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Conserved domains on  [gi|1706865886|ref|NP_001358521|]
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major facilitator superfamily domain-containing protein 8 isoform 6 [Homo sapiens]

Protein Classification

MFSD8-like MFS transporter( domain architecture ID 13023588)

MFSD8-like major facilitator superfamily (MFS) transporter similar to MFS domain-containing protein 8, also called ceroid-lipofuscinosis neuronal protein 7 (CLN7), a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085|GO:0016020
PubMed:  26098515|26758938|26234418
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
 39-509 1.68e-154

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 445.50  E-value: 1.68e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886  39 IRILYLTMFLSSVGFSVVMMSIWPYLQKIDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRP-RKEPLIVSILISVAA 117
Cdd:cd17326     1 IYVMYLTMFLSSLQFSIVLTSIWPYLQKIDPTATASFFGWVVAAYSLGQLVFSPVFGYWSNKTSsVKEPLIVSILIAIVG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 118 NCLYAYLHIPASHNKYYMLVARGLLGIGAGNVAVVRSYTAGATSLQERTSSMANISMCQALGFILGPgrFFQTCFTFLGE 197
Cdd:cd17326    81 NILYALAEYFPSNRKYVMLVARFLIGVGAGNVAVLRAYVAAASTLKDRTRAMAVISAAQALGFIVGP--ALQAAFTPIGY 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 198 KGVTWDvIKLQINMYTTPVLLSAFLGILNIILILAILREhrvddsgrqcksinfeeastdeaqvpqgnidqvavVAINVL 277
Cdd:cd17326   159 PGYVIG-IKLRFNMYTAPAWLMAILGIINIILILFFFKE-----------------------------------VVCIFL 202

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 278 FFVTLFIFALFETIITPLTMDMYAWTQEQAVLYNGIILAALGVEAVVIFLGVKLLSKK-IGERAILLGGLIVVWVGFFIL 356
Cdd:cd17326   203 FFVVLFIFANLETIGTPLTMDMYGWTREEAVLYNGIILAVSGVLSVLVFLLFKFLSLGlIDERKILLGGLILFFLGFVVT 282

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 357 LPWGnqfpkiqwedlhnnsipnttfgeiiiglwkspmeddnerptgcsieqawclytpvihlaqfLTSAVLIGLGYPVCN 436
Cdd:cd17326   283 LPWG-------------------------------------------------------------ITGVILFGLGYPIGN 301

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1706865886 437 LMSYTLYSKILGPKPQGVYMGWLTASGSGARILGPMFISQVYAHWGPRWAFSLVCGIIVLTITLLGVVYKRLI 509
Cdd:cd17326   302 VMLYTLYSKILGPKPQGTMQGVLTASGSLARTLGPIFVTAIYTHFGPRWTWIITLGLLLLAIILLIVFYKRLV 374
 
Name Accession Description Interval E-value
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
 39-509 1.68e-154

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 445.50  E-value: 1.68e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886  39 IRILYLTMFLSSVGFSVVMMSIWPYLQKIDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRP-RKEPLIVSILISVAA 117
Cdd:cd17326     1 IYVMYLTMFLSSLQFSIVLTSIWPYLQKIDPTATASFFGWVVAAYSLGQLVFSPVFGYWSNKTSsVKEPLIVSILIAIVG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 118 NCLYAYLHIPASHNKYYMLVARGLLGIGAGNVAVVRSYTAGATSLQERTSSMANISMCQALGFILGPgrFFQTCFTFLGE 197
Cdd:cd17326    81 NILYALAEYFPSNRKYVMLVARFLIGVGAGNVAVLRAYVAAASTLKDRTRAMAVISAAQALGFIVGP--ALQAAFTPIGY 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 198 KGVTWDvIKLQINMYTTPVLLSAFLGILNIILILAILREhrvddsgrqcksinfeeastdeaqvpqgnidqvavVAINVL 277
Cdd:cd17326   159 PGYVIG-IKLRFNMYTAPAWLMAILGIINIILILFFFKE-----------------------------------VVCIFL 202

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 278 FFVTLFIFALFETIITPLTMDMYAWTQEQAVLYNGIILAALGVEAVVIFLGVKLLSKK-IGERAILLGGLIVVWVGFFIL 356
Cdd:cd17326   203 FFVVLFIFANLETIGTPLTMDMYGWTREEAVLYNGIILAVSGVLSVLVFLLFKFLSLGlIDERKILLGGLILFFLGFVVT 282

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 357 LPWGnqfpkiqwedlhnnsipnttfgeiiiglwkspmeddnerptgcsieqawclytpvihlaqfLTSAVLIGLGYPVCN 436
Cdd:cd17326   283 LPWG-------------------------------------------------------------ITGVILFGLGYPIGN 301

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1706865886 437 LMSYTLYSKILGPKPQGVYMGWLTASGSGARILGPMFISQVYAHWGPRWAFSLVCGIIVLTITLLGVVYKRLI 509
Cdd:cd17326   302 VMLYTLYSKILGPKPQGTMQGVLTASGSLARTLGPIFVTAIYTHFGPRWTWIITLGLLLLAIILLIVFYKRLV 374
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
33-361 1.41e-18

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 86.95  E-value: 1.41e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886  33 KSRWRSIRILYLTMFLSSVGFSVVMmSIWPYLQKiDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSIL 112
Cdd:COG2814     6 RRRWLALLALALGAFLSGLGIGIVL-PALPLIAA-DLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 113 ISVAANCLYAylhipASHNKYYMLVARGLLGIGAG-NVAVVRSYTAGATSLQERTSSMANISMCQALGFILGPgrffqtc 191
Cdd:COG2814    84 LFALGSLLCA-----LAPSLWLLLAARFLQGLGAGaLFPAALALIADLVPPERRGRALGLLGAGLGLGPALGP------- 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 192 fTFLGEKGVTWDviklqinmYTTPVLLSAFLGILNIILILAILREHRVDDSGRQCKSInfeeastdeaqvpQGNIDQVAV 271
Cdd:COG2814   152 -LLGGLLADLFG--------WRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSL-------------RELLRRPRL 209

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 272 VAINVLFFVTLFIFALFETIITPLTMDMYAWTQEQAvlynGIILAALGVEAVVIFLGVKLLSKKIGERAILLGGLIVVWV 351
Cdd:COG2814   210 LLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAA----GLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLAL 285

                         330
                  ....*....|
gi 1706865886 352 GFFILLPWGN 361
Cdd:COG2814   286 GLLLLALAGS 295
MFS_1 pfam07690
Major Facilitator Superfamily;
42-471 1.12e-11

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 66.29  E-value: 1.12e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886  42 LYLTMFLSSVGFSVVMMSIWPYLQKiDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAANCLY 121
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAE-DLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 122 AYlhipaSHNKYYMLVARGLLGIGAGNV-AVVRSYTAGATSLQERTSSMANISMCQALGFILGPGrFFQTCFTFLGekgv 200
Cdd:pfam07690  80 LF-----ASSLWLLLVLRVLQGLGAGALfPAALALIADWFPPEERGRALGLVSAGFGLGAALGPL-LGGLLASLFG---- 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 201 twdviklqinmYTTPVLLSAFLGILNIILILAILREHRVddsgrqcKSINFEEASTDEAQVPQGNIDQVAVVAINVLFFV 280
Cdd:pfam07690 150 -----------WRAAFLILAILSLLAAVLLLLPRPPPES-------KRPKPAEEARLSLIVAWKALLRDPVLWLLLALLL 211

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 281 TLFIFALFETIItPLTMDMYAWTQEQAVLYngIILAALGVEAVVIFLGVklLSKKIGERAILLGGLIVVWVGFFILLpwg 360
Cdd:pfam07690 212 FGFAFFGLLTYL-PLYQEVLGLSALLAGLL--LGLGGLLGAIGRLLLGR--LSDRLGRRRRLLLALLLLILAALGLL--- 283

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 361 nqfpkiqwedlhnnsipnttfgeiiiglwkspmeddnerptgcsieqawcLYTPVIHLAQFLTSAVLIGLGYPVCNLMSY 440
Cdd:pfam07690 284 --------------------------------------------------LLSLTLSSLWLLLALLLLGFGFGLVFPALN 313

                         410       420       430
                  ....*....|....*....|....*....|.
gi 1706865886 441 TLYSKILGPKPQGVYMGWLTASGSGARILGP 471
Cdd:pfam07690 314 ALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
 
Name Accession Description Interval E-value
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
 39-509 1.68e-154

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 445.50  E-value: 1.68e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886  39 IRILYLTMFLSSVGFSVVMMSIWPYLQKIDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRP-RKEPLIVSILISVAA 117
Cdd:cd17326     1 IYVMYLTMFLSSLQFSIVLTSIWPYLQKIDPTATASFFGWVVAAYSLGQLVFSPVFGYWSNKTSsVKEPLIVSILIAIVG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 118 NCLYAYLHIPASHNKYYMLVARGLLGIGAGNVAVVRSYTAGATSLQERTSSMANISMCQALGFILGPgrFFQTCFTFLGE 197
Cdd:cd17326    81 NILYALAEYFPSNRKYVMLVARFLIGVGAGNVAVLRAYVAAASTLKDRTRAMAVISAAQALGFIVGP--ALQAAFTPIGY 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 198 KGVTWDvIKLQINMYTTPVLLSAFLGILNIILILAILREhrvddsgrqcksinfeeastdeaqvpqgnidqvavVAINVL 277
Cdd:cd17326   159 PGYVIG-IKLRFNMYTAPAWLMAILGIINIILILFFFKE-----------------------------------VVCIFL 202

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 278 FFVTLFIFALFETIITPLTMDMYAWTQEQAVLYNGIILAALGVEAVVIFLGVKLLSKK-IGERAILLGGLIVVWVGFFIL 356
Cdd:cd17326   203 FFVVLFIFANLETIGTPLTMDMYGWTREEAVLYNGIILAVSGVLSVLVFLLFKFLSLGlIDERKILLGGLILFFLGFVVT 282

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 357 LPWGnqfpkiqwedlhnnsipnttfgeiiiglwkspmeddnerptgcsieqawclytpvihlaqfLTSAVLIGLGYPVCN 436
Cdd:cd17326   283 LPWG-------------------------------------------------------------ITGVILFGLGYPIGN 301

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1706865886 437 LMSYTLYSKILGPKPQGVYMGWLTASGSGARILGPMFISQVYAHWGPRWAFSLVCGIIVLTITLLGVVYKRLI 509
Cdd:cd17326   302 VMLYTLYSKILGPKPQGTMQGVLTASGSLARTLGPIFVTAIYTHFGPRWTWIITLGLLLLAIILLIVFYKRLV 374
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 42-503 2.42e-57

