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Conserved domains on  [gi|1678781278|ref|NP_001357769|]
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cilia- and flagella-associated protein 251 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 756-1070 1.11e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 76.22  E-value: 1.11e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278  756 RDAVYAVSCHPYQPLIAVGSVCGMIKVWDFEKKVYLFSRTfEKGLGVQCLTYNPEGALLGAGFTEGTVYILDAMSleNES 835
Cdd:cd00200      9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLK-GHTGPVRDVAASADGTYLASGSSDKTIRLWDLET--GEC 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278  836 PEPFKYSKSSVSHCCFSHDSNYMATADVNFTVavymvvvkngqRVWE-----YLARLRSHQNSIQSLLFgvhlDSNEPRL 910
Cdd:cd00200     86 VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTI-----------KVWDvetgkCLTTLRGHTDWVNSVAF----SPDGTFV 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278  911 LSLGKDRFLIEYNLvKSCKdHLDVLDVHrTDQGNyptCMIWYPPLTKelfLLICNSGYKVKLFNATTKMCRKTLLGPayG 990
Cdd:cd00200    151 ASSSQDGTIKLWDL-RTGK-CVATLTGH-TGEVN---SVAFSPDGEK---LLSSSSDGTIKLWDLSTGKCLGTLRGH--E 219

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278  991 SPIEHAQVLPvkstlelQKRYLVFINKDKVgLQILPVD-GNPHKTcaIVCHPNGVAGMALSYDGRFAFTaGGQDRSVVQW 1069
Cdd:cd00200    220 NGVNSVAFSP-------DGYLLASGSEDGT-IRVWDLRtGECVQT--LSGHTNSVTSLAWSPDGKRLAS-GSADGTIRIW 288


                   .
gi 1678781278 1070 K 1070
Cdd:cd00200    289 D 289
WD40 COG2319
WD40 repeat [General function prediction only];
341-786 3.77e-13

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 73.02  E-value: 3.77e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278  341 ASQKPEDILAQGKDEARLSLEERRKLFQSKGLSAEESLVSVSTEDTLFQKEEDSKVYPLSMTWSFGWNSSLPVYYMREDR 420
Cdd:COG2319     12 ASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGR 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278  421 RVILYTCAHTAIMYDVVRNTQYH-LQGHPNIISCLCVSEDRRWIATADEgpDCLIIIWDSFTGIPVHTIFDscpEGNGMR 499
Cdd:COG2319     92 LLASASADGTVRLWDLATGLLLRtLTGHTGAVRSVAFSPDGKTLASGSA--DGTVRLWDLATGKLLRTLTG---HSGAVT 166

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278  500 SIAITRDSKFLATISDSATqkVCIWKwtlaVETPACTLELPKEYGFQDNLVFNPaNNKELVSNSktqaiyycwfEDKGI- 578
Cdd:COG2319    167 SVAFSPDGKLLASGSDDGT--VRLWD----LATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGS----------ADGTVr 229

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278  579 ---LAHSAPVLTEKTFNKLVgkfsQSV-FHLKLPQVLSATKEGKLVVWDihypsstsssaisafpfIKPRKLVHLQKEAI 654
Cdd:COG2319    230 lwdLATGKLLRTLTGHSGSV----RSVaFSPDGRLLASGSADGTVRLWD-----------------LATGELLRTLTGHS 288

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278  655 TVLMTI-----DSYIVTGDIKGNIKFYD-HTLSVVNWYSNFKlGAIRTLSFSktipslpteksnlPTDCTLrgdlfvvrn 728
Cdd:COG2319    289 GGVNSVafspdGKLLASGSDDGTVRLWDlATGKLLRTLTGHT-GAVRSVAFS-------------PDGKTL--------- 345

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1678781278  729 fIIGTFDATVYHMTVDGTKLEKLFVEPRDAVYAVSCHPYQPLIAVGSVCGMIKVWDFE 786
Cdd:COG2319    346 -ASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
PTZ00183 super family cl33171
centrin; Provisional
 1136-1239 1.54e-05

centrin; Provisional


The actual alignment was detected with superfamily member PTZ00183:

Pssm-ID: 185503 [Multi-domain]  Cd Length: 158  Bit Score: 46.61  E-value: 1.54e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278 1136 ELPFVMRAIGFYPSEEKIEDMFNEIKFSEYvetgkliDKINLPDFLK---VYLNHRppfgNTMDGIQNSFNVLGyTNSEG 1212
Cdd:PTZ00183    38 ELKVAMRSLGFEPKKEEIKQMIADVDKDGS-------GKIDFEEFLDimtKKLGER----DPREEILKAFRLFD-DDKTG 105

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1678781278 1213 K---KAIRRedflnllLTK--GEHMTEEE---MID 1239
Cdd:PTZ00183   106 KislKNLKR-------VAKelGETITDEElqeMID 133
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 756-1070 1.11e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.22  E-value: 1.11e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278  756 RDAVYAVSCHPYQPLIAVGSVCGMIKVWDFEKKVYLFSRTfEKGLGVQCLTYNPEGALLGAGFTEGTVYILDAMSleNES 835
Cdd:cd00200      9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLK-GHTGPVRDVAASADGTYLASGSSDKTIRLWDLET--GEC 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278  836 PEPFKYSKSSVSHCCFSHDSNYMATADVNFTVavymvvvkngqRVWE-----YLARLRSHQNSIQSLLFgvhlDSNEPRL 910
Cdd:cd00200     86 VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTI-----------KVWDvetgkCLTTLRGHTDWVNSVAF----SPDGTFV 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278  911 LSLGKDRFLIEYNLvKSCKdHLDVLDVHrTDQGNyptCMIWYPPLTKelfLLICNSGYKVKLFNATTKMCRKTLLGPayG 990
Cdd:cd00200    151 ASSSQDGTIKLWDL-RTGK-CVATLTGH-TGEVN---SVAFSPDGEK---LLSSSSDGTIKLWDLSTGKCLGTLRGH--E 219

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278  991 SPIEHAQVLPvkstlelQKRYLVFINKDKVgLQILPVD-GNPHKTcaIVCHPNGVAGMALSYDGRFAFTaGGQDRSVVQW 1069
Cdd:cd00200    220 NGVNSVAFSP-------DGYLLASGSEDGT-IRVWDLRtGECVQT--LSGHTNSVTSLAWSPDGKRLAS-GSADGTIRIW 288


                   .
gi 1678781278 1070 K 1070
Cdd:cd00200    289 D 289
WD40 COG2319
WD40 repeat [General function prediction only];
341-786 3.77e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 73.02  E-value: 3.77e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278  341 ASQKPEDILAQGKDEARLSLEERRKLFQSKGLSAEESLVSVSTEDTLFQKEEDSKVYPLSMTWSFGWNSSLPVYYMREDR 420
Cdd:COG2319     12 ASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGR 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278  421 RVILYTCAHTAIMYDVVRNTQYH-LQGHPNIISCLCVSEDRRWIATADEgpDCLIIIWDSFTGIPVHTIFDscpEGNGMR 499
Cdd:COG2319     92 LLASASADGTVRLWDLATGLLLRtLTGHTGAVRSVAFSPDGKTLASGSA--DGTVRLWDLATGKLLRTLTG---HSGAVT 166

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278  500 SIAITRDSKFLATISDSATqkVCIWKwtlaVETPACTLELPKEYGFQDNLVFNPaNNKELVSNSktqaiyycwfEDKGI- 578
Cdd:COG2319    167 SVAFSPDGKLLASGSDDGT--VRLWD----LATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGS----------ADGTVr 229

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278  579 ---LAHSAPVLTEKTFNKLVgkfsQSV-FHLKLPQVLSATKEGKLVVWDihypsstsssaisafpfIKPRKLVHLQKEAI 654
Cdd:COG2319    230 lwdLATGKLLRTLTGHSGSV----RSVaFSPDGRLLASGSADGTVRLWD-----------------LATGELLRTLTGHS 288

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278  655 TVLMTI-----DSYIVTGDIKGNIKFYD-HTLSVVNWYSNFKlGAIRTLSFSktipslpteksnlPTDCTLrgdlfvvrn 728
Cdd:COG2319    289 GGVNSVafspdGKLLASGSDDGTVRLWDlATGKLLRTLTGHT-GAVRSVAFS-------------PDGKTL--------- 345

