NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1634229799|ref|NP_001357281|]
View 

DNA-directed RNA polymerase III subunit RPC7 isoform 2 [Homo sapiens]

Protein Classification

RPC7 family DNA-directed RNA polymerase III subunit( domain architecture ID 10569492)

RPC7 family DNA-directed RNA polymerase III subunit is a peripheral component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
RNA_pol_3_Rpc31 pfam11705
DNA-directed RNA polymerase III subunit Rpc31; RNA polymerase III contains seventeen subunits ...
33-208 3.92e-16

DNA-directed RNA polymerase III subunit Rpc31; RNA polymerase III contains seventeen subunits in yeasts and in human cells. Twelve of these are akin to RNA polymerase I or II and the other five are RNA pol III-specific, and form the functionally distinct groups (i) Rpc31-Rpc34-Rpc82, and (ii) Rpc37-Rpc53. Rpc31, Rpc34 and Rpc82 form a cluster of enzyme-specific subunits that contribute to transcription initiation in S.cerevisiae and H.sapiens. There is evidence that these subunits are anchored at or near the N-terminal Zn-fold of Rpc1, itself prolonged by a highly conserved but RNA polymerase III-specific domain.


:

Pssm-ID: 463324  Cd Length: 213  Bit Score: 73.94  E-value: 3.92e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634229799  33 KPPPLFPDTdYKPVPLKTGEGEEYMLALKQELRETMKRMPYFIETPEERQ----------------DIERYSKRYMKVYK 96
Cdd:pfam11705  14 APSPLFPPY-PLPVALPLTERERYQVALYLLFREQMHDGPFYTGSRTSKStgpkgvktkatfdpfdGIERYSDKYLKKER 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634229799  97 EEWIPDWRRLPREMMPR--------NKCKKGPKPKKAKDAGKGTPLTNTEDVLKKMEELEKRGDGEKSDEENEEKEGSKE 168
Cdd:pfam11705  93 ILPSLDERPFVKEFFPKelwptldgDDVGIAKKKKKKLGLSKVKSLRNAEDEGEEEEEEEAKGLSLLEKLKDLAEDEDDE 172
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1634229799 169 KSKEGDDDDDDDAAEQEEYDEEEQEEEND-YINSYFEDGDD 208
Cdd:pfam11705 173 DEKEEEDEEGEEEIEDEDFEDDDEDDGGDyNAEKYFDNGDD 213
 
Name Accession Description Interval E-value
RNA_pol_3_Rpc31 pfam11705
DNA-directed RNA polymerase III subunit Rpc31; RNA polymerase III contains seventeen subunits ...
33-208 3.92e-16

DNA-directed RNA polymerase III subunit Rpc31; RNA polymerase III contains seventeen subunits in yeasts and in human cells. Twelve of these are akin to RNA polymerase I or II and the other five are RNA pol III-specific, and form the functionally distinct groups (i) Rpc31-Rpc34-Rpc82, and (ii) Rpc37-Rpc53. Rpc31, Rpc34 and Rpc82 form a cluster of enzyme-specific subunits that contribute to transcription initiation in S.cerevisiae and H.sapiens. There is evidence that these subunits are anchored at or near the N-terminal Zn-fold of Rpc1, itself prolonged by a highly conserved but RNA polymerase III-specific domain.


Pssm-ID: 463324  Cd Length: 213  Bit Score: 73.94  E-value: 3.92e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634229799  33 KPPPLFPDTdYKPVPLKTGEGEEYMLALKQELRETMKRMPYFIETPEERQ----------------DIERYSKRYMKVYK 96
Cdd:pfam11705  14 APSPLFPPY-PLPVALPLTERERYQVALYLLFREQMHDGPFYTGSRTSKStgpkgvktkatfdpfdGIERYSDKYLKKER 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634229799  97 EEWIPDWRRLPREMMPR--------NKCKKGPKPKKAKDAGKGTPLTNTEDVLKKMEELEKRGDGEKSDEENEEKEGSKE 168
Cdd:pfam11705  93 ILPSLDERPFVKEFFPKelwptldgDDVGIAKKKKKKLGLSKVKSLRNAEDEGEEEEEEEAKGLSLLEKLKDLAEDEDDE 172
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1634229799 169 KSKEGDDDDDDDAAEQEEYDEEEQEEEND-YINSYFEDGDD 208
Cdd:pfam11705 173 DEKEEEDEEGEEEIEDEDFEDDDEDDGGDyNAEKYFDNGDD 213
 
Name Accession Description Interval E-value
RNA_pol_3_Rpc31 pfam11705
DNA-directed RNA polymerase III subunit Rpc31; RNA polymerase III contains seventeen subunits ...
33-208 3.92e-16

DNA-directed RNA polymerase III subunit Rpc31; RNA polymerase III contains seventeen subunits in yeasts and in human cells. Twelve of these are akin to RNA polymerase I or II and the other five are RNA pol III-specific, and form the functionally distinct groups (i) Rpc31-Rpc34-Rpc82, and (ii) Rpc37-Rpc53. Rpc31, Rpc34 and Rpc82 form a cluster of enzyme-specific subunits that contribute to transcription initiation in S.cerevisiae and H.sapiens. There is evidence that these subunits are anchored at or near the N-terminal Zn-fold of Rpc1, itself prolonged by a highly conserved but RNA polymerase III-specific domain.


Pssm-ID: 463324  Cd Length: 213  Bit Score: 73.94  E-value: 3.92e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634229799  33 KPPPLFPDTdYKPVPLKTGEGEEYMLALKQELRETMKRMPYFIETPEERQ----------------DIERYSKRYMKVYK 96
Cdd:pfam11705  14 APSPLFPPY-PLPVALPLTERERYQVALYLLFREQMHDGPFYTGSRTSKStgpkgvktkatfdpfdGIERYSDKYLKKER 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634229799  97 EEWIPDWRRLPREMMPR--------NKCKKGPKPKKAKDAGKGTPLTNTEDVLKKMEELEKRGDGEKSDEENEEKEGSKE 168
Cdd:pfam11705  93 ILPSLDERPFVKEFFPKelwptldgDDVGIAKKKKKKLGLSKVKSLRNAEDEGEEEEEEEAKGLSLLEKLKDLAEDEDDE 172
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1634229799 169 KSKEGDDDDDDDAAEQEEYDEEEQEEEND-YINSYFEDGDD 208
Cdd:pfam11705 173 DEKEEEDEEGEEEIEDEDFEDDDEDDGGDyNAEKYFDNGDD 213
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH