TBC1 domain family member 23 2 [Rattus norvegicus]
List of domain hits
Name | Accession | Description | Interval | E-value | ||||
TBC1D23_C | pfam19430 | TBC1 domain family member 23 C-terminal; TBC1 domain family member 23 (TBC1D23) belongs to a ... |
451-660 | 5.68e-155 | ||||
TBC1 domain family member 23 C-terminal; TBC1 domain family member 23 (TBC1D23) belongs to a family of TBC domain-containing Rab-specific GTPase-activating proteins, which plays a role in endosome-to-Golgi trafficking. It acts as a bridging factor in which the TBC domain binds to Golgi adaptor proteins golgin-97 and golgin-245 and its C-terminal to FAM21 subunit of the WASH complex, which regulates multiple endosomal trafficking routes. TBC1D23 is important for normal brain development, especially in axonal and dendritic growth. This entry represents the C-terminal domain that contains residues for specific FAM21 binding and for the cargo of endosome-derived carriers. It adopts a fold similar to the Pleckstrin homology (PH) domain. Mutations in this protein, and particularly in this domain, are linked with Pontocerebellar hypoplasia (PCH), suggesting that the TBC1D23 C-terminal domain is required for neuronal growth and brain development. : Pssm-ID: 437262 Cd Length: 225 Bit Score: 446.91 E-value: 5.68e-155
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RabGAP-TBC | pfam00566 | Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are ... |
79-246 | 7.62e-19 | ||||
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases. : Pssm-ID: 459855 Cd Length: 178 Bit Score: 84.61 E-value: 7.62e-19
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RHOD super family | cl00125 | Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese ... |
340-381 | 2.37e-04 | ||||
Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins such as sulfide dehydrogenases and certain stress proteins such as senesence specific protein 1 in plants, PspE and GlpE in bacteria and cyanide and arsenate resistance proteins. Inactive versions (no active site cysteine) are also seen in dual specificity phosphatases, ubiquitin hydrolases from yeast and in sulfuryltransferases, where they are believed to play a regulatory role in multidomain proteins. The actual alignment was detected with superfamily member pfam00581: Pssm-ID: 444705 [Multi-domain] Cd Length: 92 Bit Score: 40.55 E-value: 2.37e-04
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Name | Accession | Description | Interval | E-value | |||||
TBC1D23_C | pfam19430 | TBC1 domain family member 23 C-terminal; TBC1 domain family member 23 (TBC1D23) belongs to a ... |
451-660 | 5.68e-155 | |||||
TBC1 domain family member 23 C-terminal; TBC1 domain family member 23 (TBC1D23) belongs to a family of TBC domain-containing Rab-specific GTPase-activating proteins, which plays a role in endosome-to-Golgi trafficking. It acts as a bridging factor in which the TBC domain binds to Golgi adaptor proteins golgin-97 and golgin-245 and its C-terminal to FAM21 subunit of the WASH complex, which regulates multiple endosomal trafficking routes. TBC1D23 is important for normal brain development, especially in axonal and dendritic growth. This entry represents the C-terminal domain that contains residues for specific FAM21 binding and for the cargo of endosome-derived carriers. It adopts a fold similar to the Pleckstrin homology (PH) domain. Mutations in this protein, and particularly in this domain, are linked with Pontocerebellar hypoplasia (PCH), suggesting that the TBC1D23 C-terminal domain is required for neuronal growth and brain development. Pssm-ID: 437262 Cd Length: 225 Bit Score: 446.91 E-value: 5.68e-155
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TBC1D23_C-like | cd20788 | C-terminal domain of TBC1 domain family member 23, and similar proteins; This family contains ... |
564-678 | 1.32e-61 | |||||
C-terminal domain of TBC1 domain family member 23, and similar proteins; This family contains the C-terminal domain of Tre2-Bub2-Cdc16 (TBC) family 23 (TBC1D23), which adopts a Pleckstrin homology (PH) domain fold. It selectively binds to phosphoinositides, in particular, PtdIns(4)P, through one surface while it binds FAM21 via the opposite surface. TBC1D23, which is highly conserved in many eukaryotes but missing in plants and fungi, also possesses an N-terminal domain which is a catalytically inactive TBC domain. TBC1D23 encodes a protein functioning in endosome-to-Golgi trafficking in cells; it is a specificity determinant that links the vesicle to the target membrane. Homozygous mutations of TBC1D23 have been found in patients diagnosed with pontocerebellar hypoplasia (PCH), a group of neurological disorders that affect the brain development, particularly, the pons and cerebellum. Mutation of key residues of TBC1D23 (or FAM21) selectively disrupts the endosomal vesicular trafficking toward the Trans-Golgi Network. This C-terminal domain is missing in some PCH patients. Pssm-ID: 412053 Cd Length: 115 Bit Score: 200.93 E-value: 1.32e-61
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RabGAP-TBC | pfam00566 | Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are ... |
79-246 | 7.62e-19 | |||||
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases. Pssm-ID: 459855 Cd Length: 178 Bit Score: 84.61 E-value: 7.62e-19
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TBC | smart00164 | Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ... |
46-246 | 1.06e-13 | |||||
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases. Pssm-ID: 214540 [Multi-domain] Cd Length: 216 Bit Score: 70.80 E-value: 1.06e-13
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COG5210 | COG5210 | GTPase-activating protein [General function prediction only]; |
46-276 | 1.93e-07 | |||||
GTPase-activating protein [General function prediction only]; Pssm-ID: 227535 [Multi-domain] Cd Length: 496 Bit Score: 54.04 E-value: 1.93e-07