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1678781278  729 fIIGTFDATVYHMTVDGTKLEKLFVEPRDAVYAVSCHPYQPLIAVGSVCGMIKVWDFE 786
Cdd:COG2319    346 -ASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
730-1072 6.98e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.17  E-value: 6.98e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278  730 IIGTFDATVYHMTVDGTKLEKLFVEPRDAVYAVSCHPYQPLIAVGSVCGMIKVWDFEKKVYLfsRTFE-KGLGVQCLTYN 808
Cdd:COG2319     94 ASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLL--RTLTgHSGAVTSVAFS 171

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278  809 PEGALLGAGFTEGTVYILDAmsLENESPEPFKYSKSSVSHCCFSHDSNYMATADVNFTVavymvvvkngqRVW-----EY 883
Cdd:COG2319    172 PDGKLLASGSDDGTVRLWDL--ATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTV-----------RLWdlatgKL 238

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278  884 LARLRSHQNSIQSLLFgvhlDSNEPRLLSLGKDRFLIEYNL-----VKSCKDHLD-VLDVHRTDQGNYptcmiwyppltk 957
Cdd:COG2319    239 LRTLTGHSGSVRSVAF----SPDGRLLASGSADGTVRLWDLatgelLRTLTGHSGgVNSVAFSPDGKL------------ 302

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278  958 elfLLICNSGYKVKLFNATTKMCRKTLLGPayGSPIEHAQVLPvkstlelQKRYLVFINKDKV--------GLQILPVDG 1029
Cdd:COG2319    303 ---LASGSDDGTVRLWDLATGKLLRTLTGH--TGAVRSVAFSP-------DGKTLASGSDDGTvrlwdlatGELLRTLTG 370

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|...
gi 1678781278 1030 nphktcaivcHPNGVAGMALSYDGRFAFTAGGqDRSVVQWKIN 1072
Cdd:COG2319    371 ----------HTGAVTSVAFSPDGRTLASGSA-DGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 443-825 2.91e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 65.82  E-value: 2.91e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278  443 HLQGHPNIISCLCVSEDRRWIATADEgpDCLIIIWDSFTGIPVHTIfdsCPEGNGMRSIAITRDSKFLATISDSATqkVC 522
Cdd:cd00200      4 TLKGHTGGVTCVAFSPDGKLLATGSG--DGTIKVWDLETGELLRTL---KGHTGPVRDVAASADGTYLASGSSDKT--IR 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278  523 IWKWtlavETPACTLELpkeygfqdnlvfnpannkelvsnsktqaiyycwfedkgiLAHSAPVLTektfnklvGKFSQSv 602
Cdd:cd00200     77 LWDL----ETGECVRTL---------------------------------------TGHTSYVSS--------VAFSPD- 104

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278  603 fhlklPQVLSATKE-GKLVVWDIhypsstsssaisafPFIKPRKLVHLQKEAIT-VLMTIDS-YIVTGDIKGNIKFYD-H 678
Cdd:cd00200    105 -----GRILSSSSRdKTIKVWDV--------------ETGKCLTTLRGHTDWVNsVAFSPDGtFVASSSQDGTIKLWDlR 165

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278  679 TLSVVNWYSNFKlGAIRTLSFSktipslPTEKSnlptdctlrgdlfvvrnFIIGTFDATVYHMTVDGTKLEKLFVEPRDA 758
Cdd:cd00200    166 TGKCVATLTGHT-GEVNSVAFS------PDGEK-----------------LLSSSSDGTIKLWDLSTGKCLGTLRGHENG 221

