|
Name |
Accession |
Description |
Interval |
E-value |
| SWIRM-assoc_2 |
pfam16496 |
SWIRM-associated domain at the N-terminal; Much of the higher eukaryote SWI/SNF complex ... |
4-420 |
0e+00 |
|
SWIRM-associated domain at the N-terminal; Much of the higher eukaryote SWI/SNF complex subunit SMARCC2 proteins is of low-complexity and or disordered. However, there are several short regions that are quite highly conserved. This is one of these regions. The function of the individual regions is not known.
:
Pssm-ID: 465143 Cd Length: 412 Bit Score: 759.19 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 4 RKKDGGPNVKYYEAADTVTQFDNVRLWLGKNYKKYIQAEPPTNKSLSSLVVQLLQFQEEVFGKHVSNAPLTKLPIKCFLD 83
Cdd:pfam16496 1 RKKDGGPNVKFFESPETLAQLESVRQWLGKNYKKYVQADPPTNKSLATLVVQLLQFQEDAFGKNVSKPPLTRLPMKCFLD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 84 FKAGGSLCHILAAAYKFKSDQGWRRYDFQNPSRMDRNVEMFMTIEKSLVQNNCLSRPNIFLCPEIEPKLLGKLKDIVKRH 163
Cdd:pfam16496 81 FKPGGGLCHILATAYKFKSEQGWRRFDFQNPSRMDRNVEMFMNIEKALVQNNCLTRPVIYIRPDVDKKLASKLKDIIKRH 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 164 QGTISEDKSNASHVVYPVPGNLEEEEWVRPVMKRDKQVLLHWGYYPDSYDTWIPASEIEASVEDAPTPEKPRKVHAKWIL 243
Cdd:pfam16496 161 QGTITEDEEDATHIVYPPPPDPEEEEWARPVMKRDKQVLVHWYYFPDSYDTWVPSSDVDLPVDDPPTPEKPWRVHAKWLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 244 DTDTFNEWMNEEDYEVSDDKSPVSRRKKISAKtltDEVNSPDSDRRDKKGGNYKKRKRSPSPSPTPEAKKKNAKKGPstP 323
Cdd:pfam16496 241 DLDQYNEWMNEEDYEVDENGKKKSHRQRISVE---DEMSSPDPDRKDKKSSPGKKRKRSPSPPPTPVGKKKSGRKGS--P 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 324 YTKSKRGHREEEQEDLTKDMDEPSPVPNVEEVTLPKTVNTKKDSESAPVKGGTMTDLDEQDDESMETTGKDEDENSTGNK 403
Cdd:pfam16496 316 ARRKKRRREEEEEEDLTKDMEDPTPVPNIEEVNLPKNVNSKKDSENQPVKGGTMTDLDEQEDDKVESGGKEDEEGGKTSK 395
|
410
....*....|....*..
gi 1732634166 404 GEQTKNPDLHEDNVTEQ 420
Cdd:pfam16496 396 GEGSRLSDEHEDNVTEQ 412
|
|
| RSC8 super family |
cl34960 |
RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / ... |
379-739 |
1.49e-85 |
|
RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription];
The actual alignment was detected with superfamily member COG5259:
Pssm-ID: 227584 [Multi-domain] Cd Length: 531 Bit Score: 288.71 E-value: 1.49e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 379 DLDEQDDESMETTGkdeDENSTGNKGEQTKNPDLHEDNVTEQTHHIIIPSYAAWFDYNSVHAIERRALPEFFNGKNKSKT 458
Cdd:COG5259 10 DSGEERNEQSAEIM---DHSKSANEKKTTILRVEAETFLMEQTHPIIIPSYAEWFDGSKIHEIEKRSNPEFFNGRSPSKT 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 459 PEIYLAYRNFMIDTYRLNPQEYLTSTACRRNLAGDVCAIMRVHAFLEQWGLINYQVDAESRPTPMGPPPTSHFHVLADTP 538
Cdd:COG5259 87 PEVYKDYRNFMINSYRLNPNEYLTVTACRRNVAGDVAAIVRVHRFLEKWGLINYQVDPGTRPSTIGPPLTSHFQDLHDTP 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 539 SGLVPLQPKPPQGRQVD-ADTKAGRKGKE------LDDLVpETAKGKPELQSSASQQMLNFPEKGKEKPADMQNFGLRTD 611
Cdd:COG5259 167 RGLSPFLPWGPINQRVLgAKEIEYETHKEenyspsLKSPK-KESQGKVDELKDHSEKHPSSCSCCGNKSFNTRYHNLRAE 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 612 MYT------KKNV-PSKS------KAAASATRE---WTEQETLLLLEALEMYKDDWNKVSEHVGSRTQDECILHFLRLPI 675
Cdd:COG5259 246 KYNscsecyDQGRfPSEFtssdfkPVTISLLIRdknWSRQELLLLLEGIEMYGDDWDKVARHVGTKTKEQCILHFLQLPI 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1732634166 676 EDPYLEDSEASlGPLAYQPIPFSQSGNPVMSTVAFLASVVDPRVAS----AAAKSALEEFSKMKEEVP 739
Cdd:COG5259 326 EDNYLSKGDGK-GDNSKGRLPFDGSENPVLSTISFLAGIVNPRVQSekqrAIIKSGKISHINRESQEH 392
|
|
| SWIRM-assoc_3 |
pfam16498 |
SWIRM-associated domain at the C-terminal; Much of the higher eukaryote SWI/SNF complex ... |
715-781 |
1.50e-34 |
|
SWIRM-associated domain at the C-terminal; Much of the higher eukaryote SWI/SNF complex subunit SMARCC2 proteins is of low-complexity and or disordered. However, there are several short regions that are quite highly conserved. This is one of these regions. The function of the individual regions is not known.