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 194.33  E-value: 2.42e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886  42 LYLTMFLSSVGFSVVMMSIWPYLQKI-DPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAANCL 120
Cdd:cd17330     1 LFLVVFLDALGFGIVFPVLPFYVREFnKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 121 YAYlhipaSHNKYYMLVARGLLGIGAGNVAVVRSYTAGATSLQERTSSMANISMCQALGFILGP--GRFFqtcftflgek 198
Cdd:cd17330    81 LGL-----SRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPalGGFL---------- 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 199 gvtwdvikLQINMYTTPVLLSAFLGILNIILILailrehrvddsgrqcksinfeeastdeaqvpqgnidqVAVVAINVLF 278
Cdd:cd17330   146 --------STPYGYALPFLVAAALALLNLVLVL-------------------------------------FFLPPLRRLL 180

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 279 FVTLFI---FALFETIITPLTMDMYAWTQEQAvlynGIILAALGVEAVVIFLGV-KLLSKKIGERAILLGGLIVVWVGFF 354
Cdd:cd17330   181 LVYFLIalaFAGLESVFSLFLKDRFGFSPSQI----GLLLALVGIAGILAQLLLiPRLAKRLGERKLLRLGLLLAIIGLL 256

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 355 iLLPWGNQFPkiqwedlhnnsipnttfgeiiiglwkspmeddnerptgcsieqawclytpvihlaQFLTSAVLIGLGYPV 434
Cdd:cd17330   257 -LLPFASSVP-------------------------------------------------------LLVLAAAILAFGTGI 280

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1706865886 435 CNLMSYTLYSKILGPKPQGVYMGWLTASGSGARILGPMFISQVYAHWGPRWAFSLVCGIIVLTITLLGV 503
Cdd:cd17330   281 VFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 42-506 3.44e-21

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 95.34  E-value: 3.44e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886  42 LYLTMFLSSVGFSVVMMSIWPYLQKIDptADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAANCLY 121
Cdd:cd17325     1 LSLALFLDMLGYGIIIPILPLYAESLG--ASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLF 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 122 AYLHIPashnkYYMLVARGLLGIGAGNVAVVR-SYTAGATSLQERTSSMANISMCQALGFILGPgrffqtcftFLGekGV 200
Cdd:cd17325    79 AFATSY-----WQLLLARFLQGLASAAVWPAAmALIADIAPPEERGRAMGIFSSAIGLGFLIGP---------LLG--GL 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 201 TWDVIklqinMYTTPVLLSAFLGILNIILILAILREHRVDDSGRQCKSINFEEASTDEAQVPqgnidqvAVVAINVLFFV 280
Cdd:cd17325   143 LADAL-----GYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDR-------RLLALFLAIFV 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 281 TLFIFALFETIITPLTMDMYAWTQEQAvlynGIILAALGVEAVVIFLGVKLLSKKIGERAILLGGLIVVwVGFFILLPWG 360
Cdd:cd17325   211 LAFAFGALEPFLPLYAAELGGLSPAQI----GLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLS-AVALLLLPLA 285

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 361 NQFPkiqwedlhnnsipnttfgeiiiglwkspmeddnerptgcsieqawclytpvihlaQFLTSAVLIGLGYPVCNLMSY 440
Cdd:cd17325   286 TSFW-------------------------------------------------------LLLLLLALLGLGLGLVFPATL 310

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1706865886 441 TLYSKILGPKPQGVYMGWLTASGSGARILGPMFISQVYAHWGPRWAFsLVCGIIVLTITLLGVVYK 506
Cdd:cd17325   311 ALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPF-LAAAALLLLAAVLFLLLR 375
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
33-361 1.41e-18

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 86.95  E-value: 1.41e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886  33 KSRWRSIRILYLTMFLSSVGFSVVMmSIWPYLQKiDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSIL 112
Cdd:COG2814     6 RRRWLALLALALGAFLSGLGIGIVL-PALPLIAA-DLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 113 ISVAANCLYAylhipASHNKYYMLVARGLLGIGAG-NVAVVRSYTAGATSLQERTSSMANISMCQALGFILGPgrffqtc 191
Cdd:COG2814    84 LFALGSLLCA-----LAPSLWLLLAARFLQGLGAGaLFPAALALIADLVPPERRGRALGLLGAGLGLGPALGP------- 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 192 fTFLGEKGVTWDviklqinmYTTPVLLSAFLGILNIILILAILREHRVDDSGRQCKSInfeeastdeaqvpQGNIDQVAV 271
Cdd:COG2814   152 -LLGGLLADLFG--------WRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSL-------------RELLRRPRL 209

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 272 VAINVLFFVTLFIFALFETIITPLTMDMYAWTQEQAvlynGIILAALGVEAVVIFLGVKLLSKKIGERAILLGGLIVVWV 351
Cdd:COG2814   210 LLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAA----GLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLAL 285

                         330
                  ....*....|
gi 1706865886 352 GFFILLPWGN 361
Cdd:COG2814   286 GLLLLALAGS 295
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 42-193 2.36e-12

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 68.41  E-value: 2.36e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886  42 LYLTMFLSSVGFSVVMMSIWPYLQKIDptADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILIsvaanCLY 121
Cdd:cd17390     1 LYLVGFLDLFGVSMILPLLSTHIRSLG--ASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLL-----TAL 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 122 AYLHIPASHNKYYMLVARGLLGIGAGNVAVVRSYTAGATSLQERTSSMANISMCQALGFILGP----------GRFFQTC 191
Cdd:cd17390    74 GYVLLGFSTSLALLFLSRIPLGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPvvgghlaetdGGFYYVA 153


                  ..
gi 1706865886 192 FT 193
Cdd:cd17390   154 LL 155
MFS_1 pfam07690
Major Facilitator Superfamily;
42-471 1.12e-11

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 66.29  E-value: 1.12e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886  42 LYLTMFLSSVGFSVVMMSIWPYLQKiDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAANCLY 121
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAE-DLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 122 AYlhipaSHNKYYMLVARGLLGIGAGNV-AVVRSYTAGATSLQERTSSMANISMCQALGFILGPGrFFQTCFTFLGekgv 200
Cdd:pfam07690  80 LF-----ASSLWLLLVLRVLQGLGAGALfPAALALIADWFPPEERGRALGLVSAGFGLGAALGPL-LGGLLASLFG---- 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 201 twdviklqinmYTTPVLLSAFLGILNIILILAILREHRVddsgrqcKSINFEEASTDEAQVPQGNIDQVAVVAINVLFFV 280
Cdd:pfam07690 150 -----------WRAAFLILAILSLLAAVLLLLPRPPPES-------KRPKPAEEARLSLIVAWKALLRDPVLWLLLALLL 211

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 281 TLFIFALFETIItPLTMDMYAWTQEQAVLYngIILAALGVEAVVIFLGVklLSKKIGERAILLGGLIVVWVGFFILLpwg 360
Cdd:pfam07690 212 FGFAFFGLLTYL-PLYQEVLGLSALLAGLL--LGLGGLLGAIGRLLLGR--LSDRLGRRRRLLLALLLLILAALGLL--- 283

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 361 nqfpkiqwedlhnnsipnttfgeiiiglwkspmeddnerptgcsieqawcLYTPVIHLAQFLTSAVLIGLGYPVCNLMSY 440
Cdd:pfam07690 284 --------------------------------------------------LLSLTLSSLWLLLALLLLGFGFGLVFPALN 313

                         410       420       430
                  ....*....|....*....|....*....|.
gi 1706865886 441 TLYSKILGPKPQGVYMGWLTASGSGARILGP 471
Cdd:pfam07690 314 ALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 35-184 5.22e-10

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 61.05  E-value: 5.22e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886  35 RWRSIRILYLTMFLSSVGFSVVMMSIWPYLQKIDpTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILIS 114
Cdd:cd17325   197 RDRRLLALFLAIFVLAFAFGALEPFLPLYAAELG-GLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLS 275

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1706865886 115 VAanclyAYLHIPASHNKYYMLVARGLLGIGAGNV-AVVRSYTAGATSLQERTSSMANISMCQALGFILGP 184
Cdd:cd17325   276 AV-----ALLLLPLATSFWLLLLLLALLGLGLGLVfPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGP 341
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 39-501 2.11e-09

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 59.19  E-value: 2.11e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886  39 IRILYLTMFLSSVGFSVvMMSIWPYL--QKIDPTAD-TSFLGWVIASYSLGQMVASPIFGLWSNYRPRKePLIVSILISV 115
Cdd:cd17388     1 LIFILVTVLLDAMGIGL-IMPVLPTLlrEFVGDSADaATHYGVLLALYALMQFIFAPILGALSDRFGRR-PVLLLSLAGA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 116 AANclyaYLHIPASHNKYYMLVARGLLGIGAGNVAVVRSYTAGATSLQERTSSMANISMCQALGFILGP---Grffqtcf 192
Cdd:cd17388    79 ALD----YLLMAFAPTLWWLYLGRIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPalgG------- 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 193 tFLGEKGVtwdviklqinmyTTPVLLSAFLGILNIILILAILREHRVDDSGRqcksinfeeASTDEAQVPQGNIDQVAVV 272
Cdd:cd17388   148 -LLGEISP------------RAPFLVAAGLNGLNFLLGLFVLPESLPPERRR---------AFRWRRANPFGSLRWLTGF 205

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 273 AINVLFFVTLFIFALFETIITPL----TMDMYAWTQEQavlyNGIILAALGVEAVVI-FLGVKLLSKKIGERAILLGGLI 347
Cdd:cd17388   206 PGLLGLLAVFFLIQLIGQVPATTwvlfTEDRFDWSPTM----VGLSLAVFGLLHALFqAFVTGPIAKRLGEKRAILLGLA 281

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 348 VVWVGFFILlpwgnqfpkiqwedlhnnsipnttfgeiiiglwkspmeddnerptgCSIEQAWCLYTPVIHLAqfltsavL 427
Cdd:cd17388   282 ADALGFLLL----------------------------------------------AFATQGWMVFPILILLA-------L 308

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1706865886 428 IGLGYPVCNlmsyTLYSKILGPKPQGVYMGWLTASGSGARILGPMFISQVYA----HWgPRWAFSLVCGIIVLTITLL 501
Cdd:cd17388   309 GGIAGPALQ----GLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGIFAaspaTW-PGLAWIIGAALYLICLVLA 381
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 33-184 5.66e-09

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 57.51  E-value: 5.66e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886  33 KSRWRSIRILYLTMFLSSVGFSVVMMSIwPYLQKiDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSIL 112
Cdd:COG0477    10 RRRRRALLALALGTFLEGLDFTIVNVAL-PSIAA-DLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLL 87

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1706865886 113 ISVAANCLYAYLHIPAShnkyyMLVARGLLGIGAG-NVAVVRSYTAGATSLQERTSSMANISMCQALGFILGP 184
Cdd:COG0477    88 LFGLASLLCGLAPSPEL-----LIAARALQGIGAGgLMPGALALIAELFPARERGRALGLWGAAIGLGLALGP 155
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 44-501 2.92e-08