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1678781278  759 VYAVSCHPYQPLIAVGSVCGMIKVWDFEKKVYLfsRTFEKGLG-VQCLTYNPEGALLGAGFTEGTVYI 825
Cdd:cd00200    222 VNSVAFSPDGYLLASGSEDGTIRVWDLRTGECV--QTLSGHTNsVTSLAWSPDGKRLASGSADGTIRI 287
PTZ00183 PTZ00183
centrin; Provisional
 1136-1239 1.54e-05

centrin; Provisional


Pssm-ID: 185503 [Multi-domain]  Cd Length: 158  Bit Score: 46.61  E-value: 1.54e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278 1136 ELPFVMRAIGFYPSEEKIEDMFNEIKFSEYvetgkliDKINLPDFLK---VYLNHRppfgNTMDGIQNSFNVLGyTNSEG 1212
Cdd:PTZ00183    38 ELKVAMRSLGFEPKKEEIKQMIADVDKDGS-------GKIDFEEFLDimtKKLGER----DPREEILKAFRLFD-DDKTG 105

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1678781278 1213 K---KAIRRedflnllLTK--GEHMTEEE---MID 1239
Cdd:PTZ00183   106 KislKNLKR-------VAKelGETITDEElqeMID 133
WD40 pfam00400
WD domain, G-beta repeat;
438-478 2.90e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 2.90e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1678781278  438 RNTQYHLQGHPNIISCLCVSEDRRWIATADEgpDCLIIIWD 478
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSD--DGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 444-478 3.41e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 3.41e-04
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 1678781278   444 LQGHPNIISCLCVSEDRRWIATADEgpDCLIIIWD 478
Cdd:smart00320    8 LKGHTGPVTSVAFSPDGKYLASGSD--DGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
747-784 9.65e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 9.65e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1678781278  747 KLEKLFVEPRDAVYAVSCHPYQPLIAVGSVCGMIKVWD 784
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 756-1070 1.11e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.22  E-value: 1.11e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278  756 RDAVYAVSCHPYQPLIAVGSVCGMIKVWDFEKKVYLFSRTfEKGLGVQCLTYNPEGALLGAGFTEGTVYILDAMSleNES 835
Cdd:cd00200      9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLK-GHTGPVRDVAASADGTYLASGSSDKTIRLWDLET--GEC 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278  836 PEPFKYSKSSVSHCCFSHDSNYMATADVNFTVavymvvvkngqRVWE-----YLARLRSHQNSIQSLLFgvhlDSNEPRL 910
Cdd:cd00200     86 VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTI-----------KVWDvetgkCLTTLRGHTDWVNSVAF----SPDGTFV 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278  911 LSLGKDRFLIEYNLvKSCKdHLDVLDVHrTDQGNyptCMIWYPPLTKelfLLICNSGYKVKLFNATTKMCRKTLLGPayG 990
Cdd:cd00200    151 ASSSQDGTIKLWDL-RTGK-CVATLTGH-TGEVN---SVAFSPDGEK---LLSSSSDGTIKLWDLSTGKCLGTLRGH--E 219

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278  991 SPIEHAQVLPvkstlelQKRYLVFINKDKVgLQILPVD-GNPHKTcaIVCHPNGVAGMALSYDGRFAFTaGGQDRSVVQW 1069
Cdd:cd00200    220 NGVNSVAFSP-------DGYLLASGSEDGT-IRVWDLRtGECVQT--LSGHTNSVTSLAWSPDGKRLAS-GSADGTIRIW 288


                   .
gi 1678781278 1070 K 1070
Cdd:cd00200    289 D 289
WD40 COG2319
WD40 repeat [General function prediction only];
341-786 3.77e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 73.02  E-value: 3.77e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278  341 ASQKPEDILAQGKDEARLSLEERRKLFQSKGLSAEESLVSVSTEDTLFQKEEDSKVYPLSMTWSFGWNSSLPVYYMREDR 420
Cdd:COG2319     12 ASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGR 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278  421 RVILYTCAHTAIMYDVVRNTQYH-LQGHPNIISCLCVSEDRRWIATADEgpDCLIIIWDSFTGIPVHTIFDscpEGNGMR 499
Cdd:COG2319     92 LLASASADGTVRLWDLATGLLLRtLTGHTGAVRSVAFSPDGKTLASGSA--DGTVRLWDLATGKLLRTLTG---HSGAVT 166