:
Pssm-ID: 465145 [Multi-domain] Cd Length: 67 Bit Score: 126.31 E-value: 1.50e-34
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1732634166 715 VDPRVASAAAKSALEEFSKMKEEVPTALVEAHVRKVEEAAKVTGKADPAFGLESSGIAGTASDEPER 781
Cdd:pfam16498 1 VDPRVAAAAAKAAMEEFSKIKEEVPPALVEAHVKNVEEAAKKGGKVDPAFGLEKSGIAGTDPEEPEK 67
|
|
| SWIRM-assoc_1 |
pfam16495 |
SWIRM-associated region 1; Much of the higher eukaryote SWI/SNF complex subunit SMARCC2 ... |
911-977 |
1.72e-32 |
|
SWIRM-associated region 1; Much of the higher eukaryote SWI/SNF complex subunit SMARCC2 proteins is of low-complexity and or disordered. However, there are several short regions that are quite highly conserved. This is one of these regions. The function of the individual regions is not known.
:
Pssm-ID: 465142 [Multi-domain] Cd Length: 84 Bit Score: 121.09 E-value: 1.72e-32
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1732634166 911 EERKIKSLVALLVETQMKKLEIKLRHFEELETIMDREREALEYQRQQLLADRQAFHMEQLKYAEMRA 977
Cdd:pfam16495 18 EEREIQRLVALLVETQLKKLELKLKQFEELEKLLERERRQLERQRQQLFLERLAFKKQRLEVAEKLA 84
|
|
| PHA03247 super family |
cl33720 |
large tegument protein UL36; Provisional |
994-1233 |
4.24e-05 |
|
large tegument protein UL36; Provisional
The actual alignment was detected with superfamily member PHA03247:
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 48.40 E-value: 4.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 994 PTLPPGSQPIPPTGAAGPPTVHGLAVPPAavasappgSGAPPGSLGPSEqiGQAGTTAGPQQPQQAGAPQPGAVPPGVPP 1073
Cdd:PHA03247 2601 PVDDRGDPRGPAPPSPLPPDTHAPDPPPP--------SPSPAANEPDPH--PPPTVPPPERPRDDPAPGRVSRPRRARRL 2670
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 1074 PGPHGPSPFPNQPTPPSMMP--GAVPGSGHPGVAGNAPLGLPFGMPPPPPAAPSVIPFGSLADSISINLPPPPNLHGhhh 1151
Cdd:PHA03247 2671 GRAAQASSPPQRPRRRAARPtvGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAG--- 2747
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 1152 hlPFAPGTIPPPNLPVSMANPLHPNLPA--------TTTMPSSLPLGPGLGSA-----AAQSPAIVAAVQGNLLPSASP- 1217
Cdd:PHA03247 2748 --PATPGGPARPARPPTTAGPPAPAPPAapaagpprRLTRPAVASLSESRESLpspwdPADPPAAVLAPAAALPPAASPa 2825
|
250
....*....|....*...
gi 1732634166 1218 --LPDPGTPLPPDPTAPS 1233
Cdd:PHA03247 2826 gpLPPPTSAQPTAPPPPP 2843
|
|
| PTZ00121 super family |
cl31754 |
MAEBL; Provisional |
721-957 |
1.37e-04 |
|
MAEBL; Provisional
The actual alignment was detected with superfamily member PTZ00121:
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 46.67 E-value: 1.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 721 SAAAKSALEEFSKMKEEVPTAlvEAHVRKVEEAAK---VTGKADPAFGLESsgiAGTASDEPERIEESG--TEEARPEGQ 795
Cdd:PTZ00121 1413 AAAAKKKADEAKKKAEEKKKA--DEAKKKAEEAKKadeAKKKAEEAKKAEE---AKKKAEEAKKADEAKkkAEEAKKADE 1487
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 796 A----------ADEKKEPKEPREGGGAVEEEAKEEISEVPKKDEEKGKEGDSEKESEKSDGDPIVDPE---KDKEPTEGQ 862
Cdd:PTZ00121 1488 AkkkaeeakkkADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEelkKAEEKKKAE 1567
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 863 EEVLKEVAEPEGERKTKVERDIGEGNLSTAAAAALAAAAVKAKHLAAVEERKIKSlvallveTQMKKLEIKLRHFEELET 942
Cdd:PTZ00121 1568 EAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKA-------EELKKAEEEKKKVEQLKK 1640
|
250
....*....|....*
gi 1732634166 943 IMDREREALEYQRQQ 957
Cdd:PTZ00121 1641 KEAEEKKKAEELKKA 1655
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| SWIRM-assoc_2 |
pfam16496 |
SWIRM-associated domain at the N-terminal; Much of the higher eukaryote SWI/SNF complex ... |
4-420 |
0e+00 |
|
SWIRM-associated domain at the N-terminal; Much of the higher eukaryote SWI/SNF complex subunit SMARCC2 proteins is of low-complexity and or disordered. However, there are several short regions that are quite highly conserved. This is one of these regions. The function of the individual regions is not known.
Pssm-ID: 465143 Cd Length: 412 Bit Score: 759.19 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 4 RKKDGGPNVKYYEAADTVTQFDNVRLWLGKNYKKYIQAEPPTNKSLSSLVVQLLQFQEEVFGKHVSNAPLTKLPIKCFLD 83
Cdd:pfam16496 1 RKKDGGPNVKFFESPETLAQLESVRQWLGKNYKKYVQADPPTNKSLATLVVQLLQFQEDAFGKNVSKPPLTRLPMKCFLD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 84 FKAGGSLCHILAAAYKFKSDQGWRRYDFQNPSRMDRNVEMFMTIEKSLVQNNCLSRPNIFLCPEIEPKLLGKLKDIVKRH 163
Cdd:pfam16496 81 FKPGGGLCHILATAYKFKSEQGWRRFDFQNPSRMDRNVEMFMNIEKALVQNNCLTRPVIYIRPDVDKKLASKLKDIIKRH 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 164 QGTISEDKSNASHVVYPVPGNLEEEEWVRPVMKRDKQVLLHWGYYPDSYDTWIPASEIEASVEDAPTPEKPRKVHAKWIL 243
Cdd:pfam16496 161 QGTITEDEEDATHIVYPPPPDPEEEEWARPVMKRDKQVLVHWYYFPDSYDTWVPSSDVDLPVDDPPTPEKPWRVHAKWLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 244 DTDTFNEWMNEEDYEVSDDKSPVSRRKKISAKtltDEVNSPDSDRRDKKGGNYKKRKRSPSPSPTPEAKKKNAKKGPstP 323
Cdd:pfam16496 241 DLDQYNEWMNEEDYEVDENGKKKSHRQRISVE---DEMSSPDPDRKDKKSSPGKKRKRSPSPPPTPVGKKKSGRKGS--P 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 324 YTKSKRGHREEEQEDLTKDMDEPSPVPNVEEVTLPKTVNTKKDSESAPVKGGTMTDLDEQDDESMETTGKDEDENSTGNK 403
Cdd:pfam16496 316 ARRKKRRREEEEEEDLTKDMEDPTPVPNIEEVNLPKNVNSKKDSENQPVKGGTMTDLDEQEDDKVESGGKEDEEGGKTSK 395
|
410
....*....|....*..
gi 1732634166 404 GEQTKNPDLHEDNVTEQ 420
Cdd:pfam16496 396 GEGSRLSDEHEDNVTEQ 412
|
|
| RSC8 |
COG5259 |
RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / ... |
379-739 |
1.49e-85 |
|
RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription];
Pssm-ID: 227584 [Multi-domain] Cd Length: 531 Bit Score: 288.71 E-value: 1.49e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 379 DLDEQDDESMETTGkdeDENSTGNKGEQTKNPDLHEDNVTEQTHHIIIPSYAAWFDYNSVHAIERRALPEFFNGKNKSKT 458
Cdd:COG5259 10 DSGEERNEQSAEIM---DHSKSANEKKTTILRVEAETFLMEQTHPIIIPSYAEWFDGSKIHEIEKRSNPEFFNGRSPSKT 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 459 PEIYLAYRNFMIDTYRLNPQEYLTSTACRRNLAGDVCAIMRVHAFLEQWGLINYQVDAESRPTPMGPPPTSHFHVLADTP 538
Cdd:COG5259 87 PEVYKDYRNFMINSYRLNPNEYLTVTACRRNVAGDVAAIVRVHRFLEKWGLINYQVDPGTRPSTIGPPLTSHFQDLHDTP 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 539 SGLVPLQPKPPQGRQVD-ADTKAGRKGKE------LDDLVpETAKGKPELQSSASQQMLNFPEKGKEKPADMQNFGLRTD 611
Cdd:COG5259 167 RGLSPFLPWGPINQRVLgAKEIEYETHKEenyspsLKSPK-KESQGKVDELKDHSEKHPSSCSCCGNKSFNTRYHNLRAE 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 612 MYT------KKNV-PSKS------KAAASATRE---WTEQETLLLLEALEMYKDDWNKVSEHVGSRTQDECILHFLRLPI 675
Cdd:COG5259 246 KYNscsecyDQGRfPSEFtssdfkPVTISLLIRdknWSRQELLLLLEGIEMYGDDWDKVARHVGTKTKEQCILHFLQLPI 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1732634166 676 EDPYLEDSEASlGPLAYQPIPFSQSGNPVMSTVAFLASVVDPRVAS----AAAKSALEEFSKMKEEVP 739
Cdd:COG5259 326 EDNYLSKGDGK-GDNSKGRLPFDGSENPVLSTISFLAGIVNPRVQSekqrAIIKSGKISHINRESQEH 392
|
|
| SWIRM |
pfam04433 |
SWIRM domain; This SWIRM domain is a small alpha-helical domain of about 85 amino acid ... |
433-512 |
7.99e-37 |
|
SWIRM domain; This SWIRM domain is a small alpha-helical domain of about 85 amino acid residues found in chromosomal proteins. It contains a helix-turn helix motif and binds to DNA.
Pssm-ID: 461307 [Multi-domain] Cd Length: 78 Bit Score: 133.07 E-value: 7.99e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 433 FDYNSVHAIERRALPEFFNGKnkSKTPEIYLAYRNFMIDTYRLNPQEYLTSTACRRNLAGDVCAIMRVHAFLEQWGLINY 512
Cdd:pfam04433 1 SDPDKLHPIEKRLLPEFFNGK--SKTPEVYLEIRNFILNLWRENPKEYLTKTDARRALKGDVNLISRIHEFLERWGLINF 78
|
|
| SWIRM-assoc_3 |
pfam16498 |
SWIRM-associated domain at the C-terminal; Much of the higher eukaryote SWI/SNF complex ... |
715-781 |
1.50e-34 |
|
SWIRM-associated domain at the C-terminal; Much of the higher eukaryote SWI/SNF complex subunit SMARCC2 proteins is of low-complexity and or disordered. However, there are several short regions that are quite highly conserved. This is one of these regions. The function of the individual regions is not known.
Pssm-ID: 465145 [Multi-domain] Cd Length: 67 Bit Score: 126.31 E-value: 1.50e-34
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1732634166 715 VDPRVASAAAKSALEEFSKMKEEVPTALVEAHVRKVEEAAKVTGKADPAFGLESSGIAGTASDEPER 781
Cdd:pfam16498 1 VDPRVAAAAAKAAMEEFSKIKEEVPPALVEAHVKNVEEAAKKGGKVDPAFGLEKSGIAGTDPEEPEK 67
|
|
| SWIRM-assoc_1 |
pfam16495 |
SWIRM-associated region 1; Much of the higher eukaryote SWI/SNF complex subunit SMARCC2 ... |
911-977 |
1.72e-32 |
|
SWIRM-associated region 1; Much of the higher eukaryote SWI/SNF complex subunit SMARCC2 proteins is of low-complexity and or disordered. However, there are several short regions that are quite highly conserved. This is one of these regions. The function of the individual regions is not known.
Pssm-ID: 465142 [Multi-domain] Cd Length: 84 Bit Score: 121.09 E-value: 1.72e-32
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1732634166 911 EERKIKSLVALLVETQMKKLEIKLRHFEELETIMDREREALEYQRQQLLADRQAFHMEQLKYAEMRA 977
Cdd:pfam16495 18 EEREIQRLVALLVETQLKKLELKLKQFEELEKLLERERRQLERQRQQLFLERLAFKKQRLEVAEKLA 84
|
|
| CHROMO |
smart00298 |
Chromatin organization modifier domain; |
187-222 |
1.20e-05 |
|
Chromatin organization modifier domain;
Pssm-ID: 214605 [Multi-domain] Cd Length: 55 Bit Score: 43.74 E-value: 1.20e-05
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 1732634166 187 EEEWVRPVMKR-----DKQVLLHWGYYPDSYDTWIPASEIE 222
Cdd:smart00298 1 EYEVEKILDHRwkkkgELEYLVKWKGYSYSEDTWEPEENLL 41
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
994-1233 |
4.24e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 48.40 E-value: 4.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 994 PTLPPGSQPIPPTGAAGPPTVHGLAVPPAavasappgSGAPPGSLGPSEqiGQAGTTAGPQQPQQAGAPQPGAVPPGVPP 1073
Cdd:PHA03247 2601 PVDDRGDPRGPAPPSPLPPDTHAPDPPPP--------SPSPAANEPDPH--PPPTVPPPERPRDDPAPGRVSRPRRARRL 2670
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 1074 PGPHGPSPFPNQPTPPSMMP--GAVPGSGHPGVAGNAPLGLPFGMPPPPPAAPSVIPFGSLADSISINLPPPPNLHGhhh 1151
Cdd:PHA03247 2671 GRAAQASSPPQRPRRRAARPtvGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAG--- 2747
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 1152 hlPFAPGTIPPPNLPVSMANPLHPNLPA--------TTTMPSSLPLGPGLGSA-----AAQSPAIVAAVQGNLLPSASP- 1217
Cdd:PHA03247 2748 --PATPGGPARPARPPTTAGPPAPAPPAapaagpprRLTRPAVASLSESRESLpspwdPADPPAAVLAPAAALPPAASPa 2825
|
250
....*....|....*...
gi 1732634166 1218 --LPDPGTPLPPDPTAPS 1233
Cdd:PHA03247 2826 gpLPPPTSAQPTAPPPPP 2843
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
721-957 |
1.37e-04 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 46.67 E-value: 1.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 721 SAAAKSALEEFSKMKEEVPTAlvEAHVRKVEEAAK---VTGKADPAFGLESsgiAGTASDEPERIEESG--TEEARPEGQ 795
Cdd:PTZ00121 1413 AAAAKKKADEAKKKAEEKKKA--DEAKKKAEEAKKadeAKKKAEEAKKAEE---AKKKAEEAKKADEAKkkAEEAKKADE 1487
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 796 A----------ADEKKEPKEPREGGGAVEEEAKEEISEVPKKDEEKGKEGDSEKESEKSDGDPIVDPE---KDKEPTEGQ 862
Cdd:PTZ00121 1488 AkkkaeeakkkADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEelkKAEEKKKAE 1567
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 863 EEVLKEVAEPEGERKTKVERDIGEGNLSTAAAAALAAAAVKAKHLAAVEERKIKSlvallveTQMKKLEIKLRHFEELET 942
Cdd:PTZ00121 1568 EAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKA-------EELKKAEEEKKKVEQLKK 1640
|
250
....*....|....*
gi 1732634166 943 IMDREREALEYQRQQ 957
Cdd:PTZ00121 1641 KEAEEKKKAEELKKA 1655
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
993-1232 |
4.28e-04 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 44.76 E-value: 4.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 993 PPTLPPGSQPIPPTGAAGPPTVHGLAVPPAAVASAPPGSGAPPGSLGPSEQIGQAGT-TAGPQQPQQAGAPQPGAVPPGV 1071
Cdd:pfam03154 171 PPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPhTLIQQTPTLHPQRLPSPHPPLQ 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 1072 PPPGPHGPSPFPNQPTPPSMMPGAVPGSGHPGVAGNAPLGLPFGMPppppaapsviPFGSLADSISINLPPPPNLHGHHH 1151
Cdd:pfam03154 251 PMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQ----------PFPLTPQSSQSQVPPGPSPAAPGQ 320
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 1152 H-----------------------LPFAPGTI----PPPNLPV-------SMANPLHPNLPATTTMPSSLPLGPGLGSaa 1197
Cdd:pfam03154 321 SqqrihtppsqsqlqsqqppreqpLPPAPLSMphikPPPTTPIpqlpnpqSHKHPPHLSGPSPFQMNSNLPPPPALKP-- 398
|
250 260 270
....*....|....*....|....*....|....*....
