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Conserved domains on  [gi|1706865942|ref|NP_001358523|]
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major facilitator superfamily domain-containing protein 8 isoform 8 [Homo sapiens]

Protein Classification

MFSD8-like MFS transporter( domain architecture ID 13023588)

MFSD8-like major facilitator superfamily (MFS) transporter similar to MFS domain-containing protein 8, also called ceroid-lipofuscinosis neuronal protein 7 (CLN7), a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085|GO:0016020
PubMed:  26098515|26758938|26234418
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
 39-458 8.58e-140

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 405.82  E-value: 8.58e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942  39 IRILYLTMFLSSVGFSVVMMSIWPYLQKIDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRP-RKEPLIVSILISVAA 117
Cdd:cd17326     1 IYVMYLTMFLSSLQFSIVLTSIWPYLQKIDPTATASFFGWVVAAYSLGQLVFSPVFGYWSNKTSsVKEPLIVSILIAIVG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 118 NCLYAYLHIPASHNKYYMLVARGLLGIGAGNVAVVRSYTAGATSLQERTSSMANISMCQALGFILGPehrvddsGRQCKS 197
Cdd:cd17326    81 NILYALAEYFPSNRKYVMLVARFLIGVGAGNVAVLRAYVAAASTLKDRTRAMAVISAAQALGFIVGP-------ALQAAF 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 198 INFEEASTDEAQVPQGNIDQVAV--------------------VAINVLFFVTLFIFALFETIITPLTMDMYAWTQEQAV 257
Cdd:cd17326   154 TPIGYPGYVIGIKLRFNMYTAPAwlmailgiiniililfffkeVVCIFLFFVVLFIFANLETIGTPLTMDMYGWTREEAV 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 258 LYNGIILAALGVEAVVIFLGVKLLSKK-IGERAILLGGLIVVWVGFFILLPWGnqfpkiqwedlhnnsipnttfgeiiig 336
Cdd:cd17326   234 LYNGIILAVSGVLSVLVFLLFKFLSLGlIDERKILLGGLILFFLGFVVTLPWG--------------------------- 286

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 337 lwkspmeddnerptgcsieqawclytpvihlaqfLTSAVLIGLGYPVCNLMSYTLYSKILGPKPQGVYMGWLTASGSGAR 416
Cdd:cd17326   287 ----------------------------------ITGVILFGLGYPIGNVMLYTLYSKILGPKPQGTMQGVLTASGSLAR 332

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 1706865942 417 ILGPMFISQVYAHWGPRWAFSLVCGIIVLTITLLGVVYKRLI 458
Cdd:cd17326   333 TLGPIFVTAIYTHFGPRWTWIITLGLLLLAIILLIVFYKRLV 374
 
Name Accession Description Interval E-value
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
 39-458 8.58e-140

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 405.82  E-value: 8.58e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942  39 IRILYLTMFLSSVGFSVVMMSIWPYLQKIDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRP-RKEPLIVSILISVAA 117
Cdd:cd17326     1 IYVMYLTMFLSSLQFSIVLTSIWPYLQKIDPTATASFFGWVVAAYSLGQLVFSPVFGYWSNKTSsVKEPLIVSILIAIVG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 118 NCLYAYLHIPASHNKYYMLVARGLLGIGAGNVAVVRSYTAGATSLQERTSSMANISMCQALGFILGPehrvddsGRQCKS 197
Cdd:cd17326    81 NILYALAEYFPSNRKYVMLVARFLIGVGAGNVAVLRAYVAAASTLKDRTRAMAVISAAQALGFIVGP-------ALQAAF 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 198 INFEEASTDEAQVPQGNIDQVAV--------------------VAINVLFFVTLFIFALFETIITPLTMDMYAWTQEQAV 257
Cdd:cd17326   154 TPIGYPGYVIGIKLRFNMYTAPAwlmailgiiniililfffkeVVCIFLFFVVLFIFANLETIGTPLTMDMYGWTREEAV 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 258 LYNGIILAALGVEAVVIFLGVKLLSKK-IGERAILLGGLIVVWVGFFILLPWGnqfpkiqwedlhnnsipnttfgeiiig 336
Cdd:cd17326   234 LYNGIILAVSGVLSVLVFLLFKFLSLGlIDERKILLGGLILFFLGFVVTLPWG--------------------------- 286

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 337 lwkspmeddnerptgcsieqawclytpvihlaqfLTSAVLIGLGYPVCNLMSYTLYSKILGPKPQGVYMGWLTASGSGAR 416
Cdd:cd17326   287 ----------------------------------ITGVILFGLGYPIGNVMLYTLYSKILGPKPQGTMQGVLTASGSLAR 332

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 1706865942 417 ILGPMFISQVYAHWGPRWAFSLVCGIIVLTITLLGVVYKRLI 458
Cdd:cd17326   333 TLGPIFVTAIYTHFGPRWTWIITLGLLLLAIILLIVFYKRLV 374
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
33-310 2.00e-18

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 86.18  E-value: 2.00e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942  33 KSRWRSIRILYLTMFLSSVGFSVVMmSIWPYLQKiDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSIL 112
Cdd:COG2814     6 RRRWLALLALALGAFLSGLGIGIVL-PALPLIAA-DLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 113 ISVAANCLYAylhipASHNKYYMLVARGLLGIGAG-NVAVVRSYTAGATSLQERTSSMANISMCQALGFILGP------- 184
Cdd:COG2814    84 LFALGSLLCA-----LAPSLWLLLAARFLQGLGAGaLFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPllgglla 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 185 EHrvdDSGRQCKSIN--------------FEEASTDEAQVPQGNIDQV----AVVAINVLFFVTLFIFALFETIITPLTM 246
Cdd:COG2814   159 DL---FGWRWVFLVNavlallalllllrlLPESRPAARARLRGSLRELlrrpRLLLLLLLAFLLGFGFFALFTYLPLYLQ 235