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 55.90  E-value: 2.92e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886  44 LTMFLSSVGFSVVMMS-IWPYLQKiDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAANCLYA 122
Cdd:cd06174     1 LLLGFFLTGLARGLISpLLPALLQ-SFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 123 YLHIPAShnkyyMLVARGLLGIGAGNVAVVR-SYTAGATSLQERTSSMANISMCQALGFILGPgrffqtcftFLGEKGVT 201
Cdd:cd06174    80 FAPSFWL-----LLLGRFLLGLGSGLIDPAVlALIADLFPERERGRALGLLQAFGSVGGILGP---------LLGGILAS 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 202 WDVI--KLQINMYTTPVLLSAFLGILNIililailrehrvddsgrqcKSINFEEASTDEAQVPQGNIDQVAVVAINVLFF 279
Cdd:cd06174   146 SLGFgwRAVFLIAAALALLAAILLLLVV-------------------PDPPESARAKNEEASSKSVLKLLKRVLKNPGLW 206

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 280 VTLFIFALFETIITPLTMDMYAWTQEQAVL----YNGIILAALGVEAVVIFLGVKLLSKKIGERAILLGGLIVVWVGFFI 355
Cdd:cd06174   207 LLLLAIFLVNLAYYSFSTLLPLFLLDLGGLsvavAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLAL 286

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 356 LLPWGnqfpkiqwedlhnnsipnttfgeiiiglwkspmeddnerptgcsieqawclytpviHLAQFLTSAVLIGLGYPVC 435
Cdd:cd06174   287 LLLAP--------------------------------------------------------SLLLLLLLLLLLGFGLGGL 310

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1706865886 436 NLMSYTLYSKILGPKPQGVYMGWLTASGSGARILGPMFISQVYA-HWGPRWAFSLVCGIIVLTITLL 501
Cdd:cd06174   311 LPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAaTFGLTGAFLVLAVLLLLAAILL 377
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 59-205 1.29e-07

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 53.82  E-value: 1.29e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886  59 SIWPYLQKIDPTA--DTSFLGWVIAS-YSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAANCLYAylhipASHNKYYM 135
Cdd:cd17389    46 DWFRDAIGAPDERryNSVLFGGLIGSlFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAISYALWA-----VSRSFTIF 120

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1706865886 136 LVARGLLGIGAGNVAVVRSYTAGATSLQERTSSMANISMCQALGFILGP--GRFFQtcfTFLGEKGVTWDVI 205
Cdd:cd17389   121 LLSRIVGGISKGNVSLSTAIVADVTSPKKRSKGMALIGVAFSLGFIIGPmiGAYFA---SFTRSLGEVFFSM 189
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 38-356 3.42e-07

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 52.61  E-value: 3.42e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886  38 SIRILYLTMFLSSVGFSVvMMSIWPYL-QKIDptADTSFLGWVIASYSLGQMVASPIFGLWSN-YRPRKEpLIVSILisv 115
Cdd:cd17331     1 VLLIVHLNIVLYATCYWL-QQPVLPYLtKKLG--VDSVVFGYLQTTFSVLQLVGGPLFGRFGDlFGPRAA-LVLSFL--- 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 116 AANCLYAYLhipASHNKYYMLVARGLLGIGAGNVAVVRSYTAGATSLQERTSSMANISMCQALGFILGPgrffqtcftFL 195
Cdd:cd17331    74 SSALSYLLL---AFASSVPMLFLSRLPSVFMHAMQAAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGS---------FL 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 196 GekGVTWDVIKLQINMYTTPV--LLSAFLGILNIILILAILREHRVDDSGRQCKSINFEEAStdeaqvpqgNIDQVAVVA 273
Cdd:cd17331   142 G--GLLTKKFGEQAAALVAAVgsLLSIVLVILLIPSNTKSKREKEAKESASPPSVFNLKEIL---------RLLRLPGVA 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 274 INVLF-FVTLFIFALFETIITPLTMDMYAWTQEQavlyNGIILAALGV-EAVVIFLGVKLLSKKIGERAILLGGLIVVWV 351
Cdd:cd17331   211 FLLLVkLLSGLPIGMFQSMFSLVAMDFFGLTPEE----NGYLMSYAGVlGMVVQGLLVGPLTKRFGERSLLKLSVALLAI 286


                  ....*
gi 1706865886 352 GFFIL 356
Cdd:cd17331   287 GYLLL 291
Sugar_tr pfam00083
Sugar (and other) transporter;
71-147 1.56e-06

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 50.73  E-value: 1.56e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1706865886  71 ADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAANCLyayLHIPASHNKYYML-VARGLLGIGAG 147
Cdd:pfam00083  43 ALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVL---QGAAKGKWSVYQLiVGRVLVGIGVG 117
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
33-508 6.64e-06

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 48.33  E-value: 6.64e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886  33 KSRWRSIRILYLTMFLSSVGFSVVMMsIWPYLQK---IDPTAdtsfLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIV 109
Cdd:COG2271     6 RYRWRILALLFLAYFLNYLDRSNLSV-AAPPLQAdlgLSAAQ----LGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 110 SILISVAANCLYAYlhipaSHNKYYMLVARGLLGIG-AGNVAVVRSYTAGATSLQERTSSMANISMCQALGFILGPGrFF 188
Cdd:COG2271    81 GLLLWGLATLLFGF-----ATSFWQLLLLRFLLGLGeAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPP-LL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 189 QTCFTFLGEKGVTWdviklqinMYTTPVLLSAFlgilniililailrehrvddsgrqcksinfeeastdeaqvpqgnidq 268
Cdd:COG2271   155 GWLLAAFGWRAAFL--------ILGLPGLLLAL----------------------------------------------- 179