gi 1732634166 1198 aqspaiVAAVQGNLLPSASPLP----DPGTPLPPDPTAP 1232
Cdd:pfam03154 399 ------LSSLSTHHPPSAHPPPlqlmPQSQQLPPPPAQP 431
|
|
| 2A1904 |
TIGR00927 |
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ... |
763-963 |
1.02e-03 |
|
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273344 [Multi-domain] Cd Length: 1096 Bit Score: 43.45 E-value: 1.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 763 AFGLESSGIAGTASDEPERIEESGTEEARPEGQAADEKKEPKEPREGGGAVEEEAKEEISEVPKKDEEKGkEGDSEKESE 842
Cdd:TIGR00927 626 ALGDLSKGDVAEAEHTGERTGEEGERPTEAEGENGEESGGEAEQEGETETKGENESEGEIPAERKGEQEG-EGEIEAKEA 704
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 843 KSDGDPIV---------DPEKDKEPTEGQEEVLKEVAEPEGE--------RKTKVERDIGEGNLSTAAAAALAAAAVKAK 905
Cdd:TIGR00927 705 DHKGETEAeevehegetEAEGTEDEGEIETGEEGEEVEDEGEgeaegkheVETEGDRKETEHEGETEAEGKEDEDEGEIQ 784
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1732634166 906 HLAAVEERKIKSLVALLVETQMKKLEIKLRHFEELETIMDREREALEYQRQQLLADRQ 963
Cdd:TIGR00927 785 AGEDGEMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDETGEQELNAENQ 842
|
|
| Caldesmon |
pfam02029 |
Caldesmon; |
748-978 |
8.31e-03 |
|
Caldesmon;
Pssm-ID: 460421 [Multi-domain] Cd Length: 495 Bit Score: 40.24 E-value: 8.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 748 RKVEEAAKVTGKADPAFGLESSGIAgtasDEPERIEESGTEEARPEGQAADEKKEPKEpregggaveeeakEEISEVPKK 827
Cdd:pfam02029 77 KRLQEALERQKEFDPTIADEKESVA----ERKENNEEEENSSWEKEEKRDSRLGRYKE-------------EETEIREKE 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 828 D------------EEKG-KEGDSEKESEKSDGDPIVDPEKDKEPTEGQEEVLKEVAEPEGERKTKVERDIGEGNLSTAAA 894
Cdd:pfam02029 140 YqenkwstevrqaEEEGeEEEDKSEEAEEVPTENFAKEEVKDEKIKKEKKVKYESKVFLDQKRGHPEVKSQNGEEEVTKL 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 895 AALAAAAVKAKHLAAVEERKIKSlvalLVETQMKKLEIKLRH---------------------FEELETIMDREREALEY 953
Cdd:pfam02029 220 KVTTKRRQGGLSQSQEREEEAEV----FLEAEQKLEELRRRRqekeseefeklrqkqqeaeleLEELKKKREERRKLLEE 295
|
250 260
....*....|....*....|....*
gi 1732634166 954 QRQQllaDRQAFHMEQLKYAEMRAR 978
Cdd:pfam02029 296 EEQR---RKQEEAERKLREEEEKRR 317
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| SWIRM-assoc_2 |
pfam16496 |
SWIRM-associated domain at the N-terminal; Much of the higher eukaryote SWI/SNF complex ... |
4-420 |
0e+00 |
|
SWIRM-associated domain at the N-terminal; Much of the higher eukaryote SWI/SNF complex subunit SMARCC2 proteins is of low-complexity and or disordered. However, there are several short regions that are quite highly conserved. This is one of these regions. The function of the individual regions is not known.
Pssm-ID: 465143 Cd Length: 412 Bit Score: 759.19 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 4 RKKDGGPNVKYYEAADTVTQFDNVRLWLGKNYKKYIQAEPPTNKSLSSLVVQLLQFQEEVFGKHVSNAPLTKLPIKCFLD 83
Cdd:pfam16496 1 RKKDGGPNVKFFESPETLAQLESVRQWLGKNYKKYVQADPPTNKSLATLVVQLLQFQEDAFGKNVSKPPLTRLPMKCFLD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 84 FKAGGSLCHILAAAYKFKSDQGWRRYDFQNPSRMDRNVEMFMTIEKSLVQNNCLSRPNIFLCPEIEPKLLGKLKDIVKRH 163
Cdd:pfam16496 81 FKPGGGLCHILATAYKFKSEQGWRRFDFQNPSRMDRNVEMFMNIEKALVQNNCLTRPVIYIRPDVDKKLASKLKDIIKRH 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 164 QGTISEDKSNASHVVYPVPGNLEEEEWVRPVMKRDKQVLLHWGYYPDSYDTWIPASEIEASVEDAPTPEKPRKVHAKWIL 243
Cdd:pfam16496 161 QGTITEDEEDATHIVYPPPPDPEEEEWARPVMKRDKQVLVHWYYFPDSYDTWVPSSDVDLPVDDPPTPEKPWRVHAKWLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 244 DTDTFNEWMNEEDYEVSDDKSPVSRRKKISAKtltDEVNSPDSDRRDKKGGNYKKRKRSPSPSPTPEAKKKNAKKGPstP 323
Cdd:pfam16496 241 DLDQYNEWMNEEDYEVDENGKKKSHRQRISVE---DEMSSPDPDRKDKKSSPGKKRKRSPSPPPTPVGKKKSGRKGS--P 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 324 YTKSKRGHREEEQEDLTKDMDEPSPVPNVEEVTLPKTVNTKKDSESAPVKGGTMTDLDEQDDESMETTGKDEDENSTGNK 403
Cdd:pfam16496 316 ARRKKRRREEEEEEDLTKDMEDPTPVPNIEEVNLPKNVNSKKDSENQPVKGGTMTDLDEQEDDKVESGGKEDEEGGKTSK 395
|
410
....*....|....*..
