNLEIVKLLLEAGADVNARD--NDG---ETPLHLAAENG---HLEIVKLLLEAGADVNAKD 216
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 24-261 7.56e-17

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 82.41  E-value: 7.56e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008  24 NYAPIEEIRYILLRGAQVDGQVTAGLTPLHYACYINYQAA-----AKLLLNLGAKVQAVDNIGCSALHLCAEH--GHYRM 96
Cdd:PHA03100   44 EARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNLTdvkeiVKLLLEYGANVNAPDNNGITPLLYAISKksNSYSI 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008  97 IKLLLQYMKVVEqyetpefragDKYPQRENvdePLRLAIKNGHYD--CARLLLTNGANANAIyfdgpeitqvspldtNFL 174
Cdd:PHA03100  124 VEYLLDNGANVN----------IKNSDGEN---LLHLYLESNKIDlkILKLLIDKGVDINAK---------------NRV 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 175 ELLLEFGADPNVFDRKGLTPIMKACRLRDkgIEAIRILLKYGADINkLCPERQDfrSALHFALLSGNHDLVKFMIANGSN 254
Cdd:PHA03100  176 NYLLSYGVPINIKDVYGFTPLHYAVYNNN--PEFVKYLLDLGANPN-LVNKYGD--TPLHIAILNNNKEIFKLLLNNGPS 250


                  ....*..
gi 1734340008 255 VNMDEKY 261
Cdd:PHA03100  251 IKTIIET 257
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 100-327 9.18e-17

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 81.96  E-value: 9.18e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 100 LLQYMkvVEQYETPEFRAGDKYpqrenvdEPLRLAIKNGHYDCARLLLTNGANANAIYfdgPEITqvSPL-------DTN 172
Cdd:PHA02875   17 IARRL--LDIGINPNFEIYDGI-------SPIKLAMKFRDSEAIKLLMKHGAIPDVKY---PDIE--SELhdaveegDVK 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 173 FLELLLEFGADPN-VFDRKGLTPIMKACRLrdKGIEAIRILLKYGADINKlcpERQDFRSALHFALLSGNHDLVKFMIAN 251
Cdd:PHA02875   83 AVEELLDLGKFADdVFYKDGMTPLHLATIL--KKLDIMKLLIARGADPDI---PNTDKFSPLHLAVMMGDIKGIELLIDH 157

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1734340008 252 GSNVNMDEKYeKPSPIDIAVLKDDPHLLKIVLDAGANPNavhtYIGS--CLHLASCSSLLNQYQIVELLLEHGADMNL 327
Cdd:PHA02875  158 KACLDIEDCC-GCTPLIIAMAKGDIAICKMLLDSGANID----YFGKngCVAALCYAIENNKIDIVRLFIKRGADCNI 230
Ank_2 pfam12796
Ankyrin repeats (3 copies);
52-155 2.16e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 71.30  E-value: 2.16e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008  52 LHYACYINYQAAAKLLLNLGAKVQAVDNIGCSALHLCAEHGHYRMIKLLLQYMKVveqyetpefragDKYPQRENvdePL 131
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV------------NLKDNGRT---AL 65

                          90       100
                  ....*....|....*....|....
gi 1734340008 132 RLAIKNGHYDCARLLLTNGANANA 155
Cdd:pfam12796  66 HYAARSGHLEIVKLLLEKGADINV 89
PHA03095 PHA03095
ankyrin-like protein; Provisional
 17-327 1.36e-14

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 75.83  E-value: 1.36e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008  17 ALADKITNYAP--IEEIRYILLRGAQVDGQVTAGLTPLHYacYINYQAAA-----KLLLNLGAKVQAVDNIGCSALHLCA 89
Cdd:PHA03095   14 ALYDYLLNASNvtVEEVRRLLAAGADVNFRGEYGKTPLHL--YLHYSSEKvkdivRLLLEAGADVNAPERCGFTPLHLYL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008  90 EHGH-YRMIKLLLqymkvveqyetpefRAGdkypqrENVDEplrlaiKNGhydcarllltNGANANAIYFDGPEItqvsp 168
Cdd:PHA03095   92 YNATtLDVIKLLI--------------KAG------ADVNA------KDK----------VGRTPLHVYLSGFNI----- 130

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 169 lDTNFLELLLEFGADPNVFDRKGLTPImkACRLRDKG--IEAIRILLKYGADI--NKLCperqdFRSALHFALLS--GNH 242
Cdd:PHA03095  131 -NPKVIRLLLRKGADVNALDLYGMTPL--AVLLKSRNanVELLRLLIDAGADVyaVDDR-----FRSLLHHHLQSfkPRA 202

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 243 DLVKFMIANGSNVNMDEKYEKPSPIDIAVLKDDPHLLKI-VLDAGANPNAVHTYIGSCLHLASCSsllNQYQIVELLLEH 321
Cdd:PHA03095  203 RIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKRSLVLpLLIAGISINARNRYGQTPLHYAAVF---NNPRACRRLIAL 279


                  ....*.
gi 1734340008 322 GADMNL 327
Cdd:PHA03095  280 GADINA 285
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 130-326 1.55e-14

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 75.09  E-value: 1.55e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 130 PLRLAIKNGHYDCARLLLTNGANANAIYFD-------GPEITQVSPLDTNFLELLLEFGADPNVFDRKGLTPIMKACRLR 202
Cdd:PHA03100   38 PLYLAKEARNIDVVKILLDNGADINSSTKNnstplhyLSNIKYNLTDVKEIVKLLLEYGANVNAPDNNGITPLLYAISKK 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 203 DKGIEAIRILLKYGADINklcPERQDFRSALHFALLSGNHDL--VKFMIANGSNVN-MDE-KY--EKPSPIDI------- 269
Cdd:PHA03100  118 SNSYSIVEYLLDNGANVN---IKNSDGENLLHLYLESNKIDLkiLKLLIDKGVDINaKNRvNYllSYGVPINIkdvygft 194

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1734340008 270 ----AVLKDDPHLLKIVLDAGANPNAVHTYIGSCLHLASCSSLLNqyqIVELLLEHGADMN 326
Cdd:PHA03100  195 plhyAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKE---IFKLLLNNGPSIK 252
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 49-326 2.36e-14