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 269 VAVVAINVLFFVTLFIFALFETIITPLTMDMYAWTQEQAVLYNGIILAAlgveAVVIFLGVKLLSKKIGERaillgGLIV 348
Cdd:COG2271   180 LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLA----GIVGSLLGGWLSDRLGRR-----RKLV 250

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 349 VWVGFFILLPwgnqfpkiqwedlhnnsipnttfgeiiiglwkspmeddnerptgcsieqAWCLYTPVIHLAQFLTSAVLI 428
Cdd:COG2271   251 LAIGLLLAAL-------------------------------------------------ALLLLALLPSPALAIALLFLA 281

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 429 GLGYPVCNLMSYTLYSKILGPKPQGVYMGWLTASGSGARILGPMFISQVYAHWGPRWAFSLVCGIIVLTITLLGVVYKRL 508
Cdd:COG2271   282 GFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRET 361
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 36-184 9.73e-06

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 47.95  E-value: 9.73e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886  36 WRSIRILYLTMFLSSVGFSVVMMSIWPYLQKIDpTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPrKEPLIVSILISV 115
Cdd:cd17473   196 WKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERG-GGSAALIGLALAIASLAGAIGALLFGRLKRRLG-KRRLLAIGFALM 273

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 116 AAnclyAYLHIPASHNKYYMLVARGLLGIGAG-NVAVVRSYTAGATSLQERTSSMANISMCQALGFILGP 184
Cdd:cd17473   274 AL----GFLLLALASGLWVVLLGAILAGLGFGlLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSP 339
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 77-183 1.75e-05

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 47.16  E-value: 1.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886  77 GWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAANCLYAylhipASHNKYYMLVARGLLGIGAGNV-AVVRSY 155
Cdd:cd17324    37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAA-----LAPSFALLLLARALAGLAHGGFwAIAAAY 111

                          90       100
                  ....*....|....*....|....*...
gi 1706865886 156 TAGATSLQERTSSMANISMCQALGFILG 183
Cdd:cd17324   112 AADLVPPEKRGRAIGLVFSGLTLGLVLG 139
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 39-195 3.98e-05

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 46.07  E-value: 3.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886  39 IRILYLTMFLSSVGFSVVM--MSIWPYLQKIDPTadtSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVA 116
Cdd:cd17329     1 LWVLLIGSFLNRLGFFMVWpfMAIYLHQQLGLSA---SIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRAL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 117 ANCLYAYLHIPAshnkyymLVARGLLGIGAGN---VAVVRSYTAGATSLQERTSSMANISMCQALGFILGP---GRFFQT 190
Cdd:cd17329    78 GFALLGFAHSPW-------LFAIALVLTGFGGglfEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPllgGLLLLY 150


                  ....*
gi 1706865886 191 CFTFL 195
Cdd:cd17329   151 SFRLL 155
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
33-185 7.21e-05

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 45.23  E-value: 7.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886  33 KSRWRSIRILYLTMFLSSVGFSVVMmSIWPYLQKIDpTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSIL 112
Cdd:COG0738     4 KNYRRALIAIYLLFFLWGFATALWG-PLIPALKDAF-GLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLL 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1706865886 113 ISVAANCLYAYlhipaSHNKYYMLVARGLLGIGAG--NVAVvrsyTAGATSLQERTSSmANISMCQA---LGFILGPG 185
Cdd:COG0738    82 LMALGLLLFAL-----APSYPLLLLALFLLGLGLGllDVAA----NPYVAALGPETAA-SRLNLLHAffsLGALLGPL 149
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
417-501 9.96e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 44.58  E-value: 9.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 417 HLAQFLTSAVLIGLGYPVCNLMSYTLYSKILGPKPQGVYMGWLTASGSGARILGPMFISQVYAHWGPRWAFsLVCGIIVL 496
Cdd:COG2814    97 SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVF-LVNAVLAL 175


                  ....*
gi 1706865886 497 TITLL 501
Cdd:COG2814   176 LALLL 180
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 30-184 1.36e-04

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 44.34  E-value: 1.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886  30 EHYKSRWRSIRILYLTMFLSSVGFSVV-MMSIWPYLQKIDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLI 108
Cdd:cd06174   194 KLLKRVLKNPGLWLLLLAIFLVNLAYYsFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLL 273

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1706865886 109 VSILISVAANCLYAYLHIPashnKYYMLVARGLLGIGAGNVAVVR-SYTAGATSLQERTSSMANISMCQALGFILGP 184
Cdd:cd06174   274 LIGLLLMALGLALLLLAPS----LLLLLLLLLLLGFGLGGLLPLSfALIAELFPPEIRGTAFGLLNTFGFLGGAIGP 346
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 42-185 1.87e-04

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 43.74  E-value: 1.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886  42 LYLTMFLSSVGFSVVMMSIWPYLQKIDPTADTSflGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAANCLY 121
Cdd:cd17489     1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVA--GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLY 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1706865886 122 AYLHIPAShnkyyMLVARGLLGIGAGNVAVVRS-YTAGATSLQERTSSMANISMCQALGFILGPG 185
Cdd:cd17489    79 LLATSVAL-----LLVLRLIHGIGWGAFTTAAAtLVADIIPPSRRGEGIGYYGLATTLAMALGPA 138
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 41-356 2.24e-04