gi 1732634166 404 GEQTKNPDLHEDNVTEQ 420
Cdd:pfam16496 396 GEGSRLSDEHEDNVTEQ 412
|
|
| RSC8 |
COG5259 |
RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / ... |
379-739 |
1.49e-85 |
|
RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription];
Pssm-ID: 227584 [Multi-domain] Cd Length: 531 Bit Score: 288.71 E-value: 1.49e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 379 DLDEQDDESMETTGkdeDENSTGNKGEQTKNPDLHEDNVTEQTHHIIIPSYAAWFDYNSVHAIERRALPEFFNGKNKSKT 458
Cdd:COG5259 10 DSGEERNEQSAEIM---DHSKSANEKKTTILRVEAETFLMEQTHPIIIPSYAEWFDGSKIHEIEKRSNPEFFNGRSPSKT 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 459 PEIYLAYRNFMIDTYRLNPQEYLTSTACRRNLAGDVCAIMRVHAFLEQWGLINYQVDAESRPTPMGPPPTSHFHVLADTP 538
Cdd:COG5259 87 PEVYKDYRNFMINSYRLNPNEYLTVTACRRNVAGDVAAIVRVHRFLEKWGLINYQVDPGTRPSTIGPPLTSHFQDLHDTP 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 539 SGLVPLQPKPPQGRQVD-ADTKAGRKGKE------LDDLVpETAKGKPELQSSASQQMLNFPEKGKEKPADMQNFGLRTD 611
Cdd:COG5259 167 RGLSPFLPWGPINQRVLgAKEIEYETHKEenyspsLKSPK-KESQGKVDELKDHSEKHPSSCSCCGNKSFNTRYHNLRAE 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 612 MYT------KKNV-PSKS------KAAASATRE---WTEQETLLLLEALEMYKDDWNKVSEHVGSRTQDECILHFLRLPI 675
Cdd:COG5259 246 KYNscsecyDQGRfPSEFtssdfkPVTISLLIRdknWSRQELLLLLEGIEMYGDDWDKVARHVGTKTKEQCILHFLQLPI 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1732634166 676 EDPYLEDSEASlGPLAYQPIPFSQSGNPVMSTVAFLASVVDPRVAS----AAAKSALEEFSKMKEEVP 739
Cdd:COG5259 326 EDNYLSKGDGK-GDNSKGRLPFDGSENPVLSTISFLAGIVNPRVQSekqrAIIKSGKISHINRESQEH 392
|
|
| SWIRM |
pfam04433 |
SWIRM domain; This SWIRM domain is a small alpha-helical domain of about 85 amino acid ... |
433-512 |
7.99e-37 |
|
SWIRM domain; This SWIRM domain is a small alpha-helical domain of about 85 amino acid residues found in chromosomal proteins. It contains a helix-turn helix motif and binds to DNA.
Pssm-ID: 461307 [Multi-domain] Cd Length: 78 Bit Score: 133.07 E-value: 7.99e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 433 FDYNSVHAIERRALPEFFNGKnkSKTPEIYLAYRNFMIDTYRLNPQEYLTSTACRRNLAGDVCAIMRVHAFLEQWGLINY 512
Cdd:pfam04433 1 SDPDKLHPIEKRLLPEFFNGK--SKTPEVYLEIRNFILNLWRENPKEYLTKTDARRALKGDVNLISRIHEFLERWGLINF 78
|
|
| SWIRM-assoc_3 |
pfam16498 |
SWIRM-associated domain at the C-terminal; Much of the higher eukaryote SWI/SNF complex ... |
715-781 |
1.50e-34 |
|
SWIRM-associated domain at the C-terminal; Much of the higher eukaryote SWI/SNF complex subunit SMARCC2 proteins is of low-complexity and or disordered. However, there are several short regions that are quite highly conserved. This is one of these regions. The function of the individual regions is not known.
Pssm-ID: 465145 [Multi-domain] Cd Length: 67 Bit Score: 126.31 E-value: 1.50e-34
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1732634166 715 VDPRVASAAAKSALEEFSKMKEEVPTALVEAHVRKVEEAAKVTGKADPAFGLESSGIAGTASDEPER 781
Cdd:pfam16498 1 VDPRVAAAAAKAAMEEFSKIKEEVPPALVEAHVKNVEEAAKKGGKVDPAFGLEKSGIAGTDPEEPEK 67
|
|
| SWIRM-assoc_1 |
pfam16495 |
SWIRM-associated region 1; Much of the higher eukaryote SWI/SNF complex subunit SMARCC2 ... |
911-977 |
1.72e-32 |
|
SWIRM-associated region 1; Much of the higher eukaryote SWI/SNF complex subunit SMARCC2 proteins is of low-complexity and or disordered. However, there are several short regions that are quite highly conserved. This is one of these regions. The function of the individual regions is not known.