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 74.92  E-value: 2.36e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008  49 LTPLHYACYINYQAAAKLLLNLGAKVQAVDNIGCSALHL-CAEHGHYRMIKLLLQYMKVVEQYEtpeFRAgdkypqrenv 127
Cdd:PHA02878   38 FIPLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIiCKEPNKLGMKEMIRSINKCSVFYT---LVA---------- 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 128 depLRLAIKNGHYDCARLLLTNGANANA----IYFDgpEITQVSPLDTNFLELLLEFGADPNVFDR-KGLTPIMKACRLR 202
Cdd:PHA02878  105 ---IKDAFNNRNVEIFKIILTNRYKNIQtidlVYID--KKSKDDIIEAEITKLLLSYGADINMKDRhKGNTALHYATENK 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 203 DKGIeaIRILLKYGADINklCPERQDfRSALHFALLSGNHDLVKFMIANGSNVNMDEKYEKpSPIDIAVLK-DDPHLLKI 281
Cdd:PHA02878  180 DQRL--TELLLSYGANVN--IPDKTN-NSPLHHAVKHYNKPIVHILLENGASTDARDKCGN-TPLHISVGYcKDYDILKL 253

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1734340008 282 VLDAGANPNAVHTYIG-SCLHLAscsslLNQYQIVELLLEHGADMN 326
Cdd:PHA02878  254 LLEHGVDVNAKSYILGlTALHSS-----IKSERKLKLLLEYGADIN 294
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 424-465 5.19e-13

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 63.08  E-value: 5.19e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1734340008  424 SERAKNPHSLQHLCRIQIRDTVQTSEYKTLPIPEYLKAYLLG 465
Cdd:smart00253   1 LPRPSNVPSLQHLCRFTIRRCTRTDQIKTLPLPPKLKDYLSY 42
Ank_2 pfam12796
Ankyrin repeats (3 copies);
170-256 9.92e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 63.98  E-value: 9.92e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 170 DTNFLELLLEFGADPNVFDRKGLTPIMKACRLRDkgIEAIRILLKYgADINklcpERQDFRSALHFALLSGNHDLVKFMI 249
Cdd:pfam12796   9 NLELVKLLLENGADANLQDKNGRTALHLAAKNGH--LEIVKLLLEH-ADVN----LKDNGRTALHYAARSGHLEIVKLLL 81


                  ....*..
gi 1734340008 250 ANGSNVN 256
Cdd:pfam12796  82 EKGADIN 88
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 172-328 2.11e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 68.48  E-value: 2.11e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 172 NFLELLLEFGADPNVFDRKGLTPIMKACRLRDkgIEAIRILLKYGADINKLCPerqDFRSALHFALLSGNHDLVKFMIAN 251
Cdd:PHA02875   16 DIARRLLDIGINPNFEIYDGISPIKLAMKFRD--SEAIKLLMKHGAIPDVKYP---DIESELHDAVEEGDVKAVEELLDL 90

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1734340008 252 GSNVNmDEKYEKP-SPIDIAVLKDDPHLLKIVLDAGANPNAVHTYIGSCLHLASCSSLLNqyqIVELLLEHGADMNLQ 328
Cdd:PHA02875   91 GKFAD-DVFYKDGmTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIK---GIELLIDHKACLDIE 164
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 243-366 2.20e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 68.54  E-value: 2.20e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 243 DLVKFMIANGSNVNM-DEKYEKPSPI---DIAVLKDDPHLLKIVLDAGANPNAVHTYIGSCLHLASCSSLlNQYQIVELL 318
Cdd:PHA03100   49 DVVKILLDNGADINSsTKNNSTPLHYlsnIKYNLTDVKEIVKLLLEYGANVNAPDNNGITPLLYAISKKS-NSYSIVEYL 127

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1734340008 319 LEHGADMNLqhqfpDGSRLKSPFVEYFRSNDsIDAKVVKLFITHGAKV 366
Cdd:PHA03100  128 LDNGANVNI-----KNSDGENLLHLYLESNK-IDLKILKLLIDKGVDI 169
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 28-295 5.24e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 67.60  E-value: 5.24e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008  28 IEEIRYILLRGAQVDGQVTAGLTPLHYACYINYQAAAKLLLNLGAKvqavDNIGcSALHLCAEHGHYRMIKLllqYMKVV 107
Cdd:PHA02878   50 LDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSINK----CSVF-YTLVAIKDAFNNRNVEI---FKIIL 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 108 EQYETPEFRAGDKYPQRENVDEPLRLAIknghydcARLLLTNGANANAIyfdgPEITQVSPL-------DTNFLELLLEF 180
Cdd:PHA02878  122 TNRYKNIQTIDLVYIDKKSKDDIIEAEI-------TKLLLSYGADINMK----DRHKGNTALhyatenkDQRLTELLLSY 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 181 GADPNVFDRKGLTPIMKACRLRDKGIeaIRILLKYGA--DINKLCPErqdfrSALHFALLS-GNHDLVKFMIANGSNVNM 257
Cdd:PHA02878  191 GANVNIPDKTNNSPLHHAVKHYNKPI--VHILLENGAstDARDKCGN-----TPLHISVGYcKDYDILKLLLEHGVDVNA 263

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1734340008 258 DEKYEKPSPIDIAVlkDDPHLLKIVLDAGANPNAVHTY 295
Cdd:PHA02878  264 KSYILGLTALHSSI--KSERKLKLLLEYGADINSLNSY 299
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 126-386 1.27e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 66.14  E-value: 1.27e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 126 NVDEPLRLAIKNGHYDCARLLLTNGANANaiyfdgpeITQVSPLDTNFLELLLEFGADPNVFDRKGLTPIMKACRLRDkg 205
Cdd:PHA02874   67 KIPHPLLTAIKIGAHDIIKLLIDNGVDTS--------ILPIPCIEKDMIKTILDCGIDVNIKDAELKTFLHYAIKKGD-- 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 206 IEAIRILLKYGADINKlcpERQDFRSALHFALLSGNHDLVKFMIANGSNVNMDEKYEKpSPIDIAVLKDDPHLLKIVLDA 285
Cdd:PHA02874  137 LESIKMLFEYGADVNI---EDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGE-SPLHNAAEYGDYACIKLLIDH 212

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 286 GANPNAVHTYIGSCLHLAscssLLNQYQIVELLLEHgADMNLQHQfpDGSrlkSPFveYFRSNDSIDAKVVKLFITHGAK 365
Cdd:PHA02874  213 GNHIMNKCKNGFTPLHNA----IIHNRSAIELLINN-ASINDQDI--DGS---TPL--HHAINPPCDIDIIDILLYHKAD 280