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1706865942 247 DMYAWTQEQAvlynGIILAALGVEAVVIFLGVKLLSKKIGERAILLGGLIVVWVGFFILLPWGN 310
Cdd:COG2814   236 EVLGLSASAA----GLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGS 295
MFS_1 pfam07690
Major Facilitator Superfamily;
42-420 2.28e-12

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 67.83  E-value: 2.28e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942  42 LYLTMFLSSVGFSVVMMSIWPYLQKiDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAANCLY 121
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAE-DLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 122 AYlhipaSHNKYYMLVARGLLGIGAGNV-AVVRSYTAGATSLQERTSSMANISMCQALGFILGP---------------- 184
Cdd:pfam07690  80 LF-----ASSLWLLLVLRVLQGLGAGALfPAALALIADWFPPEERGRALGLVSAGFGLGAALGPllggllaslfgwraaf 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 185 ------------EHRVDDSGRQCKSINFEEASTDEAQVPQGNIDQVAVVAINVLFFVTLFIFALFETIItPLTMDMYAWT 252
Cdd:pfam07690 155 lilailsllaavLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYL-PLYQEVLGLS 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 253 QEQAVLYngIILAALGVEAVVIFLGVklLSKKIGERAILLGGLIVVWVGFFILLpwgnqfpkiqwedlhnnsipnttfge 332
Cdd:pfam07690 234 ALLAGLL--LGLGGLLGAIGRLLLGR--LSDRLGRRRRLLLALLLLILAALGLL-------------------------- 283

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 333 iiiglwkspmeddnerptgcsieqawcLYTPVIHLAQFLTSAVLIGLGYPVCNLMSYTLYSKILGPKPQGVYMGWLTASG 412
Cdd:pfam07690 284 ---------------------------LLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAG 336


                  ....*...
gi 1706865942 413 SGARILGP 420
Cdd:pfam07690 337 SLGGALGP 344
 
Name Accession Description Interval E-value
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
 39-458 8.58e-140

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 405.82  E-value: 8.58e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942  39 IRILYLTMFLSSVGFSVVMMSIWPYLQKIDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRP-RKEPLIVSILISVAA 117
Cdd:cd17326     1 IYVMYLTMFLSSLQFSIVLTSIWPYLQKIDPTATASFFGWVVAAYSLGQLVFSPVFGYWSNKTSsVKEPLIVSILIAIVG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 118 NCLYAYLHIPASHNKYYMLVARGLLGIGAGNVAVVRSYTAGATSLQERTSSMANISMCQALGFILGPehrvddsGRQCKS 197
Cdd:cd17326    81 NILYALAEYFPSNRKYVMLVARFLIGVGAGNVAVLRAYVAAASTLKDRTRAMAVISAAQALGFIVGP-------ALQAAF 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 198 INFEEASTDEAQVPQGNIDQVAV--------------------VAINVLFFVTLFIFALFETIITPLTMDMYAWTQEQAV 257
Cdd:cd17326   154 TPIGYPGYVIGIKLRFNMYTAPAwlmailgiiniililfffkeVVCIFLFFVVLFIFANLETIGTPLTMDMYGWTREEAV 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 258 LYNGIILAALGVEAVVIFLGVKLLSKK-IGERAILLGGLIVVWVGFFILLPWGnqfpkiqwedlhnnsipnttfgeiiig 336
Cdd:cd17326   234 LYNGIILAVSGVLSVLVFLLFKFLSLGlIDERKILLGGLILFFLGFVVTLPWG--------------------------- 286

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 337 lwkspmeddnerptgcsieqawclytpvihlaqfLTSAVLIGLGYPVCNLMSYTLYSKILGPKPQGVYMGWLTASGSGAR 416
Cdd:cd17326   287 ----------------------------------ITGVILFGLGYPIGNVMLYTLYSKILGPKPQGTMQGVLTASGSLAR 332

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 1706865942 417 ILGPMFISQVYAHWGPRWAFSLVCGIIVLTITLLGVVYKRLI 458
Cdd:cd17326   333 TLGPIFVTAIYTHFGPRWTWIITLGLLLLAIILLIVFYKRLV 374
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 42-452 1.62e-58

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 196.26  E-value: 1.62e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942  42 LYLTMFLSSVGFSVVMMSIWPYLQKI-DPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAANCL 120
Cdd:cd17330     1 LFLVVFLDALGFGIVFPVLPFYVREFnKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 121 YAYlhipaSHNKYYMLVARGLLGIGAGNVAVVRSYTAGATSLQERTSSMANISMCQALGFILGPEHrvddSGRQCKSINF 200
Cdd:cd17330    81 LGL-----SRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPAL----GGFLSTPYGY 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 201 EEASTDEAQVPQGNI--DQVAVVAINVLFFVTLFI---FALFETIITPLTMDMYAWTQEQAvlynGIILAALGVEAVVIF 275
Cdd:cd17330   152 ALPFLVAAALALLNLvlVLFFLPPLRRLLLVYFLIalaFAGLESVFSLFLKDRFGFSPSQI----GLLLALVGIAGILAQ 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 276 LGV-KLLSKKIGERAILLGGLIVVWVGFFiLLPWGNQFPkiqwedlhnnsipnttfgeiiiglwkspmeddnerptgcsi 354
Cdd:cd17330   228 LLLiPRLAKRLGERKLLRLGLLLAIIGLL-LLPFASSVP----------------------------------------- 265

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 355 eqawclytpvihlaQFLTSAVLIGLGYPVCNLMSYTLYSKILGPKPQGVYMGWLTASGSGARILGPMFISQVYAHWGPRW 434
Cdd:cd17330   266 --------------LLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGV 331

                         410
                  ....*....|....*...
gi 1706865942 435 AFSLVCGIIVLTITLLGV 452
Cdd:cd17330   332 PFLLAAGLLLIALFLLSL 349
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 42-455 4.85e-20