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 43.72  E-value: 2.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886  41 ILYLTMFLSSVGFSVVMMSIwPYLQKIDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAANCL 120
Cdd:cd17473     3 TLLLASTLTVMAGAAIAPAL-PAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 121 YAYLhipashNKYY-MLVARGLLGIGAGNVAVVrsytagATSL-------QERTSSMANISMCQALG---FILGPGrffq 189
Cdd:cd17473    82 GLFL------DSLYaLLASRALLGIGVAGIMTL------ATALigdyfegEERAKMLGLQSAAMSLGgvvFLLLGG---- 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 190 tcftFLGEKGvtWDVIKLqinMYTTPVLLSAFLGILNiililailrEHRVDDSGRQCKSINFEEASTDeaqvpqgnidqv 269
Cdd:cd17473   146 ----ALAEIG--WRAPFL---VYLLALPVLILVLLFL---------PEPARKSKSAASPGAATAAALP------------ 195

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 270 aVVAINVLFFVTLFIFALFETIITPLTMDMYAwTQEQAVLYNGIILAALGVEAVVIFLGVKLLSKKIGERAILLGGLIVV 349
Cdd:cd17473   196 -WKRVLPIYFLAFLAMLLFYVIPIQLPFLLQE-RGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALM 273


                  ....*..
gi 1706865886 350 WVGFFIL 356
Cdd:cd17473   274 ALGFLLL 280
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 42-184 3.07e-04

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 42.94  E-value: 3.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886  42 LYLTMFLSSVGFSVVMMSIwpylqkidPT-----ADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVA 116
Cdd:cd17502     1 LMLALFLAALDQTIVATAL--------PTivaefGGLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFEL 72

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 117 ANCLYAylhipASHNKYYMLVARGLLGIGAGNVAVVrSYTAGA--TSLQERTSSMANISMCQALGFILGP 184
Cdd:cd17502    73 GSLLCG-----LAPNMTMLIVGRAIQGIGGGGLMSL-AFIIIAdlVPPRERGKYQGYIGAVFGIASVAGP 136
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 42-184 5.39e-04

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 42.15  E-value: 5.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886  42 LYLTMFLSSVGFSVVM--MSIW--PYLQkidptADTSFLGWVIASYSLGQMVASPIFGLWSNYR-PRKEPLIVSILISVA 116
Cdd:cd17471     1 LLLATLLTGLAGAFVLpyLSLFltEELG-----ASPLQIGIFMTLSALSGIVVSQWLGRLSDRGgDRKPLILLALLAGAL 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1706865886 117 ANCLYAYLHIpashnkYYMLVARGLLGIGAGNVAV------VRSYtAGATSLQERTSSMANISMCQALGFILGP 184
Cdd:cd17471    76 GYLLFAFLRN------YWVLLLVGVVLLSLGAAAFpqlfalAREY-ADRSSGRDATLFNSVLRAAFSLAWVIGP 142
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 411-504 6.85e-04

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 41.81  E-value: 6.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 411 LYTPVIHLAQFLTSAVLIGLGYPVCNLMSYTLYSKILGPKPQGVYMGWLTASGSGARILGPMFISQVYAHWGPRWAFSLV 490
Cdd:cd17489    77 LYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVA 156

                          90
                  ....*....|....
gi 1706865886 491 CGIIVLTITLLGVV 504
Cdd:cd17489   157 AVLALLALLLVFLV 170
MFS_1 pfam07690
Major Facilitator Superfamily;
37-184 8.02e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 41.63  E-value: 8.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886  37 RSIRILYLTMFLSSVGFSVVMMSIWPYLQKIDptADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVA 116
Cdd:pfam07690 200 DPVLWLLLALLLFGFAFFGLLTYLPLYQEVLG--LSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLIL 277

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1706865886 117 ANCLYAYLHIPASHNKYYMLVArgLLGIGAG-NVAVVRSYTAGATSLQERTSSMANISMCQALGFILGP 184
Cdd:pfam07690 278 AALGLLLLSLTLSSLWLLLALL--LLGFGFGlVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 37-189 1.21e-03

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 41.38  E-value: 1.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886  37 RSIRILYLTMFLSSVGFSVVMMSIWPYLQKIdPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVA 116
Cdd:cd17324   198 PRLRLAYLITFLLFGGFFALYTYLAPFLTDV-PGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAA 276

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1706865886 117 ANCLYAYLHIPAShnkyyMLVARGLLGIGAGNVAVVRSYTAGATSLQERTSSMANISMCQALGFILGP---GRFFQ 189
Cdd:cd17324   277 LLLLTLLGPSPLL-----LLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYNLGGALGAalgGLVLD 347
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 37-162 1.22e-03

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 41.02  E-value: 1.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886  37 RSIRILYLTMFLSSVGFSVVMMSIWPYLQkiDPTADTSFL-----GWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSI 111
Cdd:cd17504   177 RNVLLANITALLAGFGMFMVFQLLPQLLQ--LPTPTGFGLgiteaGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGL 254

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1706865886 112 LISVAANCLYAYLHIPASHnkyyMLVARGLLGIGAGN----------VAVVRSYTAGATSL 162
Cdd:cd17504   255 VISAVGLLLLALLHSSLWA----LVVALLLIGIGLGLafaslpnivvESVPPDRTGIATGM 311
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 72-152 2.07e-03