                         250       260
                  ....*....|....*....|.
gi 1734340008 366 VVMRnplhDCRGqlRNVLKLA 386
Cdd:PHA02874  281 ISIK----DNKG--ENPIDTA 295
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
211-394 1.83e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 64.59  E-value: 1.83e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 211 ILLKYGADINKLCPERQDFRSALHFALLSGNHDLVKFMIANGSNVNMDEKYEKPSPIDIAVLKDDPHLLKIVLDAGANPN 290
Cdd:COG0666    35 LLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVN 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 291 AVHTYIGSCLHLASCSsllNQYQIVELLLEHGADMNLQhqfpdGSRLKSPFVEYFRSNdsiDAKVVKLFITHGAKVVMRN 370
Cdd:COG0666   115 ARDKDGETPLHLAAYN---GNLEIVKLLLEAGADVNAQ-----DNDGNTPLHLAAANG---NLEIVKLLLEAGADVNARD 183

                         170       180
                  ....*....|....*....|....
gi 1734340008 371 PLHdcrgqlRNVLKLAALQNQPEV 394
Cdd:COG0666   184 NDG------ETPLHLAAENGHLEI 201
Ank_2 pfam12796
Ankyrin repeats (3 copies);
31-103 7.75e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 58.59  E-value: 7.75e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1734340008  31 IRYILLRGAQVDGQVTAGLTPLHYACYINYQAAAKLLLNLGAkvQAVDNIGCSALHLCAEHGHYRMIKLLLQY 103
Cdd:pfam12796  13 VKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD--VNLKDNGRTALHYAARSGHLEIVKLLLEK 83
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 29-220 3.52e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 61.90  E-value: 3.52e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008  29 EEIRYILLRGAQVDGQVTAGLTPLHYACYINYQAAAKLLLNLGAKVQAVDNIGCSALHLCAEHGHYRMIKLLLQ---YMK 105
Cdd:PHA02874  105 DMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEkgaYAN 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 106 VveqyetpefragdkypQRENVDEPLRLAIKNGHYDCARLLLTNGANANAIYFDGpeitqVSPLDTNFL------ELLLE 179
Cdd:PHA02874  185 V----------------KDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNG-----FTPLHNAIIhnrsaiELLIN 243

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1734340008 180 fGADPNVFDRKGLTPIMKACRLrDKGIEAIRILLKYGADIN 220
Cdd:PHA02874  244 -NASINDQDIDGSTPLHHAINP-PCDIDIIDILLYHKADIS 282
PHA03095 PHA03095
ankyrin-like protein; Provisional
 206-373 1.23e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 60.04  E-value: 1.23e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 206 IEAIRILLKYGADINKLCPErqdFRSALHFALLSGNH---DLVKFMIANGSNVNMDEKYeKPSPIDIAVLKDD-PHLLKI 281
Cdd:PHA03095   27 VEEVRRLLAAGADVNFRGEY---GKTPLHLYLHYSSEkvkDIVRLLLEAGADVNAPERC-GFTPLHLYLYNATtLDVIKL 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 282 VLDAGANPNAVHTYIGSCLHlASCSSLLNQYQIVELLLEHGADMNLQHQFpdgsrLKSPFVEYFRSNDsIDAKVVKLFIT 361
Cdd:PHA03095  103 LIKAGADVNAKDKVGRTPLH-VYLSGFNINPKVIRLLLRKGADVNALDLY-----GMTPLAVLLKSRN-ANVELLRLLID 175

                         170
                  ....*....|....*..
gi 1734340008 362 HGAKV-----VMRNPLH 373
Cdd:PHA03095  176 AGADVyavddRFRSLLH 192
Ank_4 pfam13637
Ankyrin repeats (many copies);
48-101 1.89e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 53.43  E-value: 1.89e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1734340008  48 GLTPLHYACYINYQAAAKLLLNLGAKVQAVDNIGCSALHLCAEHGHYRMIKLLL 101
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_2 pfam12796
Ankyrin repeats (3 copies);
233-328 1.06e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 52.43  E-value: 1.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 233 LHFALLSGNHDLVKFMIANGSNVNMDEKyEKPSPIDIAVLKDDPHLLKIVLDaGANPNAVhTYIGSCLHLASCSsllNQY 312
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDK-NGRTALHLAAKNGHLEIVKLLLE-HADVNLK-DNGRTALHYAARS---GHL 74

                          90
                  ....*....|....*.
gi 1734340008 313 QIVELLLEHGADMNLQ 328
Cdd:pfam12796  75 EIVKLLLEKGADINVK 90
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 34-325 1.27e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 57.38  E-value: 1.27e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008  34 ILLRGAQVDGQVTAGLTPLHYACYINYQAA-AKLLLNLGAKVQAVDNIGCSALHlcaehghyrmiklllqymkvveqyet 112
Cdd:PHA02876  293 LLERGADVNAKNIKGETPLYLMAKNGYDTEnIRTLIMLGADVNAADRLYITPLH-------------------------- 346

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 113 pefragdkypqrenvdeplrlaiknghydcarllltngananaiyfdgpeitQVSPLDTN--FLELLLEFGADPNVFDRK 190
Cdd:PHA02876  347 ----------------------------------------------------QASTLDRNkdIVITLLELGANVNARDYC 374

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 191 GLTPIMKACrLRDKgIEAIRILLKYGADINKLcpeRQDFRSALHFALLSGN-HDLVKFMIANGSNVNMDEKYEKpSPIDI 269
Cdd:PHA02876  375 DKTPIHYAA-VRNN-VVIINTLLDYGADIEAL---SQKIGTALHFALCGTNpYMSVKTLIDRGANVNSKNKDLS-TPLHY 448

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1734340008 270 AVLKD-DPHLLKIVLDAGANPNAVHTYIGSCLHLAscsslLNQYQIVELLLEHGADM 325
Cdd:PHA02876  449 ACKKNcKLDVIEMLLDNGADVNAINIQNQYPLLIA-----LEYHGIVNILLHYGAEL 500
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 20-213 1.70e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 56.43  E-value: 1.70e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008  20 DKITNYAPIEE--IRYILLRGAQVDGQV-TAGLTPLHYACYINYQAAAKLLLNLGAKVQAVDNIGCSALHLCAEHGHYRM 96
Cdd:PHA02878  137 DKKSKDDIIEAeiTKLLLSYGADINMKDrHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPI 216