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 91.48  E-value: 4.85e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942  42 LYLTMFLSSVGFSVVMMSIWPYLQKIDptADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAANCLY 121
Cdd:cd17325     1 LSLALFLDMLGYGIIIPILPLYAESLG--ASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLF 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 122 AYLHIPashnkYYMLVARGLLGIGAGNVAVVR-SYTAGATSLQERTSSMANISMCQALGFILGP-------EHR------ 187
Cdd:cd17325    79 AFATSY-----WQLLLARFLQGLASAAVWPAAmALIADIAPPEERGRAMGIFSSAIGLGFLIGPllggllaDALgyrapf 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 188 -----------------VDDSGRQCKSInfEEASTDEAQVPQGNIDQVAVVAINVLFFVTLFIFALFETIITPLTMDMYA 250
Cdd:cd17325   154 lvcaalallalvlalllLPEPRPPPNKR--AVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGG 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 251 WTQEQAvlynGIILAALGVEAVVIFLGVKLLSKKIGERAILLGGLIVVwVGFFILLPWGNQFPkiqwedlhnnsipnttf 330
Cdd:cd17325   232 LSPAQI----GLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLS-AVALLLLPLATSFW----------------- 289

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 331 geiiiglwkspmeddnerptgcsieqawclytpvihlaQFLTSAVLIGLGYPVCNLMSYTLYSKILGPKPQGVYMGWLTA 410
Cdd:cd17325   290 --------------------------------------LLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNT 331

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 1706865942 411 SGSGARILGPMFISQVYAHWGPRWAFsLVCGIIVLTITLLGVVYK 455
Cdd:cd17325   332 AFSLGMVLGPLLGGFLYDAFGFATPF-LAAAALLLLAAVLFLLLR 375
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
33-310 2.00e-18

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 86.18  E-value: 2.00e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942  33 KSRWRSIRILYLTMFLSSVGFSVVMmSIWPYLQKiDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSIL 112
Cdd:COG2814     6 RRRWLALLALALGAFLSGLGIGIVL-PALPLIAA-DLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 113 ISVAANCLYAylhipASHNKYYMLVARGLLGIGAG-NVAVVRSYTAGATSLQERTSSMANISMCQALGFILGP------- 184
Cdd:COG2814    84 LFALGSLLCA-----LAPSLWLLLAARFLQGLGAGaLFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPllgglla 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 185 EHrvdDSGRQCKSIN--------------FEEASTDEAQVPQGNIDQV----AVVAINVLFFVTLFIFALFETIITPLTM 246
Cdd:COG2814   159 DL---FGWRWVFLVNavlallalllllrlLPESRPAARARLRGSLRELlrrpRLLLLLLLAFLLGFGFFALFTYLPLYLQ 235

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1706865942 247 DMYAWTQEQAvlynGIILAALGVEAVVIFLGVKLLSKKIGERAILLGGLIVVWVGFFILLPWGN 310
Cdd:COG2814   236 EVLGLSASAA----GLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGS 295
MFS_1 pfam07690
Major Facilitator Superfamily;
42-420 2.28e-12

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 67.83  E-value: 2.28e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942  42 LYLTMFLSSVGFSVVMMSIWPYLQKiDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAANCLY 121
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAE-DLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 122 AYlhipaSHNKYYMLVARGLLGIGAGNV-AVVRSYTAGATSLQERTSSMANISMCQALGFILGP---------------- 184
Cdd:pfam07690  80 LF-----ASSLWLLLVLRVLQGLGAGALfPAALALIADWFPPEERGRALGLVSAGFGLGAALGPllggllaslfgwraaf 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 185 ------------EHRVDDSGRQCKSINFEEASTDEAQVPQGNIDQVAVVAINVLFFVTLFIFALFETIItPLTMDMYAWT 252
Cdd:pfam07690 155 lilailsllaavLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYL-PLYQEVLGLS 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 253 QEQAVLYngIILAALGVEAVVIFLGVklLSKKIGERAILLGGLIVVWVGFFILLpwgnqfpkiqwedlhnnsipnttfge 332
Cdd:pfam07690 234 ALLAGLL--LGLGGLLGAIGRLLLGR--LSDRLGRRRRLLLALLLLILAALGLL-------------------------- 283

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 333 iiiglwkspmeddnerptgcsieqawcLYTPVIHLAQFLTSAVLIGLGYPVCNLMSYTLYSKILGPKPQGVYMGWLTASG 412
Cdd:pfam07690 284 ---------------------------LLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAG 336


                  ....*...
gi 1706865942 413 SGARILGP 420
Cdd:pfam07690 337 SLGGALGP 344
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 42-184 3.16e-12

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 67.64  E-value: 3.16e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942  42 LYLTMFLSSVGFSVVMMSIWPYLQKIDptADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILIsvaanCLY 121
Cdd:cd17390     1 LYLVGFLDLFGVSMILPLLSTHIRSLG--ASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLL-----TAL 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1706865942 122 AYLHIPASHNKYYMLVARGLLGIGAGNVAVVRSYTAGATSLQERTSSMANISMCQALGFILGP 184
Cdd:cd17390    74 GYVLLGFSTSLALLFLSRIPLGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGP 136
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 35-184 4.01e-10

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 61.44  E-value: 4.01e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942  35 RWRSIRILYLTMFLSSVGFSVVMMSIWPYLQKIDpTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILIS 114
Cdd:cd17325   197 RDRRLLALFLAIFVLAFAFGALEPFLPLYAAELG-GLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLS 275

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1706865942 115 VAanclyAYLHIPASHNKYYMLVARGLLGIGAGNV-AVVRSYTAGATSLQERTSSMANISMCQALGFILGP 184
Cdd:cd17325   276 AV-----ALLLLPLATSFWLLLLLLALLGLGLGLVfPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGP 341
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 39-450 1.35e-09