Pssm-ID: 465142 [Multi-domain] Cd Length: 84 Bit Score: 121.09 E-value: 1.72e-32
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1732634166 911 EERKIKSLVALLVETQMKKLEIKLRHFEELETIMDREREALEYQRQQLLADRQAFHMEQLKYAEMRA 977
Cdd:pfam16495 18 EEREIQRLVALLVETQLKKLELKLKQFEELEKLLERERRQLERQRQQLFLERLAFKKQRLEVAEKLA 84
|
|
| CHROMO |
smart00298 |
Chromatin organization modifier domain; |
187-222 |
1.20e-05 |
|
Chromatin organization modifier domain;
Pssm-ID: 214605 [Multi-domain] Cd Length: 55 Bit Score: 43.74 E-value: 1.20e-05
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 1732634166 187 EEEWVRPVMKR-----DKQVLLHWGYYPDSYDTWIPASEIE 222
Cdd:smart00298 1 EYEVEKILDHRwkkkgELEYLVKWKGYSYSEDTWEPEENLL 41
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
994-1233 |
4.24e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 48.40 E-value: 4.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 994 PTLPPGSQPIPPTGAAGPPTVHGLAVPPAavasappgSGAPPGSLGPSEqiGQAGTTAGPQQPQQAGAPQPGAVPPGVPP 1073
Cdd:PHA03247 2601 PVDDRGDPRGPAPPSPLPPDTHAPDPPPP--------SPSPAANEPDPH--PPPTVPPPERPRDDPAPGRVSRPRRARRL 2670
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 1074 PGPHGPSPFPNQPTPPSMMP--GAVPGSGHPGVAGNAPLGLPFGMPPPPPAAPSVIPFGSLADSISINLPPPPNLHGhhh 1151
Cdd:PHA03247 2671 GRAAQASSPPQRPRRRAARPtvGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAG--- 2747
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 1152 hlPFAPGTIPPPNLPVSMANPLHPNLPA--------TTTMPSSLPLGPGLGSA-----AAQSPAIVAAVQGNLLPSASP- 1217
Cdd:PHA03247 2748 --PATPGGPARPARPPTTAGPPAPAPPAapaagpprRLTRPAVASLSESRESLpspwdPADPPAAVLAPAAALPPAASPa 2825
|
250
....*....|....*...
gi 1732634166 1218 --LPDPGTPLPPDPTAPS 1233
Cdd:PHA03247 2826 gpLPPPTSAQPTAPPPPP 2843
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
721-957 |
1.37e-04 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 46.67 E-value: 1.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 721 SAAAKSALEEFSKMKEEVPTAlvEAHVRKVEEAAK---VTGKADPAFGLESsgiAGTASDEPERIEESG--TEEARPEGQ 795
Cdd:PTZ00121 1413 AAAAKKKADEAKKKAEEKKKA--DEAKKKAEEAKKadeAKKKAEEAKKAEE---AKKKAEEAKKADEAKkkAEEAKKADE 1487
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 796 A----------ADEKKEPKEPREGGGAVEEEAKEEISEVPKKDEEKGKEGDSEKESEKSDGDPIVDPE---KDKEPTEGQ 862
Cdd:PTZ00121 1488 AkkkaeeakkkADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEelkKAEEKKKAE 1567
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 863 EEVLKEVAEPEGERKTKVERDIGEGNLSTAAAAALAAAAVKAKHLAAVEERKIKSlvallveTQMKKLEIKLRHFEELET 942
Cdd:PTZ00121 1568 EAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKA-------EELKKAEEEKKKVEQLKK 1640
|
250
....*....|....*
gi 1732634166 943 IMDREREALEYQRQQ 957
Cdd:PTZ00121 1641 KEAEEKKKAEELKKA 1655
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
993-1232 |
4.28e-04 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 44.76 E-value: 4.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 993 PPTLPPGSQPIPPTGAAGPPTVHGLAVPPAAVASAPPGSGAPPGSLGPSEQIGQAGT-TAGPQQPQQAGAPQPGAVPPGV 1071
Cdd:pfam03154 171 PPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPhTLIQQTPTLHPQRLPSPHPPLQ 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 1072 PPPGPHGPSPFPNQPTPPSMMPGAVPGSGHPGVAGNAPLGLPFGMPppppaapsviPFGSLADSISINLPPPPNLHGHHH 1151
Cdd:pfam03154 251 PMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQ----------PFPLTPQSSQSQVPPGPSPAAPGQ 320
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 1152 H-----------------------LPFAPGTI----PPPNLPV-------SMANPLHPNLPATTTMPSSLPLGPGLGSaa 1197
Cdd:pfam03154 321 SqqrihtppsqsqlqsqqppreqpLPPAPLSMphikPPPTTPIpqlpnpqSHKHPPHLSGPSPFQMNSNLPPPPALKP-- 398
|
250 260 270
....*....|....*....|....*....|....*....
gi 1732634166 1198 aqspaiVAAVQGNLLPSASPLP----DPGTPLPPDPTAP 1232
Cdd:pfam03154 399 ------LSSLSTHHPPSAHPPPlqlmPQSQQLPPPPAQP 431
|
|
| Myb_DNA-binding |
pfam00249 |
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ... |
646-673 |
5.90e-04 |
|
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.