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008  97 IKLLLQYMKVVEqyetpefrAGDKYPqrenvDEPLRLAIKN-GHYDCARLLLTNGANANA-IYFDGPEITQVSPLDTNFL 174
Cdd:PHA02878  217 VHILLENGASTD--------ARDKCG-----NTPLHISVGYcKDYDILKLLLEHGVDVNAkSYILGLTALHSSIKSERKL 283

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1734340008 175 ELLLEFGADPNVFDRKGLTPIMKACRLRdKGIEAIRILL 213
Cdd:PHA02878  284 KLLLEYGADINSLNSYKLTPLSSAVKQY-LCINIGRILI 321
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 126-325 1.97e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 56.13  E-value: 1.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 126 NVDE---PLRLAIKNGHYDCARLLLTNGANANAIYFDGPE--ITQVSPLDTNFLELLLEFGADPNVFdrkgltPImkacr 200
Cdd:PHA02874   31 SVDEtttPLIDAIRSGDAKIVELFIKHGADINHINTKIPHplLTAIKIGAHDIIKLLIDNGVDTSIL------PI----- 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 201 lRDKGIEAIRILLKYGADINKLCPERQDFrsaLHFALLSGNHDLVKFMIANGSNVNMdEKYEKPSPIDIAVLKDDPHLLK 280
Cdd:PHA02874  100 -PCIEKDMIKTILDCGIDVNIKDAELKTF---LHYAIKKGDLESIKMLFEYGADVNI-EDDNGCYPIHIAIKHNFFDIIK 174

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1734340008 281 IVLDAGANPNAVHTYIGSCLHLascSSLLNQYQIVELLLEHGADM 325
Cdd:PHA02874  175 LLLEKGAYANVKDNNGESPLHN---AAEYGDYACIKLLIDHGNHI 216
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 131-385 1.24e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 53.81  E-value: 1.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 131 LRLAIKNGHYDCARLLLTNGANANAIYFD---GPEITQVSPLDTNFLELLLEFGADPNVFDRKGLTPIMKACRLRDKGIe 207
Cdd:PHA02874    5 LRMCIYSGDIEAIEKIIKNKGNCINISVDettTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDI- 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 208 aIRILLKYGADINKLcperqdfrsalhfALLSGNHDLVKFMIANGSNVNMDEKYEKpSPIDIAVLKDDPHLLKIVLDAGA 287
Cdd:PHA02874   84 -IKLLIDNGVDTSIL-------------PIPCIEKDMIKTILDCGIDVNIKDAELK-TFLHYAIKKGDLESIKMLFEYGA 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 288 NPNAVHTYIGSCLHLASCSsllNQYQIVELLLEHGADMNLQHQFpdgsrLKSPF---VEYFrsndsiDAKVVKLFITHGA 364
Cdd:PHA02874  149 DVNIEDDNGCYPIHIAIKH---NFFDIIKLLLEKGAYANVKDNN-----GESPLhnaAEYG------DYACIKLLIDHGN 214

                         250       260
                  ....*....|....*....|....*.
gi 1734340008 365 KVVMR-----NPLHDCRGQLRNVLKL 385
Cdd:PHA02874  215 HIMNKckngfTPLHNAIIHNRSAIEL 240
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 428-464 8.70e-07

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 45.56  E-value: 8.70e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1734340008 428 KNPHSLQHLCRIQIRDTVQT---SEYKTLPIPEYLKAYLL 464
Cdd:cd03716     1 STPRSLQHLCRLAIRRCLGRrrlELIKKLPLPPRLKDYLL 40
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 429-464 1.18e-06

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 45.15  E-value: 1.18e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1734340008 429 NPHSLQHLCRIQIRDTVQTSEY---KTLPIPEYLKAYLL 464
Cdd:cd03587     1 NPRSLQHLCRLAIRRCLGKRRLdliDKLPLPPRLKDYLL 39
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 29-219 1.55e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 50.83  E-value: 1.55e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008  29 EEIRYILLRGAQVDGQVTAGLTPLHYACYIN-YQAAAKLLLNLGAKVQAVDNIGCSALHLCAEHGHYRMIKLLLQYMKVV 107
Cdd:PHA02876  322 ENIRTLIMLGADVNAADRLYITPLHQASTLDrNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADI 401

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 108 EQYEtpefragdkypqrENVDEPLRLAIKNGH-YDCARLLLTNGANANA--IYFDGP-EITQVSPLDTNFLELLLEFGAD 183
Cdd:PHA02876  402 EALS-------------QKIGTALHFALCGTNpYMSVKTLIDRGANVNSknKDLSTPlHYACKKNCKLDVIEMLLDNGAD 468

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1734340008 184 PNVFDRKGLTPIMKAcrLRDKGIeaIRILLKYGADI 219
Cdd:PHA02876  469 VNAINIQNQYPLLIA--LEYHGI--VNILLHYGAEL 500
SOCS_WSB_SWIP cd03733
SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily ...
 432-463 2.50e-06

SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh), as well as, their isoforms WSB-2 and SWiP-2. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239702  Cd Length: 39  Bit Score: 43.95  E-value: 2.50e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1734340008 432 SLQHLCRIQIRDTVQTSEYKTLPIPEYLKAYL 463
Cdd:cd03733     5 SLQHLCRMALRRVMTTQQVLALPIPKKMKEFL 36
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 429-464 3.89e-06

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 43.31  E-value: 3.89e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1734340008 429 NPHSLQHLCRIQIRDTVQTSEYK---TLPIPEYLKAYLL 464
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGaidKLPLPPLLKDYLL 39
SOCS_WSB1_SWIP1 cd03746
SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily ...
 432-463 4.84e-06

SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2) and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh). The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239715  Cd Length: 40  Bit Score: 43.26  E-value: 4.84e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1734340008 432 SLQHLCRIQIRDTVQTSEYKTLPIPEYLKAYL 463
Cdd:cd03746     5 SLQHLCRMAIRRVMPTQQVKELPIPSKLLEFL 36
PHA02946 PHA02946
ankyin-like protein; Provisional
 146-333 5.95e-06