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278  500 SIAITRDSKFLATISDSATqkVCIWKwtlaVETPACTLELPKEYGFQDNLVFNPaNNKELVSNSktqaiyycwfEDKGI- 578
Cdd:COG2319    167 SVAFSPDGKLLASGSDDGT--VRLWD----LATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGS----------ADGTVr 229

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278  579 ---LAHSAPVLTEKTFNKLVgkfsQSV-FHLKLPQVLSATKEGKLVVWDihypsstsssaisafpfIKPRKLVHLQKEAI 654
Cdd:COG2319    230 lwdLATGKLLRTLTGHSGSV----RSVaFSPDGRLLASGSADGTVRLWD-----------------LATGELLRTLTGHS 288

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278  655 TVLMTI-----DSYIVTGDIKGNIKFYD-HTLSVVNWYSNFKlGAIRTLSFSktipslpteksnlPTDCTLrgdlfvvrn 728
Cdd:COG2319    289 GGVNSVafspdGKLLASGSDDGTVRLWDlATGKLLRTLTGHT-GAVRSVAFS-------------PDGKTL--------- 345

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1678781278  729 fIIGTFDATVYHMTVDGTKLEKLFVEPRDAVYAVSCHPYQPLIAVGSVCGMIKVWDFE 786
Cdd:COG2319    346 -ASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 662-916 1.54e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 69.67  E-value: 1.54e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278  662 SYIVTGDIKGNIKFYD------------HTLSV--VNWYSNFKLgaIRTLSFSKTIPSLPTEKSNLPTdcTLRGDLFVVR 727
Cdd:cd00200     22 KLLATGSGDGTIKVWDletgellrtlkgHTGPVrdVAASADGTY--LASGSSDKTIRLWDLETGECVR--TLTGHTSYVS 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278  728 -------NFII--GTFDATVYHMTVDGTKLEKLFVEPRDAVYAVSCHPYQPLIAVGSVCGMIKVWDFE--KKVYLFsrTF 796
Cdd:cd00200     98 svafspdGRILssSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRtgKCVATL--TG 175

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278  797 EKGlGVQCLTYNPEGALLGAGFTEGTVYILDAMSLenESPEPFKYSKSSVSHCCFSHDSNYMATADVNFTVAVYMVvvkn 876
Cdd:cd00200    176 HTG-EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG--KCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDL---- 248

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|
gi 1678781278  877 gqRVWEYLARLRSHQNSIQSLLFgvhlDSNEPRLLSLGKD 916
Cdd:cd00200    249 --RTGECVQTLSGHTNSVTSLAW----SPDGKRLASGSAD 282
WD40 COG2319
WD40 repeat [General function prediction only];
730-1072 6.98e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.17  E-value: 6.98e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278  730 IIGTFDATVYHMTVDGTKLEKLFVEPRDAVYAVSCHPYQPLIAVGSVCGMIKVWDFEKKVYLfsRTFE-KGLGVQCLTYN 808
Cdd:COG2319     94 ASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLL--RTLTgHSGAVTSVAFS 171

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278  809 PEGALLGAGFTEGTVYILDAmsLENESPEPFKYSKSSVSHCCFSHDSNYMATADVNFTVavymvvvkngqRVW-----EY 883
Cdd:COG2319    172 PDGKLLASGSDDGTVRLWDL--ATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTV-----------RLWdlatgKL 238

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278  884 LARLRSHQNSIQSLLFgvhlDSNEPRLLSLGKDRFLIEYNL-----VKSCKDHLD-VLDVHRTDQGNYptcmiwyppltk 957
Cdd:COG2319    239 LRTLTGHSGSVRSVAF----SPDGRLLASGSADGTVRLWDLatgelLRTLTGHSGgVNSVAFSPDGKL------------ 302

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278  958 elfLLICNSGYKVKLFNATTKMCRKTLLGPayGSPIEHAQVLPvkstlelQKRYLVFINKDKV--------GLQILPVDG 1029
Cdd:COG2319    303 ---LASGSDDGTVRLWDLATGKLLRTLTGH--TGAVRSVAFSP-------DGKTLASGSDDGTvrlwdlatGELLRTLTG 370