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Rhodanese | pfam00581 | Rhodanese-like domain; Rhodanese has an internal duplication. This Pfam represents a single ... |
340-381 | 2.37e-04 | |||||
Rhodanese-like domain; Rhodanese has an internal duplication. This Pfam represents a single copy of this duplicated domain. The domain is found as a single copy in other proteins, including phosphatases and ubiquitin C-terminal hydrolases. Pssm-ID: 425764 [Multi-domain] Cd Length: 92 Bit Score: 40.55 E-value: 2.37e-04
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DSP_MapKP | cd01446 | N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk ... |
328-439 | 3.75e-04 | |||||
N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by inducing a conformational change. This domain has homology to the Rhodanese Homology Domain. Pssm-ID: 238723 [Multi-domain] Cd Length: 132 Bit Score: 41.11 E-value: 3.75e-04
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glpE | PRK00162 | thiosulfate sulfurtransferase GlpE; |
327-365 | 8.25e-03 | |||||
thiosulfate sulfurtransferase GlpE; Pssm-ID: 178908 [Multi-domain] Cd Length: 108 Bit Score: 36.54 E-value: 8.25e-03
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Name | Accession | Description | Interval | E-value | |||||
TBC1D23_C | pfam19430 | TBC1 domain family member 23 C-terminal; TBC1 domain family member 23 (TBC1D23) belongs to a ... |
451-660 | 5.68e-155 | |||||
TBC1 domain family member 23 C-terminal; TBC1 domain family member 23 (TBC1D23) belongs to a family of TBC domain-containing Rab-specific GTPase-activating proteins, which plays a role in endosome-to-Golgi trafficking. It acts as a bridging factor in which the TBC domain binds to Golgi adaptor proteins golgin-97 and golgin-245 and its C-terminal to FAM21 subunit of the WASH complex, which regulates multiple endosomal trafficking routes. TBC1D23 is important for normal brain development, especially in axonal and dendritic growth. This entry represents the C-terminal domain that contains residues for specific FAM21 binding and for the cargo of endosome-derived carriers. It adopts a fold similar to the Pleckstrin homology (PH) domain. Mutations in this protein, and particularly in this domain, are linked with Pontocerebellar hypoplasia (PCH), suggesting that the TBC1D23 C-terminal domain is required for neuronal growth and brain development. Pssm-ID: 437262 Cd Length: 225 Bit Score: 446.91 E-value: 5.68e-155
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TBC1D23_C-like | cd20788 | C-terminal domain of TBC1 domain family member 23, and similar proteins; This family contains ... |
564-678 | 1.32e-61 | |||||
C-terminal domain of TBC1 domain family member 23, and similar proteins; This family contains the C-terminal domain of Tre2-Bub2-Cdc16 (TBC) family 23 (TBC1D23), which adopts a Pleckstrin homology (PH) domain fold. It selectively binds to phosphoinositides, in particular, PtdIns(4)P, through one surface while it binds FAM21 via the opposite surface. TBC1D23, which is highly conserved in many eukaryotes but missing in plants and fungi, also possesses an N-terminal domain which is a catalytically inactive TBC domain. TBC1D23 encodes a protein functioning in endosome-to-Golgi trafficking in cells; it is a specificity determinant that links the vesicle to the target membrane. Homozygous mutations of TBC1D23 have been found in patients diagnosed with pontocerebellar hypoplasia (PCH), a group of neurological disorders that affect the brain development, particularly, the pons and cerebellum. Mutation of key residues of TBC1D23 (or FAM21) selectively disrupts the endosomal vesicular trafficking toward the Trans-Golgi Network. This C-terminal domain is missing in some PCH patients. Pssm-ID: 412053 Cd Length: 115 Bit Score: 200.93 E-value: 1.32e-61
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RabGAP-TBC | pfam00566 | Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are ... |
79-246 | 7.62e-19 | |||||
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases. Pssm-ID: 459855 Cd Length: 178 Bit Score: 84.61 E-value: 7.62e-19
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TBC | smart00164 | Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ... |
46-246 | 1.06e-13 | |||||
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases. Pssm-ID: 214540 [Multi-domain] Cd Length: 216 Bit Score: 70.80 E-value: 1.06e-13
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COG5210 | COG5210 | GTPase-activating protein [General function prediction only]; |
46-276 | 1.93e-07 | |||||
GTPase-activating protein [General function prediction only]; Pssm-ID: 227535 [Multi-domain] Cd Length: 496 Bit Score: 54.04 E-value: 1.93e-07
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Rhodanese | pfam00581 | Rhodanese-like domain; Rhodanese has an internal duplication. This Pfam represents a single ... |
340-381 | 2.37e-04 | |||||
Rhodanese-like domain; Rhodanese has an internal duplication. This Pfam represents a single copy of this duplicated domain. The domain is found as a single copy in other proteins, including phosphatases and ubiquitin C-terminal hydrolases. Pssm-ID: 425764 [Multi-domain] Cd Length: 92 Bit Score: 40.55 E-value: 2.37e-04
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DSP_MapKP | cd01446 | N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk ... |
328-439 | 3.75e-04 | |||||
N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by inducing a conformational change. This domain has homology to the Rhodanese Homology Domain. Pssm-ID: 238723 [Multi-domain] Cd Length: 132 Bit Score: 41.11 E-value: 3.75e-04
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glpE | PRK00162 | thiosulfate sulfurtransferase GlpE; |
327-365 | 8.25e-03 | |||||
thiosulfate sulfurtransferase GlpE; Pssm-ID: 178908 [Multi-domain] Cd Length: 108 Bit Score: 36.54 E-value: 8.25e-03
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Blast search parameters | ||||
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