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 48.51  E-value: 5.95e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 146 LLTNGANANAIYFDGPEITQV-SPLDTN-FLELLLEFGADPNVFDRKGLTPIMKACRLRDKGIEAIRILLKYGADINKLC 223
Cdd:PHA02946   58 LLHRGYSPNETDDDGNYPLHIaSKINNNrIVAMLLTHGADPNACDKQHKTPLYYLSGTDDEVIERINLLVQYGAKINNSV 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 224 PERQdfrSALHFALLSGNHDLVKFMIANGSNVNMDEKYEKpSPIDIAVLKDDPHLLKI--VLDAGANPNAVHTYIGSCLH 301
Cdd:PHA02946  138 DEEG---CGPLLACTDPSERVFKKIMSIGFEARIVDKFGK-NHIHRHLMSDNPKASTIswMMKLGISPSKPDHDGNTPLH 213

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1734340008 302 LAsCSSLLNQYQIVELLLEhGADMNLQHQFPD 333
Cdd:PHA02946  214 IV-CSKTVKNVDIINLLLP-STDVNKQNKFGD 243
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 3-159 6.98e-06

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 48.71  E-value: 6.98e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008   3 ESHDDFESQSQLQRALAdkITNYAPIEEiryiLLRgAQVDGQVT--AGLTPLHYACYINYQAAAKLLLNLGAKVQAVDNI 80
Cdd:PLN03192  518 GEHDDPNMASNLLTVAS--TGNAALLEE----LLK-AKLDPDIGdsKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDAN 590

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008  81 GCSALHLCAEHGHYRMIKLLLQYMKVVEQYETPEF-----RAGDKYPQRE------NVDE-------PLRLAIKNGHYDC 142
Cdd:PLN03192  591 GNTALWNAISAKHHKIFRILYHFASISDPHAAGDLlctaaKRNDLTAMKEllkqglNVDSedhqgatALQVAMAEDHVDM 670

                         170
                  ....*....|....*..
gi 1734340008 143 ARLLLTNGANANAIYFD 159
Cdd:PLN03192  671 VRLLIMNGADVDKANTD 687
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 28-195 7.03e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 48.42  E-value: 7.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008  28 IEEIRYILLRGAQVDGQVTAGLTPLHYACYINYQAAAKLLLNLGAKVQAVDNIGCSALHLCAEHGHYRMIKLLLQYMKVV 107
Cdd:PHA02874  137 LESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHI 216

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 108 EQyetpefragdkypQRENVDEPLRLAIKngHYDCARLLLTNGANANAIYFDGPEITQVS---PLDTNFLELLLEFGADP 184
Cdd:PHA02874  217 MN-------------KCKNGFTPLHNAII--HNRSAIELLINNASINDQDIDGSTPLHHAinpPCDIDIIDILLYHKADI 281

                         170
                  ....*....|.
gi 1734340008 185 NVFDRKGLTPI 195
Cdd:PHA02874  282 SIKDNKGENPI 292
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 18-103 1.30e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 47.35  E-value: 1.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008  18 LADKITNYAPIEEIRYILLRGAQVDGQVTAGLTPLHYACYINYQAAAKLLLNLGAKVQAVDNIGCSALHLCAEHGHYRMI 97
Cdd:PHA03100  162 LIDKGVDINAKNRVNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIF 241


                  ....*.
gi 1734340008  98 KLLLQY 103
Cdd:PHA03100  242 KLLLNN 247
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 130-269 1.45e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 47.56  E-value: 1.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 130 PLRLAIKNGHYDCARLLLTNGANANAIYFDGPEI--TQVSPLDTNFLELLLEFGA--DPNVfdrkGLTPIMKACRLRDkg 205
Cdd:PLN03192  561 PLHIAASKGYEDCVLVLLKHACNVHIRDANGNTAlwNAISAKHHKIFRILYHFASisDPHA----AGDLLCTAAKRND-- 634

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1734340008 206 IEAIRILLKYGADINKlcpERQDFRSALHFALLSGNHDLVKFMIANGSNVNMDEKYEKPSPIDI 269
Cdd:PLN03192  635 LTAMKELLKQGLNVDS---EDHQGATALQVAMAEDHVDMVRLLIMNGADVDKANTDDDFSPTEL 695
SOCS_SOCS_like cd03717
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ...
 432-464 1.72e-05

SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.


Pssm-ID: 239687  Cd Length: 39  Bit Score: 41.81  E-value: 1.72e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1734340008 432 SLQHLCRIQIRDTVQTSEYKTLPIPEYLKAYLL 464
Cdd:cd03717     5 SLQHLCRFVIRQCTRRDLIDQLPLPRRLKDYLK 37
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 189-331 1.92e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 46.93  E-value: 1.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 189 RKGLTPIMKACRLRDkgIEAIRILLKygadinklCPeRQDF-------RSALHFALLSGNHDLVKFMIANGSN-VNM--- 257
Cdd:cd22192    15 RISESPLLLAAKEND--VQAIKKLLK--------CP-SCDLfqrgalgETALHVAALYDNLEAAVVLMEAAPElVNEpmt 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 258 DEKYEKPSPIDIAVLKDDPHLLKIVLDAGA---NPNAVHTYI---GSCL-----HLASCSSLLNQYQIVELLLEHGADMN 326
Cdd:cd22192    84 SDLYQGETALHIAVVNQNLNLVRELIARGAdvvSPRATGTFFrpgPKNLiyygeHPLSFAACVGNEEIVRLLIEHGADIR 163


                  ....*
gi 1734340008 327 LQHQF 331
Cdd:cd22192   164 AQDSL 168
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 432-464 2.44e-05