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|...
gi 1678781278 1030 nphktcaivcHPNGVAGMALSYDGRFAFTAGGqDRSVVQWKIN 1072
Cdd:COG2319    371 ----------HTGAVTSVAFSPDGRTLASGSA-DGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 443-825 2.91e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 65.82  E-value: 2.91e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278  443 HLQGHPNIISCLCVSEDRRWIATADEgpDCLIIIWDSFTGIPVHTIfdsCPEGNGMRSIAITRDSKFLATISDSATqkVC 522
Cdd:cd00200      4 TLKGHTGGVTCVAFSPDGKLLATGSG--DGTIKVWDLETGELLRTL---KGHTGPVRDVAASADGTYLASGSSDKT--IR 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278  523 IWKWtlavETPACTLELpkeygfqdnlvfnpannkelvsnsktqaiyycwfedkgiLAHSAPVLTektfnklvGKFSQSv 602
Cdd:cd00200     77 LWDL----ETGECVRTL---------------------------------------TGHTSYVSS--------VAFSPD- 104

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278  603 fhlklPQVLSATKE-GKLVVWDIhypsstsssaisafPFIKPRKLVHLQKEAIT-VLMTIDS-YIVTGDIKGNIKFYD-H 678
Cdd:cd00200    105 -----GRILSSSSRdKTIKVWDV--------------ETGKCLTTLRGHTDWVNsVAFSPDGtFVASSSQDGTIKLWDlR 165

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278  679 TLSVVNWYSNFKlGAIRTLSFSktipslPTEKSnlptdctlrgdlfvvrnFIIGTFDATVYHMTVDGTKLEKLFVEPRDA 758
Cdd:cd00200    166 TGKCVATLTGHT-GEVNSVAFS------PDGEK-----------------LLSSSSDGTIKLWDLSTGKCLGTLRGHENG 221

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1678781278  759 VYAVSCHPYQPLIAVGSVCGMIKVWDFEKKVYLfsRTFEKGLG-VQCLTYNPEGALLGAGFTEGTVYI 825
Cdd:cd00200    222 VNSVAFSPDGYLLASGSEDGTIRVWDLRTGECV--QTLSGHTNsVTSLAWSPDGKRLASGSADGTIRI 287
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 424-525 3.13e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 53.49  E-value: 3.13e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278  424 LYTCAH--TAIMYDVVRNTQYH-LQGHPNIISCLCVSEDRRWIATADEgpDCLIIIWDSFTGIPVHTIfdSCPEgNGMRS 500
Cdd:cd00200    192 LLSSSSdgTIKLWDLSTGKCLGtLRGHENGVNSVAFSPDGYLLASGSE--DGTIRVWDLRTGECVQTL--SGHT-NSVTS 266

                           90       100
                   ....*....|....*....|....*
gi 1678781278  501 IAITRDSKFLATISDSATQKvcIWK 525
Cdd:cd00200    267 LAWSPDGKRLASGSADGTIR--IWD 289
PTZ00183 PTZ00183
centrin; Provisional
 1136-1239 1.54e-05

centrin; Provisional


Pssm-ID: 185503 [Multi-domain]  Cd Length: 158  Bit Score: 46.61  E-value: 1.54e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278 1136 ELPFVMRAIGFYPSEEKIEDMFNEIKFSEYvetgkliDKINLPDFLK---VYLNHRppfgNTMDGIQNSFNVLGyTNSEG 1212
Cdd:PTZ00183    38 ELKVAMRSLGFEPKKEEIKQMIADVDKDGS-------GKIDFEEFLDimtKKLGER----DPREEILKAFRLFD-DDKTG 105

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1678781278 1213 K---KAIRRedflnllLTK--GEHMTEEE---MID 1239
Cdd:PTZ00183   106 KislKNLKR-------VAKelGETITDEElqeMID 133
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 430-585 1.65e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 48.10  E-value: 1.65e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278  430 TAIMYDVVRNTQ-YHLQGHPNIISCLCVSEDRRWIATADEgpDCLIIIWDSFTGIPVHTIfdscpEG--NGMRSIAITRD 506
Cdd:cd00200    116 TIKVWDVETGKClTTLRGHTDWVNSVAFSPDGTFVASSSQ--DGTIKLWDLRTGKCVATL-----TGhtGEVNSVAFSPD 188