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 59.57  E-value: 1.35e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942  39 IRILYLTMFLSSVGFSVvMMSIWPYL--QKIDPTAD-TSFLGWVIASYSLGQMVASPIFGLWSNYRPRKePLIVSILISV 115
Cdd:cd17388     1 LIFILVTVLLDAMGIGL-IMPVLPTLlrEFVGDSADaATHYGVLLALYALMQFIFAPILGALSDRFGRR-PVLLLSLAGA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 116 AANclyaYLHIPASHNKYYMLVARGLLGIGAGNVAVVRSYTAGATSLQERTSSMANISMCQALGFILGP-------EHrv 188
Cdd:cd17388    79 ALD----YLLMAFAPTLWWLYLGRIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPalggllgEI-- 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 189 ddSGRQ-------CKSINF-------EEASTDEAQV--------PQGNIDQVAVVAINVLFFVTLFIFALFETIITPL-- 244
Cdd:cd17388   153 --SPRApflvaagLNGLNFllglfvlPESLPPERRRafrwrranPFGSLRWLTGFPGLLGLLAVFFLIQLIGQVPATTwv 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 245 --TMDMYAWTQEQavlyNGIILAALGVEAVVI-FLGVKLLSKKIGERAILLGGLIVVWVGFFILlpwgnqfpkiqwedlh 321
Cdd:cd17388   231 lfTEDRFDWSPTM----VGLSLAVFGLLHALFqAFVTGPIAKRLGEKRAILLGLAADALGFLLL---------------- 290

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 322 nnsipnttfgeiiiglwkspmeddnerptgCSIEQAWCLYTPVIHLAqfltsavLIGLGYPVCNlmsyTLYSKILGPKPQ 401
Cdd:cd17388   291 ------------------------------AFATQGWMVFPILILLA-------LGGIAGPALQ----GLLSRQVPENEQ 329

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1706865942 402 GVYMGWLTASGSGARILGPMFISQVYA----HWgPRWAFSLVCGIIVLTITLL 450
Cdd:cd17388   330 GELQGVLTSLTSLTSIIGPLLFTGIFAaspaTW-PGLAWIIGAALYLICLVLA 381
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 33-184 4.74e-09

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 57.51  E-value: 4.74e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942  33 KSRWRSIRILYLTMFLSSVGFSVVMMSIwPYLQKiDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSIL 112
Cdd:COG0477    10 RRRRRALLALALGTFLEGLDFTIVNVAL-PSIAA-DLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLL 87

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1706865942 113 ISVAANCLYAYLHIPAShnkyyMLVARGLLGIGAG-NVAVVRSYTAGATSLQERTSSMANISMCQALGFILGP 184
Cdd:COG0477    88 LFGLASLLCGLAPSPEL-----LIAARALQGIGAGgLMPGALALIAELFPARERGRALGLWGAAIGLGLALGP 155
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 44-450 4.26e-08

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 55.13  E-value: 4.26e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942  44 LTMFLSSVGFSVVMMS-IWPYLQKiDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAANCLYA 122
Cdd:cd06174     1 LLLGFFLTGLARGLISpLLPALLQ-SFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 123 YLHIPAShnkyyMLVARGLLGIGAGNVAVVR-SYTAGATSLQERTSSMANISMCQALGFILGP------EHRVDDSGRQC 195
Cdd:cd06174    80 FAPSFWL-----LLLGRFLLGLGSGLIDPAVlALIADLFPERERGRALGLLQAFGSVGGILGPllggilASSLGFGWRAV 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 196 -------------------KSINFEEASTDEAQVPQGNIDQVAVVAINVLFFVTLFIFALFETIITPLTMDMYAWTQEQA 256
Cdd:cd06174   155 fliaaalallaaillllvvPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLG 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 257 VL----YNGIILAALGVEAVVIFLGVKLLSKKIGERAILLGGLIVVWVGFFILLPWGnqfpkiqwedlhnnsipnttfge 332
Cdd:cd06174   235 GLsvavAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAP----------------------- 291

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 333 iiiglwkspmeddnerptgcsieqawclytpviHLAQFLTSAVLIGLGYPVCNLMSYTLYSKILGPKPQGVYMGWLTASG 412
Cdd:cd06174   292 ---------------------------------SLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFG 338

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 1706865942 413 SGARILGPMFISQVYA-HWGPRWAFSLVCGIIVLTITLL 450
Cdd:cd06174   339 FLGGAIGPLLAGFLLAaTFGLTGAFLVLAVLLLLAAILL 377
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
33-457 1.03e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 53.72  E-value: 1.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942  33 KSRWRSIRILYLTMFLSSVGFSVVMMsIWPYLQK---IDPTAdtsfLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIV 109
Cdd:COG2271     6 RYRWRILALLFLAYFLNYLDRSNLSV-AAPPLQAdlgLSAAQ----LGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 110 SILISVAANCLYAYlhipaSHNKYYMLVARGLLGIG-AGNVAVVRSYTAGATSLQERTSSMANISMCQALGFILGPehrv 188
Cdd:COG2271    81 GLLLWGLATLLFGF-----ATSFWQLLLLRFLLGLGeAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAP---- 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 189 ddsgrqcksinfeeastdeaqVPQGNIDQ--------------------VAVVAINVLFFVTLFIFALFETIITPLTMDM 248
Cdd:COG2271   152 ---------------------PLLGWLLAafgwraaflilglpglllalLRFWLLALAYFLVYFALYGFLTWLPTYLVEV 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 249 YAWTQEQAVLYNGIILAAlgveAVVIFLGVKLLSKKIGERaillgGLIVVWVGFFILLPwgnqfpkiqwedlhnnsipnt 328
Cdd:COG2271   211 RGLSLAQAGLLLSLPFLA----GIVGSLLGGWLSDRLGRR-----RKLVLAIGLLLAAL--------------------- 260

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 329 tfgeiiiglwkspmeddnerptgcsieqAWCLYTPVIHLAQFLTSAVLIGLGYPVCNLMSYTLYSKILGPKPQGVYMGWL 408
Cdd:COG2271   261 ----------------------------ALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLV 312