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 41.24  E-value: 2.44e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1734340008  432 SLQHLCRIQIRDtvQTSEYKTLPIPEYLKAYLL 464
Cdd:smart00969   2 SLQHLCRLAIRR--SLGGIDKLPLPPRLKDYLL 32
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 143-215 3.77e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 46.04  E-value: 3.77e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1734340008 143 ARLLLTNGANANAIYFDGPEITQVSPLD--TNFLELLLEFGADPNVFDRKGLTPIMKACRlRDKGiEAIRILLKY 215
Cdd:PTZ00322   98 ARILLTGGADPNCRDYDGRTPLHIACANghVQVVRVLLEFGADPTLLDKDGKTPLELAEE-NGFR-EVVQLLSRH 170
Ank_4 pfam13637
Ankyrin repeats (many copies);
191-249 3.96e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 41.11  E-value: 3.96e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1734340008 191 GLTPIMKACRLRDkgIEAIRILLKYGADINKLCperQDFRSALHFALLSGNHDLVKFMI 249
Cdd:pfam13637   1 ELTALHAAAASGH--LELLRLLLEKGADINAVD---GNGETALHFAASNGNVEVLKLLL 54
PHA03095 PHA03095
ankyrin-like protein; Provisional
 31-101 5.41e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 45.40  E-value: 5.41e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1734340008  31 IRYILLRGAQVDGQVTAGLTPLHYACYINYQAAAKLLLNLGAKVQAVDNIGCSALHLCAEHGHYRMIKLLL 101
Cdd:PHA03095  240 VLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAAL 310
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 429-464 7.49e-05

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 40.12  E-value: 7.49e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1734340008 429 NPHSLQHLCRIQIRDTVQTSEYKT---LPIPEYLKAYLL 464
Cdd:cd03723     2 TPRSLQHLCRCAIRKLLGSRCHKLvpqLSLPTSLKNYLL 40
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 207-304 1.55e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 43.43  E-value: 1.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 207 EAIRILLKYGADINKLCPERQD-FRSALHFALLSGNHDLVKFMIANGSNVNMDEKYEKPSPIDIAVLKDDPHLLKIVLDA 285
Cdd:PHA02884   47 DIIDAILKLGADPEAPFPLSENsKTNPLIYAIDCDNDDAAKLLIRYGADVNRYAEEAKITPLYISVLHGCLKCLEILLSY 126

                          90
                  ....*....|....*....
gi 1734340008 286 GANPNAVHTYIGSCLHLAS 304
Cdd:PHA02884  127 GADINIQTNDMVTPIELAL 145
Ank_2 pfam12796
Ankyrin repeats (3 copies);
28-78 1.59e-04

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 40.48  E-value: 1.59e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1734340008  28 IEEIRYiLLRGAQVDGQvTAGLTPLHYACYINYQAAAKLLLNLGAKVQAVD 78
Cdd:pfam12796  43 LEIVKL-LLEHADVNLK-DNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 31-103 1.77e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 44.12  E-value: 1.77e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1734340008  31 IRYILLRGAQVDGQVTAGLTPLHYACYINYQAAAKLLLNLGAKVQAVDNIGCSALHLCAEHGHYRMIKLLLQY 103
Cdd:PTZ00322   98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRH 170
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 59-155 2.66e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 43.53  E-value: 2.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008  59 NYQAAAKLLLNLGAKVQavdnIGCSALHLCAEhGHYRMIKLLLQYMKVVEQYETPEFRAGDKYPQRENVDE-PLRLAIKN 137
Cdd:TIGR00870  64 ENLELTELLLNLSCRGA----VGDTLLHAISL-EYVDAVEAILLHLLAAFRKSGPLELANDQYTSEFTPGItALHLAAHR 138

                          90
                  ....*....|....*...
gi 1734340008 138 GHYDCARLLLTNGANANA 155
Cdd:TIGR00870 139 QNYEIVKLLLERGASVPA 156
PHA02736 PHA02736
Viral ankyrin protein; Provisional
 206-287 2.84e-04

Viral ankyrin protein; Provisional


Pssm-ID: 165103 [Multi-domain]  Cd Length: 154  Bit Score: 41.40  E-value: 2.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 206 IEAIRILLKYGADINKlcPERQDFRSALHFALLSGNHDLVKFMiANGSNVNMDE-KYEKPSPIDIAVLKDDPHLLKIVLD 284
Cdd:PHA02736   71 QEKLKLLMEWGADING--KERVFGNTPLHIAVYTQNYELATWL-CNQPGVNMEIlNYAFKTPYYVACERHDAKMMNILRA 147


                  ...
gi 1734340008 285 AGA 287
Cdd:PHA02736  148 KGA 150
SOCS_ASB15 cd03731
SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a ...
 429-464 2.99e-04

SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB15 is expressed predominantly in skeletal muscle and participates in the regulation of protein turnover and muscle cell development by stimulating protein synthesis and regulating differentiation of muscle cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239701  Cd Length: 56  Bit Score: 38.66  E-value: 2.99e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1734340008 429 NPHSLQHLCRIQIRDTV------QTSEYKTLPIPEYLKAYLL 464
Cdd:cd03731     2 NPRPLKHLCRLKIRKLMglqklqQPSSMKKLPLPPALKRYIL 43
SOCS_SOCS7 cd03741
SOCS (suppressors of cytokine signaling) box of SOCS7-like proteins. Together with CIS1, the ...
 428-463 3.51e-04

SOCS (suppressors of cytokine signaling) box of SOCS7-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS7 is important in the functioning of neuronal cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239710  Cd Length: 49  Bit Score: 38.15  E-value: 3.51e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1734340008 428 KNPHSLQHLCRIQIRDTVQTSEYKTLPIPEYLKAYL 463
Cdd:cd03741     1 KNVQSLQHLCRFVIRKLVRRDHIPALPLPRRLIDYL 36
SOCS_ASB14 cd03730
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a ...
 429-464 4.54e-04

SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239700  Cd Length: 57  Bit Score: 38.29  E-value: 4.54e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1734340008 429 NPHSLQHLCRIQIRDTVQTSEYKT------LPIPEYLKAYLL 464
Cdd:cd03730     2 NPRSLKHLCRLKIRACMGRLRLRCpvfmsfLPLPNRLKAYIL 43
Ank_4 pfam13637
Ankyrin repeats (many copies);
83-147 5.76e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 37.64  E-value: 5.76e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1734340008  83 SALHLCAEHGHYRMIKLLLQYMKvveqyetpefragDKYPQRENVDEPLRLAIKNGHYDCARLLL 147
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGA-------------DINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 48-220 6.66e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 41.90  E-value: 6.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008  48 GLTPLHYACYINYQAAAKLLLNLGAKVQAVDNIGCSALHLCAEHGHYRMIKLLLQYMKVveqyetpefragdkypqrenv 127
Cdd:PHA02875  102 GMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKAC--------------------- 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 128 deplrLAIKNGhYDCArllltngananaiyfdgPEITQVSPLDTNFLELLLEFGADPNVFDRKGLTPIMkACRLRDKGIE 207
Cdd:PHA02875  161 -----LDIEDC-CGCT-----------------PLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAAL-CYAIENNKID 216