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278  507 -SKFLATISDSatqkvCIWKWTLAVETPACTLELPKEYGFqdNLVFNPaNNKELVSNSKTQAIyYCWFEDKG-----ILA 580
Cdd:cd00200    189 gEKLLSSSSDG-----TIKLWDLSTGKCLGTLRGHENGVN--SVAFSP-DGYLLASGSEDGTI-RVWDLRTGecvqtLSG 259


                   ....*
gi 1678781278  581 HSAPV 585
Cdd:cd00200    260 HTNSV 264
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 429-540 1.11e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.79  E-value: 1.11e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278  429 HTAIMYDVVRNTQYH-LQGHPNIISCLCVSEDRRWIATAdeGPDCLIIIWDSFTGIPVHTIFDScpeGNGMRSIAITRDS 507
Cdd:cd00200    157 GTIKLWDLRTGKCVAtLTGHTGEVNSVAFSPDGEKLLSS--SSDGTIKLWDLSTGKCLGTLRGH---ENGVNSVAFSPDG 231

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1678781278  508 KFLAtiSDSATQKVCIWKWtlavETPACTLELP 540
Cdd:cd00200    232 YLLA--SGSEDGTIRVWDL----RTGECVQTLS 258
WD40 pfam00400
WD domain, G-beta repeat;
438-478 2.90e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 2.90e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1678781278  438 RNTQYHLQGHPNIISCLCVSEDRRWIATADEgpDCLIIIWD 478
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSD--DGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 444-478 3.41e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 3.41e-04
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 1678781278   444 LQGHPNIISCLCVSEDRRWIATADEgpDCLIIIWD 478
Cdd:smart00320    8 LKGHTGPVTSVAFSPDGKYLASGSD--DGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 424-624 5.36e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.48  E-value: 5.36e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278  424 LYTCA--HTAIMYDVVRNTQYH-LQGHPNIISCLCVSEDRRWIATAdeGPDCLIIIWDSFTGIPVHTIfdscpEG--NGM 498
Cdd:cd00200     66 LASGSsdKTIRLWDLETGECVRtLTGHTSYVSSVAFSPDGRILSSS--SRDKTIKVWDVETGKCLTTL-----RGhtDWV 138

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278  499 RSIAITRDSKFLATISDSATQKVciwkWTLAVETPACTLElpkeyGFQDN---LVFNPaNNKELVSNSKTQAI----YYC 571
Cdd:cd00200    139 NSVAFSPDGTFVASSSQDGTIKL----WDLRTGKCVATLT-----GHTGEvnsVAFSP-DGEKLLSSSSDGTIklwdLST 208

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1678781278  572 WFEDKGILAHSAPVLTektfnklvGKFSQsvfHLKLpqVLSATKEGKLVVWDI 624
Cdd:cd00200    209 GKCLGTLRGHENGVNS--------VAFSP---DGYL--LASGSEDGTIRVWDL 248
PTZ00184 PTZ00184
calmodulin; Provisional
 1132-1239 3.62e-03

calmodulin; Provisional


Pssm-ID: 185504 [Multi-domain]  Cd Length: 149  Bit Score: 39.36  E-value: 3.62e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678781278 1132 ICLSELPFVMRAIGFYPSEEKIEDMFNEIKFSeyvETGklidKINLPDFLKVYLNhRPPFGNTMDGIQNSFNVLgytNSE 1211
Cdd:PTZ00184    28 ITTKELGTVMRSLGQNPTEAELQDMINEVDAD---GNG----TIDFPEFLTLMAR-KMKDTDSEEEIKEAFKVF---DRD 96

                           90       100
                   ....*....|....*....|....*...
gi 1678781278 1212 GKKAIRREDFLNLLLTKGEHMTEEEMID 1239
Cdd:PTZ00184    97 GNGFISAAELRHVMTNLGEKLTDEEVDE 124
WD40 pfam00400
WD domain, G-beta repeat;
747-784 9.65e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 9.65e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1678781278  747 KLEKLFVEPRDAVYAVSCHPYQPLIAVGSVCGMIKVWD 784
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
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