Pssm-ID: 459731 [Multi-domain] Cd Length: 46 Bit Score: 38.64 E-value: 5.90e-04
10 20
....*....|....*....|....*...
gi 1732634166 646 MYKDDWNKVSEHVGSRTQDECILHFLRL 673
Cdd:pfam00249 18 KLGNRWKKIAKLLPGRTDNQCKNRWQNY 45
|
|
| 2A1904 |
TIGR00927 |
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ... |
763-963 |
1.02e-03 |
|
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273344 [Multi-domain] Cd Length: 1096 Bit Score: 43.45 E-value: 1.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 763 AFGLESSGIAGTASDEPERIEESGTEEARPEGQAADEKKEPKEPREGGGAVEEEAKEEISEVPKKDEEKGkEGDSEKESE 842
Cdd:TIGR00927 626 ALGDLSKGDVAEAEHTGERTGEEGERPTEAEGENGEESGGEAEQEGETETKGENESEGEIPAERKGEQEG-EGEIEAKEA 704
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 843 KSDGDPIV---------DPEKDKEPTEGQEEVLKEVAEPEGE--------RKTKVERDIGEGNLSTAAAAALAAAAVKAK 905
Cdd:TIGR00927 705 DHKGETEAeevehegetEAEGTEDEGEIETGEEGEEVEDEGEgeaegkheVETEGDRKETEHEGETEAEGKEDEDEGEIQ 784
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1732634166 906 HLAAVEERKIKSLVALLVETQMKKLEIKLRHFEELETIMDREREALEYQRQQLLADRQ 963
Cdd:TIGR00927 785 AGEDGEMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDETGEQELNAENQ 842
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
722-974 |
3.44e-03 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 42.05 E-value: 3.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 722 AAAKSALEEFSKMKEEVPTAlvEAHVRKVEEAAKvtgKADPAFGLESsgiAGTASDEPERIEES-GTEEARP--EGQAAD 798
Cdd:PTZ00121 1466 AEEAKKADEAKKKAEEAKKA--DEAKKKAEEAKK---KADEAKKAAE---AKKKADEAKKAEEAkKADEAKKaeEAKKAD 1537
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 799 EKKEPKEPREGGGAVEEEAKEEISEVPKKDEEKGKEGDSEKESEKSDGDPIVDPEKDKEPTEGQEEVLKEVAE---PEGE 875
Cdd:PTZ00121 1538 EAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEeakKAEE 1617
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 876 RKTKVERDIGEGNLSTAAAAALAAAAVKAKHLAAV----EERKIKSlvallvETQMKKLEIKLRHFEELETIMDREREAL 951
Cdd:PTZ00121 1618 AKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELkkaeEENKIKA------AEEAKKAEEDKKKAEEAKKAEEDEKKAA 1691
|
250 260
....*....|....*....|...
gi 1732634166 952 EYQRQQLLADRQAfhmEQLKYAE 974
Cdd:PTZ00121 1692 EALKKEAEEAKKA---EELKKKE 1711
|
|
| Caldesmon |
pfam02029 |
Caldesmon; |
748-978 |
8.31e-03 |
|
Caldesmon;
Pssm-ID: 460421 [Multi-domain] Cd Length: 495 Bit Score: 40.24 E-value: 8.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 748 RKVEEAAKVTGKADPAFGLESSGIAgtasDEPERIEESGTEEARPEGQAADEKKEPKEpregggaveeeakEEISEVPKK 827
Cdd:pfam02029 77 KRLQEALERQKEFDPTIADEKESVA----ERKENNEEEENSSWEKEEKRDSRLGRYKE-------------EETEIREKE 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 828 D------------EEKG-KEGDSEKESEKSDGDPIVDPEKDKEPTEGQEEVLKEVAEPEGERKTKVERDIGEGNLSTAAA 894
Cdd:pfam02029 140 YqenkwstevrqaEEEGeEEEDKSEEAEEVPTENFAKEEVKDEKIKKEKKVKYESKVFLDQKRGHPEVKSQNGEEEVTKL 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 895 AALAAAAVKAKHLAAVEERKIKSlvalLVETQMKKLEIKLRH---------------------FEELETIMDREREALEY 953
Cdd:pfam02029 220 KVTTKRRQGGLSQSQEREEEAEV----FLEAEQKLEELRRRRqekeseefeklrqkqqeaeleLEELKKKREERRKLLEE 295
|
250 260
....*....|....*....|....*
gi 1732634166 954 QRQQllaDRQAFHMEQLKYAEMRAR 978
Cdd:pfam02029 296 EEQR---RKQEEAERKLREEEEKRR 317
|
|
| PRK10856 |
PRK10856 |
cytoskeleton protein RodZ; |
1156-1233 |
9.18e-03 |
|
cytoskeleton protein RodZ;
Pssm-ID: 236776 [Multi-domain] Cd Length: 331 Bit Score: 39.62 E-value: 9.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634166 1156 APGTIPPPNLPVSmANPLHPNLPATTTMPSSlplgpglgSAAAQSPAIVAAVQGNL------LPSASPLPDPGTPLPPDP 1229
Cdd:PRK10856 171 DPATTPAPAAPVD-TTPTNSQTPAVATAPAP--------AVDPQQNAVVAPSQANVdtaatpAPAAPATPDGAAPLPTDQ 241
|
....
gi 1732634166 1230 TAPS 1233
Cdd:PRK10856 242 AGVS 245
|
|
| |