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 40.64  E-value: 2.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886  72 DTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAANCLYAylhipASHNKYYMLVARGLLGIGAGNVAV 151
Cdd:cd17315    32 STSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSA-----LAPNVWVLIVGRFLLGLGVGLASV 106


                  .
gi 1706865886 152 V 152
Cdd:cd17315   107 L 107
MFS_1 pfam07690
Major Facilitator Superfamily;
408-501 2.22e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 40.48  E-value: 2.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 408 AWCLYTPVIHLAQFLTSAVLIGLGYPVCNLMSYTLYSKILGPKPQGVYMGWLTASGSGARILGPMFISQVYAHWGPRWAF 487
Cdd:pfam07690  75 GLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAF 154

                          90
                  ....*....|....
gi 1706865886 488 SLVCGIIVLTITLL 501
Cdd:pfam07690 155 LILAILSLLAAVLL 168
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 37-183 2.41e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 40.23  E-value: 2.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886  37 RSIRILYLTMFLSSVGFSVVMMSIWPYLQKIDPtADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVA 116
Cdd:cd17321   168 RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLG-YSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAV 246

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 117 ANCLYAYLHIPAShnKYYMLVARGLLGIGAGNVAVVRSYTAGATSLQERT---SSMANisMCQALGFILG 183
Cdd:cd17321   247 GLLLLALLGADSS--VWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAgaaSGILN--TARQLGGALG 312
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 42-362 2.99e-03

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 39.86  E-value: 2.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886  42 LYLTMFLSSVGFSVVMM--SIWPYLQKiDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAANC 119
Cdd:cd17474     1 LYAVFFATLLAVLGVSIvdPILPAIAE-ALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 120 LYAylhipASHNKYYMLVARGLLGIGAG-----NVAVVRSYTAGAtslqERTSSMANISMCQALGFILGPgrffqtcftF 194
Cdd:cd17474    80 LCG-----LSDSFALLLAGRALQGIGAAglgplALTLIGDLFEGG----ERAKAMGLYEAALGLGIAVGP---------L 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 195 LGEKGVTWDviklqinmYTTPVLLSAFLGILNIILILAILRE-HRVDDSGRQCKSINFEEASTDEaqvpqgnidqvavvA 273
Cdd:cd17474   142 LGGLLAAIS--------WRYPFFLLAALIPVAFLAILFLLPEpKEKAKSSSATKLRDLKKALRGR--------------G 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 274 INVLFFVTLFIFALFETIIT--PLTMDMyawTQEQAVLYNGIILAALGVE-AVVIFLGVKLLSKKIGERAILLGGLIVVW 350
Cdd:cd17474   200 LLTFLVSAFLYFFLYFAFLTylPFLLEL---LYGISPIIIGLLFAGWSVLlALGSLFVGRLLKKRFGARRILVIGLLLYA 276

                         330
                  ....*....|..
gi 1706865886 351 VGFFILLPWGNQ 362
Cdd:cd17474   277 LSLLLLGFVPSL 288
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 73-184 3.50e-03

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 39.89  E-value: 3.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886  73 TSFL-GWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAANCLYAYlhipaSHNKYYMLVARGLLGIGAGNvAV 151
Cdd:cd17472    30 TPTLiGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAY-----ATSIYGLILGRALQGSGAIS-SV 103

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1706865886 152 VRSYTAGATSLQERTSSMA----NISMCQALGFILGP 184
Cdd:cd17472   104 VMALLADLTREENRTKAMAligaSIGIAFAISMVLGP 140
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
276-507 3.53e-03

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 39.86  E-value: 3.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 276 VLFFVTLFIFALFETIITPLTMDMYAWTQEQAVLYNGI--ILAALGVeavvIFLGVklLSKKIGERAILLGGLIVVWVGF 353
Cdd:COG2223   212 LLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALfaLLGALGR----PLGGW--LSDRIGGRRVLLIVFALMALGL 285

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886 354 FILLPWGNQFPkiqwedlhnnsipnttfgeiiiglwkspmeddnerptgcsieqawclytpvihlaQFLTSAVLIGLGYP 433
Cdd:COG2223   286 LLLALALGSLW-------------------------------------------------------LFLVLFLLLGLALG 310

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1706865886 434 VCNLMSYTLYSKILGPKPQGVYMGWLTASGSGARILGPMFISQVYAHWG-PRWAFSLVCGIIVLTITLLGVVYKR 507
Cdd:COG2223   311 GGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTLLLYRR 385
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 35-152 4.67e-03

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 39.51  E-value: 4.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886  35 RWRSIRILYLTMFLSSVGFSVVMMSIWPYLQKIDPTADTSFlgWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILIS 114
Cdd:cd17332   219 KNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELV--LLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLA 296

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1706865886 115 VAANCLYAYLHipaSHNKYYMLVARGLLGIGAGNVAVV 152
Cdd:cd17332   297 ILGLLLLFFLP---PGNLVLILVLAVLAGIGYGGANLL 331
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 44-184 8.18e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 38.69  E-value: 8.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706865886  44 LTMFLSSVGFSVVMMSIwPYLQKiDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAANCLYAY 123
Cdd:cd17321     3 LAVFLAALDVTIVNVAL-PTIAR-DLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1706865886 124 lhipaSHNKYYMLVARGLLGIGAG-----NVAVVRSYTAGAtslqERTSSMANISMCQALGFILGP 184
Cdd:cd17321    81 -----APSLAFLIAARALQGIGAAaimpaSLALIAATFPGE----RRGRALGLWGAVVGIGAALGP 137
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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