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 1706865942 409 TASGSGARILGPMFISQVYAHWGPRWAFSLVCGIIVLTITLLGVVYKRL 457
Cdd:COG2271   313 NTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRET 361
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 59-184 1.55e-07

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 53.43  E-value: 1.55e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942  59 SIWPYLQKIDPTA--DTSFLGWVIAS-YSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAANCLYAylhipASHNKYYM 135
Cdd:cd17389    46 DWFRDAIGAPDERryNSVLFGGLIGSlFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAISYALWA-----VSRSFTIF 120

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1706865942 136 LVARGLLGIGAGNVAVVRSYTAGATSLQERTSSMANISMCQALGFILGP 184
Cdd:cd17389   121 LLSRIVGGISKGNVSLSTAIVADVTSPKKRSKGMALIGVAFSLGFIIGP 169
Sugar_tr pfam00083
Sugar (and other) transporter;
71-147 1.07e-06

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 50.73  E-value: 1.07e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1706865942  71 ADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAANCLyayLHIPASHNKYYML-VARGLLGIGAG 147
Cdd:pfam00083  43 ALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVL---QGAAKGKWSVYQLiVGRVLVGIGVG 117
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 38-305 4.28e-06

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 48.75  E-value: 4.28e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942  38 SIRILYLTMFLSSVGFSVvMMSIWPYL-QKIDptADTSFLGWVIASYSLGQMVASPIFGLWSN-YRPRKEpLIVSILisv 115
Cdd:cd17331     1 VLLIVHLNIVLYATCYWL-QQPVLPYLtKKLG--VDSVVFGYLQTTFSVLQLVGGPLFGRFGDlFGPRAA-LVLSFL--- 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 116 AANCLYAYLhipASHNKYYMLVARGLLGIGAGNVAVVRSYTAGATSLQERTSSMANISMCQALGFILGP------EHRVD 189
Cdd:cd17331    74 SSALSYLLL---AFASSVPMLFLSRLPSVFMHAMQAAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSflggllTKKFG 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 190 DSGRQ-----------CKSINFEEASTDEAQVPQGNIDQVAVVAINVLFFVTL-----------------FIFALFETII 241
Cdd:cd17331   151 EQAAAlvaavgsllsiVLVILLIPSNTKSKREKEAKESASPPSVFNLKEILRLlrlpgvaflllvkllsgLPIGMFQSMF 230

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1706865942 242 TPLTMDMYAWTQEQavlyNGIILAALGV-EAVVIFLGVKLLSKKIGERAILLGGLIVVWVGFFIL 305
Cdd:cd17331   231 SLVAMDFFGLTPEE----NGYLMSYAGVlGMVVQGLLVGPLTKRFGERSLLKLSVALLAIGYLLL 291
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 41-305 4.77e-06

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 48.72  E-value: 4.77e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942  41 ILYLTMFLSSVGFSVVMMSIwPYLQKIDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAANCL 120
Cdd:cd17473     3 TLLLASTLTVMAGAAIAPAL-PAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 121 YAYLhipashNKYY-MLVARGLLGIGAGNVAVVrsytagATSL-------QERTSSMANISMCQALG------------- 179
Cdd:cd17473    82 GLFL------DSLYaLLASRALLGIGVAGIMTL------ATALigdyfegEERAKMLGLQSAAMSLGgvvflllggalae 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 180 -------------FILGP------EHRVDDSGRQCKSINFEEASTDeaqvpqgnidqvaVVAINVLFFVTLFIFALFETI 240
Cdd:cd17473   150 igwrapflvyllaLPVLIlvllflPEPARKSKSAASPGAATAAALP-------------WKRVLPIYFLAFLAMLLFYVI 216

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1706865942 241 ITPLTMDMYAwTQEQAVLYNGIILAALGVEAVVIFLGVKLLSKKIGERAILLGGLIVVWVGFFIL 305
Cdd:cd17473   217 PIQLPFLLQE-RGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLL 280
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 36-184 8.32e-06

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 47.95  E-value: 8.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942  36 WRSIRILYLTMFLSSVGFSVVMMSIWPYLQKIDpTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPrKEPLIVSILISV 115
Cdd:cd17473   196 WKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERG-GGSAALIGLALAIASLAGAIGALLFGRLKRRLG-KRRLLAIGFALM 273

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 116 AAnclyAYLHIPASHNKYYMLVARGLLGIGAG-NVAVVRSYTAGATSLQERTSSMANISMCQALGFILGP 184
Cdd:cd17473   274 AL----GFLLLALASGLWVVLLGAILAGLGFGlLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSP 339
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
35-179 1.17e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 47.28  E-value: 1.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942  35 RWRSIRILYLTMFLSSVGFSVVMMSIWPYLQKIdPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILIS 114
Cdd:COG2814   205 RRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEV-LGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLL 283

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1706865942 115 VAANCLYAYLHIPAShnkyyMLVARGLLGIGAG-NVAVVRSYTAGATSLQERTSSMANISMCQALG 179
Cdd:COG2814   284 ALGLLLLALAGSLWL-----LLLALFLLGFGFGlLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 77-183 1.55e-05

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 46.77  E-value: 1.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942  77 GWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAANCLYAylhipASHNKYYMLVARGLLGIGAGNV-AVVRSY 155
Cdd:cd17324    37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAA-----LAPSFALLLLARALAGLAHGGFwAIAAAY 111

                          90       100
                  ....*....|....*....|....*...
gi 1706865942 156 TAGATSLQERTSSMANISMCQALGFILG 183
Cdd:cd17324   112 AADLVPPEKRGRAIGLVFSGLTLGLVLG 139
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
33-310 2.69e-05