                         170
                  ....*....|...
gi 1734340008 208 AIRILLKYGADIN 220
Cdd:PHA02875  217 IVRLFIKRGADCN 229
PHA02798 PHA02798
ankyrin-like protein; Provisional
 206-366 8.36e-04

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 41.74  E-value: 8.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 206 IEAIRILLKyGADINKLCPERQDFRSALHFALLSgnHDLVKFMIANGSNVN-MDEKYEKPSPIDIAVLKDDPHLLKIVL- 283
Cdd:PHA02798   18 LSTVKLLIK-SCNPNEIVNEYSIFQKYLQRDSPS--TDIVKLFINLGANVNgLDNEYSTPLCTILSNIKDYKHMLDIVKi 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 284 --DAGANPNAVHTYIGSCLHLASCSSLLNQYQIVELLLEHGADMNLQhqfpDGSRLKSPFVeYFRSNDSIDAKVVKLFIT 361
Cdd:PHA02798   95 liENGADINKKNSDGETPLYCLLSNGYINNLEILLFMIENGADTTLL----DKDGFTMLQV-YLQSNHHIDIEIIKLLLE 169


                  ....*
gi 1734340008 362 HGAKV 366
Cdd:PHA02798  170 KGVDI 174
PHA02798 PHA02798
ankyrin-like protein; Provisional
 141-327 8.66e-04

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 41.74  E-value: 8.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 141 DCARLLLTNGANANAIYFDG--PEITQVSPLDTNFLELLL---EFGADPNVFDRKGLTPI---MKACRLRDkgIEAIRIL 212
Cdd:PHA02798   90 DIVKILIENGADINKKNSDGetPLYCLLSNGYINNLEILLfmiENGADTTLLDKDGFTMLqvyLQSNHHID--IEIIKLL 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 213 LKYGADINKLcpERQDFRSALHFALLSG----NHDLVKFMIANGSNVNMDEKYEKPSPID--IAVLKDDPHLLKIVLD-- 284
Cdd:PHA02798  168 LEKGVDINTH--NNKEKYDTLHCYFKYNidriDADILKLFVDNGFIINKENKSHKKKFMEylNSLLYDNKRFKKNILDfi 245

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1734340008 285 -AGANPNAVHTYIGSCLHlasCSSLLNQYQIVELLLEHGADMNL 327
Cdd:PHA02798  246 fSYIDINQVDELGFNPLY---YSVSHNNRKIFEYLLQLGGDINI 286
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 18-157 9.53e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 41.52  E-value: 9.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008  18 LADKITNyapIEEIRYILLRGAQVDGQVTAGLTPLHYACYINYQAAAKLLLNLGAKVQAVDNIGCSALHLCAEHGHYRMI 97
Cdd:PHA02875  108 LATILKK---LDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAIC 184

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008  98 KLLLqymkvveqyetpEFRAGDKYPQRENVDEPLRLAIKNGHYDCARLLLTNGANANAIY 157
Cdd:PHA02875  185 KMLL------------DSGANIDYFGKNGCVAALCYAIENNKIDIVRLFIKRGADCNIMF 232
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 206-374 9.61e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 41.65  E-value: 9.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 206 IEAIRILLKYGADINKLCperqDFRSALHFALLSGN--HDLVKFMIANGSNVNMDEKYEKPSpidIAVLKD---DPH--- 277
Cdd:PHA02989   16 KNALEFLLRTGFDVNEEY----RGNSILLLYLKRKDvkIKIVKLLIDNGADVNYKGYIETPL---CAVLRNreiTSNkik 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 278 -LLKIVLDAGANPNaVHTYIGS----CLHLascSSLLNQYQIVELLLEHGADM---------NLQHQFPDGSRLK----- 338
Cdd:PHA02989   89 kIVKLLLKFGADIN-LKTFNGVspivCFIY---NSNINNCDMLRFLLSKGINVndvknsrgyNLLHMYLESFSVKkdvik 164

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1734340008 339 ------------------SPFVEYFRSN-DSIDAKVVKLFITHGAKVVMRNPLHD 374
Cdd:PHA02989  165 illsfgvnlfektslyglTPMNIYLRNDiDVISIKVIKYLIKKGVNIETNNNGSE 219
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 170-248 1.16e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 41.42  E-value: 1.16e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1734340008 170 DTNFLELLLEFGADPNVFDRKGLTPIMKACRLRDKGIeaIRILLKYGADINKLcpeRQDFRSALHFALLSGNHDLVKFM 248
Cdd:PTZ00322   94 DAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQV--VRVLLEFGADPTLL---DKDGKTPLELAEENGFREVVQLL 167
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 96-366 1.54e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 41.02  E-value: 1.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008  96 MIKLLLqyMKVVEQYET--PEFRAGDKYPQRENVDE-----PLRLAIKNGHYDCARLLLTNGANANAIYFDGPEITQVSP 168
Cdd:PHA02878    1 MDKLYK--SMYTDNYETilKYIEYIDHTENYSTSASlipfiPLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIIC 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 169 LDTNFL---ELLLEFGADPNVFDRKGltpIMKACRLRDkgIEAIRILL------KYGADINKLCPERQDFrsalhfallS 239
Cdd:PHA02878   79 KEPNKLgmkEMIRSINKCSVFYTLVA---IKDAFNNRN--VEIFKIILtnryknIQTIDLVYIDKKSKDD---------I 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 240 GNHDLVKFMIANGSNVNMDEKYEKPSPIDIAVLKDDPHLLKIVLDAGANPNAVHTYIGSCLHLASCSSllnQYQIVELLL 319
Cdd:PHA02878  145 IEAEITKLLLSYGADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHY---NKPIVHILL 221

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1734340008 320 EHGADMNLQHQFPDgsrlkSPFveYFRSNDSIDAKVVKLFITHGAKV 366
Cdd:PHA02878  222 ENGASTDARDKCGN-----TPL--HISVGYCKDYDILKLLLEHGVDV 261
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 64-169 2.25e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 40.65  E-value: 2.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008  64 AKLLLNLGAKVQAVDNIGCSALHLCAEHGHYRMIKLLLqymkvveqyetpEFRAGDKYPQRENvDEPLRLAIKNGHYDCA 143
Cdd:PTZ00322   98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLL------------EFGADPTLLDKDG-KTPLELAEENGFREVV 164