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 46.39  E-value: 2.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942  33 KSRWRSIRILYLTMFLSSVGFSVVMmSIWPYLQKIDpTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSIL 112
Cdd:COG0738     4 KNYRRALIAIYLLFFLWGFATALWG-PLIPALKDAF-GLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 113 ISVAANCLYAYlhipaSHNKYYMLVARGLLGIGAG--NVAVvrsyTAGATSLQERTSSmANISMCQA---LGFILGP--- 184
Cdd:COG0738    82 LMALGLLLFAL-----APSYPLLLLALFLLGLGLGllDVAA----NPYVAALGPETAA-SRLNLLHAffsLGALLGPllg 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 185 ----EHRVDDSGRQ---------------CKSINFEEASTDEAQVPQGNIDQVAVVAIN--VLFFVTLFIFALFETIITP 243
Cdd:COG0738   152 glliLLGLSLSWHLpylilavlllllallFLRSKLPEIEEEEEEAAGSAASLKSLLKNPrlLLGGLAIFLYVGAEGAIGD 231

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1706865942 244 LT----MDMYAWTQEQAVLYNGIILAALgveAVVIFLGVKLLsKKIGERAILLGGLIVVWVGFFILLPWGN 310
Cdd:COG0738   232 WLplylKDVLGLSEATAALGLSLFWGGM---TIGRFLGGFLL-KRFGPVRLLRLSALLAAVGLLLALLAPG 298
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 39-450 3.08e-05

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 46.07  E-value: 3.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942  39 IRILYLTMFLSSVGFSVVM--MSIWPYLQKIDPTadtSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVA 116
Cdd:cd17329     1 LWVLLIGSFLNRLGFFMVWpfMAIYLHQQLGLSA---SIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRAL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 117 ANCLYAYLHIPAshnkyymLVARGLLGIGAGN---VAVVRSYTAGATSLQERTSSMANISMCQALGFILGP---EHRVDD 190
Cdd:cd17329    78 GFALLGFAHSPW-------LFAIALVLTGFGGglfEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPllgGLLLLY 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 191 SGRQ--------------CKSINFEEASTDEAQVPQGNIDQV--------AVVAINVLFFVTLFIFALFETIITPLTMDM 248
Cdd:cd17329   151 SFRLlflaaavlfllaalVLLFLLPETRPKRRAAEKTEILRGykivlrdrAFLLFLLASFLISLIYFQLESTLPVYVVEI 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 249 YAWTQEQAvlynGIILAALGVEAVVIFLGVKLLSKKIGERAILLGGLIVVWVGFFIlLPWGNQFPkiqwedlhnnsipnt 328
Cdd:cd17329   231 LGLGESLL----GLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAV-LAFANTLA--------------- 290

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 329 tfgeiiiglwkspmeddnerptgcsieqawclytpvihlaQFLTSAVLIGLGYPVCNLMSYTLYSKILGPKPQGVYMGWL 408
Cdd:cd17329   291 ----------------------------------------VLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFY 330

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 1706865942 409 TASGSGARILGPMFISQVYAHWGPRWAFsLVCGIIVLTITLL 450
Cdd:cd17329   331 ALAWGLGRAIGPLVGGLLLDLLGPGLPW-LILAALGLIAAAL 371
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 44-338 4.25e-05

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 45.63  E-value: 4.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942  44 LTMFLSSVGFSVVMMSIwPYLQKiDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAANCLYAY 123
Cdd:cd17321     3 LAVFLAALDVTIVNVAL-PTIAR-DLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 124 lhipaSHNKYYMLVARGLLGIGAG-----NVAVVRSYTAGAtslqERTSSMANISMCQALGFILGP-------EHrvdDS 191
Cdd:cd17321    81 -----APSLAFLIAARALQGIGAAaimpaSLALIAATFPGE----RRGRALGLWGAVVGIGAALGPllgglllEL---FG 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 192 GRQCKSINfeeastdeaqVPqgnidqVAVVAI---------NVLFFVTLFIFALFETIITPLTMDMYAWTQEQAvlynGI 262
Cdd:cd17321   149 WRWIFLIN----------VP------IGLVALllartfsgaVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQA----GL 208

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1706865942 263 ILAALGVE-AVVIFLGVKLLsKKIGERAILLGGLIVVWVGFFILLPWGnqfpkiqwedlHNNSIPNTTFGEIIIGLW 338
Cdd:cd17321   209 ALLPLALAmLVAAPLAGRLA-DRFGPRLVLVAGLLLTAVGLLLLALLG-----------ADSSVWLLLPGLVLLGLG 273
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 42-306 5.96e-05

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 44.86  E-value: 5.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942  42 LYLTMFLSSVGFSVVMMSIwpylqkidPT-----ADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVA 116
Cdd:cd17502     1 LMLALFLAALDQTIVATAL--------PTivaefGGLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFEL 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 117 ANCLYAylhipASHNKYYMLVARGLLGIGAGNVAVVrSYTAGA--TSLQERTSSMANISMCQALGFILGP-------EHR 187
Cdd:cd17502    73 GSLLCG-----LAPNMTMLIVGRAIQGIGGGGLMSL-AFIIIAdlVPPRERGKYQGYIGAVFGIASVAGPliggaftDHL 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 188 vddSGRQCKSINfeeastdeaqVPQGNIDQVAVVAINVLFFVTLFIFALFETIITPLTMdMYAWTQEQAVLYNGIILAAL 267
Cdd:cd17502   147 ---SWRWCFYIN----------LPIGGLALALLRTILLSSIFGFLFGGALFGLIYYLPL-YFQLVLGDSATKSGVRLLPL 212

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1706865942 268 GVEAVV-IFLGVKLLSKKIGERAILLGGLIVVWVGFFILL 306
Cdd:cd17502   213 IIGLVIgSIISGALISKTGRYKPLIVIGTILMSVGAGLLT 252
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
37-184 7.26e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 44.89  E-value: 7.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942  37 RSIRILYLTMFLSSVGFSVVMMSIwPYLQKIDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVA 116
Cdd:COG2211   228 RPFLLLLLAYLLFFLALALVAALL-LYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAAL 306

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1706865942 117 ANCLYAYLHipaSHNKYYMLVARGLLGIGAGNVAVV-RSYTAGATSLQERTSS-------MANISMCQALGFILGP 184
Cdd:COG2211   307 GLLLLFFLG---PGNLWLLLVLAALAGIGLGAILVLpWAMLADVVDYDEWKTGrrreglyFGIFTFAIKLGQALAG 379
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
366-450 8.80e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 44.58  E-value: 8.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 366 HLAQFLTSAVLIGLGYPVCNLMSYTLYSKILGPKPQGVYMGWLTASGSGARILGPMFISQVYAHWGPRWAFsLVCGIIVL 445
Cdd:COG2814    97 SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVF-LVNAVLAL 175


                  ....*
gi 1706865942 446 TITLL 450
Cdd:COG2814   176 LALLL 180
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 30-184 9.46e-05

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 44.34  E-value: 9.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942  30 EHYKSRWRSIRILYLTMFLSSVGFSVV-MMSIWPYLQKIDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLI 108
Cdd:cd06174   194 KLLKRVLKNPGLWLLLLAIFLVNLAYYsFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLL 273

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1706865942 109 VSILISVAANCLYAYLHIPashnKYYMLVARGLLGIGAGNVAVVR-SYTAGATSLQERTSSMANISMCQALGFILGP 184
Cdd:cd06174   274 LIGLLLMALGLALLLLAPS----LLLLLLLLLLLGFGLGGLLPLSfALIAELFPPEIRGTAFGLLNTFGFLGGAIGP 346
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 42-184 1.61e-04

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 43.74  E-value: 1.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942  42 LYLTMFLSSVGFSVVMMSIWPYLQKIDPTADTSflGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAANCLY 121
Cdd:cd17489     1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVA--GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLY 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1706865942 122 AYLHIPAShnkyyMLVARGLLGIGAGNVAVVRS-YTAGATSLQERTSSMANISMCQALGFILGP 184
Cdd:cd17489    79 LLATSVAL-----LLVLRLIHGIGWGAFTTAAAtLVADIIPPSRRGEGIGYYGLATTLAMALGP 137
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 42-184 4.57e-04

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 42.15  E-value: 4.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942  42 LYLTMFLSSVGFSVVM--MSIW--PYLQkidptADTSFLGWVIASYSLGQMVASPIFGLWSNYR-PRKEPLIVSILISVA 116
Cdd:cd17471     1 LLLATLLTGLAGAFVLpyLSLFltEELG-----ASPLQIGIFMTLSALSGIVVSQWLGRLSDRGgDRKPLILLALLAGAL 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1706865942 117 ANCLYAYLHIpashnkYYMLVARGLLGIGAGNVAV------VRSYtAGATSLQERTSSMANISMCQALGFILGP 184
Cdd:cd17471    76 GYLLFAFLRN------YWVLLLVGVVLLSLGAAAFpqlfalAREY-ADRSSGRDATLFNSVLRAAFSLAWVIGP 142
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 42-311 4.64e-04

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 42.17  E-value: 4.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942  42 LYLTMFLSSVGFSVVMM--SIWPYLQKiDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAANC 119
Cdd:cd17474     1 LYAVFFATLLAVLGVSIvdPILPAIAE-ALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 120 LYAylhipASHNKYYMLVARGLLGIGAG-----NVAVVRSYTAGAtslqERTSSM----ANISMCQALGFILG------- 183
Cdd:cd17474    80 LCG-----LSDSFALLLAGRALQGIGAAglgplALTLIGDLFEGG----ERAKAMglyeAALGLGIAVGPLLGgllaais 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 184 ------------------------PEHRVDDSGRQCKSINFEEASTDEAqvpqgnidqvavvaINVLFFVTLFIFALFET 239
Cdd:cd17474   151 wrypffllaalipvaflailfllpEPKEKAKSSSATKLRDLKKALRGRG--------------LLTFLVSAFLYFFLYFA 216

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1706865942 240 IIT--PLTMDMyawTQEQAVLYNGIILAALGVE-AVVIFLGVKLLSKKIGERAILLGGLIVVWVGFFILLPWGNQ 311
Cdd:cd17474   217 FLTylPFLLEL---LYGISPIIIGLLFAGWSVLlALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSL 288
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 360-453 5.92e-04

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 41.81  E-value: 5.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 360 LYTPVIHLAQFLTSAVLIGLGYPVCNLMSYTLYSKILGPKPQGVYMGWLTASGSGARILGPMFISQVYAHWGPRWAFSLV 439
Cdd:cd17489    77 LYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVA 156

                          90
                  ....*....|....
gi 1706865942 440 CGIIVLTITLLGVV 453
Cdd:cd17489   157 AVLALLALLLVFLV 170
MFS_1 pfam07690
Major Facilitator Superfamily;
37-184 6.58e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 41.63  E-value: 6.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942  37 RSIRILYLTMFLSSVGFSVVMMSIWPYLQKIDptADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVA 116
Cdd:pfam07690 200 DPVLWLLLALLLFGFAFFGLLTYLPLYQEVLG--LSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLIL 277

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1706865942 117 ANCLYAYLHIPASHNKYYMLVArgLLGIGAG-NVAVVRSYTAGATSLQERTSSMANISMCQALGFILGP 184
Cdd:pfam07690 278 AALGLLLLSLTLSSLWLLLALL--LLGFGFGlVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 37-162 1.16e-03

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 41.02  E-value: 1.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942  37 RSIRILYLTMFLSSVGFSVVMMSIWPYLQkiDPTADTSFL-----GWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSI 111
Cdd:cd17504   177 RNVLLANITALLAGFGMFMVFQLLPQLLQ--LPTPTGFGLgiteaGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGL 254

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1706865942 112 LISVAANCLYAYLHIPASHnkyyMLVARGLLGIGAGN----------VAVVRSYTAGATSL 162
Cdd:cd17504   255 VISAVGLLLLALLHSSLWA----LVVALLLIGIGLGLafaslpnivvESVPPDRTGIATGM 311
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 37-184 1.25e-03

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 41.00  E-value: 1.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942  37 RSIRILYLTMFLSSVGFSVVMMSIWPYLQKIdPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVA 116
Cdd:cd17324   198 PRLRLAYLITFLLFGGFFALYTYLAPFLTDV-PGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAA 276

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1706865942 117 ANCLYAYLHIPAShnkyyMLVARGLLGIGAGNVAVVRSYTAGATSLQERTSSMANISMCQALGFILGP 184
Cdd:cd17324   277 LLLLTLLGPSPLL-----LLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYNLGGALGA 339
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 72-152 1.68e-03

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 40.64  E-value: 1.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942  72 DTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAANCLYAylhipASHNKYYMLVARGLLGIGAGNVAV 151
Cdd:cd17315    32 STSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSA-----LAPNVWVLIVGRFLLGLGVGLASV 106


                  .
gi 1706865942 152 V 152
Cdd:cd17315   107 L 107
MFS_1 pfam07690
Major Facilitator Superfamily;
357-450 1.86e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 40.48  E-value: 1.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 357 AWCLYTPVIHLAQFLTSAVLIGLGYPVCNLMSYTLYSKILGPKPQGVYMGWLTASGSGARILGPMFISQVYAHWGPRWAF 436
Cdd:pfam07690  75 GLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAF 154

                          90
                  ....*....|....
gi 1706865942 437 SLVCGIIVLTITLL 450
Cdd:pfam07690 155 LILAILSLLAAVLL 168
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 37-183 2.20e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 40.23  E-value: 2.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942  37 RSIRILYLTMFLSSVGFSVVMMSIWPYLQKIDPtADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVA 116
Cdd:cd17321   168 RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLG-YSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAV 246

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 117 ANCLYAYLHIPAShnKYYMLVARGLLGIGAGNVAVVRSYTAGATSLQERT---SSMANisMCQALGFILG 183
Cdd:cd17321   247 GLLLLALLGADSS--VWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAgaaSGILN--TARQLGGALG 312
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
225-456 2.37e-03

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 40.25  E-value: 2.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 225 VLFFVTLFIFALFETIITPLTMDMYAWTQEQAVLYNGI--ILAALGVeavvIFLGVklLSKKIGERAILLGGLIVVWVGF 302
Cdd:COG2223   212 LLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALfaLLGALGR----PLGGW--LSDRIGGRRVLLIVFALMALGL 285

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942 303 FILLPWGNQFPkiqwedlhnnsipnttfgeiiiglwkspmeddnerptgcsieqawclytpvihlaQFLTSAVLIGLGYP 382
Cdd:COG2223   286 LLLALALGSLW-------------------------------------------------------LFLVLFLLLGLALG 310

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1706865942 383 VCNLMSYTLYSKILGPKPQGVYMGWLTASGSGARILGPMFISQVYAHWG-PRWAFSLVCGIIVLTITLLGVVYKR 456
Cdd:COG2223   311 GGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTLLLYRR 385
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 73-184 2.59e-03

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 39.89  E-value: 2.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942  73 TSFL-GWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAANCLYAYlhipaSHNKYYMLVARGLLGIGAGNvAV 151
Cdd:cd17472    30 TPTLiGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAY-----ATSIYGLILGRALQGSGAIS-SV 103

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1706865942 152 VRSYTAGATSLQERTSSMA----NISMCQALGFILGP 184
Cdd:cd17472   104 VMALLADLTREENRTKAMAligaSIGIAFAISMVLGP 140
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 35-152 3.37e-03

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 39.51  E-value: 3.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942  35 RWRSIRILYLTMFLSSVGFSVVMMSIWPYLQKIDPTADTSFlgWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILIS 114
Cdd:cd17332   219 KNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELV--LLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLA 296

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1706865942 115 VAANCLYAYLHipaSHNKYYMLVARGLLGIGAGNVAVV 152
Cdd:cd17332   297 ILGLLLLFFLP---PGNLVLILVLAVLAGIGYGGANLL 331
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 40-183 9.11e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 38.35  E-value: 9.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942  40 RILYLTMFLSSVGFSVVMMSIW-PYLQKIDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAAN 118
Cdd:cd17316   178 RTLLLILLWFFISFGYYGLTTFlPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILA 257

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1706865942 119 CLYAYLHipaSHNKYYMLVARGLLGI-GAGNVAVVRSYTAGATSLQERTSSMAnisMCQALGFILG 183
Cdd:cd17316   258 LPLFYLL---SGSPTLLLLLLFILSFfVGGVWGALYAYLAELFPTEVRATGVG---LSYNLGRLGG 317
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 11-166 9.21e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 38.37  E-value: 9.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942  11 EPLLGDTPGSREWDILETEEHYKSRWRSIRILYLTMFLSSVgFSVVMMSIWPYLQKIDPTADTSFLGWVIASYSLGQMVA 90
Cdd:cd06173   182 PPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFAL-LGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLG 260

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1706865942  91 SPIFGLWSNYRPRKEPLIVSILISVAanclyAYLHIPASHNKYYMLVARGLLGIGAGNVAVVRSytagaTSLQERT 166
Cdd:cd06173   261 ALLLGRLSKRRRRGRLLLIGALLLGL-----ALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLN-----TLLQLRV 326
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 62-183 9.85e-03

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 37.97  E-value: 9.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865942  62 PYLQKIDptADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVS-ILISVAANclyayLHIPASHNKYYMLVARG 140
Cdd:cd17490    21 PYAESLG--ASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFIIIgLLFTVLAS-----LIMILFPSPWGLLIARF 93

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1706865942 141 LLGIGAGNVAVVRSYTAGATSLQERTSSMANISMCQALGFILG 183
Cdd:cd17490    94 LSGIAAATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIA 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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