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1734340008 144 RLLLTN-------GANANAIYFDG-PEITQVSPL 169
Cdd:PTZ00322  165 QLLSRHsqchfelGANAKPDSFTGkPPSLEDSPI 198
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 48-79 2.27e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 35.73  E-value: 2.27e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1734340008  48 GLTPLHYACYI-NYQAAAKLLLNLGAKVQAVDN 79
Cdd:pfam00023   2 GNTPLHLAAGRrGNLEIVKLLLSKGADVNARDK 34
SOCS_WSB2_SWIP2 cd03745
SOCS (suppressors of cytokine signaling) box of WSB2/SWiP2-like proteins. This family consists ...
 432-463 2.39e-03

SOCS (suppressors of cytokine signaling) box of WSB2/SWiP2-like proteins. This family consists of WSB-2 (SOCS-box-containing WD-40 protein) and SWiP-2 (SOCS box and WD-repeats in Protein). No functional information is available for WSB2 or SWiP-2, but limited information is available for the isoforms WSB-1 and SWiP-1. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239714  Cd Length: 39  Bit Score: 35.64  E-value: 2.39e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1734340008 432 SLQHLCRIQIRDTVQTSEYKTLPIPEYLKAYL 463
Cdd:cd03745     5 SLRHLCRKALRHFLTTYQVLALPIPKKMKEFL 36
PHA02798 PHA02798
ankyrin-like protein; Provisional
 209-363 2.56e-03

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 40.20  E-value: 2.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 209 IRILLKYGADINKLCPER-----------QDFRSALhfallsgnhDLVKFMIANGSNVNMDEKyEKPSPIDIAVLKDDPH 277
Cdd:PHA02798   54 VKLFINLGANVNGLDNEYstplctilsniKDYKHML---------DIVKILIENGADINKKNS-DGETPLYCLLSNGYIN 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 278 LLKIVL---DAGANPNAVHTYIGSCLHLASCSSLLNQYQIVELLLEHGADMNLQHQFPDGSRLKSpfveYFRSN-DSIDA 353
Cdd:PHA02798  124 NLEILLfmiENGADTTLLDKDGFTMLQVYLQSNHHIDIEIIKLLLEKGVDINTHNNKEKYDTLHC----YFKYNiDRIDA 199

                         170
                  ....*....|
gi 1734340008 354 KVVKLFITHG 363
Cdd:PHA02798  200 DILKLFVDNG 209
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 298-328 2.65e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 35.34  E-value: 2.65e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1734340008 298 SCLHLASCSSllNQYQIVELLLEHGADMNLQ 328
Cdd:pfam00023   4 TPLHLAAGRR--GNLEIVKLLLSKGADVNAR 32
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 193-326 2.67e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 39.03  E-value: 2.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734340008 193 TPIMKACRLRDKGIEAIRILLKYGADINklCPERQDFRSALHFALLSG---NHDLVKFMIANGSNVN-MDEKYEKPSPID 268
Cdd:PHA02859   53 TPIFSCLEKDKVNVEILKFLIENGADVN--FKTRDNNLSALHHYLSFNknvEPEILKILIDSGSSITeEDEDGKNLLHMY 130

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1734340008 269 IAVLKDDPHLLKIVLDAGANP--------NAVHTYIgsCLHlascssllNQYQIVELLLEHGADMN 326
Cdd:PHA02859  131 MCNFNVRINVIKLLIDSGVSFlnkdfdnnNILYSYI--LFH--------SDKKIFDFLTSLGIDIN 186
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 81-108 3.28e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.87  E-value: 3.28e-03
                           10        20
                   ....*....|....*....|....*...
gi 1734340008   81 GCSALHLCAEHGHYRMIKLLLQYMKVVE 108
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADIN 29
Ank_4 pfam13637
Ankyrin repeats (many copies);
25-68 3.29e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 35.71  E-value: 3.29e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1734340008  25 YAPIEEIRYILLRGAQVDGQVTAGLTPLHYACYINYQAAAKLLL 68
Cdd:pfam13637  11 SGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_5 pfam13857
Ankyrin repeats (many copies);
176-220 3.32e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 35.79  E-value: 3.32e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1734340008 176 LLLEFGADPNVFDRKGLTPIMKACRLRDkgIEAIRILLKYGADIN 220
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGA--LEIVRVLLAYGVDLN 43
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 228-257 3.42e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.87  E-value: 3.42e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1734340008  228 DFRSALHFALLSGNHDLVKFMIANGSNVNM 257
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
SOCS_ASB6 cd03725
SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a ...
 430-464 4.09e-03

SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB6 interacts with the adaptor protein APS and recruits elongin B/C to the insulin receptor signaling complex. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239695  Cd Length: 44  Bit Score: 35.11  E-value: 4.09e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1734340008 430 PHSLQHLCRIQIRDTVQ----TSEYKTLPIPEYLKAYLL 464
Cdd:cd03725     3 PPPLKHLCRVFIRLCLRpwpvDVKVKALPLPDRLKWYLL 41
SOCS_SOCS2 cd03736
SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the ...
 432-463 6.85e-03

SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate neuronal differentiation by controlling expression of a neurogenic transcription factor, Neurogenin-1. SOCS2 binds to GH receptors and inhibits the activation of STAT5b induced by GH. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239705  Cd Length: 41  Bit Score: 34.44  E-value: 6.85e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1734340008 432 SLQHLCRIQIRDTvqTSEYKTLPIPEYLKAYL 463
Cdd:cd03736     5 SLQHLCRITINKC--TRQIQELPLPTRLKDYL 34
SOCS_SOCS6 cd03740
SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the ...
 432-464 8.31e-03

SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239709  Cd Length: 41  Bit Score: 34.32  E-value: 8.31e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1734340008 432 SLQHLCRIQIRDTVQTSEYKTLPIPEYLKAYLL 464
Cdd:cd03740     5 SLQYLCRFVIRQYTRIDLIQKLPLPNKMKGYLL 37
Ank_4 pfam13637
Ankyrin repeats (many copies);
230-280 8.57e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 34.56  E-value: 8.57e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1734340008 230 RSALHFALLSGNHDLVKFMIANGSNVNM-DEKYEkpSPIDIAVLKDDPHLLK 280
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINAvDGNGE--TALHFAASNGNVEVLK 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH